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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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The liver fluke, Fasciola hepatica , is a major parasitic threat to ruminant health and productivity worldwide, with important implications for food security, animal welfare, and zoonotic risk. This study developed and validated a multiplex deep amplicon seque…
preprints
2026
置信度 0.74
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Background Perivascular spaces (PVS) are increasingly recognized as MRI-visible markers of cerebrovascular and glymphatic functions. However, the determinants of regional PVS burden in the preclinical stages of Alzheimer’s disease (AD) remain to be elucidated,…
preprints
2026
置信度 0.74
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ABSTRACT DNA replication dynamics in fission yeast remain incompletely understood, particularly in repetitive regions such as the centromeres and the rDNA. Here, we establish DNAscent—a nanopore sequencing method that detects BrdU-labelled nascent DNA and infe…
preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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The efficacy of transcranial magnetic stimulation (TMS) is often limited by non-adaptive protocols that disregard instantaneous brain states, potentially constraining therapeutic outcomes. Current EEG-guided approaches are hindered by their reliance on motor-e…
preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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The complexity of the brain is increasingly mirrored by the complexity of the neuroscientific literature, yet no individual mind can fully grasp the diversity of scales, methodologies and model organisms. Where human experts flag, the latest AI models excel: l…
preprints
2025
置信度 0.74
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Applications of artificial intelligence (AI) to histopathology are now common, but most require supervision which inherently limits their scope. By using self-supervised learning (SSL), we discover and quantify the full range of histopathological appearances i…
preprints
2025
置信度 0.74
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In order to understand the constantly changing acoustic world our brains must maintain elements of auditory scenes in memory. The neural mechanisms for this fundamental process remain unclear. Here, we report human intracranial recordings of 1269 single neuron…
preprints
2025
置信度 0.74
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During their expansion out of Africa, modern humans interbred with Neanderthals, leading to the introgression of Neanderthal DNA into their genomes. This initial dispersal created, in Europe, a Southeast–to–Northwest gradient of Neanderthal ancestry in Europea…
preprints
2026
置信度 0.74
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In humans, the first year of life is characterized by rapid developmental changes, including substantial brain maturation. As a result, neural responses to auditory stimuli undergo marked changes during this period. In this study, we followed 69 infants across…
preprints
2026
置信度 0.74
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ABSTRACT Neurotoxic protein fragments such as amyloid-beta and tau accumulate in characteristic staging patterns in Alzheimer’s disease (AD). The brain clears such metabolic substances via multiple different systems, including via the glymphatic (extracellular…
preprints
2025
置信度 0.74
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Abstract Cortical folds encode the architecture of human cognition, yet the mechanisms that transform the smooth fetal cortex into its convoluted geometry remain elusive. Biophysical modeling enables mechanistic insight into cortical morphogenesis, but existin…
preprints
2026
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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Abstract Exposure to asbestos is the primary cause of mesothelioma, however the processes underpinning its initiation and evolutionary trajectory remain elusive. To address this knowledge gap, we conducted whole exome sequencing and phylogenetic analysis of 27…
preprints
2026
置信度 0.74
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Environmental surveillance for human pathogen detection is crucial for safeguarding public health; however, traditional approaches are often time-consuming, equipment-intensive and workflow-complex, delaying actionable public-health decision-making. The integr…
preprints
2026
置信度 0.74
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ABSTRACT Error recognition is fundamental to adaptive behavior, enabling rapid compensatory action when outcomes deviate from expectations. Central to this function are neural circuits for performance monitoring, encoding cognitive signals that could support m…
preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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Tracking prey or recognizing a lurking predator is as crucial for survival as anticipating their actions. To guide behavior, the brain must extract information about object identities and their dynamics from entangled sensory inputs. How it accomplishes this f…
preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2024
置信度 0.74
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Abstract Unveiling the dynamics and energy dissipation involved in atomic scale motion is key to understanding surface catalysis 1–3 , molecular motors 4,5 , and single molecule manipulation 6,7 . Despite significant progress in nanoscale friction 8–10 studies…
preprints
2025
置信度 0.74
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In two-photon imaging of neuronal activity it is increasingly common to acquire 3-dimensional volumes. However, these volumes are typically processed plane by plane, leading to uncorrected axial movement, duplicated cells across planes, reduced signal-to-noise…
preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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Brain disorders are increasingly understood as disorders of distributed brain circuits, yet functional connectivity (FC), the dominant framework for mapping them, treats the brain as a collection of pairwise relationships between regions and cannot represent p…
preprints
2026
置信度 0.74
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Abstract Newer-generation tyrosine kinase inhibitors (TKIs) have shown increasing efficacy in cancers driven by specific mutations, with epidermal growth factor receptor (EGFR) alterations remaining the most common actionable targets in non-small cell lung can…
preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2026
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2024
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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ABSTRACT The human gastrointestinal tract (GIT) is central to human physiology, yet our understanding of the metabolite, microbial, and hormonal spatiotemporal dynamics in humans is limited. Here, we employ naso-enteral intubation to generate a spatiotemporall…
preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2023
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2026
置信度 0.74
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Synthetic biology aims to engineer or re-engineer living systems. To achieve increasingly complex functionalities, it is beneficial to use higher-level building blocks. In this study, we focus on oscillators as such building blocks, propose novel oscillator-ba…
preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2024
置信度 0.74
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europepmc
2026
置信度 0.80
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Cells are the fundamental units through which genetic variation and pharmacological perturbations influence disease processes and therapeutic responses. However, cellular responses to intervention are strongly shaped by biological context, creating a central c…
pubmed
Jia Y, Xing X, Han H, Zhao Y 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Replicating brain-like computation with fluidic memristors offers advantages in energy efficiency and chemical responsiveness over solid-state devices, yet scaling remains challenging due to complex fabrication and their amorphous nature. Herein, we developed …
europepmc
2026
置信度 0.80
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Revealing the working mechanisms of the brain and constructing brain-like machines has long been a goal of humanity. However, due to limitations in observational techniques, simultaneous high spatial and high temporal resolution imaging of the entire brain rem…
pubmed
Liu J
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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Remote sensing and environmental monitoring have significantly advanced with the emergence of hyperspectral image processing techniques, offering unparalleled detail in spectral analysis. Traditional remote sensing methods, such as multispectral and panchromat…
pubmed
Lekha PS, Sirisha BL
2026
置信度 0.82
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Multimodal photonic information systems are redefining the landscape of data storage and encryption by harnessing a diverse range of optical channels and stimuli-responsive materials. Within these interactive photonic platforms, information can be encoded not …
pubmed
Kim H, Yoo J, Huh K, Park J 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Lagrangian strain imaging requires knowledge of the prior state of the deformation at its very core and can be accomplished if all three components of the displacement vector field can be accurately estimated. However, most ultrasound imaging is still performe…
pubmed
Varghese T
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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The convergence of artificial intelligence (AI) and multi-omics is redefining plant science. It moves plant biology from descriptive to predictive and systems-level understanding. Multi-omics frameworks reveal molecular networks driving plant growth, stress ad…
pubmed
Yashi, Kumar N, Kumar R, Singh RK
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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This article reappraises brain function by reconsidering the role of cerebral fluid dynamics in cognition. Tracing a lineage from early modern thinkers like Descartes-who invoked hydraulic metaphors and 'animal spirits'-to J.C. Bose's pioneering studies on ele…
europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Recent interdisciplinary research has raised interest in whether non-classical physical principles may impose fundamental constraints on how neural information can be observed, extracted, or decoded. While conventional neuroscience models neural signaling prim…
europepmc
2026
置信度 0.80