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Influenza viruses are characterized by high mutation rates and extensive genetic diversity, which hinder effective vaccine development and facilitate immune evasion (Taubenberger & Morens, 2006; Barr et al., 2010). These mutations primarily arise from the erro…
preprints
2025
置信度 0.74
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Background Systematic reviews are essential for evidence-based decision making in health sciences but require substantial time and resource for manual processes, particularly title and abstract screening. Recent advances in machine learning and large language …
preprints
2026
置信度 0.74
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Abstract While artificial intelligence (AI) is increasingly integrated into environmental research, a systematic evaluation of this integration remains limited. In response to this, we analyzed a representative sample of 106 articles from Nature and Science (2…
preprints
2025
置信度 0.74
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Abstract The global incidence of skin cancer continues to rise. Dermal therapists, licensed allied health professionals (AHPs), play an important role in risk screening; however, their accuracy in identifying suspicious skin lesions remains unevaluated. This s…
preprints
2026
置信度 0.74
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At a time of economic turmoil and accelerated technological change, the resilience and sustainability of organizations and cities are put to the test like never before. The paper presents a study on how a more interdependent use of three strategic enablers, Ar…
preprints
2025
置信度 0.74
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Background: /Objectives: Radiotherapy, radiobiology, and oncology have evolved rapidly over the past six decades, generating vast and fragmented bodies of scientific evidence. This study aimed to systematically map and interpret their conceptual and temporal d…
preprints
2025
置信度 0.74
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Smart farming has established itself as a strategic field in the digital and sustainable transformation of the agri-food sector. The rise of technologies such as the Internet of Things (IoT), artificial intelligence (AI), machine learning, big data, and blockc…
preprints
2025
置信度 0.74
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Abstract Background Personal health data contain valuable information for breast cancer management. Integration of heterogeneous data and maintenance of clinical registries are time-consuming and labor-intensive. We aimed to leverage an Artificial Intelligence…
preprints
2026
置信度 0.74
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ABSTRACT Estimating dengue force of infection (FOI) is essential for understanding transmission dynamics and targeting intervention programmes, yet surveillance data in endemic settings required for estimations are often incomplete, with varying formats. We de…
preprints
2026
置信度 0.74
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Antimicrobial resistance (AMR) surveillance requires approaches that monitor both clinical and community-level dynamics. We monitored antibiotic-resistant bacteria in Swiss wastewater and compared these results with human resistance and antibiotic consumption …
preprints
2025
置信度 0.74
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Clinical prediction models are often created using large routinely collected datasets. It is essential that prediction models are developed with appropriate data and methods and transparently reported to ensure that decisions are based on reliable predictions.…
preprints
2026
置信度 0.74
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Abstract Background/Objectives: The collection of regional anthropometric and body composition data is essential for medical and epidemiological research, as it allows for the customization of prevention and treatment strategies based on the specific character…
preprints
2026
置信度 0.74
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Abstract Digital dashboards have become integral tools for data-driven decision-making, yet variations in design principles, user focus, and performance impact limit their standardization and strategic optimization. This systematic review examined the design p…
preprints
2025
置信度 0.74
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Abstract Technological complexity and variability have long been central to archaeological inquiry, given their implications for human modernity, social networks, and cultural transmission. The reverse phenomenon, technological simplicity, has received compara…
preprints
2026
置信度 0.74
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Abstract Objective To identify sociodemographic, experiential and attitudinal determinants of public trust in artificial intelligence (AI) and software as a medical device (SaMD) in UK healthcare, focusing on trust in AI-assisted clinical decision-making under…
preprints
2026
置信度 0.74
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Background White matter hyperintensities (WMH) represent the most visible manifestation of cerebral small vessel disease and of white matter pathology more broadly, yet empirical evidence points to a brain tissue injury extending beyond radiologically detectab…
preprints
2026
置信度 0.74
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Abstract Academic publishing is facing growing concerns related to reproducibility, peer review, and accessibility, yet proposed reforms have produced limited systemic change. We examined academic publishing as a complex adaptive system by conducting a themati…
preprints
2026
置信度 0.74
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Abstract Semen technologies (STs) have been increasingly used in birds as a resource to overcome difficulties commonly faced by conservation breeding programs. Yet their application endures challenges not only related to avian physiology but also in terms of e…
preprints
2026
置信度 0.74
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The objective of this study review is to identify methodological biases in publicly available virological studies, motivated by a review and examination of early SARS-CoV-2. A narrative critical review of virology literature (1930-2024) has been conducted. Lit…
preprints
2025
置信度 0.74
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Abstract There is an urgent need to reduce carbon emissions globally to limit the damages caused by climate change. Most economists agree that a carbon price is an effective and cost-efficient policy to mitigate emissions, yet low public acceptance and limited…
preprints
2026
置信度 0.74
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In this paper, we argue that the behavioral sciences and organizational psychology should extend its consideration to AI workers, particularly as large language models (LLMs) are increasingly integrated into organizational contexts. Building on recent research…
preprints
Andrew Samo
2025
置信度 0.74
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In recent years, the rapid development of artificial intelligence (AI) has spurred significant advances across a range of disciplines, not least in the domain of sustainable life sciences. This research paper investigates implemented AI solutions in sustainabl…
preprints
2025
置信度 0.74
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Summary Dysregulation of Polycomb Repressive Complex 2 (PRC2) is established to contribute to cancer. Of its catalytic subunits, EZH1 and EZH2, EZH2 mutations in cancer have been extensively identified and studied, but the role of EZH1 in cancer remains largel…
preprints
2025
置信度 0.74
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Background Redundant publication, the practice of submitting the same or substantially overlapping manuscripts multiple times, distorts the scientific record and wastes resources. Since 2022, publications using large open-science data resources have increased …
preprints
2025
置信度 0.74
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Three-dimensional (3D) cell spheroids are widely used as in vitro tissue models, yet quantitative understanding of their morphogenesis remains limited. We present an integrated experimental–computational framework to analyze, model, and modulate the compaction…
preprints
2025
置信度 0.74
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Professor Nir Eisikovits (2023) recently advanced the theory that Artificial Intelligence (AI) poses an existential risk to humanity, but one that is philosophical rather than apocalyptic. While film and television has explored the latter outcome of the use of…
preprints
2025
置信度 0.74
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Abstract Artificial Intelligence based Learning Tools (AI-LTs) are rapidly transforming higher education by enhancing teaching, learning, and administration. This study systematically reviews peer-reviewed literature from 2020 to 2024 to explore the roles, ben…
preprints
2025
置信度 0.74
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Abstract Aging research has been advanced largely through the use of model organisms, where short lifespans and genetic tractability enable the systematic discovery of molecular pathways influencing longevity and age-related decline. However, knowledge about a…
preprints
2026
置信度 0.74
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1. ABSTRACT Purpose Radiotherapy treatment planning is a resource-intensive process characterized by multiple manual steps and clinical hand-offs that contribute to treatment delays and inter-observer variability. The Radiation Planning Assistant (RPA) is a we…
preprints
2025
置信度 0.74
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Abstract This study presents a comprehensive and pedagogically grounded bibliometric and predictive investigation into the integration of artificial intelligence (AI) within science education. By applying advanced bibliometric techniques and predictive modelin…
preprints
2025
置信度 0.74
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Three-dimensional electron microscopy (3D EM) enables the quantitative analysis of cellular ultrastructure. However, large-scale segmentation of whole-cell volumes poses a significant challenge, especially in biologically diverse systems. Unlike medical and an…
preprints
2026
置信度 0.74
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Objective Artificial intelligence (AI) and machine learning (ML) are widely used in healthcare, primarily for clinical tasks like diagnostics and decision support. However, their role in organization- and system-level processes, such as resource allocation and…
preprints
2025
置信度 0.74
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Abstract Objective This study aims to investigate the high-risk factors and ultrasonic examination of prenatal stillbirth caused by umbilical cord torsion (UCT). Method We retrospectively analyzed the electronic data of 424 pregnant women with UCT who delivere…
preprints
2025
置信度 0.74
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Abstract The adoption of artificial intelligence in dermatology promises democratized access to healthcare, but model reliability depends on the quality and comprehensiveness of the data fueling these models. Despite rapid growth in publicly available dermatol…
preprints
2026
置信度 0.74
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Abstract To improve climate communication, it is crucial to understand how different audiences respond to pro-climate messages, particularly in information environments where accurate information competes with climate-contrarian disinformation. Here, we analyz…
preprints
2026
置信度 0.74
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This study presents a comprehensive bibliometric review of robot-assisted language learning (RALL) from 2003 to 2025, analyzing 439 publications from Web of Science, Scopus, PubMed, and Dimensions. Using Biblioshiny and VOSviewer, we mapped publication pattern…
preprints
2025
置信度 0.74
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Accurate long-term forecasting of cognitive trajectories across the Alzheimer’s disease continuum is essential for early intervention, personalized prognosis, patient stratification, and clinical trial enrichment. Despite the promising predictive performance o…
preprints
2026
置信度 0.74
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Abstract Background Digital transformation in health sciences education is accelerating, yet little is known about how institutional strategies, pedagogical models, and technology adoption intersect in practice. Anaesthesiology, a high-stakes and procedurally …
preprints
2025
置信度 0.74
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Abstract The discovery of novel odorant molecules is key for the fragrance and flavor industries, yet efficiently navigating the vast chemical space to identify structures with desirable olfactory properties remains a significant challenge. Generative artifici…
preprints
2026
置信度 0.74
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Background Administering and interpreting intelligence tests for adults with visual impairment (VI) presents practical and methodological challenges, because standard test batteries rely heavily on visual tasks and lack specific norm-groups tailored to this po…
preprints
2026
置信度 0.74
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Abstract Background Communication skills are central to clinical practice and are typically assessed through Objective Structured Clinical Examinations (OSCEs). Prior research indicates that self-report questionnaires, simulated-patient evaluations, and expert…
preprints
2026
置信度 0.74
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ABSTRACT Background Impaired glymphatic clearance, the perivascular system supporting cerebrospinal and interstitial fluid exchange, has been implicated in neurodegenerative and psychiatric disorders. Diffusion tensor imaging along the perivascular space (DTI-…
preprints
2026
置信度 0.74
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Background The faecal immunochemical test (FIT) is central to triaging symptomatic patients with suspected colorectal cancer (CRC) in UK primary care, yet only about one in eleven patients above the NICE 10 µg/g threshold have CRC. Existing prediction models a…
preprints
2026
置信度 0.74
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Background Unintended pregnancies can introduce stress and shift life trajectories. Social support may buffer these effects, yet its influence during an unintended pregnancy and into the early parenthood period is not clear. This study aimed to understand the …
preprints
2026
置信度 0.74
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While pregnancy intentions are increasingly recognised as complex and dynamic, unexpected pregnancies are often studied cross-sectionally, and a life course perspective is lacking. This study aimed to explore the salient themes and patterns in 1) the life cour…
preprints
2026
置信度 0.74
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Cancer tissue analysis in digital pathology is typically conducted across different spatial scales, ranging from high-resolution cell-level modeling to lower-resolution tile-based assessments. However, these perspectives often overlook the structural organizat…
preprints
2025
置信度 0.74
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Abstract Background: Artificial intelligence (AI) is evolving and expanding at an unprecedented rate across healthcare and education. AI for sexual health education has the potential to reduce sexual health stigma, provide convenience for many populations of a…
preprints
2025
置信度 0.74
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Background UK clinical guidance recommends that structured risk prediction tools and risk stratification should not be used in self-harm, to predict suicide or determine who is offered treatment. Underpinning this position is the premise that routinely collect…
preprints
2026
置信度 0.74
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Abstract Non-invasive brain stimulation (NIBS), including transcranial magnetic stimulation (TMS) and transcranial electrical stimulation (tES), is a growing class of mental health treatment, yet acceptability among people with lived or carer experience is poo…
preprints
2026
置信度 0.74
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Contemporary AI models owe much of their success and discontents to connectionism, a framework in cognitive science that has been (and continues to be) highly influential. Herein, we analyze artificial neural networks (ANNs): a) when used as scientific instrum…
preprints
2025
置信度 0.74
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Abstract Background: African health care Systems are confronted by continuing infrastructure disparities or lack of capacity about the workforce and unequal access to care. To address these challenges, artificial intelligence (AI) and data governance framework…
preprints
2025
置信度 0.74
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Abstract We present the Stability constrained model of protein evolution (SCPE) in the pairwise approximation. This model enforces protein folding stability, both against unfolding and against misfolding, which we predict with a statistical physics model based…
preprints
2026
置信度 0.74
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Background: Diagnosing leukemia from bone marrow biopsies or aspiration smears is expert-dependent and time-consuming. The rise of machine learning(ML) and deep learning(DL) offers a promising avenue for automating image analysis, though approaches across the …
preprints
2025
置信度 0.74
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The rapid advancements in Internet of Things (IoT) and Artificial Intelligence (AI) over the past decade have significantly influenced national development through science and technology. This study synthesizes 40 literature from 2017 to 2024 to assess the imp…
preprints
2025
置信度 0.74
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Background: In light of the concerning increase in burnout among healthcare professionals, it is essential to identify the specific factors that contribute to this phenomenon and that can be addressed. This review examines the relationship between burnout and …
preprints
2025
置信度 0.74
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Background Long-term oxygen therapy (LTOT) is essential for patients with chronic hypoxemia, particularly due to chronic obstructive pulmonary disease (COPD). However, conventional LTOT relies on static oxygen flow rates that fail to reflect patients’ fluctuat…
preprints
2025
置信度 0.74
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Abstract Educational environments place sustained demands on attention and self-regulation during a period of rapid brain development. Yet it remains unclear whether everyday schooling contexts are associated with differences in the maturation of neural system…
preprints
2026
置信度 0.74
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Abstract Background Exercise is an important component of managing Long-Term Conditions (LTCs) and can improve health outcomes. Artificial intelligence (AI)-based exercise prescription software has the potential to support exercise amongst people with LTC. How…
preprints
2025
置信度 0.74
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Children with developmental language disorder (DLD) have persistent language learning difficulties and often perform poorly on pseudoword repetition, a task that probes phonological, memory, and speech-motor processes that support vocabulary acquisition. Resea…
preprints
2026
置信度 0.74
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The molecular consequences of protein truncating variants depend strongly on whether their transcripts are eliminated by nonsense-mediated mRNA decay (NMD), yet NMD is still predicted largely from a small set of binary positional rules. How individual prematur…
preprints
2026
置信度 0.74
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Background Artificial Intelligence (AI) is at the forefront of today’s technological revolution, enhancing efficiency in many organisations and sectors. However, in some research environments, its adoption is tempered by the risks AI poses to data protection, …
preprints
2025
置信度 0.74
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Background and Aim Opioid use disorder (OUD) is a chronic condition in which an individual engages in the persistent use of opioids that causes significant distress and negatively impacts their societal functioning. Treatment for OUD involves pharmacological t…
preprints
2025
置信度 0.74
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OpenAI launched a tool in the Fall of 2022 that would, intentionally or otherwise, threaten the educational system at its foundation. As students gained access to ChatGPT on their browsers and mobile phones, the temptation to ask for help with schoolwork and t…
preprints
2024
置信度 0.74
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Abstract Background For the effective treatment planning of head and neck cancers, precise tumor segmentation is vital. The combination of artificial intelligence (AI) technology with imaging systems like positron emission tomography (PET) and PET/ computed to…
preprints
2025
置信度 0.74
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Maternal effects play a fundamental role in shaping early larval growth and survival in marine fishes. This study explores the relationship between maternal trophic ecology and larval growth in bluefin tunas, with a focus on Southern Bluefin Tuna (SBT) and an …
preprints
2025
置信度 0.74
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Personality disorder severity (PDS) is a novel measure of personality in the ICD-11 with potential prognostic value. Due to its recent introduction, however, no information on it exists in most clinical cohorts. Here, we explored the value of its replacement i…
preprints
2025
置信度 0.74
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Proteins can bind small molecules with high specificity. However, designing proteins that bind userdefined ligands remains a challenge, typically relying on structural information and costly experimental iteration. While protein language models (pLMs) have sho…
preprints
2026
置信度 0.74
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Stroboscopic light stimulation (SLS) is a candidate non-pharmacological intervention that induces transient visual and affective experiences, with potential application in depression. Before efficacy testing, clinical development requires safety, tolerability …
preprints
2026
置信度 0.74
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Abstract Purpose To map and analyze the evolution, key themes, and global contributions in recruitment research from 1990 to 2025, and to provide recommendations for future research and practice in HR management. Design/methodology/approach This study employed…
preprints
2025
置信度 0.74
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Background: Water security is a growing global challenge that requires effective and sustainable watershed management. Information and Communication Technologies (ICTs) provide innovative tools to support this process, but their applications still demand syste…
preprints
2025
置信度 0.74
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Despite a high publication volume (1996–2024), Brazil lags innovation leaders due to systemic barriers driving researchers toward low-impact journals or research abandonment. One critical and solvable barrier is the absence of interactive tools for top journal…
preprints
2025
置信度 0.74
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Background Mortality from cardiovascular disease (CVD) has seen a dramatic increase over the past decades, which has led to a significant increase in the development of risk prediction models. AI-based models have been proposed as a method of enhancing traditi…
preprints
2025
置信度 0.74
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Abstract Background: In recent years, Artificial Intelligence (AI) technology, represented by deep learning, has flourished, widely empowering various scientific research. At present, it is worth-noting that biological science and computer technology are devel…
preprints
2024
置信度 0.74
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Background Chronic pelvic pain (CPP) affects up to 26% of women worldwide. While its pathophysiology is poorly understood, disturbances in body perception have been identified in various similar chronic musculoskeletal disorders. The Fremantle Perineal Awarene…
preprints
2026
置信度 0.74
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The escalating demands for high-resolution, real-time radiative transfer (RT) modeling in climate science and remote sensing necessitate a paradigm shift beyond classical solvers, such as DISORT and RRTMG, which struggle with spectral complexity, non-LTE physi…
preprints
2025
置信度 0.74
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Artificial Intelligence (AI) is a growing area of Computer Science that combines the technologies with data science to develop intelligent, highly computation-able systems. Its ability to automatically analyse and query huge sets of data has rendered it essent…
preprints
2024
置信度 0.74
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Abstract The proliferation of nanotechnology faces a critical bottleneck: the lack of comparable and reliable nanoscale dimensional measurements across diverse instruments and laboratories that undermines reproducibility and innovation in nanoscale materials, …
preprints
2026
置信度 0.74
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ABSTRACT Background Community pharmacies are a potential route to reach underserved groups due to their locations and staff, who often reflect the diversity of the populations they serve. This study aimed to explore the potential for a uterine cancer awareness…
preprints
2026
置信度 0.74
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Brains are able to extract diverse relations between objects or concepts, and to integrate relational information into cognitive maps that form a basis for decision making. But is has remained a mystery how relational information is learnt and represented by n…
preprints
2025
置信度 0.74
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Abstract As artificial intelligence transforms the landscape of social science research, large language models (LLMs) like ChatGPT present both unprecedented opportunities and unprecedented challenges. This study explores the application of ChatGPT as "surroga…
preprints
Antonina Rafikova, Anatoly Voronin
2024
置信度 0.74
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Abstract Background Oral cancer remains a significant global public health issue, with high incidence and mortality rates. Despite the availability of screening programs and advancements in diagnostic technologies, participation in oral cancer screening remain…
preprints
2025
置信度 0.74
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Abstract Background: Zero-dose (ZD) children remain a critical public health concern, particularly in low- and lower-middle-income countries (LLMICs), where over 80% of the global ZD population resides, disproportionately concentrated among the most marginalis…
preprints
2026
置信度 0.74
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This article examines how sensor technologies (such as environmental sensors, biometric sensors, and IoT devices) intersect with conversational AI models like ChatGPT. In particular, this article explores how data from different sensors in real-time can improv…
preprints
2024
置信度 0.74
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Abstract Data science has emerged as an important field in higher education, presenting complex challenges for students due to its interdisciplinary nature involving statistical and computational concepts. In previous research, we introduced the rDSA system to…
preprints
Ivan Letteri, Pierpaolo Vittorini
2024
置信度 0.74
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Background: Artificial intelligence (AI) has emerged as a transformative technology in healthcare, with its integration into cardiac surgery offering significant advancements in precision, efficiency, and patient outcomes. However, a comprehensive understandin…
preprints
2024
置信度 0.74
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In this report, we summarize and analyze the 2024 Adaptyv protein design competition. Participants used computational and Machine Learning (ML) methods of their choice to design proteins that bind the Epidermal Growth Factor Receptor (EGFR), a key drug target …
preprints
2025
置信度 0.74
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Objective The accumulation of DNA damage and mutations is a key contributor to aging. Recent studies have shown that disrupting the Beclin 1-BCL2 autophagy regulatory complex through gene editing can extend lifespan in mice. The precise application of gene edi…
preprints
2025
置信度 0.74
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ABSTRACT How piRNA-mediated genome defense achieves specificity against transposons while sampling a complex transcriptome has remained unresolved. Here we show that piRNA biogenesis operates through pervasive, non-specific sampling of cytoplasmic RNAs, with s…
preprints
2026
置信度 0.74
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SedaDNA has been successfully recovered from diverse contexts, enabling researchers to address paleoenvironmental questions such as ecosystem changes and climatic shifts, along with archaeological questions related to past human activities, diet, health, and i…
preprints
2025
置信度 0.74
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Abstract Background: Type 2 diabetes mellitus (T2DM) is an escalating public health concern across Africa, but regionally tailored predictive models are scarce. Advances in machine learning (ML) offer potential for early identification, though previous researc…
preprints
2025
置信度 0.74
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`prismAId` is an open-source tool designed to streamline systematic literature reviews by leveraging generative AI models for information extraction. It offers an accessible, efficient, and replicable method for extracting and analyzing data from scientific li…
preprints
2024
置信度 0.74
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Background/Aims Diabetic retinopathy (DR) screening using artificial intelligence (AI) has evolved significantly over the past decade. This study aimed to analyze research trends, developments, and patterns in AI-based fundus image DR screening from 2014 to 20…
preprints
2024
置信度 0.74
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Abstract We present NMPA-MedDevice, a regulatory dataset derived from China's National Medical Products Administration (NMPA) Unique Device Identification (UDI) registry. The release comprises four components: (1) a frozen raw snapshot of the NMPA UDI registry…
preprints
2026
置信度 0.74
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Polygenic risk scores (PRSs), which quantify inherited susceptibility to complex traits and diseases, have emerged as valuable tools for risk stratification and precision medicine. Despite their promise, PRS developed on European cohorts often demonstrate subs…
preprints
2026
置信度 0.74
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Deep Science is enabling high-throughput experimentation (HTE) to design novel biological entities with desired properties. E.g., blood-brain-barrier (BBB) crossing adeno-associated virus (AAV) vectors, needed for systemic delivery of gene therapies to brain c…
preprints
2024
置信度 0.74
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Abstract Background The social media (SM) is now widely used for health communication, especially for preventing non-communicable diseases (NCDs). But it is not clear how health communication theories and strategies are used in these social media programs. Thi…
preprints
2026
置信度 0.74
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This paper explores the mechanisms through which self-awareness and consciousness may arise in artificial intelligence (AI) systems. Drawing upon concepts from neuroscience, cognitive science, and embodied cognition, we propose that these phenomena can emerge …
preprints
2024
置信度 0.74
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Abstract The brain refines its predictions of the world by updating its internal model whenever sensory input differs from expectation. The sign of this prediction error matters: an unexpected event signals that the model under-predicted (positive error), whil…
preprints
2026
置信度 0.74
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Artificial intelligence is one of the fast-growing fields of science and technology. Exponential growth in AI has increased the number of AI content developers and users significantly, thereby impacting society and its functioning. This research is an attempt …
preprints
2024
置信度 0.74
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Abstract We present a customized OpenFlexure Microscope (OFM) platform for automated malaria diagnosis and parasitemia estimation. The system integrates a Laplacian-based autofocusing algorithm optimized for 100× oil immersion imaging and a YOLO-based deep lea…
preprints
2025
置信度 0.74