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• HIRA-SETDB1-H3K9me3 axis regulates chromatin architecture in leukemia cells.
  Histone cell cycle regulator A (HIRA) confers chromatin accessibility and regulates developmental hematopoiesis. Previously, we showed that HIRA expression is higher in patient samples from chronic myeloid leukemia (CML) compared to samples from healthy indivi…
  pubmed Shirude MB, Devarajan A, Sahu SA, Mukherjee A 等 2026 Jun 置信度 0.82
• [Clinical practice guideline for integrated PET/MRI in Parkinson's disease (2026 edition)].
  To advance the precise diagnosis and treatment of Parkinson's disease (PD) and related movement disorders, standardize the clinical application of integrated PET/MRI, enhance diagnostic efficacy, and optimize patient management, the Clinical Practice Guideline…
  pubmed Chinese Society of Medical Imaging Technology, Chinese Society of Radiology, Chinese Society of Nuclear Medicine, Beijing Society of Nuclear Medicine 等 2026 Apr 28 置信度 0.82
• Inhibition effect of natural deep eutectic solvents on frozen egg yolk gelation: Rheological properties, protein structure, and hydrogen bond networks.
  Egg yolk undergoes a pronounced increase in viscosity after freezing, which commonly referred to as ice-induced gelation. Therefore, a natural deep eutectic solvent (NADES) composed of xylose and choline chloride was developed. Result showed that NADES reduced…
  pubmed Ma Y, Zhao W, Xu Y, Liu Y 等 2026 Jul 1 置信度 0.82
• Mitochondrial fusion heterogeneity drives bidirectional tumor phenotypic transition in combined hepatocellular-cholangiocarcinoma.
  Dysregulation of mitochondrial dynamics modulates malignant cell fate; however, the substantial heterogeneity in mitochondrial dynamics among tumor cells within individual tumor nodules and the resultant functional consequences remain inadequately characterize…
  pubmed Chen L, Wang D, Qin W, Wang G 等 2026 置信度 0.82
• Systemic Drivers and Molecular Mechanisms of Sarcopenia in Aetiology-Specific End-Stage Liver Disease.
  Patients with end-stage liver disease (ESLD) often present with sarcopenia, defined as loss of skeletal muscle mass and quality, which is associated with reduced quality of life and increased mortality. However, the molecular mechanisms driving sarcopenia in E…
  pubmed Nicholson T, Allen SL, Quinlan JI, Dhaliwal A 等 2026 Jun 置信度 0.82
• Grayscale ultrasound radiomics for characterizing subpleural pulmonary lesions: a multicenter prospective study.
  To develop and validate a radiomics model based on grayscale ultrasound (GSUS) images for characterizing subpleural pulmonary lesions (SPLs).
  pubmed Yi J, Zhao X, Bi K, Wu K 等 2026 Apr 25 置信度 0.82
• Observation of QED Effects, Breit Interaction, and Electron Correlation in Highly Charged Au Ions Produced by a High-Power Laser.
  We report on measurements of extreme ultraviolet (EUV) radiation from highly charged gold ions in laser-produced plasma to investigate the quantum electrodynamics (QED) effects, Breit interaction, and electron correlation (EC) effects which play a crucial role…
  pubmed Ma B, Ren J, Wang S, Zhang S 等 2026 Apr 10 置信度 0.82
• PSMA PET/MRI-US Fusion-Guided Irreversible Electroporation for Focal Therapy of Prostate Cancer.
  Here, we present a precision oncologic approach for localized prostate cancer (PCa) in a 66-year-old man. Overcoming the limitations of conventional MRI in delineating tumor extent and multifocality, preoperative 68 Ga-PSMA PET/MRI precisely defined the index …
  pubmed Xia QD, Xu MY, Zhu XH, Yang J 等 2026 置信度 0.82
• SAM2HIPT: a hybrid deep learning framework integrating SAM2 and HIPT with joint loss optimization for immunohistochemical cell nucleus segmentation.
  Nucleus segmentation in immunohistochemistry images plays a critical role in cancer diagnosis and treatment assessment. However, existing methods remain limited in segmentation accuracy and boundary delineation due to staining heterogeneity, densely packed cel…
  pubmed Yao Y, Li S, Hu Y, Xue Y 等 2026 May 5 置信度 0.82
• Systematic discovery of pro- and anti-HIV host factors in primary human CD4+ T cells.
  Host factors that promote or restrict human immunodeficiency virus (HIV) infection in human CD4+ T cells have not been comprehensively identified. We employed orthogonal genome-wide CRISPR activation (CRISPRa) and CRISPR knockout screens in primary CD4+ T cell…
  pubmed Rathore U, Dugan E, Thornton H, Kumar VE 等 2026 Jun 11 置信度 0.82
• Laser powder bed fusion of NiTi: effect of laser power and scanning speed on phase transformation temperatures.
  Despite the growing use of powder bed fusion laser beam in metals (PBF-LB/M) to fabricate NiTi shape memory alloys, the interplay between process parameters and functional performance remains poorly understood, hindered by small-scale studies that fail to capt…
  pubmed Cebrián Carcavilla A, Zaki W 2026 Apr 19 置信度 0.82
• Unexpected Cervical Lymph Node Metastasis Revealing TFE3-Rearranged Renal Cell Carcinoma: Intraoperative Cytologic Clues to an Occult Renal Primary.
  TFE3-rearranged renal cell carcinoma (TFE3-rRCC) is a rare subtype of renal carcinoma that may present diagnostic challenges in cytologic specimens, particularly when metastatic disease represents the initial clinical manifestation. We report the case of a 72-…
  pubmed Pusztaszeri MP 2026 Jul 置信度 0.82
• A comparative study of industrial and open-source SCADAs to optimize the design of control systems for the IFMIF-DONES plant.
  This study aims to provide a technological comparison of possible alternatives for supervision and control system implementations to support the design of the IFMIF-DONES (International Fusion Materials Irradiation Facility DEMO Oriented Neutron Source) plant …
  pubmed Cruz-Miranda J, Damas M, Valenzuela E, Cappelli M 等 2026 Apr 17 置信度 0.82
• Low-grade neuroepithelial tumor with FGFR1::TACC1 fusion: a clinicopathologic analysis of seven cases.
  PURPOSE: To characterize the clinicopathologic, radiologic, immunophenotypic, and molecular features of low-grade neuroepithelial tumor harboring FGFR1::TACC1 fusion. METHODS: Seven cases with confirmed FGFR1::TACC1 fusion were retrospectively analyzed. Clinic…
  pubmed Yang M, Zhou D, Fan J, Qi X 等 2026 置信度 0.82
• A Rare Case of Solitary Brain Metastasis From Papillary Thyroid Carcinoma: The Role of Empiric I-131 Therapy and SPECT/CT (Single Photon Emission Computed Tomography/Computed Tomography) in Achieving an 11-Year Survival.
  Brain metastases from papillary thyroid carcinoma (PTC) are rare and typically associated with a poor prognosis; however, early detection of solitary lesions can lead to exceptional long-term outcomes. We present the case of a 65-year-old man with a history of…
  pubmed Vatankulu B, Yilmaz S 2026 置信度 0.82
• The Role of 18F-Fluorodeoxyglucose (18F-FDG) Positron Emission Tomography/Computed Tomography (PET/CT) Values in the Detection of Bladder Carcinoma.
  Background and objective 18F-fluorodeoxyglucose (FDG) is physiologically excreted into urine, which can obscure intravesical lesions and complicate the detection of bladder cancer on FDG positron emission tomography-computed tomography (PET/CT). This study aim…
  pubmed Yoshida R, Yoshizako T, Tanaka S, Okamura K 等 2026 Mar 置信度 0.82
• Cross-Tissue Transcriptome-Wide Association Study and TWAS-FOCUS Fine-Mapping Reveal Novel Susceptibility Genes for Primary Open-Angle Glaucoma.
  Primary open-angle glaucoma (POAG) is a common eye disorder that can lead to irreversible vision loss. Although genome-wide association studies (GWAS) have identified several genetic loci associated with POAG risk, the specific causative genes and mechanisms r…
  pubmed Pan Z, Liu K, Jiang B, Dong C 2026 Apr 6 置信度 0.82
• Intelligent diagnosis of ovarian cancer in PET/CT imaging based on KiteNet-MobileNetv3 fusion and CarveMix augmentation.
  Ovarian cancer refers to a malignant tumor that grows in the ovary, which has the highest mortality rate of gynecological cancers. Positron emission tomography and computer tomography (PET/CT) imaging is widely used for the localization and characterization of…
  pubmed Li J, Hu K, Fan X, Wang S 等 2026 Apr 14 置信度 0.82
• The ATRXt Protein Represses rDNA Transcription While Mirroring ATRX Interactions and Heterochromatin Localization.
  The ATRX gene encodes an SWI/SNF-type chromatin remodeling protein that is critical for proper development of the mammalian central nervous system and musculoskeletal system. While significant progress has been made in understanding the molecular functions of …
  pubmed Levesque MG, Picketts DJ 2026 Mar 29 置信度 0.82
• Design of a Molten Salt Flow Cell for Combined Absorbance and Laser-Induced Breakdown Spectroscopy for Online Measurements.
  A novel flow cell allowing for multiple optical spectroscopy measurements on flowing molten salts was designed, and demonstrative calibrations of impurities in aqueous samples were performed. Online compositional measurements of molten salts are of high intere…
  pubmed Andrews HB, Kitzhaber ZB, Orea D, Sadergaski LR 等 2026 May 置信度 0.82
• New PPARG Exons: Cell-Specific Expression of Their RNAs in the Human Placenta.
  Peroxisome proliferator-activated receptor γ (PPARγ), encoded by the PPARG gene on chromosome 3p25.2 in humans, is a ligand-dependent transcription factor that belongs to the nuclear receptor family. In various tissues, PPARγ controls cell di…
  pubmed Vignaud ML, Morin N, Fournier T 2026 Apr 1 置信度 0.82
• Intrauterine exposure to glyphosate-based herbicide during pregnancy induces testicular impairment via activating ferroptosis in offspring.
  Glyphosate-based herbicide (GBH) is a broad-spectrum herbicide extensively used in agriculture, which poses increased residual risks in grains and food products, thereby endangering human health. However, the impact of maternal GBH exposure on fetal testicular…
  pubmed Bai G, Wang R, Tong Y, Bai Y 等 2026 May 置信度 0.82
• Clinicopathological and molecular characterisation of superficial CD34-positive fibroblastic tumour: A systematic review.
  This systematic review aims to comprehensively evaluate the clinicopathological and molecular features of superficial CD34-positive fibroblastic tumour (SCD34FT), a recently described intermediate-grade soft-tissue neoplasm recognised in the 5th edition of the…
  pubmed Das S, Perret R, Khan AA, Mishra P 等 2026 May 18 置信度 0.82
• Avapritinib for targeting KIT D816V-mutated acute myeloid leukemia relapsed after allogeneic hematopoietic stem cell transplant with extramedullary and central nervous system involvement.
  Relapse of acute myeloid leukemia with CBFB::MYH11 fusion and KIT D816V mutation after allogeneic hematopoietic stem cell transplantation is uncommon and often associated with aggressive extramedullary spread and poor outcomes, particularly when the central ne…
  pubmed Frigeni M, Algarotti A, Salmoiraghi S, Belotti C 等 2026 Apr 10 置信度 0.82
• Structure and composition of supported lipid bilayers: a comparison between solvent-assisted lipid bilayer and vesicle fusion methods.
  Supported lipid bilayers (SLBs) are crucial model membrane platforms to study the structure and dynamics of cellular membranes. Vesicle fusion (VF) is one of the most widely used approaches to forming SLBs, though it suffers from compositional limitations and …
  pubmed Felderer B, Buchanan C, Wang S, Shen HH 等 2026 Apr 1 置信度 0.82
• Combined Menin and XPO1 inhibition drive synergistic antileukemic activity in KMT2Ar and NPM1-m AML.
  Menin scaffolds the oncogenic histone-lysine-N-methyltransferase (KMT2A)-fusion protein (FP) complex in KMT2A- r and wild-type KMT2A complex in NPM1 -m acute myeloid leukemia (AML). Menin inhibitors (MIs) are effective in KMT2A -r AML and NPM1 -m AML. However,…
  pubmed Uddin MH, Dhiman S, Han Y, Aboukameel A 等 2026 Mar 13 置信度 0.82
• Leveraging MrkA Display on Self-Assembling Protein Nanoparticles for Enhanced Immune Activation.
  Self-assembling protein nanoparticles (NPs) offer a versatile platform to enhance antigen immunogenicity through a multivalent display. Klebsiella pneumoniae (Kp) is a critical multidrug-resistant pathogen for which no licensed vaccine exists, posing a signifi…
  pubmed Monaci V, Oldrini D, Giusti F, Cappelli L 等 2026 Apr 22 置信度 0.82
• VB-84922 is a small molecule that inhibits ER-to-golgi transport of SREBPs-SCAP complexes.
  The sterol response element binding proteins (SREBPs), SREBP-1a/c and SREBP-2, are sterol-regulated transcription factors that control the expression of cholesterol and fatty acid-raising genes. Elevated expression of SREBPs has been linked to increased morbid…
  pubmed Corbalan JJ, Schormann W, Jagadeesan P, Kale J 等 2026 置信度 0.82
• Comprehensive molecular analyses for diagnosis and treatment guidance in an adult neuroblastoma patient.
  Metastatic cancers of unknown primary (CUP) pose significant diagnostic and therapeutic challenges. We present the case of a 63-year old male patient with a CUP showing neuroendocrine differentiation, metastasized to the iliac bone, bone marrow, supraclavicula…
  pubmed Rieke DT, Schwartz S, Ochsenreither S, Chapuy B 等 2026 Apr 10 置信度 0.82
• STAG2 loss amplifies EWS-FLI1-driven microsatellite enhancer activity promoting Ewing sarcoma aggressiveness.
  Ewing sarcoma is driven by chromosomal translocations that fuse a FET RNA-binding protein to an ETS transcription factor, most commonly generating the EWS-FLI1 fusion oncoprotein. EWS-FLI1 engages GGAA microsatellite repeats to form de novo enhancers that acti…
  pubmed Eyunni S, Chu SC, Guan ML, Louw M 等 2026 Apr 14 置信度 0.82
• Checkpoint inhibitors, obinutuzumab plus PET-adapted ultra-low dose nodal radiotherapy yield high efficacy in treatment-naïve follicular lymphoma: Results from the phase II 'FLUORO' study.
  Follicular lymphoma (FL) first-line chemoimmunotherapy yields high efficacy but serious toxicity in 65% of patients. In high tumour burden treatment-naïve FL, we aimed to exploit known immunostimulatory and cytotoxic properties of combination checkpoint i…
  pubmed Martynchyk A, Chong G, Khor R, Lee D 等 2026 Jun 置信度 0.82
• Posterior Cortex Deafferentation Following Surgical Disconnection Revealed by 18 F-FDG PET/MRI Fusion.
  An 8-year-old girl was diagnosed with epileptic encephalopathy, which progressed to Lennox-Gastaut syndrome. She experienced daily episodes of behavioral arrest and frequent drop attacks, resulting in cuts and injuries. In 2019, she underwent a lesionectomy to…
  pubmed Cruz ME, Santos MV, Thomé Ú, Sakamoto AC 等 2026 Aug 1 置信度 0.82
• A guide-magnetic-field-free modular array diode for efficient electron beam pumping in excimer lasers.
  Diode is one of the most important elements in the excimer laser, which is used to generate and accelerate electron beams to pump laser. Traditional large-area electron beam diodes for excimer laser pumping rely on guiding magnetic fields to confine the electr…
  pubmed Yan W, Lai D, Zhang M, Huang C 等 2026 Apr 1 置信度 0.82
• In Situ Study of p53, MDM2, and MDMX Protein Interaction in Living Cells Using Fluorescence Triple Correlation Spectroscopy.
  The tumor suppressor protein p53 is a crucial transcription factor that regulates physiological processes, including apoptosis, cell cycle progression, DNA damage stress and repair, and programmed cell death. The activity of the intracellular p53 protein is ti…
  pubmed Lu X, Zang K, Diao C, Dong C 等 2026 Apr 21 置信度 0.82
• Targeted immunoPET imaging of multiple myeloma.
  Current standard of care methods of imaging multiple myeloma disease burden are suboptimal. For example, fluorodeoxyglucose-(FDG)-PET/CT may fail to detect up to 50% of myeloma lesions. Immunologically based positron emission tomography (immunoPET) is an imagi…
  pubmed Ulaner GA, Landgren O 2025 Oct 置信度 0.82
• Expansion-Driven Self-Magnetization of High-Energy-Density Plasmas.
  Understanding plasma self-magnetization is one of the fundamental challenges in both laboratory and astrophysical plasmas. Self-magnetization can modify plasma transport properties, altering the dynamical evolution of plasmas. Multiple high-energy-density (HED…
  pubmed Lezhnin KV, Totorica SR, Griff-McMahon J, Medvedev MV 等 2026 Mar 20 置信度 0.82
• Multiparametric MRI-based Deep Learning and Radiomics for Evaluating Lymph Node Metastasis in Early-Stage Cervical Cancer.
  Purpose To develop a multiparametric MRI-based radiomics model and deep learning-radiomics (DLR) fusion model for preoperative prediction of lymph node metastasis (LNM) in early-stage cervical cancer. Materials and Methods In this multicenter retrospective stu…
  pubmed Bao YH, Xiao ML, Li YA, Ma FH 等 2026 May 置信度 0.82
• GLI1 -Rearranged Tumors of the Gynecologic Tract : A Detailed Clinicopathologic Study of 10 Cases.
  GLI1 -rearranged tumors of the gynaecologic tract are rare, but likely under-recognised, neoplasms, which have recently been reported in the ovary and uterus. It is important to identify these neoplasms due to their malignant potential and possible responsiven…
  pubmed Zyla RE, Howitt BE, Bosse T, van Slooten FE 等 2026 Jul 1 置信度 0.82
• Fangchinoline restores TFEB-driven lysosomal biogenesis and blocks H1N1 infection.
  Influenza A viruses subvert lysosomal function to evade host degradation mechanisms. Using Connectivity Map (CMap) screening and transcriptomic analysis, we identified fangchinoline (Fan)-a bisbenzylisoquinoline alkaloid-as a potent enhancer of lysosomal gene …
  pubmed Cheng CQ, Xie F, Liu Z, Li JL 等 2026 Aug 置信度 0.82
• Population genetic diversity in the annual breeding area of the Spodoptera frugiperda in China.
  The fall armyworm (Spodoptera frugiperda), a globally invasive pest, has established persistent populations in China since its invasion in late 2018, posing a continuous threat to agriculture due to its potential for rapid adaptation and insecticide resistance…
  pubmed Lin JR, Zhang J, Zou Y, Wu ZW 2026 Apr 2 置信度 0.82
• Follicular adenoma of the thyroid with hyalinizing trabecular tumor-like pattern.
  Hyalinizing trabecular tumor (HTT) is a rare and challenging, follicular cell-derived thyroid neoplasm characterized by a trabecular growth pattern, intratrabecular/intracellular basement membrane-like hyaline material, and nuclear pseudoinclusions. HTT is pla…
  pubmed Rossi ED, Piermattei A, Minucci A, Perrucci A 等 2026 Apr 2 置信度 0.82
• Hydrogen sulfide donor GYY4137 attenuates RANKL-induced osteoclast differentiation and multi-nucleation.
  Hydrogen sulfide (H 2 S) is a novel gasotransmitter produced in mammalian cells and is known to various regulate physiological functions. Previous study reported that an imbalance in H 2 S metabolism is associated with defective bone homeostasis. However, the …
  pubmed Takagi T, Inoue H, Morimoto H, Takahashi N 等 2026 置信度 0.82
• Unveiling a Bulk WTaV Multicomponent Alloy With Superior Thermal Properties and Manufacturability.
  Many tungsten (W)-based medium and high entropy alloys (HEA) demonstrate superior microstructural stability and enhanced mechanical properties as compared to pure W, effectively rendering them as viable candidate materials for extreme environments such as nucl…
  pubmed Robin IK, Supakul SN, Tripathi S, Aydogan E 等 2026 Jun 置信度 0.82
• Superficial CIC::DUX4 Sarcoma With Focal WT1 Expression: Histomorphologic Clues and Immunohistochemical Pitfalls.
  CIC::DUX4 sarcoma (CDS) is a rare cutaneous and deep soft tissue tumor in the differential diagnosis of small round blue cell sarcomas. CDS, by definition, is negative for rearrangements in EWSR1, and has been reported to have strong nuclear WT1 expression and…
  pubmed Jiang J, Say B, Brown R, Rieger K 等 2026 Aug 置信度 0.82
• Complement 5a receptor 2 attenuates diabetic kidney disease by promoting mitochondria-associated endoplasmic reticulum membrane formation mediated by PSS-MFN2 interaction.
  Complement-mediated metabolic disorders are considered important contributors to the pathogenesis of diabetic kidney disease (DKD). This study investigated the non-canonical roles of complement 5a receptor 2 (C5aR2) in metabolism and its underlying molecular m…
  pubmed Zhao YY, Wang YH, Li ZH, Chang DY 等 2026 Mar 31 置信度 0.82
• Pancreatic Solitary Fibrous Tumor: A Common Tumor Occurring in a Rare Location.
  BACKGROUND The purpose of this report is to explore the clinicopathological characteristics, diagnosis, and differential diagnosis of primary solitary fibrous tumor (SFT) of the pancreas. This report provides a retrospective analysis of the clinical features, …
  pubmed Zeng Q, Li GP, Chen YP, Song FL 等 2026 Mar 31 置信度 0.82
• Morphological and molecular characterization of skeletal and extraskeletal Ewing family of tumors in a tertiary care center of eastern India.
  Ewing family of tumors (EFT) encompass a group of small blue round cell tumors, including Ewing sarcoma (ES) and EWSR1-negative undifferentiated small round cell sarcoma. The distinction between the EFTs is essential from a clinical perspective due to prognost…
  pubmed Sable MN, Aparnna JN, Purkait S 2026 Jan 1 置信度 0.82
• Extraction, Characterization, and Stability Studies of Bistriazinyl-Derived Carboxylic Acids.
  Separation of An-(III) and Ln-(III) ions will benefit the recycling of used nuclear fuel (UNF). For this purpose, many ligands have been tested over the years, and several separation processes have been successfully demonstrated on the laboratory scale. Curren…
  pubmed Diaz Gomez L, Weßling P, Wilden A, Panak PJ 等 2026 Mar 25 置信度 0.82
• TFMPHGNN: Two-Fold multi-perspective heterogeneous graph neural network for sentiment analysis.
  Sentiment analysis remains challenging due to the complex, intertwined relationships among sentiment expressions, contextual cues, and emotional features distributed across heterogeneous data sources. Conventional deep learning and transformer-based models oft…
  pubmed Agbesi VK, Chen W, Ejiyi CJ, Gosu GS 等 2026 Sep 置信度 0.82
• DCSM-Unet: Dual-path heterogeneous encoder with content-aware guidance and differential feature learning.
  High-precision medical image segmentation is a prerequisite for accurate computer-aided diagnosis, yet it faces a persistent challenge in balancing fine-grained local detail extraction with global context modeling. Conventional CNN-based methods excel at analy…
  pubmed Dong C, You C, Liu W 2026 Apr 置信度 0.82
• Type and Size of Fluorescent Proteins Modulate the Localization of PTEN and Its Fragments, but Have Little or No Effect on Mutant PTEN or Stressed Cells.
  The functions of phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a tumor suppressor, depend on its subcellular localization. At the plasma membrane, PTEN dephosphorylates phosphatidylinositol-3,4,5-triphosphate to inhibit AKT signaling, whereas…
  pubmed Kato T, Kawakami Y 2026 置信度 0.82
• Data Fusion Combining High-Resolution Mass Spectrometry and (1)H-NMR Metabolomic Data with Gluten Protein Content to Assess the Impact of Agro-Sustainable Treatments on Durum Wheat.
  Sustainable food production systems based on the use of biofertilizers and soil improvers are proposed to mitigate agricultural-related environmental impacts and address the climate crisis. In particular, plant growth-promoting microbes (PGPM) and biochar (Cha…
  pubmed Riboni N, Cruz Muñoz E, Muhs C, Mattarozzi M 等 2026 置信度 0.82
• CD8 PET imaging with [(89)Zr]Zr-berdoxam-crefmirlimab in patients with solid tumors: the Phase II iCorrelate study.
  CD8 T cells mediate the effects of cancer immunotherapies. CD8 positron emission tomography (PET) imaging with [ 89 Zr]Zr-berdoxam-crefmirlimab enables whole body CD8 cell assessment and has been shown to be safe in Phase I evaluation. The correlation between …
  pubmed Postow MA, Zang PD, Pal SK, Mauguen A 等 2026 Mar 27 置信度 0.82
• Design and Development of an Automated Pipeline for Medical Hyperspectral Image Acquisition, Processing, and Fusion.
  Automated and comprehensive processing of hyperspectral image data is increasingly important in academic research and medical technology. This study presents an automated processing pipeline that integrates hyperspectral image acquisition, analysis, multimodal…
  pubmed Wühler F, Häußermann TM, Rache A, van Marwick B 等 2026 Feb 25 置信度 0.82
• From a Polymorphous Low-Grade Neuroepithelial Tumor to a Glioblastoma in an Adult Patient with FGFR3-TACC3 Fusion: A Case Report and Literature Review of the Molecular Profile.
  From an epidemiological perspective, polymorphous low-grade neuroepithelial tumor (PLNTY) represents a small proportion of brain tumors encountered in epilepsy surgery series. Their rarity and relatively recent recognition likely contribute to underdiagnosis a…
  pubmed Gurrieri L, Riva N, Tomassini A, Ghigi G 等 2026 置信度 0.82
• Resurrecting the Activity of the RNA Subunit of Human RNase P.
  The RNA subunit of human nuclear RNase P, H1 RNA, has low catalytic activity in the absence of its protein cofactors. To improve H1 RNA activity, we introduced minor structural changes toward the bacterial consensus into its catalytic (C) domain. Incorporating…
  pubmed Li D, Kirsebom LA, Hartmann RK 2026 Mar 27 置信度 0.82
• Molecular recognition and induced dimerization of hnRNP A2/B1 truncations by G-quadruplex single strand DNA.
  Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) is a multifunctional nucleic acid metabolism regulator with established roles in viral infection and tumorigenesis. However, a critical gap exists between the oligomeric state of hnRNP A2/B1 and its f…
  pubmed Shahatibieke D, Tang X, Zheng X, Liu Y 等 2026 Mar 26 置信度 0.82
• Restoration of autophagy-lysosomal function via transcranial focused ultrasound stimulation ameliorates β-amyloid pathology and cognitive deficits in an Alzheimer's disease model.
  Transcranial focused ultrasound (FUS) is a non-invasive neuromodulation technique that regulates intracellular functions and treats brain disorders. In Alzheimer's disease (AD), impaired autophagy-lysosomal pathway (ALP) function leads to the accumulation of &…
  pubmed Wang M, Zhang B, Guo R, Wang H 等 2026 Sep 置信度 0.82
• Lithium-Modified UiO-66-2OH for Improved D(2)/H(2) Separation Performance.
  Efficient separation of hydrogen isotopes (D 2 /H 2 ) is critically important for applications such as nuclear fusion, but it remains highly challenging due to their nearly identical physicochemical properties. In this work, a scalable UiO-66-2OH metal-organic…
  pubmed Xie Y, Su K, Wang W, Yuan D 2026 Apr 6 置信度 0.82
• FOS and FOSB Immunohistochemistry and Molecular Testing Reveal Novel Patterns in Proliferative Fasciitis and Myositis, FOSB Rearrangement in Proliferative Funiculitis, and FOSL1 :: RELA Fusion in Pediatric Proliferative Fasciitis.
  Proliferative fasciitis (PFA) and proliferative myositis (PM) are related benign neoplasms that show large ganglion-like neoplastic cells and harbor recurrent FOS fusions. Proliferative funiculitis (PFU) is a benign mesenchymal lesion of the spermatic cord, wi…
  pubmed Yu S, Cordier F, Baranov E, Odintsov I 等 2026 Jul 1 置信度 0.82
• A critical role for STAT3 Thr714 phosphorylation in NPM-ALK-driven tumorigenesis.
  The oncogenic fusion protein NPM-ALK drives anaplastic large cell lymphoma (ALCL) by activating the transcription factor STAT3. While STAT3 phosphorylation at Y705 and S727 is well characterized, the present study defines a mechanistic role for phosphorylation…
  pubmed Lin X, Yao Y, Moriwaki Y, Tago K 等 2026 Mar 25 置信度 0.82
• Diagnosis and treatment of solitary fibrous tumors of the thyroid gland: the importance of an appropriate diagnostic approach.
  Solitary fibrous tumor (SFT) is a type of fibroblastic neoplasm with characteristic histological features, typically showing cytoplasmic expression of CD34 and nuclear expression of STAT6, associated with NAB2-STAT6 gene fusion. Thyroid localization is excepti…
  pubmed Soriano Palao MT, Abellán Lucas M, Ruiz Manzanera JJ, Cerezuela Fernández de Palencia Á 等 2026 May 置信度 0.82
• Systematic evaluation of transposon vector elements to establish high-producing stable CHO cell pools achieving > 10 g/L monoclonal antibody titers.
  Rapid generation of cell populations capable of producing industrially relevant levels of complex biologics remains challenging. Using wild-type PiggyBac transposase and a CHO-K1 glutamine synthetase (GS) knockout cell line, we screened known and novel vector …
  pubmed Tsachaki M, Peltret M, Laplace TB, Vaxelaire-Hily E 等 2026 Jul 25 置信度 0.82
• The Oncogenic EGFR-SHC1 Fusion Confers Insensitivity to EGFR-TKIs via Dual Activation of N-EGFR Kinase Domain and C-SHC1 Phosphorylation Sites in Lung Cancer.
  Although epidermal growth factor receptor (EGFR) fusions in non-small cell lung cancer (NSCLC) typically show sensitivity to tyrosine kinase inhibitors (TKI), we identified an EGFR-SHC1 fusion subtype that exhibits intrinsic resistance to EGFR-TKI monotherapy …
  pubmed Zheng J, Zhao S, Zhan J, Zhuang W 等 2026 置信度 0.82
• MOSAIC: Multi-scale orientation-aware segmentation and instance classification network for histopathological image analysis.
  Accurate nuclei segmentation and instance classification are fundamental tasks in biomedical image analysis; however, many existing computational models exhibit limited robustness when confronted with scale variability, morphological heterogeneity, and arbitra…
  pubmed Wadood AS, Fauzi MFA, Wong LK, Lee JTH 等 2026 Jun 置信度 0.82
• Neutron-gamma discrimination based on STFT-DFF model and FPGA implementation.
  In the field of neutron-gamma discrimination, traditional discrimination algorithms exhibit poor performance in the low-energy region, while machine learning-based discrimination algorithm face challenges such as difficulty in hardware deployment and poor real…
  pubmed Liu B, Tang Y, Liu X, Liu H 等 2026 Jun 置信度 0.82
• Understanding the Structure and Thermal Stability of Cs(3)UCl(6)(s) in the CsCl-UCl(3) System.
  The present effort details the first synthesis and structural characterization of Cs 3 UCl 6 (s), a compound for which no crystallographic information has previously been reported, despite its significance in the thermochemical evaluation of the CsCl-UCl 3 sys…
  pubmed Padinhare Manissery A, Schorne-Pinto J, Zhoujin Y, Husek A 等 2026 Apr 6 置信度 0.82
• Friction-induced scale-selection in the extended Cahn-Hilliard model for zonal staircase.
  In this work, we describe a possible mechanism to set the radial scale of zonal flows, which may be applicable to the E×B staircase found in the global full-f simulations such as in Dif-Pradalier et al., [Phys. Rev. Lett. 114, 085004 (2015)0031-90071…
  pubmed Leconte M, Hahm TS 2026 Feb 置信度 0.82
• Cytomorphology and Molecular Profile of Hyalinizing Clear Cell Carcinoma of the Lung: A Case With Mucinous Differentiation.
  Hyalinizing clear cell carcinoma (HCCC) of the lung is an exceedingly rare salivary gland-type neoplasm with limited cytomorphologic description. We report a case highlighting these features. A 3 mm incidental left-airway lesion enlarged to 7 mm …
  pubmed Lin JZ, Jager L 2026 Jul 置信度 0.82
• Unstructured transcription factor interactions enable emergent specificity.
  How intrinsically disordered regions (IDRs) shape chromatin binding and nuclear organization of transcription factors (TFs) remains unclear. We used proximity-assisted photoactivation (PAPA), a single-molecule protein-protein interaction sensor, to investigate…
  pubmed Abidi AA, Cattoglio C, Tang NN, Fan VB 等 2026 May 28 置信度 0.82
• Isobaric quantitative proteomics reveals altered extracellular matrix, cytoskeletal, and degradation pathways in glaucomatous trabecular meshwork cells.
  Glaucoma trabecular meshwork (GTM) cells cultured in vitro retain many characteristics of their in situ phenotype. Here, we used isobaric tandem mass tags (TMTpro) to label peptides from glaucomatous and non-glaucomatous TM (NTM) cells to identify differential…
  pubmed Holden P, Sun YY, Zientek K, Wilmarth PA 等 2026 Mar 18 置信度 0.82
• The Cyclin C-CDK8/19 Mediator kinase module controls PRCC-TFE3 driven senescence in renal epithelium and tumorigenesis in TFE3-RCC.
  TFE3-rearranged renal cell carcinoma (TFE3-RCC) is an aggressive kidney cancer driven by oncogenic TFE3 fusion transcription factors, yet the molecular machinery that enables these fusions to reprogram transcription and drive tumor growth remains poorly define…
  pubmed Kuroda S, Funasaki S, Nishizawa H, Schmidt LS 等 2026 May 置信度 0.82
• Breaking the shackles of morphology: a novel perspective on immunotherapy evaluation for nasopharyngeal carcinoma using multimodal imaging and radiomics - a review.
  Nasopharyngeal carcinoma is a highly aggressive malignant tumor, and research into its immunotherapy has attracted considerable attention in recent years. Imaging assessment plays a pivotal role in monitoring the efficacy of immunotherapy. Traditional evaluati…
  pubmed Yang S 2026 置信度 0.82
• An efficient C-to-U RNA recorder as a tool for profiling targets of RNA-binding proteins.
  STAMP (Surveying Targets by APOBEC-Mediated Profiling) employed the fusion protein between an RBP and the C-to-U editing enzyme APOBEC1 to mark and determine RBP's target transcripts. It exhibited wonderful performance in mammals, however, it was confirmed not…
  pubmed Li C, Jia Y, Ye T, Zheng L 等 2026 Jul 25 置信度 0.82
• 4-Methylcatechol prevents deoxynivalenol-induced claudin-4 internalization and restores barrier integrity via Nrf2 activation.
  Deoxynivalenol (DON) is one of the most prevalent mycotoxins in food and animal feed and poses substantial risks to intestinal health. Although DON is known to impair epithelial barrier function, its molecular mechanisms remain incompletely defined. Nuclear fa…
  pubmed Li E, Horn N, Ajuwon KM 2026 Jun 15 置信度 0.82
• Cell surface oncofetal antigens in prostate cancer: therapeutic potential and radioligand targeting.
  BACKGROUND: In this study, we aimed to identify oncofetal antigens expressed in prostate cancer and systematically examine their potential role using theranostic approaches. Cell surface oncofetal antigens are expressed to a limited extent in adult cells and m…
  pubmed Harbi E, Bilgin GB, Emmett L, Kendi AT 等 2026 Mar 14 置信度 0.82
• GAD-YOLO: a gastrointestinal abnormality detection YOLO model with multi-scale channel attention and residual fusion.
  Gastrointestinal endoscopy is indispensable for early detection and treatment of gastrointestinal diseases. However, the diagnostic precision and sensitivity of current computer-aided diagnosis systems remain limited, particularly for lesions with small size, …
  pubmed Huang F, Li J, Zhang Y, Li X 2026 置信度 0.82
• Driven by Deformable Convolution and Multi-Plane Scale Constraint: A Hazy Image Dehazing-Stitching System.
  Adverse weather conditions, such as fog, degrade image quality and affect the performance of deep learning-based image processing algorithms, whereas advanced driver assistance systems (ADASs) urgently demand image clarity and large-field-of-view perception in…
  pubmed Hu S, Xiao H, Liu C, Song H 等 2026 Mar 1 置信度 0.82
• CrFeVWX (X = Ta or Ti) High-Entropy Alloy: A Theoretical and Experimental Comparative Investigation on Phase Stability.
  Materials capable of withstanding extreme environments open promising opportunities for nuclear fusion reactors. In this study, equiatomic CrFeTaVW and CrFeTiVW high-entropy alloys are investigated as interlayer materials between W and CuCrZr. Monte Carlo and …
  pubmed Martins R, Valadares V, Pereira A, Gonçalves AP 等 2026 Mar 4 置信度 0.82
• The Extracellular Matrix Regulates Invasion in Fusion-Negative Rhabdomyosarcoma via YAP-PIEZO1 Signaling Axis.
  Background : Fusion-negative rhabdomyosarcoma (FNRMS) represents the most prevalent subtype of rhabdomyosarcoma, the most common pediatric soft-tissue sarcoma. Although its invasion is a leading cause of recurrence and poor prognosis, its underlying mechanism …
  pubmed Pan Y, Kim J, Wong BM, Espuny EC 等 2026 Mar 4 置信度 0.82
• Mask-aware foundational-model embeddings for 18F-FDG-PET/CT prognosis in multiple myeloma.
  To test whether internal memory states from a medical foundational segmentation model can serve as compact, mask-aware embeddings for predicting progression-free survival (PFS) in multiple myeloma (MM) from whole-body [ 18 F]FDG PET/CT, and how late fusion of …
  pubmed Guinea-Pérez J, Uribe S, Peluso S, Castellani G 等 2026 Apr 置信度 0.82
• Molecularly Variant Synovial Sarcoma of the Lower Lip: MN1::SSX1 Fusion as a Diagnostic Pitfall in the Head and Neck.
  Synovial sarcoma is a malignant mesenchymal neoplasm typically characterized by SS18::SSX gene fusions. Although most commonly arising in the extremities, it rarely occurs in the head and neck region. We report a case of monophasic synovial sarcoma of the lowe…
  pubmed Wang SK, Yew J, Patel AV, Mandavilli S 2026 Mar 13 置信度 0.82
• BEND2 Immunohistochemistry as a Useful Diagnostic Marker for Astroblastomas With BEND2 Fusion.
  Astroblastoma, MN1 -altered, is a newly recognized entity in the 5th edition of the WHO Classification of CNS Tumors. Its genetic definition is the presence of an alteration, most commonly gene fusions, in the MN1 gene, with BEND2 being the most frequent fusio…
  pubmed Okuno H, Nakashima T, Arai Y, Hama N 等 2026 Jun 1 置信度 0.82
• Computer-aided diagnosis of papillary thyroid carcinoma based on deep learning technology.
  This article examines global thyroid cancer（TC） incidence trends, with emphasis on epidemiological patterns in China, where papillary thyroid carcinoma (PTC) demonstrates disproportionately high prevalence. As the predominant histological subtype…
  pubmed Zhou Y, Yao L, Jin L, Zhan Z 等 2026 Jun 置信度 0.82
• New prostate cancer risk groups by PSMA-PET (PPP3): an international, retrospective, registry-based cohort study.
  Prostate-specific membrane antigen (PSMA)-PET usage in patients with prostate cancer is growing rapidly. Thus, novel risk-group definitions based on PSMA-PET are urgently needed for guidelines, clinical use, and trial study design. We report improved risk clas…
  pubmed Karpinski MJ, Civan C, Rauscher I, Güven O 等 2026 Apr 置信度 0.82
• Prediction of MYC/BCL-2 co-expression in diffuse large B-cell lymphoma using a multimodal fusion model: a retrospective study based on PET/CT habitat radiomics and deep learning.
  BACKGROUND: The co-expression of MYC and BCL-2 proteins in diffuse large B-cell lymphoma (DLBCL) is linked to poor prognosis and resistance to standard therapies. Thus, a non-invasive and accurate method to detect this co-expression before treatment is essenti…
  pubmed He Y, Chen S, Li X, Yi J 等 2026 Mar 11 置信度 0.82
• Novel LUC7L::NUTM1 fusion in PDGFRA-rearranged myeloproliferative neoplasm with eosinophilia: a case report.
  Myeloid/lymphoid neoplasm with PDGFRA rearrangement are a group of haematologic tumors, in which the clonal proliferation of precursor eosinophils leads to persistent eosinophilic hyperplasia, and varying degrees of involvement of the liver, spleen and lymph n…
  pubmed Zhou J, Yao H, Ren J, Sun K 等 2026 Mar 12 置信度 0.82
• Facile induction of immune tolerance by an interleukin-2-TGFβ surrogate agonist.
  CD4 + regulatory T cells (T reg cells) are essential for immune tolerance 1 . Peripherally induced T reg cells (pT reg cells) complement thymic T reg cells by broadening T reg cell reactivity in response to a changing antigenic landscape 2 . Although both TGF&…
  pubmed Sun Q, Barrett AK, Ogishi M, Lyu H 等 2026 May 置信度 0.82
• Clinical Impact of Integrating RNA-Based Next-Generation Sequencing Into the Diagnostic Evaluation of Soft Tissue Sarcomas: Insights From a Single-Center Multidisciplinary Workflow.
  Sarcomas exhibit clinicopathologic heterogeneity, leading to diagnostic and therapeutic uncertainty. This study assesses the clinical value of integrating targeted RNA-based next-generation sequencing (NGS) into a multidisciplinary sarcoma workflow to improve …
  pubmed Sreenath ND, Singh K, Rastogi S, Biswal N 等 2026 Mar 置信度 0.82
• High-Grade Astrocytoma With Piloid Features: An Aggressive Clinicogenomic Entity Distinct From Pilocytic Astrocytoma.
  High-grade astrocytoma with piloid features (HGAP) has recently emerged as an aggressive glioma entity with distinct molecular alterations, yet its clinicogenomic distinction from pilocytic astrocytoma (PA) remains to be fully elucidated. This study aims to cl…
  pubmed Kang J, Kim EE, Lee K, Kim SI 等 2026 Mar 9 置信度 0.82
• Novel antiviral compounds: Synthesis, biological studies on SARS-CoV-2, and structure-activity relationship analysis.
  SARS-CoV-2 has caused a global epidemic, causing grave public health concerns. In this work, we synthesized a library of 28 compounds derived from the fusion of hydroxyethylamine and aniline and evaluated their antiviral activity. During the initial screening,…
  pubmed Kumar S, Mendes RPG, Bansal M, Upadhyay C 等 2026 Jun 置信度 0.82
• Melitidin alleviates escitalopram-induced sub-chronic cardiotoxicity via regulating mitochondrial fission-fusion machinery and redox signaling: A biochemical, echocardiographic, and histological study.
  Escitalopram (ETP) is a selective serotonin reuptake inhibitor anti-depressant drug that is reported to cause cardiac impairments. Melitidin (MLD) is a natural flavanone that exhibits marked biological and pharmacological properties. This study was commenced t…
  pubmed Wang Y, Ashfaq H, Alsaleem MA, Alissa M 等 2026 Aug 置信度 0.82
• Region-specific Multi-Omics Modeling for Predicting Acute Radiation-Induced Proctitis in Cervical Cancer Radiotherapy: A Retrospective Analysis.
  IntroductionTo develop and evaluate a multi-omics machine-learning model that integrates clinical variables, dose-volume histogram (DVH) metrics, radiomics, and dosiomics from both the rectum and rectal wall regions of interest (ROIs) to improve prediction of …
  pubmed Xiao G, Quan K, Zeng M, Ye Y 等 2026 Jan-Dec 置信度 0.82
• FADFNet: A fine-tunable and adaptive decomposition-fusion network for cross-dataset low-dose CT and low-dose PET image reconstruction.
  Low-dose computed tomography (LDCT) and low-dose positron emission tomography (LDPET) are pivotal for minimizing radiation risks in clinical practice, yet they inherently suffer from noise-induced image degradation. Although deep learning has advanced low-dose…
  pubmed Qian F, Wang W, Huang Y, Niu M 等 2026 Jun 置信度 0.82
• Efficacy of RET inhibitors in the management of advanced, RET mutated, pheochromocytoma. Pooled analysis of published cases with the addition of 2 new cases.
  PURPOSE: Selective RET inhibitors are approved for treatment of RET-mutant lung and thyroid cancers. RET mutation is a druggable molecular driver of malignant pheochromocytomas/paragangliomas (PPGLs), but few data have been published regarding the efficacy of …
  pubmed Cremaschi V, Laganà M, Turla A, Dondi F 等 2026 Mar 9 置信度 0.82
• A Rare Case of Mediastinal NUT (Nuclear Protein in Testis) Carcinoma Presenting with Acute Respiratory Failure: A Case Report.
  NUT (nuclear protein in testis) carcinoma is a rare but aggressive cancer, which was first described in 1991. Given the rarity of this enigmatic entity, risk factors are unknown, treatment options are limited, and the prognosis is dismal. We present the case o…
  pubmed Javed H, Ahmad A, Rehman A, Mikula MW 2026 置信度 0.82
• Telomere-to-telomere genome assembly and multiomics analyses illustrate the high accumulation of quercetin glucosides in tetraploid Descurainia sophia.
  Quercetin glucosides are important phytopharmaceutical metabolites in Descurainia sophia seeds, which are widely used in traditional herbal medicine. However, the key genes involved in quercetin glucoside biosynthesis in D. sophia have not been characterized. …
  pubmed Wu W, Wang J, Cai C, Song X 等 2026 Mar 置信度 0.82
• Tolerability and efficacy of chemosaturation in combination with systemic therapy for metastatic uveal melanoma.
  Uveal melanoma is the most common primary intraocular malignancy in adults. Metastatic disease occurs in approximately 40%-50% of patients, the liver being the predominant site of metastasis (>90%). Treatment options include immune checkpoint inhibitors (IC…
  pubmed Kasteleiner P, Grözinger G, Schmehl J, Flatz L 等 2026 Jul 15 置信度 0.82
• Molecular taxonomy of pancreatic neuroendocrine tumors reveals BEND2-fusions-driven transcriptional plasticity and therapeutic vulnerabilities.
  Pancreatic neuroendocrine tumors (pNETs) exhibit substantial clinical and molecular heterogeneity. Using bulk and single-nucleus RNA sequencing, we identify five molecular subtypes: Hedgehog-high, Alpha-like, Hypoxia-high, Gastrin-high, and Progenitor-like. Th…
  pubmed Lu X, Baltzinger P, Xu L, Fattori A 等 2026 Mar 17 置信度 0.82
• Clinicopathological and molecular features of gynecologic perivascular epithelioid cell tumors: a single-center study.
  Perivascular epithelioid cell tumors (PEComas) are rare neoplasms characterized by the expression of both melanocytic and myoid markers. Gynecologic PEComa may show overlapping with smooth muscle tumors and other uterine tumors. The rarity and ill-defined risk…
  pubmed Li H, Sun X, Hou Z, Xin R 等 2026 置信度 0.82