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• Implementation and acceleration of optimal control for systems biology
  Abstract Optimal control theory provides insight into complex resource allocation decisions. The forward-backward sweep method (FBSM) is an iterative technique commonly implemented to solve two-point boundary value problems (TPBVPs) arising from the applicatio…
  preprints Jesse A Sharp, Kevin Burrage, Matthew J Simpson 2021 置信度 0.74
• Synthetic Biology: A Systems Engineering Perspective
  crossref Domitilla Del Vecchio, Eduardo D. Sontag 2013-10-10T01:40:31Z 置信度 0.70
• The ERATO Systems Biology Workbench: An Integrated Environment for Multiscale and Multitheoretic Simulations in Systems Biology
  crossref Michael Hucka, Andrew Finney, Herbert Sauro, Hamid Bolouri 等 2018-12-14T02:28:05Z 置信度 0.70
• Editorial Board Page
  crossref 2024-12-02T20:38:11Z 置信度 0.70
• Editorial Board Page
  crossref 2021-05-24T19:16:00Z 置信度 0.70
• Signaling Flux Redistribution
  crossref Kumar Selvarajoo 2013-09-30T10:23:51Z 置信度 0.70
• Editorial Board Page
  crossref 2019-12-30T07:16:42Z 置信度 0.70
• Algorithmic Systems Biology — Computer Science Propels Systems Biology
  crossref Corrado Priami 2012-08-25T10:54:06Z 置信度 0.70
• Systems Biology Approach to Model the Life Cycle of <i>Trypanosoma cruzi</i>
  Abstract Due to recent advances in reprogramming cell phenotypes, many efforts have been dedicated to developing reverse engineering procedures for the identification of gene regulatory networks that emulate dynamical properties associated with the cell fates …
  crossref Alejandra Carrea, Luis Diambra 2015-08-26T01:02:18Z 置信度 0.70
• Editorial Board Page
  crossref 2023-06-02T01:36:31Z 置信度 0.70
• Editorial Board Page
  crossref 2026-03-23T22:05:47Z 置信度 0.70
• Editorial: Big data in systems biology.
  europepmc Holger Husi 2026 置信度 0.80
• Lactiplantibacillus plantarum: Systems Biology of a Versatile Microbe.
  Lactiplantibacillus plantarum is a metabolically versatile lactic acid bacterium found in fermented foods and the human gastrointestinal tract. Its relatively large genome (3.0-3.6 Mb) features an open pan-genome with 1,436-2,100 core genes and over 13,000 clo…
  europepmc 2026 置信度 0.80
• The principles of systems biology.
  europepmc 2026 置信度 0.80
• Systems biology in the era of AI: "winter" or "evolution"?
  europepmc 2026 置信度 0.80
• The Great Escape: the systems biology of endocrine resistance and lineage plasticity.
  europepmc 2026 置信度 0.80
• Systems biology during 20 years of PLoS Computational Biology.
  europepmc 2026 置信度 0.80
• Impaired taurine transport contributes to bronchopulmonary dysplasia: a systems biology analysis.
  europepmc 2026 置信度 0.80
• A systems biology approach to find representative genes in Acute Myeloid Leukemia.
  europepmc 2026 置信度 0.80
• INTOXICOM Workshop Report: Systems Biology Models for Toxicology
  europepmc 2026 置信度 0.80
• Pioneer: Dynamical Systems Biology for Spatiotemporal Omics Data.
  europepmc 2026 置信度 0.80
• Integrative quantum and systems biology of cancer: From molecular fluctuations to ecological outcomes.
  europepmc 2026 置信度 0.80
• Beyond static biomarkers: systems biology and AI for decoding cancer dynamics.
  europepmc 2026 置信度 0.80
• Weak form Scientific Machine Learning for Systems Biology: A Tutorial on WENDy
  europepmc 2026 置信度 0.80
• Agentic AI integrated with scientific knowledge: laboratory validation in systems biology.
  europepmc 2026 置信度 0.80
• Lipid dysregulation in chronic diseases: systems biology and omics perspectives.
  europepmc 2026 置信度 0.80
• Systems Biology of Aging, Metabolism, and Mitochondria.
  europepmc 2026 置信度 0.80
• Functional implications of SNPs in spliceosomal network: a structural systems biology approach.
  europepmc 2026 置信度 0.80
• Systems biology of yeast metabolism.
  europepmc 2026 置信度 0.80
• Reprogramming Plant Salt Tolerance: A Systems Biology Perspective on Algae-Derived Elicitors and Biostimulants.
  Soil salinisation poses a formidable threat to global agricultural productivity. It induces osmotic stress, ion toxicity and systemic oxidative damage in crops. Breeding salt-tolerant varieties is time-consuming. This creates an urgent need for rapid and susta…
  europepmc 2026 置信度 0.80
• SOORENA: A large-scale atlas of protein autoregulatory mechanisms for systems biology
  europepmc 2026 置信度 0.80
• Beyond phenylalanine to tyrosine: Mapping the comprehensive phenylalanine hydroxylase (PAH) pathway for systems biology.
  europepmc 2026 置信度 0.80
• The Macrophage Niche as a Primary Oncogenic Architect: A Two-Hit Systems Biology Hypothesis
  europepmc 2026 置信度 0.80
• The cell cloud: Adopting systems biology concepts in the era of single-cell immunology.
  europepmc 2026 置信度 0.80
• A computational systems biology view on the role of the menstrual cycle in endocrine health and disease.
  europepmc 2026 置信度 0.80
• The miRNA-virus axis in RNA virus infections: Mechanisms, therapeutic targeting, and systems biology approaches.
  europepmc 2026 置信度 0.80
• Integrating active inference with evolutionary systems biology: a framework for reconstructing music and language evolution
  europepmc 2026 置信度 0.80
• Systems Biology of the Microsatellite Signature in 156 Genomes of the Viral Family Rhabdoviridae.
  europepmc 2026 置信度 0.80
• Omics technologies in aquafeed: unlocking the black box towards systems biology.
  europepmc 2026 置信度 0.80
• Temporal network analysis in systems biology: concepts, inference, and validation.
  europepmc 2026 置信度 0.80
• Computational and multi-omics systems biology for precision microbiome therapeutics.
  The human gut microbiome represents a complex and dynamic therapeutic target whose effective interrogation requires system-level analytical approaches beyond single-omics or reductive methods. This mini-review synthesizes recent advances in computational model…
  europepmc 2026 置信度 0.80
• From traditional retting to precision bioprocessing: microbial ecology, enzymatic selectivity, and systems biology of jute retting.
  Jute is one of the world's most important lignocellulosic fibre crops, yet its commercial value remains highly dependent on retting, a biologically mediated fibre extraction process still largely governed by empirical practices and variable environmental condi…
  europepmc 2026 置信度 0.80
• The NeuroImmunoEndocrine Circuit of Umami Peptides: A Systems Biology Approach.
  europepmc 2026 置信度 0.80
• An integrated systems biology and machine learning framework for identifying potential biomarkers and pathways in autism spectrum disorder.
  europepmc 2026 置信度 0.80
• Challenges and potential applications of AI in systems biology.
  europepmc 2026 置信度 0.80
• Unveiling the transcriptomic landscape of coronavirus disease 2019 and psoriasis via systems biology-based analysis.
  europepmc 2026 置信度 0.80
• Bioinks in systems biology: integrating biomaterial design with cellular network modelling for predictive biofabrication.
  europepmc 2026 置信度 0.80
• Systems biology-based drug repurposing for neuroinflammation treatment in activated human microglia.
  europepmc 2026 置信度 0.80
• Data-driven system identification in cancer systems biology: A multiscale modeling approach to melanoma.
  Background and objective Developing systems biology models of cancer is critical for improving understanding of complex biological interactions and advancing appropriate therapeutic strategies. However, constructing complex, multiscale models that are easily p…
  europepmc 2026 置信度 0.80
• Pathway engineering for sustainable biomanufacturing: integrating AI, systems biology, enzyme engineering, and dynamic control.
  europepmc 2026 置信度 0.80
• Alzheimer's Disease as a Multi-Layer Network Disorder: A Systems Biology Framework Integrating Multi-Omics Mechanisms.
  europepmc 2026 置信度 0.80
• Microbiome-metabolite signaling networks in gastrointestinal disease: systems biology, network rewiring, and precision therapeutics.
  europepmc 2026 置信度 0.80
• Systems Biology Analysis of DLK1-DIO3 Imprinted microRNAs Cluster in Chronic Lymphocytic Leukemia
  europepmc 2026 置信度 0.80
• Future Prospects for Omics Sciences: Expanding the Boundaries of Systems Biology
  High-throughput omics technologies have transformed biology, enabling system-level exploration of genomes, transcriptomes, proteomes, metabolomes, and beyond. Despite progress, current omics approaches face limitations in temporal resolution, spatial context, …
  europepmc Mohamed Zarid 2026 置信度 0.80
• Multiscale Modeling and Systems Biology in Microgravity Investigations.
  europepmc 2026 置信度 0.80
• Determining parameter impact in systems biology models via sensitivity analysis: a comparative approach.
  europepmc 2026 置信度 0.80
• Systems biology of Alzheimer's Disease: a scoping review of key pathways and mechanisms.
  europepmc 2026 置信度 0.80
• Gut‑liver‑kidney axis: A systems biology framework for understanding and treating chronic kidney disease (Review).
  europepmc 2026 置信度 0.80
• Integrative systems biology identifies PSMB2 as a core oxidative stress-associated target in triple-negative breast cancer.
  europepmc 2026 置信度 0.80
• Cancer Stem Cells as Dynamic Attractor States: Systems Biology of Tumor Plasticity and Therapy Resistance.
  europepmc 2026 置信度 0.80
• The Need for a Systems Biology Approach in Cancer Explained.
  europepmc 2025 置信度 0.80
• Integrating AI, mechanistic modelling and network approaches in systems biology for translational research.
  europepmc 2026 置信度 0.80
• Curcumin and Its Protein Targets: Literature Review and Systems Biology Analysis.
  europepmc 2026 置信度 0.80
• AI-Augmented Multi-Omics for Abiotic Stress Responses: A New Frontier in Plant Hormone Systems Biology.
  europepmc 2026 置信度 0.80
• Integrative transcriptomic and systems biology analysis of public SLE datasets identifies immune regulatory pathways.
  europepmc 2026 置信度 0.80
• Rosacea through the lens of the exposome: From triggers to systems biology.
  europepmc 2026 置信度 0.80
• Integrated Pangenomic and Systems Biology Analyses Reveal the Genomic Basis of Virulence and Adaptation in <i>Bipolaris sorokiniana</i>
  europepmc 2026 置信度 0.80
• Systems biology integration of miR-mRNA profiles identifies steroid refractoriness mechanisms and biomarker candidates in ulcerative colitis.
  europepmc 2026 置信度 0.80
• Spatiotemporal Systems Biology Reveals Unique Cell-Type-Specific Carbon Metabolism Responses to Combined Abiotic Stresses in Poplar
  europepmc 2026 置信度 0.80
• A Roadmap for the Future of Systems Biology in Cancer Research.
  europepmc 2025 置信度 0.80
• Mechanistic Artificial Intelligence for Personalized Drug Therapy: Integrating Pharmacokinetics, Pharmacodynamics, Therapeutic Drug Monitoring, and Multiomic Systems Biology.
  europepmc 2026 置信度 0.80
• Systems Biology Approach to Gene Network Analysis Identifies Therapeutic and Diagnostic Targets in Colorectal Cancer
  europepmc 2026 置信度 0.80
• BioPhasor: Decoding Cellular State Tensors from Multi-Omics Phasor Dynamics for Quantum Ready Systems Biology
  europepmc 2026 置信度 0.80
• Beyond Weight: Systems Biology and Precision Medicine Redefine Obesity as a Multidimensional Disease.
  europepmc 2026 置信度 0.80
• Editorial: Advances in systems biology and bioinformatics for microbiology research.
  europepmc 2026 置信度 0.80
• Integrative systems biology analysis reveals diagnostic and prognostic DNA methylation signatures in esophageal cancer.
  europepmc 2026 置信度 0.80
• Systems biology approaches to unravelling neonatal sepsis and potential for precision diagnostics and therapeutics.
  europepmc 2026 置信度 0.80
• Immune-Metabolic Interactions in the Degenerative Retina: A Systems Biology Approach Based on Diabetic Retinopathy.
  europepmc 2026 置信度 0.80
• p53 Orchestrates the Immunogenic-Tolerogenic Pyroptosis Switch in Non-Small Cell Lung Cancer: A Systems Biology Approach.
  europepmc 2026 置信度 0.80
• Large-Scale Data Analysis of Post-Traumatic Stress Disorder (PTSD) Through GWAS Fine-Mapping and Systems Biology.
  europepmc 2026 置信度 0.80
• From edits to insights: precision microbial engineering for systems biology.
  europepmc 2026 置信度 0.80
• Systems Biology and Multi-Omics in Asthma and COPD: A Systematic Review of Computational Approaches (2010-2024).
  europepmc 2026 置信度 0.80
• Predictive Algal Systems Biology: Integrating Omics, Genome-Scale Metabolic Models, and Machine Learning.
  Algae represent one of the most metabolically diverse and ecologically significant groups of photosynthetic organisms, contributing fundamentally to global biogeochemical cycles while offering major potential for biotechnology applications such as biofuels, nu…
  europepmc 2026 置信度 0.80
• NSAIDs trigger drug-specific response to exercise: a multi-omics systems biology analysis of a randomized crossover trial.
  europepmc 2026 置信度 0.80
• Systems Biology of Metabolic Dysregulation in Ankylosing Spondylitis Using scRNA-Seq Data.
  europepmc 2026 置信度 0.80
• Rethinking medical education through systems biology to address complexity.
  europepmc 2026 置信度 0.80
• Interpretable machine learning meets systems biology to decode genotype-phenotype maps
  europepmc 2026 置信度 0.80
• Systems biology of Wnt signaling in glioma chemotherapy resistance: Integrating multi-omics mechanisms and emerging therapeutic vulnerabilities (Review).
  europepmc 2026 置信度 0.80
• Rediscovering the Gut-Mito-Ear Axis: A Systems-Biology Framework for Ototoxic Vulnerability and Microbiome-Targeted Prevention.
  europepmc 2026 置信度 0.80
• Mapping a therapeutic redox ceRNA network in alcohol use disorder: Systems biology insights for drug repurposing.
  europepmc 2026 置信度 0.80
• Roadmap for a Systems Biology Initiative in Iran.
  europepmc 2025 置信度 0.80
• Publisher Correction: Rethinking medical education through systems biology to address complexity.
  europepmc 2026 置信度 0.80
• Spatial determinants of CAR-T and cellular-therapy response in diffuse glioma: a scoping review
  Scoping review protocol (JBI methodology; PRISMA-ScR reporting). Registered before screening/charting. Guarantor: Alexandru C. Stan, ORCID 0000-0002-7463-0393, independent researcher.
  datacite Alexandru-Constantin Stan 2026 置信度 0.66 Immunology and Infectious DiseaseTranslational Medical ResearchLaboratory and Basic Science Research Life SciencesBioinformaticsOther Life Sciences
• Psychotropic medication use, prescription practices, and determinants among university students: a scoping review
  College students undergo a period of rapid psychological development in which the social environment plays a critical role in shaping their future as individuals within society. The university setting imposes heightened demands regarding academic commitment, r…
  datacite Marco Tulio Ayala Avila, Carlos Said Páez-Márquez 2026 置信度 0.66 Medical SciencesClinical EpidemiologyPublic HealthMedicine and Health SciencesMedical Pharmacology
• Translational Gaps of Molecular Detection and Food Integrity Systems in Halal Authentication Technologies: A Scoping Review
  This project contains the protocol and supporting materials for a scoping review examining molecular detection and food integrity technologies applied to halal authentication. The review aims to characterize the landscape of molecular and emerging detection te…
  datacite Vritta Amroini Wahyudi 2026 置信度 0.66 Life SciencesBiotechnologyFood SciencePRISMAPRISMA-ScR
• Eye Tracking como ferramenta de apoio ao diagnóstico de crianças com Perturbação do Espectro do Autismo (PEA): uma revisão sistemática
  Revisão sistemática da literatura sobre a utilização da ferramenta Eye Tracking como recurso de apoio ao diagnóstico de crianças com Perturbação do Espectro do Autismo (PEA).
  datacite Leila Matheus Medeiros, Victor Hugo da Silva 2026 置信度 0.66 Cognitive NeuroscienceLife SciencesNeuroscience and NeurobiologyAutism Spectrum DisorderChild
• Mapping Responsiveness and Other Psychometric Properties of Oral Health-Related Quality of Life Instruments in Periodontal Intervention Studies: A Scoping Review
  Oral health-related quality of life (OHRQoL) has become a key patient-reported outcome in periodontal research. Although several OHRQoL instruments have been applied in periodontal intervention studies, it remains unclear how their responsiveness and other psy…
  datacite Josy Lorena Peres da Silva Vilarinho, Jordana Vasconcelos Nobre, ANA JULIA MARTINS TARGINO, Karina Schittine B. Lomba 等 2027 置信度 0.66 Medicine and Health Sciencesperiodontitis; oral health-related quality of life; patient-reported outcome measures; responsiveness; psychometric properties; scoping review.
• Biological and experimental determinants of cytogenetic stability during induced chromosome manipulation in plants: a systematic review
  This systematic review critically analyzes protocols for chromosome doubling in plants using antitubulin agents (colchicine, oryzalin, trifluralin) for doubled haploid (DH) production and polyploidy induction. It evaluates how tissue organization, agent type, …
  datacite FRANCISCO REMIGIO CANO MACIAS, Wellington Ronildo Clarindo, Milene Miranda Praça Fontes, João Paulo de Morais Oliveira 等 2026 置信度 0.66 Plant SciencesAgricultureHorticultureLife SciencesBiotechnology
• FORMULATION AND EVALUATION OF NANOGEL BASED ANTIFUNGAL DRUG DELIVERY SYSTEMS
  Fungal infections represent a major public health concern worldwide, affecting millions of individuals annually. These infections range from mild superficial skin conditions such as dermatophytosis and candidiasis to severe systemic diseases that may lead to l…
  datacite Mahesh Kale, Aijaz A. Sheikh, Suraj A. Sagrule, Kailash R. Biyani 2026 置信度 0.66 Fungal infectionsNanogelsAntifungal drug deliveryControlled release
• FORMULATION AND EVALUATION OF NANOGEL BASED ANTIFUNGAL DRUG DELIVERY SYSTEMS
  Fungal infections represent a major public health concern worldwide, affecting millions of individuals annually. These infections range from mild superficial skin conditions such as dermatophytosis and candidiasis to severe systemic diseases that may lead to l…
  datacite Mahesh Kale, Aijaz A. Sheikh, Suraj A. Sagrule, Kailash R. Biyani 2026 置信度 0.66 Fungal infectionsNanogelsAntifungal drug deliveryControlled release