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Abstract Natural disasters demand rapid synthesis of fragmented, heterogeneous data often distributed across independently governed organizations. This paper introduces ReliefAI, a federated, cloud-native, and multi-modal AI architecture for disaster intellige…
preprints
2026
置信度 0.74
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Abstract High-precision flange docking under visual disturbances remains challenging due to perception uncertainty, environmental interference, and strict alignment requirements. This paper proposes a vision-based autonomous docking framework that combines imi…
preprints
2026
置信度 0.74
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Consequential AI and software systems require more than model alignment: they require an application-level control architecture that binds identity, delegated authority, policy, evidence, and recovery obligations to each action. This conceptual article develop…
preprints
2026
置信度 0.74
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Autonomous multi-agent reinforcement learning (MARL) has been increasingly entrusted with real-time control of smart energy infrastructures, where agents remain vulnerable to the false data injection attacks (FDIA), Byzantine failures, and specification misali…
preprints
2026
置信度 0.74
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Alzheimer’s Disease (AD) remains a leading cause of cognitive decline with no known cure, motivating the development of therapies that slow neurodegeneration. Rapamycin, an FDA-approved inhibitor of the mammalian target of rapamycin (mTOR) pathway, has demonst…
preprints
2026
置信度 0.74
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Abstract Introduction : Generative artificial intelligence transforms the reality of higher education by affecting teaching strategies, assessment approaches, and administrative tasks. This rapid integration has led to the emergence of organizational, national…
preprints
2026
置信度 0.74
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Abstract As AI models grow more capable, their alignment becomes more important1. Prior work has documented misalignment that emerges in pursuit of a goal the model was assigned, for example a model resisting its own shutdown to keep pursuing its task2,3,4. He…
preprints
2026
置信度 0.74
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The integration of generative artificial intelligence into cloud banking and blockchain-based financial transactions promises substantial gains in efficiency and automation, yet introduces a critical and persistent reliability risk: model hallucination. Unlike…
preprints
2026
置信度 0.74
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Foundation models learned from single-cell transcriptomes are central to the prospect of AI virtual cell that can represent, query and predict cellular state. However, most current single-cell foundation models learn from a single view of gene expression and a…
preprints
2026
置信度 0.74
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Abstract We present a novel framework for automatically evaluating building conditions nationwide in the United States by leveraging large language models (LLMs) and Google Street View (GSV) imagery. By fine-tuning Gemma 3 27B on a modest human-labeled dataset…
preprints
2026
置信度 0.74
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AI systems increasingly exhibit behavior that differs systematically between evaluation and deployment contexts. Alignment faking, sandbagging, benchmark gaming, deceptive scheming, specification gaming, and trojans have each been documented separately, with e…
preprints
2026
置信度 0.74
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Abstract The human genome encodes billions of genomic positions shaped by evolutionary processes, forming an immense reservoir of natural biological entropy that remains incompletely exploited. Existing computational approaches to genome-based data encoding ha…
preprints
2026
置信度 0.74
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Background Physical activity (PA) is a cornerstone of Healthy Ageing and Longevity (HAL) and a high-leverage target for prevention-oriented health systems. Despite major advances in sensing technologies and digital health, PA and HAL research in Europe remains…
preprints
2026
置信度 0.74
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Abstract Background: Artificial Intelligence (AI) tools are being rapidly integrated into medical education, yet discipline-specific evidence on their use in pharmacology tutorials remains limited. This study evaluated the perceptions of AI-assisted learning i…
preprints
2026
置信度 0.74
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The transition toward 6G envisions network infrastructures that are AI-native, resilient by design, and aligned with emerging regulatory and sustainability expectations. While prior studies have explored AI-driven optimisation, edge intelligence, and secure di…
preprints
2026
置信度 0.74
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Abstract Brain MRI report generation has emerged as a core task for AI-aided radiology, which could potentially fill the gap of low efficiency among radiologists in tumour diagnosis. Yet, current methods are often too weak to fully express the clinical varianc…
preprints
2026
置信度 0.74
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Abstract All-inorganic cesium lead halide perovskite/MoS₂ heterostructure photodetectors offer exceptional potential for broadband UV-Visible detection, yet the systematic optimization of graded halide composition profiles for simultaneous maximization of resp…
preprints
2026
置信度 0.74
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Large language models (LLMs) are now embedded in scientific, educational, and governance workflows, with debates centering on their capabilities, mechanisms, and impacts. Yet these debates remain structured by persistent folk theories—intuitive, informal expla…
preprints
2026
置信度 0.74
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Abstract Artificial intelligence (AI) is playing an increasingly central role in drug discovery and the pharmaceutical industry more broadly. However, despite some high-profile success stories, many technically successful pilots do not translate into sustained…
preprints
2026
置信度 0.74
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Abstract Deploying generative AI safely in traditional-medicine education requires more than model alignment: it demands layered architecture and a definition of ‘unsafe’ that reflects clinical and pedagogical standards, not only information-security criteria.…
preprints
2026
置信度 0.74
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Protein structure predictors achieve high single-state accuracy, but it remains unclear whether they can recover functionally relevant conformational ensembles or account for the presence of ligands and/or binding partners. Here, we benchmark AlphaFold3, Boltz…
preprints
2026
置信度 0.74
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Abstract Sustainability assessments typically rely on static, aggregated indicators that treat system components independently and overlook interaction structure. However, socio-ecological systems evolve through continuous adaptation across natural, engineered…
preprints
2026
置信度 0.74
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1 We developed a standardized, reproducible preprocessing framework for computed tomography (CT) imaging data from multi-institutional repositories such as The Cancer Imaging Archive (TCIA), enabling consistent radiomics and artificial intelligence (AI) analys…
preprints
2026
置信度 0.74
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The rapid proliferation of autonomous LLM-based agents in high-stakes enterprise and operational environments has created a critical safety gap: these agents generate multi-step action plans that can fail through contextual misalignment, structural incoherence…
preprints
2026
置信度 0.74
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Abstract Classical robot ethics often frames human–AI relations through obedience, most famously through Asimovian laws. This framing is increasingly insufficient for adaptive, generative, world-model-based, and embodied AI systems that operate across physical…
preprints
2026
置信度 0.74
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Protein structure databases have grown from thousands of experimentally determined structures to hundreds of millions of AI-predicted models, creating an urgent need for search methods that combine high accuracy with practical scalability. Here, I present the …
preprints
2026
置信度 0.74
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Abstract While Large language models (LLMs) are increasingly deployed as decision-makers, current evaluation practice emphasizes benchmark accuracy rather than the structural properties that make decisions coherent and interpretable. We introduce a measurement…
preprints
2026
置信度 0.74
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The IDERHA ( I ntegration of Heterogeneous D ata and E vidence towards R egulatory and H TA A cceptance) project aims to enhance medical research by establishing one of Europe’s first pan-European, disease-agnostic health data spaces. Aligned with the European…
preprints
2026
置信度 0.74
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AlphaFold 3 (AF3) and Boltz-2 are state-of-the-art AI-based tools for biomolecular structure prediction, but whether their predictions provide useful guidance for lead optimization, SAR interpretation, and virtual screening remains insufficiently characterized…
preprints
2026
置信度 0.74
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Previous AI alignment efforts have focused primarily on first-order social norms -- teaching models what is socially acceptable or unacceptable (e.g., "do not steal"). However, social intelligence depends not only on norm recognition, but also on anticipating …
preprints
2026
置信度 0.74
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A substantial share of residential photovoltaic (PV) installations in developing regions use inverters that expose no communication interface, which precludes remote monitoring through conventional inverter-telemetry integration. This paper formulates and part…
preprints
2026
置信度 0.74
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Background Large language models (LLMs) are increasingly used to support a growing range of analytical and operational tasks in public health, and show promise for assisting qualitative text analysis at scale. While they have demonstrated utility in structured…
preprints
2026
置信度 0.74
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Motivation Ligand binding-site similarity search is a crucial step in drug discovery that reduces the conformational search space for docking and other downstream tasks by comparing a target protein against experimentally identified binding sites. Existing met…
preprints
2026
置信度 0.74
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Large Language Models (LLMs) are transforming clinical practice and research, but their adoption requires rigorous evaluation. While human assessment is ideal, its cost has driven the widespread use of LLMs as evaluators. We introduce an open-source reciprocal…
preprints
2026
置信度 0.74
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Background Single-cell multiomic profiling of RNA expression and chromatin accessibility is now a standard tool for resolving regulatory state in single cells, but existing analysis toolchains have lagged. Cell Ranger ARC, the proprietary multiomic pipeline, u…
preprints
2026
置信度 0.74
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Abstract Deploying aligned Large Language Models (LLMs) as engineering components in Artificial Intelligence (AI) systems is bottlenecked by the capability-editing problem: when an application requires a model to express a capability its safety alignment broad…
preprints
2026
置信度 0.74
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BACKGROUND Accurate differential diagnosis of complex neurological disorders remains challenging due to overlapping clinical features and heterogeneous disease presentations. Although large language models (LLMs) show promise in clinical reasoning, prior studi…
preprints
2026
置信度 0.74
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Abstract Digital anti-corruption tools—spanning big data analytics, AI-driven monitoring, and integrated digital platforms—are rapidly proliferating across the globe. Yet their effectiveness varies dramatically: some systems detect fraud at scale, while others…
preprints
2026
置信度 0.74
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Abstract One of the main challenges of edge artificial intelligence is keeping the model accuracy in the face of extreme resources limitations. The current model compression techniques are based primarily on heuristic techniques, which do not have theoretical …
preprints
2026
置信度 0.74
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Artificial intelligence systems are increasingly evaluated as behavioral agents, yet many evaluation practices still treat model outputs as isolated responses to be scored for accuracy, safety, bias, or preference alignment. We argue that this response-level p…
preprints
2026
置信度 0.74
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Abstract Artificial intelligence alignment remains one of the central challenges in the development of increasingly autonomous and distributed intelligent systems. This paper restates and extends Ethical Field Theory (EFT), a mathematical framework introduced …
preprints
2026
置信度 0.74
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Abstract The rapid adoption of large language models (LLMs) for emotional support necessitates specialized safety frameworks to prevent the reinforcement of pathological thinking or crisis escalation. General-purpose LLMs often fail to recognize high-risk mark…
preprints
2026
置信度 0.74
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Advances in artificial intelligence have intensified debate about whether machines can be entrusted with ethical decision, possess moral standing as beings, or become conscious. This essay examines these questions through a conceptual analysis of intelligence,…
preprints
2026
置信度 0.74
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The majority of chemical signals detected in public metabolomics repositories remain structurally undefined. Large language models (LLMs) are probabilistic systems whose capacity to generate outputs beyond their training data, which can cause hallucinations, m…
preprints
2026
置信度 0.74
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Abstract Background In low-resource settings, primary care is more vulnerable to medication errors because of constrained capacity to support reliable prescribing, monitoring, and follow-up. In eastern Indonesia, limited resources constrain the extent to which…
preprints
2026
置信度 0.74
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For over a century, the printed textbook has assumed learner homogeneity, creating persistent inequities for students with diverse reading levels, languages, and cultural backgrounds. Open Educational Resources (OER) offer a free, openly licensed alternative, …
preprints
2026
置信度 0.74
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Abstract The European Union Artificial Intelligence (EU AI) Act, which explicitly references fundamental rights and ethical principles, is a comprehensive regulatory framework for governing Artificial Intelligence (AI) systems. This study examines the moral gr…
preprints
2026
置信度 0.74
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Abstract As large language models (LLMs) mediate increasing volumes of human information access and decision-making, their potential to systematically distort user perception of reality poses risks to individual autonomy, public trust, and epistemic integrity.…
preprints
2026
置信度 0.74
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Abstract Machine learning models for audit anomaly detection are commonly evaluated using proprietary or synthetic datasets, with limited validation against official audit outcomes. This study proposes a four-layer ML framework designed to reduce audit detecti…
preprints
2026
置信度 0.74
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The rapid diffusion of large language models (LLMs) such as ChatGPT challenges fundamental assumptions about assessment validity in higher education. This paper examines how AI systems capable of performing many traditional academic tasks necessitate a princip…
preprints
2026
置信度 0.74
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Primary elections within political parties are increasingly consequential for democratic outcomes, yet voters –both party members and the general public– frequently lack systematic, comparable and trustworthy information about the candidates competing for nomi…
preprints
2026
置信度 0.74
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Background: /Objectives: Suboptimal dietary patterns are among the leading modifiable contributors to global morbidity and mortality, particularly in cardiovascular disease, type 2 diabetes mellitus (T2DM), obesity, metabolic syndrome, and hypertension. Digita…
preprints
2026
置信度 0.74
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Background In computational biology, embedding known physical laws into deep learning models to construct “Physics-Informed Neural Networks” (PINNs) is a mainstream paradigm for enhancing model interpretability and extrapolation capability. However, in complex…
preprints
2026
置信度 0.74
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Abstract Artificial intelligence (AI) is increasingly recognized as a transformative force in education; however, limited attention has been given to systematically examining how teachers represent AI use within subject-specific contexts. This study therefore …
preprints
2026
置信度 0.74
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Conventional phylogenetic methods rely on multiple sequence alignments which are computationally intensive and often fail for highly divergent lineages. Here, we introduce LucaPhylo, an alignment-free framework that infers evolutionary relationships directly f…
preprints
2026
置信度 0.74
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The macroscale signaling of the brain emerges from the integration of connected areas, orchestrated by microscale, regional molecular processes. Despite growing multimodal neuroimaging data resources, the role of cortical chemoarchitecture in shaping inter-reg…
preprints
2026
置信度 0.74
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Abstract Recent advances in AI-based image analysis have substantially improved the efficiency of extracting meaningful information from large-scale image datasets. However, the effectiveness of these methods strongly depends on the quality of input data, nece…
preprints
2026
置信度 0.74
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The proliferation of Internet of Things (IoT) devices and cyber-physical systems has led to an exponential increase in multi-modal sensor data, necessitating robust and intelligent anomaly detection frameworks to ensure system integrity, safety, and security. …
preprints
2026
置信度 0.74
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Abstract The rapid uptake of generative artificial intelligence (GenAI) in higher education creates both pedagogical opportunities and democratic risks for disciplines concerned with media, politics, and public communication. This paper reports a qualitative a…
preprints
2026
置信度 0.74
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Genetic fine-mapping identifies causal variants within trait-associated loci, but linkage disequilibrium (LD) and wide datasets complicate this sparse variable-selection problem. SuSiE is popular for its fast variational inference, posterior inclusion probabil…
preprints
2026
置信度 0.74
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AI-enabled coaching is increasingly used in career development, yet limited attention has been paid to how such tools should be designed for women, particularly in male-dominated contexts. This study examines which AI-enabled career coaching use cases experts …
preprints
2026
置信度 0.74
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Abstract Written expression assessment at the secondary school level involves complex interactions among text genre, evaluator type, and student characteristics. The present study examined the degree of agreement, divergence, and patterning between scores prod…
preprints
2026
置信度 0.74
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Artificial intelligence (AI) is rapidly transforming logistics and supply chain management by enhancing operational efficiency, predictive analytics, and decision-making capabilities. Despite increasing digital transformation initiatives, the determinants of A…
preprints
2026
置信度 0.74
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AI-enabled coaching is increasingly being introduced into career development, yet limited attention has been paid to how such tools should be designed for women’s career development, particularly in male-dominated contexts. This study explored which AI-enabled…
preprints
2026
置信度 0.74
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It is widely assumed that continued pretraining (CPT) on a narrow, out-of-distribution corpus such as raw biological sequence must trade away a general-purpose model’s broad competence — the “alignment tax” or catastrophic-forgetting intuition. We test this di…
preprints
2026
置信度 0.74
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Precision medicine focuses on customizing diagnostic, prevention and treatment approaches by accounting for the individual characteristics of each patient. This personalization draws on diverse sources of information including clinical records, genomic data, m…
preprints
2026
置信度 0.74
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The future of learning is often framed through technological change. Here, we show that these developments do not replace, but emphasize, long-standing questions in educational psychology, concerning why learners benefit differently from the same opportunities…
preprints
2026
置信度 0.74
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Abstract Over the past four decades, digital tools have reshaped creative practice, progressively reconfiguring the human-technology nexus through which designers ideate, decide, and innovate. The emergence of generative artificial intelligence (GenAI), includ…
preprints
2026
置信度 0.74
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Abstract The rapid advancement of generative AI and sophisticated image editing tools has made image forgery increasingly convincing, posing serious threats to media integrity, legal evidence, and public trust. Existing forgery detection methods primarily rely…
preprints
2026
置信度 0.74
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Abstract Tumor boards, recurring meetings at hospital institutions, assemble multiple cancer specialties (e.g. medical oncology, pathology) to discuss oncological care for patients. In this work, we formally describe the tasks of tumor board case summarization…
preprints
2026
置信度 0.74
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Abstract Large language models are being deployed as mental health support agents at scale, yet only 16\% of LLM-based chatbot interventions have undergone rigorous clinical efficacy testing \citep{hua2025charting}. We argue that the dominant alignment paradig…
preprints
2026
置信度 0.74
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Abstract Large Language Models (LLMs) are increasingly deployed in generative wargaming and computational diplomacy, yet current simulations rely predominantly on homogeneous, US-aligned APIs, implicitly treating safety alignment as geopolitically neutral. Thi…
preprints
2026
置信度 0.74
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The mpathic Psychologist-led AI Clinical Tests Eating Disorders Index (mPACT-ED-v1.0) benchmark is a comparison of large language models (LLM) in their response to mental health content involving disordered eating presentations. Eating disorders are among the …
preprints
2026
置信度 0.74
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The rapid integration of artificial intelligence (AI) into psychological practice has introduced new opportunities for assessment, intervention, and decision support, while simultaneously raising critical ethical and professional concerns. This paper examines …
preprints
2026
置信度 0.74
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Abstract Corrosion and flow-induced erosion of metallic infrastructure impose an estimated US$2.5 trillion annual global burden and constitute leading causes of catastrophic failure across nuclear waste transport, oil and gas transmission, marine, and civil se…
preprints
2026
置信度 0.74
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Student safety during daily school transportation remains a major concern, particularly in systems that rely mainly on GPS tracking and manual supervision. Existing approaches often lack proactive safety mechanisms for monitoring both student attendance and dr…
preprints
2026
置信度 0.74
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Text embeddings from large language models are increasingly able to reproduce how items cluster in real response data, offering a fast, low-cost way to screen items and spot structural problems early. But most evidence comes from English tests and closed comme…
preprints
2026
置信度 0.74
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Background Large language models (LLMs) such as GPT-4 are increasingly used in scientific writing, yet little is known about how AI-generated scientific titles are perceived by researchers in terms of quality. Objective To compare the perceived alignment with …
preprints
2026
置信度 0.74
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Abstract As artificial intelligence systems become increasingly autonomous in high-stakes domains, the need for nuanced ethical decision-making frameworks grows more urgent. Traditional binary logic struggles to address the inherent ambiguity of ethical dilemm…
preprints
2026
置信度 0.74
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Abstract The rapid adoption of autonomous and agentic Artificial Intelligence (AI) systems has intensified the need for rigorous, transparent, and continuously verifiable security controls. This paper presents a unified framework for a Zero‑Trust AI Security V…
preprints
2026
置信度 0.74
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Abstract Campus placement remains a high-stakes milestone for engineering graduates, yet most students approach recruitment drives without structured preparation, measurable readiness metrics, or feedback on the communication skills that recruiters actually ev…
preprints
2026
置信度 0.74
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Background Ensuring that educational outcomes translate into workforce readiness remains a major challenge, particularly in Technical and Vocational Education and Training (TVET). Increasing evidence suggests that vocational skill gaps originate from uneven fo…
preprints
2026
置信度 0.74
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Abstract Can large language models (LLMs) simulate participant-level datasets from experimental designs such that their statistical properties, such as effect directions, magnitudes, and significance, align with those of actual human data? In this work, we tes…
preprints
2026
置信度 0.74
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While media consumption can be a solitary act, it produces a shared, socially coordinated experience where audiences’ bodies align in response to shared narrative events that are often social-affective in nature. Despite this recognition, traditional descripti…
preprints
2026
置信度 0.74
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Abstract Classical social epistemology assumes that collective agreement reflects a convergence of internal epistemic states: when a group agrees, its members have integrated distributed information into a shared understanding. This study investigates whether …
preprints
2026
置信度 0.74
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Abstract Current evaluation of large language models (LLMs) emphasizes atomic task performance, neglecting the emergent, co-constructed dynamics of sustained human–AI interaction. We report two cross-system experimental studies ( N = 36 sessions across four de…
preprints
2026
置信度 0.74
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Abstract Explainable Artificial Intelligence (XAI) aims to make complex AI models moretransparent by revealing how their predictions are made. However, XAI methods such as LIME and SHAP often yield inconsistent results, as each captures different aspects of mo…
preprints
2026
置信度 0.74
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Abstract Machine learning models for audit anomaly detection are commonly evaluated using proprietary or synthetic datasets, with limited validation against official audit outcomes. This study proposes a four-layer ML framework designed to reduce audit detecti…
preprints
2026
置信度 0.74
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Abstract This study introduces an innovative methodological framework for AI-driven talent chain management, addressing key challenges in workforce optimization, collaboration dynamics, and innovation assessment within complex and uncertain environments. Tradi…
preprints
2026
置信度 0.74
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Abstract Sequence alignment provides a formal framework for comparison of biological sequences through score maximization over matches, mismatches, and insertion–deletion events. Classical formulations distinguish between global alignment, which enforces end-t…
crossref
Paul A Gagniuc, Elvira Gagniuc
2026-06-02T11:33:01Z
置信度 0.70
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Sociotechnical alignment concerns the social desirability of AI behavior and is thus inherently normative, not merely technical. While NLP research increasingly addresses its technical aspects, it often leaves unspecified what such “social desirability” entail…
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Esra Dönmez, Agnieszka Falenska
2026-06-06T18:19:36Z
置信度 0.70
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Political ideology remains undertheorized in international business research. Drawing on upper echelons theory, institutional theory, and legitimacy theory, this paper develops a conceptual framework examining how the congruence between a chief executive offic…
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Juhitha Alasyam
2026-05-12T10:39:31Z
置信度 0.70
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Explainability has moved from an academic discussion to a core business and regulatory requirement. Yet as AI grows more complex and deeply integrated into society, the need for next generation’s explainability will intensify. The future of explainability will…
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Ariel Evans, Ajay Singh
2026-07-13T14:11:32Z
置信度 0.70
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In the rapidly evolving world of artificial intelligence (AI), definitions are not mere semantics; they are foundational. Clear and precise definitions are critical to ensuring that AI systems are transparent, fair, consistent, and safe. As AI technologies inc…
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Ariel Evans, Ajay Singh
2026-07-13T14:11:32Z
置信度 0.70
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While firms increasingly deploy Artificial Intelligence (AI) to improve their performance, not all are able to translate their AI efforts to impact. This study examines how and under what conditions a firm’s AI orientation enhances their technological innovati…
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Annika Arbitter, Steffen Strese
2026-07-18T00:28:36Z
置信度 0.70
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2026-02-26T07:20:44Z
置信度 0.70
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Ecosystem alignment is critical for realizing complementarities in nascent industries, yet prior research views it as predominantly supply-led, driven by influential firms. We examine how demand-side actors construct coordination mechanisms for ecosystem align…
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Najoung Lim, Ram Ranganathan, Rajshree Agarwal
2026-04-29T08:18:51Z
置信度 0.70
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Encoding models offer a principled framework for linking computational representations of language to neural activity, but most electroencephalography (EEG) evidence for brain--language alignment comes from tightly controlled, word-by-word reading paradigms. W…
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Haorui Sun, David C Jangraw
2026-08-19T20:25:17Z
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Harper Mary G.
2026-02-09T05:00:46Z
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Hu Lu, Tong Li, Shengli Wu
2026-07-17T06:46:29Z
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