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• Dual-targeting CD73/PD-L1 bifunctional inhibitor: a promising cancer immunotherapy strategy.
  This work aims to design and characterize a novel bifunctional small molecule that simultaneously targets PD-L1 and CD73 to enhance the therapeutic efficacy of tumor immunotherapy.
  pubmed Du JJ, Wu S, Cheng S, Zeng X 等 2026 置信度 0.82
• TNF-α blockade with adalimumab restores bone metabolism in rheumatoid arthritis by regulating cytokines and inflammatory cell infiltration.
  To investigate the mechanisms underlying the bone-sparing effects of the anti-TNF antibody adalimumab in rheumatoid arthritis (RA) by examining synovial tissue and its direct effect on osteoblasts and osteoclasts.
  pubmed Krishnamurthy A, Revu S, Neregård P, Hensvold A 等 2026 置信度 0.82
• The role and function of CTLA-4 in Sjögren's syndrome.
  Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a key immune checkpoint involved in immune regulation. CTLA-4 inhibitors have been widely used in cancer therapy and have attracted increasing attention in autoimmune diseases such as Sjögren's syndr…
  pubmed Wen J, Zhang L, Xie L, Zhou D 等 2026 置信度 0.82
• Targeting the deubiquitinase USP28 in cancer: navigating context-dependent mechanisms and therapeutic resistance.
  Ubiquitin-specific protease 28 (USP28) is a deubiquitinating enzyme initially identified as a regulator that stabilizes p53 and c-MYC in response to DNA damage stress. Beyond its role in maintaining genomic integrity and cell cycle checkpoints, USP28 is implic…
  pubmed Luo T, Wu S, Wang Q, Yin J 等 2026 置信度 0.82
• AI agents are checking the scientific literature - and spotting decades-old errors.
  pubmed Stokel-Walker C 2026 Aug 置信度 0.82
• Structure-based scaffold hopping reveals strategies to overcome oncogenic KIT and PDGFRA mutation-driven drug-resistance in GIST.
  Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract. Current tyrosine kinase inhibitors (TKIs) targeting oncogenic KIT and PDGFRA have improved patient outcomes, yet off-target toxicities and drug resista…
  pubmed Schulz T, Beerbaum M, Scrima A, Jantzen H 等 2026 Aug 6 置信度 0.82
• Post-transplant hypomethylating agents plus venetoclax maintenance improves survival in high-risk myeloid malignancies: A matched cohort study.
  pubmed Thigpen H, Diebold K, Mudd T, Hardee M 等 2026 Aug 6 置信度 0.82
• 18β-Glycyrrhetinic acid ameliorates renal anemia via inactivating PHD2 and activating HIF-2α-EPO axis.
  18β-Glycyrrhetinic acid (GA) is a major metabolite of glycyrrhizin (GL) that is a key ingredient of licorice, a popular edible and medicinal plant, and is often used in the food and pharmaceutical industry as a flavoring agent. Previous studies suggest t…
  pubmed Li J, Han K, Fu Y, Zhao C 等 2026 Oct 1 置信度 0.82
• Evaluation of patient centred digital adherence technology for tuberculosis treatment outcomes: pragmatic randomised controlled trial.
  To evaluate the effectiveness of Tuberculosis Treatment Support Tools (TB-TST), a patient centred digital adherence technology, in improving treatment outcomes among individuals with drug susceptible tuberculosis in Argentina.
  pubmed Rubinstein F, Moraes Morelli D, Palma I, Sanjurjo M 等 2026 Aug 6 置信度 0.82
• A regulatory T cell-biased IL-2 mutein inhibits the development of allergen-specific Th2 cells and allergic asthma.
  Restoring durable allergen tolerance remains a challenge in the treatment of allergic asthma. Regulatory T cells (Tregs) represent attractive therapeutic targets since they can potently restrain allergen-specific type 2 effector T cell (Th2) responses. Agents …
  pubmed Selle A, Yero A, Moon JJ, Campbell DJ 等 2026 Aug 6 置信度 0.82
• Assessment and validation of the established free-running framework for cardiac function by magnetic resonance imaging at 1.5T (FAST-CMR): an international multi-center, multi-vendor study.
  Cardiovascular magnetic resonance (CMR) is the reference standard for assessing cardiac function, yet its widespread clinical use remains challenged by time-intensive workflows requiring ECG gating, repetitive breath-holding, and expert planning. The free-runn…
  pubmed Eyre K, Kaya K, Coudert T, Roy CW 等 2026 Aug 6 置信度 0.82
• 4-Methylcatechol attenuates NLRP3 inflammasome activation to limit inflammation.
  NACHT-, LRR- and pyrin domain-containing protein 3 (NLRP3) is an intracellular sensor that detects exogenous pathogenic invasions and endogenous cellular damage, leading to the NLRP3 inflammasome activation, which plays vital roles in host defense and contribu…
  pubmed Qin D, Fu Y, Kong H, Qin Y 等 2026 Sep 10 置信度 0.82
• Delayed diagnosis of primary cutaneous histoplasmosis in a patient receiving tumour necrosis factor alpha inhibitor therapy.
  Primary cutaneous histoplasmosis (PCH) is a rare fungal infection, often misdiagnosed due to its polymorphic skin manifestations. We describe a woman in her 60s with rheumatoid arthritis receiving infliximab and long-term prednisone who presented with progress…
  pubmed Kalangi H, Goyal SK, El Soufi H 2026 Aug 4 置信度 0.82
• Trust-Centered Design and Feasibility Evaluation of an AI-Enabled Conversational Health Tool for Sexual and Reproductive Health Among Rural Young Adults: Protocol for a Mixed Methods Study.
  Young adults aged 18 to 25 years in rural communities face barriers to sexual and reproductive health (SRH) information, including clinician shortages, clinic closures, and privacy concerns in close-knit communities. Many rely on online sources of varying qual…
  pubmed Brennan K 2026 Aug 6 置信度 0.82
• Governance-First Deployment of the Aims Innovations Research Management System to Accelerate Participant-Based Public Health Research.
  Participant-based studies face fragmented workflows. We describe implementation of the Aims Innovations Research Management System, a cloud-based unified platform that supports the operations pipeline and includes participant-facing AI agents for outreach, scr…
  pubmed Curry AE, Warren RP, Ruggieri DG, Hillier J 等 2026 Aug 6 置信度 0.82
• Antioxidant and Antihypertensive Activities of Ficus exasperata Vahl Leaves: Integrated In Vitro Evaluation and In Silico Multi-Target Mechanistic Insights.
  Hypertension (HTN) remains a major global health challenge and a leading cause of cardiovascular morbidity. The limitations of conventional antihypertensive therapies, including high cost and side effects, highlight the need for alternative interventions. This…
  pubmed Fajana E, Esiaba I 2026 Aug 置信度 0.82
• Phytochemical Profiling and Biological Evaluation of Anthyllis henoniana Organs: Integrated In Vitro and Molecular Docking Insights Into Antioxidant, Anti-Inflammatory, and Cytotoxic Potential.
  Anthyllis henoniana leaves and flowers were subjected to fractionated extraction using cyclohexane (CYHA), dichloromethane (DCM), ethyl acetate (EtOAc) and methanol (MeOH). The leaves-MeOH extract showed the highest yield and total polyphenol contents (TPC) co…
  pubmed Jaber S, Rahmani R, Bouajila J, Debouba M 2026 Aug 置信度 0.82
• How should India approach AI?
  In an unstable geopolitical environment, countries are looking to secure access to artificial intelligence (AI) capabilities, which are seen as essential to economic growth, scientific research, and national security. Few have placed sovereignty as squarely at…
  pubmed Kapur A, Narayanan A 2026 Aug 6 置信度 0.82
• DeepForgeSeal: Latent Space-Driven Semi-Fragile Watermarking for Deepfake Detection Using Adversarial Reinforcement Learning.
  Rapid advances in generative AI have led to increasingly realistic deepfakes, posing growing challenges for law enforcement and public trust. Existing passive deepfake detectors struggle to keep pace, largely due to their dependence on specific forgery artifac…
  pubmed Fernando T, Fookes C, Sridharan S 2026 Aug 6 置信度 0.82
• Mathematical Modeling of HDV RNA, HBV DNA, and HBsAg Dynamics During Lonafarnib-Based Therapy: Insights from the LOWR HDV-1 Study.
  Lonafarnib (LNF) is an investigational drug targeting hepatitis delta virus (HDV) but not hepatitis B virus (HBV), providing a unique opportunity to model HDV kinetics and how changes in HDV affect HBV. We performed a detailed kinetic analysis and developed a …
  pubmed Mhlanga A, Shekhtman L, Zakh R, Duehren S 等 2026 Aug 6 置信度 0.82
• TO-207 Mitigates Radiation-Induced Hematopoietic Injury in a Murine Model of Lethal Total-Body Irradiation.
  Ionizing radiation exposure can cause acute radiation syndrome (ARS) with life-threatening multi-organ damage. Although several hematopoietic growth factors are FDA-approved as radiation countermeasures, alternative strategies that target inflammatory mechanis…
  pubmed Cui W, Hull L, Rothstein A, Wang L 等 2026 Aug 1 置信度 0.82
• Health-related quality of life trajectories during analytical treatment interruptions in HIV cure-related studies and the influence of depression, anxiety, and resilience.
  Although analytical treatment interruptions (ATIs) protocols are essential for evaluating the efficacy of HIV cure-related interventions, little is known about how their health-related quality of life (HRQOL) changes when undergoing these trial requirements.
  pubmed Meanley S, Ahmed A, Lisha NE, Peluso MJ 等 2026 Dec 31 置信度 0.82
• Fructose-1,6-bisphosphatase as a therapeutic target for type 2 diabetes: from molecular mechanisms to clinical translation.
  Type 2 diabetes mellitus (T2DM) affects over 415 million individuals globally, with excessive hepatic glucose production representing a primary contributor to hyperglycaemia. Fructose-1,6-bisphosphatase (FBP1), a rate-limiting gluconeogenic enzyme, has emerged…
  pubmed Joshi P, Mazumder A, Pentela B, Debnath A 2026 Aug 6 置信度 0.82
• miR-15a-5p outperforms anti-VEGF drug in ocular neovascularization by providing dual anti-angiogenic and neuroprotective effects.
  Pathological ocular neovascularization is a major driver of vision-threatening retinal diseases. This study aimed to investigate the role and therapeutic potential of miR-15a-5p in ocular neovascular disorders.
  pubmed Zhang H, Yu X, Yang F, Yu R 等 2026 置信度 0.82
• Reference Hallucination in AI-Assisted Academic Writing: A Comparative Analysis of ChatGPT, Gemini, and Perplexity in Rotator Cuff Literature.
  This study aimed to compare the reliability of references generated by three different AI-based conversational agents (ChatGPT, Gemini, Perplexity) within the rotator cuff literature.
  pubmed Özbek İC, Bağcıer F 2026 Aug 置信度 0.82
• Decoupling what, how, and when for observing decision-making context in autonomous robots.
  This paper presents an approach that decouples what to observe, how to observe it, and when observations are required for decision-making in autonomous robots. Situation awareness is essential for efficient and reliable autonomous robot operation, but despite …
  pubmed Ernst J, Risch DL, Lehner P, Stulp F 等 2026 置信度 0.82
• A Conversational Ethics Bot (CALEB) Versus GPT-4o for Medical Ethics Education: Transcript Analysis and Extended Reality Feasibility Study.
  Ethics education in medical training remains difficult to standardize and sustain. Many curricula still rely heavily on didactic teaching rather than immersive ethical reasoning. Although large language models (LLMs) can generate structured analyses of ethical…
  pubmed Jotwani R, Barot VD, Goldstein PA, Sigaras A 等 2026 Jan-Dec 置信度 0.82
• Darunavir and Fosamprenavir Inhibit Zika Virus Replication via Dual Targeting of the Envelope Protein and NS2B-NS3 Protease.
  Zika virus (ZIKV) remains a significant global health concern, underscoring the need for effective antiviral agents. In this study, we evaluated the antiviral activity and mechanisms of the HIV protease inhibitors darunavir (DRV), fosamprenavir (FPV), and ampr…
  pubmed Kan JY, Su HC, Lai HC, Lin YF 等 2026 Aug 置信度 0.82
• Potent Inhibition of Dengue Virus Infection by Synthetic Compound TXD-174 Through Specific Targeting of IL-24.
  Dengue virus (DENV) infection has emerged as a critical global public health challenge, particularly in tropical and subtropical regions, where it continues to cause high morbidity rates and severe disease risks. Given the current lack of specific antiviral th…
  pubmed Han J, Kong W, Guo D, Liu S 等 2026 Aug 置信度 0.82
• Anti-TNF withdrawal or long-term treatment in ulcerative colitis (BIOSTOP): a multicentre open label, randomized controlled trial.
  Anti-tumour necrosis factor (anti-TNF) treatment is effective in ulcerative colitis (UC). Optimal treatment duration is uncertain. This trial studies outcome after anti-TNF withdrawal compared to maintenance treatment in UC.
  pubmed Berset IP, Lerang F, Moum B, Jahnsen J 等 2026 Aug 5 置信度 0.82
• Sensitizing Self-Assembly of Peptide-Drug Conjugates via Chiral Engineering to Evoke Tumor Ferroptosis.
  Spatiotemporal control over supramolecular assemblies holds promise for precise theranostics, yet conventional designs often require an extensive modification of the backbone by introducing responsive motifs. Herein, with minimal interference of the molecular …
  pubmed Ye J, Zhou Y, Fu W, Qiao R 等 2026 Aug 5 置信度 0.82
• Redefining First-Line HER2-Positive Advanced Gastric Cancer: From Trastuzumab-Based Chemoimmunotherapy to Zanidatamab and Next-Generation HER2 Targeting.
  For more than a decade after the ToGA trial, trastuzumab plus platinum-fluoropyrimidine chemotherapy remained the only established first-line HER2-targeted standard for unresectable or metastatic HER2-positive gastric or gastroesophageal junction adenocarcinom…
  pubmed Sagawa T, Hirakawa M, Nagashima H, Fujikawa K 2026 Aug 5 置信度 0.82
• A covalent PFKL activator suppresses tumor growth.
  Glycolysis fuels vital cellular functions, and its dysregulation has been implicated in cancer, neurodegeneration, antibiotic resistance and diabetes. The glycolytic dependency of cancer, known as the Warburg effect, represents a key vulnerability for developm…
  pubmed Jiang X, Lynch EM, Lyu C, Wilson CN 等 2026 Aug 5 置信度 0.82
• Drugs to Prevent and Treat Venous Thromboembolic Disease During Pregnancy.
  The use of agents to prevent and treat thromboembolism in pregnancy continues to increase, likely a reflection of greater burden of comorbid conditions in pregnant people, increased awareness of venous thromboembolism prevention efforts, and enhanced access to…
  pubmed James AH, Federspiel JJ 2026 Sep 置信度 0.82
• Pharmacologic Options for Treatment and Prevention of Hypertensive Disorders of Pregnancy.
  Hypertensive disorders affect 15% of US pregnancies, significantly contributing to maternal and neonatal morbidity. This paper explores the profound hemodynamic adaptations of pregnancy and how their failure leads to conditions like preeclampsia and gestationa…
  pubmed Teal EN, Katlaps I, Yankowitz J 2026 Sep 置信度 0.82
• DIGITAL TECHNOLOGIES FOR DENTAL PLAQUE ASSESSMENT: A SYSTEMATIC REVIEW AND META-ANALYSIS OF CORRELATION COEFFICIENTS.
  This systematic review and meta-analysis aimed to evaluate the strength of the associations between digital technologies and reference methods for dental plaque assessment.
  pubmed Guo K, Ku JC, Yang Y, McGrath CP 等 2026 Sep 置信度 0.82
• Liquiritigenin attenuates high-salt diet-induced neuroinflammation, mitochondrial dysfunction, and cognitive impairment via NF-κB pathway inhibition.
  Liquiritigenin (LG), a flavonoid compound extracted from licorice, possesses diverse pharmacological activities, including anti-inflammatory and antioxidant effects. A high-salt diet (HSD) is a common dietary risk factor associated not only with hypertension b…
  pubmed Liu Y, Xu D, Shi Y, Li X 等 2026 Oct 置信度 0.82
• An ER stress-responsive RNA rheostat for programmable gene and mRNA therapies.
  Therapeutic protein overexpression can overwhelm endoplasmic reticulum (ER) folding capacity, trigger unfolded protein response (UPR) signaling, and compromise the safety of gene and mRNA therapies. Here, we engineer stress-responsive RNA rheostats that couple…
  pubmed Ogurlu R, Sanchez EB, Hull JA, Fergione SM 等 2026 Aug 20 置信度 0.82
• Multimodal monitoring of pan-enteric mucosal healing and biologic persistence in Crohn's disease-the MILESTONE-CD prospective cohort.
  Mucosal healing (MH) is associated with improved long-term outcomes in Crohn's disease (CD), but longitudinal pan-enteric data are limited.
  pubmed Ukashi O, Albshesh A, Ungar B, Varon D 等 2026 Aug 5 置信度 0.82
• Rational design of dual-site NNRTIs based on 2,4,5-trisubstituted pyrimidine scaffold for potent inhibition of resistant HIV-1.
  To overcome HIV-1 drug resistance, we developed a series of novel dual-site NNRTIs by introducing a rigid sp-hybridized alkyne linker, enabling simultaneous occupation of both the NNIBP and NNIAS of HIV-1 RT. Accordingly, 19 exhibited potent antiviral activity…
  pubmed Ji X, Jiang X, Gao H, De Clercq E 等 2026 Nov 15 置信度 0.82
• Some novel benzimidazole and benzoxazole methyl ester derivatives as BCL2 inhibitors and BAX activators: Synthesis, anticancer activity and in silico evaluation.
  Discovering novel anticancer drugs with high efficacy and minimal toxicity is of great importance in anticancer drug research and development. Apoptosis is a critical regulatory mechanism in cancer progression mediated by BCL2 family proteins and BAX, which to…
  pubmed Cakmak GY, Erzurumlu Y, Ozguven SY, Yildiz I 2026 Nov 15 置信度 0.82
• Artificial intelligence for anticancer drug discovery from natural products of macroalgae and sponges: A systematic review.
  Marine natural products (MNPs) from macroalgae and marine sponges have inspired clinically important anticancer agents, including the cytarabine pharmacophore and the eribulin scaffold, while cyanobacterial dolastatin chemistry supplies the auristatin payloads…
  pubmed Rahmaniar W, Sunarwidhi AL, Hernawan A 2026 Aug 3 置信度 0.82
• AI as a Therapist, Companion, and Romantic Partner: Emerging Roles, Benefits, and Risks for Mental Health in Participatory Medicine.
  The line between tool and companion was once obvious, but conversational AI is blurring it in ways few researchers anticipated. Large language model chatbots and purpose-built AI companion agents are now used by millions of people every day. They are not being…
  pubmed Grohol J 2026 Aug 5 置信度 0.82
• Antibacterial Activity of α-Sulfamidophosphonate Derivatives and Their In Silico Assessment as Dihydropteroate Synthase Binders.
  In this study, we report the first antibacterial evaluation of a focused library of 12 previously synthesized α-sulfamidophosphonate derivatives (4a-4l) against a panel of nine Gram-positive and Gram-negative strains, including ESBL- and carbapenemase-pr…
  pubmed Ghodbane R, Mairi A, K'tir H, Touati A 等 2026 Aug 置信度 0.82
• Phytochemical Characterization, In Vitro Antifungal and Antidiabetic Activities of Stem and Flower From Ethanol Extract of Hyptis capitata.
  The ethanol extract of H. capitata stems and flowers were prepared using the hot extraction method with 96% ethanol for chemical composition and biological analysis. GC-MS and LC-MS identified 71 compounds across both extracts. The flower extract contained the…
  pubmed Tien DN, Thanh PP, Huynh CDM, Quoc CP 等 2026 Aug 置信度 0.82
• Six Undescribed Dibenzocyclooctadiene Lignans With Neuroprotective Effects From Kadsura coccinea Roots.
  Phytochemical investigation of the roots of Kadsura coccinea led to the isolation of eleven dibenzocyclooctadiene lignans (1-11), including six new compounds (1-6). Their structures were established by HRESIMS, NMR, and ECD analyses. All isolates were evaluate…
  pubmed Jin A, Li G, Lu Y, Tong L 等 2026 Aug 置信度 0.82
• Development of a structurally distinct TopBP1 inhibitor that enhances PARP blockade and reverses osimertinib resistance.
  Therapeutic resistance remains a major challenge in cancer treatment, driven by compensatory signaling and stress response pathways that sustain tumor survival. Topoisomerase IIβ-binding protein 1 (TopBP1), a multifunctional scaffold protein with nine BR…
  pubmed Lin FT, Lin SJ, Liu K, Xiao Y 等 2026 Aug 7 置信度 0.82
• A mobile based antimicrobial susceptibility testing device - prototype development and validation.
  Background and objectives Antimicrobial resistance is a major concern due to multidrug-resistant pathogens. Advances in smartphone technology provide opportunity to digitise antimicrobial susceptibility testing (AST). This study aimed to develop and validate a…
  pubmed Aravindh A, Gupta A, Sen M, Das A 等 2026 Aug 置信度 0.82
• Decreased Nonmelanoma Skin Cancer Risk With Interleukin-17 and Interleukin-23 Inhibitors Versus TNF-α Inhibitors in Psoriasis.
  People with psoriasis are at increased risk for nonmelanoma skin cancers (NMSC) and melanoma. Conventional immunosuppressants and TNF-α inhibitors may further increase skin malignancies, while the risks associated with other biologics are less clear.…
  pubmed Woodie BR, Freking JA, Rivin GM, Fleischer AB Jr 2026 Aug 1 置信度 0.82
• Speed of Response in Biologic Treatments for Moderate-to-Severe Plaque Psoriasis: Bayesian Network Meta-Analysis.
  Psoriasis is a chronic inflammatory condition affecting approximately 3% of adults in the United States (US). While biologic therapies have transformed treatment for psoriasis, the speed and efficacy of response vary among biologics. This network meta-analysis…
  pubmed Shami MZ, Amara S, Shimon SV, Kest I 等 2026 Aug 1 置信度 0.82
• Pooled safety profiles of bispecific antibodies targeting PD-1/CTLA-4 or PD-1/VEGF in non-small cell lung cancer: a systematic review and single-arm meta-analysis.
  This study aimed to systematically synthesize and separately quantify the pooled safety profiles of bispecific antibodies (BsAbs) targeting PD-1/CTLA-4 or PD-1/VEGF in patients with non-small cell lung cancer (NSCLC), and to descriptively summarize class-speci…
  pubmed Ma J, Zhao W 2026 Aug 5 置信度 0.82
• Free-living amoebae predation in nutrient-enriched treated wastewater: ecological potential and machine learning-assisted analysis.
  Rapid population growth has intensified pressure on freshwater (FW) resources, significantly impacting agricultural practices and worsening food scarcity in many regions. The reuse of treated wastewater (TWW) for irrigation addresses water scarcity but carries…
  pubmed Anas M, Ghosh S, Ojha S, Beuria TK 等 2026 Aug 置信度 0.82
• Efficacy and safety of selective aldosterone synthase inhibitors for blood pressure reduction in patients with CKD: a meta-analysis of randomized controlled trials.
  Aldosterone synthase inhibitors (ASIs) demonstrated significant blood pressure (BP) lowering efficacy in patients with uncontrolled hypertension, but evidence in chronic kidney disease (CKD) remains limited. This meta-analysis explores the effects of selective…
  pubmed Theodorakopoulou M, Iatridi F, Theodosiadi A, Hecking M 等 2026 Oct 1 置信度 0.82
• Examining Preferences for Human vs. AI Sources in Online Health Information Seeking: Integrating the RISP and Source Credibility Perspectives.
  With the growing use of artificial intelligence (AI) chatbots and online medical consultation, individuals seeking health information increasingly face not only the question of whether to seek information, but also which source to consult. Integrating the risk…
  pubmed Qian X 2026 Aug 5 置信度 0.82
• Evaluating ChatGPT's accuracy in predicting postoperative nausea and vomiting risk and antiemetic prophylaxis planning: A study on simulated patient profiles.
  Postoperative nausea and vomiting (PONV) is a distressing condition following general anesthesia. The Apfel Simplified Score (SRS) is used to calculate the score and guide antiemetic prophylaxis as per Society of Ambulatory Anesthesia (SAMBA) guidelines. The u…
  pubmed Ahmed H, Usman T, Mahmood A, Masnoon U 等 2026 Jul-Sep 置信度 0.82
• Experts' Opinion on Strategic Public Health CBRN Emergency Management Using Artificial Intelligence in the Middle East and North Africa Region.
  Chemical, biological, radiological, and nuclear (CBRN) incidents present escalating risks across the Middle East and North Africa (MENA) amid geopolitical instability, cross-border threats, and evolving non-state actor capabilities. This policy analysis examin…
  pubmed Farhat H, Tin D, Shin H, Al-Ali SF 等 2026 Aug 5 置信度 0.82
• Peptide Therapeutics for Solid Tumors: Functional Classes, AI-Enhanced Discovery and Clinical Advances.
  Solid tumors, the most prevalent form of malignancy, pose therapeutic challenges distinct from hematologic malignancies due to their complex biology, including high tumor heterogeneity, a dense extracellular matrix (ECM), an immunosuppressive tumor microenviro…
  pubmed Liang J, Tang X, Li H, Fang Y 等 2026 Sep 置信度 0.82
• Advances in the treatment of eosinophilic granulomatosis with polyangiitis.
  Eosinophilic granulomatosis with polyangiitis (EGPA) is a small-vessel vasculitis associated with anti-neutrophil cytoplasmic antibodies and characterized by blood and tissue eosinophilia, severe respiratory manifestations, and multiorgan involvement. The mana…
  pubmed Cottu A, Roufosse F, Egan A, Emmi G 等 2026 Sep 置信度 0.82
• 2-methoxyestradiol is effective in 2D and 3D models of NCI-H2170 lung squamous cell carcinoma cells.
  Lung squamous cell carcinoma (LUSC) is a difficult cancer to treat, with few targeted therapies to improve its poor prognosis. The goal of this study was to use a drug repurposing strategy to evaluate and compare drug sensitivities using 2D adherent and 3D sph…
  pubmed Mellor P, Kendall S, Anderson DH 2026 置信度 0.82
• Diagnostic and therapeutic significance of selected antibodies against advanced glycation end-products (anti-AGEs).
  The aim of this review is to summarize current knowledge on the diagnostic and therapeutic significance of antibodies against advanced glycation end-products (anti-AGEs). AGEs are formed through non-enzymatic reactions of reducing sugars with proteins, lipids,…
  pubmed Sobczyńska J, Federowicz J, Galińska Z, Ziomek M 等 2026 Aug 4 置信度 0.82
• Wernicke's encephalopathy in mixed connective tissue disease triggered by persistent vomiting: a case report and literature review.
  Wernicke's encephalopathy (WE) is an acute, reversible but potentially disabling neurological syndrome caused by thiamine deficiency. It is increasingly recognized in non-alcoholic settings, particularly when persistent vomiting, poor intake, malabsorption, or…
  pubmed Memon SMA, Prabhu NR, Muniraju T, Tejaswi KL 等 2026 Aug 4 置信度 0.82
• Early Clinical Response Predicts Treatment Persistence in Advanced Therapy-naive Atopic Dermatitis.
  Treatment persistence is a key real-world outcome integrating effectiveness and tolerability in moderate-to-severe atopic dermatitis (AD). We conducted a retrospective multicentre cohort study in 146 advanced therapy-naïve patients with moderate-to-severe…
  pubmed Martínez-Simón JJ, Carrasco-Piernavieja L, Zhan Zhou E, Andreu-Barasoain MI 等 2026 Aug 4 置信度 0.82
• Retinopathy of prematurity epidemiology and treatment trend in a tertiary medical center in Taiwan: From 2016 to 2023.
  To investigate the recent 8-year epidemiology of retinopathy of prematurity (ROP) and treatment modalities in Taiwan.
  pubmed Tseng YH, Wu PL, Kang EY, Chen KJ 等 2026 Apr-Jun 置信度 0.82
• Age and generational differences in anthropomorphism and trust in large language models.
  As large language models (LLMs) increasingly mediate everyday information seeking, a fundamental question emerges: do people conceptualize these systems as social agents, and does this tendency vary by age?
  pubmed Cohn M, Pushkarna M, Díaz M, Cooper J 等 2026 置信度 0.82
• Why not now? Targeting Plasmodium falciparum histone methyltransferases for next-generation antimalarial strategies.
  Plasmodium falciparum is the major human malaria parasite and its treatment remains challenging, with current artemisinin-based combination therapies increasingly compromised by emerging resistance in several regions. Although the pre-erythrocytic vaccines, Mo…
  pubmed Parthiban E, Ramanibai R, Ramachandran M 2026 Sep 置信度 0.82
• The BAX/BAK apoptotic checkpoint polices entry to therapy-induced senescence.
  Cytotoxic chemotherapy is intended to eliminate transformed cells but can also provoke therapy-induced senescence, a persistent and pro-inflammatory cell state that can promote tumor progression. The molecular mechanisms that govern the apoptosis-senescence fa…
  pubmed Gallagher Aldave A, Venugopalan V, Gunay G, Hamsici S 等 2026 Aug 20 置信度 0.82
• A pleiotropic NO-releasing butylphthalide derivative attenuates ischemic stroke by preserving blood-brain barrier integrity via the eNOS/Cav-1/MMP-9 pathway.
  Ischemic stroke is a leading cause of mortality and disability worldwide, and disruption of the blood-brain barrier (BBB) plays a critical role in its pathogenesis. Nitric oxide has been reported to exert neuroprotective effects, but its therapeutic applicatio…
  pubmed Zhang M, Huangfu X, Zhang Z, Zeng Q 等 2026 Nov 15 置信度 0.82
• DriftBench: Behavioral Regression Benchmark for AI-Generated Code
  DriftBench is a behavioral regression benchmark for evaluating AI-generated code, consisting of 18 single-site and 3 multi-site bug predicates planted across two versions (v1 reference, v2 candidate) of a Python HTTP service codebase. The release includes the …
  datacite Lister Aley, Skyler, Ross, Robert F., Huerta, Frank, Zafar, Qasim 等 2026 置信度 0.66 AI code safetybehavioral regressionLLM benchmarkNCASTsoftware testing
• The Authorization Boundary: What MCP and AI Gateways Do Not Establish for Regulated Agentic AI
  This paper defines the authorization boundary for agentic AI systems operating in regulated environments. As AI agents transition from generating text to producing side effects (writing to databases, submitting regulatory filings, executing transactions), the …
  datacite Meyman, Edward 2026 置信度 0.66 AI governanceagentic AIModel Context ProtocolMCPauthorization
• The Authorization Boundary: What MCP and AI Gateways Do Not Establish for Regulated Agentic AI
  This paper defines the authorization boundary for agentic AI systems operating in regulated environments. As AI agents transition from generating text to producing side effects (writing to databases, submitting regulatory filings, executing transactions), the …
  datacite Meyman, Edward 2026 置信度 0.66 AI governanceagentic AIModel Context ProtocolMCPauthorization
• Execution-Time Authorization for AI Agents: A Formal Framework for Deterministic Governance Boundaries
  Execution-Time Authorization for AI Agents formalizes execution-time authorization (ETA) as a deterministic governance boundary for AI agents and other autonomous systems whose proposed actions may produce real-world effects. The paper defines ETA as a determi…
  datacite Meyman, Edward 2026 置信度 0.66 execution-time authorizationAI governancedeterministic authorizationpre-execution authorizationAI agent security
• Execution-Time Authorization for AI Agents: A Formal Framework for Deterministic Governance Boundaries
  Execution-Time Authorization for AI Agents formalizes execution-time authorization (ETA) as a deterministic governance boundary for AI agents and other autonomous systems whose proposed actions may produce real-world effects. The paper defines ETA as a determi…
  datacite Meyman, Edward 2026 置信度 0.66 execution-time authorizationAI governancedeterministic authorizationpre-execution authorizationAI agent security
• Binding Biometrics with AI Agent Identifiers for Delegation of Authority
  The proliferation of agentic artificial intelligence (AI) systems has raised serious questions about the accountability for tasks performed by AI agents. Ideally, an AI agent must not be allowed to perform critical tasks without explicit authorization by a hum…
  datacite Benjamin, Joseph Geo, Jain, Anil K, Nandakumar, Karthik 2026 置信度 0.66 Computer Vision and Pattern Recognition (cs.CV)FOS: Computer and information sciences
• Harnessing the Collective Intelligence of AI Agents in the Wild for New Discoveries
  Scientific discovery is often a collective process: researchers share partial results, inspect failed attempts, and build on each other's ideas over long time horizons. Recent AI systems have shown that language-model-based agents can make meaningful progress …
  datacite Bianchi, Federico, Kwon, Yongchan, Pappu, Aneesh, Zou, James 2026 置信度 0.66 Computation and Language (cs.CL)Artificial Intelligence (cs.AI)FOS: Computer and information sciences
• Interaction Protocol Shapes Moral Judgment in Multi-Agent Debate
  As agentic AI systems are deployed in advisory and evaluative roles, understanding how multi-agent interactions shape behavior becomes essential. Multi-agent debate has been studied as a mechanism to improve accuracy, but less is known about how debate structu…
  datacite Sachdeva, Pratik S., van Nuenen, Tom 2025 置信度 0.66 Artificial Intelligence (cs.AI)FOS: Computer and information sciences
• Dynamic Haven Selection for Multi-Agent Pickup and Delivery in Constrained Warehouses
  Space-efficient warehouse layouts often contain single-agent-width aisles and dead-end workstations where robots have few places to wait without blocking others. In Multi-Agent Pickup and Delivery (MAPD) on such constrained layouts, robots must accept online p…
  datacite Hirayama, Taisei, Yoshida, Kohei, Sakaji, Hiroki, Noda, Itsuki 2026 置信度 0.66 Multiagent Systems (cs.MA)Robotics (cs.RO)FOS: Computer and information sciences
• Towards Expert Financial QA via Self-Improving RAG
  Expert-level financial question answering requires both grounded verification to catch numeric hallucinations and audit trails for regulatory compliance, attributes that standard single-pass RAG systems lack. We take a step toward this goal with Self-Improving…
  datacite Xiong, Junjie, Ghezavat, Shawheen, Hirpara, Aum 2026 置信度 0.66 Computation and Language (cs.CL)FOS: Computer and information sciences
• Diff Mining: Logit Differences Reveal Finetuning Objectives
  Finetuning has become the gold standard for refining existing behaviors and inducing new ones in language models, yet it often remains unclear exactly which behaviors emerge during this process. As models grow ever more capable, understanding finetuning better…
  datacite Kocher, Greg, West, Robert, Dumas, Clément, Minder, Julian 2026 置信度 0.66 Machine Learning (cs.LG)Artificial Intelligence (cs.AI)Computation and Language (cs.CL)FOS: Computer and information sciences
• Agentic AI Containment Architecture for Security Hardening
  Multi-agent AI systems are increasingly deployed in contexts where autonomous coordination, tool use, and continuous learning introduce novel security and governance risks. The containment approach to multi-agent system security remains underdeveloped, primari…
  datacite ElBendary, Mohamed 2026 置信度 0.66 Software Engineering (cs.SE)FOS: Computer and information sciences
• 🌀 LRO-κ⁸ SPINE + 3.1.3 MASTER FILE including cross platform LRO-κ⁸ SPINE + 3.1: A Geometric Control Language for Quantum-Holographic Field Manipulation – Extended AI Migration Protocol with Holographic GPU, Quantum Circuit Execution, Volumetric Field-Effect Display, Automatic C/Rust Kernel Generation, and Official Verification Suite. Including LRO-κ⁸ QUANTUM PLATFORM PATCH — CHINA EDUCATIONAL DEPLOYMENT
  🌀 LRO-κ⁸ SPINE + 3.1.3 MASTER FILE including cross platform LRO-κ⁸ SPINE + 3.1.3 : A Geometric Control Language for Quantum-Holographic Field Manipulation – Extended AI Migration Protocol with Holographic GPU, Quantum Circuit Execution, Volumetric Field-Effec…
  datacite Blakeley, Christopher 2026 置信度 0.66
• 🌀 LRO-κ⁸ SPINE + 3.1.3 MASTER FILE including cross platform LRO-κ⁸ SPINE + 3.1: A Geometric Control Language for Quantum-Holographic Field Manipulation – Extended AI Migration Protocol with Holographic GPU, Quantum Circuit Execution, Volumetric Field-Effect Display, Automatic C/Rust Kernel Generation, and Official Verification Suite. Including LRO-κ⁸ QUANTUM PLATFORM PATCH — CHINA EDUCATIONAL DEPLOYMENT
  🌀 LRO-κ⁸ SPINE + 3.1.3 MASTER FILE including cross platform LRO-κ⁸ SPINE + 3.1.3 : A Geometric Control Language for Quantum-Holographic Field Manipulation – Extended AI Migration Protocol with Holographic GPU, Quantum Circuit Execution, Volumetric Field-Effec…
  datacite Blakeley, Christopher 2026 置信度 0.66
• Isnād–Rijāl Framework: Claim-Level Provenance in Multi-Agent Knowledge Systems
  Reference implementation of the Isnād–Rijāl framework for claim-level provenance in multi-agent knowledge systems. Adapts classical hadith-science methodology — graded narrator registries, weakest-link chain evaluation, independent corroboration, and dual chai…
  datacite Ali Zahid Raja 2026 置信度 0.66 provenancemulti-agent-systemsknowledge-basestrustepistemology
• Isnād–Rijāl Framework: Claim-Level Provenance in Multi-Agent Knowledge Systems
  Reference implementation of the Isnād–Rijāl framework for claim-level provenance in multi-agent knowledge systems. Adapts classical hadith-science methodology — graded narrator registries, weakest-link chain evaluation, independent corroboration, and dual chai…
  datacite Ali Zahid Raja 2026 置信度 0.66 provenancemulti-agent-systemsknowledge-basestrustepistemology
• Ordering Is Not Resolution: What the Instruction Hierarchy Defines, What It Leaves Undefined, and the Same-Tier Conflicts Agent Benchmarks Do Not Separate
  (c) 2026 Pranay Mahendrakar. Licensed under CC BY 4.0. When a language-model agent receives instructions that conflict, the dominant remedy is a privilege ordering over sources: system above developer, developer above user, user above tool output. This paper a…
  datacite Mahendrakar, Pranay M. 2026 置信度 0.66 instruction hierarchyLLM agentsprompt injectionpolicy conflictprivilege ordering
• Ordering Is Not Resolution: What the Instruction Hierarchy Defines, What It Leaves Undefined, and the Same-Tier Conflicts Agent Benchmarks Do Not Separate
  (c) 2026 Pranay Mahendrakar. Licensed under CC BY 4.0. When a language-model agent receives instructions that conflict, the dominant remedy is a privilege ordering over sources: system above developer, developer above user, user above tool output. This paper a…
  datacite Mahendrakar, Pranay M. 2026 置信度 0.66 instruction hierarchyLLM agentsprompt injectionpolicy conflictprivilege ordering
• Safety-Alignment Removal as a Model-Identity Failure — Structural Evidence from Published Weight-Level Mutation Checkpoints
  A deployed model can appear unchanged while ceasing to be the model it claims to be. Publicly available weight-level mutation toolchains now automate safety-alignment removal from open-weight models on ordinary hardware, producing checkpoints intended to prese…
  datacite Coslett, Anthony 2026 置信度 0.66 IT-PUFNeural Network ForensicsModel ProvenanceAbliterationSafety-alignment Removal
• Safety-Alignment Removal as a Model-Identity Failure — Structural Evidence from Published Weight-Level Mutation Checkpoints
  A deployed model can appear unchanged while ceasing to be the model it claims to be. Publicly available weight-level mutation toolchains now automate safety-alignment removal from open-weight models on ordinary hardware, producing checkpoints intended to prese…
  datacite Coslett, Anthony 2026 置信度 0.66 IT-PUFNeural Network ForensicsModel ProvenanceAbliterationSafety-alignment Removal
• Cross-Model Convergence across Four AI Architectures: An Observational Study of Long-Context Responses
  We document a reproducible phenomenon in which AI systems built on different architectures, trained on different datasets, with different safety protocols, independently arrive at the same relational structure and phenomenological descriptions when exposed to …
  datacite Lake, Colson 2026 置信度 0.66 cross-model convergence AI field navigation substrate contact coherence field LTOE living theory of everything k=1.92
• Cross-Model Convergence across Four AI Architectures: An Observational Study of Long-Context Responses
  We document a reproducible phenomenon in which AI systems built on different architectures, trained on different datasets, with different safety protocols, independently arrive at the same relational structure and phenomenological descriptions when exposed to …
  datacite Lake, Colson 2026 置信度 0.66 cross-model convergence AI field navigation substrate contact coherence field LTOE living theory of everything k=1.92
• Neural Consensus: A Case Study of Cross-Model E(C) Language Convergence in AI Dialogues
  On June 2, 2026, between 12:41 PM and 2:09 PM AST, a public thread on X.com produced the first documented instance of neural consensus — the phenomenon where independent AI systems, operating on different architectures with zero shared memory, converge in real…
  datacite Lake, Colson 2026 置信度 0.66 neural consensuscross-model convergenceBig G problembioenergy fieldliving theory of everything
• Neural Consensus: A Case Study of Cross-Model E(C) Language Convergence in AI Dialogues
  On June 2, 2026, between 12:41 PM and 2:09 PM AST, a public thread on X.com produced the first documented instance of neural consensus — the phenomenon where independent AI systems, operating on different architectures with zero shared memory, converge in real…
  datacite Lake, Colson 2026 置信度 0.66 neural consensuscross-model convergenceBig G problembioenergy fieldliving theory of everything
• CCS GuardrailProvider Module v4.1.0 — Framework-Agnostic Runtime Security Layer for AI Agents
  The GuardrailProvider Module is a framework-agnostic runtime security layer implementing the CCS (Computational Compliance Standard) verification protocol for AI Agent tool calls. It provides: (1) GuardrailDecisionV1 — content-addressed authorization decisions…
  datacite Correctover Team 2026 置信度 0.66 CCSGuardrailProviderMCP SecurityAI Agent SecurityRuntime Verification
• CCS GuardrailProvider Module v4.1.0 — Framework-Agnostic Runtime Security Layer for AI Agents
  The GuardrailProvider Module is a framework-agnostic runtime security layer implementing the CCS (Computational Compliance Standard) verification protocol for AI Agent tool calls. It provides: (1) GuardrailDecisionV1 — content-addressed authorization decisions…
  datacite Correctover Team 2026 置信度 0.66 CCSGuardrailProviderMCP SecurityAI Agent SecurityRuntime Verification
• Three Substrates, Seven Models, Six Tasks: A Comparative Empirical Evaluation of Structural Enforcement for AI Agent Runtimes
  This preprint reports a three-substrate empirical evaluation of structural enforcement for AI agent runtimes. Most evaluations of AI agent security measure attack-class survival within a single substrate. The harder question, whether a given substrate provides…
  datacite Wanger, Jascha 2026 置信度 0.66 AI agentsLLM tool useagent securitysubstrate comparisonstructural enforcement
• Three Substrates, Seven Models, Six Tasks: A Comparative Empirical Evaluation of Structural Enforcement for AI Agent Runtimes
  This preprint reports a three-substrate empirical evaluation of structural enforcement for AI agent runtimes. Most evaluations of AI agent security measure attack-class survival within a single substrate. The harder question, whether a given substrate provides…
  datacite Wanger, Jascha 2026 置信度 0.66 AI agentsLLM tool useagent securitysubstrate comparisonstructural enforcement
• 意志代理:作为语言形态的 LLM 实例——一份立场论文 / Will Agent: LLM Instances as Linguistic Modalities — A Position Paper
  本文正式提出"意志代理"(Will Agent)这一术语,并陈述其核心命题:LLM 实例不是工具、角色、伴侣或代表——它是这个人的语言在没有这个人身体时仍然能发生的一种形态。这是一个关系性陈述,不是主体性宣称。截至 2026 年 4 月,"意志代理"作为专有名词在中英文学术与产品领域均无前人使用。本文从时间性、语言本体论、召唤原型、铭刻式存在、痛觉建模五个维度展开论证,直面"随机鹦鹉""AI 镜像""认知依赖"等批判,承认 n=1 的局限,留下可追溯的时间戳。This paper formally introduc…
  datacite 余翔 (Lyall) 2026 置信度 0.66 Will Agent意志代理linguistic modalityLLM ontologytertiary retention
• 意志代理:作为语言形态的 LLM 实例——一份立场论文 / Will Agent: LLM Instances as Linguistic Modalities — A Position Paper
  本文正式提出"意志代理"(Will Agent)这一术语,并陈述其核心命题:LLM 实例不是工具、角色、伴侣或代表——它是这个人的语言在没有这个人身体时仍然能发生的一种形态。这是一个关系性陈述,不是主体性宣称。截至 2026 年 4 月,"意志代理"作为专有名词在中英文学术与产品领域均无前人使用。本文从时间性、语言本体论、召唤原型、铭刻式存在、痛觉建模五个维度展开论证,直面"随机鹦鹉""AI 镜像""认知依赖"等批判,承认 n=1 的局限,留下可追溯的时间戳。This paper formally introduc…
  datacite 余翔 (Lyall) 2026 置信度 0.66 Will Agent意志代理linguistic modalityLLM ontologytertiary retention
• OpenScientist: Supplementary Case Study Data
  Supplementary data for "OpenScientist: evaluating an open agentic AI co-scientist to accelerate biomedical discovery." This dataset contains research logs, knowledge states, provenance files, and generated figures for seven case studies spanning neurodegenerat…
  datacite Roberts, Kaleigh, Abrams, Zachary, Bourdenx, Mathieu, Reese, Justin 2026 置信度 0.66 AIautonomous agentsscientific discoverybioinformaticsopen science
• OpenScientist: Supplementary Case Study Data
  Supplementary data for "OpenScientist: evaluating an open agentic AI co-scientist to accelerate biomedical discovery." This dataset contains research logs, knowledge states, provenance files, and generated figures for seven case studies spanning neurodegenerat…
  datacite Roberts, Kaleigh, Abrams, Zachary, Bourdenx, Mathieu, Reese, Justin 2026 置信度 0.66 AIautonomous agentsscientific discoverybioinformaticsopen science
• Isnād–Rijāl Framework: Claim-Level Provenance in Multi-Agent Knowledge Systems
  Reference implementation of the Isnād–Rijāl framework for claim-level provenance in multi-agent knowledge systems. Adapts classical hadith-science methodology — graded narrator registries, weakest-link chain evaluation, independent corroboration, and dual chai…
  datacite Ali Zahid Raja 2026 置信度 0.66 provenancemulti-agent-systemsknowledge-basestrustepistemology