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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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crossref
Lingyu Linda Ye, Qinghua Peng, Dayue Darrel Duan
2025-05-13T13:04:14Z
置信度 0.70
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crossref
Mingzhi Hu, Tian Song, Zhaoyuan Gong, Lin Chen 等
2025-09-24T06:30:26Z
置信度 0.70
-
crossref
Rufaida Wasim, Sumaiya Azmi, Asad Ahmad
2025-10-18T17:34:28Z
置信度 0.70
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Traditional Chinese Medicine (TCM) has a rich history of utilizing natural products for therapeutic purposes, offering a vast library of potential drug candidates.
crossref
Fenella Chadwick
2025-10-08T06:45:36Z
置信度 0.70
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crossref
2015-10-13T21:45:23Z
置信度 0.70
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crossref
2017-08-02T14:31:53Z
置信度 0.70
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crossref
Qisheng Tang, Boliang Li, Wenjun Sun, Shengnan Jiang 等
2025-05-28T02:47:28Z
置信度 0.70
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Triple-negative breast cancer (TNBC) is an aggressive subtype with a high propensity for bone metastasis and limited treatment options. Although many proteins drive metastasis, most remain inaccessible to conventional small-molecule drugs due to lack of suitab…
pubmed
Zhou W, Jin J, Liang XH, Yan Y 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
-
Major depressive disorder (MDD) and problematic alcohol use (ALC) commonly co-occur, yet the extent, genomic distribution, and biological context of their shared genetic architecture remain incompletely understood. Here, we integrated genome-wide and local gen…
pubmed
Chen G, Zhu X, Chu C, Qin Z 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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Objective and non-invasive markers for psychiatric assessment remain limited. This study evaluated whether standardized tongue and facial color features provide measurable information relevant to depression and schizophrenia classification. Tongue and facial i…
pubmed
Gao L, Zhang M, Li Y, Wang L 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Background: Chronic psychological stress drives metastasis in triple-negative breast cancer (TNBC), yet the underlying mechanisms remain poorly understood and effective interventions are lacking. Stress-induced expansion of myeloid-derived suppressor cells (MD…
pubmed
Ma M, Li G, Xu Q, Zhang G 等
2026
置信度 0.82
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We conducted a systematic review and meta-analysis to evaluate real-world safety outcomes associated with Janus kinase (JAK) inhibitors in patients with moderate-to-severe atopic dermatitis (AD).
pubmed
Li M, Ni J, Zhang L, Chen C 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Perioperative neurocognitive disorders (POCD) are a class of common complications of central nervous system after general anesthesia and surgery. Sevoflurane (SEV) is a widely used inhalation anesthetic in clinical practice, but the mechanism of SEV-induced ne…
europepmc
2026
置信度 0.80
-
Extended reality (XR) technologies have made remarkable progress and been widely applied in orthopedic surgical education, offering a valuable and innovative pathway for traditional surgical training paradigms. Current reviews have not yet systematically synth…
europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Acute myocardial ischemia (AMI) is a life-threatening cardiovascular disorder characterized by excessive oxidative stress and persistent inflammatory cascades, yet safe multi-target natural therapeutic agents remain scarce. Cinnamomum migao is a well-known Mia…
pubmed
Li X, Zhang Y, Dai W, Xia M 等
2026
置信度 0.82
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Liver cirrhosis remains a challenging global health issue for which current treatment options are largely limited to managing acute liver failure, with no definitive curative therapies available. The Ruangan Huayu Formula (RGHY) has shown promising clinical ef…
pubmed
Xie H, Wang Y, Zhu M, Hou L 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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Herbal self-assembled nanoplatforms (H-SANs) represent an emerging strategy in herbal nanomedicine by integrating the intrinsic bioactivity of phytochemicals with supramolecular nanoscale organization. Unlike conventional nanocarriers that may be limited by lo…
pubmed
Zou X, Liu J, Ren X, Hu Y 等
2026
置信度 0.82
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Current clinical strategies emphasize delaying total hip arthroplasty (THA) in patients with nontraumatic osteonecrosis of the femoral head (NONFH). However, it remains unknown whether prolonged abnormal joint mechanics during this delayed period compromise th…
pubmed
Chen Q, Zhang K, Hao Y, Lu C
2026
置信度 0.82
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europepmc
2026
置信度 0.80
-
Fentanyl and morphine are commonly prescribed opioids for cancer-related pain; however, the comparative associations between these agents and clinical outcomes in critically ill patients with malignancies remain unclear. This study aims to examine the associat…
pubmed
Shui H, Huang W, Xie Z, Wang D 等
2026
置信度 0.82
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BackgroundArtificial intelligence (AI) has generated rapidly growing research in breast cancer diagnosis and treatment, yet its intellectual structure, collaboration patterns, and thematic evolution remain unmapped.ObjectiveTo analyze the global research lands…
europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Chronic respiratory diseases cause substantial global morbidity and mortality, yet the shared genetic architecture of pulmonary-function traits, exposure-related phenotypes, and cardiometabolic traits remains incompletely characterised. We applied genomic stru…
pubmed
Chen G, Chen Y, Chu C, Zhu X
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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The BMP2-Smad signaling pathway serves as a central regulator of osteoblast differentiation and bone formation, rendering it a promising target for the discovery of osteogenic agents from natural sources. Nonetheless, direct BMP2-binding ligands derived from c…
pubmed
Dong M, Wang X, Liu X, Feng T 等
2026
置信度 0.82
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The Traditional Chinese Medicine (TCM) Inheritance Computing Platform (V3.0) provides advanced data-mining capabilities for analyzing large-scale clinical data, enabling systematic extraction of prescription patterns and therapeutic principles.
pubmed
Zhu Z, Tao F, Li W, Chang Y 等
2026
置信度 0.82
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Chronic cough is most commonly associated with respiratory or gastroesophageal disorders, whereas central nervous system etiologies are rare. Cerebellar tonsillar herniation is typically characterized by neurological manifestations, but cough as an isolated sy…
pubmed
Li N, Guo J, Hu Y, Yi Z 等
2026
置信度 0.82
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pubmed
Jin Z, Yun L, Cheng P
2026
置信度 0.82
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europepmc
2026
置信度 0.80
-
Despite the centrality of syndrome differentiation in guiding personalized traditional Chinese medicine (TCM) interventions for coronary heart disease (CHD), existing studies of TCM syndrome distribution are constrained by fragmented methodologies and limited …
europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Pulmonary fibrosis, particularly idiopathic pulmonary fibrosis (IPF), is a progressive and fatal interstitial lung disease with limited treatment options. MicroRNAs (miRNAs) have emerged as critical regulators of fibrotic processes, yet a systematic overview o…
pubmed
Wu F, He Q, Zhang F, Zhang X 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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pubmed
Xia F, Hu Y, Wang Y, Xue M 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
-
The treatment of type 2 diabetes (T2DM) faces numerous challenges. Oral insulin (Ins) and other short-acting compounds still encounter significant obstacles in the hostile gastrointestinal environment, including low bioavailability and rapid metabolic clearanc…
pubmed
Huang J, Han X, Yang L, Shen Q 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Hypoxic pulmonary hypertension (HPH) is characterized by sustained pulmonary vasoconstriction and vascular remodeling caused by chronic hypoxia. The vicious cycle between hypoxia-inducible factor-1α (HIF-1α) activation and reactive oxygen species (…
pubmed
Wu H, Zhou R, Hui W, Qiao S 等
2026
置信度 0.82
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Background : Diabetic foot ulcers (DFUs) are chronic wounds characterized by persistent inflammation, oxidative stress, impaired angiogenesis, and defective extracellular matrix remodeling. Current therapeutic approaches remain insufficient for refractory diab…
pubmed
Lv S, Hu J, Chen H, Zhu M 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Osteoarthritis is an irreversible degenerative joint disease driven by sustained NF-κB-mediated inflammatory responses, and conventional intra-articular hyaluronic acid or small-molecule NF-κB inhibitors cannot achieve targeted on-demand treatment …
pubmed
Zhang D, Zhang Z, Huang D, Sun Z 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Chemotherapy can induce tumor cell death and stimulate immunity, yet its efficacy is often compromised by the immunosuppressive tumor microenvironment dominated by M2-like tumor-associated macrophages (TAMs). Redirecting TAMs toward an M1-like phenotype throug…
pubmed
Wang X, Cai L, Zheng X, Zheng L 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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pubmed
Zhou Q, Tang H, Wang Y, Hua Y 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
-
To investigate the impact of Yishen Jiangzhuo granules on endpoint events in patients with chronic kidney disease (CKD) stages 3-4.
pubmed
Yaqing R, Shiwei R, Binhua YE, Yongxin YU 等
2026
置信度 0.82
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Ocular myasthenia gravis is an acquired autoimmune disorder primarily manifesting clinically as ptosis, diplopia, ocular muscle paralysis, and restricted ocular motility. However, its clinical presentation overlaps with multiple ocular pathologies, leading to …
pubmed
Wang M, Sheng Z
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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Migraine chronification remains difficult to characterize at the individual level, and robust baseline imaging markers associated with subsequent conversion from episodic migraine (EM) to chronic migraine (CM) are lacking. Resting-state functional MRI (rs-fMRI…
pubmed
Xu CY, Zhan SH, Gong Z, Zhang M 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Callosobruchus chinensis (L.) (Coleoptera: Bruchidae) is a destructive storage pest, causing serious losses to stored legume seeds. The olfactory system of these insects plays an important part in assisting them locate host plants. Olfactory responses of femal…
pubmed
Cao Y, Wang K, Hu X, Maggi F 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Electronic health records (EHRs) are a rich source of real-world clinical data, but turning them into valid analyses remains slow, brittle, and expert-intensive. Although recent AI agents can answer medical questions and use tools, automating full EHR workflow…
europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Scutellariae Radix-Coptidis Rhizoma herb pair is a classic traditional Chinese medicine (TCM) combination with heat-clearing, dampness-drying and detoxifying effects, extensively applied clinically against bacterial infections. Traditional water decoction and …
pubmed
Huang Y, Zhao Y, Wei J, Lu J 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80