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• Individualized cortical gradient and network topology reveal symptom-linked disruptions and neurobiological subtypes in schizophrenia
  Schizophrenia is often conceptualized as a brain network disorder, yet the organizational principles and heterogeneity underlying widespread cortical abnormalities remain poorly understood. Leveraging multisite MRI data from 3,958 individuals diagnosed with sc…
  preprints 2026 置信度 0.74
• MORPHIS (MORPHological Interpretable Signature) captures heterogeneous treatment- and aging-related responses of single cells
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• Polli-markers: spectral and chemical biomarkers for detecting cryptic early plant pollination responses
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• Drug allergy labels and complications after surgery: a prospective multi-centre cohort study
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• Survival curve steepening and flattening reflect evolutionarily conserved changes in the variability of aging
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• Small molecule bioactivity benchmarks are often well-predicted by counting cells
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• Determining the return on investment of a global adaptive platform trial for critically ill patients during COVID-19: A value of implementation analysis in low- and middle-income countries and globally
  Abstract Introduction: Adaptive platform trials rapidly generate robust evidence, essential for resource-limited health systems like those in low- and middle-income countries (LMICs). We analyzed the return on investment of an adaptive platform trial using Val…
  preprints 2026 置信度 0.74
• An ancestry-enriched PIEZO1 missense variant biases HbA1c-based diagnosis of prediabetes and type 2 diabetes in South Asians
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• Efficacy of Distress Tolerance Techniques of Dialectical Behavior Therapy in Persons with Obsessive-Compulsive Disorder: a study protocol for a randomized controlled trial
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• A canary in the mind: A single baseline brain scan predicts adolescent depression and anxiety one year later
  Mood and anxiety disorders emerge predominantly in adolescence, yet they are usually identified only once symptoms have consolidated, when intervention can only be reactive. A marker that registers the loss of healthy brain function before symptoms crystallise…
  preprints 2026 置信度 0.74
• Women’s intentions and motivations towards health behaviour change before pregnancy: a cross-sectional survey of pregnant women in Australia
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• The potential health and economic impact of introducing the vaccine candidate VPM1002 to prevent tuberculosis disease in low- and middle-income countries: a modelling study
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• Clinical outcomes and mortality risk among inborn and referred newborns admitted to hospitals in Kenya
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• Ultrasound-targeted microbubble destruction combined with chemoimmunotherapy in locally advanced MSS/pMMR rectal cancer (UNIC): an exploratory phase 2 study
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• Approaches to sharing trial results with adult patients and the public: a qualitative interview and focus group study
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• A qualitative study to explore how to increase participation of South Asian women in gestational diabetes clinical trials
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• Using opioid analgesia for chronic pain in adults aged 85+: a qualitative study
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• Influence of comorbid diabetes mellitus on outcomes in multiple sclerosis: an English population-based matched cohort study
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• Post-pandemic mortality patterns and COVID-19 burden considering multiple death causes
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• Ethnic and sex inequalities in premature coronary artery disease across disaggregated South Asian and Black subgroups in England: a population-based cohort study
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• OUTSIDE 2: Outdoor swimming as a nature-based intervention, offered in addition to usual care, compared to usual care alone, in people with depression: A study protocol for a randomised controlled trial and economic evaluation
  preprints 2026 置信度 0.74
• Healthcare professionals’ perspectives on a multilevel cardiovascular risk management intervention (PROSPERA programme)
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• Adaptations and interpretation of Intelligence Tests for Adults with Visual Impairment: A Literature Review and Interviews with Healthcare Professionals
  Background Administering and interpreting intelligence tests for adults with visual impairment (VI) presents practical and methodological challenges, because standard test batteries rely heavily on visual tasks and lack specific norm-groups tailored to this po…
  preprints 2026 置信度 0.74
• A service evaluation of restraint, seclusion and escalation in inpatient mental health care: a retrospective observational study in England
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• Effectiveness of analgesic ear drops as add-on treatment to usual care in children with acute otitis media: the OPTIMA pragmatic randomised controlled trial
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• Acceptability, Appropriateness and Feasibility of PROM and PREM Use in Swiss General Internal Medicine Divisions: A descriptive, sequential mixed method study
  ABSTRACT Background Patient-reported outcome measures (PROMs) and patient-reported experience measures (PREMs) are increasingly used to integrate patient perspectives into healthcare delivery, yet their routine implementation in general internal medicine (GIM)…
  preprints 2026 置信度 0.74
• Optimal Clinical Trials Platform for Progressive Multiple Sclerosis (OCTOPUS): protocol for an international, multi-arm, multi-stage, platform, randomized controlled, double-blind, phase 3 clinical trial
  ABSTRACT Introduction Current treatments for multiple sclerosis (MS) do not address the pathological processes of neurodegeneration and chronic demyelination. This, coupled with the significant challenges of translating promising phase 2 results to phase 3 tri…
  preprints 2026 置信度 0.74
• Complex non-falciparum transmission and widespread insecticide resistance in Penka-Michel, a hyperendemic malaria focus of the Cameroon highlands
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• The impact of an outbreak event of the Siberian larch casebearer moth Protocryptis sibiricella on the radial growth of Siberian larch
  preprints 2026 置信度 0.74
• <i>PALM3</i> and hearing loss: a potential dual diagnosis interfering with novel gene discovery
  ABSTRACT Hereditary hearing loss is highly genetically heterogeneous, with emerging overlap between genes implicated in early-onset and age-related hearing loss. We report a consanguineous family with autosomal recessive, non-syndromic hearing loss in which th…
  preprints 2026 置信度 0.74
• Identifying community nurses’ contributions to end-of-life care: an online survey study
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• Cost-Effectiveness of the IMPALA Monitoring System for Hospitalised Children in Low-Resource Settings: A Pragmatic Before-and-After Study
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• Muscle Ageing and Sarcopenia Study (MASS) Lifecourse: a unique resource for understanding skeletal muscle ageing across adulthood
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• Balancing Lucidity: Muscle and Vestibular Stimulation for Lucid Dream Induction
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• Consensus Recommendations for the Clinical Management of Wolfram syndrome Using a Delphi Method
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• Nationwide estimates of SARS-CoV-2 infection fatality rates and numbers needed to vaccinate for SARS-CoV-2 vaccines in 2024 in Austria
  preprints 2025 置信度 0.74
• Online extinction and novelty-triggered recovery of life-long visual memories in navigating ants
  preprints 2026 置信度 0.74
• Complex harmonic manifolds in mindfulness-based cognitive therapy for major depressive disorder
  Major depressive disorder (MDD) is a heterogeneous mental disorder characterised by rumination. Mindfulness-based cognitive therapy (MBCT) is an evidence-based treatment developed to target rumination and recurrence risk. Ongoing studies have begun to identify…
  preprints 2026 置信度 0.74
• Dancing on Linnaeus’ Palm: Divergence of Species Scapes between ecologists and taxonomists
  preprints 2025 置信度 0.74
• Association of early life adversity with internalizing and externalizing behavior across 3 low- and middle-income countries
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• Relationships between increasing pre-load meal size, post-prandial acyl ghrelin, LEAP2, insulin, glucose, appetite, and food intake in adults without obesity
  ABSTRACT The satiety cascade includes post-prandial increases in plasma glucose and insulin, and changes in appetitive gut hormones, including decreases in orexigenic stomach-derived ghrelin, and increases in liver-foregut-derived LEAP2 hormone, a ghrelin anta…
  preprints 2026 置信度 0.74
• Expectations and attitudes in primary care towards home-based testing for diagnosing asthma: a mixed methods study
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• The association between severity and aetiology of chronic liver disease and seasonal influenza vaccination uptake in adults: a retrospective cohort study using English primary care data (2019–2024)
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• Novel repressors of cambium activity in <i>Arabidopsis</i>
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• Wellbeing While Waiting: Effectiveness and implementation of youth social prescribing for young people awaiting CAMHS support
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• The Relationship between Health-Related Procrastination, Personality Type, and Quality of Life in Nurses
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• The population structure and genetic health of European wolves
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• Trends in student perceptions of school connectedness from 2001 to 2024: Context before and immediately after the implementation of the Whole School Approach to emotional and mental wellbeing in Wales
  Abstract Background School connectedness is an important protective factor for young people’s mental health, however, there is an absence of analyses exploring how it has changed over time in primary and secondary schools. This is considered here in the contex…
  preprints 2026 置信度 0.74
• Engineering quantitative root disease resistance in barley by targeting conserved SCAR susceptibility genes without compromising seed yield or mycorrhizal symbiosis
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• Material requirements for adapting to climate change in the Maldives
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• JARVIS, should this study be selected for full-text screening? Performance of a Joint AI-ReViewer Interactive Screening tool for systematic reviews
  Background Systematic reviews are essential for evidence-based decision making in health sciences but require substantial time and resource for manual processes, particularly title and abstract screening. Recent advances in machine learning and large language …
  preprints 2026 置信度 0.74
• Live high-content imaging with automated analysis reveals mitochondrial changes during vascular calcification
  Mitochondrial dysfunction is implicated in a wide range of disorders, including cancer, neurodegeneration, and cardiovascular diseases. Conventional assays typically assess mitochondrial function by measuring bulk respiration rates across thousands of cells. W…
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• Optimal cues for transmission investment in malaria parasites
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• Linking transmission dynamics and economic evaluation to assess schistosomiasis programme strategies across districts in Malawi
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• Distress above diagnostic constraints: transdiagnostic psychological and somatic symptom patterns in young adults
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• Clinical trials in Lusophone Africa – results from a capacity building training initiative
  preprints 2025 置信度 0.74
• Associations of autism diagnosis, traits, and genetic liability with subsequent night-time sleep duration trajectories from infancy to adolescence
  preprints 2026 置信度 0.74
• Validation of the instrument Life Conditions Scale (LifeCon Scale) in university students of health sciences degrees in Spain
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• Breast cancer is linked to changes in the urinary extracellular vesicle proteome
  preprints 2026 置信度 0.74
• Longitudinal associations between adverse childhood experiences with moderate-risk to problem gambling in young adulthood: A prospective UK cohort study
  Previous research links Adverse Childhood Experiences (ACEs) with problem gambling, but most studies rely on retrospective reporting and focus narrowly on maltreatment, overlooking adversities such as parental mental health issues. Using data on 3794 young adu…
  preprints 2026 置信度 0.74
• Experiences of delivering social homecare at end-of life: insights from a qualitative study drawing on multiple perspectives
  preprints 2025 置信度 0.74
• Evolutionary rewiring of host metabolism and interferon signalling by SARS-CoV-2 variants
  Summary SARS-CoV-2 variants differ in transmissibility and immune evasion, but their effects on host-cell metabolism and signalling remain less defined. Using integrated transcriptomic, phosphoproteomic, and amino acid profiling in primary nasal epithelial cel…
  preprints 2025 置信度 0.74
• Dissociable contributions of cortical thickness and surface area to cognitive ageing: evidence from multiple longitudinal cohorts
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• Transdisciplinary Epidemiology in Schools: Integrating Molecular Environmental and Social Surveillance Through Community Science
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• Integrating Functional Transdiagnostic Dimensions of Psychopathology with Cortical Organization
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• Good Governance in Primary Health Care Centers: Real-life evidence from Iran
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• Pathways to Breast Cancer Care and Delays in Diagnosis and Treatment in sub- Saharan Africa: A Systematic Review and Meta-Analysis
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• Characterizing individuals fulfilling clinical criteria for LATE in a tertiary memory clinic
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• Molecular determinants underlying substrate receptor specificity of human CRL4B E3 ubiquitin ligase
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• VadK, a Non-Canonical Kinase that Regulates the Methylcitrate Cycle and is Essential for <i>Mycobacterium tuberculosis</i> Virulence
  preprints 2025 置信度 0.74
• Mapping Digital and Assistive Technologies for Dementia and Related Neurodegenerative Conditions: A Scoping Review
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• Assessing Fertility-Related Quality of Life and Psychological Well-being among infertile women
  preprints 2025 置信度 0.74
• NLR immune receptors can exhibit tissue-specific expression patterns across legume species
  ABSTRACT Pathogen pressure threatens legume crop productivity worldwide. Nucleotide-binding leucine-rich repeat (NLR) immune receptors serve as crucial plant resistance genes, recognizing pathogens and triggering immunity. However, the extent and patterns of N…
  preprints 2026 置信度 0.74
• Long term use and replacement of near vision glasses for presbyopia, in Punjab, Pakistan: a cross-sectional survey
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• Scaling nature-based programmes for adolescent mental health and wellbeing: Evidence- informed policy and research directions from England
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• ‘I’m fighting my case all the time’. Candidacy, stigma, and negotiated access in cancer care: experiences of adults with intellectual disability and their supporters
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• Protective effect of prior knowledge in ageing
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• Longitudinal Investigation of Social Isolation, Loneliness, and Health Outcomes Among Refugees in a Low-Resource Setting
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• Optimising the prevention, detection and management of diabetes distress in adults with type 1 diabetes: Feasibility study protocol (D-stress feasibility study)
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• AncientMetagenomeDir dating metadataset highlights need for standardised radiocarbon reporting in ancient DNA
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• Age-structured modelling of Ebola convalescence and re-emergence risk: a Bayesian approach
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• Virtual Reality applied to Post-Stroke Rehabilitation: design and development of the NeuroRehab VR Software
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• The Role of Poverty-Related Social Determinants in Maternal and Perinatal Health Inequities: A cross-sectional study using the eLIXIR Born in South London, UK maternity-child data linkage
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• Growth mindset and grit as psychological resources in later life: Age, socioeconomic, and health patterning in the English Longitudinal Study of Ageing
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• Tracking cross-border transmission of Rwanda’s successful dominant rifampicin-resistant Mycobacterium tuberculosis clone using genomic markers
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• AmpliPhy improves gene trees by adding homologous sequences without affecting alignments
  ABSTRACT In phylogenomics, gene tree reconstruction depends on multiple sequence alignment (MSA) and tree inference, and ongoing work continues to improve inference quality. Denser taxon sampling has been associated with improved gene tree inference, suggestin…
  preprints 2026 置信度 0.74
• HOW COMMUNITY PHARMACIES CAN RAISE UTERINE CANCER AWARENESS AMONG WOMEN FROM ETHNIC MINORITY POPULATIONS
  ABSTRACT Background Community pharmacies are a potential route to reach underserved groups due to their locations and staff, who often reflect the diversity of the populations they serve. This study aimed to explore the potential for a uterine cancer awareness…
  preprints 2026 置信度 0.74
• drFrankenstein: An Automated Pipeline for the Parameterisation of Non-Canonical Amino Acids
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• Affected others’ perspectives on the burden, drivers, and prevention of gambling- related harms: a qualitative study
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• Multisectoral Framework for Responding to the Needs of Children with Neurodevelopmental Disabilities and their Families in Ethiopia: A Review with Implications for Policy
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