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• NMR-based Urinary Biomarkers in Pediatric Primary Mitochondrial Disorders and Chronic Kidney Disease: Shared Mitochondrial Dysfunction, Diverging Biosignatures
  europepmc 2025 置信度 0.80
• Co-enrichment of Ce and organics in microbe-like structures at the deep-sea ferromanganese crust surface.
  europepmc 2026 置信度 0.80
• Documenting the Occurrence of Microbial Carbonate Deposits in Puerto Rico
  europepmc 2026 置信度 0.80
• Spectroscopic Protocol for Biosignature Detection: Arctic Ice Samples as Analogs for Icy Moons.
  The moons of Jupiter and Saturn, such as Europa and Enceladus, are strong candidates for the search for life outside of Earth. Together with the use of direct observational methods, physical and chemical processes that take place on icy moons may be studied on…
  pubmed Calapez F, Dias R, Cesário R, Pedras B 等 2025 置信度 0.82
• Biotic and Abiotic Signatures in Sulfate- and Carbonate-Rich Hypersaline Lakes as Analogs for Mars.
  Lacustrine sulfate- and carbonate-rich deposits have been detected at Jezero and Gale craters on Mars. The preservation of potential biosignatures in these sites may depend on the nature of precipitated salts and the early diagenetic history of in situ mineral…
  europepmc Hemani Kalucha, Benjamin W. Johnson, Miquela Ingalls, Paul D. Asimow 等 2026 置信度 0.80
• Platelet Activation and a Platelet Biosignature Are Associated With Cardiovascular Risk in Patients With Controlled Psoriasis.
  BACKGROUND: The underlying mechanisms of atherosclerosis and strategies for identifying high cardiovascular risk in psoriasis are incompletely understood. Platelet activity is increased in psoriasis and induces vascular dysfunction. We investigated the platele…
  europepmc Michael S. Garshick, Kamelia Drenkova, Filipp Kazatsker, Isabelle Boothman 等 2025 置信度 0.80
• An organics-forward approach to searching for life on Mars.
  europepmc 2026 置信度 0.80
• Asgard Archaea as Living Fossils: Illuminating the Origins of Eukaryotic Complexity
  europepmc 2025 置信度 0.80
• Plasma proteomics for biomarker discovery in childhood tuberculosis.
  europepmc 2025 置信度 0.80
• Exoplanet Biosignatures: A Review of Remotely Detectable Signs of Life
  In the coming years and decades, advanced space- and ground-based observatories will allow an unprecedented opportunity to probe the atmospheres and surfaces of potentially habitable exoplanets for signatures of life. Life on Earth, through its gaseous product…
  europepmc Edward W. Schwieterman, Nancy Y. Kiang, Mary N. Parenteau, Chester E. Harman 等 2018 置信度 0.80 ExoplanetAstrobiologyContext (archaeology)Extraterrestrial lifeSolar System
• Exoplanet Biosignatures: Understanding Oxygen as a Biosignature in the Context of Its Environment
  We describe how environmental context can help determine whether oxygen (O2) detected in extrasolar planetary observations is more likely to have a biological source. Here we provide an in-depth, interdisciplinary example of O2 biosignature identification and …
  europepmc Victoria Meadows, Christopher T. Reinhard, Giada Arney, Mary N. Parenteau 等 2018 置信度 0.80 ExoplanetAstrobiologyContext (archaeology)HabitabilityPlanetary surface
• Habitability on Early Mars and the Search for Biosignatures with the ExoMars Rover
  The second ExoMars mission will be launched in 2020 to target an ancient location interpreted to have strong potential for past habitability and for preserving physical and chemical biosignatures (as well as abiotic/prebiotic organics). The mission will delive…
  openalex Jorge L. Vago, Francès Westall, Landing S Pasteur Instrument Teams, A. J. Coates 等 2017-07-01 置信度 0.72 HabitabilityAstrobiologyExtraterrestrial lifeMars Exploration ProgramContext (archaeology)
• Iron Isotope Biosignatures
  The (56)Fe/(54)Fe of Fe-bearing phases precipitated in sedimentary environments varies by 2.5 per mil (delta(56)Fe values of +0.9 to -1. 6 per mil). In contrast, the (56)Fe/(54)Fe of Fe-bearing phases in igneous rocks from Earth and the moon does not vary meas…
  openalex Brian L. Beard, Clark M. Johnson, Lea Cox, Henry Sun 等 1999-09-17 置信度 0.72 FerrihydriteFractionationSedimentary rockGeochemistryFerrous
• Remote Sensing of Planetary Properties and Biosignatures on Extrasolar Terrestrial Planets
  The major goals of NASA's Terrestrial Planet Finder (TPF) and the European Space Agency's Darwin missions are to detect terrestrial-sized extrasolar planets directly and to seek spectroscopic evidence of habitable conditions and life. Here we recommend wavelen…
  openalex David J. Des Marais, Martin Harwit, K. W. Jucks, James F. Kasting 等 2002-06-01 置信度 0.72 AstrobiologyExoplanetTerrestrial planetHabitabilitySolar System
• Biosignatures from Earth-Like Planets Around M Dwarfs
  Coupled one-dimensional photochemical-climate calculations have been performed for hypothetical Earth-like planets around M dwarfs. Visible/near-infrared and thermal-infrared synthetic spectra of these planets were generated to determine which biosignature gas…
  openalex Antígona Segura, James F. Kasting, Victoria Meadows, Martin Cohen 等 2005-12-01 置信度 0.72 PlanetExoplanetPhysicsStarsAstrobiology
• Toward a Biosignature for Suicide
  OBJECTIVE: Suicide, a major cause of death worldwide, has distinct biological underpinnings. The authors review and synthesize the research literature on biomarkers of suicide, with the aim of using the findings of these studies to develop a coherent model for…
  pubmed María A. Oquendo, Gregory M. Sullivan, Katherin Sudol, Enrique Baca‐García 等 2014 Dec 1 置信度 0.82 SerotonergicNeuroscienceContext (archaeology)DiathesisPsychology
• Morphological Biosignatures and the Search for Life on Mars
  This report provides a rationale for the advances in instrumentation and understanding needed to assess claims of ancient and extraterrestrial life made on the basis of morphological biosignatures. Morphological biosignatures consist of bona fide microbial fos…
  openalex Sherry L. Cady, Jack D. Farmer, J. P. Grotzinger, J. William Schopf 等 2003-06-01 置信度 0.72 AstrobiologyExtraterrestrial lifeLife on MarsMars Exploration ProgramGeologic record
• Biosignature Preservation and Detection in Mars Analog Environments
  This review of material relevant to the Conference on Biosignature Preservation and Detection in Mars Analog Environments summarizes the meeting materials and discussions and is further expanded upon by detailed references to the published literature. From thi…
  pubmed L. E. Hays, Heather V. Graham, David J. Des Marais, Elisabeth M. Hausrath 等 2017 Apr 置信度 0.82 AstrobiologyMars Exploration ProgramHabitabilityExploration of MarsContext (archaeology)
• Exoplanet Biosignatures: A Framework for Their Assessment
  Finding life on exoplanets from telescopic observations is an ultimate goal of exoplanet science. Life produces gases and other substances, such as pigments, which can have distinct spectral or photometric signatures. Whether or not life is found with future d…
  europepmc David C. Catling, Joshua Krissansen-Totton, Nancy Y. Kiang, David Crisp 等 2018 置信度 0.80 ExoplanetContext (archaeology)Bayesian probabilityAstrobiologyHabitability
• Vegetation's Red Edge: A Possible Spectroscopic Biosignature of Extraterrestrial Plants
  Earth's deciduous plants have a sharp order-of-magnitude increase in leaf reflectance between approximately 700 and 750 nm wavelength. This strong reflectance of Earth's vegetation suggests that surface biosignatures with sharp spectral features might be detec…
  pubmed S. Seager, Edwin L. Turner, J. Schafer, Eric B. Ford 等 2005 Jun 置信度 0.82 Red edgeAstrobiologyVegetation (pathology)PlanetExoplanet
• M Stars as Targets for Terrestrial Exoplanet Searches And Biosignature Detection
  The changing view of planets orbiting low mass stars, M stars, as potentially hospitable worlds for life and its remote detection was motivated by several factors, including the demonstration of viable atmospheres and oceans on tidally locked planets, normal i…
  pubmed John Scalo, Lisa Kaltenegger, Antígona Segura, M. Fridlund 等 2007 Feb 置信度 0.82 ExoplanetPlanetTerrestrial planetAstrobiologyPhysics
• Cave Biosignature Suites: Microbes, Minerals, and Mars
  Earth's subsurface offers one of the best possible sites to search for microbial life and the characteristic lithologies that life leaves behind. The subterrain may be equally valuable for astrobiology. Where surface conditions are particularly hostile, like o…
  openalex Penelope J. Boston, M. Spilde, Diana E. Northup, Leslie A. Melim 等 2001-03-01 置信度 0.72 AstrobiologyLife on MarsMars Exploration ProgramCaveExploration of Mars
• Preservation of Martian Organic and Environmental Records: Final Report of the Mars Biosignature Working Group
  The Mars Science Laboratory (MSL) has an instrument package capable of making measurements of past and present environmental conditions. The data generated may tell us if Mars is, or ever was, able to support life. However, the knowledge of Mars' past history …
  pubmed Roger E. Summons, Jan P. Amend, D. L. Bish, Roger Buick 等 2011 Mar 置信度 0.82 Mars Exploration ProgramMartianAstrobiologyGeologic recordExtraterrestrial life
• The Search for Chiral Asymmetry as a Potential Biosignature in our Solar System
  Abstract The search for evidence of extraterrestrial life in our Solar System is currently guided by our understanding of terrestrial biology and its associated biosignatures. The observed homochirality in all life on Earth, that is, the predominance of ?left-…
  openalex D. P. Glavin, Aaron S. Burton, Jamie E. Elsila, José C. Aponte 等 2019-11-19 置信度 0.72 HomochiralityAbiogenesisMeteoriteExtraterrestrial lifeAstrobiology
• Molecular Biosignatures
  openalex Roger E. Summons, Pierre Albrecht, Gene D. McDonald, J. Michael Moldowan 2007-10-09 置信度 0.72 AstrobiologyTerminologyLiving systemsAbiogenesisOrganism
• Iron stable isotopes: beyond biosignatures
  openalex Ariel D. Anbar 2003-12-04 置信度 0.72 AstrobiologyBiogeochemistryGeologyEarth scienceIsotope geochemistry
• Lithotrophic iron-oxidizing bacteria produce organic stalks to control mineral growth: implications for biosignature formation
  Abstract Neutrophilic Fe-oxidizing bacteria (FeOB) are often identified by their distinctive morphologies, such as the extracellular twisted ribbon-like stalks formed by Gallionella ferruginea or Mariprofundus ferrooxydans. Similar filaments preserved in silic…
  openalex Clara S. Chan, Sirine C. Fakra, David Emerson, Emily J. Fleming 等 2010-11-25 置信度 0.72 Transmission electron microscopyOxidizing agentBiomineralizationStalkExtracellular polymeric substance
• Biosignatures on Mars: What, Where, and How? Implications for the Search for Martian Life
  UNLABELLED: The search for traces of life is one of the principal objectives of Mars exploration. Central to this objective is the concept of habitability, the set of conditions that allows the appearance of life and successful establishment of microorganisms …
  openalex Francès Westall, Frédéric Foucher, N. Bost, Marylène Bertrand 等 2015-11-01 置信度 0.72 AstrobiologyMartianMars Exploration ProgramLife on MarsHabitability
• Establishing moderators and biosignatures of antidepressant response in clinical care (EMBARC): Rationale and design
  openalex Madhukar H. Trivedi, Patrick J. McGrath, Maurizio Fava, Ramin V. Parsey 等 2016-03-15 置信度 0.72 AntidepressantPsychologyPsychotherapistPsychiatryClinical psychology
• Exoplanet Biosignatures: Observational Prospects
  Exoplanet hunting efforts have revealed the prevalence of exotic worlds with diverse properties, including Earth-sized bodies, which has fueled our endeavor to search for life beyond the Solar System. Accumulating experiences in astrophysical, chemical, and cl…
  europepmc Yuka Fujii, Daniel Angerhausen, Russell Deitrick, Shawn Domagal-Goldman 等 2018 置信度 0.80 ExoplanetAstrobiologyPlanetPlanetary habitabilityHabitability
• Habitability and Biosignatures of Hycean Worlds
  Abstract We investigate a new class of habitable planets composed of water-rich interiors with massive oceans underlying H 2 -rich atmospheres, referred to here as Hycean worlds. With densities between those of rocky super-Earths and more extended mini-Neptune…
  openalex Nikku Madhusudhan, Anjali A. A. Piette, Savvas Constantinou 2021-08-26 置信度 0.72 HabitabilityExoplanetAstrobiologyPlanetPhysics
• Mineralogical Biosignatures and the Search for Life on Mars
  If life ever existed, or still exists, on Mars, its record is likely to be found in minerals formed by, or in association with, microorganisms. An important concept regarding interpretation of the mineralogical record for evidence of life is that, broadly defi…
  pubmed Jillian F. Banfield, John W. Moreau, Clara S. Chan, Susan A. Welch 等 2001 Winter 置信度 0.82 AstrobiologyMars Exploration ProgramLife on MarsHabitabilityGeology
• Biosignatures as revealed by spectropolarimetry of Earthshine
  openalex M. Sterzik, S. Bagnulo, Ε. Πάλλη 2012-02-28 置信度 0.72 ExoplanetPlanetAtmosphere (unit)Spectral lineAstrobiology
• Identifying molecules as biosignatures with assembly theory and mass spectrometry
  The search for alien life is hard because we do not know what signatures are unique to life. We show why complex molecules found in high abundance are universal biosignatures and demonstrate the first intrinsic experimentally tractable measure of molecular com…
  openalex Stuart M. Marshall, Cole Mathis, Emma Carrick, Graham Keenan 等 2021-05-24 置信度 0.72 Extraterrestrial lifeAbiogenesisAstrobiologyMeasure (data warehouse)Set (abstract data type)
• Biosignatures of Early Earths
  A major goal of NASA's Origins Program is to find habitable planets around other stars and determine which might harbor life. Determining whether or not an extrasolar planet harbors life requires an understanding of what spectral features (i.e., biosignatures)…
  openalex C. B. Pilcher, Carl B. Pilcher 2003-09-01 置信度 0.72 AstrobiologyOrganosulfur compoundsBiosphereExoplanetPlanet
• Exoplanet Biosignatures: Future Directions
  We introduce a Bayesian method for guiding future directions for detection of life on exoplanets. We describe empirical and theoretical work necessary to place constraints on the relevant likelihoods, including those emerging from better understanding stellar …
  europepmc Sara Imari Walker, William Bains, Leroy Cronin, Shiladitya DasSarma 等 2018 置信度 0.80 ExoplanetHabitabilityComputer scienceAstrobiologyArtificial life
• Association of RNA Biosignatures With Bacterial Infections in Febrile Infants Aged 60 Days or Younger
  IMPORTANCE: Young febrile infants are at substantial risk of serious bacterial infections; however, the current culture-based diagnosis has limitations. Analysis of host expression patterns ("RNA biosignatures") in response to infections may provide an alterna…
  openalex Prashant Mahajan, Nathan Kuppermann, Asunción Mejías, Nicolás M. Suárez 等 2016-08-23 置信度 0.72 MedicineBacteremiaObservational studyMicrobiological cultureProspective cohort study
• Deciphering Biosignatures in Planetary Contexts
  Microbial life permeates Earth's critical zone and has likely inhabited nearly all our planet's surface and near subsurface since before the beginning of the sedimentary rock record. Given the vast time that Earth has been teeming with life, do astrobiologists…
  europepmc Marjorie A. Chan, Nancy W. Hinman, Sally L. Potter‐McIntyre, Keith E. Schubert 等 2019 置信度 0.80 AstrobiologyExtraterrestrial lifeContext (archaeology)Geologic recordEarth science
• Phosphine as a Biosignature Gas in Exoplanet Atmospheres
  A long-term goal of exoplanet studies is the identification and detection of biosignature gases. Beyond the most discussed biosignature gas O2, only a handful of gases have been considered in detail. In this study, we evaluate phosphine (PH3). On Earth, PH3 is…
  openalex Clara Sousa-Silva, Sara Seager, Sukrit Ranjan, Janusz Jurand Petkowski 等 2019-11-22 置信度 0.72 OutgassingExoplanetAstrobiologyAtmosphere (unit)Planet
• Silica deposits on Mars with features resembling hot spring biosignatures at El Tatio in Chile
  O) in an ancient volcanic hydrothermal setting in Gusev crater. An origin via either fumarole-related acid-sulfate leaching or precipitation from hot spring fluids was suggested previously. However, the potential significance of the characteristic nodular and …
  openalex Steven W. Ruff, Jack D. Farmer 2016-11-17 置信度 0.72 Mars Exploration ProgramHot springImpact craterGeologyFumarole
• Using Biogenic Sulfur Gases as Remotely Detectable Biosignatures on Anoxic Planets
  We used one-dimensional photochemical and radiative transfer models to study the potential of organic sulfur compounds (CS(2), OCS, CH(3)SH, CH(3)SCH(3), and CH(3)S(2)CH(3)) to act as remotely detectable biosignatures in anoxic exoplanetary atmospheres. Concen…
  openalex Shawn Domagal‐Goldman, Victoria Meadows, Mark W. Claire, James F. Kasting 2011-06-01 置信度 0.72 SulfurDimethyl sulfideMethaneAnoxic watersDimethyl disulfide
• Preservation of potential biosignatures in the shallow subsurface of Europa
  openalex Tom Nordheim, K. P. Hand, C. Paranicas 2018-07-19 置信度 0.72 AstrobiologyMagnetosphereJupiter (rocket family)CrustGeology
• Toward a List of Molecules as Potential Biosignature Gases for the Search for Life on Exoplanets and Applications to Terrestrial Biochemistry
  UNLABELLED: Thousands of exoplanets are known to orbit nearby stars. Plans for the next generation of space-based and ground-based telescopes are fueling the anticipation that a precious few habitable planets can be identified in the coming decade. Even more h…
  openalex S. Seager, W. Bains, Janusz J. Petkowski, J.J. Petkowski 2016-04-20 置信度 0.72 ExoplanetAstrobiologyHabitabilityEnvironmental scienceChemistry
• An Astrophysical View of Earth-Based Metabolic Biosignature Gases
  Microbial life on Earth uses a wide range of chemical and energetic resources from diverse habitats. An outcome of this microbial diversity is an extensive and varied list of metabolic byproducts. We review key points of Earth-based microbial metabolism that a…
  pubmed Sara Seager, Matthew O. Schrenk, William Bains, Matthew Schrenk 等 2012 Jan 置信度 0.82 ExoplanetAstrobiologyEarly EarthEarth (classical element)Primary (astronomy)
• A review of exoplanetary biosignatures
  We review the field of exoplanetary biosignatures with a main focus upon atmospheric gas-phase species. Due to the paucity of data in Earth-like planetary atmospheres a common approach is to extrapolate knowledge from the Solar System and Early Earth to Earth-…
  openalex John Lee Grenfell 2017-10-13 置信度 0.72 ExoplanetAstrobiologyContext (archaeology)PhysicsSolar System
• BIOSIGNATURE GASES IN H₂-DOMINATED ATMOSPHERES ON ROCKY EXOPLANETS
  Super-Earth exoplanets are being discovered with increasing frequency and some will be able to retain stable H 2 -dominated atmospheres. We study biosignature gases on exoplanets with thin H 2 atmospheres and habitable surface temperatures, using a model atmos…
  openalex S. Seager, W. Bains, Renyu Hu, R. Hu 2013-10-18 置信度 0.72 ExoplanetAstrobiologyAtmosphere (unit)PhotodissociationCircumstellar habitable zone
• Truncated hexa-octahedral magnetite crystals in ALH84001: Presumptive biosignatures
  McKay et al. [(1996) Science 273, 924-930] suggested that carbonate globules in the meteorite ALH84001 contained the fossil remains of Martian microbes. We have characterized a subpopulation of magnetite (Fe(3)O(4)) crystals present in abundance within the Fe-…
  openalex K. L. Thomas-Keprta, S. J. Clemett, Dennis A. Bazylinski, Joseph L. Kirschvink 等 2001-02-27 置信度 0.72 MeteoriteMagnetotactic bacteriaMagnetiteMartianAstrobiology
• A BIOMASS-BASED MODEL TO ESTIMATE THE PLAUSIBILITY OF EXOPLANET BIOSIGNATURE GASES
  Biosignature gas detection is one of the ultimate future goals for exoplanet atmosphere studies. We have created a framework for linking biosignature gas detectability to biomass estimates, including atmospheric photochemistry and biological thermodynamics. Th…
  openalex Sara Seager, William Bains, Renyu Hu, S. Seager 等 2013-09-12 置信度 0.72 ExoplanetAstrobiologyBiomass (ecology)Atmosphere (unit)Outgassing
• Detectability of Biosignatures in Anoxic Atmospheres with the James Webb Space Telescope: A TRAPPIST-1e Case Study
  Abstract The James Webb Space Telescope ( JWST ) may be capable of finding biogenic gases in the atmospheres of habitable exoplanets around low-mass stars. Considerable attention has been given to the detectability of biogenic oxygen, which could be found usin…
  openalex Joshua Krissansen‐Totton, Ryan Garland, P. G. J. Irwin, David C. Catling 2018-08-22 置信度 0.72 James Webb Space TelescopeAstrobiologyExoplanetEarly EarthMethane
• Nonphotosynthetic Pigments as Potential Biosignatures
  Previous work on possible surface reflectance biosignatures for Earth-like planets has typically focused on analogues to spectral features produced by photosynthetic organisms on Earth, such as the vegetation red edge. Although oxygenic photosynthesis, facilit…
  openalex Edward W. Schwieterman, Charles S. Cockell, Victoria Meadows 2015-05-01 置信度 0.72 PlanetAstrobiologyAtmosphere (unit)Environmental sciencePhotosynthesis
• Biosignatures in Rocks
  openalex Francès Westall, Barbara Cavalazzi 2011-01-01 置信度 0.72 GeologyGeochemistryAstrobiologyPhysics
• The case and context for atmospheric methane as an exoplanet biosignature
  Methane has been proposed as an exoplanet biosignature. Imminent observations with the James Webb Space Telescope may enable methane detections on potentially habitable exoplanets, so it is essential to assess in what planetary contexts methane is a compelling…
  pubmed Maggie Thompson, Joshua Krissansen‐Totton, Nicholas F. Wogan, M. Telus 等 2022 Apr 5 置信度 0.82 ExoplanetAstrobiologyMethaneContext (archaeology)Atmospheric methane
• Graphitic Carbons and Biosignatures
  The unambiguous identification of graphitic carbons as remains of life in ancient rocks is challenging because fossilized biogenic molecules are inevitably altered and degraded during diagenesis and metamorphism of the host rocks. Yet, recent studies have high…
  openalex Sylvain Bernard, Dominic Papineau 2014-12-01 置信度 0.72 CitationIconArt historyArtSociology
• A probabilistic framework for identifying biosignatures using Pathway Complexity
  One thing that discriminates living things from inanimate matter is their ability to generate similarly complex or non-random structures in a large abundance. From DNA sequences to folded protein structures, living cells, microbial communities and multicellula…
  openalex Stuart M. Marshall, Alastair R. G. Murray, Leroy Cronin 2017-11-13 置信度 0.72 Multicellular organismLiving systemsOrganismComputer scienceProbabilistic logic
• Disequilibrium biosignatures over Earth history and implications for detecting exoplanet life
  are likely biogenic due to the difficulty in maintaining large abiotic methane fluxes to support high methane levels in anoxic atmospheres. Biogenicity would be strengthened by the absence of abundant CO, which should not coexist in a biological scenario.
  openalex Joshua Krissansen-Totton, Stephanie Olson, David C. Catling 2018-01-05 置信度 0.72 DisequilibriumAstrobiologyArcheanProterozoicExoplanet
• Morphological Biosignatures in Early Terrestrial and Extraterrestrial Materials
  openalex Francès Westall 2008-03-01 置信度 0.72 AstrobiologyExtraterrestrial lifePlanetary scienceSolar SystemEnvironmental science
• Development of a Metabolic Biosignature for Detection of Early Lyme Disease
  BACKGROUND: Early Lyme disease patients often present to the clinic prior to developing a detectable antibody response to Borrelia burgdorferi, the etiologic agent. Thus, existing 2-tier serology-based assays yield low sensitivities (29%-40%) for early infecti…
  openalex Claudia R. Molins, Laura V. Ashton, Gary P. Wormser, Ann M. Hess 等 2015-03-11 置信度 0.72 Lyme diseaseMedicineBorrelia burgdorferiSerologyDisease
• Biosignatures for Astrobiology
  openalex Cavalazzi, Barbara, Francès Westall 2018-10-01 置信度 0.72 AstrobiologyExtraterrestrial lifeExtant taxonPhysicsBiology
• Sensor Web for in situ exploration of gaseous biosignatures
  A Sensor Web is a system of intra-communicating spatially distributed sensor pods that can be deployed to monitor and explore new environments. By its very nature, the Sensor Web provides spatio-temporal data in a form consistent with that needed for environme…
  openalex K. A. Delin, Shannon P. Jackson 2002-11-08 置信度 0.72 In situAstrobiologyComputer scienceEnvironmental scienceRemote sensing
• False biosignatures on Mars: anticipating ambiguity
  It is often acknowledged that the search for life on Mars might produce false positive results, particularly via the detection of objects, patterns or substances that resemble the products of life in some way but are not biogenic. The success of major current …
  openalex Sean McMahon, Julie Cosmidis 2021-11-17 置信度 0.72 AstrobiologyMars Exploration ProgramLife on MarsSolar SystemExtraterrestrial life
• Exoplanet Biosignatures: At the Dawn of a New Era of Planetary Observations
  The rapid rate of discoveries of exoplanets has expanded the scope of the science possible for the remote detection of life beyond Earth. The Exoplanet Biosignatures Workshop Without Walls (EBWWW) held in 2016 engaged the international scientific community acr…
  europepmc Nancy Y. Kiang, Shawn Domagal‐Goldman, Mary N. Parenteau, David C. Catling 等 2018 置信度 0.80 ExoplanetContext (archaeology)Scope (computer science)AstrobiologyExtraterrestrial life
• Fingerprinting Non-Terran Biosignatures
  Most strategies for life detection rely upon finding features known to be associated with terran life, such as particular classes of molecules. But life may be vastly different on other planets and moons, particularly as we expand our efforts to explore ocean …
  openalex S. S. Johnson, Eric V. Anslyn, Heather V. Graham, P. R. Mahaffy 等 2018-03-29 置信度 0.72 AstrobiologyBiology
• Magnetofossils from Ancient Mars: a Robust Biosignature in the Martian Meteorite ALH84001
  Evidence of biogenic activity on Mars has profound scientific implications for our understanding of the origin of life on Earth and the presence and diversity of life within the Cosmos. Analysis of the Martian meteorite Allan Hills 84001 (ALH84001) revealed se…
  pubmed K. L. Thomas-Keprta, S. J. Clemett, Dennis A. Bazylinski, Joseph L. Kirschvink 等 2002 Aug 置信度 0.82 MeteoriteMartianAstrobiologyMagnetotactic bacteriaMars Exploration Program
• Some perspectives on isotope biosignatures for early life
  openalex Juske Horita 2005-04-11 置信度 0.72 Abiogenic petroleum originAstrobiologyAbiogenesisEarth scienceIsotopes of carbon
• Atmospheric Seasonality as an Exoplanet Biosignature
  Abstract Current investigations of exoplanet biosignatures have focused on static evidence of life, such as the presence of biogenic gases like O 2 or CH 4 . However, the expected diversity of terrestrial planet atmospheres and the likelihood of both “false po…
  openalex Stephanie L. Olson, Edward W. Schwieterman, Christopher T. Reinhard, Andy Ridgwell 等 2018-05-09 置信度 0.72 ExoplanetAstrobiologySeasonalityPlanetBiosphere
• Stromatolites: biogenicity, biosignatures, and bioconfusion
  Stromatolites represent a multifarious system of nested, physically, chemically, and biologically influenced components that range in scale from microscopic to macroscopic. These components can include microorganisms, organic compounds of microorganisms, sedim…
  openalex Stanley M. Awramik, Kathleen Grey 2005-08-18 置信度 0.72 StromatolitePaleontologyProterozoicGeologyArchean
• Martian sub-surface ionising radiation: biosignatures and geology
  Abstract. The surface of Mars, unshielded by thick atmosphere or global magnetic field, is exposed to high levels of cosmic radiation. This ionising radiation field is deleterious to the survival of dormant cells or spores and the persistence of molecular biom…
  openalex Lewis Dartnell, L. Desorgher, John M. Ward, A. J. Coates 2007-07-30 置信度 0.72 MartianMars Exploration ProgramMartian surfaceRegolithPermafrost
• Organic Haze as a Biosignature in Anoxic Earth-like Atmospheres
  Early Earth may have hosted a biologically mediated global organic haze during the Archean eon (3.8–2.5 billion years ago). This haze would have significantly impacted multiple aspects of our planet, including its potential for habitability and its spectral ap…
  openalex Giada Arney, Shawn Domagal‐Goldman, Victoria Meadows, Shawn D. Domagal-Goldman 等 2017-11-30 置信度 0.72 HazeAstrobiologyEarly EarthMethaneExoplanet
• A metabolic biosignature of early response to anti-tuberculosis treatment
  Abstract Background The successful treatment of tuberculosis (TB) requires long-term multidrug chemotherapy. Clinical trials to evaluate new drugs and regimens for TB treatment are protracted due to the slow clearance of Mycobacterium tuberculosis (Mtb) infect…
  openalex Sebabrata Mahapatra, Ann M. Hess, John L. Johnson, Kathleen D. Eisenach 等 2014-01-31 置信度 0.72 TuberculosisMedicineMycobacterium tuberculosisInternal medicineLogistic regression
• Tracing Biosignature Preservation of Geothermally Silicified Microbial Textures into the Geological Record
  New Zealand and Argentine (Late Jurassic–Recent) siliceous hot-spring deposits (sinter) reveal preservation pathways of environmentally controlled, microbe-dominated sedimentary facies over geological time scales. Texturally distinctive, laminated to thinly la…
  openalex Kathleen A. Campbell, Bridget Y. Lynne, Kim M. Handley, Sacha Jordan 等 2015-10-01 置信度 0.72 GeologyMicrobial matHot springGeologic recordStromatolite
• Using Dimers to Measure Biosignatures and Atmospheric Pressure for Terrestrial Exoplanets
  We present a new method to probe atmospheric pressure on Earth-like planets using (O2-O2) dimers in the near-infrared. We also show that dimer features could be the most readily detectable biosignatures for Earth-like atmospheres and may even be detectable in …
  openalex Amit Misra, Victoria Meadows, Mark Claire, Dave Crisp 2014-01-16 置信度 0.72 ExoplanetPlanetJames Webb Space TelescopeAstrobiologyTransit (satellite)
• The Coevolution of Life and Environment on Mars: An Ecosystem Perspective on the Robotic Exploration of Biosignatures
  Earth's biological and environmental evolution are intertwined and inseparable. This coevolution has become a fundamental concept in astrobiology and is key to the search for life beyond our planet. In the case of Mars, whether a coevolution took place is unkn…
  openalex Nathalie A. Cabrol 2017-12-18 置信度 0.72 AstrobiologyMars Exploration ProgramCoevolutionHabitabilityContext (archaeology)
• Potential Biosignatures in Super-Earth Atmospheres I. Spectral appearance of super-Earths around M dwarfs
  Atmospheric temperature and mixing ratio profiles of terrestrial planets vary with the spectral energy flux distribution for different types of M-dwarf stars and the planetary gravity. We investigate the resulting effects on the spectral appearance of molecula…
  openalex H. Rauer, S Gebauer, Philip von Paris, J. Cabrera 等 2011-01-01 置信度 0.72 PlanetPhysicsEclipseAtmosphere (unit)Exoplanet
• Searching for biosignatures in sedimentary rocks from early Earth and Mars
  With the landing of the Perseverance rover and the search for biosignatures on Mars, it is important to understand how these signs of life can be preserved and interpreted. This Review describes these signatures on Earth and how terrestrial analogues can infor…
  openalex Tanja Bosak, Kelsey Moore, Jian Gong, J. P. Grotzinger 2021-06-01 置信度 0.72 AstrobiologyMars Exploration ProgramMartianGeologyLife on Mars
• Toward a Unified Biosignature for Tuberculosis
  Accurate and rapid diagnosis of active tuberculosis (TB) disease is still hampered by inadequate tools. Although current assays relying on single-marker readouts mostly display inadequate sensitivity and/or specificity, host-related multimarker signatures are …
  pubmed Jeroen Maertzdorf, Stefan H. E. Kaufmann, January Weiner, J. Maertzdorf 等 2014 Oct 23 置信度 0.82 TuberculosisIdentification (biology)DiseaseComputer scienceHost (biology)
• Degradation of Cyanobacterial Biosignatures by Ionizing Radiation
  Primitive photosynthetic microorganisms, either dormant or dead, may remain today on the martian surface, akin to terrestrial cyanobacteria surviving endolithically in martian analog sites on Earth such as the Antarctic Dry Valleys and the Atacama Desert. Pote…
  openalex Lewis Dartnell, Michael C. Storrie‐Lombardi, Conrad W. Mullineaux, Alexander V. Ruban 等 2011-12-01 置信度 0.72 AstrobiologyMartianMartian surfaceIonizing radiationMars Exploration Program
• A diagnostic host response biosignature for COVID-19 from RNA profiling of nasal swabs and blood
  Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease-19 (COVID-19), has emerged as the cause of a global pandemic. We used RNA sequencing to analyze 286 nasopharyngeal (NP) swab and 53 whole-blood (WB) samples from 333…
  openalex Dianna Ng, Andrea Granados, Yale Santos, Venice Servellita 等 2021-02-03 置信度 0.72 Coronavirus disease 2019 (COVID-19)Host responseHost (biology)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Virology
• Is There Such a Thing as a Biosignature?
  The concept of a biosignature is widely used in astrobiology to suggest a link between some observation and a biological cause, given some context. The term itself has been defined and used in several ways in different parts of the scientific community involve…
  pubmed Christophe Malaterre, I. L. ten Kate, Mickaël Baqué, Vinciane Debaille 等 2023 置信度 0.82 CLARITYContext (archaeology)WorryHabitabilityComputer science
• Enhanced Resolution of Chiral Amino Acids with Capillary Electrophoresis for Biosignature Detection in Extraterrestrial Samples
  Amino acids are fundamental building blocks of terrestrial life as well as ubiquitous byproducts of abiotic reactions. In order to distinguish between amino acids formed by abiotic versus biotic processes it is possible to use chemical distributions to identif…
  openalex Jessica S. Creamer, María F. Mora, Peter A. Willis, Maria F. Mora 2016-12-05 置信度 0.72 ChemistryAmino acidCapillary electrophoresisEnantiomerAbiotic component
• Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs and symptoms suggestive of TB
  BACKGROUND: User-friendly, rapid, inexpensive yet accurate TB diagnostic tools are urgently needed at points of care in resource-limited settings. We investigated host biomarkers detected in serum samples obtained from adults with signs and symptoms suggestive…
  openalex Novel N. Chegou, Jayne S. Sutherland, Stephanus T. Malherbe, Amelia C. Crampin 等 2016-05-04 置信度 0.72 MedicineDiseaseTuberculosisInternal medicineC-reactive protein
• Plasma biosignature and brain pathology related to persistent cognitive impairment in late-life depression
  openalex Breno S. Diniz, Etienne Sibille, Ying Ding, George C. Tseng 等 2014-08-05 置信度 0.72 Depression (economics)Late life depressionCognitive impairmentNeurosciencePsychology
• Effect of biological soil crusts on soil elemental concentrations: implications for biogeochemistry and as traceable biosignatures of ancient life on land
  Biological soil crusts (BSCs) are topsoil biosedimentary structures built by photosynthetic microbes commonly found today on arid soils. They play a role in soil stabilization and the fertility of arid lands, and are considered modern analogues of ancient terr…
  openalex Hugo Beraldi-Campesi, Hilairy E. Hartnett, Ariel D. Anbar, Gwyneth W. Gordon 等 2009-06-01 置信度 0.72 Soil waterBiogeochemistryAridTopsoilSoil fertility
• Biosignature Detection at an Arctic Analog to Europa
  The compelling evidence for an ocean beneath the ice shell of Europa makes it a high priority for astrobiological investigations. Future missions to the icy surface of this moon will query the plausibly sulfur-rich materials for potential indications of the pr…
  openalex D. F. Gleeson, R. T. Pappalardo, M. S. Anderson, Stephen E. Grasby 等 2012-01-27 置信度 0.72 AstrobiologyThe arcticArcticExoplanetRemote sensing
• Biosignatures of Exposure/Transmission and Immunity
  A blood test that captures cumulative exposure over time and assesses levels of naturally acquired immunity (NAI) would provide a critical tool to monitor the impact of interventions to reduce malaria transmission and broaden our understanding of how NAI devel…
  openalex Christopher L. King, D. Huw Davies, Phil Felgner, Elizabeth Baum 等 2015-08-11 置信度 0.72 MalariaPlasmodium falciparumTransmission (telecommunications)ImmunityImmunology
• Reassessing the biogenicity of Earth’s oldest trace fossil with implications for biosignatures in the search for early life
  Microtextures in metavolcanic pillow lavas from the Barberton greenstone belt of South Africa have been argued to represent Earth's oldest trace fossil, preserving evidence for microbial life in the Paleoarchean subseafloor. In this study we present new in sit…
  openalex Eugene G. Grosch, Nicola McLoughlin 2014-05-27 置信度 0.72 Greenstone beltTitaniteAstrobiologyArcheanGeology
• Multiple-Sulphur Isotope Biosignatures
  openalex Shuhei Ono 2007-10-05 置信度 0.72 Abiogenic petroleum originMeteoriteSulfurAstrobiologyIsotope
• Destruction of Raman biosignatures by ionising radiation and the implications for life detection on Mars
  openalex Lewis Dartnell, Kristian Page, Susana E. Jorge Villar, Gary Wright 等 2012-02-20 置信度 0.72 Deinococcus radioduransRaman spectroscopyMartianIonizing radiationMars Exploration Program
• Identification of eight-protein biosignature for diagnosis of tuberculosis
  Background Biomarker-based tests for diagnosing TB currently rely on detecting Mycobacterium tuberculosis (Mtb) antigen-specific cellular responses. While this approach can detect Mtb infection, it is not efficient in diagnosing TB, especially for patients who…
  europepmc Qianting Yang, Qi Chen, Mingxia Zhang, Yi Cai 等 2020 置信度 0.80 MedicineBiomarkerTuberculosisCohortMycobacterium tuberculosis
• Micrometer-scale porosity as a biosignature in carbonate crusts
  We formed calcite crusts in the presence and absence of the heterotrophic bacterium Desulfovibrio desulfuricans strain G20 to investigate microbial morphological signatures in fast-accreting carbonate precipitates. Submicrometer- to micrometer-sized pores (mic…
  openalex Tanja Bosak, Virginia Souza‐Egipsy, Frank A. Corsetti, Dianne K. Newman 等 2004-01-01 置信度 0.72 BoulevardArchaeologyGeologyLibrary scienceGeography
• Detecting Vascular Biosignatures with a Colloidal, Radio-Opaque Polymeric Nanoparticle
  A synthetic methodology for developing a polymeric nanoparticle for targeted computed tomographic (CT) imaging is revealed in this manuscript. The work describes a new class of soft type, vascularly constrained, stable colloidal radio-opaque metal-entrapped po…
  openalex Dipanjan Pan, Todd A. Williams, Angana Senpan, John S. Allen 等 2009-10-01 置信度 0.72 OpacityChemistryNanoparticleAmphiphileColloid
• Phosphine as a Biosignature Gas in Exoplanet Atmospheres
  A long-term goal of exoplanet studies is the identification and detection of biosignature gases. Beyond the most discussed biosignature gas O2, only a handful of gases have been considered in detail. In this study, we evaluate phosphine (PH3). On Earth, PH3 is…
  openalex Ribeiro De Sousa E Silva, Clara, Sara Seager, Sukrit Ranjan, Janusz J. Petkowski 等 2019-11-01 置信度 0.72 ExoplanetAstrobiologyOutgassingPlanetAtmosphere (unit)
• Is the Presence of Oxygen on an Exoplanet a Reliable Biosignature?
  We revisit the validity of the presence of O 2 or O 3 in the atmosphere of a rocky planet as being a biosignature. Up to now, the false positive that has been identified applies to a planet during a hot greenhouse runaway, which is restricted to planets outsid…
  openalex Alain Léger, Marc Fontecave, A. Labeyrie, B. Samuel 等 2011-05-01 置信度 0.72 ExoplanetAstrobiologyPlanetPlanetary habitabilityCircumstellar habitable zone
• Psychiatric patient stratification using biosignatures based on cerebrospinal fluid protein expression clusters
  openalex Giuseppina Maccarrone, Claudia Ditzen, Alexander Yassouridis, Christiane Rewerts 等 2013-08-17 置信度 0.72 Cerebrospinal fluidBipolar disorderMedicineDiseaseSchizophrenia (object-oriented programming)
• The curious consistency of carbon biosignatures over billions of years of Earth-life coevolution
  Abstract The oldest and most wide-ranging signal of biological activity (biosignature) on our planet is the carbon isotope composition of organic materials preserved in rocks. These biosignatures preserve the long-term evolution of the microorganism-hosted met…
  openalex Amanda K. Garcia, Colleen M. Cavanaugh, Betül Kaçar 2021-04-12 置信度 0.72 PhototrophExtant taxonAstrobiologyBiologyBiosphere
• Biosignatures link microorganisms to iron mineralization in a paleoaquifer
  Concretions, preferentially cemented masses within sediments and sedimentary rocks, are records of sediment diagenesis and tracers of pore water chemistry. For over a century, rinded spheroidal structures that exhibit an Fe(III) oxide-rich exterior and Fe-poor…
  openalex Karrie A. Weber, Trisha Spanbauer, David Wacey, Matt R. Kilburn 等 2012-06-17 置信度 0.72 Library scienceHistoryEnvironmental ethicsArt historyOperations research
• Biosignature for airway inflammation in a house dust mite-challenged murine model of allergic asthma
  ABSTRACT House dust mite (HDM) challenge is commonly used in murine models of allergic asthma for preclinical pathophysiological studies. However, few studies define objective readouts or biomarkers in this model. In this study we characterized immune response…
  openalex Hadeesha Piyadasa, Anthony Altieri, Sujata Basu, Jacquie Schwartz 等 2016-01-06 置信度 0.72 House dust miteAsthmaBiologyAllergic asthmaInflammation
• Assessing the utility of trace and rare earth elements as biosignatures in microbial iron oxyhydroxides
  Microbial iron oxyhydroxides are common deposits in natural waters, recent sediments and mine drainage systems and often contain significant accumulations of trace and rare earth elements (TREE). TREE patterns are widely used to characterize minerals and rocks…
  openalex Christine Heim, Klaus Simon, Danny Ionescu, Andreas Reimer 等 2015-02-24 置信度 0.72 Environmental chemistryArcheanAbiotic componentIron bacteriaGeology
• Potential Biosignatures in Super-Earth Atmospheres II. Photochemical Responses
  Spectral characterization of super-Earth atmospheres for planets orbiting in the habitable zone of M dwarf stars is a key focus in exoplanet science. A central challenge is to understand and predict the expected spectral signals of atmospheric biosignatures (s…
  openalex John Lee Grenfell, S Gebauer, M. Godolt, K. Palczynski 等 2013-05-01 置信度 0.72 Circumstellar habitable zoneExoplanetAstrobiologyPlanetPlanetary habitability
• Discovery and replication of a peripheral tissue DNA methylation biosignature to augment a suicide prediction model
  Suicide is the second leading cause of death among adolescents in the USA, and rates are rising. Methods to identify individuals at risk are essential for implementing prevention strategies, and the development of a biomarker can potentially improve prediction…
  openalex Makena Clive, Marco P. Boks, Christiaan H. Vinkers, Lauren M. Osborne 等 2016-11-03 置信度 0.72 Replication (statistics)AugmentHuman geneticsComputational biologyMethylation
• Microbial Morphology and Motility as Biosignatures for Outer Planet Missions
  Meaningful motion is an unambiguous biosignature, but because life in the Solar System is most likely to be microbial, the question is whether such motion may be detected effectively on the micrometer scale. Recent results on microbial motility in various Eart…
  pubmed Jay Nadeau, Chris Lindensmith, Jody W. Deming, Vicente I. Fernandez 等 2016 Oct 置信度 0.82 AstrobiologyPlanetExoplanetMorphology (biology)Biology