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2015-08-14T19:11:03Z
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Understanding the mapping of genotypes into phenotypes is a central challenge of current biological research. Such mapping, conceptually represents a developmental mechanism through which phenotypic variation can be generated. Given the nongenetic character of…
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2013-12-06T20:48:48Z
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ABSTRACT Whether new pancreatic beta-cells arise via pre-existing beta-cells or from differentiation of precursor cells − a question of fundamental importance for diabetic therapy − has long been debated. Recent experiments suggest that multipotent precursors …
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2021-05-03T17:53:17Z
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Computational models can serve many purposes, but a particularly powerful application of a model is its use as a system simulator. An emerging branch of computational systems biology strives to develop simulators for complex systems in biology and medicine, th…
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ABSTRACT Understanding of inter-system behavior develops biologically relevant intuition for drug repositioning as well as other biological research. But combining all the possible genes interactions into a system, and furthermore comparisons of multiple syste…
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2013-07-03T23:26:43Z
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2006-09-13T15:35:36Z
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2013-07-03T23:29:01Z
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Cancer systems biology integrates experimental models, data analysis, and dynamic network modeling to elucidate the complex mechanisms underlying cancer progression. This chapter outlines the essential requirements for experimental models, emphasizing the need…
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Oliver, Prof. Stephen George, (born 3 Nov. 1949), Professor of Systems Biology and Biochemistry, since 2007, and Director, Cambridge Systems Biology Centre, University of Cambridge; Fellow, Wolfson College, Cambridge, since 2009
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2017-11-30T16:44:16Z
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2013-08-28T08:51:51Z
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Abstract Ordinary differential equations (ODEs) provide a classical framework to model the dynamics of biological systems, given temporal experimental data. Qualitative analysis of the ODE model can lead to further biological insight and deeper understanding c…
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Margaret P. Chapman, Claire J. Tomlin
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2015-08-14T15:30:12Z
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2005-03-05T07:11:39Z
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Oliver, Prof. Stephen George, (born 3 Nov. 1949), Professor of Systems Biology and Biochemistry, since 2007, and Director, Cambridge Systems Biology Centre, University of Cambridge; Fellow, Wolfson College, Cambridge, since 2009
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2017-11-30T10:07:14Z
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2007-09-11T11:08:34Z
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The cover image is based on the Original Article Research on symptoms composition, time series evolution, and network visualisation of interstitial cystitis based on complex network community discovery algorithm by Lei Pang et al., https://doi.org/10.1049/syb2…
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Mounica C
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Photodynamic therapy (PDT) is a rapidly advancing treatment for multiple diseases. PDT involves the administration of a nontoxic drug or dye known as a photosensitizer (PS), either systemically, locally, or topically, to a patient bearing a lesion (frequently …
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2013-09-18T13:36:47Z
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This chapter introduces the special features that distinguish mammalian systems from other systems. It lists differences and similarities between bacteria, yeasts, and mammals in terms of features relevant to the design of synthetic biological devices and proj…
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Jamie A. Davies
2023-09-15T09:02:32Z
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