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Abstract Background Randomized placebo‐controlled trials (RCTs) are the gold standard to evaluate efficacy of new drug treatments for Alzheimer’s disease. For example, the United States FDA approved the brain amyloid‐targeting drug lecanemab following CLARITY …
openalex
Daniel Andrews, D. Louis Collins, the Alzheimer’s Disease Neuroimaging Initiative
2024-12-01
置信度 0.72
Randomized controlled trialObservational studyMedicinePlaceboClinical trial
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Digital twin (DT) technology can potentially boost project performance and decision-making across various industries, including construction. However, the Malaysian construction sector encounters various barriers to its implementation. This paper aims to explo…
openalex
Muneera Esa, Praveena Munianday, Jahanzeb Asim
2024-12-25
置信度 0.72
BusinessIndustrial organizationConstruction engineeringEngineering
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This paper provides the complete details of current challenges and solutions in the cybersecurity of cyber-physical systems (CPS) within the context of the IIoT and its integration with edge computing (IIoT-edge computing). We systematically collected and anal…
pubmed
Tamara Zhukabayeva, Lazzat Zholshiyeva, Nurdaulet Karabayev, Shafiullah Khan 等
2025 Jan 2
置信度 0.82
Computer securityComputer scienceEdge computingContext (archaeology)Industrial Internet
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Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomar…
openalex
Jean Bousquet, Mohamed H. Shamji, Josep M. Antó, Holger J. Schünemann 等
2023-04-12
置信度 0.72
MedicineAsthmaAllergen immunotherapyQuality of life (healthcare)Allergy
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Simulation is a fundamental tool in developing autonomous vehicles, enabling rigorous testing without the logistical and safety challenges associated with real-world trials. As autonomous vehicle technologies evolve and public safety demands increase, advanced…
openalex
Yuankai He, Hanlin Chen, Weisong Shi
2024-05-02
置信度 0.72
Crystal twinningComputer scienceMaterials scienceMetallurgyMicrostructure
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Digital Twins has transformed the way an urban environment can be managed and operated by developing digital twins of physical systems through real-time emulation. With the urbanization phenomenon occurring around cities, which is accompanied by population gro…
openalex
Vijayanand Selvaraj
2025-07-26
置信度 0.72
ImplementationUrbanizationSustainabilitySustainable developmentUrban planning
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The modern stage of technology development allows us to create anthropogenic systems that feature a fundamentally new level of complexity compared to existing systems, which for the most part are multilevel heterogeneous distributed systems, which include anth…
openalex
Alexander Vodyaho, Nataly Zhukova, V. Ya. Ananeva
2024-01-01
置信度 0.72
Cyber-physical systemComputer securityComputer scienceInternet privacyOperating system
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The increasing complexity of urban infrastructure necessitates more efficient and proactive maintenance strategies. Traditional maintenance approaches often rely on reactive measures, leading to increased costs, unplanned downtime, and potential structural fai…
openalex
Dita Diana, Putri Anindita, Anggi Angga Mukti
2025-03-01
置信度 0.72
Predictive maintenanceSustainabilityComputer scienceRisk analysis (engineering)Predictive analytics
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This study uses a wind turbine case study to showcase an architecture for implementing a distributed digital twin in which all important aspects of a predictive maintenance solution in a DT use a fog computing paradigm, and the typical predictive maintenance D…
preprints
Ibrahim Abdullahi, Stefano Longo, Mohammad Samie
2024
置信度 0.74
Predictive maintenanceDistributed manufacturingComputer scienceBusinessManufacturing engineering
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openalex
José Monteiro, João Barata
2025-01-01
置信度 0.72
Environmental scienceSoil waterSoil science
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This article examines the applicability and impact of digital twin technologies across the agri-food sector, from field operations to postharvest logistics. Building on a structured review of recent literature and industry cases, we synthesize how physics-base…
openalex
Aleksandr Berus, Anastasia OSADCHAYA
2025-12-03
置信度 0.72
InteroperabilityContext (archaeology)Computer scienceSustainabilityQuality (philosophy)
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Europe prioritizes energy efficiency for sustainable development and climate action, with buildings consuming 40% of the EU’s energy and contributing over 30% of CO 2 emissions. To address this, the EU implements policies targeting energy efficiency across sec…
openalex
José L. Hernández, Ignacio de Miguel, Fredy Vélez, Pablo Marcos 等
2024-01-01
置信度 0.72
Computer scienceEfficient energy useEnergy (signal processing)TelecommunicationsElectrical engineering
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The increasing number of aging bridges underscores the need for efficient maintenance to enhance safety and reduce costs. This paper explores integrating digital twin technologies into bridge management to improve maintenance efficiency and accuracy. A 15-year…
openalex
Ali Sabzi Khoshraftar, Berend Jan van der Zwaag, Duc V. Le, Özlem Durmaz-Incel
2025-07-22
置信度 0.72
Bridge (graph theory)Computer scienceMedicineInternal medicine
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preprints
2026
置信度 0.74
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Rapid urbanization and intensifying climate risks are placing unprecedented pressure on cities to transition toward sustainable and resilient models. Achieving Sustainable Development Goals (SDGs) 11 (Sustainable Cities and Communities) and 13 (Climate Action)…
europepmc
Toqeer Ali Syed, Ali Akarma, Muhammad Tayyab Naqash, Danial Hameed 等
2026
置信度 0.80
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Predicting plant phenotypes from genomic data requires models that bridge molecular regulation and organ-scale morphogenesis. We introduce BioOS, a computational runtime in which plant behavior - cell division, differentiation, and elongation - emerges from th…
preprints
Emeline AUGER, Mickael Gandecki, Charly Delarche, Francois Xavier Heng
2026
置信度 0.74
-
europepmc
2026
置信度 0.80
-
Abstract Pipeline strainers are essential components in all fluid systems offshore, whose prime function is to filter out debris and particulates from the flow streams to protect the downstream equipment. Efficiency decreases owing to clogging and fouling and …
preprints
Nsini Ignatius Udo
2026
置信度 0.74
-
preprints
2026
置信度 0.74
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This study investigates the role of data analytics and digital twin technologies in enhancing smart factory performance, focusing on their impact on operational efficiency, product quality, and organizational transformation. The purpose was to explore how the …
preprints
Isabelle Warwick
2026
置信度 0.74
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Abstract The Digital Pedon (DP) is an open-source Python framework that represents a soil profile as a continuously updated digital twin, bridging three persistent gaps in soil science: disconnected models and observations, cross-database interoperability, and…
preprints
Ali Youssef, Nasem Badreldin
2026
置信度 0.74
-
europepmc
2026
置信度 0.80
-
preprints
2026
置信度 0.74
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
preprints
2026
置信度 0.74
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
Front Running Simulation (FRS) is a Digital Twin–enabled capability that continuously replicates the current state of physical systems, predicts probable future states, and identifies actions to navigate to defined goals while minimizing the expenditure of sca…
preprints
Michael Grieves
2026
置信度 0.74
-
preprints
2026
置信度 0.74
-
Abstract To address key challenges in low-altitude airspace management, such as high dynamic complexity, significant safety risks, and information fragmentation, a digital twin-based methodology for low-altitude airspace computation and analysis is proposed in…
preprints
Zhenghan HE, Weibin ZHANG, Peng DU, Zhiyong LIU
2026
置信度 0.74
TrajectoryComputer scienceKey (lock)ComputationKalman filter
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Coordinating Vehicle to Everything (V2X) services across multiple building microgrids remains challenging due to scalability limitations, lack of convergence guarantees, and inadequate battery degradation consideration. This paper develops a hierarchical Cogni…
preprints
Mohammed Mousa
2026
置信度 0.74
-
europepmc
Bondhon Paul, MD AZIZUL HAKIM ABIR, RAFIUR RAHMAN, MD TANVIR AHMED TOWFIQ 等
2026
置信度 0.80
Systematic reviewIndustry 4.0Computer scienceGenerative grammarConceptual framework
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preprints
2026
置信度 0.74
-
Abstract The development of solid-state electrolytes (SSEs) with high ionic conductivity remains a critical challenge for next-generation batteries. Traditional trial-and-error discovery methods are time-consuming, and computational screening approaches often …
preprints
2026
置信度 0.74
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Abstract Background . Cost overruns and budget unpredictability remain persistent challenges in civil infrastructure delivery, particularly where static, document-based budgeting is decoupled from real-time site conditions. Digital twins (DT), understood as dy…
europepmc
PAUL RICARDO PRUDENCIO GALVEZ
2026
置信度 0.80
-
preprints
2026
置信度 0.74
-
preprints
2026
置信度 0.74
-
preprints
2026
置信度 0.74
-
preprints
2026
置信度 0.74
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
preprints
2026
置信度 0.74
-
europepmc
2026
置信度 0.80
-
Abstract Digital twins of biological systems have been proposed as a framework for personalized medicine; however, existing implementations in oncology operate at the tissue or population scale with parameters derived from textbook kinetics rather than patient…
preprints
John D. Mayfield
2026
置信度 0.74
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Abstract This paper presents the development of a low-cost, cyber-physical inventory management system, serving as Volume I of a multi-stage research project. The study focuses on the foundational prototype development and baseline system feasibility of utiliz…
preprints
Karthik .V.S
2026
置信度 0.74
-
preprints
2026
置信度 0.74
-
preprints
2026
置信度 0.74
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
preprints
2026
置信度 0.74
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
Linking synaptic-level perturbations to distributed brain-network dynamics remains a central challenge for understanding and treating mental illness. Although recent whole-brain models can reproduce individual brain activity patterns, they largely function as …
preprints
Yunman Xia, Songjun Peng, Juergen Dukart, Y. Xie 等
2026
置信度 0.74
NeuroscienceNeuroanatomyPsychologyPopulationNetwork dynamics
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preprints
2026
置信度 0.74
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Polymer composites used in structural applications are frequently exposed to combined thermal and moisture environments, which gradually degrade their mechanical performance over time. Predicting this behavior remains challenging due to the complex interaction…
preprints
Aswin Karakadakattil
2026
置信度 0.74
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preprints
2026
置信度 0.74
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Wildfire spread prediction demands hyper-local accuracy at scales unattainable by traditional physics-based models or coarse satellite observations. This paper introduces a novel Digital Twin AI framework leveraging 5G IoT mesh networks to deliver real-time, 1…
preprints
Sindhuja A
2026
置信度 0.74
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Abstract This paper presents a Digital Twin–based Artificial Intelligence (DT–AI) framework for real-time mental health monitoring in academic environments. The system combines multimodal data such as facial expressions, voice tone, physiological signals and b…
preprints
Amanullah Quamer, Harshita ., Khalid Hafiz Mir
2026
置信度 0.74
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preprints
2026
置信度 0.74
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preprints
2026
置信度 0.74
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preprints
2026
置信度 0.74
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preprints
2026
置信度 0.74
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preprints
2026
置信度 0.74
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preprints
2026
置信度 0.74
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Abstract Traditional approaches to anticancer dosing typically rely on fixed protocols that often overlook how patients respond differently to treatment. This can limit both effectiveness and safety. In this work, we introduce a digital twin–reinforcement lear…
preprints
Atantra Das Gupta
2026
置信度 0.74
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Abstract We present a physics-inspired classical digital twin of the cell: a graph neural network constrained to a compartmental, multi-clock port-Hamiltonian form, with parameters learned from multi-omic measurements. The port-Hamiltonian structure is a model…
europepmc
Dibakar Sigdel, Namuna Panday
2026
置信度 0.80
-
preprints
2026
置信度 0.74
-
preprints
2026
置信度 0.74
-
europepmc
2026
置信度 0.80
-
preprints
2026
置信度 0.74
-
preprints
2026
置信度 0.74
-
preprints
2026
置信度 0.74
-
europepmc
2026
置信度 0.80
-
Digital Twin (DT) technology has become a critical component of smart city evolution, providing real-time analytics, predictive modelling, and operational efficiency enhancements. The goal of this paper is to explore the opportunities and barriers for a city-w…
preprints
Manolya Kavakli-Thorne
2026
置信度 0.74
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preprints
2026
置信度 0.74
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
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Abstract Background Even with optimal secondary prevention, the residual risk of recurrent ischemic stroke remains clinically significant: epidemiological data indicate that approximately one in six patients experiences a recurrent ischemic event within five y…
preprints
Shiyang Liu, Meixiang Sun, Hui Liu, Yu Wang 等
2026
置信度 0.74
-
europepmc
2026
置信度 0.80
-
Reliable and resilient communication systems are essential for first responders, enabling quick coordination and effective emergency responses. However, traditional communication networks often encounter congestion, interoperability problems, and failures duri…
preprints
Dileesh Chandra Bikkasani
2026
置信度 0.74
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preprints
2026
置信度 0.74
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Abstract Accurately understanding the spatiotemporal distribution of key hazardous factors in fire scenes assists firefighters in making more informed decisions. This study developed a hybrid deep learning framework combining Long Short-Term Memory networks (L…
preprints
Zenghui Liu, Guanhua Qu, Ming Yan, Lan Wang 等
2026
置信度 0.74
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europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
preprints
2026
置信度 0.74
-
europepmc
2026
置信度 0.80
-
Abstract Achieving zero-defect production in five-axis machining of aerospace titanium alloys remains difficult because process dynamics change continuously as tools wear, thermal fields evolve, and vibration modes shift with tool orientation. Conventional dig…
europepmc
MD AZIZUL HAKIM ABIR, BONDHON PAUL
2026
置信度 0.80
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preprints
2026
置信度 0.74
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Abstract Descolmatation (desilting) of Andean rivers and lagoons in Peru routinely encounters sediment that is jointly loaded with heavy metals and organic pollutants, a co-contamination pattern that conventional single-binder, single-contaminant remediation d…
europepmc
PAUL RICARDO PRUDENCIO GALVEZ
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
Abstract We report an ns-3 simulation of an IoBT network built to quantify IFF reliability under terrain-heterogeneous LoRaWAN propagation. The testbed models a 10 × 10 km battlespace with 200 Class A end-devices, hexagonal gateway grids at five inter-gateway …
preprints
Anurag Dhar, Rachit Ahluwalia, Santosh Kumar
2026
置信度 0.74
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80