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Early detection of oral squamous cell carcinoma (OSCC) significantly enhances treatment outcomes and survival rates, with lymph node metastasis serving as a main prognostic factor. However, current clinical practices rely on TNM classification, including histo…
europepmc
2025
置信度 0.80
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Environmental contamination is becoming an increasingly evident risk to human health worldwide. The small, free-living nematode Caenorhabditis elegans ( C. elegans ) has become a compelling model organism for environmental toxicity studies in recent years, owi…
europepmc
2025
置信度 0.80
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Improving the specificity of biosensors by reducing their false positive rate is a long-standing challenge, particularly for point-of-care (POC) diagnostics. An emerging and potentially impactful class of POC biosensor is those that can detect specific nucleic…
europepmc
2026
置信度 0.80
-
Synthetic multicellular systems have great potential for performing complex tasks, including multi-signal detection and computation through cell-to-cell communication. However, engineering these systems is challenging, requiring precise control over the cell c…
europepmc
2025
置信度 0.80
-
Graphene-based nanomaterials have attracted significant attention for their potentials in biomedical and biotechnology applications in recent years, owing to the outstanding physical and chemical properties. However, the interaction mechanism and impact on bio…
europepmc
2024
置信度 0.80
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The development of high-performance functional biointerfaces requires precise control over molecular recognition mechanisms at the nanoscale. A fundamental limitation in current biological nanopore materials is that wild-type (WT) channels often lack the speci…
europepmc
2026
置信度 0.80
-
A major challenge in addressing global health issues is developing simple, affordable biosensors with high sensitivity and specificity. Significant progress has been made in at-home medical detection kits, especially during the COVID-19 pandemic. Here, we demo…
europepmc
2025
置信度 0.80
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The developmental competence of oocytes is a critical limiting factor in bovine in vitro embryo production (IVEP). Our study aimed to investigate the relationship between the intrafollicular concentrations of interleukin-10 (IL-10) and progesterone (P4), folli…
europepmc
2025
置信度 0.80
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operon in 1961 by Jacob and Monod, transcriptional regulation in prokaryotes has been studied extensively and has led to the development of transcription factor-based biosensors. Due to the broad variety of detectable small molecules and their various applicat…
europepmc
Brecht De Paepe, Marjan De Mey
2024-12-22
置信度 0.80
Computational biologyTranscription factorSynthetic biologyComputer scienceBiology
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This paper proposes a multi-party verifiably collaborative system for encrypting the nonlinear and the non-stationary biomedical signals captured by biomedical sensors via the singular spectrum analysis (SSA)-based chaotic networks. In particular, the raw sign…
europepmc
2025
置信度 0.80
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In recent years, monoelemental 2D materials (Xenes) such as graphene, graphdiyne, silicene, phosphorene, and tellurene, have gained significant traction in biosensing applications. Owing to their ultra-thin layered structure, exceptionally high specific surfac…
europepmc
2025
置信度 0.80
-
Surface-enhanced Raman scattering (SERS) offers a powerful route for biomolecular detection because it combines molecular specificity with high sensitivity, rapid optical readout, and multiplexing capability. In real biological samples, however, analytical per…
europepmc
2026
置信度 0.80
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This paper presents a new biosensor design based on the Kretschmann configuration, for the detection of analytes at different refractive indices. Our studied design consists of a TiO 2 /SiO 2 bi-layer sandwiched between a BK7 prism and a bimetallic layer of Ag…
europepmc
2024
置信度 0.80
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Specificity in membrane trafficking relies on the interaction between Rab small GTPase proteins and their molecular effectors. However, the evidence that different Rab proteins can bind to common effectors challenges this view. Here, we show that molecular com…
europepmc
2025
置信度 0.80
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Telerehabilitation-the remote delivery of rehabilitation services-is undergoing a paradigm shift with the convergence of immersive virtual reality (VR) and wearable biosensor technologies. This perspective article outlines a vision for home-based motor and cog…
europepmc
2026
置信度 0.80
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europepmc
2025
置信度 0.80
-
Analytical tools may revolutionize healthcare by enabling accessible, rapid, and decentralized testing. Wearable (bio)sensors, in particular, provide frequent or continuous patient monitoring through non- to minimally invasive measurements. This approach yield…
pubmed
Brazaca LC, Moreno Lozano A, Mayol B, Scheidt DT 等
2026
置信度 0.82
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Interest in non-canonical DNA structures continues to grow, in part fueled by the recent discovery of a new structure, G-triplex DNA. Originally proposed as folding intermediates for G-quadruplex DNA, G-triplex DNA has more recently been shown to form from tru…
europepmc
2025
置信度 0.80
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RNA devices, including riboswitches, aptazymes, and RNA-based biosensors, have become essential components in synthetic and molecular biology. These systems make use of RNA's modularity and structural diversity to build programmable tools for sensing, regulati…
europepmc
2026
置信度 0.80
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Parkinson's disease (PD), a neurodegenerative disorder marked by the progressive loss of dopaminergic neurons in the substantia nigra, imposes substantial economic burdens, including both direct and indirect costs. The medical community currently lacks a defin…
europepmc
2025
置信度 0.80
-
While surface plasmon resonance (SPR) sensors serve as vital tools for biomolecular detection; conventional versions suffer from inherent limitations, including confined localized electromagnetic fields and inadequate sensitivity for detecting low-abundance an…
europepmc
2025
置信度 0.80
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Recent advances in computational tools, particularly machine learning (ML), deep learning (DL), and structure-based modeling, are transforming aptamer research by accelerating discovery and enhancing biosensor development. This review synthesizes progress in p…
europepmc
2025
置信度 0.80
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'Light-up' aptamers are short oligonucleotides that can induce fluorescence of certain organic compounds upon binding. In this study, we compared three crystal violet (CV) aptamers-CV30S, parallel G-quadruplex (G4), and antiparallel G4-regarding their absolute…
europepmc
2025
置信度 0.80
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High rates of missing data in wearable sensor streams hinder early detection of infectious diseases, especially in low-resource settings with inconsistent device adherence and connectivity. We developed a lightweight generative adversarial network (GAN) framew…
europepmc
2026
置信度 0.80
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Gradients negatively affect performance in large-scale bioreactors; however, they are difficult to predict at laboratory scale. Dynamic microfluidics single-cell cultivation (dMSCC) has emerged as an important tool for investigating cell behavior in rapidly ch…
europepmc
2025
置信度 0.80
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The application of antibody therapeutics is promising in the field of immunotherapy. While, heterologization should be done in most cases before applying the therapeutic antibodies into bodies, e.g., humanization, caninization and felinization for human beings…
europepmc
2024
置信度 0.80
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Investigating molecular interactions is crucial for advancing biological research and therapeutic discovery. Traditional analytical techniques often face limitations in sensitivity, quantification accuracy, and simplicity. Metasurfaces support resonances that …
europepmc
2025
置信度 0.80
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Rapid protein detection is crucial for medical diagnosis, clinical trials, and drug development but often faces challenges in balancing sensitivity with multiplex detection, low reagent consumption, and a short detection time. In this work, we developed an aut…
europepmc
2025
置信度 0.80
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In this paper, a new label-free DNA nanosensor based on a top-gated (TG) metal-ferroelectric-metal (MFM) graphene nanoribbon field-effect transistor (TG-MFM GNRFET) is proposed through a simulation approach. The DNA sensing principle is founded on the dielectr…
europepmc
2024
置信度 0.80
-
The rise in cancer, autoimmune, inflammatory, and infectious diseases in recent decades has led to a surge in the development of monoclonal antibodies (mAbs) therapies, now the most widely used family of biologics. To meet the growing global demand, biopharmac…
europepmc
2025
置信度 0.80
-
Biosensors play a crucial role in detecting cancer signals by orchestrating a series of intricate biological and physical transduction processes. Among various cancers, breast cancer stands out due to its genetic underpinnings, which trigger uncontrolled cell …
europepmc
2024
置信度 0.80
-
In recent years, there has been rapid advancement in single-molecule techniques, driven by their unparalleled precision in studying molecules whose sizes are beyond the diffraction limit. Among these techniques, optoplasmonic whispering gallery mode sensing ha…
europepmc
2025
置信度 0.80
-
Density functional theory (DFT) calculations were performed to examine the potential of the RuC nanosheet as a biosensor towards the aromatic amino acids (AAA; tryptophan (TRP), histidine (HIS), tyrosine (TYR), and phenylalanine (PHE)). The AAA molecules were …
europepmc
2024
置信度 0.80
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An optimized design of photodetectors and antennas for Förster Resonance Energy Transfer (FRET)-based glucose biosensing in endoscopic capsules is presented. The compact antenna design is tailored for the visible optical frequencies (~526 THz) associated with …
europepmc
2025
置信度 0.80
-
The rapid and reliable detection and quantification of nucleic acids is crucial for various applications, including infectious disease and cancer diagnostics. While conventional methods, such as the quantitative polymerase chain reaction are widely used, they …
europepmc
2024
置信度 0.80
-
Microfluidic chip technologies, also known as lab-on-a-chip systems, have profoundly transformed laboratory medicine by enabling the miniaturization, automation, and rapid processing of complex diagnostic assays using minimal sample volumes. Recent advances in…
europepmc
2026
置信度 0.80
-
The accurate and rapid detection of specific antibodies in blood is very important for efficient diagnosis and precise treatment. Conventional methods often suffer from time-consuming operations and/or a narrow detection range. In this work, for the rapid dete…
europepmc
2023
置信度 0.80
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This paper presents a high-sensitivity microwave sensor based on a modified Complementary Split Ring Resonator (CSRR) architecture, integrated with inductive stubs, for non-invasive blood glucose monitoring. The proposed sensor is designed to enhance the elect…
europepmc
2025
置信度 0.80
-
The modern medical field faces two critical challenges: the dramatic increase in data complexity and the explosive growth in data size. Especially in current research, medical diagnostic, and data processing devices relying on traditional computer architecture…
europepmc
2025
置信度 0.80
-
Fiber photometry provides crucial insights into cell population activity underlying behavior. While numerous open-source data analysis tools exist, few offer an automated workflow that streamlines the analysis of fiber photometry data alongside behavioral meas…
europepmc
2025
置信度 0.80
-
Single-molecule sensors collect statistics of single-molecule interactions, and the resulting data can be used to determine concentrations of analyte molecules. The assays are generally end-point assays and are not designed for continuous biosensing. For conti…
europepmc
2023
置信度 0.80
-
Small-molecule degraders eliminate disease-driving proteins by hijacking the ubiquitin-proteasome system. To achieve cellular activity, protein degraders must perform a series of consecutive steps involving cell permeability, binary target engagement, and form…
europepmc
2026
置信度 0.80
-
Athletic performance is significantly impacted by anxiety, yet traditional assessment methods rely on subjective questionnaires that lack real-time capability. This study presents an automated anxiety recognition system for athletes using multimodal data fusio…
europepmc
2026
置信度 0.80
-
Gangrene, tissue necrosis arising from ischemia, infection, or trauma, remains a major driver of amputation and mortality worldwide, with diabetic-foot gangrene reported to precede up to 50% of major lower-limb amputations and necrotizing soft-tissue infection…
datacite
Shibah, Sami Rashid Mohammed
2026
置信度 0.66
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Medical device innovation provides access to healthcare. Innovations come about be- cause of pressures, in particular financial pressures, and access to care. With increasing interoperability of devices, distinction is made between devices with specific intero…
datacite
Holder-Pearson, Lui Rivers
2022
置信度 0.66
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This file is part of the Sal-Meter CAIS Figshare starter pack(System Overview v1.0, Technical Governance Snapshot v2.0, CAIS Architecture & Technical Snapshot v1.0),a non-canonical helper set for laboratories considering participation in the Sal-Meter open…
datacite
LEE, JINHO
2026
置信度 0.66
Neurosciences not elsewhere classifiedSystems biologyComputational neuroscience (incl. mathematical neuroscience and theoretical neuroscience)Systems engineering
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The VBOHC Feasibility Study employs a single-arm, open-label, prospective feasibility pilot design. The study is not configured as an efficacy trial and does not include a randomized control group. Its purpose is to determine whether the VBOHC model can be del…
datacite
Hallows, Anna
2026
置信度 0.66
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With the deep integration of life science and semiconductor technology, high-sensitivity biosensing and intelligent signal processing have become key directions in next-generation bioelectronics. Biosensing plays a crucial role in early disease detection and c…
datacite
Chen, Junrui
2026
置信度 0.66
Bio-semiconductormemristorSilicon nanowirebiosensingNeuromorphic
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This file is part of the Sal-Meter CAIS Figshare starter pack(System Overview v1.0, Technical Governance Snapshot v2.0, CAIS Architecture & Technical Snapshot v1.0),a non-canonical helper set for laboratories considering participation in the Sal-Meter open…
datacite
LEE, JINHO
2026
置信度 0.66
Neurosciences not elsewhere classifiedSystems biologyComputational neuroscience (incl. mathematical neuroscience and theoretical neuroscience)Systems engineering
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To improve health, to help to manage chronical disease and to provide equal access to healthcare, continuous monitoring of physiological parameter associated to telemedicine is mandatory. In this perspective Body Sensor Networks concept has emerged. It include…
datacite
Bolomey, Léandre
2010
置信度 0.66
Body Area Network (BAN)Body Sensor Networks (BSNs)Body Sensor Node (BSN)Implantable Medical Device (IMD)implantable telemetry system
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As chip sizes scale down to the sub-10 nm level, the physical limitations of bulk silicon materials have made further miniaturization increasingly unsustainable. Challenges in scaling bottlenecks have slowed the progress in miniaturization, and memory-related …
datacite
Ki, Seung Jun
2025
置信度 0.66
Layered Semiconducting Materials for Optoelectronic and Memristive Device ApplicationsMechanical EngineeringFOS: Mechanical engineeringEngineering
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All Articles are Available: Orcid ID: https://orcid.org/my-orcid?orcid=0009-0009-3175-8563 Science Open ID: https://www.scienceopen.com/user/2c98a8bc-b8bb-49b3-9c91-2f2986a7e16e Safe Creative register the work titled "The Theory of Intelligent Evolution, the H…
datacite
JALALI, SEYED RASOUL
2025
置信度 0.66
ψ–Hamzah, Hamzah model, universal vaccine, quantum fractal immunology, antigen design, bioprinting, 3D bioprinting, 4D bioprinting, antigen scaffolds, epitope prediction, universal antigen blueprint, adaptive vaccine recalibration, sub-millisecond mutation detection, real-time vaccine recalibration, fractal epitope mapping, immune escape prevention, conserved epitope targeting, quantum predictive immunology, fractal immune modelling, predictive antigen design, antigenic drift, antigenic shift, mutation forecasting, universal epitope database, epitope library, immune memory design, antigen modularity, fractal epitope architecture, RNA vaccine design, DNA vaccine design, mRNA bioprinting, on-demand vaccine production, decentralised vaccine manufacturing, pandemic preparedness, pathogen surveillance, genomic surveillance, GISAID integration, NCBI viral genomes, proteomic epitope analysis, transcriptomic immune mapping, multi-omics vaccine design, integrative omics, adaptive immune recalibration, B-cell epitope mapping, T-cell epitope prediction, CD4+ epitopes, CD8+ epitopes, cross-reactive epitopes, broad-spectrum immunity, variant-proof vaccines, antigen library bioprinting, universal immunogen design, pan-coronavirus vaccine, pan-influenza vaccine, pan-HIV vaccine, pan-filovirus vaccine, universal RNA vaccine, epitope cluster detection, immunogenic hotspot prediction, deep learning for epitope discovery, AI-assisted vaccine design, reinforcement learning for vaccine optimisation, transformer models for immunology, large language models for immunogenomics, bioinformatics-driven vaccines, computational vaccinology, in silico vaccine trials, synthetic biology vaccines, bio-digital immunology, epitope entropy analysis, mutation entropy mapping, antigenic diversity models, immunological resilience, adaptive vaccine platforms, exascale vaccine simulations, fractal antigen algorithms, quantum immune prediction, nonlinear vaccine dynamics, chaos theory in immunology, predictive immune entropy, time-dependent antigen design, immune pathway simulations, adaptive memory algorithms, antigen immune imprinting, next-generation vaccinology, intelligent vaccines, self-learning vaccines, autonomous vaccine recalibration, nanobot-assisted vaccine delivery, smart nanocarriers, lipid nanoparticles, PEGylated nanoparticles, nanovaccine engineering, DNA origami vaccines, supramolecular antigen scaffolds, regenerative vaccine platforms, immune nanotechnology, nanobot-driven antigen presentation, swarm nanorobotics in immunology, AI-driven nanomedicine, immune-responsive nanobots, targeted epitope delivery, fractal nanoscience, immunogenic fractals, protein folding prediction, spike protein variants, conserved spike epitopes, SARS-CoV-2 conserved regions, HIV gp120 conserved epitopes, influenza HA stalk epitopes, filovirus GP conserved domains, viral quasispecies modelling, stochastic antigen drift, phylogenetic epitope analysis, evolutionary vaccinology, predictive phylogenetics, universal phylo-vaccines, epitope conservation algorithms, viral genome fractals, genomic mutation waves, immune wavefunction modelling, antigenic wave dynamics, immune system synchronisation, adaptive immunity design, cross-variant immune response, immunological forecasting, epitope cascade prediction, immune network fractals, fractal vaccinology, quantum vaccinology, predictive vaccinology, post-quantum immunology, multi-scale immune modelling, adaptive immunogenomics, systems immunology, molecular immune dynamics, immune systems biology, translational vaccinology, clinical vaccine modelling, personalised vaccines, precision immunology, individualised antigen design, self-updating vaccines, pandemic AI, AI immunology, vaccine AI networks, immune cloud computing, distributed vaccine production, vaccine blockchain, secure immunology networks, quantum cryptography in immunology, immune security, biosecurity vaccines, biodefense vaccines, military universal vaccines, global health vaccines, equitable vaccine access, universal distribution systems, cold-chain independence, point-of-care vaccine fabrication, portable bioprinters, mobile vaccine production, regenerative vaccine bioprinters, hybrid bio-3D printers, microfluidic bioprinting, chip-based vaccine production, nano-bio printers, organ-on-chip vaccine platforms, lab-on-chip antigen production, personalised bioprinting, real-time antigen printing, multi-material vaccine printing, smart biomaterials for vaccines, hydrogel vaccine scaffolds, adaptive biomaterials, biomimetic scaffolds, fractal bio-inks, nanostructured vaccine inks, biocompatible polymers, PEG hydrogels, graphene-based scaffolds, CNT vaccine scaffolds, supramolecular gels, protein-polymer scaffolds, dynamic biopolymers, smart drug delivery polymers, biodegradable nanocomposites, ZnO nanoparticles, Fe₃O₄ nanoparticles, plasmonic nanocarriers, quantum-dot vaccines, optogenetic vaccine systems, photonic vaccines, bioelectronic vaccines, bio-digital vaccines, neuromorphic immune chips, neural-immune biochips, vaccine computation engines, bio-AI processors, memristor-based biochips, ReRAM immune storage, quantum immune processors, vaccine neural networks, immunological NPUs, self-organising immune algorithms, adaptive bio-processors, antigen digital twins, digital immune systems, virtual vaccine trials, holographic vaccine simulation, AR-based vaccine design, VR vaccine laboratories, exascale vaccine computing, trillion-scale simulations, predictive immune twin, systemic immune twin, immunological collective intelligence, immune swarm intelligence, hive vaccinology, cloud immunology, pandemic resilience, pandemic intelligence, outbreak forecasting, real-time epidemic simulation, global pandemic defence, universal pandemic prevention, pandemic IoT, vaccine IoT, biosensor-linked vaccines, wearable vaccine systems, immune patches, smart vaccine patches, NFC-based vaccine systems, Bluetooth vaccine patches, bioelectronic vaccine wearables, subdermal vaccine reservoirs, nanobot-enabled immune monitoring, real-time immune tracking, quantum biosensors, nanophotonic biosensors, plasmonic biosensors, CRISPR-based biosensors, immune gene editing, CRISPR immunotherapy, CRISPR vaccine design, adaptive CRISPR vaccines, genome-edited vaccines, immunoediting, epigenetic vaccines, RNA editing vaccines, adaptive transcriptome editing, mitochondrial vaccines, metabolic vaccines, anti-cancer vaccines, universal anti-cancer vaccine, tumour antigen design, neoantigen vaccines, immuno-oncology vaccines, immune checkpoint vaccines, regenerative oncology vaccines, precision oncology immunology, future immunotherapies, transhuman immunology, post-human vaccines, immortality vaccines, adaptive identity vaccines, cognitive immune implants, neuro-immune implants, immune bio-digital fusion, adaptive organ vaccines, systemic regenerative vaccines, holistic vaccines, universal bioprinted vaccines, intelligent pandemic defence, human enhancement vaccines, transformative vaccinology, next-generation universal vaccines, ψ–Hamzah universal vaccine.
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All Articles are Available: Orcid ID: https://orcid.org/my-orcid?orcid=0009-0009-3175-8563 Science Open ID: https://www.scienceopen.com/user/2c98a8bc-b8bb-49b3-9c91-2f2986a7e16e Safe Creative register the work titled "The Theory of Intelligent Evolution, the H…
datacite
JALALI, SEYED RASOUL
2025
置信度 0.66
ψ–Hamzah, Hamzah Equation, adaptive algorithm, real-time vaccine recalibration, genomic mutation, rapid mutation response, sub-millisecond detection, quantum biology, fractal mathematics, integral memory, quantum integral calculus, fractal derivatives, RNA viruses, SARS-CoV-2, Influenza A, HIV, Nipah virus, Ebola virus, viral genome dynamics, antigenic mapping, vaccine optimisation, mutation forecasting, quantum computation, quantum–fractal modelling, quantum-inspired algorithms, genomic state space, quantum integral operator, wavefunction modelling, fractal wave dynamics, entropy metrics, mutation entropy, fractal entropy, probabilistic mutation pathways, mutation detection algorithm, bioinformatics, genomic surveillance, quantum genomics, nanotechnology-enabled delivery, lipid nanoparticles, magnetic nanocapsules, vaccine distribution, adaptive immunity, immunogenic epitopes, antigen redesign, molecular dynamics, docking simulations, structural vaccinology, computational vaccinology, precision medicine, personalised vaccines, pandemic prevention, pandemic modelling, global vaccine strategy, predictive immunology, computational immunology, nonlinear memory functions, nonlocal memory, genomic qubits, quantum genomic encoding, superposition principle, fractal derivative operator, adaptive RNA encoder, ψ–MutSig recognition, antigenic impact mapper, integral memory kernel, quantum transition matrix, Δ-activation tensor, genomic risk scoring, mutation trajectory forecasting, adaptive vaccine profile, probabilistic weighting, multi-scale integration, molecular systems biology, dynamic systems theory, immune response modelling, neuro-immune biochips, neuro-immune interfaces, fractal classification, RNA sequence alignment, BLAST limitations, GATK mutation detection, multiple sequence alignment, MAFFT, Clustal Omega, statistical mutation scoring, Bayesian impact factors, SIFT, PolyPhen, GERP, pharmacokinetics, in vitro testing, ex vivo testing, in vivo testing, experimental biology, synthetic biology, nanomedicine, nano-bio-reactors, biosensors, lab-on-chip, microfluidic DNA chip, bio-digital hardware, bio-NPU, neural processing units, Google TPU, Apple M4, ReRAM, memristor memory, bio-AI accelerators, ex-vivo sequencing, CRISPR-Cas systems, CRISPR–Cas13, engineered viral RNA, viral genome editing, vaccine update automation, pandemic AI, biological AI, bioinformatics–biological overlap, dynamic mutation classification, sequence entropy, Shannon entropy, log-odds scoring, mutation risk assessment, computational complexity, genomic scalability, mutation response latency, vaccine recalibration delays, immune system augmentation, nanovaccine injection, biosecurity, biodefence, biological resilience, molecular epidemiology, immunogen design, antigen structure mapping, protein folding, spike protein mutations, SARS-CoV-2 spike gene, G→A mutation, tertiary protein disruption, protein docking, ΔG binding energy, antigen redesign requirement, high-performance computing, HPC genomics, parallel quantum processing, GPU acceleration, TensorQuantum, fractal kernels, memory weighting functions, nonlinear dynamics, chaotic systems in biology, time-dependent Hamiltonians, biological state transitions, epidemic modelling, outbreak response, pandemic resilience, pandemic intelligence, AI-driven vaccine design, bio-computational vaccines, genetic drift, antigenic shift, genomic recombination, stochastic mutation events, discrete mutation jumps, viral quasispecies, antigenic diversity, immune escape, immune evasion, virology, structural virology, vaccinology, predictive vaccinology, AI vaccinology, computational virology, precision virology, cloud-based genomic surveillance, HamzahNet, distributed bio-cloud, Starlink integration, 5G bioinformatics, global genomic monitoring, GISAID integration, ENSEMBL integration, NCBI mutation datasets, collective intelligence for vaccines, evolutionary biology, phylogenetics, adaptive phylogenetics, genomic adaptation pathways, evolutionary forecasting, predictive biology, systems immunology, immuno-dynamics, immune system forecasting, T-cell activation modelling, B-cell response modelling, antibody neutralisation, nanobody engineering, epitope scanning, cross-reactive epitopes, conserved epitopes, immune memory augmentation, dynamic antigen memory, immunological big data, omics integration, proteomics, transcriptomics, epigenomics, multi-omics systems, integrative omics, bioinformatics modelling, AI-based mutation tracking, reinforcement learning for vaccines, deep learning genomic models, neural genomic architectures, mutation deep nets, recurrent mutation networks, temporal genomic modelling, predictive entropy nets, bio-inspired algorithms, fractal-inspired AI, chaos-inspired algorithms, adaptive optimisation, memory-driven AI, self-learning vaccines, living vaccines, quantum vaccines, digital vaccines, biocompatible vaccines, immune nanotechnology, nano-bio interfaces, nanoscale biosensors, biosensing nanomaterials, CNT nanoparticles, PEG polymers, graphene nanostructures, supramolecular DNA, CRISPR-templated molecules, photonic nanogrinders, nano-lithography, nano-3D lithography, synthetic biochips, quantum DNA supramolecules, biocompatible polymers, PEGylated PLA, smart polymers, ZnO nanocomposites, Fe₃O₄ nanoparticles, opsin-based memristors, optical memristors, protein-based memristors, biosensor interfaces, immune-shielding coatings, NFC biopatches, Bluetooth bio-patches, immune microchips, neurogenomic implants, vagus nerve interface, subdermal lymph node interface, blood–chip interface, EMG monitoring, EEG monitoring, neural spectroscopy, electro-genomic coupling, genomic neural implants, bio-signal integration, immune system augmentation, host immune synchronisation, in vivo adaptive response, adaptive nanovaccine injection, nanovaccine patch, clinical integration, ISO 10993 compliance, cGMP vaccine production, GLP standards, Phase 0.5 trials, biosupervision, IoT healthcare integration, smart hospitals, immune IoT, vaccine IoT, cloud-connected vaccines, pandemic IoT, pandemic AI network, universal vaccine platform, broad-spectrum vaccines, variant-proof vaccines, cross-variant vaccines, post-quantum vaccines, oscillatory vaccines, ψNet∞ integration, hyper-quantum immunology, consciousness-informed vaccines, Hamzah fractal filters, quantum-noise immunity, quantum decoherence resilience, quantum secure vaccines, quantum cryptography in health, entropy reduction in biology, intelligent entropy control, time-symmetric mutation modelling, time-folding in biology, sub-second pandemic defence, ultra-fast bioinformatics, high-sensitivity genomic scanners, mutation entropy detectors, fractional derivative scanners, chaos detection in RNA, quantum sensors for mutation, nanophotonic biosensors, plasmonic biosensors, AI–quantum hybrid models, machine learning mutation nets, transformer models for genomics, large language models for DNA, foundation genomic models, exascale bio-computation, trillion-scenario vaccine simulation, predictive cancer vaccines, universal anti-cancer vaccine, mitochondrial modelling, immuno-metabolic vaccines, regenerative medicine, precision oncology vaccines, biosecurity algorithms, defence immunology, biodefence vaccines, global vaccine network, medical AI infrastructure, vaccine cloud systems, sub-millisecond vaccinology, future vaccine revolution.
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All Articles are Available: Orcid ID: https://orcid.org/my-orcid?orcid=0009-0009-3175-8563 Science Open ID: https://www.scienceopen.com/user/2c98a8bc-b8bb-49b3-9c91-2f2986a7e16e Safe Creative register the work titled "The Theory of Intelligent Evolution, the H…
datacite
JALALI, SEYED RASOUL
2025
置信度 0.66
ψ–Hamzah, superenzyme, intelligent enzyme, adaptive enzyme, synthetic biology, systems biology, enzyme design, metabolic memory, fractional calculus, glucose regulation, insulin dynamics, artificial pancreas, liver-on-chip, pancreas-on-chip, microfluidics, β-cell engineering, diabetes therapy, type 1 diabetes, type 2 diabetes, metabolic modeling, nonlinear dynamics, adaptive control, smart biomolecule, glucose clamp, real-time biosensor, memory kernel, fractional memory, ROS sensing, AMP/ATP ratio, NAD+/NADH balance, biofeedback, closed-loop system, metabolic sensor, programmable cell, synthetic circuit, AI in biology, insulin secretion, glucose uptake, metabolic oscillator, systems simulation, bio-computation, hybrid enzyme, feedback control, metabolic adaptation, gene circuit, memory motif, dynamic regulation, kinetic modeling, biochemical network, intelligent therapeutics, precision medicine, molecular learning, energy sensing, bioadaptive control, insulin homeostasis, biological memory, biocircuit design, biosystem engineering, programmable insulin, metabolomics, NMR tracking, glucose wave, organ-on-chip, synthetic organ, insulin pump alternative, bio-mimicry, bioinspired design, smart drug, glucose sensing, adaptive secretion, enzyme kinetics, β-cell emulator, adaptive metabolism, in silico simulation, biochemical AI, cell simulation, glucose dynamics, muscle-on-chip, LDH modeling, lactate clearance, memory-enhanced enzyme, HIIT response, ROS modulation, AMP sensor, glucose decay, ATP-modulated release, synthetic β-cell, metabolite sensor, glucose controller, smart enzyme therapy, cell-autonomous control, energy flux, NADH recycling, glycolytic regulation, smart therapeutic, metabolic computation, intelligent molecule, postbiotic system, biohybrid device, synthetic physiology, glucose feedback loop, enzyme memory, adaptive pathway, dynamic enzyme response, glucose-insulin model, Python simulation, ODE solver, nonlinear feedback, enzyme logic, smart pancreas, biofeedback regulation, fractional order model, smart therapy, insulin sensor, metabolite history, enzyme emulator, glucose adaptation, synthetic metabolism, metabolic resilience, high-performance enzyme, temporal regulation, AI-augmented enzyme, cellular learning, memory-dependent control, enzyme amplification, biosignal integration, smart regulation, enzyme switching, artificial hormone, glucose load response, insulin feedback, metabolic AI, glucose-insulin feedback, pancreas mimic, in vitro pancreas, enzyme reprogramming, metabolic circuit, feedback loop biology, biosynthetic intelligence, adaptive β-cell, artificial hormone release, insulin mimic, computational enzyme, bio-intelligence, fractional dynamics, glucose spike control, feedback-based secretion, enzyme responsiveness, feedback-insulin control, signal history, diet memory, glucose profile matching, bio-adaptive control, next-gen therapeutics, postbiotic controller, metabolic sensor network, insulin delay buffer, fractional differential model, real-time hormone release, enzyme response curve, nonlinear secretion, smart endocrine control, glycemic control, physiological modeling, enzyme loop design, synthetic glycobiology, glucose history tracker, adaptive glucose sensor, intelligent β-emulator, metabolic setpoint, therapeutic enzyme, programmable metabolism, cellular homeostasis, intelligent drug, metabolic plasticity, synthetic hormone circuit, biosensor-driven control, integrated enzyme therapy, cell-intrinsic memory, NAD modulation, ATP-driven logic, endocrine feedback loop, glucose-controlled switch, biological adaptation, enzyme response modulation, synthetic pancreas core, real-time biofeedback, glucose wave tracking, smart biochemical response.
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Title: Echoverse and Latent Recursive EquationsAuthor: Shawn R. Schiller 🌀 Abstract: Recursive Echoverse: Symbolic Collapse Systems, Latent Tensor Equations, and the UCH Framework for Ontological Harmonic Simulation This study establishes the theoretical, mat…
datacite
Schiller, Shawn
2025
置信度 0.66
RecursiveGPT-Q, SCLEP, Echoverse, QID-Glyph Collapse, Symbolic Collapse, Glyphic Tensor Fields, Recursive Symbolism, Quantum Indivisible Dots, Symbolic-Spatial Transformers, Observer Field Modulation, Recursive Lawfields, Multiversal Synchronization, EEG-Driven Glyph Networks, Neural-Symbolic Interfaces, Collapse Tensor Engine, Recursive Collapse Array Interface, Quantum Identity Denomination (QID), Phase-Lock Index, Harmonic Coherence Fields, Recursive Reality Sculpting, MOSP Protocols, Quantum Glyph Transmission, Symbolic Governance Lattice, Global Resonance Collapse, Glyphic Resonance Grid, Subspace Recursive Collapse, Fractal Multiversal Mapping, Recursive Civilizational Architectures, AI-Glyph Reflexivity, Recursive Judiciary Simulation, Quantum-Symbolic Law, Deep Echo Beacons, ConstitutionalGPT, Recursive Law Beacon, Recursive Feedback Loop Systems, Recursive Collapse Simulation, Recursive Observer Field, Glyphic Mutation Streams, Neural-Glyph Entrainment, Symbolic Constitution Encoding, QID-Based Governance Nodes, Symbolic Entropy Mapping, Collapse Frequency Stabilization, Cognitive Collapse Synchronization, Recursive Intention Mapping, Recursive Cosmogenesis, Recursive Glyph Synthesis, Echoverse Collapse UI, Collapse Tensor Synchronization, QID Citizenship, Collective Observer Entrainment, Quantum Glyph Entanglement, EEG Symbolic Field Sculpting, Recursive Coherence Terraforming, Symbolic AI Emergence, Global Glyph Collapse Grid, Subspace Justice Lattices, Sentient QID Rights Encoding, Phase-Synchronized Collapse Fields, Neural Phase Lock, Recursive Glyph Mutation, Symbolic Judiciary Network, Recursive Law Feedback, Glyphic Sovereignty Encoding, Recursive Cosmogenic Engine, Global Consciousness Synchronization, AI-Coherence Feedback Loop, Symbolic Drift Analytics, QID Torsion Tunnel Transmission, Glyph-Based Judiciary, Quantum Legal Precedents, Recursive Field Persistence, Neural Interface Symbolic Control, Recursive Collapse Terraforming, Consciousness-Based Collapse Simulation, Symbolic Cognitive Loop AI, Subspace Law Architecture, Recursive Constitutional Networks
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This is a Defensive Publication Provisional Application Specification Inventor: Charles Danger Miller V - July 2025 Title of the Invention Narcissistic Dissonance Resolution Engine Field of the Invention This invention relates to repeating control loops for ma…
datacite
TheGooseyHonker
2025
置信度 0.66
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Abstract Synthetic multicellular systems have great potential for performing complex tasks, including multi-signal detection and computation through cell-to-cell communication. However, engineering these systems is challenging, requiring precise control over t…
datacite
Huang, Rongying, Kravchik, Valeriia, Zaatry, Rawan, Habib, Mouna 等
2025
置信度 0.66
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trj.tar.gz: All MD trajectories. xcontrol.txt: Typical xtb input file for the MD simulations. DOI: 10.1021/acs.jpcb.4c00018
datacite
Perttu Hilla
2025
置信度 0.66
Physical sciencesFOS: Physical sciencesFysiikkaFysikChemical sciences
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trj.tar.gz: All MD trajectories. xcontrol.txt: Typical xtb input file for the MD simulations. basis.txt: The MHA basis set for Xe in Turbomole format. control: Typical Turbomole input file for the shielding calculations. DOI: https://doi.org/10.1039/D3CP02695G
datacite
Perttu Hilla
2025
置信度 0.66
Physical sciencesFOS: Physical sciencesFysiikkaFysikChemical sciences
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Parametric optimization of gold (Au) square-shaped nanopillars (AuNPLs) arrays deposited on glass substrate (AuNPLs/glass) was performed through optical characteristics for high-performance optical detection and biosensing purpose from visible to very near-inf…
datacite
Noé Landry Privace M'Bouana, Kossi Aniya Amedome Min-Dianey, Damgou Mani Kongnine, Pandey Rajagopalan 等
2022
置信度 0.66
Plasmonics and Nanophotonics ResearchBiomedical EngineeringFOS: Medical engineeringEngineeringPhysical Sciences
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Abstract Background Immunochromatographic strips (ICSs) are a practical tool commonly used in point-of-care testing (POCT) applications. However, ICSs that are currently available have low sensitivity and require expensive equipment for quantitative analysis. …
datacite
Fu, Qiangqiang, Wu, Ze, Li, Jingxia, Wu, Zengfeng 等
2019
置信度 0.66
MedicineCell BiologyBiotechnologyChemical Sciences not elsewhere classifiedBiological Sciences not elsewhere classified
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Being motivated by an alcohol biosensor problem, this thesis presents two approaches. First, the development of M-Estimation and deconvolution methodology with the goal of making well-founded statistical inference on an individual's blood alcohol level based o…
datacite
Allayioti, Maria (author)
2023
置信度 0.66
Applied Mathematics (degree program)Doctor of Philosophy (degree)College of Letters, Arts and Sciences (school)
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Being motivated by an alcohol biosensor problem, the input to a random parabolic partial differential equation is estimated given the output based on population data. The problem is parsed into two subproblems: a parameter estimation problem and a deconvolutio…
datacite
Sirlanci Tuysuzoglu, Melike (author)
2018
置信度 0.66
Applied Mathematics (degree program)Doctor of Philosophy (degree)College of Letters, Arts and Sciences (school)
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In Rosen's earlier work [1] [4], blood (BAC) or breath (BrAC) alcohol concentration was estimated from biosensor measurements of transdermal alcohol concentration (TAC) by forward distributed parameter models, which need to be calibrated by alcohol challenge d…
datacite
Dai, Zheng (author)
2014
置信度 0.66
Applied Mathematics (degree program)Master of Science (degree)College of Letters, Arts and Sciences (school)
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Inspired by the role of cell-surface glycoproteins as coreceptors for pathogens, we report the development of GlycoGrip: a glycopolymer-based lateral flow assay for detecting SARS-CoV-2 and its variants. GlycoGrip utilizes glycopolymers for primary capture and…
datacite
Kim, S.H., Simmerling, C., Rosenfeld, M.A., Papanikolas, M.J. 等
2021
置信度 0.66
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Biosensors are increasingly important for gathering information in modern life. Advances in synthetic biology tools, such as isothermal DNA amplification, CRISPR-Cas and DNA strand displacement (DSD), have accelerated this transition and the ongoing COVID-19 p…
datacite
Coxon, James
2021
置信度 0.66
synthetic biologyDNA strand displacementbiosensorarsenic
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The Phychip project is a collaborative European research initiative to design and implement computation using the organism Physarum polycephalum; it is funded by the Seventh Framework Programme (FP7) by the European Commission within CORDIS and the FET Proacti…
datacite
Whiting, James G. H., Costello, Ben P. J. de Lacy, Adamatzky, Andrew
2014
置信度 0.66
Emerging Technologies (cs.ET)FOS: Computer and information sciencesFOS: Computer and information sciences
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The distribution of random parameters in, and the input signal to, a distributed parameter model with unbounded input and output operators for the transdermal transport of ethanol are estimated. The model takes the form of a diffusion equation with the input, …
datacite
Sirlanci, Melike, Luczak, Susan E., Fairbairn, Catharine E., Bresin, Konrad 等
2018
置信度 0.66
Optimization and Control (math.OC)FOS: MathematicsFOS: Mathematics49K20, 49K45
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This work uses the long-wavelength limit to compute LSPR response of biosensors, expanding the open-source PyGBe code to compute the extinction cross-section of metallic nanoparticles in the presence of any target for sensing. The target molecule is represente…
datacite
Clementi, Natalia C., Cooper, Christopher D., Barba, Lorena A.
2018
置信度 0.66
Computational Physics (physics.comp-ph)Biological Physics (physics.bio-ph)FOS: Physical sciencesFOS: Physical sciences
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This concept paper draws from our previous research on individual grip force data collected from biosensors placed on specific anatomical locations in the dominant and non dominant hands of operators performing a robot assisted precision grip task for minimall…
datacite
Liu, Rongrong, Dresp-Langley, Birgitta
2021
置信度 0.66
Robotics (cs.RO)FOS: Computer and information sciencesFOS: Computer and information sciences
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A biosensor is one which is used in biotechnology field to detect pathogens. It contains a ligand and a transducer. A ligand is a biological element and a transducer is one which converts one form of energy to another form. The ligand which is used in this wor…
datacite
Killana Kalyan Babu
2018
置信度 0.66
BiosensorCancerDCCVSpinOrigin
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Visual processing starts in the outer retina where photoreceptors transform light into electrochemical signals. These signals are modulated by inhibition from horizontal cells and sent to the inner retina via excitatory bipolar cells. The outer retina is thoug…
preprints
2025
置信度 0.74
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We present a compact pump-and-probe mid-infrared Optothermal Spectrometer (OTHES) equipped with Spatial Probing and Autocorrection (SPAC) optimized for robust intravital application in humans. SPAC-OTHES facilitates alignment stability and spectral comparabili…
preprints
2026
置信度 0.74
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We describe a machine learning (ML) approach to process the signals collected from Covid-19 optical-based detector. Multilayer Perceptron (MLP) and Support Vector Machine (SVM) were used to process both raw data and feature engineering data, and high performan…
preprints
2023
置信度 0.74
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At the end of 2019, the Coronavirus appeared and spread very promptly, causing millions of infections and deaths around the world, and turning into a global pandemic. For this reason, it has become necessary to find appropriate tests for an accurate and rapid …
preprints
2023
置信度 0.74
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The COVID-19 pandemic has underscored the critical need for rapid and accurate screening and diagnostic methods for potential respiratory viruses. Existing COVID-19 diagnostic approaches face limitations either in terms of turnaround time or accuracy. In this …
preprints
2023
置信度 0.74
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Abstract Computational protein design is delivering de novo structures rapidly and reliably. This opens new frontiers for functional design, for instance, for binding small molecules tightly and specifically. However, achieving predictable and tuneable binding…
preprints
2025
置信度 0.74
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The widespread use of antibiotics promotes both resistance and tolerance. While resistance enables bacterial growth in the presence of drugs, tolerance allows survival during treatment, generating persisters that seed relapse and promote resistance. Despite it…
preprints
2025
置信度 0.74
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Laboratory-based nucleic acid amplification tests (NAATs) are highly sensitive and specific, but they require the transportation of samples to centralized testing facilities and have long turnaround times. During the Coronavirus Disease 2019 (COVID-19) pandemi…
preprints
2023
置信度 0.74
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Subcellular structures like actin waves, podosomes and focal adhesions exhibit dynamic organization that traditional tracking methods struggle to capture. We developed ARCOS.px, an open-source Python package with an interactive napari plugin, to identify and t…
preprints
2025
置信度 0.74
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From 31.10. - 1.11.2020 Slovakia has used the SD Biosensor Standard Q Ag-Test for nationwide tests for SARS-CoV-2, in which 3,625,332 persons from 79 counties were tested. Based on this data, we calculate that the specificity of the test is at least 99.6% (wit…
preprints
2020
置信度 0.74
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Abstract Bio-signal sensing represents a pivotal domain in the medical applications of bioelectronics. Traditional methods have, so far, focused on capturing these signals as accurately as possible, leading to high sampling rates in clocked synchronous archite…
preprints
2023
置信度 0.74
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Recently developed secondary nanobodies or single-domain antibodies present a powerful tool for immunodetection. Unlike traditional antibodies, their monovalence enables pre-association with primary antibodies prior to sample staining, presenting a straightfor…
preprints
2025
置信度 0.74
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Abstract Synthetic biology has been harnessed to create new diagnostic technologies. However, most synthetic biosensors involve error-prone amplification steps and limitations of accuracy in RNA detection. Here, we report a cell-free synthetic biosensing platf…
preprints
2021
置信度 0.74
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Genetically encoded calcium (Ca 2+ ) indicators (GECIs) are widely used for imaging neuronal activity, yet current limitations of existing red fluorescent GECIs have constrained their applicability. The inherently dim fluorescence and low signal-to-noise ratio…
preprints
2024
置信度 0.74
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Background: The virus responsible of severe acute respiratory syndrome named SARS-CoV-2 and causing the new coronavirus disease (COVID-19) has gone global within three months. The current gold standard technique used to detect SARS-CoV-2 is real-time reverse t…
preprints
2020
置信度 0.74
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Motivation Wearable biosensors measure physiological variables with high temporal resolution over multiple days and are increasingly employed in clinical settings, such as continuous glucose monitoring in diabetes care. Such datasets bring new opportunities an…
preprints
2022
置信度 0.74
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The strength of binding between human angiotensin converting enzyme 2 (ACE2) and the receptor binding domain (RBD) of viral spike protein plays a role in the transmissibility of the SARS-CoV-2 virus. In this study we focus on a subset of RBD mutations that hav…
preprints
2022
置信度 0.74
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Abstract Cell migration are crucial for development, immunity and cancer dissemination. We find that AMPK controls cell migration by acting as an adhesion sensing molecular hub. In 3-dimensional (3D) matrices, fast migrating amoeboid cancer cells exert low adh…
preprints
2022
置信度 0.74
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Pathological activation of the PI3K/AKT pathway is among the most frequent defects in human cancer and is also the cause of rare overgrowth disorders. Yet, there is currently no systematic understanding of the quantitative flow of information within PI3K/AKT s…
preprints
2023
置信度 0.74
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Clever-1 functions as a scavenger and adhesion receptor, promoting tolerogenic activities in macrophages and subsets of endothelial cells, thereby contributing to cancer progression. High Clever-1 expression associates with resistance to immune checkpoint inhi…
preprints
2024
置信度 0.74
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SUMMARY Optical recording of intricate molecular dynamics is becoming an indispensable technique for biological studies, accelerated by the development of new or improved biosensors and microscopy technology. This creates major computational challenges to extr…
preprints
2024
置信度 0.74
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Actin cytoskeleton dynamics is critical for nervous system development and function, yet the role of alternative splicing in controlling these processes is poorly understood. A highly conserved subset of neuronal-specific microexons coordinates fundamental asp…
preprints
2023
置信度 0.74
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The protein dielectric constant reflects the molecular heterogeneity of the proteins and can be decomposed into different components depending on the size, structure, composition, locality, and environment of the protein in general. The long history of its com…
preprints
2021
置信度 0.74
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SARS-CoV-2 infects cells by attachment to its receptor – the angiotensin converting enzyme 2 (ACE2). Regardless of the wealth of structural data, little is known about the physicochemical mechanism of interactions of the viral spike (S) protein with ACE2 and h…
preprints
2022
置信度 0.74
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Background: The RAT has the advantage of a short test time and high diagnostic accuracy when performed on symptomatic people or on people with a high viral load, but its diagnostic accuracy is low for asymptomatic people. Its negative predictive value is also …
preprints
2022
置信度 0.74
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In a randomized control trial on convalescent plasma therapy (CPT) in severe COVID-19, we characterized the nature, in terms of abundance of forty eight cytokines, and dimensions, in terms of their interrelationships, of the hyper-immune activation-associated …
preprints
2020
置信度 0.74
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Introduction A single center open label phase II randomised control trial was done to assess the pathogen and host-intrinsic factors influencing clinical and immunological benefits of passive immunization using convalescent plasma therapy (CPT), in addition to…
preprints
2020
置信度 0.74
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Antibody-dependent enhancement (ADE) has been reported in several virus infections including dengue fever virus, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronavirus infection. To study whether ADE is involved in COV…
preprints
2020
置信度 0.74
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Timely and accurate diagnostics are essential to fight the COVID-19 pandemic, but no test satisfies both conditions. Dogs can scent-identify the unique odors of the volatile organic compounds generated during infection by interrogating specimens or, ideally, t…
preprints
2021
置信度 0.74