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Abstract Biological systems navigate and interact with complex, dynamic environments by seamlessly integrating proprioception and exteroception to drive sophisticated sensorimotor loops. Soft robots mimic biological compliance, yet equipping them with simultan…
preprints
2025
置信度 0.74
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Studies of the early visual system often require characterizing the visual preferences of large populations of neurons. This task typically requires multiple stimuli such as sparse noise and drifting gratings, each of which probe only a limited set of visual f…
preprints
2025
置信度 0.74
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Abstract Background . Patient-centred outcome measures (PCOMs), when well implemented, are powerful tools facilitating patient, family and clinical communication to better respond to patient needs throughout the disease trajectory. Their routine use in palliat…
preprints
2025
置信度 0.74
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To behave adaptively in the environment and select appropriate responses to sensory stimuli, animals integrate learnt information about the valences of stimuli with contextual information. While significant progress has been made in understanding how animals l…
preprints
2025
置信度 0.74
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Spinal cord injury (SCI) leads to profound disruptions in sensorimotor processing. Seminal research in non-human primates suggests this sensory deprivation causes functional remapping in the primary somatosensory cortex (S1), where somatotopic representations …
preprints
2025
置信度 0.74
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Normative Modelling (‘brain growth charting’) is now a well-established method for computational psychiatry and involves charting centiles of variation across a population in terms of mappings between biology and behavior, providing statistical inferences at t…
preprints
2026
置信度 0.74
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VasoTracker 2 is an open-source platform for studying blood vessel dynamics, featuring versatile diameter-tracking software and complementary low-cost hardware components. This system surpasses existing tools through accessible, high-resolution analysis across…
preprints
2025
置信度 0.74
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Abstract The loss of hand function is one of the most devastating impairments for individuals with paralysis. While current neurotechnologies can partially restore prehensile control, they fall short of enabling independent finger movements — an essential requ…
preprints
2025
置信度 0.74
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In two-photon imaging of neuronal activity it is increasingly common to acquire 3-dimensional volumes. However, these volumes are typically processed plane by plane, leading to uncorrected axial movement, duplicated cells across planes, reduced signal-to-noise…
preprints
2025
置信度 0.74
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The inherent ability of sensory neurons to entrain to modulations in the temporal structure of an auditory stimulus gives rise to the auditory steady-state response (ASSR). Simultaneous presentation of multiple acoustic stimuli by frequency tagging them to gen…
preprints
2025
置信度 0.74
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Biophysical neuron modeling is an indispensable tool in neuroscience research, with the combination of diverse ion channel kinetics and morphologies being used to explain various single-neuron properties and responses. Despite this, there is no standard way of…
preprints
2025
置信度 0.74
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Abstract Substance use disorder (SUD) stands as a critical public health concern, contributing to substantial morbidity, mortality and societal costs. The effects of SUD on structural brain changes have been well documented. However, the neural mechanisms unde…
preprints
2025
置信度 0.74
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During development, neural network maturation is activity dependent. During the neonatal period, activity is provided by intermittent, spontaneous network activity patterns (SNAP) that occur independently of environment stimuli. Among the neurotransmitters tha…
preprints
2025
置信度 0.74
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Gas-filled microbubbles have been extensively used as contrast agents for ultrasound therapies and have recently been explored as microrobots. When exposed to an intense acoustic wave, microbubbles oscillate and scatter the sound field, leading to assembly and…
preprints
2025
置信度 0.74
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Abstract Background: Ageing is associated with a loss of fluid intelligence and motor functions which hamper independence and quality of life. Training in a musical instrument can improve fluid intelligence and executive function (EF) in older non-musicians bu…
preprints
2025
置信度 0.74
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Interoception, the capacity to sense, perceive, and metacognitively appraise viscerosensory and homeostatic signals, is a growing focus in psychology and psychiatry. Adaptive psychophysical tasks now allow quantification of perceptual sensitivity, bias, and pr…
preprints
2025
置信度 0.74
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Substance use disorder (SUD) stands as a critical public health concern, contributing to substantial morbidity, mortality and societal costs. The effects of SUD on structural brain changes have been well documented. However, the neural mechanisms underlying SU…
preprints
2025
置信度 0.74
-
Cardiovascular disease is the leading cause of death, demanding new tools to improve mechanistic understanding and overcome limitations of stem cell and animal-based research. We introduce T-World, a highly general virtual model of human ventricular cardiomyoc…
preprints
2025
置信度 0.74
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Abstract Hearing loss is a pervasive global health challenge with profound impacts on communication, cognitive function, and quality of life. Recent studies have established age-related hearing loss as a significant risk factor for dementia, highlighting the i…
preprints
2025
置信度 0.74
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Cortical processing depends critically on the precise modulation of excitatory activity by a diverse population of GABAergic interneurons. Among these, neuron-derived neurotrophic factor-expressing (NDNF+) interneurons have been proposed to be "master regulato…
preprints
2025
置信度 0.74
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Summary In goal-directed behavior, cognitive control calls for representation of current state, goal state, and current move, often with hierarchical organization into a series of steps or subgoals. In the human brain, a network of “multiple-demand” or MD regi…
preprints
2025
置信度 0.74
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Direct electrical stimulation of the brain via cortical visual neuroprostheses is a promising approach to restore basic sight for the visually impaired by inducing a percept of localized light called ‘phosphenes’. Apart from the challenge of condensing complex…
preprints
2025
置信度 0.74
-
Glioblastoma is the most lethal primary brain tumor, driven by complex interactions between plastic malignant cells and a diverse tumor microenvironment. Despite advances in single-cell profiling, how genomic drivers and the tumor microenvironment interact to …
preprints
2026
置信度 0.74
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Light field microscopy (LFM) enables volumetric, high throughput functional imaging. However, the computational burden and vulnerability to scattering limit LFM’s application to neuroscience. We present a light-field strategy for volumetric, scattering-mitigat…
preprints
2025
置信度 0.74
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Summary Ultrastructural changes of mitochondria are closely associated with metabolic dysfunction, leading to a variety of human disorders. These changes can be visualized by pan-Expansion Microscopy (pan-ExM), a 3D microscopy technique requiring only standard…
preprints
2025
置信度 0.74
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Spatial proteomics measures multiple proteins in situ , capturing tissue complexity. However, cell classification in densely packed tissues remains challenging due to the lack of efficient classification algorithms, annotation tools, and high-quality labeled d…
preprints
2025
置信度 0.74
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Negative symptoms in schizophrenia, particularly motivational deficits, pose significant challenges to treatment and recovery. Despite their profound impact on functional outcomes, these symptoms remain poorly understood and inadequately addressed by current i…
preprints
2025
置信度 0.74
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Atypical sensory processing in neurodevelopmental disorders contributes to cognitive, social, and behavioural disruptions, yet underlying neurophysiological mechanisms remain unclear. Using a mouse model of SYNGAP1 haploinsufficiency (HET), a common monogenic …
preprints
2025
置信度 0.74
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Abstract Dopaminergic neurons modulate movement, motivation, and learning by dynamically regulating dopamine release across distributed neural circuits. However, existing genetically encoded dopamine sensors lack the sensitivity and resolution to capture the f…
preprints
2025
置信度 0.74
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Primate societies rely on the production and interpretation of social signals, in particular those displayed by the face. Facial movements are controlled, according to the dominant neuropsychological schema, by two separate circuits, one originating in medial …
preprints
2025
置信度 0.74
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Synthetic biology aims to engineer or re-engineer living systems. To achieve increasingly complex functionalities, it is beneficial to use higher-level building blocks. In this study, we focus on oscillators as such building blocks, propose novel oscillator-ba…
preprints
2025
置信度 0.74
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Objects in real-world scenes are often poorly or partially visible, for example because they are occluded or appear in the periphery. An additional challenge of real-world vision is that it is dynamic, causing the appearance of objects (e.g., their size and or…
preprints
2025
置信度 0.74
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Population receptive field (pRF) mapping is a fundamental technique for understanding retinotopic organization of the human visual system. Since its introduction in 2008, however, its scalability has been severely hindered by the computational bottleneck of it…
preprints
2025
置信度 0.74
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The retina encodes a broad range of stimuli, adapting its computations to features like brightness, contrast, or motion. However, it is unclear to what extent it also adapts to spatial frequency content – as theories of efficient coding would predict – for ins…
preprints
2025
置信度 0.74
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Abstract Background : People with anorexia nervosa (AN) show deficiencies with recalling specific details of autobiographical memories (AM). This may interfere with wider processes of self-narrative construction and identity building, which are a fundamental p…
preprints
2025
置信度 0.74
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Collagens are fundamental components of extracellular matrices, requiring precise intracellular post-translational modifications for proper function. Among the modifications, prolyl 4-hydroxylation is critical to stabilise the collagen triple helix. In humans,…
preprints
2025
置信度 0.74
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Abstract Tracking emotion fluctuations in adolescents’ daily lives is essential for understanding mood dynamics and identifying early markers of affective disorders. This study examines the potential of text-based approaches for emotion prediction by comparing…
preprints
2025
置信度 0.74
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Most human tissue collected in clinic for diagnosis of pathology is formalin fixed and paraffin embedded or snap frozen, both of which destroy ultrastructure, making them unsuitable for clinical research requiring high resolution imaging. For diagnosis of some…
preprints
2025
置信度 0.74
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Social coordination in primates relies on parieto-frontal networks encoding self- and others’ actions. These areas send convergent projections to the putamen, but its role in representing self- and others’ actions remains unknown. We recorded neuronal activity…
preprints
2025
置信度 0.74
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Gait deficits present an unresolved therapeutic challenge in Parkinson’s Disease. At the behavioral level, symptoms exhibit heterogeneity, including bradykinesia and hypokinesia during cyclical limb movement, as well as sudden interruptions in the gait sequenc…
preprints
2025
置信度 0.74
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Abstract Background The regulatory molecule Human Leukocyte Antigen F (HLA-F) has been implicated in trophoblast proliferation during pregnancy, and reduced levels of this antigen have been identified in trophoblast cells of patients with preeclampsia. This st…
preprints
2025
置信度 0.74
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BACKGROUND: Routinely collected health data, such as that held by the United Kingdom (UK) National Health Service/Health and Social Care (collectively "NHS"), has important research uses, but its appropriate use requires public trust and transparency. Commerci…
preprints
2025
置信度 0.74
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Humans start new friendships and social connections throughout their lives and such relationships foster mental and physical well-being. While friendship initiation may depend on alignment of subtle and complex personal variables, here we investigated whether …
preprints
2025
置信度 0.74
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The cerebral cortex orchestrates complex cognitive functions, yet how its distinct temporal lineages are molecularly patterned during development remains unresolved. Here, we integrate single-cell transcriptomics and chromatin accessibility, together with geno…
preprints
2025
置信度 0.74
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Abstract Some of the most dramatic examples of neuroplasticity in the human brain follow congenital sensory deprivation, though we have limited understanding of the plasticity mechanisms driving such large-scale remapping. Hand loss due to congenital limb diff…
preprints
2025
置信度 0.74
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High-channel-count neuroprostheses could one day restore functional vision in blind individuals by delivering electrical pulses to electrodes in the visual cortex that elicit perceptions known as ‘phosphenes’. However, if a high number of electrodes are used, …
preprints
2024
置信度 0.74
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Abstract Commissioning of innovations in healthcare is a complex socio-technical process, ideally informed by high quality evidence. However, evidence is not always prepared and presented in a format usable for commissioning decisions. Agile methodology, combi…
preprints
2025
置信度 0.74
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ABSTRACT Although the fundamental architecture of metazoan nervous systems is typically established in the embryo, substantial numbers of neurons are added during post-natal development while existing neurons expand in size, refine connectivity, and undergo ad…
preprints
2025
置信度 0.74
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pubmed
Amrani H, Micucci D, Napoletano P
2025
置信度 0.82
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Critical to rigor in neurodegeneration research is the accurate and unbiased assessment of degenerative phenotypes, where stereology remains the gold standard, yet its widespread adoption is hindered by the high cost of proprietary systems. We developed OPEN-S…
europepmc
2025
置信度 0.80
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Brain-controlled systems have experienced significant advancements in overall performance, largely driven by continuous optimization and innovation in electroencephalography (EEG) acquisition experimental paradigms and decoding algorithms. However, their appli…
europepmc
2025
置信度 0.80
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Auditory attention decoding based on steady-state motion auditory evoked potential (SSMAEP) offers a promising pathway for developing auditory brain-computer interface (BCI) driven by auditory selective attention. However, achieving high decoding performance w…
europepmc
2025
置信度 0.80
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pubmed
Michelini S, Alomari AA, Fraschetti F, Carpineta E 等
2026
置信度 0.82
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ObjectiveThis systematic review evaluates the use of cognitive load measurement methods in usability testing across diverse software interfaces. It provides guidance for researchers and practitioners by proposing a framework for selecting appropriate cognitive…
europepmc
2026
置信度 0.80
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BACKGROUND: Brain-computer interfaces (BCIs) are increasingly used to support rehabilitation and assistive communication. Individual traits such as age, cognitive function, attention, and mental state have been linked to variability in BCI performance. However…
pubmed
Xinyue Niu, Min Yuan, Dong Wang, Niu X 等
2025
置信度 0.82
Brain–computer interfaceUsabilityCognitionInterface (matter)Human–computer interaction
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Neuroimplants are likely major technological breakthroughs of the next decade with the potential for unprecedented social impact. In addition to attractive and miracle-looking possibilities, the major obstacle for the industry is complicated, unpredictable, an…
pubmed
Mikhail Paveliev, Anastasiia Melnikova, Anton A. Egorchev, Vladimir Parpura 等
2025
置信度 0.82
NeuroscienceGlial scarSelf-healing hydrogelsRegeneration (biology)Medicine
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pubmed
Catherine Chan KL, Yan C, Wang X, Huang S 等
2026
置信度 0.82
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pubmed
Machhi V, Shah A
2026
置信度 0.82
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Inner speech (IS), or imagined speech without overt articulation, is a promising target for brain-computer interfaces (BCIs) aimed at restoring communication in individuals with severe speech impairments, such as locked-in syndrome. Foundation models (FMs), ty…
pubmed
Sümer-Arpak E, Saini R, Chakladar DD, Varun SK 等
2026
置信度 0.82
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The Beckman Institute for Advanced Science of Technology at the University of Illinois Urbana-Champaign was established in 1989 with the generous support of the Arnold and Mabel Beckman Foundation. It was built to break through disciplinary boundaries and prod…
europepmc
2025
置信度 0.80
-
The foreign body reaction to implanted electrodes in the brain has long been recognized as a major challenge impacting the performance and reliability of indwelling neurotechnologies. Spatially resolved transcriptomic approaches have enabled high-resolution ma…
pubmed
Gupta B, Chakraborty A, Saxena A, Moore MG 等
2026
置信度 0.82
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pubmed
Liu C, Han J, Wang Y, Liang X 等
2026
置信度 0.82
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pubmed
Skierkowska M, Piernicki T, Seifzadeh S, Cimbalnik J 等
2025
置信度 0.82
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The detection and interpretation of brain signals are crucial for advancing brain-computer interface (BCI) technologies. Local field potential (LFP) signals, reflecting synchronized neuronal ensemble activity, offer insights into coordinated neural function. I…
pubmed
Wang Y, Luo J, Zhang C, Jin Z 等
2026
置信度 0.82
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Oropharyngeal dysphagia affects over half of neurological and oncological populations, yet rehabilitation is constrained by a global therapist shortage that human-AI collaboration has not demonstrably addressed. Here we report a systematic review of 31 studies…
europepmc
2026
置信度 0.80
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Objective Deep brain stimulation (DBS) targeting the lateral habenula (LHb) is a promising therapy for treatment-resistant depression (TRD) but its clinical effect has been variable, which can be improved by adaptive DBS (aDBS) guided by a neural biomarker of …
europepmc
2025
置信度 0.80
-
In recent years, there has been a significant increase in research activity on electroencephalography (EEG)-based motor imagery brain-computer interfaces (MI-BCI) in the field of deep learning. However, despite achieving high accuracy, the size of models is in…
pubmed
Chen Z, Lu Y, Xu X
2025
置信度 0.82
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Background: Brain-computer interface (BCI) closed-loop systems have emerged as a promising tool in health care and wellness monitoring, particularly in neurorehabilitation and cognitive assessment. With the increasing burden of neurological disorders, includin…
pubmed
Christopher Williams, Fahim Islam Anik, Md Mehedi Hasan, Juan Rodriguez-Cardenas 等
2025
置信度 0.82
NeurorehabilitationPreprintInterface (matter)Computer scienceNeural engineering
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BACKGROUND: Upper limb dysfunction is a common and debilitating consequence of stroke, severely affecting patients’ activities of daily living and quality of life. Motor imagery (MI) has emerged as a promising rehabilitation technique, and its combinati…
pubmed
Xi L, Liu Q, Li H, Li W 等
2026
置信度 0.82
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Introduction Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease that leads to severe motor impairment, including loss of communication ability, and ultimately death. Communication brain computer interfaces (cBCIs) have the potential to r…
europepmc
2026
置信度 0.80
-
europepmc
2025
置信度 0.80
-
Brain-computer interface (BCI) technology for emotion recognition holds significant potential for future applications in the treatment of refractory emotional disorders. Stereo-electroencephalography (SEEG), being less invasive, can precisely record neural act…
europepmc
2025
置信度 0.80
-
E/MEG source imaging (ESI) provides non-invasive measurements of brain activity with high spatial and temporal resolution. In particular, the wearability and portability of EEG make it an attractive area of research beyond the biomedical communities, especiall…
europepmc
2025
置信度 0.80
-
europepmc
2025
置信度 0.80
-
The development of high-performance neural interfaces is critical for advancing brain-machine communication and treating neurological disorders. A major challenge in neural electrode design is achieving a seamless biological-electronic interface with optimized…
europepmc
2025
置信度 0.80
-
Over the past 14 years, eye-tracking technology has emerged as a transformative tool in psychological research, offering insights into cognitive processes, emotional responses, and behavioral patterns. This narrative review synthesizes advancements in eye-trac…
europepmc
2026
置信度 0.80
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The rapid advancement of medical brain-computer interface (BCI) technology necessitates the transformation and upgrading of traditional governance paradigms urgently. China, the United States, and the European Union hold prominent positions in the global medic…
europepmc
Rongrong Zhu, Yangyang Zhao, Yetong Li
2025
置信度 0.80
European unionCorporate governancePolitical scienceEmpowermentMulti-level governance
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Brain-computer interface (BCI) systems, and particularly electroencephalogram (EEG) based BCI systems, have become more widely used in recent years and are utilized in various applications and domains ranging from medicine and marketing to games and entertainm…
pubmed
Landau O, Nissim N
2025
置信度 0.82
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Motion-onset visual evoked potential (mVEP) are transient brain responses triggered by sudden motion stimuli and are widely used in brain-computer interface (BCI) systems. However, the inherently weak nature of mVEP signals poses a significant challenge to ach…
pubmed
Zhang H, Xie J, Yu H, Du F 等
2025
置信度 0.82
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Brain injury models with a supramillimeter resolution are not feasible to provide spatially detailed strains at or below millimeter scales, especially in regions of convoluted geometry such as at the gray/white matter interface. Furthermore, non-conforming mes…
pubmed
Molchanov D, Zhang C, Lin N, Ji S 等
2025
置信度 0.82
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Pupillary-computer interface (PCI) refers to a novel interaction modality that leverages pupil size variations elicited by changes in visual stimulus brightness. The PCI based on the pupillary light reflex (PLR) induced by binary-coded visual stimuli was propo…
europepmc
2025
置信度 0.80
-
Brain-computer interfaces (BCIs) provide a pathway to assistive technologies such as brain-controlled wheelchairs, yet accurate motor imagery (MI) classification from electroencephalography (EEG) remains challenging due to noise and subject variability. In thi…
pubmed
Upadhyay PK, Chandra KA
2025
置信度 0.82
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Brain-Computer Interfaces (BCIs) enable the translation of brain activity into executable commands, with Motor Imagery (MI)- based systems gaining prominence for their intuitive and non-invasive control. Electroencephalography is widely used due to its portabi…
pubmed
Shirodkar VR, Reddy Edla D, Kumari A, Afonso MM
2025
置信度 0.82
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With the advancement in neurotechnology the human-machine interaction has been redefined, 11 specifically with progress in brain-computer interface (BCI) systems (Zhang et al. 2023). By 12 translating neural activity directly into machine-executable commands, …
europepmc
2026
置信度 0.80
-
Neurorehabilitation poses a crucial problem in clinical recovery tasks, particularly for individuals with poor motor functions and neurological impairments, and problems in activities of daily living (ADL). To resolve this, we design a novel model, Rehab-DRLX,…
europepmc
2026
置信度 0.80
-
Functional magnetic resonance imaging (fMRI) opens a window on observing spontaneous activities of the human brain in vivo. However, the high complexity of fMRI signals makes brain functional representations intractable. Here, we introduce a state decompositio…
europepmc
2025
置信度 0.80
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Rehabilitation faces a scale problem: millions who could benefit lack timely, effective services. Artificial intelligence (AI) and device-based modalities (e.g., robotics and VR) can extend reach and personalise care when validated, yet decision-makers lack a …
pubmed
Abdalla N, El Arab RA, Abdrbo A, Almari M 等
2026
置信度 0.82
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Brain-Computer Interface (BCI), Brain Function Detection (BFD), and Brain Stimulation (BS) are three pivotal technological domains in neuroscience and neuroengineering. Each plays a critical role in fundamental research, clinical applications, and human-comput…
pubmed
Xue Y, Chen Y, Wang F, Zhao L 等
2025
置信度 0.82
-
pubmed
Jia Y, Lian Q, Wang L, Wang Y 等
2025
置信度 0.82
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Brain-computer interface (BCI) technology has emerged as a crucial interdisciplinary advancement in the field of neuropsychiatric disease treatment. With the global rise in the prevalence of neurological and psychiatric disorders, which impose a substantial bu…
pubmed
Feng Y, Zhang W, Chen J, Wu H 等
2026
置信度 0.82
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Virtual reality (VR) has emerged as a key technology for immersive human-computer interaction, where sensing systems are essential for enabling natural, adaptive, and multisensory experiences. However, the scientific landscape of sensing techniques in VR remai…
europepmc
2026
置信度 0.80
-
Background The paradigms greatly influence the performance of motor imagery (MI)-based brain-computer interfaces (BCI) by guiding subjects to imagine. How to make the guidance clear and intuitive is important for MI-BCI to improve performance. New methods This…
europepmc
2025
置信度 0.80
-
Objective. To enhance frequency recognition in steady-state visual evoked potential (SSVEP)-based brain-computer interfaces (BCIs), particularly under short data acquisition and complex environmental conditions. Approach. We propose multi-stimulus discriminant…
europepmc
2025
置信度 0.80
-
Background Brain-computer interfaces (BCIs) offer a promising avenue for individuals with severe motor disabilities to interact with the world. By decoding brain signals, BCIs can enable users to control devices and communicate thoughts. However, challenges su…
europepmc
2025
置信度 0.80
-
pubmed
Fu X, Jiang W, Liu R, Müller-Putz GR 等
2026
置信度 0.82
-
Electrocorticography (ECoG) holds considerable promise for neural signal monitoring with high spatiotemporal resolution. However, conventional rigid ECoG electrodes are often hampered by poor mechanical compliance and insufficient resistance to biofouling, lea…
pubmed
Xiang Y, He X, Cheng T, Zhu W 等
2025
置信度 0.82
-
Functional near-infrared spectroscopy (fNIRS) has emerged as a promising neuroimaging tool for assessing patients with disorders of consciousness (DoC). While functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) have advanced the detec…
pubmed
Kazazian K, Kolisnyk M, Gupta G, de Jeu J 等
2026
置信度 0.82
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Inner speech decoding is the process of identifying silently generated speech from neural signals. In recent years, this candidate technology has gained momentum as a possible way to support communication in severely impaired populations. Specifically, this ap…
pubmed
Almufareh MF, Kausar S, Humayun M, Tehsin S 等
2025
置信度 0.82
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Purpose This work aims to increase the classification accuracy of motor imagery-based brain-computer interface (MI-BCI) by employing Cross-Frequency Coupling (CFC) and using spontaneous EEG as an input for the features to increase the system's robustness. Meth…
europepmc
2025
置信度 0.80
-
High-frequency steady-state visual evoked potential-based brain-computer interface (SSVEP-BCI) systems offer improved user comfort but suffer from reduced performance compared to their low-frequency counterparts, limiting their practical application. To addres…
europepmc
2025
置信度 0.80