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• Neural Dynamics of Tonic Cold Pain: A Novel Investigation of an In-Scanner Alternative to the Cold Pressor Test in Healthy Individuals
  The cold pressor task (CPT) is widely used to study tonic pain during acute and chronic conditions and is often as used as a conditioning stimulus to activate descending pain control systems. However, logistical challenges in magnetic resonance imaging (MRI) l…
  preprints 2024 置信度 0.74
• Replicating a High-Impact Scientific Publication Using Systems of Large Language Models
  Publications focused on scientific discoveries derived from analyzing large biological datasets typically follow the cycle of hypothesis generation, experimentation, and data interpretation. The reproduction of findings from such papers is crucial for confirmi…
  preprints 2024 置信度 0.74
• Formulation of Quinoa oil-alginate loaded nanoemulsion and its anticancer efficacy as a therapy for chemically induced breast cancer
  Quinoa seeds ( Chenopodium quinoa Willd.) have grown in interest due to their naturally occurring phytochemicals and antioxidants. It was stated that it has a powerful anticancer effect against human colorectal cancer. Gas chromatography-mass spectrometry was …
  preprints 2024 置信度 0.74
• Harnessing Medicinal Chemical Intuition from Collective Intelligence
  Abstract Over the last decade, the combination of collective intelligence with computational methods has transformed complex problem-solving. Here, we investigate if and how collective intelligence can be applied to drug discovery, focusing on the lead optimiz…
  preprints 2024 置信度 0.74
• Quorum Sensing Regulates Virulence Factors in the Coral Pathogen <i>Vibrio coralliilyticus</i>
  ABSTRACT The bacterial pathogen Vibrio coralliilyticus ( Vcor ) causes disease in coral species worldwide. The mechanisms of Vcor coral colonization, coral microbiome interactions, and virulence factor production are understudied. In other model Vibrio species…
  preprints 2024 置信度 0.74
• A multi-scale model to evaluate airport wastewater surveillance and ICU genomic monitoring for pandemic preparedness
  Increasing human mobility and population connectivity have intensified the risks of global pathogen spread, while concurrent shifts in human demographic patterns, ecological factors, and climatic conditions have altered the global landscape of this risk. Genom…
  preprints 2026 置信度 0.74
• Multi-isolate GWAS identifies broad-spectrum and isolate-specific Septoria tritici blotch resistance loci in synthetic hexaploid wheat
  Abstract Septoria tritici blotch (STB), caused by Zymoseptoria tritici , remains a major constraint on wheat production worldwide. Erosion of host resistance and declining fungicide efficacy highlight the need to exploit the new sources of resistance, includin…
  preprints 2026 置信度 0.74
• Mechanistic Language Modeling and Oxygenated 3D Screening Reveal Berberine and Enzalutamide Synergy in Resistant Prostate Cancer
  ABSTRACT Resistance to androgen receptor inhibitors remains a primary challenge in prostate cancer treatment, yet identifying synergis-tic co-therapies is hindered by immense combinatorial search spaces and the limited interpretability of predictive computatio…
  preprints 2026 置信度 0.74
• Reconstituting Placenta–Embryo Crosstalk in a Microfluidic Chip for Human‑Relevant Developmental Toxicity Studies
  Abstract Developmental toxicity assessment currently relies predominantly on in vivo animal studies that provide limited mechanistic insights into human-relevant effects of drugs, nanoparticles (NPs), or environmental pollutants during pregnancy. To bridge thi…
  preprints 2026 置信度 0.74
• Using a Metadata Approach to Extend the Functional Resonance Analysis Method to Model Quantitatively, Emergent Behaviours in Complex Systems.
  In an increasingly complex world there is a real, urgent need for methodologies to enable engineers to model complex sociotechnical systems, as these now seem to describe the majority of systems in use today. This is of course exacerbated by the increasing inv…
  preprints 2024 置信度 0.74
• Interactions between the 2C protein of FMDV and components of the viral replication machinery are mediated by ER-derived membranes
  Foot-and-mouth disease virus (FMDV) remains an ever-present threat to the economic stability of the livestock industry and global trade. Despite this, questions remain regarding the fundamental biology underpinning the replication of this virus. Here, we exami…
  preprints 2025 置信度 0.74
• Biodegradation of polyethylene (PE), polypropylene (PP), and polystyrene (PS) microplastics by floc-forming bacteria, Bacillus cereus strain SHBF2 isolated from a commercial aquafarm
  Abstract The ubiquitous proximity of the commonly used microplastic (MP) particles particularly polyethylene (PE), polypropylene (PP), and polystyrene (PS) poses a serious threat to the environment, and human health globally. Biological treatment as an environ…
  preprints 2024 置信度 0.74
• Personalised approach to hypertension treatment: Rationale and design of the HYPERMARKER randomised trial
  ABSTRACT Background and Objective Blood pressure treatment response is variable in individual patients, and the choice of medical therapy is often dependent on clinician experience. Treatment choices can be personalised by patient empowerment, metabolomic prof…
  preprints 2026 置信度 0.74
• Postpartum management of the hypertensive disorders of pregnancy
  Abstract Objective : To assess the effectiveness and safety of management strategies for postpartum hypertension. Data sources : We searched the Cochrane Pregnancy and Childbirth’s Trials Register in collaboration with their Information Specialist, on 20/Octob…
  preprints 2025 置信度 0.74
• CAT Bridge: An Efficient Toolkit for Gene-Metabolite Association Mining from Multi-Omics Data
  Background With advancements in sequencing and mass spectrometry technologies, multi-omics data can now be easily acquired for understanding complex biological systems. Nevertheless, substantial challenges remain in determining the association between gene-met…
  preprints 2024 置信度 0.74
• Deep learning integration of ultrasound perfusion and stiffness maps predicts tumor response to treatment
  Abstract The complex tumor microenvironment and tumor heterogeneity make treatment responses highly variable, driving the shift toward biomarker-based therapy prediction. Ultrasound shear wave elastography (SWE) provides a simple and non-invasive method to mea…
  preprints 2025 置信度 0.74
• Understanding dynamics to Streamline Access: Systems Engineering and Agent-Based Probabilistic Modelling in Memory Assessment Services
  Abstract Background As the global population ages, healthcare systems must anticipate and manage the interactions of older adults with dementia and other long-term conditions. Optimising dementia assessment and diagnosis services is essential to enhance effici…
  preprints 2025 置信度 0.74
• Using artificial intelligence to optimize ecological restoration for climate and biodiversity
  The restoration of degraded ecosystems is critical for mitigating climate change and reversing biodiversity loss. Depending on the primary objective – such as maximizing carbon sequestration or protecting threatened species – and within the boundaries of budge…
  preprints 2025 置信度 0.74
• Circulating tumour DNA dynamics during alternating chemotherapy and hormonal therapy in metastatic breast cancer: the ALERT study
  Purpose: Although changes in circulating tumour DNA (ctDNA) in breast cancer are well described, the kinetics of their fluctuations has not been described over short timescales. We investigated ctDNA dynamics during alternating cycles of chemotherapy and hormo…
  preprints 2024 置信度 0.74
• Expanding molecular diagnostic coverage for tuberculosis by combining computer-aided chest radiography and sputum specimen pooling: a modeling study from four high burden countries
  Background: In 2022, fewer than half of persons with tuberculosis (TB) have access to molecular diagnostic tests for TB due to their high costs. Studies have found that computer-aided detection using artificial intelligence (AI) for chest X-ray (CXR) and sputu…
  preprints 2024 置信度 0.74
• A mHealth intervention (mTB-Tobacco) for smoking cessation in people with drug-sensitive pulmonary tuberculosis: protocol for an adaptive design, cluster randomised controlled trial (Quit4TB)
  ABSTRACT Introduction People with tuberculosis (TB) who continue to smoke are more likely to have poor health outcomes than those who quit. Established smoking cessation approaches such as mHealth may help TB patients quit smoking. This paper summarises the me…
  preprints 2024 置信度 0.74
• Behavioral Time Scale Synaptic Plasticity (BTSP) endows binding of distributed representations with flexible retrieval options
  Human reasoning depends on reusing pieces of information by binding them together in new ways, thereby “making infinite uses of finite means” (Alexander von Humboldt). Needed for that is a binding mechanism that enables fast composition and decomposition of to…
  preprints 2025 置信度 0.74
• Deep reinforcement learning for active flow control in a turbulent separation bubble
  Abstract The control efficacy of deep reinforcement learning (DRL) compared with classical periodic forcing is assessed for a turbulent separation bubble (TSB) reaching a friction Reynolds number of Re 𝝉 =750. The TSB is a simplified representation of the sep…
  preprints 2024 置信度 0.74
• Complement receptor <i>C3ar1</i> deficiency does not alter brain structure or functional connectivity across early life development
  Genetic deletion of the complement C3a anaphylatoxin chemotactic receptor ( C3ar1 ), a key component of the innate immune response, is reported to induce behavioural phenotypes consistent with psychiatric symptomatology in mice, but when and where C3ar1 is nee…
  preprints 2025 置信度 0.74
• Comparative Genomics of Giardia duodenalis Sub-assemblage A1 Beaver (Be-2) and Human (WB-C6) Strains Show Remarkable Homozygosity, Sequence Similarity, and Conservation of VSP Genes
  Giardia duodenalis , a major cause of waterborne infection, infects a wide range of mammalian hosts and is subdivided into eight genetically well-defined assemblages named A through H. However, fragmented genomes and a lack of comparative analysis within and b…
  preprints 2024 置信度 0.74
• Dynamic Mortality Prediction in Critically Ill Children during Inter-hospital Transports to PICUs Using Explainable AI
  Abstract Critically ill children who require inter-hospital transfers to Paediatric Intensive Care Units (PICUs) are sicker than other admissions and have higher mortality rates. Accurate identification of severely ill patients at risk of high mortality is cru…
  preprints 2024 置信度 0.74
• Embodied decisions as active inference
  Decision-making is often conceptualized as a serial process, during which sensory evidence is accumulated for the choice alternatives until a certain threshold is reached, at which point a decision is made and an action is executed. This decide-then-act perspe…
  preprints 2024 置信度 0.74
• An Organotypic Oral Squamous Cell Carcinoma Model Recapitulates Epithelial-Stromal Complexity at Single-cell Resolution and Reveals Matrix-derived Signalling as a Therapeutic Target
  ABSTRACT Three-dimensional (3D) organotypic cultures recapitulate key structural features of oral tumours and provide controlled, ethical, and reproducible research platforms. However, their ability to faithfully recapitulate in vivo tissue composition and the…
  preprints 2026 置信度 0.74
• Integrating behavioral experimental findings into dynamical models to inform social change interventions
  Abstract Addressing global challenges – from public health to climate change – often involves stimulating the large-scale adoption of new products or behaviors. Research traditions that focus on individual decision making suggest that achieving this objective …
  preprints 2024 置信度 0.74
• Plaque Recognition and Classification Algorithm for CCTA Image Sequences with Frame-Gradient of Gaussian Variance
  Abstract Coronary computed tomography angiography (CCTA) is the most commonly used image acquisition method for the diagnosis of cardiovascular disease (CVD) currently. While plaque recognition and classification based on CCTA image sequences are the most comm…
  preprints 2024 置信度 0.74
• A convolutional attention model for predicting response to chemo-immunotherapy from ultrasound elastography in mouse tumor models
  Abstract Background. In the era of personalized cancer treatment, understanding the intrinsic heterogeneity of tumors is crucial. Despite some patients responding favorably to a particular treatment, others may not benefit, resulting in varied efficacy of stan…
  preprints 2024 置信度 0.74
• Machine learning to predict antibiotic susceptibility in Enterobacterales bloodstream infections compared to clinician prescribing
  Background Patients with Gram-negative bloodstream infections are at risk of serious adverse outcomes without active treatment, but identifying who has antimicrobial resistance (AMR) to target empirical treatment is challenging. Methods We used XGBoost machine…
  preprints 2024 置信度 0.74
• DNA Damage Response Proteins Are Involved in the Formation of Defective HIV-1 Proviruses
  Latent HIV-1 proviruses remain the major barrier to curing HIV infection. Although many of these proviruses are defective, with large internal deletions and hypermutations, the mechanisms underlying their formation are still poorly understood. In this study, w…
  preprints 2026 置信度 0.74
• Mitigating Machine Learning Bias Between High Income and Low-Middle Income Countries for Enhanced Model Fairness and Generalizability
  Collaborative efforts in artificial intelligence (AI) are increasingly common between high-income countries (HICs) and low-to middle-income countries (LMICs). Given the resource limitations often encountered by LMICs, collaboration becomes crucial for pooling …
  preprints 2024 置信度 0.74
• Endothelial Sensitivity to Pro-Fibrotic Signals Links Systemic exposure to Pulmonary Fibrosis
  Summary Pulmonary fibrosis (PF) is a life-threatening condition characterised by excessive extracellular matrix deposition and tissue scarring. While much of PF research has focused on alveolar epithelial cells and fibroblasts, endothelial cells have emerged a…
  preprints 2025 置信度 0.74
• Chromosome-level Assemblies of Three Candidatus Liberibacter solanacearum Vectors: Dyspersa apicalis, Dyspersa pallida, and Trioza urticae (Hemiptera: Psylloidea)
  Psyllids are major vectors of plant diseases, including Candidatus Liberibacter solanacearum (CLso), the bacterial agent associated with 'zebra chip' disease in potatoes and 'carrot yellows' disease in carrot. Despite their agricultural significance, there is …
  preprints 2024 置信度 0.74
• Direct binding of TDP-43 and Tau drives their co-condensation, but suppresses Tau fibril formation and seeding
  Neuronal Tau aggregates are a hallmark of Alzheimer’s disease (AD), but more than half of the patients exhibit additional TDP-43 inclusions and some have co-aggregates of both proteins. The presence of Tau/TDP-43 co-pathology is associated with increased disea…
  preprints 2025 置信度 0.74
• A-eye: Automated 3D MRI Segmentation and Morphometric Feature Extraction for Eye and Orbit Atlas Construction
  In this study we introduce an automated 3D segmentation of the healthy human adult eye and orbit from Magnetic Resonance Images, to improve ophthalmic diagnostics and treatments. Past efforts primarily focused on small sample sizes and varied imaging modalitie…
  preprints 2024 置信度 0.74
• Hepatitis B Virus (HBV) treatment eligibility in the UK: retrospective longitudinal cohort data to explore the impact of changes in clinical guidelines
  ABSTRACT Objective Nucleos/tide analogue (NA) drugs are used for the long-term treatment of chronic hepatitis B virus (HBV) infection. In a landscape of changing clinical recommendations, we set out to quantify the prescription of NA drugs to date, and to dete…
  preprints 2024 置信度 0.74
• Amoebic gill disease (AGD) in Atlantic salmon investigated through a holo-omic lens
  ABSTRACT Interactions between host genetics and the resident microbiota are complex. Understanding these interactions offers interesting alternatives for addressing gill health and disease resistance in salmonids. Amoebic gill disease (AGD), caused by Neoparam…
  preprints 2025 置信度 0.74
• Is Hsp110 boosting the basal disaggregation activity Hsp70 by enhanced entropic pulling strokes?
  Hsp70s use energy from ATP hydrolysis to unfold protein structures and solubilize stable aggregates, accumulating native species even under adverse non-native conditions. To carry out its catalytic polypeptide-unfolding activity, Hsp70 needs to reversibly inte…
  preprints 2025 置信度 0.74
• Balancing safety and efficiency in human decision making
  ABSTRACT The safety-efficiency dilemma describes the problem of maintaining safety during efficient exploration and is a special case of the exploration-exploitation dilemma in the face of potential dangers. Conventional exploration-exploitation solutions coll…
  preprints 2024 置信度 0.74
• Single-cell approach dissecting <i>agr</i> quorum sensing dynamics in <i>Staphylococcus aureus</i>
  Staphylococcus aureus both colonizes humans and causes severe virulent infections. Virulence is regulated by the agr quorum sensing system and its autoinducing peptide (AIP), with dynamics at the single-cell level across four agr -types – each defined by disti…
  preprints 2024 置信度 0.74
• Tmn blocks phage spread via plasmolysis and triggers synergistic defence responses
  Membrane-associated phage defences remain poorly understood. Here we characterise Tmn, a YobI-family transmembrane P-loop NTPase that protects bacteria from phage infection by establishing a plasmolysis-associated antiviral state. Upon recognising phage T2 RII…
  preprints 2026 置信度 0.74
• Polyploid cardiomyocytes define disease-specific transcriptional states in the mammalian heart
  The adult mammalian heart has a limited regenerative capacity. Following injury, cardiomyocytes undergo a hypertrophic response accompanied by polyploidization, which has been described as a barrier to proliferation and regeneration of the heart 1,2 . However,…
  preprints 2026 置信度 0.74
• Influence of Major Trauma and Lower Limb Loss on Radiographic Progression and Incidence of Knee Osteoarthritis and Pain: A Comparative and Predictive Analysis from the ADVANCE Study 
  Abstract Objective: Knee osteoarthritis (OA) is a leading cause of disability globally, with previous injury a key risk factor. This study investigates the relationship between the risk of progression and incidence of knee radiographic OA (rOA) and pain (KP) w…
  preprints 2025 置信度 0.74
• Modelling practices, data provisioning, sharing and dissemination needs for pandemic decision-making: a European survey-based modellers’ perspective
  Introduction Advanced outbreak analytics played a key role in governmental decision-making as the COVID-19 pandemic challenged health systems globally. This study assessed the evolution of European modelling practices, data usage, gaps, and interactions betwee…
  preprints 2025 置信度 0.74
• MAGELLAN: Automated Generation of Interpretable Computational Models for Biological Reasoning
  Computational models have become essential tools for understanding signalling networks and their non-linear dynamics. However, these models are typically constructed manually using prior knowledge and can be over-reliant on study bias. These limitations hinder…
  preprints 2025 置信度 0.74
• Dicarbonyl stress debilitates mesothelial defense against metastasizing ovarian cancer
  Chronic metabolic disorders and aging result in accumulation of active dicarbonyls that glycate biomolecules rendering them dysfunctional. Although metabolic aberrations are known to be epidemiologically associated with faster cancer progression, cell biologic…
  preprints 2024 置信度 0.74
• Signatures of omicron-like adaptation in early SARS-CoV-2 variants and chronic infection
  SUMMARY Omicron emergence represented a seismic event in the COVID-19 pandemic, demonstrating what was essentially antigenic shift in a virus that cannot reassort its genome as influenza can. Understanding the success of Omicron is essential, and yet we have l…
  preprints 2024 置信度 0.74
• The oncogene SLC35F2 is a high-specificity transporter for the micronutrients queuine and queuosine
  The nucleobase queuine (q) and its nucleoside queuosine (Q) are micronutrients derived from bacteria that are acquired from the gut microbiome and/or diet in humans. Following cellular uptake, Q is incorporated at the wobble base (position 34) of tRNAs with a …
  preprints 2024 置信度 0.74
• VISION — an open-source software for automated multi-dimensional image analysis of cellular biophysics
  Environment-sensitive probes are frequently used in spectral/multi-channel microscopy to study alterations in cell homeostasis. However, the few open-source packages available for processing of spectral images are limited in scope. Here, we present VISION, a s…
  preprints 2024 置信度 0.74
• Cap-independent co-expression of dsRNA-sensing and NF-κB pathway inhibitors enables tunable self-amplifying RNA expression with reduced immunotoxicity
  ABSTRACT Self-amplifying RNA (saRNA) has the potential to provide durable, non-integrating transgene expression for transient gene therapy. However, its auto-replicative nature mimics viral infection, triggering innate immune responses that shut down cap-depen…
  preprints 2024 置信度 0.74
• Reprogramming Human Inflammatory Macrophages in Symptomatic Carotid Stenosis: Potential Mechanisms for Stabilisation of Atherosclerotic Carotid Plaques
  Background Inflammation is a precursor to atherosclerotic plaque destabilisation, leading to ischaemic events such as stroke. Macrophage phenotypes can be altered by the microenvironment, and certain anti-inflammatory agents may, therefore, stabilise plaques a…
  preprints 2024 置信度 0.74
• Sex-dependent additive effects of dorzagliatin and incretin on insulin secretion in a novel mouse model of <i>GCK</i> -MODY
  Glucokinase (GK) catalyses the key regulatory step in glucose-stimulated insulin secretion. Correspondingly, hetero– and homozygous mutations in human GCK cause maturity-onset diabetes of the young (GCK-MODY) and permanent neonatal diabetes (PNDM), respectivel…
  preprints 2024 置信度 0.74
• MONFIT: Multi-omics factorization-based integration of time-series data sheds light on Parkinson’s disease
  Parkinson’s disease (PD) is a severe and complex multifactorial neurodegenerative disease with still elusive pathophysiology preventing the development of curative treatments. Molecular deep phenotyping by longitudinal multi-omics is a promising approach to id…
  preprints 2024 置信度 0.74
• Non-invasive MRI of Blood-Cerebrospinal Fluid-Barrier Function: a Functional Biomarker of Early Alzheimer’s Disease Pathology
  INTRODUCTION Choroid plexus (CP) dysfunction is thought to contribute to toxic protein build-up in neurodegenerative disorders, including Alzheimer’s disease (AD). However, the dynamics of this process remain unknown, mainly due to the paucity of in-vivo metho…
  preprints 2024 置信度 0.74
• Comprehensive profiling of anaesthetised brain dynamics across phylogeny
  Intrinsic dynamics of neuronal circuits shape information processing. Combining neuroimaging with causal perturbation offers the opportunity to understand how local dynamics mediate the link between neurobiology and functional repertoire. We compile a unique d…
  preprints 2025 置信度 0.74
• <i>M. tuberculosis</i> meets European Lead Factory – identification and structural characterization of novel Rv0183 inhibitors using X-ray crystallography
  Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of mortality worldwide. Proteins involved in lipid metabolism, such as the monoacylglycerol lipase Rv0183, play critical roles during both the active and dormant phases of Mtb an…
  preprints 2025 置信度 0.74
• Exome sequencing and analysis of 44,028 British South Asians enriched for high autozygosity
  Genes and Health (G&H) is a biomedical study of adult British-Pakistani and -Bangladeshi research volunteers enriched for autozygosity. We performed whole exome sequencing in 44,028 G&H participants, establishing the largest publicly available South Asian exom…
  preprints 2025 置信度 0.74
• Inter-kingdom signaling by the <i>Legionella</i> autoinducer LAI-1 involves the antimicrobial guanylate binding protein GBP
  The causative agent of Legionnaires’ disease, Legionella pneumophila , is an amoebae-resistant environmental bacterium, which replicates intracellularly in a distinct compartment, the “ Legionella -containing vacuole” (LCV). L. pneumophila employs the α-hydrox…
  preprints 2024 置信度 0.74
• Methylthio-alkane reductases use nitrogenase metalloclusters for carbon-sulfur bond cleavage
  Methylthio-alkane reductases convert methylated sulfur compounds to methanethiol and small hydrocarbons, a process with important environmental and biotechnological implications. These enzymes are classified as nitrogenase-like enzymes, despite lacking the abi…
  preprints 2024 置信度 0.74
• Golgins support extracellular matrix secretion by collectively maintaining the Golgi structure-function relationship
  The secretion of extracellular matrix (ECM) proteins is vital to the maintenance of tissue health. One major control point of this process is the Golgi apparatus, whose dysfunction causes numerous connective tissue disorders. Golgi function is tightly linked t…
  preprints 2024 置信度 0.74
• Multi-center benchmarking of cervical spinal cord RF coils for 7 T MRI: A traveling spines study
  Purpose The depth within the body, small diameter, long length, and varying tissue surrounding the spinal cord impose specific considerations when designing radiofrequency coils. The optimal coil configuration for 7 T cervical spinal cord MRI is unknown and, c…
  preprints 2025 置信度 0.74
• Single-cell spatial atlas of high-grade serous ovarian cancer unveils MHC class II as a key driver of spatial tumor ecosystems and clinical outcomes
  The tumor microenvironment (TME) is a complex network of interactions between malignant and host cells, yet its orchestration in advanced high-grade serous ovarian carcinoma (HGSC) remains poorly understood. We present a comprehensive single-cell spatial atlas…
  preprints 2024 置信度 0.74
• The PAZ domain of <i>Aedes aegypti</i> Dicer 2 is critical for accurate and high-fidelity size determination of virus-derived small interfering RNAs
  ABSTRACT The exogenous siRNA (exo-siRNA) pathway is a critical RNA interference response involved in controlling arbovirus replication in mosquito cells. It is initiated by the detection of viral long double-stranded RNA (dsRNA) by the RNase III enzyme Dicer 2…
  preprints 2024 置信度 0.74
• Targeted long-read RNA sequencing reveals the complexity of <i>CLN3</i> transcription and the consequences of the most common 1-kb deletion in patients with juvenile CLN3 disease
  Most genes are not yet fully annotated, and the extent of their transcript diversity and the roles and significance of specific isoforms is not understood. This information is therefore lacking for disease genes. The CLN3 gene underlies classic juvenile CLN3 d…
  preprints 2025 置信度 0.74
• Nucleotidyltransferase toxin MenT targets and extends the aminoacyl acceptor ends of serine tRNAs <i>in vivo</i> to control <i>Mycobacterium tuberculosis</i> growth
  ABSTRACT Toxins of toxin-antitoxin systems use diverse mechanisms to control bacterial growth and represent attractive therapeutic targets to fight pathogens. In this study, we characterized the translation inhibitor toxin MenT3 of Mycobacterium tuberculosis ,…
  preprints 2024 置信度 0.74
• A comprehensive pharmacological survey across heterogeneous patient-derived GBM stem cell models
  Despite substantial drug discovery investments, the lack of any significant therapeutic advancement in the treatment of glioblastoma (GBM) over the past two decades calls for more innovation in the identification of effective treatments. The inter-and intra-pa…
  preprints 2024 置信度 0.74
• Competitive interactions shape brain dynamics and computation across species
  Adaptive cognition relies on cooperation across anatomically distributed brain circuits. However, specialised neural systems are also in constant competition for limited processing resources. How does the brain's network architecture enable it to balance these…
  preprints 2024 置信度 0.74
• Cell states and neighborhoods in distinct clinical stages of primary and metastatic esophageal adenocarcinoma
  Esophageal adenocarcinoma (EAC) is a highly lethal cancer of the upper gastrointestinal tract with rising incidence in western populations. To decipher EAC disease progression and therapeutic response, we performed multiomic analyses of a cohort of primary and…
  preprints 2024 置信度 0.74
• The origins of haplotype 58 (H58) Salmonella enterica serovar Typhi
  Abstract Antimicrobial resistance (AMR) poses a serious threat to the clinical management of typhoid fever. AMR in Salmonella Typhi ( S . Typhi) is commonly associated with the H58 lineage, a lineage that arose comparatively recently before becoming globally d…
  preprints 2024 置信度 0.74
• Reduced Non-Specific Binding of Super-Resolution DNA-PAINT Markers by Shielded DNA-PAINT Labeling Protocols
  The DNA-based single molecule super-resolution imaging approach, DNA-PAINT, can achieve nanometer resolution of single targets. However, the approach can suffer from significant non-specific background signals originating from non-specifically bound DNA-conjug…
  preprints 2024 置信度 0.74
• Lessons from ArriveCAN: Access to Information and Justice during a Glitch
  In summer 2022, ArriveCAN, Canada's border app mandated during the COVID-19 pandemic for travelers entering the country, began sending certain users erroneous notifications to quarantine. On July 14, 2022, the federal government identified a glitch that was re…
  preprints 2022 置信度 0.74
• Phollow: Visualizing Gut Bacteriophage Transmission within Microbial Communities and Living Animals
  ABSTRACT Bacterial viruses (known as “phages”) shape the ecology and evolution of microbial communities, making them promising targets for microbiome engineering. However, knowledge of phage biology is constrained because it remains difficult to study phage tr…
  preprints 2024 置信度 0.74
• Spatiotemporal visualization of DNA replication by click chemistry reveals bubbling of viral DNA in virion formation
  The organisation of human chromosomes reversibly changes in cell division, and irreversibly in apoptosis or erythropoiesis by DNA condensation and fragmentation processes. Yet, how viral replication in the nucleus affects host and viral chromatin organisation …
  preprints 2024 置信度 0.74
• Mapping the Use of Facial Recognition in Public Spaces in Europe – Part 3: Facial Recognition for Authorisation Purposes
  This is the 1st ever detailed analysis of what is the most widespread way in which Facial Recognition is used in public ( and private) spaces: for authorization purposes. This 3rd Report in our #MAPFRE series should be of great interest to lawyers interested i…
  preprints 2022 置信度 0.74
• Digital Public Space – A Missing Policy Frame for Shaping Europe's Digital Future
  The 2030 Digital Compass, a key European Union strategic document that defines a digital policy for this decade, opens with a sketch of the current context: the COVID-19 pandemic. It mentions that technologies are now imperative in all fields of social life, a…
  preprints 2021 置信度 0.74
• Engineering multivalent Fc display for FcγR blockade
  ABSTRACT Autoimmune diseases, driven by Fcγ receptor (FcγR) activation through autoantibody immune complexes (IC), present a complex therapeutic challenge of achieving pharmacological blockade of FcγR without triggering receptor activation. The assembly of ICs…
  preprints 2024 置信度 0.74
• Synaptic deregulation of cholinergic projection neurons causes olfactory dysfunction across 5 fly Parkinsonism models
  The classical diagnosis of Parkinsonism is based on motor symptoms that are the consequence of nigrostriatal pathway dysfunction and reduced dopaminergic output. However, a decade prior to the emergence of motor issues, patients frequently experience non-motor…
  preprints 2023 置信度 0.74
• Universal Access to Clean Water for Tribes: Recommendations for Operational, Administrative, Policy, and Regulatory Reform
  Access to clean drinking water is a fundamental human right. As highlighted by the COVID-19 pandemic, basic water and sanitation services are critical to public health and economic development. The federal government has treaty and trust responsibilities to pr…
  preprints 2021 置信度 0.74
• The Impact of Overseas Warehouse on Cross-Border E-Commerce Exports from the Perspective of System Dynamics
  The novel coronavirus pneumonia epidemic is still raging around the world. Therefore, during the period of a global pandemic, maintaining the normal circulation of medicine and health fields is the key to fight against the epidemic. This paper based on relevan…
  preprints 2021 置信度 0.74
• Will Vaccine-derived Protective Immunity Curtail COVID-19 Variants in the US?
  ABSTRACT Multiple effective vaccines are currently being deployed to combat the COVID-19 pandemic, and are viewed as the major factor in marked reductions of disease burden in regions with moderate to high vaccination coverage. The effectiveness of COVID-19 va…
  preprints 2021 置信度 0.74
• Government & Economics 4.0: A More Fair, Just, and Equitable World, for the Long-Term Survival of Mankind
  Governance and economics are the underpinnings of every family, neighbourhood, Town, City, Province or Territory, Country, and our World. As our world has become increasingly complex, and wonderfully nuanced over the past 50 to 100 years, the backbone of our g…
  preprints 2022 置信度 0.74
• An AI-guided signature reveals the nature of the shared proximal pathways of host immune response in MIS-C and Kawasaki disease
  A significant surge in cases of multisystem inflammatory syndrome in children (MIS-C, also called Pediatric Inflammatory Multisystem Syndrome - PIMS) has been observed amidst the COVID-19 pandemic. MIS-C shares many clinical features with Kawasaki disease (KD)…
  preprints 2021 置信度 0.74
• A New World Post COVID-19: Lessons for Business, the Finance Industry and Policy Makers
  Pandemics are disruptive events that have profound consequences for society and the economy. This volume aims to present an analysis of the economic impact of COVID-19 and its likely consequences for our future. This is achieved by drawing from the expertise o…
  preprints 2020 置信度 0.74
• Outlining the Challenges of COVID-19 Pandemic on Africa’s Maritime Industry: the Case of Marine and Seafaring Professionals
  Abstract Despite the ‘Key Worker’ status accorded seafarers in moments of demonstrable selflessness -ensuring, adequate supply of food, medicines, consumables like personal protective equipment (PPEs), and energy - there is a lack of genuine interest in their …
  preprints 2021 置信度 0.74
• Transitory Schwann Cell Precursor and hybrid states underpin melanoma therapy resistance and metastasis
  Melanoma plasticity, driven by phenotype state switching, underlies clinically relevant traits such as metastasis and therapy resistance. As melanoma progression is thought to recapitulate aspects of neural crest cell (NCC) development, understanding embryonic…
  preprints 2022 置信度 0.74
• TauchiGPT_V2: An Offline Agent-based Opensource AI Tool designed to Assist in Academic Research
  Recent progress in artificial intelligence, particularly deep learning, has ushered in a new era of autonomously generated content spanning text, audio, and visuals. This means Large Language Models (LLMs) such as ChatGPT, Llama2, Claude, and PaLM 2 are now de…
  crossref Ahmed Farooq, Jari Kangas, Mounia Ziat, Roope Raisamo 2024-01-21T00:46:29Z 置信度 0.70
• AI Inside the Classroom: A Modern Approach to Teaching AI Skills with Azure and Multi-Agent Concepts
  crossref M. Benkus, L. Masnec, Z. Stapić 2026-07-08T19:41:48Z 置信度 0.70
• AI Multi-Agent Workflows in R
  This workshop covers the principles and practice of building multi-agent LLM workflows in R using the mini007 package. Participants will learn agent creation, state management, LeadAgent-based task decomposition, and best practices for reproducible, research-r…
  crossref Fodil Ihaddaden 2026-08-10T14:57:07Z 置信度 0.70
• AUTONOMOUS MULTI-AGENT AI SYSTEMS FOR SALES AUTOMATION IN THE U.S. INSURANCE INDUSTRY
  crossref Vadym Shashkov 2026-08-10T12:07:11Z 置信度 0.70
• An Agentic AI-based Multi-Agent Framework for Recommender Systems
  Agentic AI describes the use of LLMs in novel AI agents that can answer questions or collaborate to achieve goals. These LLM agents can be used to build a novel generation of recommender systems. However, little is known about the LLM agents or their relations…
  crossref Ivens Da Silva Portugal, Paulo Alencar, Donald Cowan 2025-01-16T13:31:23Z 置信度 0.70
• Integrating Multi-Agent Systems in AI: A Framework Inspired by Physiology for Complex System Design
  Abstract This study explores the integration of artificial intelligence (AI) through a Multi-Agent System (MAS), utilizing autonomous networks to implement a novel framework demonstrated in a navigation system for the visually impaired. It capitalizes on MAS's…
  preprints Ching Han Chen, Ming Fang Shiu 2024 置信度 0.74
• Analysis of Online Agent Accounting Platform under Big Data AI Environment
  This paper aims to provide a comprehensive overview of the current status and future prospects of the agent bookkeeping service industry in China, focusing on the online agent bookkeeping platform developed by Nanjing Cloud Accounting Network Technology Co., L…
  crossref Zhifeng Yuan 2023-09-21T13:03:45Z 置信度 0.70
• AI-Driven Personalized Healthcare: Leveraging Multimodal Data for Precision Medicine
  The integration of artificial intelligence (AI) into personalized healthcare is transforming medical practice by enabling precise, individualized treatments through multimodal data fusion. This paper explores how AI can combine diverse data sources-including g…
  crossref Rui Lin 2025-05-05T17:52:01Z 置信度 0.70
• Generative AI and Retrieval-Augmented Generation (RAG) in an Agent-Based Simulation Framework for Urban Planning
  Urban planning is a multifaceted discipline that requires balancing economic growth, environmental sustainability and community needs. Traditional approaches often rely on static data and manual analyses, which can be time-consuming and less responsive to real…
  crossref 2024-10-29T10:57:13Z 置信度 0.70
• Fluency is the Key: AI Agent Language Dynamics on Customer Satisfaction and Transfer Requests
  &lt;div&gt; Hybrid systems, where customers begin interactions with AI agents and can later transfer to human agents, are increasingly common in digital customer care. Despite advancements in AI agent design, challenges remain in addressing customer reluctance…
  crossref Katsiaryna Siamionava, Reihane Boghrati, Jianlei Zhang, Tian Lu 2024-08-13T15:11:27Z 置信度 0.70
• CCC--Uno AI agent auxiliary system
  In this paper, we explore the design and implementation of a UNO game AI Agent based on the Mini-Max algorithm, and we named it "CardCraft Champ". UNO, as a popular card game, is filled with strategies and uncertainty, making it challenging to design an AI Age…
  crossref Chi Zhang, Zhengxiao Chen 2024-07-05T02:14:41Z 置信度 0.70
• Enabling understanding of artificial intelligence (AI) agent wargaming decisions through visualizations
  The process to develop options for military planning course of action (COA) development and analysis relies on human subject matter expertise. Analyzing COAs requires examining several factors and understanding complex interactions and dependencies associated …
  crossref Christina Rinaudo, William Leonard, Jaylen Hopson, Christopher Morey 等 2024-04-17T18:57:37Z 置信度 0.70