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• The interplay between tumor-intrinsic KRT6A and host-derived immune-nutritional status (PNI) defines prognosis in resectable PDAC.
  Current anatomic staging inadequately predicts outcomes in resectable pancreatic ductal adenocarcinoma (PDAC). This study integrates tumor-intrinsic KRT6A expression with host-derived prognostic nutritional index (PNI) to develop a novel prognostic model. This…
  pubmed Wang F, Yang X, Dai X, Lang R 等 2026 May 23 置信度 0.82
• Navigation-assisted surgery using an image-guided platform improves margin control and survival in advanced oral squamous cell carcinoma.
  Negative surgical margins are essential for curative resection in oral squamous cell carcinoma (OSCC), yet adequate clearance in very advanced tumors can be limited by complex craniofacial anatomy. This single-center retrospective cohort study screened 826 sur…
  pubmed Chao CW, Hsiao TH, Chiu SH, Liu CJ 2026 May 23 置信度 0.82
• A Systematic Evidence Map of FAIR Compliance in Open-Access Metabolomics Research: Results from a Pilot Study.
  Metabolomics is a powerful tool for precision health and biomarker discovery, yet the field faces persistent transparency and reproducibility challenges. The FAIR (Findable, Accessible, Interoperable, Reusable) Guiding Principles were established in 2016 with …
  pubmed Harrison C, Suchak T, Elomaa K, Zwiggelaar R 等 2026 May 21 置信度 0.82
• Genomic evolution and climate related drivers of cholera surges in Dhaka Bangladesh between 1996 and 2024.
  Cholera, a climate-associated diarrhea occurs endemically in Dhaka city, Bangladesh, often turning into large epidemics. In 2022, a massive outbreak struck Dhaka city, resulting in a very high number of cholera cases. Although extensive studies have focused on…
  pubmed Monir MM, Rahman K, Islam MT, Sultana M 等 2026 May 22 置信度 0.82
• Hippocampal volume for prediction of working memory performance in patients with infantile hydrocephalus.
  Infantile hydrocephalus is a common condition that requires surgery. However, cognitive outcomes following treatment are poorly understood, limiting the ability to prognosticate cognitive functioning or target cognitive therapies. Some studies have shown that …
  pubmed Ragguett RM, Meng L, Adil D, Eagleson R 等 2026 May 22 置信度 0.82
• U-CBAMNet: an attention-guided deep learning model for accurate and explainable prediction of HER2 expression from breast ultrasound cine videos.
  Accurate assessment of human epidermal growth factor receptor 2 (HER2) expression is essential for guiding targeted therapy in breast cancer. Conventional immunohistochemistry and fluorescence in situ hybridization remain the diagnostic standard but are invasi…
  pubmed Zhang Z, Tian C, Shi L, Zhou L 等 2026 May 21 置信度 0.82
• Prognostic significance of pretreatment (18)F-FDG PET/CT in hepatocellular carcinoma: A systematic review and meta-analysis.
  18 F-fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) is not routinely recommended for hepatocellular carcinoma (HCC) diagnosis or surveillance, and its prognostic role in patients with HCC remains unclear. This meta-analy…
  pubmed Min JH, Rezaee-Zavareh MS, Attia AM, Hwang SY 等 2026 Aug 置信度 0.82
• Updated trends in the global prevalence and burden of mental disorders, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
  The 2023 iteration of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) estimated prevalence, incidence, and health burden for 375 diseases and injuries, including 12 mental disorders. We assess past, current, and emerging trends in the pre…
  pubmed GBD 2023 Mental Disorder Collaborators 2026 May 23 置信度 0.82
• Non-canonical PPARα Agonism by Arjunolic Acid Mitigates Cardiomyocyte PANoptosis Through a Novel PPARα/CRYAB/IKKα Axis During Pathological Cardiac Hypertrophy.
  Pathological cardiac hypertrophy is manifested by downregulated PPARα driven metabolic dysregulation which culminates into cardiomyocyte apoptosis. Emerging evidences indicate that additional regulated cell death mechanisms also operate during cardiac pa…
  pubmed Kar A, Gupta S, Singh G, Matilal A 等 2026 May 20 置信度 0.82
• Integrative In Silico and Experimental Analysis Reveals MT1A and HSP70 as Components of a Dual Biomarker Axis for Heavy Metal Exposure.
  Heavy metal exposure in industrial environments constitutes a significant occupational health risk and can induce systemic oxidative and proteotoxic stress. In this study, in silico toxicogenomics was integrated with population-based validation to identify and…
  pubmed Singh S, Singh NK, Dwivedi N, Kumar D 等 2026 Sep 置信度 0.82
• Durable viral suppression in the dolutegravir era: a data-enabled, risk-stratified model for integrated HIV care in Uganda.
  Despite widespread rollout of dolutegravir-based (DTG) antiretroviral therapy (ART) in East Africa, viral non-suppression, advanced HIV disease (AHD), and multimorbidity persist, reflecting gaps in service response rather than regimen potency alone. In Uganda'…
  pubmed Namaganda MM, Nabende JN, Kateete DP, Batte C 等 2026 置信度 0.82
• MicroRNA Enrichment and Docking-Based Evaluation of Ilomastat Targeting of MMP-2 in Esophageal Squamous Cell Carcinoma: Insights from a South African Cohort.
  Introduction: MicroRNAs (miRNAs) play central roles in cancer pathogenesis by modulating oncogenic and tumor-suppressive pathways. The microRNA-29 (miR-29) family, known to inhibit matrix metalloproteinase-2 (MMP-2), represents a key regulatory axis in tumor i…
  pubmed Mbatha SZ, Alaouna M, Damane B, Marutha T 等 2026 置信度 0.82
• Novel molecular design via a scaffold-aware transformer with multi-scale attention mechanisms.
  Recent advancements in artificial intelligence have demonstrated enhanced potential in accelerating drug discovery by exploring vast chemical spaces and predicting molecular properties. In particular, scaffold-constrained molecular generation has enabled the i…
  pubmed Park J, Yoo S 2026 May 19 置信度 0.82
• Monkey jumping optimization: a tree-branch-inspired metaheuristic for global search.
  This paper presents Monkey Jumping Optimization (MJO), a novel nature-inspired metaheuristic algorithm that emulates the arboreal locomotion behavior of monkeys to address complex global optimization problems. The MJO algorithm integrates three biologically in…
  pubmed Dagal I, Dari YD 2026 May 19 置信度 0.82
• Estimating the within-herd transmission rate of highly pathogenic avian influenza H5N1 virus in a dairy herd using an approximate Bayesian computation approach.
  Since the initial detection in dairy herds in March 2024, highly pathogenic avian influenza (HPAI) H5N1 has spread extensively in the United States, with over 1,000 confirmed cases in dairy cattle across 17 states. Data on within-herd transmission of H5N1 are …
  pubmed Malladi S, Carestia A, Seys SA, Ssematimba A 等 2026 Sep 置信度 0.82
• Microenvironmental pH and host-pathogen co-evolution potentially influence the structural architecture of junctional adhesion molecules.
  Understanding how proteins dynamically adapt to diverse and changing physiological microenvironments is a fundamental challenge in modern biological sciences. Junctional adhesion molecules (JAMs) are a family of conserved proteins critically involved in immune…
  pubmed Karagöl T, Karagöl A 2026 May 19 置信度 0.82
• Emerging Frontiers in Prostate Cancer Diagnostics: Nanolaser-Guided Nanotechnology and Computational Biology for Biomarker Surveillance.
  Prostate cancer remains a leading cause of cancer-related mortality in men, with early and accurate diagnosis being crucial for effective management. This review explores the convergence of nanolaser- assisted nanotechnology and computational biology as innova…
  pubmed Chauhan SB, Singh I, Kalra Y, Jain C 2026 May 12 置信度 0.82
• From histology to spatial transcriptomics: establishing a lightweight single-patch baseline.
  Predicting spatial gene expression from hematoxylin and eosin (H&E)-stained histological images is a central challenge in the field of computational pathology. Although many models leverage the spatial context from entire whole-slide images to boost perfor…
  pubmed Jang H, Shin H, Lee H, Jang Y 等 2026 May 18 置信度 0.82
• Design, Synthesis, and Evaluation of Coumarin-Rasagiline Hybrids as Multifunctional Neuroprotective Agents.
  The design of hybrid molecules with multifunctional profiles has emerged as a promising strategy in medicinal chemistry, particularly for tackling complex disorders such as neurodegenerative diseases. There is an urgent need for therapeutic agents capable of a…
  pubmed Carneiro A, Barreiro S, Machado CS, Pinto M 等 2026 May 27 置信度 0.82
• Modeling Negative Symptom Domain Neurobiology: Protocol for an Observational, Transdiagnostic, Translational Study.
  Negative symptoms (NS) such as anhedonia (reduced pleasure), avolition (reduced motivation), asociality (social withdrawal), blunted affect (diminished emotional expression), and alogia (poverty of speech) are associated with poor functional outcomes in psychi…
  pubmed Oprea DC, Untu I, Vieru DS, Dascălu C 等 2026 May 18 置信度 0.82
• The speed limit of visual perception: Bidirectional influence of image memorability and processing speed on perceived duration and recognition.
  Visual stimuli are known to vary in their perceived duration, with some stimuli engendering so-called "time dilation" and others "time compression" effects, in which stimuli appear to last for relatively longer or shorter durations, respectively. Extant theori…
  pubmed Wiener M, Mondok C, Ma A, Desai C 等 2026 May 置信度 0.82
• GLP1-E2 therapy delays autoimmune diabetes in late-stage prediabetic NOD mice and potentiates low-dose anti-CD3 therapy for enhanced disease protection.
  Anti-CD3 monoclonal antibody (aCD3) delays progression to stage 3 type 1 diabetes in high-risk individuals by modulating autoimmune activity. Nevertheless, responses remain variable and transient, with therapy providing only indirect beta cell protection. We i…
  pubmed Degroote L, Chrzanowski J, Lemaitre P, Wouters A 等 2026 Aug 置信度 0.82
• Association of Qualitative Characters With Agronomic Traits, and Their Breeding Importance in Lentil (Lens culinaris Medikus).
  There is a paucity of available information on lentil ( Lens culinaris Medikus) qualitative traits and their associations with agronomic traits, despite such information being essential for the selection of best genotypes. Hence, this study was undertaken to e…
  pubmed Kefelegn N, Benor S, Haile G, Fikre A 等 2026 Jun 置信度 0.82
• Towards automated behaviour monitoring in wildlife: a review of machine learning approaches using accelerometer data.
  Monitoring animal behaviour provides critical insights into species ecology and offers essential information for guiding management and conservation efforts. Among the various approaches used to study behaviour, bio-logging-the use of animal-borne data recorde…
  pubmed Jeantet L, Oosthuizen WC, Chevallier D, Dufourq E 2026 置信度 0.82
• Sequential visual stimuli increase high frequency power in the visual cortex.
  Today, flickering full-field visual stimulation is used to increase neuronal oscillations for a variety of research or therapeutic purposes. We propose spatially organized sequential visual flickering stimulation as a newer tool to circumvent the intrinsic low…
  pubmed Keil J, Hernandez-Urbina V, Vassiliou C, Dean C 等 2026 May 17 置信度 0.82
• The role of whole genome sequencing in antimicrobial susceptibility prediction of bacteria: 2025 update from the European Committee on Antimicrobial Susceptibility Testing Subcommittee.
  The 2017 European Committee on Antimicrobial Susceptibility Testing (EUCAST) subcommittee report on the role of whole genome sequencing (WGS) in antimicrobial susceptibility testing (AST) concluded that WGS antimicrobial susceptibility prediction (WGS-ASP) was…
  pubmed Samuelsen Ø, López-Causapé C, Aarestrup FM, Bortolaia V 等 2026 Jun 置信度 0.82
• Associations between carotenoids and rheumatoid arthritis risk: evidence from two population-based studies.
  Carotenoids are common natural anti-inflammatory antioxidants produced by plants and some microorganisms. However, there are limited reports on the association between carotenoids and risk of rheumatoid arthritis (RA).
  pubmed Jing X, Lv M, Chen Y, Zhao X 等 2026 May 16 置信度 0.82
• Exploring the Lung-Liver Axis in Pulmonary Arterial Hypertension.
  The liver's contribution to pulmonary arterial hypertension (PAH) pathogenesis remains unclear. We hypothesized that the liver promotes inflammatory injury to the pulmonary endothelium. PAH patients without liver disease with pulmonary artery endothelial cell …
  pubmed Singh N, Lawson J, Ragavendran A, Banerjee S 等 2026 Jun 置信度 0.82
• 20 Years of the ISCB Student Council Symposium: shaping computational biology and future leaders.
  Over the past two decades, the Student Council Symposium (SCS), the flagship event of the ISCB Student Council, has grown into a vital forum for early-career researchers in computational biology. Since its inception in 2005, the SCS has served as a platform fo…
  pubmed Fernandez-Martin M, Castillo-Orozco A, Poley-Gil M, Pose-Lagoa I 等 2026 置信度 0.82
• Liver CT-based composite biomarkers can identify MASH and steatosis grade in people with obesity prior to bariatric surgery: a retrospective study.
  Hepatic steatosis is a precursor to metabolic dysfunction-associated steatohepatitis (MASH), which is linked to obesity and diabetes and poses a risk for liver cirrhosis and cancer. For detecting MASH and hepatic steatosis, liver biopsy is the reference method…
  pubmed Zhang H, Jiang Z, Zheng H, Wang H 等 2026 May 14 置信度 0.82
• Synchronous climbing fiber activity enables instructive signaling for cerebellar learning through modulation of disinhibitory circuits.
  Motor learning relies on signals that instruct adaptive plasticity following errors. In the cerebellum, climbing fibers (CFs) provide these instructions to Purkinje cells (PCs). Yet CFs fire continuously, even without errors, requiring molecular layer interneu…
  pubmed Park C, Yang Z, Nashef A, Gim J 等 2026 Jun 置信度 0.82
• Structurally diverse secondary metabolites from the dung-inhabiting fungus Botryotrichum murorum.
  A combination of confidence-aware MS/MS-based metabolomics and conventional chemical screening approaches was employed to investigate the metabolome of Botryotrichum murorum DSM 113281, isolated from tortoise dung. The metabolomic survey revealed a high degree…
  pubmed Charria-Girón E, Liu YY, Surup F, Marin-Felix Y 2026 May 14 置信度 0.82
• Rats develop more robust and persistent peritoneal adhesion phenotypes than mice: a multimodal comparative study.
  This study aimed to compare the differences between rat and mouse models of peritoneal adhesions (PAs). The cecum-abdominal wall ischemic injury suture method was used to establish postoperative PA models in Sprague-Dawley rats and BALB/c mice. Adhesion progre…
  pubmed Li J, Pu Z, Nian H, Ma S 等 2026 May 14 置信度 0.82
• Genomics of MTAP Loss in >500,000 Solid Tumor Specimens Profiled Using Comprehensive Genomic Profiling Platforms.
  Methylthioadenosine phosphorylase ( MTAP ) genomic loss is an emerging biomarker for PRMT5 and MAT2A inhibitors based on synthetic lethality. The MTAP gene is located on chromosome 9p21.3 near CDKN2A/B. MTAP homozygous loss across tumor types, specific exons l…
  pubmed Pavlick DC, Rengarajan S, Lee JK, Jin DX 等 2026 May 置信度 0.82
• [Endoscopic diagnosis of neurogenic dysphagia and quantitative visual scale assessment of posterior sialorrhea for the prevention of aspiration events in adults].
  This study aimed to evaluate the efficacy and safety of intrasalivary injections of incobotulinumtoxinA for the prevention of aspiration complications in patients with neurogenic dysphagia and posterior sialorrhea of various etiologies.
  pubmed Khatkova SE, Pogoreltseva OA, Baturova VY, Agafonov SS 等 2026 置信度 0.82
• Molecular imaging of atherosclerotic plaque vulnerability: a narrative review.
  Atherosclerotic plaque rupture or erosion underlies most acute coronary and cerebrovascular events. Risk stratification currently relies on luminal stenosis, which poorly predicts thrombotic risk because many events arise from biologically vulnerable plaques w…
  pubmed To V, Ha J 2026 May 14 置信度 0.82
• CEDR: robust consensus cancer subtyping with multi-omics data via ensemble dimensionality reduction.
  Cancer is a highly heterogeneous disease underpinned by complex molecular alterations. Accurate subtyping is critical for guiding personalized treatment and improving clinical outcomes. However, multi-omics data are high-dimensional, noisy, and heterogeneous a…
  pubmed Cao H, Xu Z, Lin S, Du G 等 2026 May 4 置信度 0.82
• APE1 coordinates its disordered region and metal cofactors to drive genome surveillance.
  Efficient recognition of DNA lesions such as apurinic/apyrimidinic (AP) sites is essential for maintaining genome stability. Apurinic/apyrimidinic endonuclease 1 (APE1) is the primary eukaryotic AP endonuclease, yet how it identifies rare lesions among vast st…
  pubmed Lee D, Kim S, Jo G, Kim J 等 2026 May 5 置信度 0.82
• Repurposing the angiotensin II receptor blocker valsartan to inhibit penicillin-binding protein 3 and its mutants in Haemophilus influenzae: a comprehensive in silico approach.
  Ampicillin-resistant Haemophilus influenzae ( H. influenzae ) has been recently designated as a medium-priority bacterial pathogen in 2024 by the World Health Organization (WHO). This pathogen is responsible for a wide range of infections, including sinusitis,…
  pubmed Kacha S, Arun J, Nargund N, Joshi T 等 2026 置信度 0.82
• A long-term photographic dataset for individual identification of the Balearic wall lizard.
  We present BalearicLizard , a curated, long-term collection of high-resolution photographs of the Balearic wall lizard (Podarcis lilfordi) designed to support non-invasive individual re-identification, ecological monitoring and computer-vision benchmarking. Th…
  pubmed Alcaraz R, Albalat-Oliver B, Villa A, Tavecchia G 等 2026 May 13 置信度 0.82
• Extensive cryptic circulation sustains mpox among men who have sex with men.
  Sporadic cases of clade IIb mpox continue to be notified among men who have sex with men, with most lacking identifiable transmission links. To resolve underlying dynamics, we tested prospectively for evidence of monkeypox virus infection in anorectal swabs fr…
  pubmed Lewnard JA, Paredes MI, Yechezkel M, Davis GS 等 2026 May 13 置信度 0.82
• Recent Geant4 developments and applications in medicine and biology: Report from the 5th Geant4 International User Conference at the Physics-Medicine-Biology Frontier.
  The Geant4 International User Conference at the Physics-Medicine-Biology Frontier is a conference series for Geant4 and Geant4-DNA users working in medical physics, radiation protection from environmental and space radiation, radiation biology, and related fie…
  pubmed Sakata D, Guatelli S, Sasaki T, Brown JMC 等 2026 Jun 置信度 0.82
• Hydrological dynamics of a Mediterranean water drain network: Implications for Aedes albopictus surveillance and population growth control.
  Water drains act as cryptic but prolific mosquito larval habitats and are often the most productive breeding sites in urban landscapes. Understanding how climate and water infrastructures interact to shape these breeding habitats is essential for controlling v…
  pubmed Bellver-Arnau J, Blanco-Sierra L, Escartin S, Bernal S 等 2026 May 15 置信度 0.82
• Passive acoustic monitoring captures spatiotemporal dynamics of urban zoo soundscapes.
  Urban zoos are important but complex artificial ecosystems that integrate wildlife conservation with public education. Their soundscapes, including anthrophony, biophony, and geophony, show significant spatiotemporal dynamics. Persistent fluctuations could con…
  pubmed Li X, Zhang W, Tian S, Wang Z 等 2026 May 15 置信度 0.82
• Detection, persistence, and rising prevalence of oncogenic viruses revealed by wastewater metagenomics.
  Oncogenic viruses cause high-risk cancers in humans and are responsible for nearly 20% of all cancer cases worldwide. Currently, very limited data exist in the realm of wastewater-based viral epidemiology (WBE) for cancer-causing viruses, with existing studies…
  pubmed Prakash H, Perez RK, Ross M, Tisza M 等 2026 Jun 17 置信度 0.82
• Severe Neurovascular and Cardiovascular Manifestations of Takayasu Arteritis: A Case Series and Review of the Literature.
  Takayasu arteritis is a chronic large-vessel vasculitis that predominantly affects young women and may lead to severe vascular complications. This case series is noteworthy because it describes Takayasu arteritis revealed by severe cardiovascular and neurovasc…
  pubmed Said IsmaIl AA, Moyambi J, Afendi L, Haboub M 等 2026 May 置信度 0.82
• Dynamic, Unconstrained Optimization of Secreted Enzyme Production in Fed-Batch Fermentation Using Reinforcement Learning.
  Reinforcement learning (RL) has been used to control a wide range of dynamic processes, especially ones that are too complex to model well or have stochastic environmental perturbations. Fed-batch fermentations are subject to changes in starting cell growth ra…
  pubmed Uthravalli SH, Ferdous S, Hess JM, Reuel NF 2026 Aug 置信度 0.82
• Allergenicity Assessment of Plant-Derived Sweet Proteins-In Silico, In Vitro, In Vivo, and Clinical Approach: A Systematic Review.
  Plant-derived sweet proteins are promising low-calorie natural sweeteners that may reduce dietary sugar intake and prevent non-communicable diseases. Although seven have been identified-thaumatin, miraculin, monellin, mabinlin, brazzein, pentadin, and curculin…
  pubmed Hidayati R, Giriwono PE, Saraswati, Andarwulan N 等 2026 Apr 25 置信度 0.82
• A Review and Experimental Analysis of Supervised Learning Systems and Methods for Protein-Protein Interaction Detection.
  The exponential growth of genomic and proteomic data has made computational protein-protein interaction (PPI) prediction indispensable, driving the need for a comprehensive and method-aware evaluation of supervised learning approaches. PPIs are fundamental to …
  pubmed Taha K 2026 May 2 置信度 0.82
• Assessing a biomarker platform for stratifying indeterminate pulmonary nodules, protocol for the SPOT IT randomized trial.
  Millions of lung nodules are detected every year during routine computed tomography imaging. While most are benign, some represent early-stage lung cancer and require prompt diagnosis as survival worsens with advanced stages. The Lung Cancer Prediction score i…
  pubmed Paez R, Khalil TA, Forero Y, Woodhouse P 等 2026 May 12 置信度 0.82
• CT-detected lymphadenopathy and prognostic markers in severe fever with thrombocytopenia syndrome: a retrospective study.
  Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne viral disease with substantial mortality in endemic regions. CT findings, particularly lymphadenopathy with perinodal fat stranding, may be under-recognized. We evaluated CT findings and factor…
  pubmed Homma Y, Katsuta T, Inoue T, Fukumori Y 等 2026 May 12 置信度 0.82
• Optimal dosing for vascular anomalies paediatric patients with population pharmacokinetic model of sirolimus.
  Sirolimus is currently used off-label for paediatric patients with vascular anomalies. However, the optimal dosage regimen for paediatric patients remains controversial. This study aimed to determine the optimal dosing regimen of sirolimus in these patients us…
  pubmed Jeong S, Kim J, Jung W, Jeon J 等 2026 Sep 置信度 0.82
• Clinical Course and Risk Factors for Malignant Progression in Intraductal Papillary Mucinous Neoplasms with High-Risk Stigmata.
  Surgical resection is recommended for intraductal papillary mucinous neoplasms (IPMN) with high-risk stigmata (HRS). However, in clinical practice, some patients are managed conservatively because of their advanced age or comorbidities. We aimed to evaluate th…
  pubmed Hasegawa S, Kurita Y, Yamazaki Y, Honda Y 等 2026 Aug 置信度 0.82
• An Agent-Based Cellular Automaton Platform for Simulating Climate-Driven Mosquito Vector Spread in Alpine Regions.
  Climate change is expanding the suitable habitat range for mosquito species into previously uninhabitable alpine regions, necessitating tools for projecting vector establishment risk.
  pubmed Schweitzer M, Schwaiger A, Taha H, Pfeifer B 2026 May 7 置信度 0.82
• Synergistic Short-Term Synaptic Plasticity Mechanisms for Working Memory.
  Working memory (WM) is essential for almost every cognitive task. The neural and synaptic mechanisms supporting the rapid encoding and maintenance of memories in diverse tasks are the subject of an ongoing debate. The traditional view of WM as stationary persi…
  pubmed Fiebig F, Chrysanthisdis N, Lansner A, Herman P 2026 Aug 1 置信度 0.82
• A standardized and efficient intensity-based image registration framework for quantitative cranial base superimposition.
  Structural cranial base superimposition is widely regarded as a biologically reliable reference for evaluating orthodontic treatment outcomes. However, its clinical implementation remains limited due to labor-intensive manual procedures and operator-dependent …
  pubmed Wang F, Lyu Y 2026 May 12 置信度 0.82
• SAASI: Sampling Aware Ancestral State Inference.
  In phylogeography, ancestral state inference methods are used to identify the geographic or host species origin of viral or bacterial lineages and reconstruct their transmission histories over time. However, differences in sampling among states can bias these …
  pubmed Song Y, Gill I, MacPherson A, Colijn C 2026 May 11 置信度 0.82
• Stress-Based biomechanical modeling in hip dysplasia Surgery: A scoping review.
  Stress-based biomechanical modeling is increasingly used to evaluate joint mechanics and support surgical planning in developmental dysplasia of the hip (DDH). This scoping review examines how such models are applied in DDH surgery, the mechanical insights the…
  pubmed Amoakon REVI, Seguin AA, Belzile EL, Awada Z 等 2026 Jul 置信度 0.82
• Kernel-smoothed permutation for extreme P-value estimation in genetic association studies.
  In genetic association studies, permutation tests serve as a cornerstone to estimate P-values. This is because researchers may design new test statistics without a known closed-form distribution, or the assumption of a well-established test may not hold. Howev…
  pubmed Bian J, Wu J, Ethan MacDonald M, Wu L 等 2026 Jul 6 置信度 0.82
• Mapping the Knowledge Landscape of Muscle Disorders in Rheumatoid Arthritis: A Bibliometric and Bioinformatics Study.
  This study conducted a bibliometric analysis of publications related to the comorbidity between rheumatoid arthritis (RA) and Muscle Disorders, sourced from the Web of Science Core Collection database between January 1, 2015, and December 31, 2024. By examinin…
  pubmed Ma L, Yao T, Jin D, Yan Z 2026 Apr 21 置信度 0.82
• The neuroprotective potential of diosgenin: an integrated in silico, in vitro, and in vivo approach in colchicine-induced Alzheimer's model.
  Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with memory loss, spatial disorientation, and a marked decline in cognitive capacity. Colchicine, a microtubule-disrupting agent, is widely used to model cognitive dysfunction in a…
  pubmed S T, Dwivedi PSR, Mole SS, U N 等 2026 May 11 置信度 0.82
• Immune Spatial Organization Predicts Distant Metastasis Risk in Aggressive Localized Prostate Cancer.
  Computational pathology has emerged as an attractive option for improving risk stratification in prostate cancer, but most approaches either lack interpretability or focus solely on tumor morphology. We aimed to identify an interpretable, immune microenvironme…
  pubmed Yang DD, Abdelnaser A, Haas AJ, Wala J 等 2026 Aug 14 置信度 0.82
• Bacteriological Profile and Antibiotic Resistance Patterns of Wastewater Effluents in 2 Hospitals of Ethiopia.
  The wastewater effluent is a hotspot for a multitude of microorganisms, including environmental pathogens, true human pathogens, and animal pathogens. In the absence of standardized wastewater treatment facilities, these pathogens contaminate surface and groun…
  pubmed Derso BM, Kassa BA, Abate TA, Birhanu AG 等 2026 置信度 0.82
• Accessibility in proteins and RNAs interactions prediction with machine learning: are we overlooking non-experts?
  The increasing growth in the volume of biomolecular data has introduced significant challenges for extracting meaningful molecular-level insights, particularly in predicting interactions between biological sequences such as DNA, RNA, and proteins. These intera…
  pubmed Florentino BR, Bonidia RP, F de Carvalho ACPL 2026 May 4 置信度 0.82
• Toward trustworthy artificial intelligence in multi-omics: a review of reproducibility, stability, and interpretability.
  The integration of multi-omics data has become increasingly important in advancing precision medicine and systems biology. However, the reliability and trustworthiness of artificial intelligence (AI) models applied to such data remain critical concerns. This r…
  pubmed Vo TH, Le NQK 2026 May 4 置信度 0.82
• Metastatic Meningioma with Systemic Involvement: Discussion of Molecular, Genomic, and Radiological Features.
  Meningiomas are typically benign, slow-growing tumors localized to the cranial or spinal regions, with less than 1% metastasizing systemically, posing a serious clinical challenge. This case series adds critically needed data to broaden existing knowledge and …
  pubmed Sulman M, Del Bosque A, Cantillo D, Aboubechara JP 等 2026 Jul 置信度 0.82
• Pharmacological markers of HIV prevention for oral pre-exposure prophylaxis in men who have sex with men.
  The human immunodeficiency virus (HIV) infected approximately 1.1 million individuals in 2024. There is no effective vaccine or cure, and funding cuts in resource-limited settings threaten treatment access. Cost-effective and widely available prevention strate…
  pubmed Iannuzzi S, Müller M, Yu Y, Zhang L 等 2026 May 10 置信度 0.82
• Immunogenicity, reactogenicity, and safety of a reduced-interval 4CMenB primary immunisation schedule in UK infants: a multicentre, open-label, assessor-blinded, phase 4 randomised controlled trial.
  Until July, 2025, infants in the UK received the four-component meningococcal B vaccine (4CMenB) at ages 8 weeks and 16 weeks, boosted at 1 year. 4CMenB introduction was associated with large reductions in serogroup B (MenB) invasive meningococcal disease in c…
  pubmed Thorn N, Danos Z, Andrews NJ, Sutton N 等 2026 Aug 置信度 0.82
• AI-predicted spatial transcriptomics unlocks breast cancer biomarkers from pathology.
  Spatial transcriptomics (ST) assays are transforming our understanding of tumor heterogeneity, but their high cost limits their application in large-scale biomarker discovery. Here, we present "Path2Space," a deep-learning model that predicts spatial gene expr…
  pubmed Shulman ED, Campagnolo EM, Lodha R, Chung Y 等 2026 Jul 9 置信度 0.82
• Exploring Thoracic Radiotherapy in Metastatic NSCLC: A Retrospective Review in the Era of Immunotherapy and Targeted Therapies.
  Lung cancer remains the leading cause of cancer-related deaths worldwide. Advances in immunotherapy and targeted therapies have improved survival in stage IV non-small cell lung cancer (NSCLC), highlighting the importance of local control of the primary tumor.…
  pubmed Mansoorian S, Lehmann J, Käsmann L, Gaus R 等 2026 May 置信度 0.82
• Proteomic analysis in Alzheimer's disease and other dementias: a focus on sex-specific differences.
  Fluid protein studies in cerebrospinal fluid (CSF) and plasma have provided important insights into neurodegenerative dementias; however, there is a limited investigation of sex-related differences and cross-biofluid relationships. In Alzheimer's disease (AD),…
  pubmed Comas-Albertí A, Lladó A, Esteller-Gauxax D, Borrego-Écija S 等 2026 May 8 置信度 0.82
• Machine learning-based integration of transcriptome and digital pathology for predicting chemoresistance in muscle-invasive bladder cancer.
  Muscle-invasive bladder cancer (MIBC) presents with variable clinical and pathological features, leading to inconsistent responses to standard treatments such as neoadjuvant chemotherapy (NAC). Although transcriptome profiling has shown differences in NAC resp…
  pubmed Jeong J, Jeong G, Kim Y, Ju H 等 2026 May 置信度 0.82
• Learning brain dynamics across distinct scaling regimes reveals psychiatric signatures.
  Understanding how the brain's nonlinear dynamics give rise to cognition remains a central challenge in neuroscience. Conventional neuroimaging methods assume linearity and stationarity, failing to capture frequency-specific neural computations. We introduce Mu…
  pubmed Bae S, Kwon J, Yoo S, Cha J 2026 May 8 置信度 0.82
• CellXpress.ai: Machine learning powered system for automation of complex 2D and 3D cell culture workflows.
  Attrition in the therapeutic pipeline can often be attributed to a lack of translational efficacy from pre-clinical to clinical phases. Organoids show great promise as a game-changer in disease modeling and drug screening, as they better resemble tissue struct…
  pubmed Sirenko O, Michlmayr A, Macha P, Grund-Gröschke S 等 2026 Jul 置信度 0.82
• Important progress in antimicrobial peptide prediction research in the past five years.
  Antimicrobial peptides (AMPs), as key targets for novel anti-infection therapy, have made their efficient and precise identification technology a critical breakthrough in biomedical research. Currently, the high cost of experimental validation severely restric…
  pubmed Zuo Y, Liu X, Shao X, Guo Z 等 2026 Sep 置信度 0.82
• Understanding Vaccine Hesitancy in Louisiana Through Social Media Listening and Community Feedback: Cross-Sectional Study.
  The rise of social media has significantly impacted public health programs, with platforms such as YouTube, Facebook, X (formerly known as Twitter), Instagram, and, more recently, TikTok being used to promote health information, raise awareness about disease o…
  pubmed Sanchez AV, Smith S, Sakhamuri S, Ardoin J 等 2026 May 6 置信度 0.82
• Towards a context-aware framework for cellular senescence.
  From a cellular perspective, senescence has been considered a binary state, wherein cells are either senescent or not. This reductionist notion, often defined as irreversible growth arrest, has guided efforts to identify universal biomarkers and…
  pubmed Nath A, Mehrotra P, Bhattacharyya C, Saini DK 2026 May 6 置信度 0.82
• Characterization of Genetic Etiologic Factors for Pediatric Acute Lymphoblastic Leukemia in Large Childhood Cancer Survivorship Cohorts.
  Germline genetic susceptibility to pediatric acute lymphoblastic leukemia (pALL) remains incompletely characterized across the allelic spectrum, including ultrarare, high-penetrance cancer-predisposing variants (CPV).
  pubmed Meng X, Chen C, Qin N, Mulder HL 等 2026 Jul 1 置信度 0.82
• Wafer-Scale 2D High-Entropy Transition Metal Dichalcogenide Thin-Film Catalysts for Efficient and Durable Photoelectrochemical Hydrogen Production.
  Photoelectrochemical (PEC) performance of conventional 2D transition metal dichalcogenides (TMDs) in hydrogen evolution reaction (HER) is constrained by the limited selection of metal cations, predominantly MoS 2 , whose inert basal planes and unstable 1T phas…
  pubmed Jun SE, Seo JH, Kim J, Lee H 等 2026 Jun 置信度 0.82
• Synaptic high-frequency jumping synchronises vision to high-speed behaviour.
  During high-speed behaviour, animals must synchronise perception and action despite rapid environmental and self-generated motion. How neural systems achieve such precision remains unclear. Here we show how the housefly (Musca domestica) maintains visual accur…
  pubmed Mansour N, Takalo J, Kemppainen J, Bridges AD 等 2026 May 5 置信度 0.82
• Retraction notice to "The experimental significance of isorhamnetin as an effective therapeutic option for cancer: A comprehensive analysis" [Biomedicine & Pharmacotherapy 176 (2024) 116860].
  pubmed Biswas P, Kaium MA, Tareq MMI, Tauhida SJ 等 2026 Jun 置信度 0.82
• Service Users' Views on Digital Remote Monitoring for Psychosis: Survey Study.
  Digital remote monitoring using smartphones and wearable devices is a promising solution for psychosis management, where precise, time-sensitive intervention is crucial. Combining active symptom monitoring (ASM) and passive sensing (PS) can support self-manage…
  pubmed Zhang X, Eisner E, Di Basilio D, Richardson C 等 2026 May 5 置信度 0.82
• Application of machine learning with MALDI-TOF MS for rapid differentiation between methicillin-susceptible and methicillin-resistant Staphylococcus aureus.
  Application of machine learning with matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry may allow rapid differentiation between methicillin-susceptible (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA) and enab…
  pubmed Lin YS, Wong RC, Yu J, Yang K 等 2026 May 置信度 0.82
• Real-Life Evaluation of the Revised IWOS, Modified Abad and SUN Criteria in a Multicenter Cohort of 409 Patients with Sarcoid Uveitis.
  To evaluate and compare the International Workshop on Ocular Sarcoidosis (IWOS) revised diagnostic criteria, the modified Abad diagnostic criteria, and the Standardization of Uveitis Nomenclature (SUN) classification criteria in patients with sarcoid uveitis i…
  pubmed Cargnelutti M, Jacquot R, El-Jammal T, Siriphanh A 等 2026 Jul 置信度 0.82
• CFD Modeling of Airflow and Aerosol Transport in the Human Respiratory System: A Comprehensive Review.
  Accurate modelling of airflow and aerosol/particle dynamics within the human respiratory system is essential for improving inhalation-based drug delivery strategies and for evaluating the health risks associated with hazardous particulates. Owing to the comple…
  pubmed Ciloglu D, Ucuncu H 2026 May 置信度 0.82
• Exploring morphological traits related to potential milling yield based on image-analysis.
  Wheat (Triticum aestivum L.) is a globally essential cereal crop whose productivity and processing efficiency are critically influenced by the morphological traits of the grain. While biotic and abiotic stresses reduce field yields, post-harvest milling losses…
  pubmed Le AT, Park JE, Thai TT, Park SY 等 2026 May 4 置信度 0.82
• Tissue-Level Neck Response in Rotary-Wing Aircrew With Head-Supported Mass Assessed With Finite Element Model.
  Epidemiological studies have reported a prevalence of neck pain among rotary-wing aircrew (RWA), attributed in part to head-supported mass (HSM) including helmet and night vision goggles (NVG). Combined HSM and movement of the head away from the neutral positi…
  pubmed Hadagali P, Fischer SL, Callaghan JP, Cronin DS 2026 May 置信度 0.82
• Recommendations made and accepted by a telehealth-enabled Antimicrobial Stewardship program implemented at rural veterans affairs medical centers.
  To support Antimicrobial Stewardship programs (ASPs) as well as the clinical care of patients with infections, we disseminated and implemented a Videoconference Antimicrobial Stewardship Team (VAST) to connect multidisciplinary teams from rural Veterans Affair…
  pubmed Bej TA, Milner AL, Nguyen A, Vivo A 等 2026 May 4 置信度 0.82
• Computational Investigation of Novel pUL56 Ligands Using Docking and Molecular Dynamics with Preliminary Cytotoxicity Evaluation: An Early-Stage Study.
  Human cytomegalovirus (HCMV) remains a significant cause of morbidity in immunocompromised patients, necessitating the development of improved antivirals. Using an integrated in silico and in vitro approach, we identified a novel ligand (NL) as a letermovir an…
  pubmed Feoktistova V, Afolabi SO, Klabukov AM, Shtro AA 等 2026 Apr 17 置信度 0.82
• Pangenome Architecture and Accessory Gene-Driven Population Structure of Staphylococcus aureus Revealed by a Hospital-Adjacent Environmental Isolate.
  Staphylococcus aureus is a globally distributed bacterium that spans interconnected human, animal, and environmental niches and is a major driver of antimicrobial resistance. Environmental and wildlife-associated isolates from hospital-surrounding settings rem…
  pubmed Rodrigues WF, Mazurek L, Miguel RB, Vilela GP 等 2026 Apr 21 置信度 0.82
• Overview of Short Peptides for Hair Loss.
  Hair serves essential functions, including mechanical sensing, head protection, and body temperature regulation, while also playing a significant role in human aesthetics. However, factors such as hormonal imbalances, autoimmune disorders, infections, and psyc…
  pubmed Fan C, Chen Y, Huang Q, Ou WY 等 2026 Apr 9 置信度 0.82
• A Low-Cost Laser Interferometric Elastography System for Skin Elasticity Measurement.
  This paper introduces a laser interferometric elastography (LIE) system that uses a narrow linewidth laser and a single photodetector to measure mechanical displacements induced by surface acoustic waves (SAWs) generated by an electrically driven piezoelectric…
  pubmed Parmar A, Chauhan S, Alghziwatalkhawaldh S, Singh K 2026 Apr 10 置信度 0.82
• Histological Study of a Novel 3D-Printed Hydroxyapatite/PLGA Bone Graft in the Regeneration of Critical-Sized Long Bone Defects.
  Critical-sized bone defects pose significant challenges in orthopedic surgery. The introduction of 3D printing technology in bone grafting offers a promising solution by creating customized grafts that mimic the natural bone structure. This study aimed to reco…
  pubmed Bajić MP, Paraš S, Mićić M, Petrović B 等 2026 Mar 28 置信度 0.82
• Correction: Li et al. Improved Chinese Giant Salamander Parental Care Behavior Detection Based on YOLOv8. Animals 2024, 14, 2089.
  In the original publication [...].
  pubmed Li Z, Luo S, Xiang J, Chen Y 等 2026 Apr 15 置信度 0.82
• Development and external validation of an interpretable multimodal deep learning model for 5-year mortality in high-risk stage ii colorectal cancer.
  High-risk stage II colorectal cancer (CRC) shows heterogeneous outcomes despite adjuvant chemotherapy. We developed and validated an interpretable multimodal deep learning model integrating clinical data, serum biomarkers, and venous-phase CT to predict 5-year…
  pubmed Li X, Liang L, Liu ZH, Wang C 等 2026 May 2 置信度 0.82
• Fate of proximal anastomosis after aortic repair for acute aortic dissection.
  This study aimed to investigate events related to proximal anastomosis after acute aortic dissection surgery.
  pubmed Sugiyama K, Watanuki H, Tochii M, Matsuyama K 2026 May 2 置信度 0.82
• Childhood adversity and adolescent motherhood: A cross-sectional study of trauma, partner age gaps, and parenting in the Dominican Republic.
  Adolescent pregnancy is increasingly understood as closely associated with pre-existing disadvantage, yet critical gaps remain regarding which adverse childhood experiences (ACEs) are associated with early childbearing, partner characteristics, and parenting t…
  pubmed Castro A, Sánchez-Vincitore LV 2026 Jul 置信度 0.82
• Class-level DILI saturation and hERG-driven risk stratification among 2024-2025 FDA-approved kinase inhibitors: an in silico multi-platform safety analysis.
  Newly approved kinase inhibitors (2024-2025) have limited post-approval safety data. We developed a weighted ToxPi framework to prioritize multi-endpoint liabilities spanning hERG cardiotoxicity, DILI, Ames genotoxicity, and CYP3A4-mediated drug-drug interacti…
  pubmed Küçük Yılmaz N, Baskın V 2026 Jun 置信度 0.82
• Real-World Impact of a National Funding-Driven Transition Between Automated Insulin Delivery Systems in Pediatric Type 1 Diabetes.
  In October 2024, New Zealand's pharmaceutical funding agency (PHARMAC) introduced fully funded access to Tandem t:slim X2 and Ypsomed YpsoPump insulin pumps, alongside Abbott and Dexcom continuous glucose monitoring (CGM). As Medtronic CGM remained unfunded, c…
  pubmed Walker M, Thomas A, Allison H, Ferguson J 等 2026 May 2 置信度 0.82
• Fecal HBA mRNA as an alternative to FIT for colorectal cancer screening: a computational and clinical validation study.
  Current US FDA-cleared stool-based colorectal cancer (CRC) molecular screening tests include fecal immunochemical tests (FIT) for occult blood detection; however, integration with nucleic acid-based biomarkers requires separate workflows, thereby increasing co…
  pubmed Pan W, Hansen L, Lin H, Song C 等 2026 May 1 置信度 0.82