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• github.com/theiagen/public_health_bioinformatics/MashTree_FASTA_PHB
  Public Health Bioinformatics (PHB) The Public Health Bioinformatics Bioinformatics repository contains workflows for genomic characterization, submission preparation, and genomic epidemiology of pathogens of public health concern. Introduction Find the extensi…
  datacite theiagen 2026 置信度 0.66
• github.com/theiagen/public_health_bioinformatics/kSNP4_PHB
  Public Health Bioinformatics (PHB) The Public Health Bioinformatics Bioinformatics repository contains workflows for genomic characterization, submission preparation, and genomic epidemiology of pathogens of public health concern. Introduction Find the extensi…
  datacite theiagen 2026 置信度 0.66
• github.com/theiagen/public_health_bioinformatics/kSNP4_PHB
  Public Health Bioinformatics (PHB) The Public Health Bioinformatics Bioinformatics repository contains workflows for genomic characterization, submission preparation, and genomic epidemiology of pathogens of public health concern. Introduction Find the extensi…
  datacite theiagen 2026 置信度 0.66
• github.com/theiagen/public_health_bioinformatics/kSNP3_PHB
  Public Health Bioinformatics (PHB) The Public Health Bioinformatics Bioinformatics repository contains workflows for genomic characterization, submission preparation, and genomic epidemiology of pathogens of public health concern. Introduction Find the extensi…
  datacite theiagen 2026 置信度 0.66 theiagen-phb
• github.com/theiagen/public_health_bioinformatics/kSNP3_PHB
  Public Health Bioinformatics (PHB) The Public Health Bioinformatics Bioinformatics repository contains workflows for genomic characterization, submission preparation, and genomic epidemiology of pathogens of public health concern. Introduction Find the extensi…
  datacite theiagen 2026 置信度 0.66 theiagen-phb
• github.com/theiagen/public_health_bioinformatics/Freyja_Dashboard_PHB
  Public Health Bioinformatics (PHB) The Public Health Bioinformatics Bioinformatics repository contains workflows for genomic characterization, submission preparation, and genomic epidemiology of pathogens of public health concern. Introduction Find the extensi…
  datacite theiagen 2026 置信度 0.66
• github.com/theiagen/public_health_bioinformatics/Freyja_Dashboard_PHB
  Public Health Bioinformatics (PHB) The Public Health Bioinformatics Bioinformatics repository contains workflows for genomic characterization, submission preparation, and genomic epidemiology of pathogens of public health concern. Introduction Find the extensi…
  datacite theiagen 2026 置信度 0.66
• github.com/theiagen/public_health_bioinformatics/Freyja_Plot_PHB
  Public Health Bioinformatics (PHB) The Public Health Bioinformatics Bioinformatics repository contains workflows for genomic characterization, submission preparation, and genomic epidemiology of pathogens of public health concern. Introduction Find the extensi…
  datacite theiagen 2026 置信度 0.66
• github.com/theiagen/public_health_bioinformatics/Freyja_Plot_PHB
  Public Health Bioinformatics (PHB) The Public Health Bioinformatics Bioinformatics repository contains workflows for genomic characterization, submission preparation, and genomic epidemiology of pathogens of public health concern. Introduction Find the extensi…
  datacite theiagen 2026 置信度 0.66
• github.com/theiagen/public_health_bioinformatics/Freyja_FASTQ_PHB
  Public Health Bioinformatics (PHB) The Public Health Bioinformatics Bioinformatics repository contains workflows for genomic characterization, submission preparation, and genomic epidemiology of pathogens of public health concern. Introduction Find the extensi…
  datacite theiagen 2026 置信度 0.66
• github.com/theiagen/public_health_bioinformatics/NCBI_Scrub_PE_PHB
  Public Health Bioinformatics (PHB) The Public Health Bioinformatics Bioinformatics repository contains workflows for genomic characterization, submission preparation, and genomic epidemiology of pathogens of public health concern. Introduction Find the extensi…
  datacite theiagen 2026 置信度 0.66
• github.com/theiagen/public_health_bioinformatics/NCBI_Scrub_SE_PHB
  Public Health Bioinformatics (PHB) The Public Health Bioinformatics Bioinformatics repository contains workflows for genomic characterization, submission preparation, and genomic epidemiology of pathogens of public health concern. Introduction Find the extensi…
  datacite theiagen 2026 置信度 0.66
• github.com/theiagen/public_health_bioinformatics/VADR_Update_PHB
  Public Health Bioinformatics (PHB) The Public Health Bioinformatics Bioinformatics repository contains workflows for genomic characterization, submission preparation, and genomic epidemiology of pathogens of public health concern. Introduction Find the extensi…
  datacite theiagen 2026 置信度 0.66
• github.com/theiagen/public_health_bioinformatics/VADR_Update_PHB
  Public Health Bioinformatics (PHB) The Public Health Bioinformatics Bioinformatics repository contains workflows for genomic characterization, submission preparation, and genomic epidemiology of pathogens of public health concern. Introduction Find the extensi…
  datacite theiagen 2026 置信度 0.66
• github.com/theiagen/public_health_bioinformatics/Pangolin_Update_PHB
  Public Health Bioinformatics (PHB) The Public Health Bioinformatics Bioinformatics repository contains workflows for genomic characterization, submission preparation, and genomic epidemiology of pathogens of public health concern. Introduction Find the extensi…
  datacite theiagen 2026 置信度 0.66
• github.com/theiagen/public_health_bioinformatics/Augur_Prep_PHB
  Public Health Bioinformatics (PHB) The Public Health Bioinformatics Bioinformatics repository contains workflows for genomic characterization, submission preparation, and genomic epidemiology of pathogens of public health concern. Introduction Find the extensi…
  datacite theiagen 2026 置信度 0.66
• github.com/theiagen/public_health_bioinformatics/Augur_PHB
  Public Health Bioinformatics (PHB) The Public Health Bioinformatics Bioinformatics repository contains workflows for genomic characterization, submission preparation, and genomic epidemiology of pathogens of public health concern. Introduction Find the extensi…
  datacite theiagen 2026 置信度 0.66
• github.com/theiagen/public_health_bioinformatics/Augur_PHB
  Public Health Bioinformatics (PHB) The Public Health Bioinformatics Bioinformatics repository contains workflows for genomic characterization, submission preparation, and genomic epidemiology of pathogens of public health concern. Introduction Find the extensi…
  datacite theiagen 2026 置信度 0.66
• github.com/theiagen/public_health_bioinformatics/Terra_2_NCBI_PHB
  Public Health Bioinformatics (PHB) The Public Health Bioinformatics Bioinformatics repository contains workflows for genomic characterization, submission preparation, and genomic epidemiology of pathogens of public health concern. Introduction Find the extensi…
  datacite theiagen 2026 置信度 0.66
• github.com/theiagen/public_health_bioinformatics/Terra_2_NCBI_PHB
  Public Health Bioinformatics (PHB) The Public Health Bioinformatics Bioinformatics repository contains workflows for genomic characterization, submission preparation, and genomic epidemiology of pathogens of public health concern. Introduction Find the extensi…
  datacite theiagen 2026 置信度 0.66
• github.com/theiagen/public_health_bioinformatics/Mercury_Prep_N_Batch_PHB
  Public Health Bioinformatics (PHB) The Public Health Bioinformatics Bioinformatics repository contains workflows for genomic characterization, submission preparation, and genomic epidemiology of pathogens of public health concern. Introduction Find the extensi…
  datacite theiagen 2026 置信度 0.66
• github.com/theiagen/public_health_bioinformatics/Mercury_Prep_N_Batch_PHB
  Public Health Bioinformatics (PHB) The Public Health Bioinformatics Bioinformatics repository contains workflows for genomic characterization, submission preparation, and genomic epidemiology of pathogens of public health concern. Introduction Find the extensi…
  datacite theiagen 2026 置信度 0.66
• Large-scale mutational analysis uncovers molecular mechanisms governing dual RNA functions in transposons.
  Transposons are among the most abundant mobile genetic elements in nature. IStrons are a unique class of transposons, encoding a transposase for transposon mobility, an RNA-guided nuclease for maintenance, and a self-splicing group I intron for element removal…
  pubmed Mortman EE, Sternberg SH 2026 Aug 24 置信度 0.82
• Ultraviolet-B-induced OsKOL4 promotes ABA accumulation by inhibiting OsABA8ox1 and OsABA8ox2 expression.
  Ultraviolet-B (UV-B) light is a component of sunlight that influences plant survival and adaptation. UV-B induces plants to regulate their phenotypes and metabolism to increase resistance to UV-B and associated stresses. Abscisic acid (ABA) metabolism and sign…
  pubmed Liu K, Chen H, Qadir M, Wang L 2026 Aug 28 置信度 0.82
• Exploring the evolutionary conservation of SCR-SHR and RBR-SCR interactions across Viridiplantae.
  In Arabidopsis thaliana, one of the most important gene families involved in plant development is the one encoding the GRAS transcription factors. In this family, SHORT-ROOT (SHR) and SCARECROW (SCR) play key roles in asymmetric cell division and the maintenan…
  pubmed Domingo MÁ, Alfredo CR 2026 Aug 28 置信度 0.82
• [Type 2 Macular Telangiectasia: Pathogenesis-The Interplay Between Neurodegeneration and Metabolic Changes].
  Macular telangiectasia type 2 (MacTel type 2) is a rare, chronic neurodegenerative macular disease that typically occurs bilaterally in the second half of life. Patients report paracentral scotomas and reading difficulties early in the disease course. Over tim…
  pubmed Jung M, Bucher F 2026 Aug 27 置信度 0.82
• Traumatic Brain Injury: Multi-Omics Insights into Brain Aging, Neurodegeneration, and Precision Therapeutics.
  Traumatic brain injury (TBI) is a major cause of mortality and persistent neurological disability and is increasingly recognized as a potential contributor to accelerated brain aging and long-term neurodegenerative processes. Beyond the immediate mechanical in…
  pubmed Shafie A, Ashour AA, Alhujaily MM, Anjum F 等 2026 Aug 27 置信度 0.82
• Somatic genomic mosaicism in chronic kidney disease progression: A graded appraisal of renal epithelial injury, cellular senescence, and therapeutic implications.
  To appraise, and grade by strength of evidence, whether somatic genomic mosaicism contributes to chronic kidney disease (CKD) progression, and to separate mosaicism arising within kidney tissue from clonal alterations arising in blood.
  pubmed Cao H, Wu Q, Wang Z, Ye C 等 2026 Aug 27 置信度 0.82
• Contrasting redox-related physiological responses associated with HaGATA23 and HaGATA36 during Orobanche cumana parasitism in sunflower (Helianthus annuus L.).
  Helianthus annuus is an economically important Asteraceae species used for seed oil production and ornamental purposes, but its production is seriously affected by the root-parasitic plant Orobanche cumana. GATA transcription factors are zinc-finger DNA-bindin…
  pubmed Fu Y, Zhou T, Zhang S, Su S 等 2026 Aug 27 置信度 0.82
• Genetic variation in oxidative stress and detoxification pathways associated with prostate cancer susceptibility: a pathway-based analysis.
  Redox imbalance and impaired detoxification pathways have been implicated in prostate carcinogenesis; however, the specific genetic variants that modulate these processes remain insufficiently characterized. We used a two-stage, pathway-focused design in which…
  pubmed Álvarez-González B, Morales-Álvarez CM, Porras-Quesada P, Chica-Redecillas L 等 2026 Aug 27 置信度 0.82
• Complementary activity of an ancient combination of natural ingredients on the dysbiosis symptoms linked to acne.
  Acne is one of the most common dermatologic diseases in the world. It is due to the secretion of a high level of sebum that causes follicular hyperkeratinisation, alterations of the cutaneous microbiota, and inflammatory processes. One of the first-line treatm…
  pubmed Janel R, Ortet L, Mahjoub S, Braillon C 等 2026 Aug 27 置信度 0.82
• Morphologic correlates of genetic subtypes of acute myeloid leukemia.
  Acute myeloid leukemia (AML) is increasingly defined by recurrent genetic alterations that determine disease classification, prognosis, and therapeutic strategy. Although definitive diagnosis of genetically defined subtypes relies on cytogenetic and molecular …
  pubmed Anderson-Calleja J, Ehyaee V, Mirza KM 2026 Aug 27 置信度 0.82
• Transmission dynamics of Neisseria gonorrhoeae in Greenland: a 55-year retrospective observational study.
  Greenland has high gonorrhoea rates, yet the antimicrobial resistance (AMR) and especially genomic epidemiology and dynamics of gonococcal lineages remain unexplored. We characterized circulating gonococcal lineages in Greenland over 55 years, their AMR determ…
  pubmed Sánchez-Serrano A, Golparian D, Pedersen TR, Hoffmann S 等 2026 Aug 27 置信度 0.82
• Mechanistic characterization and inhibition of PAD4-dependent NETosis following experimental neonatal hypoxic-ischemic brain injury.
  Neonatal hypoxia-ischemia (HI) remains a major global cause of neonatal morbidity and mortality. To develop effective therapeutic strategies, a deeper understanding of the acute inflammatory processes following HI is required. As the role of peripheral immune …
  pubmed Bremer AS, Bernis ME, Burkard H, Maes E 等 2026 Aug 27 置信度 0.82
• Recent trends in nucleic acid research in plants for future food security.
  The agricultural production system is facing unprecedented pressure of climate change, human population, pressure on renewable and non-renewable resources, and elevation in both biotic and abiotic stress factors. The recent development in nucleic acid based te…
  pubmed Fiaz S 2026 Aug 27 置信度 0.82
• Bidirectional and regiospecific C21-modification of steroids by a chloramphenicol O-acetyltransferase.
  Bidirectional acetylation and deacetylation of small molecules by acetyltransferases (ATs) remain poorly understood. In this study, we present the structural, functional, and computational characterization of a chloramphenicol O-AT from Bacillus sp. PAMC22265 …
  pubmed Regmi KP, Park S, Paudel P, Park HS 等 2026 Aug 27 置信度 0.82
• Elafibranor in primary biliary cholangitis: two-year placebo-controlled outcomes and long-term open-label data from the ELATIVE® phase III trial.
  We report 104-week placebo-controlled data and long-term open-label extension (OLE) data from the ongoing ELATIVE® phase III trial (NCT04526665) of elafibranor in primary biliary cholangitis (PBC).
  pubmed Kowdley KV, Bowlus CL, Levy C, Akarca U 等 2026 Aug 27 置信度 0.82
• Integrative multi-omics identifies cholangiolocarcinoma as a distinct molecular subtype of intrahepatic cholangiocarcinoma.
  Intrahepatic cholangiocarcinoma (iCCA) exhibits profound heterogeneity, complicating its clinical management. This study aims to define the molecular features underlying its histological subtypes to better understand their biology and identify potential therap…
  pubmed Chen J, Gao X, Chen T, Dai T 等 2026 Aug 27 置信度 0.82
• Targeting the TL1A pathway in inflammatory bowel disease: mechanistic insights and emerging therapeutic pipeline.
  Tumor necrosis factor-like ligand 1A (TL1A), encoded by TNFSF15, signals through death receptor 3 on effector T cells, innate lymphoid cells, and intestinal myofibroblasts, driving both chronic intestinal inflammation and tissue fibrosis. In this narrative rev…
  pubmed Quraishi MN, Jairath V, Al-Bawardy B 2026 Aug 27 置信度 0.82
• Genomic analysis of Echinococcus granulosus sensu stricto: genetic diversity and population structure.
  Cystic echinococcosis, caused by the tapeworm Echinococcus granulosus sensu stricto (ss), is a globally distributed, zoonotic disease that is recognised by WHO as a neglected tropical disease. Despite its clinical and economic importance, nuclear genomic varia…
  pubmed Anijalg L, Korhonen PK, Young ND, Cai H 等 2026 Aug 27 置信度 0.82
• Beyond maximum grade: the role of real-world digital health technologies to capture, predict, and manage treatment toxicity in haematological cancers.
  Real-world data are essential for understanding treatment-related toxicities in haematology, but traditional analyses are limited by data access, sharing constraints, and reduced data granularity. Emerging digital health technologies (DHTs), such as electronic…
  pubmed El-Galaly TC, Buvat I, Córdoba R, Porta MGD 等 2026 Sep 置信度 0.82
• Shared ligand-blocking mechanism but distinct conformational modulation by α5-targeting antibodies BIIG2 and MINT1526A.
  Integrins are heterodimeric receptors important for cell adhesion and signaling. Integrin α5β1 is a key mediator of angiogenesis and its dysregulation is associated with tumor progression and metastasis. Despite numerous efforts, α5β1-t…
  pubmed Nguyen A, Heim JB, Cordara G, Chan MC 等 2026 Aug 27 置信度 0.82
• Approach to the Landscape of Bacterial Diseases in Wayuu Communities, Colombia: Acute Diarrheal Disease and Febrile Bacterial Syndromes.
  Indigenous communities face a disproportionate burden of neglected communicable diseases, particularly acute diarrheal disease (ADD) and bacterial febrile illness (BFI), in contexts with limited access to diagnosis and medical care. The circulation of bacteria…
  pubmed Díaz-Guevara PL, Alarcón Z, Flórez-Delgado NY, Montaño LA 等 2026 Aug 27 置信度 0.82
• Routine methods misidentify Serratia spp.: Limitations of MALDI-TOF MS revealed by whole-genome sequencing.
  Accurate species-level identification within the genus Serratia remains challenging due to extensive phenotypic overlap and high genomic relatedness among closely related and recently described taxa. This study presents an evaluation of routine and genome-base…
  pubmed Felício IM, Vianna EF, Almeida MM, Abreu JO 等 2026 Aug 23 置信度 0.82
• DNA methylation landscape of cerebrospinal fluid cells in multiple sclerosis: an epigenome-wide association study.
  Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system in which DNA methylation may link genetic and environmental risk factors.
  pubmed Han Y, Zheleznyakova GY, Liang H, Sorini C 等 2026 Aug 27 置信度 0.82
• The impact of EGFR subtype combined with TP53 co-mutation status on survival outcomes with front-line osimertinib in non-small cell lung cancer (NSCLC).
  Osimertinib is a standard therapy for EGFR-mutant NSCLC. However, markers to better identify those at risk for poor outcomes are needed. This is the largest study to date evaluating the impact of EGFR subtype combined with TP53 co-mutation status on survival e…
  pubmed Kim HS, Zhang L, Bodor JN, Clapper ML 等 2026 Aug 14 置信度 0.82
• Association between opioid agonist therapy and pharmacotherapy for mental disorders among people living with HIV and co-occurring opioid use and mental disorders.
  People living with HIV (PLWH) with co-occurring opioid use disorder (OUD) and mental disorders experience fragmented care. Opioid agonist therapy (OAT) is central to treating OUD and improves engagement in HIV care; however, its role in facilitating mental dis…
  pubmed Yazdani K, Wang X, Tam C, Emerson SD 等 2026 Aug 27 置信度 0.82
• Oncotype DX-guided vs physician-directed chemotherapy and survival in HR+/HER2- breast cancer.
  Oncotype DX testing guides adjuvant chemotherapy decisions in early-stage hormone receptor-positive/HER2-negative breast cancer, but testing is not universally performed, and outcomes associated with genomic-informed versus clinicopathologic-based chemotherapy…
  pubmed Li J, Han X, Zhuang Y, Liu Y 等 2026 Aug 23 置信度 0.82
• The truncated Tau fragment 315-441 produced by Caspase-2 translocates to the nucleus and alters the proteome of neuroblastoma cells.
  Alzheimer's disease (AD) symptoms arise from significant loss of neurons in the hippocampal region and the entorhinal cortex. This neuronal death is primarily caused by the abnormal aggregation of Tau protein into paired helical filaments within the somatodend…
  pubmed López-Aviña YI, Ríos-Castro E, Rodríguez-Cruz F, Mendoza-Franco G 等 2026 Aug 23 置信度 0.82
• Targeting SUV4-20H2-mediated H4K20 methylation restrains growth and migration in pediatric high-grade astrocytomas.
  Pediatric astrocytomas are characterized by increased molecular and clinical heterogeneity with epigenetic alterations contributing to aggressiveness and therapy resistance. The repressive histone mark H4K20 trimethylation (H4K20me3) and the methyltransferase …
  pubmed Giannopoulou AI, Kosma E, Kanakoglou DS, Klonou A 等 2026 Aug 27 置信度 0.82
• New Natural Product Antibiotics: Strategies and Tools That Offer New Approaches to Overcome Traditional Roadblocks.
  Microbial natural products have been the cornerstone of antibiotics used in medicine since their discovery in the early twentieth century. Shaped by natural selection, natural products are privileged compounds that often target complex biological systems. Desp…
  pubmed George MSB, Balea MI, Wright GD 2026 Aug 27 置信度 0.82
• Structural failure in cereal stems under climate extremes: insights from barley head loss.
  Structural failure of cereal stems during late-season climate extremes is a critical determinant of yield stability. In barley, breakage of the stem below the spike, known as head loss, leads to major yield losses, particularly in hot and dry regions where the…
  pubmed Rajendran NR, Rabanus-Wallace MT, Lu J, Fincher GB 等 2026 Aug 27 置信度 0.82
• Demographics and factors influencing mortality among cardiac angiosarcoma patients and genomic studies correlation for future personalized management.
  Cardiac angiosarcoma is a rare, highly aggressive malignancy arising from endothelial cells of the heart and accounts for ∼30% of primary cardiac tumors. Understanding its epidemiology and factors influencing mortality is critical, and emerging genomic …
  pubmed Ullah A, Wali A, Bansal PK, Fadhil N 等 2026 Aug 27 置信度 0.82
• Genomic Landscape of Metastatic Urothelial Cancer in a Multicenter Cohort From Argentina.
  The genomic landscape of advanced urothelial carcinoma (aUC) has enabled the development of targeted therapies; however, real-world data from Latin America remain limited.
  pubmed Cayol F, Macharashvili I, Barochiner J, Dominguez MP 等 2026 Aug 置信度 0.82
• Refined Continuous Risk Index for Accurately Predicting Outcomes of Patients With Chronic Lymphocytic Leukemia After Limited-Duration Therapy.
  Measurable residual disease (MRD) status after limited-duration treatment for chronic lymphocytic leukemia (CLL) strongly predicts survival times and is considered a surrogate end point. However, most prognostic indices, including the International Prognostic …
  pubmed Al-Sawaf O, Zhang C, Esfahani MS, Liu CL 等 2026 Aug 27 置信度 0.82
• [Recommendations for the diagnosis and treatment of optic neuromyelitis in children and adolescents].
  Neuromyelitis Optica spectrum disorder (NMOSD) is a severe autoimmune disease of the central nervous system characterized primarily by inflammation of the optic nerve, spinal cord, and brainstem. The identification of IgG antibodies against aquaporin-4 (AQP4-I…
  pubmed Quito-Betancourt B, Contreras J, Espinel F, Acosta MT 2026 Aug 置信度 0.82
• [Tics and Tourette Syndrome].
  Tics disorders and Tourette syndrome (TS) are neurodevelopmental conditions characterized by motor and/or vocal tics with onset in childhood. Their clinical presentation is heterogeneous and fluctuating over time, with exacerbations related to emotional, envir…
  pubmed Quito-Betancourt B, Acosta MT, Arroyo HA, Cerisola A 等 2026 Aug 置信度 0.82
• Advances in the development of a vaccine for the prevention of human leptospirosis: a review.
  Leptospirosis is a zoonosis with global distribution caused by spirochetes of the genus Leptospira. In regions with poor sanitation, leptospirosis is considered a neglected disease, resulting in approximately one million cases and thousands of deaths annually.…
  pubmed Jesus MS, Almeida MEM, Mariúba LAM 2026 置信度 0.82
• Bulk and single cell RNA sequencing data reveal lactylation-related gene signatures for prognosis and immunity in cervical cancer.
  Previous studies indicate that lactylation, a post-translational modification, may play an important role in the progression of cervical cancer (CC). However, the comprehensive roles of lactylation in influencing the tumor microenvironment, immune landscape, a…
  pubmed Song J, Zhao Y, Dong C, Qi X 等 2026 置信度 0.82
• PSIP1::TBL1X: a recurrent gene fusion in pancreatic neuroendocrine tumors.
  Effective treatment of metastatic neuroendocrine tumors (NETs) is limited by a lack of targeted therapies and clinically useful predictive biomarkers. We applied complementary genomic profiling technologies, including optical genome mapping (OGM) and whole exo…
  pubmed Ackerman D, Seyferth ER, Li W, Youngman JE 等 2026 Aug 27 置信度 0.82
• Natural variation and uORF engineering complementary routes to improve ascorbic acid accumulation in tomato.
  Ascorbic acid (AsA) determines fruit nutritional quality and antioxidant capacity in tomato, but available genetic resources for its improvement are limited. Here, we integrated natural variation analysis with upstream open reading frames (uORFs) editing to id…
  pubmed Wang J, Xie Z, Zheng H, Tang H 等 2026 Aug 4 置信度 0.82
• Genomic predisposition is associated with the direction of sex chromosome evolution.
  Sex chromosome evolution is among the most dynamic genomic innovations in vertebrates, yet why some lineages evolve XY while others evolve ZW remains unclear. Using chromosome-level genomes from 19 geckos, we found that gecko sex chromosomes originated indepen…
  pubmed Zhou Y, Jin J, Jiang C, Dudchenko O 等 2026 Aug 27 置信度 0.82
• Beyond wrinkles.
  Can the skin microbiome shape healthy aging?
  pubmed Jalili S, Oh J 2026 Aug 27 置信度 0.82
• Autism mutations rewire protein interaction networks to drive neurodevelopmental pathology.
  Systematic mapping of protein-protein interaction (PPI) networks and determining how causal mutations rewire them in autism spectrum disorder (ASD) provide a powerful framework for uncovering disease mechanisms and therapeutic opportunities. Using affinity pur…
  pubmed Wang B, Vartak R, Hennick KM, Zaltsman Y 等 2026 Aug 27 置信度 0.82
• A tripartite genetic conflict system controls hybrid sterility in rice.
  Interspecific Asian-African hybrid rice could substantially boost yield but is limited by severe hybrid sterility. We identify RHS3 as a major quantitative trait locus controlling this trait. RHS3 encodes a tripartite toxin-antidote system composed of MAO, DUN…
  pubmed He X, Zhao Z, Shao K, Yu X 等 2026 Aug 27 置信度 0.82
• Genotype-Driven MRI Re-evaluation Reveals Subtle PAFAH1B1-Related Lissencephaly.
  pubmed Xiol C, Olival J, Martorell L, Gómez-Chiari M 等 2026 Aug 27 置信度 0.82
• Pervasive context-dependent effects in the genetic architecture of complex and quantitative traits revealed by a powerful multiparent mapping population in yeast.
  The genetic dissection of complex traits remains a major challenge in basic and biomedical research, but is essential for understanding the molecular pathways that shape phenotypic variation and for developing predictive models of trait and disease susceptibil…
  pubmed Cromie GA, Lo RS, Ames L, Morgan TS 等 2026 Aug 27 置信度 0.82
• Development and validation of the 6-dye lyophilized fluorescent multiplex PCR system.
  Aiming to address the issues associated with traditional liquid STR reagents-such as dependence on cold-chain storage, cumbersome operation, and unsuitability for on-site rapid detection-this study has successfully developed a six-color fluorescent lyophilized…
  pubmed Cui Y, Zhang Z, Yu H, Ji M 等 2026 置信度 0.82
• Breastmilk microbiota and its association with infant iron deficiency anaemia: A 16S rRNA metagenomic study in Peruvian mothers cohort.
  Anaemia is one of the most important public health challenges in developing countries. The global burden is estimated at 1.8 billion people, affecting approximately 30% of all children. Despite the implementation of multiple strategies over several decades, up…
  pubmed Gonzales-Rodriguez AO, Gonzales-Huerta LE, Wong Chero PA, Vera-Silva LE 等 2026 置信度 0.82
• Extracting adverse event nature, severity, timelines and resulting interventions from clinical notes of patients receiving CAR-T cell therapy using large language models.
  Chimeric Antigen Receptor T-cell (CAR‑T) therapy, genetically engineered patient T cells targeting tumor antigens, has transformed care for hematologic malignancies but requires careful tracking of adverse events (AEs) often documented only in unstructu…
  pubmed Guillot J, Miao B, Suresh A, Sushil M 等 2026 Aug 置信度 0.82
• Carbon substrate type shapes spatial self-organization in a multi-species biofilm community.
  Spatial organization is a defining feature of multispecies biofilms and critically influences microbial interactions and emergent community properties. However, understanding and manipulating how microbes assemble into spatially structured biofilms remains cha…
  pubmed Zhu D, Svagan AJ, Yang N, Hansen MF 等 2026 Aug 27 置信度 0.82
• Enrichment and Characterization of a Haloalkaline-tolerant Anammox Bacterium.
  Metagenomic surveys have substantially expanded the known diversity of anaerobic ammonium-oxidizing (anammox) bacteria. However, the physiological traits of newly proposed anammox genera remain largely hypothetical due to the lack of cultured representatives. …
  pubmed Chuang HY, Wu JH, Chen SH, Chen WY 等 2026 Aug 27 置信度 0.82
• Methodological insights and clinical outcomes in ALS and FTLD: lessons from the SPIN cohort.
  Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) constitute a clinico-genetic-neuropathological continuum with marked heterogeneity. Reliable in vivo biomarkers of the disease are lacking. Large, multimodal cohorts are needed to…
  pubmed Carbayo Á, Turon-Sans J, Alcolea D, Cortés-Vicente E 等 2026 Aug 置信度 0.82
• Little sharks in a genomic world: A high-resolution view of population structure in the California horn shark (Heterodontus francisci).
  The California horn shark (Heterodontus francisci) is a small demersal elasmobranch distributed along Pacific coastlines from California to Mexico, including several nearshore islands. Previous analyses of mitochondrial control region (mtCR) variation indicate…
  pubmed Canfield SJ, Galván-Magaña F, Bowen BW 2026 Aug 27 置信度 0.82
• Advancing Homologous Recombination Repair Mutation Testing in Prostate Cancer in Australia: Shifting the Focus to Hormone Sensitive Prostate Cancer.
  Homologous recombination repair (HRR) gene alterations are key drivers of disease in prostate cancer. This has led to great interest in HRR targeted therapies, particularly polyadenosine diphosphate-ribose inhibitors (PARPi), in the treatment of metastatic cas…
  pubmed Azad AA, Murphy DG, Kwan EM, Joshua AM 2026 Aug 27 置信度 0.82
• Genetic control of local mutation rates.
  Mutations are the source of evolutionary novelty but also the cause of genetic diseases and cancer. Mutation rates are known to be heterogeneous along the genome, however the extent to which local mutation rates vary among individuals in a population and are g…
  pubmed Caballero M, Koren A 2026 Sep 置信度 0.82
• Structural biology of retron-mediated immunity against phage.
  Retrons recently emerged as widespread anti-phage systems in which a dedicated reverse transcriptase (RT) produces multicopy single-stranded DNA (msDNA) that regulates associated effector proteins. Once regarded as peculiar retroelements of unknown function, r…
  pubmed Jasnauskaitė M, Pausch P 2026 Aug 28 置信度 0.82
• Uncovering species- and drug-class-specific antimicrobial resistance mechanisms from large-scale whole-genome sequencing data using discordance analysis and machine learning.
  Whole-genome sequencing has become the standard molecular platform for antimicrobial resistance surveillance, yet existing computational approaches-gene catalogs that ignore expression, k-mer machine learning (ML) that lacks mechanistic interpretability, and S…
  pubmed Cheon NJ, Cuong Nguyen X, Unno T 2026 Jul 3 置信度 0.82
• Beyond Fixed False Discovery Rates: Post-Hoc Conformal Selection With E-Variables.
  Conformal selection (CS) uses calibration data to identify test inputs whose unobserved outcomes are likely to satisfy a pre-specified minimal quality requirement, while controlling the false discovery rate (FDR). Existing methods fix the target FDR level befo…
  pubmed Zhu M, Simeone O 2026 Aug 27 置信度 0.82
• Protocol for histology-anchored macroscopic staging of gonadal maturity in exploited fishes.
  Here, we present a protocol to assign gonadal maturity stages in commercially exploited fishes using a histology-anchored workflow. We describe steps for recording field metadata, photographing gonads, fixing central gonadal tissue, and processing paraffin sec…
  pubmed Santos R, Cruz M, Medeiros-Leal W, Rosa MD 等 2026 Aug 27 置信度 0.82
• Complete genome-derived metabolic interactions reveal the impact of gut ecology on human health.
  Metabolic interactions govern gut microbiome assembly, yet their functional rules remain obscured by genomic incompleteness and fragmentation. Here, we leverage 1,150 complete genomes to construct genome-scale metabolic models, demonstrating that draft assembl…
  pubmed Gu Y, Wang H, Yang J, Zeng T 等 2026 Aug 27 置信度 0.82
• nf-core/pacsomatic: a scalable somatic analytic pipeline using PacBio HiFi data.
  Pacific Biosciences (PacBio) HiFi long-read sequencing enables robust characterization of complex genomic regions, repetitive elements, and structural variants (SVs) that are often inaccessible to short-read technologies. To fully leverage HiFi reads to advanc…
  pubmed Zhang W, Yi H, Niu B, Wu G 等 2026 Aug 27 置信度 0.82
• The GENIE Data Model: A Solid Tumor, Person-Centric Framework for Scalable, Harmonized Precision Oncology Data Collection.
  Adequately powered analyses in precision oncology often require combining cohorts across institutions. Yet integration is constrained by the least granular source and may become infeasible when data elements are too heterogeneous to harmonize and map to a comm…
  pubmed Hoppe JN, Lee J, Akinyemiju TF, Bitterman DS 等 2026 Aug 27 置信度 0.82
• Cytosolic Fe/S protein biogenesis: a crossroads of Fe/S cluster machineries.
  Iron-sulfur (Fe/S) clusters are essential inorganic cofactors required for nearly all organisms. These cofactors do not spontaneously form in cells or on proteins; they require at least one of six dedicated Fe/S protein biogenesis pathways. The eukaryotic cyto…
  pubmed Braymer JJ 2026 Aug 28 置信度 0.82
• Current knowledge and use of pharmacogenomics among NPs: An integrative review.
  Pharmacogenomics, a critical component of precision medicine, is rapidly transforming health care by tailoring drug therapy based on individual genetic profiles. Nurse practitioners (NPs), as frontline providers and prescribers, play a key role in implementing…
  pubmed Whitten D, Courtney M, Courtney M, Fournier J 等 2026 Aug 27 置信度 0.82
• Unlocking Growth: Muscle-Bone Interactions in Cystinosis.
  pubmed Salcedo-Giraldo J, Gulati A 2026 Aug 1 置信度 0.82
• High-Resolution Imaging of RPE Cellular Mosaic Over Drusen.
  This case report of a patient aged 37 years with asymptomatic bilateral drusen discusses how adaptive optics transscleral flood illumination imaging enabled in vivo has the potential to detect subtle retinal pigment epithelial (RPE) changes in patients with dr…
  pubmed Lombardo M, Cascella R, Cusumano A 2026 Aug 27 置信度 0.82
• Identifying Patients at Risk for Psychotherapy Dropout in Community Settings.
  Psychotherapy dropout poses a significant public health problem and is associated with depression relapse and illness persistence. Identifying who is at risk of psychotherapy dropout can guide personalized and scalable strategies to mitigate risk and improve o…
  pubmed Giber B, Sharma A, Broadie D, McCoy TH Jr 等 2026 Aug 3 置信度 0.82
• Clonal hematopoiesis of indeterminate potential and metabolic dysfunction-associated steatotic liver disease: Korean biopsy cohort.
  Clonal hematopoiesis of indeterminate potential (CHIP) has emerged as a contributor to age-related diseases; however, its clinical relevance to metabolic liver disease remains to be established. This study investigated the association between CHIP and metaboli…
  pubmed Lee YK, Sim H, Joo SK, Jang H 等 2026 Aug 27 置信度 0.82
• Ovarian ageing: from biological constraint to emerging therapeutic frontier.
  Ovarian ageing is a central determinant of female reproductive potential, defined by a progressive and largely irreversible decline in both the quantity and the quality of oocytes. Although the process is universal, its onset and pace vary widely, and early ov…
  pubmed Mondal R, Nandi M 2026 Aug 27 置信度 0.82
• Complete Genome Sequence Analysis, Probiotic Properties, and Safety Assessment of Healthy Human-Derived Pediococcus pentosaceus.
  The probiotic potential of microorganisms is generally strain-specific and requires comprehensive evaluation at the strain level. In this study, two human-derived Pediococcus pentosaceus strains, MIANGUAN and MIANGUAN2, which have previously demonstrated benef…
  pubmed Chen Y, Shi H, Zhang H, Chen M 等 2026 Aug 27 置信度 0.82
• Uncovering the Role of Biological Sex in the Divergent Genetic Profiles of Early and Late-Diagnosed.
  Autism is a neurodevelopmental disorder with a significant male prevalence bias. While recent evidence suggests that genetic heterogeneity is indexed by age at diagnosis, males are also typically diagnosed earlier, such that the extent to which these age-speci…
  pubmed Breunig S, Schaffer L, Lawrence J, Sheppard A 等 2026 Aug 27 置信度 0.82
• Detection, isolation, and co-infection of parainfluenza virus 5 and porcine teschovirus 4 in colostrum-deprived piglets in Russia.
  In recent years, parainfluenza virus 5 (PIV5) and porcine teschoviruses (PTVs) have been commonly identified during respiratory and enteric pathologies in industrial pig farming. While these viruses are widespread in pig populations of many countries, little i…
  pubmed Anoyatbekova A, Krasnikov N, Polyakova I, Yuzhakov A 2026 Aug 27 置信度 0.82
• Establishment of a patient-derived malignant peripheral nerve sheath tumor organoid model reveals SHH pathway activation and therapeutic vulnerability.
  Malignant peripheral nerve sheath tumor (MPNST) is a rare and aggressive soft tissue sarcoma of presumed peripheral nerve sheath origin, for which effective systemic therapies remain limited. The biological mechanisms underlying its progression and therapeutic…
  pubmed Matsuoka H, Yoshida K, Matsuoka Y, Sasagawa S 等 2026 Aug 27 置信度 0.82
• Protein regulation mechanism of Haemaphysalis longicornis in response to high temperature.
  Ticks, as obligate blood-sucking ectoparasitic arthropods, are closely tied to ecosystem stability. High ambient temperatures can profoundly affect tick survival and reproduction by influencing individual behavior, population physiology, and adaptive evolution…
  pubmed Wang N, Zhang B, Yang P, Zhao Z 等 2026 Aug 27 置信度 0.82
• Evidence of natural bovine leukemia virus infection in llamas coexisting with cattle.
  During the last decades, camelid-derived products have gained increasing appreciation, positioning camelids within an emerging industry in several regions of the world. Their production in non-traditional areas creates new epidemiological scenarios due to inte…
  pubmed Lendez PA, Illia MC, Illia MPC, Zimmermann B 等 2026 Aug 27 置信度 0.82
• GASA/snakin proteins in plants: structural conservation, phylogenomic expansion, and functional diversity.
  Plant GASA/Snakin proteins (GASA: Gibberellic Acid-Stimulated Arabidopsis) constitute a family of secreted cysteine-rich peptides. The family is defined by 12 highly conserved cysteine residues forming up to six disulfide bonds within a thermostable helical sc…
  pubmed Abdullah, Heidari P 2026 Aug 27 置信度 0.82
• Identification and differential expression analysis of Hfq-bound novel small RNAs in Serratia marcescens by nitrocellulose-based partitioning.
  The rising prevalence of multidrug-resistant bacteria poses a looming threat to healthcare and necessitates novel therapeutic strategies beyond conventional antibiotics. One such organism is Serratia marcescens, which possesses a broad range of virulence facto…
  pubmed Vickineshwari K, Kishan Raj SR, Chinni SV, Citartan M 等 2026 Aug 27 置信度 0.82
• From molecular responses to environmental monitoring: advances and translational gaps in omics approaches in fish environmental toxicology.
  Fish occupy a central position in aquatic ecosystems and serve as important bioindicators for environmental monitoring, as well as powerful translational models for understanding toxic mechanisms conserved across higher vertebrates. In recent years, omics tech…
  pubmed Atri A, Sharma M, Rana V, Singh V 等 2026 Aug 27 置信度 0.82
• Pan-genomic analysis of the multi-drug resistant strains of Mycobacterium tuberculosis.
  Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) remains one of the most critical infectious diseases worldwide. The emergence of multi-drug resistant tuberculosis (MDR-TB) continues to pose a significant challenge to effective treatment and diseas…
  pubmed Anandan N, Venkatachalam R, Sundar S 2026 Aug 27 置信度 0.82