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• Single-cell spatial transcriptomics reveals sex-dependent gene expression and intercellular signalling in mouse adrenal cortex.
  Sexual dimorphism profoundly influences adrenal physiology and disease susceptibility, yet its spatial molecular basis remains poorly understood. The female-predominant X-zone, a transient cortical structure recognized for nearly a century, has lacked comprehe…
  pubmed Blatkiewicz M, Hryhorowicz S, Szyszka M, Suszynska-Zajczyk J 等 2026 Jul 14 置信度 0.82
• Slow-SPEED: protocol for three randomised trials of remotely delivered exercise to prevent Parkinson's disease.
  We describe the design of the first non-pharmacological Parkinson's disease prevention trials worldwide: the randomised 'Slow-SPEED' trials. Three trials examine the feasibility and preliminary efficacy of a gamified, remotely administered exercise interventio…
  pubmed Oosterhof TH, Mitchell E, Ascherio A, Aslibekyan S 等 2026 Jul 14 置信度 0.82
• Frontline Health Workers' Perspectives of the World Health Organization Skin Neglected Tropical Diseases App in Kenya: Qualitative Study on AI-Embedded mHealth Implementation.
  Skin neglected tropical diseases (NTDs) pose significant diagnostic and management challenges in resource-limited settings due to constrained dermatological expertise, frontline health worker (FHW) training, and limited access to diagnostic resources. Mobile h…
  pubmed Quilter EEV, Nyangacha R, Kinyeru E, Fuster Casanovas A 等 2026 Jul 14 置信度 0.82
• The Hemodynamic Performance of Two Mechanical Cardiopulmonary Resuscitation Devices.
  Mechanical cardiopulmonary resuscitation (mCPR) devices are increasingly used during percutaneous coronary intervention (PCI) in intracardiac arrest patients. However, the optimal invasive hemodynamic parameter to guide mCPR remains unclear. This study compare…
  pubmed Sajjad U, Simpson R, Movio G, Cook C 等 2026 Jul 14 置信度 0.82
• Instrument-Software Synergy in Proteomics: Systematic Evaluation across Mass Spectrometry Platforms, Search Engines, and Rescoring Methods.
  Mass spectrometry-based proteomics has advanced through parallel improvements in instrumentation (mass spectrometers) and software (data analysis), yet whether these improvements interact synergistically or provide diminishing returns remains unclear. Here, we…
  pubmed Heyndrickx S, Bouwmeester R, Declercq A, Devreese R 等 2026 Aug 7 置信度 0.82
• Efficacy evaluation of novel targeted drugs in patients with human epidermal growth factor receptor 2-positive breast cancer: A meta-analysis based on multiple sets of clinical data.
  ObjectiveTo evaluate the efficacy and safety of novel targeted drugs in patients with human epidermal growth factor receptor 2-positive breast cancer and their impact on clinical outcomes, including overall survival and progression-free survival.MethodsThis sy…
  pubmed Lan Y, Wang R, Liu S 2026 Jul 置信度 0.82
• Planning and implementation of a community-wide tuberculosis screening intervention: a case study from Naujaat, Nunavut, Canada.
  In Nunavut, public health management of tuberculosis (TB) remains a challenge due to social and economic inequities, geographic isolation, TB-related stigma, and distrust in healthcare linked to a history of colonialism. A TB outbreak was declared in Naujaat, …
  pubmed Xie XT, Batac ALR, Wills O, Kulleperuma K 等 2026 Dec 31 置信度 0.82
• Global trends and insights in cervical cancer research: a bibliometric analysis from 2000 to 2024.
  Cervical cancer is the fourth most common malignant disease in women worldwide. Although the promotion and use of human papillomavirus (HPV) vaccinations have, to some extent, reduced the incidence of cervical cancer, problems persist, particularly in low- and…
  pubmed Cheng J, Li M, Li C, Ding J 等 2026 Jul 1 置信度 0.82
• Health and Socioeconomic Factors in School Readiness and Achievement Among Children Born Very Preterm.
  Preterm birth is a leading cause of atypical brain development and cognitive impairment; however, there are sparse data on its association with statutory educational assessments.
  pubmed Haider S, Tsanas A, Batty GD, Reynolds RM 等 2026 Jul 1 置信度 0.82
• HighDB: a structure-annotated cyclic peptide database for comparative analysis, template retrieval, and design-oriented applications.
  Cyclic peptides are increasingly explored as modulators of difficult-to-drug targets and protein-protein interactions, yet structure-centered resources with standardized, computable annotations remain limited. Here we present HighDB, a curated database of expe…
  pubmed Xu Y, Zhu N, Shang T, Yao S 等 2026 Jul 14 置信度 0.82
• Exploring NiCl(2), PdCl(2) and PtCl(2) as a catalyst for [3 + 2] cycloaddition in Kopsane alkaloid synthesis by density functional theory study.
  Kopsane alkaloids possess a complex heptacyclic scaffold and exhibit significant biological activities, including cholinergic, anti-inflammatory, and anti-cancer effects. While we previously reported PtCl 2 -catalyzed [3 + 2] cycloaddition for th…
  pubmed Yoon S, Nakliang P, Shaker B, Ye T 等 2026 Apr 置信度 0.82
• Siderophore-Porphyrin conjugates for bacteria-selective antimicrobial photodynamic therapy.
  Targeted delivery of photosensitizers represents a key strategy for improving the selectivity and efficacy of antimicrobial photodynamic therapy (aPDT). Herein, we describe the synthesis and biological evaluation of siderophore-conjugated photosensitizers desi…
  pubmed Oh J, Choi S, Yang W, Choi J 等 2026 Apr 置信度 0.82
• ALPK3 regulates cardiomyocyte apoptosis through the Notch1 signaling pathway.
  ALPK3, a gene associated with pediatric cardiomyopathy, plays a pivotal role in cardiac development, yet the regulatory mechanisms governing its involvement in cardiomyocyte apoptosis are still not well understood. Detect the expression changes of ALPK3 in emb…
  pubmed Yuan Y, Zheng C, Ye J, Zhou J 等 2026 Jul 14 置信度 0.82
• Automation Bias in Action: Eye Tracking of Humans Reading Screening Mammograms with and without AI Prompts.
  Background Incorrect artificial intelligence (AI) suggestions can lead to automation bias; however, their impact on medical image interpretation is underresearched. Purpose To assess how incorrect AI suggestions influence the diagnostic accuracy, read times, a…
  pubmed Taib AG, Partridge GJW, Phillips P, Maxwell-Armstrong C 等 2026 Jul 置信度 0.82
• Maximizing Nanoscale Disorder in Block Copolymers for Orientation-Independent SERS Platform Toward Non-Invasive Diagnostics.
  The development of high-performance optical molecular diagnostic platforms requires the precise engineering of light-matter interactions to ensure quantitative accuracy across diverse sensing environments. While high-density nanogap architectures based on bloc…
  pubmed Kim JM, Kim W, Kim W, Kim YH 等 2026 Jul 14 置信度 0.82
• APOE ε4 and Alzheimer's disease biomarkers in an American Indian community.
   Apolipoprotein E ( APOE ) ε4 's effect on Alzheimer's disease (AD) depends on ancestry and environmental risk factors. The APOE ε4 -AD link in American Indian (AI) populations appears attenuated, with current understanding largely informed by…
  pubmed Matheson MJ, Labounek R, Block AD, Strong C Jr 等 2026 Jul-Sep 置信度 0.82
• Characteristics of adverse events following immunization reporting systems: A scoping review.
  ObjectiveThis study aimed to identify characteristics of adverse events following immunization (AEFI) reporting systems and vaccine adverse events reporting systems (VAERS) including technical platforms, user groups, data elements, functional and non-functiona…
  pubmed Asadi H, Ayatollahi H, Zahraei SM, Eybpoosh S 2026 Jul-Sep 置信度 0.82
• Clinical Recommendations for Remote Robotic Assisted Surgery From the CRSA 2025 International Consensus Conference.
  Implementation of remote robotic-assisted surgery (rRAS) has the potential to significantly improve access to high-quality surgical care for patients worldwide. Advances in robotic systems and telecommunications now enable highly reliable, low latency, and cyb…
  pubmed Fong Y, Raptis DA, Kavoussi L, Wren SM 等 2026 Aug 置信度 0.82
• Application of selective outflow control technique-assisted laparoscopic hepatectomy for hepatocellular carcinoma in the right posterior superior area: a case series study (with video).
  Laparoscopic liver resection (LLR) for hepatocellular carcinoma (HCC) involving the right posterosuperior area (segments 7 and 8) remains technically demanding because of the deep anatomical location of these lesions and their close relationship to the right h…
  pubmed Xie Q, Zhang B, Tan YC, Koh B 等 2026 Aug 置信度 0.82
• Feasibility of using artificial intelligence models to identify the obturator nerve in laparoscopic selective lateral pelvic lymph node dissection.
  Protecting the obturator nerve (ON) is crucial during selective lateral pelvic lymph node dissection (SLPLND). This study evaluated the feasibility of an artificial intelligence (AI)-assisted system for real-time intraoperative identification of the ON in lapa…
  pubmed Zeng H, Wang X, Pan H, Zhu H 等 2026 Aug 置信度 0.82
• Elamipretide (SS-31) and Nicotinamide Mononucleotide (NMN) Combination Therapy Targets TREM2 to Mitigate Post-ischemic Brain Injury in Mice.
  Ischemic stroke is a severe cerebrovascular disorder characterized by a cascade of pathological processes, including neuroinflammation and apoptosis. These processes lead to high mortality rates and long-term disabilities, imposing substantial socioeconomic bu…
  pubmed Yang Q, Zhang Y, Liu P, Yan Z 等 2026 Jul 14 置信度 0.82
• Open dataset and deep learning model for intelligent diagnosis of neonatal respiratory distress syndrome and aspiration syndrome in newborns.
  Neonatal pulmonary diseases such as aspiration syndrome (AS) and respiratory distress syndrome (NRDS) require timely diagnosis, yet manual interpretation of neonatal X-rays is labor-intensive and subjective. To support AI-assisted diagnosis, we constructed the…
  pubmed Wu J, Xu Z, Yang R, Zhu B 等 2026 Jul 14 置信度 0.82
• Clinician perceptions of artificial intelligence in care: A cross-sectional survey.
  Artificial intelligence (AI) is increasingly being explored as a tool to enhance efficiency, access, and diagnostic accuracy in mental health care. However, the perspectives of clinicians, who are central to the delivery and oversight of care, on the use of AI…
  pubmed Stephenson C, Eadie J, Omrani M, Alavi N 2026 Jul 6 置信度 0.82
• Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease: An Individual Participant Data Meta-Analysis.
  Amyloid positron emission tomography (PET) is increasingly used in research and clinical settings to determine the etiology of cognitive decline and eligibility for amyloid-targeting therapies. To assist with amyloid PET evaluation and to guide clinical decisi…
  pubmed Blazhenets G, Soleimani-Meigooni DN, Chiotis K, Allen IE 等 2026 Jul 13 置信度 0.82
• Amplifier or substitute? A systematic review of generative AI's impact on higher-order cognitive skills among university students.
  As generative artificial intelligence (GenAI) becomes embedded in university learning environments, understanding its effects on students' higher-order cognitive development has become one of the most pressing questions in educational research.
  pubmed Alubthane FO 2026 置信度 0.82
• CO and NO(2) dynamics in a Brazilian tropical transition zone: the role of land use and road infrastructure.
  Land-use dynamics and road infrastructure are key anthropogenic drivers of air pollution in tropical landscapes undergoing rapid transformation. This study investigates how land cover and proximity to major roads influence carbon monoxide (CO) and nitrogen dio…
  pubmed Silva AGLE, Garcez MR, Brito LAT 2026 Jun 置信度 0.82
• Impact of preoperative smoking on outcomes of endoscopic transsphenoidal surgery for pituitary tumor.
  Cigarette smoking and nicotine dependence are prevalent in the general population and can negatively impact surgical outcomes. However, the effect of preoperative smoking status on the outcomes of endonasal transsphenoidal surgery (ETS) for pituitary adenomas …
  pubmed Wong CE, Kuo YC, Chen PW, Lee JS 等 2026 Jul 13 置信度 0.82
• Special collection on responsible forecasting in climatology and environmental sciences.
  Following a corresponding PICO session at the General Assembly of the European Geophysical Union 2024, we present in this Special Collection a number of papers that attempt responsible verified forecasts. The papers focus on approaches based on, or inspired by…
  pubmed Blesić S, Livina V, Ludescher J 2026 Jul 1 置信度 0.82
• Assessing the concordance between ChatGPT-4 and EAU guidelines indications in bladder cancer management: a real-world study.
  The integration of Artificial Intelligence (AI), particularly Large Language Models (LLMs) like ChatGPT, into healthcare is reshaping patient information-seeking behaviors. While prior studies have evaluated ChatGPT's performance across various urological doma…
  pubmed Lo Re M, Cadenar A, Pezzoli M, Mancon S 等 2026 Jun 置信度 0.82
• Ameliorative Effects of a Naphthoquinone Derivative With β-Amyloid Aggregation Inhibitory Activity on Cognitive Impairment and Metabolite Analysis of the Blood and Brains of Mice.
  Accumulation of amyloid-β (Aβ) plaques is an important cause of Alzheimer's disease (AD) pathogenesis. In this study, we evaluated Aβ aggregation inhibitory activity of synthesized naphthoquinone derivatives as well as improvement in cognitiv…
  pubmed Oh JM, Jeong WK, Son HJ, Kim SY 等 2026 Aug 置信度 0.82
• Artificial Intelligence Cannot Replace Peer Reviewers but May Help Editors Triage: A Comparative Analysis of a Large Language Model and Human Reviewer Recommendations at the American Journal of Sports Medicine.
  The peer review system faces increasing strain from rising manuscript volumes, reviewer fatigue, and well-documented interreviewer disagreement. Large language models (LLMs) have shown potential to support the peer review process, but their ability to replicat…
  pubmed Patel R, Shultz C, Ollivier M, Wascher DC 2026 Jul 12 置信度 0.82
• Knowledge, Attitudes and Practices of Pre-Pregnancy Risk Management Among Childbearing-Age Women With a Kidney Transplant: A Cross-Sectional Study.
  Some women of child-bearing age with a kidney transplant have a strong fertility desire, but they face a significantly higher risk of pregnancy than healthy women. Pre-pregnancy risk management can help patients achieve planned pregnancies and reduce the risk …
  pubmed Ma H, Lin W, Wu M, Wan J 等 2026 Jul 置信度 0.82
• Obesity and diabetes associated with dysregulation of mevalonate pathway markers and progression from pancreatic intraepithelial neoplasia to invasive pancreatic tumor.
  Cholesterol metabolic reprogramming plays a key role in pancreatic cancer progression by regulating the tumor immune microenvironment (TIME) and influencing responses to immunotherapy. Pancreatic intraepithelial neoplasia (PanIN) is the most common precursor l…
  pubmed Rezagholizadeh F, Rokn S, FakherBaheri M, Taherian Z 等 2026 Jul 11 置信度 0.82
• Implementation of an AI-driven hierarchical medical system for chronic disease management: ethical framework, resource optimization, and effectiveness evaluation.
  The aim of this study was to assess the integration pathways and ethical frameworks associated with the use of artificial intelligence (AI) within hierarchical medical systems for chronic disease management, and quantitatively assess its impact on healthcare r…
  pubmed Huang XM, Zhao JF, Zhang WY, Di YL 等 2026 Nov 1 置信度 0.82
• Beyond the algorithm: health technology assessment frameworks for AI in cardiology under the European Union Health Technology Assessment Regulation: a systematic review.
  Artificial intelligence (AI) is increasingly used in cardiovascular care to support diagnosis, monitoring and clinical decision-making. However, its dynamic and adaptive nature challenges conventional health technology assessment (HTA) frameworks, which are ty…
  pubmed Osoro L, Vasey B, McCulloch P, Broghammer F 等 2026 Jun 30 置信度 0.82
• Deep learning for cardiovascular disease: a comprehensive review of detection and risk forecasting.
  The biggest health threat to the global population is cardiovascular disease (CVD), which afflicts almost one-third of the global population and causes considerable monetary and social losses. Risk analysis should be performed in a timely and appropriate manne…
  pubmed Ganeshan N, Magesh G 2026 置信度 0.82
• Effect of RAS inhibitors on retinal microvasculature in DKD using AI-based ultra-wide-field images.
  Diabetic kidney disease (DKD) and diabetic retinopathy (DR) represent two major microvascular complications of diabetes mellitus (DM). Previous studies have suggested that renin-angiotensin system inhibitors (RASi) exert protective effects on both DKD and DR. …
  pubmed Liu Y, Zhao X, Wang H, Ma J 等 2026 置信度 0.82
• Exploring the landscape of artificial intelligence in dental and maxillofacial radiology: a bibliometric analysis of studies and trends.
  The integration of artificial intelligence (AI) in dental and maxillofacial radiology is revolutionizing diagnostic accuracy and clinical decision-making. This bibliometric analysis investigates the research landscape, emerging trends, and scholarly impact of …
  pubmed Amin Amiri M, Korsapati HR, Anil G, Mahapatro A 等 2026 Jul 置信度 0.82
• Dietary patterns and exploratory gut microbiota profiles associated with diabetic retinopathy and cognitive impairment in type 2 diabetes.
  Diabetic retinopathy (DR) and cognitive impairment are closely related complications of type 2 diabetes mellitus (T2DM). Although dietary patterns and gut microbiota have each been linked to these conditions, their combined associations with co-occurring DR an…
  pubmed Sheng Y, Chi H, Li C, Huai B 等 2026 Jul 10 置信度 0.82
• S100A4 promotes collective invasion of pancreatic ductal adenocarcinoma and its blockade suppresses metastasis.
  Most solid tumors invade peritumoral tissues as multicellular units while maintaining cell-cell interactions and epithelial characteristics, a process known as collective invasion. Our previous proteomic analysis revealed that S100-family proteins were upregul…
  pubmed Son DW, Lim YJ, Yu CW, Cha MJ 等 2026 Jul 10 置信度 0.82
• Digital health literacy among university students: a systematic review of global trends, determinants, measurement, and the literacy-to-intervention gap.
  University students interact with the complexities of public health knowledge in digital environments. Digital health literacy (DHL), in this regard, is crucial as an upstream skill for ensuring safe, inclusive, and knowledgeable health care engagement among u…
  pubmed Chandak A, Chandak P, Patil A, Varma R 2026 Jul 10 置信度 0.82
• Navigating sexual healthcare: a qualitative study on experiences, STI knowledge, and information sources among migrant men who have sex with men in the Netherlands.
  Migrant men who have sex with men (mMSM) may face barriers in accessing sexual healthcare and information, contributing to health disparities, as they are at increased risk of exposure to sexually transmitted infections (STIs), including HIV, hepatitis B, and …
  pubmed Moonen CPB, Hoebe CJPA, den Heijer CDJ, Buursma J 等 2026 Jul 10 置信度 0.82
• Evaluation of modafinil's neuroprotective effects in lipopolysaccharide-induced sepsis-associated encephalopathy: associations with GSK3β, inflammatory, oxidative stress, and apoptotic signaling.
  Sepsis is frequently accompanied by central nervous system involvement, leading to sepsis-associated encephalopathy characterized by neuroinflammation, microvascular dysfunction, and neuronal injury. Despite increasing recognition of its clinical impact, effec…
  pubmed Savran M, Hatip AY, Aşcı S, Oğuzoğlu AS 等 2026 Jul 11 置信度 0.82
• Charge energy-dependent interlock and failure behavior of CFRP/Al E-SPR joints.
  Automobile manufacturers are increasingly focusing on lightweight structures to improve fuel efficiency, with carbon fiber reinforced plastic (CFRP) and aluminum alloys widely applied. However, joining these dissimilar materials remains challenging due to diff…
  pubmed Kim M, Park M, Lee J, Park C 等 2026 Jul 10 置信度 0.82
• Two-year functional outcomes following moderate-to-severe tbi in patients on antithrombotics: Propensity-matched case-controlled study.
  Traumatic brain injury (TBI) is a major cause of morbidity in the United States. Elderly patients are more likely to have pre-trauma anticoagulation and antiplatelet therapy (ACAP), which theoretically increases morbidity risk in TBI. Currently, this interacti…
  pubmed Burwell JM, Huang J, Nasser L, Gonzalez B 等 2026 Oct 置信度 0.82
• Using Ecological Momentary Assessment, Geolocation Tracking, and Neuroimaging to Assess Effects of Tobacco Retail Exposure on Smoking Behavior: Protocol for the GeoSmoking Study.
  Cigarettes are a global public health concern, as cigarette smoking is the leading cause of death in the United States and throughout most high-income countries. Exposure to tobacco retail has been linked to adverse smoking outcomes, but research using natural…
  pubmed Cooper N, Muzekari B, Resnick A, Paul AM 等 2026 Jul 10 置信度 0.82
• Machine learning prediction of local control after Gamma Knife radiosurgery to post-resection cavities from brain metastases: a proof-of-concept study.
  Large symptomatic brain metastases require initial surgical resection. However, local control (LC) after Gamma Knife radiosurgery (GKRS) to resection cavities remains variable. Quantitative risk stratification using routinely available treatment-time variables…
  pubmed Reyes JS, Bouras A, Lunsford LD, Niranjan A 等 2026 Jul 10 置信度 0.82
• Early Versus Late(r) Administration of Intrapleural Fibrinolytic Therapy in Children with Empyema: A Systematic Review and Meta-Analysis.
  Although intrapleural fibrinolytic therapy (IPFT) is frequently used in empyema thoracis, there is lack of clarity regarding the ideal timing of its administration.
  pubmed Kaur D, Kumar K, Mishra P, Santuka N 等 2026 Jul 10 置信度 0.82
• Botulinum Toxin A Myths, Evidence, and Global Media Narratives.
  Botulinum Neurotoxin A (BoNT-A) is clinically safe and effective, yet public discourse remains saturated with myths. This review investigates how misconceptions are produced and sustained within peer-reviewed literature and traditional media.
  pubmed Sayed K, Nicoloso M, Sokratous E, Shahsavari M 2026 Jul 10 置信度 0.82
• EVERolimus effectiveness after proGREssion on ENdocrine therapy plus CDK4/6 inhibitor for ER-positive/HER2-negative advanced breast cancer: EVERGREEN study.
  There is limited evidence supporting the addition of everolimus to endocrine therapy in women with ER-positive/HER2-negative advanced breast cancer disease progression on CDK4/6 inhibitors. We aimed to assess the effectiveness and safety of everolimus in this …
  pubmed Martins-Branco D, Lobo-Martins S, Aftimos P, Pereira B 等 2026 Jul 10 置信度 0.82
• Insights into the food safety implications of a commercial Bacillus thuringiensis product in hydroponic systems.
  This study examined the food safety implications of a commercial Bacillus thuringiensis (Bt) product by assessing its pathogenicity and impact on the microbiological quality of crops grown in hydroponic systems. B. thuringiensis B3 isolated from the product sh…
  pubmed Ten MMZ, Arifin-Wong N, Tan LJY, Swarup S 等 2026 Aug 19 置信度 0.82
• A neuraminidase-targeted nanobody confers broad protection against influenza B virus.
  Influenza B virus (IBV) exhibits antigenic diversity and significantly contributes to the annual burden of influenza-related disease, posing substantial impacts on global public health and the economy. In this study, we focused on the neuraminidase (NA) of IBV…
  pubmed Jia H, Lin C, Guo Y, Cai W 等 2026 Aug 18 置信度 0.82
• From study design to executable code: automating target trial emulation with large language models.
  Implementing target trial emulation (TTE) studies as standardized, reproducible analytic workflows is technically demanding. We developed Text-guided Health-study Estimation and Specification Engine Using Strategus (THESEUS), which uses large language models (…
  pubmed Kim H, Kim M, Kim S, You SC 2026 Aug 置信度 0.82
• A Pilot Study Protocol for AI-Assisted Interpretation of Chest X-rays for Pulmonary Abnormalities in Uganda.
  Timely access to chest X-ray (CXR) imaging and interpretation remains a practical challenge in routine pulmonary care in Uganda, particularly in settings with limited specialist availability and diagnostic capacity. This study aims to develop a structured, loc…
  pubmed Obungoloch J, Tumusiime J, Nkwanga J, Godfrey MR 等 2026 Jun 置信度 0.82
• Etiological surveillance of viral gastroenteritis in children aged less than 5 years in Tehran Province, Iran, 2023-2024.
  Acute gastroenteritis (AGE) is a primary cause of death in children less than five years old in low- and middle-income countries (LMIC), mostly caused by viral intestinal infections. While the disease poses a significant global burden, further investigation is…
  pubmed Fakhr SSH, Karami H, Shafiei M, Ahmadi Z 等 2026 Jul 10 置信度 0.82
• Methionine restriction plus vitamin B12 antagonism overcomes methionine independence for cancer therapy.
  Methionine dependence represents a well-known metabolic vulnerability in cancer. Despite promising preclinical results, methionine restriction is impaired by the presence of methionine-independent cancer cells. After confirming both inter- and intra-tumoral he…
  pubmed Lacombe V, Aurrière J, Mellinger A, Khiati S 等 2026 Oct 1 置信度 0.82
• Fixed-duration pirtobrutinib plus venetoclax-rituximab versus venetoclax-rituximab for patients with previously treated chronic lymphocytic leukaemia or small lymphocytic lymphoma (BRUIN CLL-322): an open-label, multicentre, randomised, controlled, phase 3 trial.
  Venetoclax-rituximab (VR) following covalent Bruton tyrosine kinase (BTK) inhibitor therapy is the fixed-duration standard of care for patients with chronic lymphocytic leukaemia (including small lymphocytic lymphoma). Pirtobrutinib, a non-covalent BTK inhibit…
  pubmed Davids MS, Eyre TA, Woyach JA, Roeker LE 等 2026 Aug 1 置信度 0.82
• Comparative effectiveness of game-based learning modalities in nursing and medical education: a systematic review and Bayesian network meta-analysis.
  Game-based learning (GBL) is increasingly used in healthcare education, but educators must choose among diverse modalities (e.g., quiz platforms, apps, serious games and metaverse environments). Comparative evidence on which modalities perform best across lear…
  pubmed Chen YJ, Chang LF, Yin MF, Lin YC 等 2026 Jul 5 置信度 0.82
• Risk of Severe Coronavirus Disease 2019 (COVID-19) in Pregnant and Postpartum Individuals After the Pandemic Emergency.
  To evaluate the risks of severe coronavirus disease 2019 (COVID-19)-related outcomes among pregnant and postpartum individuals and nonpregnant women during the Delta variant period and after the pandemic emergency ended in the United States.
  pubmed Coates MM, Arah OA, Rowe SL, Sullivan SG 等 2026 Jul 9 置信度 0.82
• Leveraging microcredentials for sustainability literacy in higher education: A case study of reflective thinking and learning impact in science.
  Microcredentials are becoming increasingly popular in higher education. Despite their growing popularity, there is limited exploration of microcredentials' potential for lifelong learning and their role in sustainability education within curricula. Furthermore…
  pubmed Vermeulen BL, Old JM, Moffitt MC, Dollin J 2026 置信度 0.82
• Microbial Etiology of Empyema Thoracis in Children: A Systematic Review and Meta-Analysis.
  Identifying the microbial etiology of empyema is crucial to implement contextually appropriate clinical management and prevention strategies. However, there is no systematic review examining this question.
  pubmed Purohit A, Das RR, Kapoor R, Paharia P 等 2026 Jul 9 置信度 0.82
• Thoracic Computed Tomography Scan Versus Thoracic Ultrasonography for Management Decisions in Empyema Thoracis: A Systematic Review.
  Although thoracic ultrasonography (USG) provides valuable information for managing empyema, many clinicians resort to thoracic computed tomography (CT) scans.
  pubmed Kaur D, Kumar K, Mishra P, Reddy M 等 2026 Jul 9 置信度 0.82
• Epigenetic editing approaches maturity: AI-driven precision design, delivery innovation, and the road to clinical translation.
  Epigenetic editing achieves durable gene silencing through targeted modification of chromatin and DNA methylation states without altering the genomic sequence-modifications that remain fundamentally reversible compared with genome editing. Long constrained by …
  pubmed Chang S, Lu D, Jin Y, He Y 等 2026 Jul 9 置信度 0.82
• Vector-borne pathogens in dogs from different regions of Afghanistan.
  Canine vector-borne pathogens (CVBPs) are increasingly relevant, particularly those of zoonotic concern, due to climate change and increased animal mobility. However, there is no information on the actual burden of these infections in canine populations in sev…
  pubmed Sazmand A, Carbonara M, Fasehi Z, Annoscia G 等 2026 Jul 8 置信度 0.82
• Integrating harm reduction interventions for older adults in opioid treatment programs: a qualitative study of patient and provider perspectives.
  The prevalence of opioid use disorder (OUD) among older adults has increased rapidly, yet this population faces unique challenges in accessing harm reduction services within opioid treatment programs (OTPs). The objective of this study was to explore patient a…
  pubmed Kepner W, Han BH, Nguyen AL, Bejarano-Romero R 等 2026 Jul 8 置信度 0.82
• Organizational determinants of professional ethics among healthcare workers: implications for health system performance.
  Professional ethics is a critical component of healthcare workforce performance and plays an essential role in patient safety, service quality, and organizational accountability. However, professional ethics may be influenced by workplace conditions and indivi…
  pubmed Chollou KM, Babazadeh T, Rostami AH, Arabnezhad S 等 2026 Jul 8 置信度 0.82
• Enhancing semantic interoperability in precision medicine: converting OMOP CDM to Beacon v2 in the Spanish IMPaCT-Data project.
  To evaluate a file-based approach for converting OMOP CDM data into GA4GH Beacon v2 format and outline an alternative on-the-fly architecture for real-time access, with the aim of enhancing semantic interoperability within Spain's IMPaCT-Data program for perso…
  pubmed Rueda M, Ramírez-Anguita JM, López-Sánchez V, Aguiló-Castillo S 等 2026 Jul 8 置信度 0.82
• Struggling to integrate artificial intelligence in prehospital emergency care in a developing country: exploration of the Iranian experts' views based on qualitative content analysis.
  The use of integrated artificial intelligence (AI) in prehospital emergency services can not only increase the quality of services, but also help save patients' lives and improve treatment outcomes. Given the challenges in emergency medicine, this technology i…
  pubmed Hadian M, Tavakoli N, Khanbebin MJ, Nouri M 等 2026 Jul 8 置信度 0.82
• A Di-Rhamnolipid (Rha(2)-C(10)-C(10)) Inhibits Colorectal Cancer Motility and Immune Evasion Through AKT-Associated Signaling and PD-L1 Regulation.
  Colorectal cancer (CRC) progression is driven by metastatic potential, metabolic reprogramming, and immune evasion. In this study, we investigated the effects of a di-rhamnolipid, Rha 2 -C 10 -C 10 (1), on CRC cell motility, energy metabolism, and immune-relat…
  pubmed Pulat S, Hillman PF, Ko J, Nam SJ 等 2026 Jul-Aug 置信度 0.82
• Machine Learning to Identify Bacteremia and Meningitis in Febrile Infants: A Systematic Review.
  The accurate identification of febrile infants who are at risk for invasive bacterial infections (IBIs), ie, bacteremia and meningitis, is essential to reduce morbidity and avoid unnecessary procedures. The role of machine learning (ML) in improving their diag…
  pubmed Ferraris G, Tazzoli S, Folisi C, Pisani L 等 2026 Aug 1 置信度 0.82
• Characterization of oseltamivir-resistant A(H5N1) clade 2.3.4.4b, genotype D1.1 variants identified in poultry farms of British Columbia, Canada.
  Highly pathogenic avian influenza A(H5N1) viruses of clade 2.3.4.4b, genotype D1.1, are responsible for widespread outbreaks in poultry and continue to cause sporadic, sometimes severe, human infections. Herein, we characterized a wild-type (WT) influenza A(H5…
  pubmed Cochin M, Abed Y, Vendramelli R, Dionne K 等 2026 Dec 置信度 0.82
• Functional and morphometric outcome of adaptable slicing condylectomy in transverse condylar hyperplasia: A deep learning-enhanced 3D study.
  Unilateral condylar hyperplasia (UCH) with transverse mandibular deviation is a frequent cause of facial asymmetry and skeletal Class III malocclusion. Adaptive slice condylectomy (ASC) has been proposed as a focused alternative to bimaxillary orthognathic sur…
  pubmed Spallaccia F, Committeri U, Giovannoni ME, Ricciardi A 等 2026 Sep 置信度 0.82
• My Voice Library: Protocol for Developing Audio and Visual Datasets to Enable Personalized Real-Time Communication for People With Dysarthria.
  Communication is a human right; despite this, children with cerebral palsy and dysarthria experience constraints due to their physical disability, affecting their opportunity to reach their full potential and ability to fully participate in play, school, and s…
  pubmed Karlsson P, Bandini A, McInerney M, Smithers-Sheedy H 等 2026 Jul 8 置信度 0.82
• IL-17A, IL-17RA, and IL-22 as biomarkers in migraine: associations with disease activity and clinical features.
  Migraine is increasingly recognized as a neuroinflammatory disorder involving immune-mediated mechanisms. Th17-related cytokines, including interleukin-17 A (IL-17 A) and interleukin-22 (IL-22), together with the IL-17 receptor A (IL-17RA), may contr…
  pubmed Turna Saltoglu G, Yalcın Azarkan S, Koysuren A, Celıkbılek A 2026 Jul 8 置信度 0.82
• Data-driven refinements for voice disorder classification: improving accuracy and generalisability.
  As machine-learning models for vocal pathology advance, their performance is increasingly constrained not by modelling techniques but by the taxonomic structures used to define the classification task itself. Conventional clinical frameworks, while grounded in…
  pubmed Gupta R, Madill C, Jin C 2026 置信度 0.82
• Diagnostic accuracy of artificial intelligence for tuberculosis detection from cough sounds: a systematic review and meta-analysis.
  Tuberculosis (TB) remains the leading cause of death from infectious diseases globally, with significant diagnostic challenges in low- and middle-income countries. Artificial intelligence (AI) analysis of cough sounds could offer an inexpensive and accessible …
  pubmed Sahoo RK, Sahoo KC, Sinha A, Talukdar R 等 2026 置信度 0.82
• Structural Optimization Strategy for α,β-Unsaturated Ketone TrxR Inhibitors: From Enhanced Pharmacokinetics to Improved Tumor Selectivity.
  Thioredoxin reductase (TrxR), a master regulator of intracellular redox homeostasis, is a validated antitumor target. α,β-Unsaturated ketones are potent irreversible TrxR inhibitors with robust in vitro anticancer activity, yet their clinical trans…
  pubmed Wang X, Du Y, Ning W, Shen B 等 2026 Jun 置信度 0.82
• Nicotine and tobacco product use among US middle and high school students, 2024-25.
  The overall prevalence of youth nicotine and tobacco product use has declined over recent years, but the product landscape continues to change rapidly. This study examined changes between 2024 and 2025 in the prevalence of nicotine and tobacco product use amon…
  pubmed Sun H, Jiang Y, Tattan-Birch H, Fan S 等 2026 Jul 7 置信度 0.82
• Virtual simulation as a catalyst for equitable and authentic interprofessional learning.
  Interprofessional education (IPE) is essential for preparing health sciences students for collaborative practice, yet its implementation remains constrained by geographical dispersion, scheduling conflicts, and variability across clinical placements. Advances …
  pubmed Molabe M, Rasesemola R, Matlala S, Matshaka L 2026 Jul 7 置信度 0.82
• The doctors of the future: the competition of ChatGPT-4, ChatGPT-4 omni, and Gemini 2.0 Flash in andrology.
  Large language models (LLMs) are increasingly being used in medical research and as clinical decision-support tools. This study aimed to compare the accuracy and reliability of responses generated by large language models in response to andrology-related quest…
  pubmed Uysal U, Alma E, Altunkol A, Ercil H 等 2026 Jul 7 置信度 0.82
• Cross-Center Online Generalization Algorithm with Unadversarial Consistency for Fetal Heart Ultrasound View Recognition.
  Fetal congenital heart disease (FCHD) remains a leading cause of infant mortality globally, yet the clinical deployment of deep learning models for automated fetal echocardiographic view recognition faces performance degradation due to domain shifts across med…
  pubmed Liu Y, Liang T, Tian J, Jiang N 等 2026 Jul 7 置信度 0.82
• From Etiology to Aesthetic Surgery: Mapping Knowledge Domains and Emerging Trends in Gynecomastia Research: 35-Year Bibliometric Analysis.
  Gynecomastia is a benign proliferation of glandular tissue in the male breast, with incidence rate of 30-60% among adolescents. Its etiology involves physiological hormonal fluctuations, pathological conditions, and pharmacologic factors. It causes psychologic…
  pubmed Deng K, Liu Y, Tang Y, Xie N 2026 Jul 7 置信度 0.82
• Longitudinal multiomics profiling of extracorporeal cross-circulation with pig liver xenografts in human decedents.
  Extracorporeal liver cross-circulation (ELC) using gene-edited porcine liver xenografts offers a potential bridge therapy for liver failure. We previously performed five ELC procedures in four brain-dead human decedents, during which the recipients developed s…
  pubmed Guo Q, Wang C, Mauduit V, Stukalov A 等 2026 Aug 置信度 0.82
• Towards clinically reliable AI: comparative evaluation of CNN, transformer, and hybrid architectures for meningioma detection and segmentation.
  Accurate and clinically reliable meningioma detection from brain MRI remains a critical challenge, requiring not only high predictive performance but also robust interpretability. In this study, we systematically evaluated convolutional neural networks (CNNs),…
  pubmed Dağlı Ö, Ekinci F, Hazar G, Turan B 等 2026 Jul 7 置信度 0.82
• Chinese expert consensus on radiotherapy combined with immunotherapy for unresectable lung cancer (2026 Edition).
  In recent years, the combination of radiotherapy and immunotherapy has emerged as a major focus of research in the treatment of unresectable lung cancer. With a growing understanding of the synergistic mechanisms between radiotherapy and immunotherapy, togethe…
  pubmed Wang L, Liu Y, Zhao W, Xing L 等 2026 Oct 1 置信度 0.82
• PU-GRAIL: residue-level graph learning for identifying protective bacterial antigens under positive-unlabeled supervision.
  The identification of protective antigens is fundamentally constrained by sparse annotations and pervasive label uncertainty in reverse vaccinology. Protective antigen-antibody interactions are mediated by a limited subset of surface-accessible residues that f…
  pubmed Jeon J, Jung S, Jung I, Kim K 等 2026 Jul 1 置信度 0.82
• Αdaptation and Psychometric Validation of the Female Genital Self-Image Scale in a Greek Population.
  Female genital self-image is an important factor influencing women's sexual function and overall psychological well-being. However, a culturally adapted and validated instrument for assessing this construct in the Greek population has not yet been established.…
  pubmed Gkola C, Harizopoulou V, Mikos T, Goulis DG 等 2026 Jul 7 置信度 0.82
• The Role of Hippocampal Microglial cGAS-STING Signaling Pathway in Postoperative Cognitive Dysfunction in Diabetic Mice.
  This study aimed to determine whether activation of the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway within hippocampal microglia contributes to postoperative cognitive dysfunction (POCD) in a diabetic mouse model. Diabetes was…
  pubmed Ning J, Chen M, Liu J, Zhang G 等 2026 Jun 22 置信度 0.82
• Aptamer-based inhibition of MNK1 reduces pancreatic ductal adenocarcinoma growth by targeting cancer stem cells.
  Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers due to late diagnosis, early metastasis and resistance to therapy. Cancer stem cells (CSCs) have been implicated in PDAC aggressiveness and treatment failure. MAP kinase-interacting k…
  pubmed Pérez-Ruiz A, Ruiz-Cañas L, Batres S, Ferreras-Martín R 等 2026 Jul 6 置信度 0.82
• Sirtuin 1 deficiency mediates chronic kidney disease-induced inflammaging cardiovascular calcification.
  Chronic kidney disease (CKD) markedly accelerates calcific aortic valve disease (CAVD), yet the underlying mechanisms and therapeutic targets remain poorly defined. Here, we integrate population-scale analyses, single-cell transcriptomics, genetic inference an…
  pubmed Xu L, Zheng Y, Liu M, Deng B 等 2026 Jul 7 置信度 0.82
• Two faces of drug repurposing data in machine learning-driven structure-based virtual screening supported by interaction fingerprints.
  Ensemble docking is a prominent source of protein-ligand complex structures, which could be conveniently analyzed with interaction fingerprints approach in a machine learning framework. Nevertheless, the chemical nature and provenance of the source data librar…
  pubmed Fomina AD, Osolodkin DI 2026 Jul 6 置信度 0.82
• Turnover Time in Neuroangiography Suites: Comparison Between Cases Performed at an Ambulatory Neurosurgery Center Versus a Tertiary Hospital.
  Efficient turnover time (TOT) and adherence to first-start time (FST) in operating and angiography suites are critical for optimizing workflow, reducing costs, and maximizing patient satisfaction. Hospitals face challenges in maintaining these metrics due to o…
  pubmed Lai PMR, Jaikumar V, Leasher EL, Sridhar V 等 2026 Jul 置信度 0.82
• Sex Differences in the Protective Effect of Brain Volume: Age Attenuates Protection in Women.
  Sex differences in outcomes after acute ischemic stroke are well recognized, but mechanisms remain unclear. This study evaluates whether parenchymal brain volume (PBV), age, and final infarct volume explain sex-specific differences in poststroke disability.
  pubmed Gomez-Farias J, Le NM, Samaha JN, Kfoury B 等 2026 Jul 置信度 0.82
• Thematic Evolution in Medical Education Research (2000-2024): A Large-Scale BERTopic Analysis.
  Few large-scale, semantically informed mappings of medical education research exist: traditional methods such as keyword co-occurrence and Latent Dirichlet Allocation cannot capture the contextual meaning of scientific abstracts. This study aimed to identify m…
  pubmed Chen C, Li J, Zhang Z, Zhang T 2026 置信度 0.82
• A Systematic Review and Meta-analysis on Innovative Approaches in Tuberculosis Diagnosis: Challenges and Future Directions.
  Tuberculosis (TB) has continued to be one of the global threats, affecting millions of individuals globally, including the maternal and child health (MCH) populations and individuals with HIV/AIDS. TB infected 10.8 million individuals, leading to 1.25 million …
  pubmed Abdulhadi A, Abdullahi N, Yusuf I, Waziri BI 等 2026 置信度 0.82
• The Metaverse in Ophthalmology: Application and Perceived Benefits, Challenges, Realistic Expectations, and Future Outlook.
  To explore the potential of the metaverse, a three-dimensional platform merging physical and virtual realities (VRs), in advancing the field of ophthalmology. This study examines its applications in areas such as VR-based surgical training, augmented reality (…
  pubmed Abubaker Y, Mahameed D, Ahuja AS, Abukhaled Y 等 2025 Oct-Dec 置信度 0.82
• From wrinkled seeds to plant oil accumulation networks: the legacy of a Plant Physiology classic.
  Plant seeds accumulate triacylglycerol (TAG) as a major storage reserve that supports postgermination growth and seedling establishment. Vegetable oils are also essential for human nutrition and provide renewable feedstocks for industrial and biotechnological …
  pubmed Kong Q, Pattanaik S, Kong F, Guo L 等 2026 Aug 4 置信度 0.82
• Sex estimation from morphometry of lumbar vertebrae (L4-L5): A machine learning approach.
  Sex estimation is the first and most important step in establishing a reliable biological identity during the examination of skeletal remains. For sex estimation, the pelvis and cranial bones are primarily preferred. In cases where the pelvis bones are not ava…
  pubmed Ayturk BG, Keles A, Osmanoglu UO 2026 Jul 4 置信度 0.82
• Lasiokaurin suppresses hepatocellular carcinoma proliferation and induces apoptosis via the JAK2/STAT3 pathway.
  The antitumor effects of Lasiokaurin (LAS), a natural compound derived from traditional Chinese medicine extracts, remain poorly understood in hepatocellular carcinoma (HCC). Therefore, this study investigates the anticancer effects of LAS in liver cancer. The…
  pubmed Tian H, Zhou H, Ouyang Y, Xiao K 2026 Jul 4 置信度 0.82
• A dual-mode aptasensor based on UiO-66-NH₂@MOF-919 for subtype-specific detection of carbapenem-resistant Klebsiella pneumoniae.
  Rapid and reliable detection of multidrug-resistant bacteria is essential for effective clinical management. In this study, we have developed a dual-mode aptasensing platform based on a core-shell MOF-on-MOF structure (UiO-66-NH₂@MOF-919) for the subtyp…
  pubmed Li R, Shen H, Shi D, Yu S 等 2026 Jul 3 置信度 0.82