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Spatial transcriptomics (ST) technologies profile gene expression while preserving tissue architecture, enabling the study of spatial cellular organization and microenvironmental interactions. However, raw ST data are heavily affected by technical noise, spars…
pubmed
Ansari MI, Alif MN, Zhang W
2026 Aug 1
置信度 0.82
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Cellular states are strongly influenced by spatial context, but single-cell RNA sequencing (scRNA-seq) loses information about local tissue organization, while spatial proteomic assays capture limited marker panels that constrain transcriptomic inference. Inte…
pubmed
Rozenman B, Hoffer-Hawlik K, Djedjos N, Azizi E
2026 Aug 1
置信度 0.82
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Spatial transcriptomics (ST) measures gene expression in intact tissues. In spot-based ST assays, each spot can contain mixtures of multiple cell types. Deconvolution is particularly challenging when closely related cell subtypes share highly similar expressio…
pubmed
Fang H, Qi C, Zou Y, Chen Y 等
2026 Aug 1
置信度 0.82
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Spatially resolved transcriptomics (SRT) enables the investigation of mRNA expression in a spatial context. While several SRT analysis frameworks have been developed, the vast majority of them focus on analyzing individual samples, and do not allow for compari…
pubmed
Cai P, Robinson MD, Tiberi S
2026 Aug 1
置信度 0.82
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Transdermal delivery of macromolecules and biologics is constrained by the barrier function of skin. First-generation microneedle arrays address this issue by penetrating the stratum corneum; however, their passive, diffusion-based release limits delivery dept…
pubmed
Amini M, Li P, Shahsavan H, Poudineh M
2026 Aug 24
置信度 0.82
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Boron neutron capture therapy (BNCT) is a binary radiotherapy that selectively kills tumor cells. Its clinical implementation relies on Monte Carlo (MC)-based treatment planning systems, which are time-consuming and limit clinical workflow efficiency.
pubmed
Li L, Hong X, Wang Y, Huang G 等
2026 Sep
置信度 0.82
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This work presents the NEMA NU2 2018 performance evaluation of the NeuroLF Basic, a compact and fully integrated brain positron emission tomography (PET) system based on 10-mm-long LYSO crystals.
pubmed
Mikhaylova E, Ahnen ML, Barthel H, Debus J 等
2026 Sep
置信度 0.82
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PurposeChronic venous disease (CVD) of lower extremities is a common disease having considerable morbidity and mortality in affected patients. Myopathy in venous insufficiency affects mainly the calf muscles. Undiagnosed and untreated patients experience persi…
pubmed
Kachare MB, Inamdar ZP, Deshmukh V, Kulkarni S 等
2026 Aug 23
置信度 0.82
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Drug repositioning offers a cost-effective alternative to traditional drug discovery. However, computational methods often struggle to capture multi-scale structural patterns and frequently suffer from information loss in deep architectures.
pubmed
Imrana Y, Chen QM, Liu DN, Fang RQ 等
2026 Aug 13
置信度 0.82
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HMG-CoA reductase (HMGCR) is a validated lipid-lowering target, but statin intolerance, variable response, and drug-drug interactions justify exploration of mechanistically distinct modulators. This study prioritized approved drugs that may bind predicted non-…
pubmed
Mohammed QA, Al-Shaheen MR
2026 Aug 12
置信度 0.82
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Accurate earthquake magnitude estimation is critical for mitigating seismic hazards; however, the inherently nonlinear and dynamic characteristics of geophysical data present persistent modeling challenges. To address this complexity, this study proposes a nov…
pubmed
Ahmed N, Abbas S, Fouad Y, Osman AM 等
2026 Aug 23
置信度 0.82
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Chemically fueled supramolecular systems provide a versatile platform for generating nonequilibrium structures and dynamical instabilities, including chemical oscillations and traveling waves reminiscent of biological organization. However, a minimal mechanist…
pubmed
Singh A, Mukherjee N, Mondal J, Ghosh P
2026 Aug 23
置信度 0.82
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Spatial regression effects may depend on covariates in disease-mapping models. For example, the association between infectious disease incidence and risk factors may vary according to climatic factors, such as time, season, and temperature. In this study, we a…
pubmed
Jiang Y, Lin PS, Zhu J, Lin FC
2026 Sep
置信度 0.82
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The correct identification of spinal cord structures in magnetic resonance imaging (MRI) plays a vital role in identifying degenerative spondyloarthrosis, osteophytes, osteochondrosis, haemangioma, osteophytes and physiological lordosis malformations. Delineat…
pubmed
Bala PM, Usharani S, Rajmohan R, Sowrirajan SR
2026 Aug 23
置信度 0.82
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RNA-small molecule binding site prediction is crucial for targeted drug discovery. Sequence-based methods are efficient but often fail to capture structural dependencies between nucleotides, whereas structure-aware graph models can better represent spatial int…
pubmed
Nguyen TL, Quoc Khanh Le N
2026 Aug 22
置信度 0.82
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Metabolism operates as a highly interconnected biochemical network, and its regulation emerges from coordinated changes across many reactions and metabolites. The integration of gene expression profiling data with organism-scale metabolic networks has proven t…
pubmed
Gainullina A, Chikina E, Artyomov M, Sergushichev A
2026 Aug 22
置信度 0.82
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Rice blast caused by Magnaporthe oryzae (M. oryzae) is a dynamic cross-kingdom infection process involving rapid transcriptional reprogramming and spatial tissue remodeling across successive stages. Although single-cell RNA sequencing (scRNA-seq) and spatial t…
pubmed
Zhu Y, Zhang H, Zhang X, Zhao E 等
2026 Aug 22
置信度 0.82
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The spatial behavior of sharks in the Mediterranean Sea remains poorly understood, including for species listed as Endangered on the International Union for Conservation of Nature's Red List, such as the sandbar shark ( Carcharhinus plumbeus ). To help address…
pubmed
Başusta N, Mendez L, Jacquesson E, Soldo A 等
2026
置信度 0.82
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Pancreatic ductal adenocarcinoma (PDAC) comprises heterogeneous classical and basal-like subtypes. Although pancreatic cancer organoids (PCOs) are widely used, normoxic cultures preferentially maintain the classical subtype, limiting their ability to represent…
pubmed
Kumano K, Nakahashi H, Shimomura O, Akashi Y 等
2026 Aug 22
置信度 0.82
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We derive a simple sufficient condition for the local asymptotic stability of spatially discrete, continuous-time reaction-diffusion systems of networked dynamical systems at a homogeneous equilibrium point. The framework explicitly accommodates heterogeneous …
pubmed
Kumar D
2026 Aug 22
置信度 0.82
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Spatial transcriptomics (ST) profiles genome-wide gene expression while preserving the two-dimensional spatial context of mRNA molecules within tissue sections, enabling studies of tissue architecture and microenvironment-associated biology. However, ST analys…
pubmed
Wang H, Chen W, Wu Y, Sun C 等
2026 Aug 21
置信度 0.82
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Cholinergic dysfunction, oxidative stress, neuroinflammation, and proteinopathies are among the major hallmarks of Alzheimer's disease (AD). This study aimed to develop and evaluate the therapeutic potential of multilayered silica-based/chitosan-coated nanopar…
pubmed
Elwakil BH, Helal AM, El-Khatib M, Abdelnaser A 等
2026 Aug
置信度 0.82
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The visual assessment of X-ray coronary angiography (XCA) videos is challenging due to the complex and dynamic structure of the coronary tree. Automated interpretation can improve confidence in identifying stenoses and estimating their severity, thereby suppor…
pubmed
Popp A, Al AAE, Hoffmann M, Laube A 等
2026 Jul
置信度 0.82
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Tailoring thermal radiative properties, including polarization, spectral emissivity, and spatial phase, has attracted an increasing amount of interest in recent years. Polarized thermal emissions can be generated through anisotropic materials, metamaterials, o…
pubmed
Zhang X, Yang C, Cai W, Zhang Z
2026 Aug 19
置信度 0.82
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Precise control and nanoscale confinement of terahertz (THz) fields are essential requirements for emerging applications in photonics, quantum technologies, wireless communications, and sensing. Here, we demonstrate a polaritonic cavity-enhanced THz photorespo…
pubmed
De Fazio D, Castilla S, Soundarapandian KP, Slipchenko T 等
2026 Aug 19
置信度 0.82
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A controlled image dataset of 5814 smartphone photographs is presented for training and benchmarking machine-learning models for indoor illuminance (lux) estimation. All images were acquired using a Samsung Galaxy A16 smartphone mounted on a tripod under fixed…
pubmed
Buryi A
2026 Aug
置信度 0.82
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Palmitoylation is a widely employed strategy for anchoring peptides to lipid membranes, but it can also lead to uncontrolled self-assembly. The lipid moieties can promote clustering into heterodispersed aggregates that distribute unevenly, thereby reducing acc…
pubmed
Toledo-Marcos J, Di Geronimo B, Curcic S, Farkas V 等
2026 Aug 21
置信度 0.82
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The human gut microbiome is increasingly viewed as an active regulator of host physiology, extending beyond earlier taxonomy-centered descriptions of a complex microbial community. Accumulating evidence supports an organ-like conceptual framework in which the …
pubmed
Bi Y, Song W, Glymenaki M, Hu J 等
2026 Aug
置信度 0.82
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Positron emission tomography combined with computed tomography (PET/CT) has transformed the staging and management of cervical cancer, extending far beyond conventional anatomical imaging. ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) PET/CT current…
pubmed
Usmani S, Ahmed N, Burney IA, Kheruka S 等
2026 Jul
置信度 0.82
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Accurate measurement of ocular surface deformation under intraocular pressure (IOP) is essential for understanding eye biomechanics and the progression of pressure-related diseases such as glaucoma. However, existing imaging techniques often involve trade-offs…
pubmed
MacDans V, Balasubramaniam B, Li B
2026 Aug
置信度 0.82
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We demonstrated crystalline silicon-on-sapphire (c-SOS) metasurfaces that convert a Gaussian beam into arrays of complex optical traps, including arrays of optical bottle beams that trap atoms in dark regions interleaved with bright tweezer arrays. The high re…
pubmed
Fang C, Kim M, Mei H, Yang X 等
2026 Aug 19
置信度 0.82
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Understanding population-level variation in bone size and shape is important for general biomechanics, clinical assessments, and for developing heterogeneous human body models used in safety restraint design. Thoracic injuries are common in severe motor vehicl…
pubmed
Hallberg O, Larsson KJ, Davidsson J, Alexandersson A 等
2026
置信度 0.82
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In sports training and athletic performance, fall risk degrades performance and elevates injury incidence, making early warning of pre-fall states critical. Monocular 3D pose estimation often yields incomplete or biomechanically inconsistent skeletons due to o…
pubmed
He L, Wang S, Seo HI, Shen Q 等
2026
置信度 0.82
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Mutations in isocitrate dehydrogenase 1 or 2 (IDH1/2) define a major subgroup of adult-type diffuse gliomas and induce accumulation of D-2-hydroxyglutarate, resulting in extensive DNA and histone methylation changes. This epigenetic reprogramming underlies the…
pubmed
Tralongo P, Ricciardi G, Ballato M, Fiorentino V 等
2026 Aug
置信度 0.82
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Quasimonoenergetic proton beams have long been anticipated in laser-driven ion acceleration, particularly via multispecies targets in radiation pressure and target normal sheath acceleration, yet experimental results are far from expectations, and the underlyi…
pubmed
Jiang S, Shen XF, Rosmej O, Zhu SP 等
2026 Jul
置信度 0.82
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Temporal-network models have provided key insights into how time-varying connectivity shapes dynamical processes such as spreading. Among them, the activity-driven model is a widely used, analytically tractable benchmark. Yet many temporal networks, such as th…
pubmed
Simon Z, Saramäki J
2026 Jul
置信度 0.82
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The self-organization of microbial ecosystems involves a large variety of mechanisms, ranging from biochemical signaling to population dynamics. Among these, the role of motility regulation has been little studied, despite the importance of active migration pr…
pubmed
Dinelli A, Altieri A, Tailleur J
2026 Jul
置信度 0.82
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Alternating (temporally period-2) stripes, clusters, and labyrinths have been observed in chemical and biochemical reactions, in Min-protein dynamics in E. coli and in vitro systems, and in calcium alternans in cardiac myocytes. However, the mechanisms underly…
pubmed
Qu Z, Huang C, Sui F
2026 Jul
置信度 0.82
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The dynamics of thermosensitive FitzHugh-Nagumo neuronal networks under hybrid synaptic coupling and external electric fields is investigated in a ring topology. Numerical simulations show collective behavior ranging from incoherent activity to coherent travel…
pubmed
Nguessap ELF, Roque AC, Ferreira FF
2026
置信度 0.82
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We investigate biased random walks with stochastic resetting to previously visited sites and demonstrate how directional drift fundamentally alters the emergence of localized stationary states. We show that bias acts as a competing mechanism and can weaken or …
pubmed
Sepehrinia R
2026 Jul
置信度 0.82
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Shape-from-focus (SFF) is essential for microscopic three-dimensional morphology analysis due to its non-contact nature and high axial resolution. However, in practical microscopy environments, ambient vibration and multi-source noise often cause unstable samp…
pubmed
Wang Y, Niu Y, Chen J
2026 Aug 21
置信度 0.82
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During early embryonic development, the human neural tube is formed and patterned through spatial regionalization of cell identity, driven by gene regulatory responses to morphogen gradients. However, many of the underlying mechanisms remain unclear. Here, we …
pubmed
Bertilsson F, Degener A, Ibek P, Rathore GS 等
2026 Aug 21
置信度 0.82
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Spatial crowdsourcing (SC) enables the assignment of location-based tasks to mobile users who must travel to specific locations to perform sensing or service activities. However, SC systems often operate in strategic environments where both task requesters and…
pubmed
Bhargavi C, Singh VK, Shukla AK
2026 Aug 21
置信度 0.82
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Maximum aneurysm diameter remains the principal criterion for abdominal aortic aneurysm (AAA) risk assessment, but additional morphologic and biomechanical factors may help explain the heterogeneity of rupture-related vulnerability. This exploratory study aime…
pubmed
Li R, Song Q, Wang X, Wang J 等
2026 Aug 21
置信度 0.82
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Severe traumatic brain injury (sTBI) creates a substantial burden on neurotrauma systems. While geospatial analyses of TBI have focused on injury location, less is known about how patients' residential environments contribute to regional sTBI burden. This stud…
pubmed
Lubin NJ, Mazzarella A, Chan M, Lorman D 等
2026 Aug 21
置信度 0.82
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Since the 1980s, advances in camera and video production technology have been substantial. These changes hold relevance to camera-based methods of forensic video superimposition (VS). This especially applies to the last 20 years, where hardware changes have be…
pubmed
Stephan CN
2026 Aug 20
置信度 0.82
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Street-level urban greenery shapes pedestrians' environmental experiences and psychological well-being, making accurate assessments essential. However, metrics such as the Green View Index primarily focus on the number of green pixels and often overlook the qu…
pubmed
Kang S, Lee M, Hwang S
2026 Aug 21
置信度 0.82
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Attenuation artifacts remain a critical challenge in cardiac Myocardial Perfusion Imaging (MPI) using Single-Photon Emission Computed Tomography (SPECT), often degrading diagnostic accuracy and clinical interpretability. While hybrid SPECT and Computed Tomogra…
pubmed
Vu HM, Pham TK, Nguyen THC, Nguyen HD 等
2026 Aug 18
置信度 0.82
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We directly observe and spatially map an optical analog of the Magnus effect, where intrinsic spin-orbit-like coupling of light generates a spin-dependent transverse displacement of the atom-light interaction profile for a ^{40}Ca^{+} ion. Probed on a quadrupo…
pubmed
Leindecker P, Gallagher LPH, Brucke E, Zehnder D 等
2026
置信度 0.82
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Nonlocal metamaterials have recently attracted considerable attention across different areas of wave physics, owing to their ability to translate long-range interactions among meta-atoms into a wide array of wave vector-dependent responses and functionalities.…
pubmed
Ciabattoni M, Monticone F
2026 Aug 21
置信度 0.82
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This paper investigates a reconfigurable intelligent surface (RIS)-aided hybrid beamforming (HBF) framework for downlink multi-user millimeter-wave (mmWave) systems operating under practical hardware constraints. Given the severe path-loss disparity and blocka…
pubmed
Tran HM, Dinh TV, Nguyen HT, Nguyen HT
2026
置信度 0.82
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To address the strong dependence of space object orbit prediction on physical models and initial conditions, as well as the difficulty of completely eliminating prediction errors, this study proposes a satellite orbit prediction correction method that integrat…
pubmed
Luo Q, Ji J, Yang T, Xu Y 等
2026
置信度 0.82
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Visual degradation caused by adverse meteorological conditions, such as low light and rain, significantly hinders the deployment of salient object detection (SOD) on edge devices. Existing methods often rely on computationally expensive restoration preprocessi…
pubmed
Wei W, Shi Y, Gao S, Wei M
2026 Aug 21
置信度 0.82
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Climate variability plays a fundamental role in desert locust population dynamics, yet most existing modelling and optimal control frameworks rely on simplified representations of seasonal forcing that inadequately capture short-term climatic variability. To a…
pubmed
Mamo DK, Kinyanjui MN, Siewe N
2026 Aug 21
置信度 0.82
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Change detection using bi-temporal satellite imagery is an important problem in earth monitoring that aims at identifying and localizing surface changes between a temporal acquisition and distinguishing actual pseudo-changes due to seasonal cycles, atmospheric…
pubmed
Gupta D, Singh OP, Mahapatra S
2026 Mar 10
置信度 0.82
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This paper proposes a local meshless collocation method based on global radial basis function (G-RBF) for one-dimensional convection-diffusion equations. The method transforms the equation into a steady-state form through time forward Euler discretization and …
pubmed
Zheng K, Xing C, Lan Y, Hou E
2026 Jul-Sep
置信度 0.82
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Pulsed field ablation (PFA) is a novel non-thermal ablation modality that has demonstrated efficacy and safety in the treatment of common arrhythmias such as atrial fibrillation (AF) and atrial flutter (AFL). However, evidence regarding its use in patients wit…
pubmed
Chinybayeva A, Yerikkyzy M, Suleymen Z, Yessimbekova E 等
2026 Aug
置信度 0.82
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Breast cancer is a leading cause of morbidity and mortality among women worldwide, and the limitations of conventional imaging, especially in women with dense breast tissue have sparked interest in safer, more accessible diagnostic alternatives. Microwave brea…
pubmed
Akesson I, Kovac R, Son H, Teixeira de Castro Gonçalves Ortega AC 等
2026 Sep 20
置信度 0.82
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Sports coaching research remains polarised between direct instruction approaches emphasising feedback and repetition vs. constraints-led approaches favouring athlete discovery through task design. This debate persists partly because existing methods cannot dis…
pubmed
Carvalho HM, Miguel CG, Gonçalves CE
2026
置信度 0.82
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Hybrid brain-computer interfaces (hBCIs) integrate multiple neuroimaging modalities and utilize their complementary information to address the inherent limitations of single-modality neural signal decoding. For electroencephalography (EEG) and functional near-…
pubmed
Gu W, Daly I, He X, Li S 等
2026 Dec
置信度 0.82
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Accurate vehicle trajectory prediction plays a vital role in autonomous driving and intelligent transport systems. Deep learning models like LSTM, CNN, GNN, etc., have shown remarkable performance but often operate in a centralized setting, aggregating raw tra…
pubmed
Joshi A, P A, Prajapati V, Anbalagan S 等
2026
置信度 0.82
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Mass spectrometry imaging (MSI) generates high-dimensional spatial-spectral data that requires efficient computational methods for tissue classification and candidate biomarker feature extraction. Deep learning offers a promising approach, yet the interpretabi…
pubmed
Xu G, Gan S, Guo B, Yang L
2026 Nov 15
置信度 0.82
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Umami peptides are a class of functional biomolecules that significantly enhance food flavor, holding substantial application value in the food industry and nutritional science. Traditional prediction methods rely heavily on manual feature engineering, failing…
pubmed
Wang P, Liu W, Hang B
2026 Aug 20
置信度 0.82
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sEMGCareHCI presents a low-cost, non-invasive surface electromyography (sEMG)-based system for recognizing finger positions and gestures from forearm muscle activity. The proposed "Spatio-Temporal Attention Model (STAM)" combines handcrafted time-domain featur…
pubmed
Geddam R, Awais M, Tiwari V, Ghayvat H
2026 Aug 20
置信度 0.82
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Computer-assisted navigation improves spatial orientation during pelvic bone tumour resection but provides no direct three-dimensional feedback regarding the distance between the tumour and planned osteotomy planes. This study evaluated the clinical value of a…
pubmed
Pang D, Song Z, Liu Y, Zhang Y 等
2026 Aug 20
置信度 0.82
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Scaling up the area of photonic-crystal surface-emitting lasers (PCSELs) to produce higher output power while maintaining single-mode operation has been a longstanding objective in photonics and laser physics. Achieving this goal requires two fundamental physi…
pubmed
Zhou M, Pan M, Gautam C, Seth S 等
2026 Aug 20
置信度 0.82
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Ultra-porous TiO₂ scaffolds are architected non-degradable ceramic graft substitutes, but human evidence relating their structural integration to local tissue maturation remains limited. This exploratory study assessed scaffold-associated healing in a p…
pubmed
Jamous R, Nysæther I, Haugen HJ, Lyngstadaas SP 等
2026 Aug 20
置信度 0.82
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Night-shift work in nurses is associated with circadian disruption, sleep disturbance, and increased vulnerability to affective symptoms. However, the neural and metabolic correlates of these alterations remain insufficiently understood.
pubmed
Kang Y, Yang F, Zhao C, Gao M 等
2026 Aug 20
置信度 0.82
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Acute myeloid leukemia (AML) is a genetically heterogeneous and dynamically evolving malignancy in which morphologic remission does not necessarily indicate eradication of disease. Bone marrow examination remains central to diagnosis and response assessment, y…
pubmed
El-Sehrawy AAMA, Abohassan M, Shonazarov I, Abd HH 等
2026 Aug 20
置信度 0.82
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Cone-beam computed tomography (CBCT) is widely used in dental and maxillofacial imaging, but low-dose acquisition introduces strong, spatially varying noise that degrades soft-tissue visibility and obscures fine anatomical structures. Classical denoising metho…
pubmed
Naveed K, Pauwels R
2026 Aug 20
置信度 0.82
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Mitochondrial architecture plays a critical role in cellular function, yet how organelle structure, metabolic density, and subcellular position are jointly remodeled across whole cells remains poorly understood. We applied quantitative 3D soft X-ray tomography…
pubmed
Singh A, Yadav A, Deshmukh A, Singh A 等
2026 Aug 20
置信度 0.82
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In recent years, the integration of RGB and thermal infrared (TIR) images has shown great potential in advancing semantic segmentation, particularly under challenging conditions such as low-light environments and cluttered backgrounds. However, existing models…
pubmed
Wu X, Zhou X, Bao L, Shi R 等
2026 Aug 17
置信度 0.82
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Previous research has demonstrated a robust asymmetry in loudness judgements for rising and falling level tone stimuli, showing greater loudness and loudness change for rising sounds. In the literature, this has been interpreted to reflect an adaptive perceptu…
pubmed
Kolarik AJ, Koblitz A, Moore BCJ, van der Linde I 等
2026
置信度 0.82
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Efficient acquisition of spatial airflow information is vital for organisms to orient within complex environments and detect predators. For scorpions with degraded vision, specialized mechanosensory trichobothria provide a crucial vision-compensatory mechanism…
pubmed
Wang P, Ding Y, Li B, Zhang C 等
2026 Aug 25
置信度 0.82
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Diabetic kidney disease (DKD) and Parkinson's disease (PD) affect different organs but share epidemiological associations and innate immune abnormalities. The extent and cellular basis of reproducible cross-disease transcriptomic convergence remain uncertain.
pubmed
Hu X, Li Y, Luo B, Wang Y 等
2026
置信度 0.82
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Nuclei segmentation is a fundamental but challenging task in computational pathology due to diverse morphologies, blurred boundaries, and staining variations. Despite remarkable progress, existing models often suffer from structural instability under morpholog…
pubmed
Huang J, Wang S, Xue W, Zhang S 等
2026 Aug 20
置信度 0.82
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RAW video restoration is fundamental to high-quality low-level perception and serves as the basis for a wide range of downstream vision applications. While binary neural networks (BNNs) enable efficient lightweight deployment for image enhancement, their defic…
pubmed
Zhu T, Fu Y, Li H, Zhang G 等
2026 Aug 20
置信度 0.82
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Tissues are highly ordered structures, with cellular localization essential to the optimal function of the tissue. In lymph nodes the spatial arrangement of immune cells and their associated with stromal cell architecture is essential for the generation of opt…
pubmed
Vezyrgianni K, Rothery S, Denton AE
2026 Aug
置信度 0.82
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Colorectal cancer (CRC) is a leading cause of cancer-related morbidity and mortality worldwide. Conventional therapeutic modalities-such as surgery, chemotherapy, and radiotherapy-yield suboptimal outcomes in advanced or recurrent disease, while immune checkpo…
pubmed
Wang N, Xia Y, Wang P, He Y 等
2026 Aug 20
置信度 0.82
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BackgroundEmerging evidence suggests that extracranial tissues and immune-glymphatic interactions may contribute to neurodegenerative processes in Alzheimer's disease (AD). In this context, neuroimaging studies typically focus on intracranial brain structures,…
pubmed
Ebadi Jalal M, Hamidi R, Harris B, Elmaghraby A 等
2026 Aug 20
置信度 0.82
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BackgroundChronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory disease with variable response to biologic therapy. Tissue-based predictors of treatment response are limited, and conventional eosinophil-focused histopathology has sh…
pubmed
Tidemandsen J, Høj S, Jensen TH, Stampe M 等
2026 Aug 20
置信度 0.82
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EEG-based motor imagery (MI) discrimination is widely utilised in real-life applications, such as brain-computer interfaces (BCIs), due to its non-invasive and comparatively cost-effective nature. However, traditional BCI systems typically rely on a uniform, b…
pubmed
Rahman MKM, Shuvo HMT
2026 Aug 20
置信度 0.82
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Gears present unique inspection challenges due to involute tooth geometries, diverse industrial interferences such as lubricant residues and metallic reflections, and defect scales spanning from micrometer-level cracks to millimeter-level fractures. To address…
pubmed
Gao M, Kang X, Xie T, Zhou K
2026 Aug
置信度 0.82
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Subcellular spatial transcriptomics (SSTs) is transforming biology by revealing where individual RNA molecules are located within intact tissues, providing unprecedented insight into how cells function and interact. Achieving this promise depends on accurately…
pubmed
Rathbun IA, Banskota N, Lehrmann E, Gorospe M 等
2026 Aug 10
置信度 0.82
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The patchy distribution of atherosclerosis within arteries implies the existence of local risk factors that control its development. Many hypotheses suggest a role for haemodynamic wall shear stress (WSS), but there is disagreement about which particular chara…
pubmed
Weinberg PD
2026 Aug 20
置信度 0.82
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Understanding the spatial distribution of nutrient inadequacy is critical for designing context-specific interventions to improve human health.
pubmed
Sinkhonde KM, Pangapanga-Phiri I, Osman G, Kalimbira AA
2026 Aug
置信度 0.82
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Immune checkpoint inhibitors have improved outcomes for hepatocellular carcinoma, yet most patients do not respond because the tumor's metabolic environment suppresses immune cells. Single-cell RNA sequencing has revealed extensive immune diversity, but conven…
pubmed
Xu Z, Liu Y, Cheng L, Xu J
2026
置信度 0.82
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Retinal diseases are a major cause of preventable visual impairment, and optical coherence tomography (OCT) provides high-resolution cross-sectional imaging for retinal assessment. However, reliable interpretation of OCT B-scans remains challenging because of …
pubmed
Yao Y, Hong J, Zhang R, Hu J 等
2026
置信度 0.82
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Self-driving laboratories accelerate materials discovery by autonomously designing and executing experiments through closed-loop integration of robotics and artificial intelligence. Active learning with Gaussian processes has enabled efficient phase diagram ma…
pubmed
González-García E, Markvoort AJ, Erkamp NA, de Greef TFA
2026
置信度 0.82
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This paper examines associations of atrophy in the amygdala, entorhinal cortex and hippocampus based on magnetic resonance imaging (MRI) and Positron Emission Tomography (PET) scans from two independent cohorts: Alzheimer's Disease Neuroimaging Initiative (ADN…
pubmed
Miller MI, Xie Y, Stouffer KM, Ceritoglu C 等
2026 Sep
置信度 0.82
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How the brain's physical geometry gives rise to its flexible functional repertoire remains a central question in neuroscience. Here, we trained three classes of recurrent neural networks (RNNs) on a working-memory task, forming a graded hierarchy of spatial co…
pubmed
Beyh A, Kim JZ, Bajwa WU, Parkes L
2026 Aug 21
置信度 0.82
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Paired histopathology and spatial transcriptomics data are advancing our understanding of tissue biology and disease, but modeling both modalities at single-cell resolution while mapping local and distal cell-cell interdependencies remains computationally proh…
pubmed
Wu Q, Gong Q, Yuan L, Li Z 等
2026 Aug 6
置信度 0.82
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Quantitative magnetic resonance imaging (qMRI) provides improved sensitivity and specificity to tissue composition and pathological alterations compared with conventional contrast-weighted imaging. Among various qMRI biomarkers, myelin water imaging is of part…
pubmed
Chen Y, Jun Y, Shin HG, Li S 等
2026 Jul 31
置信度 0.82
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Ultrasound-driven shear wave propagation in soft tissue underlies shear wave elastography (SWE) and emerging elastomechanical hypotheses of ultrasonic neuromodulation, both of which require accurate, efficient modeling of radiation-force--induced tissue motion…
pubmed
Pinton G
2026 Jul 30
置信度 0.82
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Large-scale acoustic simulations underpin the development of ultrasound imaging and therapy, but modeling nonlinearity, frequency-dependent attenuation, and absorbing boundaries in heterogeneous tissue remains computationally demanding. We present Fullwave 2, …
pubmed
Sode M, Pinton G
2026 Jul 31
置信度 0.82
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Dendrites develop branching patterns that are critical for their function, yet the mechanisms guiding arbor morphology remain incompletely understood, and quantitative models predicting how signals guide morphology remain limited. The ddaE neuron in Drosophila…
pubmed
Hur M, Hwu PT, Thompson-Peer KL, Mjolsness ED
2026 Jul 30
置信度 0.82
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Single-cell resolution spatial transcriptomics enables transcriptome-wide molecular profiling within intact tissue architecture, providing unprecedented opportunities to investigate cellular organization and disease-associated molecular states in the human bra…
pubmed
Castro Brant A, Aladyeva E, Nguyen-Hao HT, Alltop K 等
2026 Aug 1
置信度 0.82
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Understanding distributed biological systems, particularly neural circuits, requires simultaneous cellular-resolution imaging across millimeter-scale fields of view (FOV). Existing miniature microscopes remain fundamentally constrained by trade-offs among FOV,…
pubmed
Hu G, Deng Q, Qi T, Chen Z 等
2026 Jul 28
置信度 0.82
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Stereotaxic brain surgery is a foundational neurosurgical technique used to deliver chemical, pharmacological, or genetic material to specific brain regions, or to precisely implant electrodes and stimulators. Accurate targeting depends on reliable identificat…
pubmed
Klug A, Ridenour M, Li B, Jacoby J 等
2026 Jul 30
置信度 0.82
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Large-scale neuroimaging datasets are increasingly used to map relationships between brain structure, function, and behavior across the human lifespan. Routinely, analyses exclude participants who moved too much during imaging. While this decision is framed as…
pubmed
Sadil P, Ansari B, Casamento-Moran A, Choe AS 等
2026 Jul 27
置信度 0.82