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• Identifiability-Guided Assessment of Digital Twins in Alzheimer’s Disease Clinical Research and Care
  Digital twins - personalized, data-driven computational models - are emerging as a powerful paradigm for representing and predicting disease trajectories at the individual level. These models have the potential to support diagnosis, monitor disease evolution, …
  preprints J. J. Jiang, Jeffrey R. Petrella, Wenrui Hao, the Alzheimer’s Disease Neuroimaging Initiative 2025 置信度 0.74 IdentifiabilityDiseasePsychologyMedicineEconometrics
• Light-Perception-Based Interactive Control of an Underwater Digital Twin Hand
  preprints 2025 置信度 0.74
• Digital Twin-Based Learning Analytics with Fog Computing and LLAMA
  preprints 2025 置信度 0.74
• Mathematical Modeling of Elastic-Thermodynamic Interaction During Metal Turning On Metal-Cutting Machines
  preprints 2025 置信度 0.74
• Temporal Modeling for Domain-Invariant Fault Diagnosis in Robotics Digital Twin Systems
  Fault diagnosis in robotics frequently encounters obstacles due to the scarcity of labeled real-world data and the disparities between simulated and physical systems. Digital twin technology mitigates data limitations by producing simulated datasets; however, …
  preprints Pranjal Kumar 2025 置信度 0.74
• Digital Twin and Machine Learning Approaches for Renewable Energy System Optimization
  Abstract This research introduced a combined digital twin and machine learning framework aimed at enhancing biofuel conversion efficiency and energy return on investment (EROI), while concurrently simulating battery degradation dynamics for sustainable energy …
  preprints IDOWU OLUGBENGA ADEWUMI, Victoria Bola Oyekunle, Waheed Azeez Ajani 2025 置信度 0.74
• Developing and Validating a Sectoral Qualifications Framework for the Copper Industry: Integrating Digital and Green Competences for a Sustainable Workforce
  preprints 2025 置信度 0.74
• WITHDRAWN: Theoretical Analyses and Performance Comparison of Physics-Based, Data-Driven, and Hybrid Models for Digital Twin Applications in Manufacturing
  Abstract Digital twins (DT) are increasingly important in modern manufacturing systems to extend the physical system’s capabilities and improve manufacturing key performance indicators. Nevertheless, selecting the most effective modeling approach for DT servic…
  europepmc Marcel Wagner, Fábio J. P. Sousa, Matthias Klar, Jan C. Aurich 2025 置信度 0.80
• AI-Powered Digital Twin Co-Simulation Framework for Climate-Adaptive Renewable Energy Grids
  Climate change is accelerating the frequency and intensity of extreme weather events, posing a critical threat to the stability, efficiency, and resilience of modern renewable energy grids. In this study, we propose a modular, AI-integrated digital twin co-sim…
  preprints Kwabena Addo, Musasa Kabeya, Evans Eshiemogie Ojo 2025 置信度 0.74 Renewable energyComputer scienceGridEnvironmental economicsEnvironmental science
• Toward Intelligent and Resilient Public Safety Communications: A Comprehensive Review of FirstNet, 5G, AI, and Emerging Technologies
  preprints 2026 置信度 0.74
• Multiphysics Modeling of Gearbox NVH in Electric Drivetrains: Methods, Tools, and Trends
  europepmc 2026 置信度 0.80
• Optimising recovery from childhood moderate acute malnutrition: a randomized controlled trial
  europepmc 2026 置信度 0.80
• Advances in Deep Learning for Medical Imaging: Foundations, Evolution, and Impact
  preprints 2025 置信度 0.74
• Smartphone-Based Bioelectric Coherence Index for Mental Health Diagnostics: A Digital Twin Study
  preprints 2025 置信度 0.74
• Artificial Intelligence-Based Digital Twins Metaverse to Improve STEM Work Skills and Adaptive Expertise in Higher Education: A Conceptual Framework
  Rapid advances in Artificial Intelligence (AI), Digital Twin (DT) technology, and the Metaverse have created new opportunities for transforming STEM education and workforce preparation. However, existing learning systems remain fragmented and lack an integrate…
  preprints Syarifuddin Syarifuddin, Titus Kurra, Aris Susanto, Hendra Dani Saputra 等 2025 置信度 0.74 MetaverseConceptual frameworkComputer scienceExperiential learningCompetence (human resources)
• Supply Chain Triangulation: A Digital-Resilience Architecture Across Nodes, Data, and Analytics
  preprints 2025 置信度 0.74
• Mapping immersive digital tools in the ICT4Water Cluster: innovation, interoperability and impact.
  preprints 2025 置信度 0.74
• Transmedia Storytelling and Community Consciousness Construction of Grand Canal Intangible Cultural Heritage in Digital Twin Scenarios
  preprints 2025 置信度 0.74
• Organs-on-Chips in Drug Development: Engineering Foundations, Artificial Intelligence, and Clinical Translation
  preprints 2026 置信度 0.74
• A Generative Patient Digital Twin for Sequential Treatment of Oropharyngeal Squamous Carcinomas
  preprints 2025 置信度 0.74
• Digital Twin based Sorting Optimization for Parcel Distribution Centers in Logistics Networks
  Abstract Parcel distribution centers (PDCs) in logistics networks aim to efficiently sort the inbound parcels for downstream destinations via a parcel-sorting system (PSS), by which the parcels are diverted to the assigned grids and packed into bins for outbou…
  preprints Chuan Huang, Wei Zhang, Ran Li, Yuanming Tian 等 2025 置信度 0.74
• Digital Twin-Driven Intrusion Detection for Industrial SCADA: A Cyber-Physical Case Study
  The convergence of operational technology (OT) and information technology (IT) n industrial environments, such as water treatment plants, has significantly increased the attack surface of Supervisory Control and Data Acquisition (SCADA) systems. Traditional in…
  preprints Ali Sayghe 2025 置信度 0.74 SCADACyber-physical systemIntrusion detection systemIntrusionComputer security
• GIANT: AI- and Digital Twin-Based Framework for Proactive and Energy-Efficient Resource Management in HPC Datacenters
  preprints 2025 置信度 0.74
• Twin Transition: Digital Transformation Pathways for Sustainable Innovation
  preprints 2025 置信度 0.74
• Single-cell-level digital twins for preterm birth prevention strategies
  preprints 2025 置信度 0.74
• Next-Generation Space Cardiology: Developing a COMSOL-Enabled Digital Heart Twin for Long-Duration Missions
  preprints 2025 置信度 0.74
• Forecasting Urban Wastewater Microbiome Dynamics Using a Digital Twin Framework
  preprints 2025 置信度 0.74
• Research on digital twin diagnosis model for the thermal-electric field of high-voltage switchgears
  preprints 2025 置信度 0.74
• A Digital Twin of Glimepiride for Personalized and Stratified Diabetes Treatment
  Optimizing glimepiride therapy for type 2 diabetes (T2DM) is challenged by pronounced inter-individual variability in pharmacokinetics. To address this, we developed a whole-body physiologically based pharmacokinetic (PBPK) model as a digital twin of glimepiri…
  preprints Michelle Elias, Matthias König 2025 置信度 0.74
• Developing a digital twin for the ammonia fuelling system structure: A systems approach
  preprints 2025 置信度 0.74
• Beyond Compliance: A Techno-Geopolitical Framework for Scalable AI Resilience in Critical Infrastructure Along the NATO-EU Eastern Flank
  preprints 2025 置信度 0.74
• A Hybrid Metaheuristic Approach for Multi-Objective Load Balancing in Digital Twin-Enabled Cloud Environment
  Abstract The rapid growth of digital twin services is pushing computational resources requirements to unprecedented levels. While cloud computing provides the scalable infrastructure needed to support these computational demands. However, the critical challeng…
  preprints Anand Mishra, Rahul Yadav, Prabhjot Kaur, Shubham Gargrish 等 2025 置信度 0.74 Cloud computingMetaheuristicComputer scienceLoad balancing (electrical power)Distributed computing
• Generating Millions Of Transport Scenarios From A Large Scale Digital Twin
  Abstract In the development of city planning since the middle of the last century, there have been severe difficulties in generating enough plans to test largely because computational methods have not been available to generate a systematic evaluation of their…
  preprints Richard Milton, Michael Batty, Xinyi Liu, Yuet Yung Lung 2025 置信度 0.74
• A Review on Machine Learning Applications in Chance-Constrained Power System Optimization
  preprints 2025 置信度 0.74
• Application of Digital Twin Technology in Smart Agriculture: A Bibliometric Review
  Digital twin technology is reshaping modern agriculture. Digital twins are the virtual replicas of real-world farming systems, which are continuously updated with real-time data, and are revolutionizing the monitoring, simulation, and optimization of agricultu…
  preprints 2025 置信度 0.74
• Musculoskeletal Digital Therapeutics and Digital Health Rehabilitation: A Global Paradigm Shift in Orthopaedic Care
  Musculoskeletal disorders (MSDs) affect over 1.7 billion people globally and rep-resent the leading cause of disability worldwide. Conventional rehabilitation strate-gies face challenges including limited accessibility, suboptimal adherence, and lack of person…
  preprints Youn Kyu Lee, Tae Hyung Kim, Jong Ho Kim 2025 置信度 0.74 Digital healthPsychological interventionRehabilitationParadigm shiftMedicine
• Embedded real-time analysis of continuous casting for machine-supported quality optimisation
  preprints 2025 置信度 0.74
• Genotype-specific Digital Twins for Arrhythmia Ablation Targeting in Arrhythmogenic Right Ventricular Cardiomyopathy
  preprints 2025 置信度 0.74
• Digital Twin-Driven Intrusion Detection for Industrial SCADA: A Cyber-Physical Case Study
  preprints 2025 置信度 0.74
• Next-Generation Space Cardiology: Developing a COMSOL-Enabled Digital Heart Twin for Long-Duration Missions
  preprints 2025 置信度 0.74
• Metal Additive Manufacturing Defect Formation and Mitigation: Shrinkage Dynamics, Porosity Control, In-Situ Monitoring, and Post-Processing Strategies
  europepmc 2025 置信度 0.80
• A Systematic Review on the Current Research of Digital Twin in Power Equipment
  preprints 2025 置信度 0.74
• Digital Twinning Mechanism and Building Information Modeling for a Smart Parking Management System
  preprints 2025 置信度 0.74
• BLUE Building: A Next-Generation Paradigm for Spatial Intelligence
  preprints 2025 置信度 0.74
• Tunnel Rapid AI Classification (TRaiC): An Open-Source Code for 360° Tunnel Face Mapping, Discontinuity Analysis, and RAG-LLM Powered Geo-Engineering Reporting
  preprints 2025 置信度 0.74
• Mapping immersive digital tools in the ICT4Water Cluster: innovation, interoperability and impact.
  preprints 2025 置信度 0.74
• Process monitoring and quality prediction system of GMAW robot welding based on digital twin
  Abstract In the process of gas metal arc welding (GMAW), it is essential to ensure the quality of the weld seam. Traditional quality control methods suffer from latency and insufficient intelligence. To address these limitations, a process monitoring and quali…
  preprints Xianhua Tan, Ke Liu, Yongcheng Lin, Mingsong Chen 等 2025 置信度 0.74
• Case study report on design, manufacturing and digital twinning of a DED-arc steel node for construction
  europepmc 2025 置信度 0.80
• Navigating Sustainability in Pharma 5.0: The Role of Digital Twins in a Responsible Future
  Sustainability has become an essential priority across industries, as organizations grapple with the need to reduce environmental impact, conserve resources, and adapt to evolving regulations. In the pharmaceutical sector, the urgency of these demands is parti…
  europepmc Atif Ali, Syed Adnan Ali, Nawal Zaheer 2025 置信度 0.80 SustainabilityBusinessBiologyEcology
• Cybersecurity in Digital Twins and AI: An Intelligent Framework for Proactive Threat Detection and Response
  preprints 2025 置信度 0.74
• Raspberry Pi in Industry 4.0: A Comprehensive Review of Applications in Industrial IoT and Digital Twin Systems
  europepmc 2025 置信度 0.80
• Metal Additive Manufacturing Defect Formation and Mitigation: Shrinkage Dynamics, Porosity Control, In-Situ Monitoring, and Post-Processing Strategies
  europepmc 2025 置信度 0.80
• Physics-Informed Machine Learning for Intelligent Gas Turbine Digital Twins: A Review
  preprints 2025 置信度 0.74
• Smart Buildings meet the Metaverse: A Prototype for Predictive and Ecologically Intelligent Management
  preprints 2025 置信度 0.74
• Agentic AI: A Review, Applications, and Open Research Challenges
  preprints 2025 置信度 0.74
• Micellangelo: a Generative Model of Cell-Topography Interactions
  Understanding how materials influence cell behavior is central to biomaterial engineering, yet experimental approaches are limited by throughput and complexity. Here, we present Micellangelo, a generative AI model that simulates high-resolution fluorescence im…
  preprints 2025 置信度 0.74
• Securing the Future Smart Grid 3.0 through Leveraging the Models of Blockchain, Digital Twin, Edge Computing and Metaverse Synergies
  preprints 2025 置信度 0.74
• Mapping the healthy aging heart: a normative electrophysiological digital twin atlas for pathological remodeling assessment
  europepmc 2026 置信度 0.80
• Multi-parameter Intelligent Monitoring System for Traction Walking Plate Based on Digital Twin Technology
  preprints 2025 置信度 0.74
• AI-Augmented FEA for Offshore Wind Turbine Equipment: A State-of-the-Art Methodology for Accelerated Fabrication Review
  europepmc 2025 置信度 0.80
• A Technology Readiness Assessment Approach for Digital Twin Implementation in Smes
  Abstract Small and medium-sized enterprises (SMEs) face persistent challenges in adopting digital twin (DT) technologies due to limited resources and low digital maturity. In this research, the SME Smart Technology Readiness Assessment (SSTRA) method is adapte…
  preprints Stefano Larmelina, ALESSANDRO LUCAS DA SILVA, Lucas RIsso 2025 置信度 0.74
• Secure Cloud‑Streaming Digital Twin (SCSDT): A Cloud‑First Metaverse Architecture for Industrial Training
  Traditional extended reality (XR) training faces a fundamental trade-off: high-fidelity, in-situ VR solutions offer superior pedagogical outcomes but are limited by expensive, resource-intensive hardware, while web-based alternatives sacrifice immersion for sc…
  preprints Mihalache Ghinea, Gicu Călin Deac, Radu Ivanescu, Crina Narcisa Deac 等 2025 置信度 0.74 Cloud computingMetaverseComputer scienceArchitectureHuman–computer interaction
• Adaptive Control and Interoperability Frameworks for Wind Power Plant Integration: A Comprehensive Review of Strategies, Standards, and Real-Time Validation
  preprints 2025 置信度 0.74
• Enabling Intelligent Industrial Automation: A Review of Machine Learning Applications with Digital Twin and Edge AI Integration
  The integration of machine learning (ML) into industrial automation is fundamentally reshaping how manufacturing systems are monitored, inspected, and optimized. This review explores the transformative role of ML across three key domains: Predictive Maintenanc…
  europepmc Mohammad Abidur Rahman, Md Farhan Shahrior, Kamran Iqbal, Ali Abushaiba 2025 置信度 0.80
• MOSAIC: A scalable framework for fMRI dataset aggregation and modeling of human vision
  preprints 2025 置信度 0.74
• Systematic data-driven genome-scale metabolic model reduction for dynamic bioprocess modeling: CHO cell culture case study
  preprints 2025 置信度 0.74
• A Digital Twin Model for an Integrated In-Situ Production and Yard-Stock Optimization of Precast Concrete Components Leveraging BIM Technology
  Digital Twin (DT) technology has become a cornerstone of data-driven decision-making in the construction industry through its simulation and predictive capabilities. The integration of Building Information Modeling (BIM) and DT forms a closed-loop system that …
  preprints Junyoung Park, Jeeyoung Lim, Sunkuk Kim 2025 置信度 0.74
• Exploring innovative G-CSF schedules in AML cytarabine-based consolidation through a digital twin study of white blood cell recovery
  preprints 2025 置信度 0.74
• Smart Buildings Meet the Metaverse: A Prototype for Predictive and Ecologically Intelligent Management
  preprints 2025 置信度 0.74
• Multi-parameter Intelligent Monitoring System for Traction Walking Plate Based on Digital Twin Technology
  In order to solve the problem of safety accidents, such as the overturning of the traction walking plate and the jumping of subconductors, during the construction process of transmission line tension framing, because the construction personnel cannot fully mon…
  preprints 弛 张, Xiangbiao Leng, Xiaobin Li, longbin zhang 2025 置信度 0.74
• Microclimate Simulations Reveal the Potential of Multifunctional Green Infrastructure for Urban Heat Mitigation
  preprints 2025 置信度 0.74
• In search for the invisible: motor inhibition in monkey premotor cortex and its RNN replicas
  preprints 2025 置信度 0.74
• Enhancing Scientific Communication and Institutional Identity through a Retrieval-Augmented Generation Digital Personal Tutor
  preprints 2025 置信度 0.74
• The Psychology of Spiritual Relationships: Attachment, Fantasy Bonds, and Emotional Dependency in Twin Flame Beliefs
  preprints 2025 置信度 0.74
• Reconciling Urban Mobility and CCAM Digital Twins for Enhanced Integration and Mutual Advancement
  preprints 2025 置信度 0.74
• RETRACTED: Digital Twin-Assisted Vehicles Edge Network Computing Offloading Scheme
  Abstract The authors have requested that this preprint be removed from Research Square.
  preprints Zheng Yao, Qiwu Zhu, Pengjie Qin 2025 置信度 0.74
• Federated Learning for Power Cyber-Physical Systems: Toward Secure, Resilient, and Explainable Intelligence
  preprints 2025 置信度 0.74
• Industrial Scheduling in the Digital Era: Challenges, State-of-the-Art Methods, and Deep Learning Perspectives
  Industrial scheduling remains a pivotal discipline for efficiency, resilience, and competitiveness in manufacturing and service operations. The digital transformation, driven by paradigms such as Industry 4.0, has fundamentally reshaped the scheduling landscap…
  europepmc 2025 置信度 0.80
• Dynamic modeling and simulation of mass, momentum, and energy transport in a single-screw plastic extrusion process
  preprints 2025 置信度 0.74
• Investigation on digital twin of the ultraprecision machining system for manufacturing freeform surfaced components
  Abstract Digital Twin (DT) is widely regarded as the future for advanced engineering manufacture, addresses the critical challenge for continuous improvement and optimization of manufacturing systems through real-time machining process monitoring, in-process d…
  europepmc Qiao Xuetao, Wang Yibo, Ning Gou, Kai Cheng 等 2025 置信度 0.80
• Digital twin-based tool wear monitoring of micro-milling process
  preprints 2025 置信度 0.74
• Bioinspired NeuroPods: AI-Enhanced 4D Composite Bioprinting Revolutionizing Brain-on-Chip and Neural Regeneration
  Effective neural regeneration and realistic brain-on-a-chip platforms demand transformative methodologies capable of dynamically adapting their mechanical, electrical, and biochemical environments in synchrony with resident neural tissues. Recent innovations i…
  europepmc 2025 置信度 0.80
• MicroProphet: A Digital Twin Framework for Predicting Microbial Community Dynamics with Personalized Precision
  preprints 2025 置信度 0.74
• Efficient Calculation of Transformer Winding Vibration Field Based on Proper Orthogonal Decomposition Method
  preprints 2025 置信度 0.74
• Adaptive Particle Swarm Optimization for Non-Invasive Parasitic Parameter Estimation in DC-DC Boost Converters
  preprints 2025 置信度 0.74
• Autonomous BIM-Aware UAV Path Planning for Construction Inspection
  preprints 2025 置信度 0.74
• Agentic Generative AI and National Security: Policy Recommendations for US Military Competitiveness
  This paper presents a comprehensive analysis of Agentic Gen Artificial Intelligence (AI) frameworks and their integration into modern military systems. We examine the architectural foundations, development pipelines, and security considerations for deploying a…
  preprints 2025 置信度 0.74
• Physics-Informed Digital Twin Can Predict Cerebral Blood Flow and Cerebral Vascular Regulation Mechanisms in Neurocritical Care Patients
  preprints 2025 置信度 0.74
• Bridging the Heterogeneity of Myasthenia Gravis Severity Scores for Digital Twin Development
  preprints 2025 置信度 0.74
• Adaptive Particle Swarm Optimization for Non-Invasive Parasitic Parameter Estimation in DC-DC Boost Converters
  preprints 2025 置信度 0.74
• TwinVax: Leveraging Digital Twin Simulation to Monitor Vaccine Storage and Population Immunisation
  Abstract Background This paper presents the application of simulation to assess the functionality of a proposed Digital Twin (DT) architecture for immunisation services in primary healthcare centres. The solution is based on Industry 4.0 concepts and technolog…
  preprints Leonardo Oliveira El-Warrak, Claudio Miceli de Farias, Victor Hugo Dias Macedo Azevedo Costa 2025 置信度 0.74
• Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data
  preprints 2025 置信度 0.74
• Data-Driven SHM of a Timber Lamella Dome Using CISMN
  preprints 2025 置信度 0.74
• Digital twin integrating clinical, morphology and hemodynamic data to identify stroke risk factors
  preprints 2025 置信度 0.74
• Securing Digital Twins: MLEVES - A Novel Framework for Multi-Layer Encryption and Adaptive Threat Detection
  europepmc 2025 置信度 0.80
• A Review: Research Trend of Digitalization Centered Approach in Risk Management of Logistics Loss from FPSO to Tanker
  preprints 2025 置信度 0.74
• PIML-based Real-time Long-horizon temperature Fields prediction in metallic additive manufacturing
  europepmc 2025 置信度 0.80
• Digital Twin of Nonpregnant Human Uterus
  preprints 2025 置信度 0.74
• Hybrid Comparative Modeling of ANN and SVM for Accurate Machining Performance Prediction of AlSiC MMC
  preprints 2025 置信度 0.74
• Towards Sustainable Buildings and Energy Communities: AI-Driven Transactive Energy, Smart Local Microgrids, and Life Cycle Integration
  preprints 2025 置信度 0.74