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• When and Why Hyperbolic Discounting Matters for Reinforcement Learning Interventions.
  In settings where an AI agent nudges a human agent toward a goal, the quality of the AI's policy depends on how well it models the human. Despite behavioral evidence that humans hyperbolically discount future rewards, the RL community continues to model humans…
  pubmed Moore IM, Nofshin E, Swaroop S, Murphy S 等 2025 Aug 置信度 0.82
• Photodynamic therapy and anti-vascular endothelial growth factor for acute central serous chorioretinopathy: An updated systematic review and meta-analysis.
  Acute central serous chorioretinopathy (CSC) may resolve spontaneously, but risks progression to chronic disease with visual impairment. We performed a PRISMA-compliant meta-analysis evaluating photodynamic therapy (PDT) and anti-vascular endothelial growth fa…
  pubmed Algodi HS, Al-Burak SA, Zeng E, Tannar B 等 2026 Sep-Oct 置信度 0.82
• Ocular adverse events associated with aflibercept and faricimab: a population-based pharmacovigilance study.
  To evaluate the postmarketing ocular adverse events (AEs) reported for intravitreal antivascular endothelial growth factor (anti-VEGF) therapies, aflibercept (2 mg and 8 mg), and faricimab (6 mg).
  pubmed Zonouzi SK, Balas M, Arjmand P 2026 Aug 置信度 0.82
• Continuing versus Withholding renin angiotensin aldosterone system antagonists before non-cardiac surgery: A protocol of a systematic review and meta-analysis.
  Perioperative use of ACE inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) has been linked to early postinduction hypotension requiring vasopressor use under general anesthesia, potentially leading to complications like acute renal injury, myocard…
  pubmed Chaouch MA, Haddad F, Kammoun E, Clautiaux H 等 2025 Aug 1 置信度 0.82
• Effect of TNF alpha inhibitors on atherosclerosis in psoriatic arthritis patients: A Systematic Review Protocol.
  Psoriatic arthritis (PsA) is a chronic inflammatory condition associated with joint and skin involvement. Cardiovascular disease, particularly atherosclerosis, is a leading cause of morbidity and premature mortality in PsA patients, due to persistent systemic …
  pubmed Makhlouf Y, Boussaa H, Bettaieb H, Fazaa A 等 2025 Aug 1 置信度 0.82
• Targeting Mycobacterium tuberculosis F(420)-dependent dehydrogenases for new anti-tubercular drug discovery.
  The bacillus Mycobacterium tuberculosis (Mtb) is the aetiological agent of the devastating disease of man, called tuberculosis (TB). Till date, it has remained a major public health problem especially in the global South where significant mortalities are recor…
  pubmed Aderemi AV, Snee M 2026 Jan 置信度 0.82
• Crocetin suppresses colorectal cancer progression by targeting TGM2 and inhibiting the JAK2/STAT3 pathway.
  Colorectal cancer (CRC) is a major health threat with limited therapies for advanced stages. Crocetin, a natural compound from saffron, has broad anticancer potential, but its mechanisms in CRC are unclear.
  pubmed Chen S, Su W, Wang K, Xu M 等 2026 Apr 置信度 0.82
• Rational design of dual ALK inhibitors: scaffolds and strategies to circumvent drug resistance.
  Anaplastic lymphoma kinase (ALK) is a clinically validated oncogenic driver in multiple malignancies; however, the long-term efficacy of ALK tyrosine kinase inhibitors is frequently compromised by tumor heterogeneity, adaptive signaling, and compensatory pathw…
  pubmed Yahya TAA, Al-Qadhi MA 2026 Jun 15 置信度 0.82
• Recent developments in pharmacophore-based modeling of Ca(2+/)Calmodulin-dependent protein kinase II delta (CaMkIIδ) inhibitors for heart failure therapy.
  Calcium/calmodulin-dependent protein kinase II delta (CaMKIIδ) regulates cardiac excitation - contraction coupling and contributes to heart failure onset and progression. Sustained CaMKIIδ activation promotes sarcoplasmic reticulum Ca2+ leak, arrhy…
  pubmed Dauod S, Taha MO 2026 Apr 置信度 0.82
• [Guidelines for the diagnosis and treatment of obstructive sleep apnea in adults (2025)].
  Obstructive sleep apnea (OSA) is a highly prevalent sleep-related breathing disorder with a considerable healthcare burden. Previously, the 2011 guideline for adult obstructive sleep apnea was largely formulated on the basis of expert opinion and consensus, wh…
  pubmed Chinese Thoracic Society 2026 Mar 12 置信度 0.82
• Digital Health Solutions for Type 2 Diabetes and Prediabetes: Systematic Review of Engagement Barriers, Facilitators, and Outcomes.
  Digital health interventions, including artificial intelligence (AI)-driven solutions, offer promise for type 2 diabetes mellitus (T2DM) and prediabetes management through enhanced self-management, adherence, and personalization. However, engagement challenges…
  pubmed Thanthrige A, Wickramasinghe N 2026 Mar 12 置信度 0.82
• Rising burden of severe pediatric coccidioidomycosis: a 25-year single-center study.
  California's incidence of pediatric coccidioidomycosis has risen considerably in the last 25 years, particularly in the last 3 years. Disseminated coccidioidomycosis is rare but associated with substantial morbidity. Sharing our recent and longitudin…
  pubmed Malhotra S, Adachi K, Kaur I, Arribas Garcia P 等 2026 Mar 20 置信度 0.82
• Icotrokinra: An Oral Interleukin-23 Receptor Antagonist Peptide for the Treatment of Psoriasis.
  Psoriasis is a chronic, immune-mediated inflammatory disease with substantial impact on quality of life. While biologic therapies targeting interleukin (IL)-23 and IL-17 have set new efficacy and safety benchmarks, currently available oral agents offer limited…
  pubmed Ferreira C, Torres T 2026 May 置信度 0.82
• Piplartine as an Innovative Natural Product With Dual Antiparasitic and Immunomodulatory Actions.
  Neglected tropical diseases (NTDs) remain a major global health burden, disproportionately affecting low- and middle-income regions and demanding innovative therapeutic strategies. This review summarizes current evidence on piplartine (piperlongumine), a natur…
  pubmed Fukui-Silva L, Souza FCR, Amorim CS, de Moraes J 2026 置信度 0.82
• Efficacy and safety of a low-dose nivolumab regimen (240 mg) as neoadjuvant immunochemotherapy in Chinese patients with resectable non-small cell lung cancer: a prospective single-arm, exploratory study.
  Neoadjuvant immunotherapy has gained increasing importance in the multidisciplinary management of resectable Non-Small Cell Lung Cancer (NSCLC). Based on the CheckMate 816 trial, this study aimed to evaluate the efficacy and safety of neoadjuvant nivolumab in …
  pubmed Cheng Z, Ai Y, Lin Y, Wu Y 等 2026 May 1 置信度 0.82
• Could isotretinoin be a new therapeutic frontier for male infertility? A systematic review and meta-analysis.
  Retinoic acid is essential for spermatogonial differentiation and meiotic initiation, providing a biologically plausible rationale for exploring retinoid-based therapies in the context of male infertility. Isotretinoin is widely prescribed for acne. However, i…
  pubmed Panunzio A, Lujan S, Piccinni B, Greco F 等 2026 Aug 置信度 0.82
• Unveiling the antibacterial efficacy of gold nanoparticles: a critical review.
  The antibiotic exploitation has escalated the menace of drug-resistant bacteria, necessitating the development of powerful new drugs. Gold nanoparticles (Au NPs) are ideal bactericidal agents due to their unique physicochemical properties, non-toxicity, inertn…
  pubmed Janani M, E S A 2026 Mar 10 置信度 0.82
• A Rare Case of Acquired Ichthyosis Related to Pulmonary Tuberculosis.
  Acquired ichthyosis (AI) is a clinical condition associated with keratinization defects, characterized by accumulation of cutaneous scales, with or without epidermal proliferation and inflammation of the dermis. With this report, we want to present the case of…
  pubmed Zangrando C, D'Astolto R, Feliciani C 2025 Sep 置信度 0.82
• Multiple virulence attenuating strategies against Pseudomonas aeruginosa: Natural, synthetic, and synergistic approaches.
  Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that causes severe acute and chronic infections, particularly in immunocompromised patients, those with cystic fibrosis, burn wounds, and structural lung disease. It has numerous virulence factor…
  pubmed Mulat M, Tabassum N, Kim T, Khan F 2026 Mar 10 置信度 0.82
• Clinical outcomes and safety study of CDK4/6 inhibitors in hormone-positive metastatic breast cancer - A real-world tertiary cancer center experience.
  CDK4/6 inhibitors have become the standard of care for the treatment of HR+ metastatic breast cancer (MBC) based on clinical trials. However, real-world experience and efficacy in various subgroups are still lacking. Therefore, we conducted a study to analyze …
  pubmed Sandeep KS, Appachu S, Diwaker RB, Vivek S 等 2025 Oct 1 置信度 0.82
• Reprogramming the tumor immune microenvironment via antibody-drug conjugates.
  Antibody-drug conjugates (ADCs) have revolutionized oncology, yet tumor microenvironment (TME) heterogeneity remains a major barrier. TME-targeted ADCs offer a paradigm shift by specifically modulating immunosuppressive cellular crosstalk and stromal component…
  pubmed Xu T, Gu Y, Guan X 2026 Feb 置信度 0.82
• Effect of baxdrostat on ambulatory blood pressure in patients with resistant hypertension (Bax24): a phase 3, randomised, double-blind, placebo-controlled trial.
  Aldosterone dysregulation is an important contributor in the pathogenesis of hard-to-control hypertension. We aimed to assess the effect of baxdrostat, a selective aldosterone synthase inhibitor, on ambulatory blood pressure in patients with resistant hyperten…
  pubmed Azizi M, Brown JM, Dwyer JP, Flack JM 等 2026 Mar 7 置信度 0.82
• Pertuzumab and Pathological Complete Response in Early HER2+ Breast Cancer: A Systematic Review and Meta-analysis of Real-World Studies.
  Human epidermal growth factor receptor 2-positive (HER2+) breast cancer (BC) is an aggressive subtype that is associated with poorer outcomes. Neoadjuvant chemotherapy combined with trastuzumab has significantly improved prognosis, and the addition of pertuzum…
  pubmed Matsas S, Zembala J, Ruiz Simões A, Giuliani Schmitt L 等 2026 Mar 1 置信度 0.82
• Real‑life diagnostic and therapeutic approach to CLL/SLL in tuscany: the 2025 consensus.
  Management of chronic lymphocytic leukemia/ small lymphocytic lymphoma. (CLL/SLL) has undergone a significant paradigm shift, with chemo immunotherapy being virtually abandoned in favor of targeted agents. A panel of CLL/SLL experts from Tuscany proposes an up…
  pubmed D'Amato M, Rapolla CM, Benedetti E, Bocchia M 等 2026 Mar 7 置信度 0.82
• Development of ARL4C antisense oligonucleotide with reduced off-target effects and enhanced efficacy as an anti-cancer drug.
  ARL4C, a member of the small GTP-binding protein superfamily, is overexpressed in the tumor lesions of various cancers. Antisense oligonucleotide (ASO) therapy targeting ARL4C (ASO-1316-A), a 15-mer ASO, has been shown to inhibit xenograft tumor formation. To …
  pubmed Kawai K, Matsumoto S, Harada A, Sada R 等 2026 Apr 置信度 0.82
• Nanomedicine Revolution: Tiny Tech With Big Impact on Health Care.
  The nanomedicine revolution represents a paradigm shift in modern health care, leveraging nanoscale materials to achieve unprecedented precision, personalization, and performance in diagnosis and therapy. Emerging from Feynman's foundational vision of nanotech…
  pubmed Tun NN, Goswami BK, Goktas P, Canchanya NC 2025 Nov-Dec 置信度 0.82
• Anti-VEGF Agents and the Inner Retina in nAMD: A Narrative Review of RNFL and Ganglion Cell Changes.
  Anti-vascular endothelial growth factor (anti-VEGF) therapy is the cornerstone of care for neovascular age-related macular degeneration (nAMD), yet its effects on the inner retina are not widely studied. We conducted a narrative review, guided by the SANRA che…
  pubmed Tsiropoulos GN, Topouzis F, Amoaku W, Panos GD 2026 置信度 0.82
• Low Sunscreen Awareness and Misconceptions in Skin of Colour With Acne-Related Post-Inflammatory Hyperpigmentation: A Cross-Sectional Study Highlighting the Need for Targeted Education.
  Post-inflammatory hyperpigmentation (PIH) is a frequent sequela of acne in patients with skin of colour (SOC). While sunscreen is widely recommended for PIH prevention, little is known about real-world sunscreen practices in this group. This study aimed to eva…
  pubmed Hang X, Lim DS, Byrom L 2026 Aug 置信度 0.82
• Plozasiran: First Approval.
  Plozasiran (Redemplo ® ) is a first-in-class GalNAc-conjugated small interfering RNA (siRNA) designed to reduce hepatic apolipoprotein C-III (ApoC3) production. It is being developed by Arrowhead Pharmaceuticals for the treatment of familial chylomicronem…
  pubmed Syed YY 2026 May 置信度 0.82
• Becotatug Vedotin: First Approval.
  Becotatug vedotin (MEIYOUHENG ® ), an antibody drug conjugate (ADC) targeting epidermal growth factor receptor (EGFR), is being developed by Lepu Biopharma for the treatment of various cancers. In October 2025, becotatug vedotin received its first approva…
  pubmed Blair HA 2026 Apr 置信度 0.82
• Paeoniflorin alleviates nephrolithiasis by targeting serpine1 and inhibiting the NF-κB signaling pathway.
  Paeoniflorin (PF) is a bioactive monoterpene glycoside with well-established anti-inflammatory properties; however, its therapeutic potential and molecular mechanism in nephrolithiasis remain insufficiently defined. In this study, network pharmacology was empl…
  pubmed Sun Y, Zhang X, Chen X, Zhao J 等 2026 Mar 5 置信度 0.82
• A Systematic Review of the Efficacy of KRAS p.G12C Inhibitors in Metastatic Colorectal Cancer: The Current State of Science.
  KRAS p.G12C (c.34G > T) inhibitors have been reported to have varying survival outcomes in CRC patients across studies. Hence, our review aimed to provide a comprehensive understanding of the efficacy and safety of these agents among the CRC p…
  pubmed Boby JM, Ilerhunmwuwa N, Benny JM, Peniche PZ 等 2026 May 置信度 0.82
• Management of Nail Toxicities From Fibroblast Growth Factor Receptor Inhibitors.
  Alterations in fibroblast growth factor receptor (FGFR) signaling are present in many malignancies, including urothelial carcinoma, cholangiocarcinoma, and gastrointestinal cancers, and FGFR inhibitors (FGFRi) play an increasing role in the treatment of these …
  pubmed Patel AB, Fan X, Smith J 2026 Mar 1 置信度 0.82
• Phytochemical and Biological Evaluation of Leaves, Stems, and Roots of Schinus weinmanniifolia Mart. Ex Engl.
  The genus Schinus L. includes plants used in folk medicine with important pharmacological effects. However, little is known about Schinus weinmanniifolia Mart. ex Engl. This study evaluated the antioxidant, photoprotective, antimicrobial, and cytotoxic activit…
  pubmed Andrade J, de Almeida-Apolonio AA, Dantas FGDS, Santos JIDS 等 2026 Mar 置信度 0.82
• An Integrative Workflow Combining Machine Learning and GNPS to Identify Key Anti-Inflammatory Constituents in Honey-Processed Ephedrae Herba (Ephedra sinica Stapf).
  Ephedrae Herba (EH), a traditional Chinese medicine long used for asthma treatment, is commonly processed with honey to yield honey-processed Ephedrae Herba (HEH), a form believed to enhance therapeutic efficacy. This study developed an integrated approach com…
  pubmed Li H, An Q, Guo B, Lu X 等 2026 Mar 置信度 0.82
• A systematic review of artificial intelligence in child and adolescent interventions: from psychotherapy to developmental support.
  The integration of artificial intelligence (AI) into child and adolescent psychotherapy has gained traction in recent years, driven by the increasing demand for accessible and effective mental health services. This systematic review investigates how AI has bee…
  pubmed Mutluer T, Gurel Ficicioglu IE, Uysal M, Ekinci S 等 2026 Mar 置信度 0.82
• Beyond the First Infection: Exploring Recurrence in Pediatric Acinetobacter Cases.
  Recurrent Acinetobacter infections (AIs) pose significant treatment challenges and contribute to an increased healthcare burden. Limited data exist on recurrent infections in pediatric patients, making it essential to better define their clinical and microbiol…
  pubmed Tekin MY, Kanik-Yüksek S, Gülhan B, Erat T 等 2026 Apr 1 置信度 0.82
• Comparative evaluation of artificial intelligence language models on knowledge of dental antibiotic use.
  BACKGROUND: Artificial intelligence–based large language models (LLMs) are increasingly being used across multiple disciplines. In healthcare, as well as in education, research, and information access, the quality, reliability, and accuracy of the respo…
  pubmed Çırakoğlu NY, Doğan M, Duymaz BC 2026 Mar 3 置信度 0.82
• Structural insights of mycobacterial ATP synthase and recent updates on molecular recognition of Mtb ATP synthase inhibitors: a review.
  In mycobacteria , the F 1 Fo-ATP synthase enzyme comprises five polypeptide chains (Chain α, β, γ, ε, δ) and three subunits (Subunit a , b , and c ), respectively. ATP is fundamental for the survival and growth of mycobacterial st…
  pubmed Patel E, Patel B 2026 Apr 置信度 0.82
• Bipolar CD4-targeted dual-DARPin-55/57 lipid nanoparticle enables efficient CRISPR/Cas-mediated HIV-1 DNA excision and reactivation blockade in latent CD4 T cell lines.
  The persistence of HIV-1 latent reservoirs remains the principal barrier to a cure, as viral rebound occurs upon interruption of antiretroviral therapy. CRISPR/Cas genome editing offers a promising strategy to excise proviruses from host genome; however, the a…
  pubmed Mandal S, Baloch AR, Yuan X, Chen J 等 2026 Apr 置信度 0.82
• Artificial intelligence in Combating Antimicrobial Resistance.
  Antibiotic resistance (AR) has become a significant worldwide public health concern in the twenty-first century. Antimicrobial resistance (AMR) occurs when microorganisms, such as bacteria, fungi, parasites, and viruses acquire genetic changes that make them r…
  pubmed Hatim A N, Ammar Abdul Razzak M, Sriram T, Rajkumar Krishnan V 等 2025 Jun 置信度 0.82
• Screening and Docking Molecular Studies of Natural Products Targeting overexpressed Receptors HER-2 in Breast Cancer.
  Breast cancer is the first cancer to affect a community. Because of its extremely high mitotic activity, breast cancer that tests positive for HER 2 is considered to have a poor prognosis. Due to the side effects of chemical drugs, patients are increasingly tu…
  pubmed Nesrine L, Naima M, Souad KT 2025 Jun 置信度 0.82
• Research on the Synergistic Effect of A Novel Apoptosis Inducer Combined with AKT and HSP90 Selective Inhibitors on Hormone-Sensitive and Hormone-Resistant Breast Cancer Cell Lines.
  One of the frequent malignant tumors affecting women is breast cancer. This tumor develops and occurs due to several internal and external factors. Resistance remains a key challenge in modern breast cancer therapy. Novel 1-substituted isatin-5-sulfonamides wi…
  pubmed Diana Igorevna S, Stepan Konstantinovich K, Fedor Borisovich B, Danila Vladimirovich S 等 2025 Jun 置信度 0.82
• Anthracyclines and the Heart: A Double-edged Sword With Therapeutic Hopes.
  Anthracyclines, notably doxorubicin, are potent cytotoxic agents that substantially improved outcomes across numerous malignancies. However, their use is restricted by their cardiotoxicity, a dose-dependent adverse effect that manifests acutely, during treatme…
  pubmed Alotaibi TM, Samman AM, Al Ghamdi AA, Alkhamis FS 等 2026 置信度 0.82
• Preferences of Chinese Dermatologists for Large Language Model Responses in Clinical Psoriasis Scenarios: A Nationwide Cross-Sectional Survey in China.
  Large language models (LLMs) have shown considerable promise in supporting clinical decision-making. However, their adoption and evaluation in dermatology remains limited. This study aimed to explore the preferences of Chinese dermatologists regarding LLM-gene…
  pubmed Yang J, Xu J, Song X, Li C 等 2026 Feb 置信度 0.82
• Abatement of acrylonitrile-induced gastric injury by 2-Methoxyestradiol through inhibition of TLR4/MYD88/phospho-p38 MAPK axis.
  Acrylonitrile (ACN) is a widely used industrial chemical. It has a wide range of toxicities, including gastric mucosal damage. 2-Methoxyestradiol (2ME) is one of the estrogen metabolites with a plethora of beneficial pharmacological activities. This study aime…
  pubmed Hareeri RH, Alharbi HS, Alamoudi AJ, Abdel-Naim AB 等 2026 May 置信度 0.82
• Contemporary approaches to perioperative anticoagulant management in surgical patients: a literature review.
  Perioperative anticoagulation management requires balancing thromboembolic prevention with bleeding risk. With the growing use of oral anticoagulants, this review synthesizes current evidence and guideline recommendations to support safe decision-making. A sys…
  pubmed Budiarto RM, Luthfah N, Saputra PBT, Widiarti W 等 2026 Jan 置信度 0.82
• Immunotherapy with anti-PD-1 or PD-L1 in advanced ovarian cancer: A meta-analysis of randomized trials.
  Ovarian cancer remains the gynecological malignancy with the highest mortality rate. Despite advances in treatment, the median overall survival remains suboptimal. Although there is strong biological rationale for the use of immune checkpoint inhibitors (ICIs)…
  pubmed Vida R, Bartoletti M, Montico M, Pignata S 等 2026 Mar 置信度 0.82
• The Multi-Faceted Landscape of TEAD Inhibition: a 2017-2025 Patent and Literature Review.
  TEAD (Transcriptional Enhanced Associated Domain) is a family of transcription factors whose involvement in the Hippo pathway plays a crucial role in cellular homeostasis and preventing tumorigenesis. Aberrant YAP/TAZ-TEAD activation is a key driver of various…
  pubmed Chen VY, Wan J, Ding X, Ren F 等 2026 Jun 5 置信度 0.82
• AI-enhanced therapeutic drug monitoring for vancomycin and β-lactam antibiotics in critical care: from population PK to bedside algorithms.
  Although sepsis and other severe infections in intensive care are common and deadly, obtaining safe and effective exposure for vancomycin and broad-spectrum β-lactams is difficult because of substantial kinetic variability, operational difficulties with …
  pubmed Al Meslamani AZ, Jarab AS, Merghani Ali Mohammed E 2026 Mar 置信度 0.82
• Effectiveness and safety of intravenous thrombolysis for non-arteritic central retinal artery occlusion: A GRADE-assessed meta-analysis.
  OBJECTIVE: To evaluate the effectiveness and safety of intravenous thrombolysis (IVT) in patients with non-arteritic central retinal artery occlusion (NA-CRAO), using a GRADE-assessed meta-analysis. METHODS: A systematic search was conducted across PubMed, Web…
  pubmed Abbas A, Sabet H, Abo-Elnour DE, Al-Mufti J 等 2026 Jun 置信度 0.82
• The Public Health Burden of Antimicrobial Resistance in Yemen: A Narrative Review.
  Antimicrobial resistance is a global health crisis, with its impact magnified in conflict settings like Yemen, where a decimated health system and humanitarian emergency create ideal conditions for the proliferation of resistant pathogens. A clear understandin…
  pubmed Alsakkaf GEA 2026 Mar 置信度 0.82
• Management of Drug-induced Dyspepsia in Children: Current Evidence and Clinical Approach.
  Drug-induced dyspepsia (DID) represents an often overlooked cause of upper gastrointestinal (GI) discomfort in children, frequently mimicking functional dyspepsia or gastroesophageal reflux disease (GERD). This review synthesizes current evidence on the diagno…
  pubmed Pai UA, Kesavelu D, Wadhwa A, Pillai BV 等 2025 Jul-Dec 置信度 0.82
• Clinical features, treatment, and outcomes of anti-PD-1/PD-L1 immune checkpoint inhibitors induced dermatomyositis.
  This study aims to clarify clinical manifestations, diagnostic methods, treatment approaches, and prognostic outcomes of anti-programmed death (PD-1)/programmed death- ligand 1(PD-L1) drugs-induced dermatomyositis (DM).
  pubmed Xiao J, Xia Z, Yang F, Liao S 等 2026 Apr 置信度 0.82
• Development of a Water-in-Oil Microemulsion Template for Chitosan Nanogel Fabrication via Genipin Crosslinking.
  This study presents a promising strategy for the fabrication of a novel chitosan-based nanogel-in-oil system by integrating the development of a water-in-oil (W/O) microemulsion containing chitosan as a template, followed by crosslinking with genipin, a natura…
  pubmed Hirun N, Kraisit P, Santhan S, Kittiwisut S 等 2026 Feb 13 置信度 0.82
• Optimizing the Flavor Profile of Brazilian Spirits: Torrefaction Modeling of Native Woods for Cachaça Maturation.
  Cachaça , a traditional Brazilian spirit, undergoes significant sensory refinement through barrel aging. In this study, we investigated how heat treatment of Brazilian woods (Balsam, Jaqueira, Jequitibá, Amburana, and Ipê) affects the sensory pr…
  pubmed Reitenbach AF, Lorenzi AS, Catibe NP, Tormena RPI 等 2026 Feb 12 置信度 0.82
• Differentiation Syndrome in Acute Myeloid Leukemia: Molecular Mechanisms, Clinical Spectrum, and Emerging Therapeutic Paradigms.
  Acute myeloid leukemia (AML) is characterized by differentiation arrest, driving blast proliferation, and abnormal blood formation. While differentiation therapy revolutionized acute promyelocytic leukemia (APL) with all-trans retinoic acid (ATRA) and arsenic …
  pubmed Mansour R, Yaseen A, Abdel Rahman Z 2026 Feb 12 置信度 0.82
• From Image-Guided Surgery to Computer-Assisted Real-Time Diagnosis with Hyperspectral and Multispectral Imaging: A Systematic Review in Gynecologic Oncology.
  Background: There is a need for intraoperative image guidance in gynecologic oncologic surgery to provide accurate identification of malignant tissue and ensure negative resection margins. Emerging imaging technologies can complement standard histopathology an…
  pubmed Innocenzi C, Pavone M, Seeliger B, Barberio M 等 2026 Feb 20 置信度 0.82
• A Cyclic Pentapeptide Inhibits AgrC as a Quorum-Sensing Quenching Agent in Staphylococcus aureus.
  Staphylococcus aureus virulence is tightly regulated by the agr (accessory gene regulator) quorum-sensing system. Targeting AgrC, the histidine kinase receptor that serves as a core regulator of agr signaling, represents a promising antivirulence strategy that…
  pubmed Ai D, Duan H, Yao J 2026 Feb 15 置信度 0.82
• Marine-derived Peptides As Anti-biofilm and Anti-virulence Agents: Mechanistic Insights and Applications Against Microbial Pathogens.
  pubmed Kim T, Tabassum N, Javaid A, Hassan MI 等 2026 Jun 置信度 0.82
• Resolution of vanishing bile duct syndrome in a patient associated with refractory hodgkin lymphoma following Anti-PD-1 therapy: a case report and literature review.
  Vanishing bile duct syndrome (VBDS) is a rare, and often fatal complication of Hodgkin lymphoma (HL), characterized by progressive intrahepatic bile duct loss and severe cholestasis. Management remains ill-defined, particularly in patients with refractory HL a…
  pubmed Lin YC, Hsieh WC, Tuan YH, Tseng HH 等 2026 Feb 26 置信度 0.82
• Artificial intelligence-powered prediction of diabetic complications: from clinical data to molecular omics.
  Diabetic complications are a major cause of disability and mortality among patients, and early identification of high-risk individuals is essential for precision prevention and management. In recent years, the rapid advancement of artificial intelligence (AI) …
  pubmed Xie X, Wu C, Huang Z, Zhou Y 等 2026 Jan 7 置信度 0.82
• Chalcones as Multi-target Ligands for Alzheimer's Disease: A Review of Synthetic Strategies and Therapeutic Promise.
  Alzheimer's disease remains a multifactorial neurodegenerative disorder with limited therapeutic options. Chalcones, flavonoid-derived molecules with high structural flexibility and diverse biological activities, have emerged as promising candidates due to the…
  pubmed Antoniolli G 2026 置信度 0.82
• Cost-effectiveness analysis of anti-VEGF drugs in the treatment of visual impairment due to diabetic macular edema: A systematic review.
  PURPOSE: This systematic review aims to evaluate the cost-effectiveness of anti–vascular endothelial growth factor (anti-VEGF) drugs in the treatment of diabetic macular edema (DME), providing a comprehensive synthesis of economic and quality of life ou…
  pubmed Hasoumi M, Alipour V, Ahmadieh H, Arabloo J 等 2026 Feb 25 置信度 0.82
• Multidrug-resistant uropathogens in pediatric urinary tract infections: a multicenter retrospective trend analysis (2020-2024).
  Large-scale public health disruptions, including pandemics and natural disasters, may influence healthcare delivery, pathogen distribution, and antimicrobial resistance (AMR). This retrospective multicenter study evaluated uropathogen profiles and temporal tre…
  pubmed Erdoğan E, Yetişgen A, Doğan S, Sinanoğlu MS 等 2026 May 置信度 0.82
• Factor XI inhibitors versus direct oral anticoagulants for the prevention of thromboembolic events and safety in patients with atrial fibrillation: A systematic review and meta-analysis of randomized controlled trials.
  While DOACs - Direct Oral Anticoagulants are the current standard for stroke prevention, nearly 30-50% of eligible patients remain untreated or undertreated due to perceived or actual bleeding risk. Therefore, evaluating agents that potentially uncouple antith…
  pubmed de Alcântara JPTL, Götz GWXDR, Amaral PEO, Cecchetti G 等 2026 Jul-Aug 置信度 0.82
• Design, synthesis, and antibacterial efficacy of new methylene disalicylic acid/1,3,4-oxadiazole hybrids as dual inhibitors of DNA gyrase and topoisomerase IV.
  DNA gyrase and topoisomerase IV enzymes are promising candidates for dual targeting with novel antibacterial agents, lowering the risk of bacterial resistance development. A new series of methylene disalicylic acid/1,3,4-oxadiazole hybrids (5a-l) was developed…
  pubmed Mohamed FAM, Alanazi HH, Elasbali AM, Alanazi A 等 2026 Aug 置信度 0.82
• AI-Driven Assistive Technology: The Disability Justice Imperative.
  In the field of health informatics, Artificial Intelligence (AI) heralds a new era of assistive technologies, redefining opportunities and challenges for persons with disabilities. This chapter will discuss the role AI plays in developing technological aids. H…
  pubmed Kundi B, Taleghani S, da Silveira Gorman R, El-Lahib Y 等 2025 Oct 3 置信度 0.82
• Nursing Activity Recognition for Automated Care Documentation in Clinical Settings.
  This paper introduces a concept for an assistance system that enables nursing staff in real-life clinical settings to reduce the time-consuming nursing documentation effort, e.g. from the morning routine. The overall goal is an AI-based documentation assistant…
  pubmed Wallhoff F, Hesselmann FT 2025 Oct 3 置信度 0.82
• Intelligent Tutoring Systems for Adaptive Learning Pathways in Healthcare Training.
  Effective training is essential for successful surgical outcomes, yet traditional methods are often resource-intensive and inefficient. This study explores the use of AI-powered Recommender Systems to provide personalized and scalable training in robotic-assis…
  pubmed Eckelt S, Soleymani A, Zheng B, Tavakoli M 2025 Oct 3 置信度 0.82
• Challenges and Future Prospects of Superparamagnetic Iron Oxide Nanoparticles (SPIONs) in Nanomedicine: A Focus on Toxicity, Imaging, and Theranostics.
  Superparamagnetic Iron Oxide Nanoparticles (SPIONs) have emerged as a pivotal tool in nanomedicine, offering potential in drug delivery, imaging, and targeted therapies. However, their application is challenged by issues such as cytotoxicity, uneven biodistrib…
  pubmed Alvandi M, Nosrati S, Mansouri R, Shaghaghi Z 等 2025 Oct-Dec 置信度 0.82
• Cultural Prompting Improves the Empathy and Cultural Responsiveness of GPT-Generated Therapy Responses.
  Large Language Model (LLM)-based conversational agents offer promising solutions for mental health support, but lack cultural responsiveness for diverse populations. This study evaluated the effectiveness of cultural prompting in improving cultural responsiven…
  pubmed Xie SJ, Zhai S, Liang Y, Li J 等 2024 置信度 0.82
• Predicting Chemotherapy-Related Symptom Deterioration Using Hybrid Deep Learning Architecture.
  Predicting symptom escalation in chemotherapy patients is essential for proactive intervention and improved clinical outcomes. This study leverages hybrid deep learning architectures, specifically Convolutional Neural Networks with Long Short-Term Memory (CNN-…
  pubmed Finkelstein J, Smiley A, Echeverria C, Mooney K 2024 置信度 0.82
• AKI-Detector: A Multi-Agent Framework by Integrating Machine Learning and Large Language Models for Early Prediction of Acute Kidney Injury in ICU.
  Acute kidney injury (AKI) is a severe condition in the ICU, where early prediction is crucial for timely intervention and prevention. Traditional machine learning (ML) models lack interpretability, which limits real-world applicability. We propose AKI-Detector…
  pubmed Shi T, Xiao M, Xu H, Zhao H 等 2024 置信度 0.82
• Machine Learning-Based Prediction of Antimicrobial Susceptibility: A Step Towards Precision Antimicrobial Stewardship.
  Antimicrobial resistance (AMR) represents an urgent global health crisis exacerbated by the frequent empirical use of broad-spectrum antibiotics. AMR is exacerbated by inherent delays in obtaining culture results and antimicrobial susceptibility data after sam…
  pubmed Amrollahi F, Haredasht FN, Vansomphone A, Marshall N 等 2024 置信度 0.82
• Pre-formulation development of highly potent nontuberculous mycobacterial agents.
  Nontuberculous mycobacteria (NTM) are pathogens that particularly infect patients with structural lung diseases, such as chronic obstructive pulmonary disease or cystic fibrosis. Several novel indole-2-carboxamides (ICs) that were synthesized in our laboratory…
  pubmed Agrawal SG, North EJ, Dash AK 2025 May 置信度 0.82
• Clinical updates in bowel preparation for colonoscopy.
  Colonoscopy is essential for colorectal cancer (CRC) screening, but its effectiveness depends on adequate bowel preparation (BP), which remains suboptimal in up to 44 % of cases. Poor BP reduces lesion detection, particularly in the proximal colon, and in…
  pubmed Maida M, Grieme AD, Wu Y, Vitello A 等 2026 Feb 置信度 0.82
• Medicinal chemistry advances of SGLT inhibitors: SAR, structural innovation, and mechanistic insights.
  Sodium-glucose co-transporter (SGLT) inhibitors originated as simple C-aryl glucosides but have gradually evolved into clinically proven compounds benefiting metabolism, cardiovascular and kidney function. Between 2010 and 2025, substantial progress has been m…
  pubmed Kabra UD, Umekar MJ, Kabra DG 2026 Apr 15 置信度 0.82
• Dose enhancement by gold, iron oxide, bismuth oxide, and platinum nanoparticles in radiotherapy: a comprehensive meta-analysis.
  This first global comprehensive meta-analysis of 64 studies compares four metal (gold (Au), iron oxide (IO), bismuth oxide (BO), platinum (Pt)) nanoparticles (NPs) as cancer radiosensitizers. Following PRISMA guidelines, we searched PubMed/Medline, Scopus…
  pubmed Malekzadeh R, Gholami S, Mehrabifard M, Khoshdel E 等 2026 Jun 置信度 0.82
• Tumor Necrosis Factor-α Inhibition and the Unmasking of CNS Demyelination across a Large United States Health Research Network.
  To evaluate the risk of demyelinating disease and optic neuritis among patients treated with tumor necrosis factor (TNF)-α inhibitors using a large, nationwide electronic health record database.
  pubmed Muayad J, Mendes J, Mendes F, Chauhan MZ 等 2026 Jul 置信度 0.82
• Efficacy of immune checkpoint inhibitors in the first line therapy of non-squamous non-small cell lung cancer: A systematic review and network meta-analysis.
  By 2026, several PD-1/PD-L1 antibodies were approved by FDA, EMA and non-EU Eastern European countries for the first-line therapy in advanced non-squamous non-small cell lung cancer (nsNSCLC) without EGFR mutations or ALK alterations. This study aimed to compa…
  pubmed Fedyanin M, Zhukov N, Moiseenko F, Mironenko O 等 2026 May 置信度 0.82
• LSD1 inhibitors for anticancer therapy: an updated patent review (2022-2025).
  Lysine-specific demethylase 1 (LSD1) is a key epigenetic enzyme relying on flavin adenine dinucleotide to regulate gene expression via histone H3 demethylation and non-histone substrate modification. Discovered in 2004, it overturned the view that histone modi…
  pubmed Zhang Z, Li J, Wang Z, Zhou J 等 2026 Apr 置信度 0.82
• Zika virus and host protein interactions for understanding molecular mechanisms of pathogenesis and therapeutic development.
  Zika virus (ZIKV) causes severe neurological disease, including microcephaly and Guillain-Barré syndrome, through complex interactions with host cell proteins. This review synthesizes the 2015-2025 published literature on ZIKV-host protein interactions an…
  pubmed Han X, Du J, Li W, Yang S 等 2026 置信度 0.82
• Interleukin-1β as target to induce synthetic lethality in KRAS mutant biliary tract cancer.
  Biliary tract cancer (BTC) frequently harbors KRAS mutations, which are associated with resistance to traditional treatment and a poor prognosis. Synthetic lethality (SL) strategy may provide other targets of KRAS. Therefore, we aim to identify and validate po…
  pubmed Li S, Shan Y, Chen T, Topatana W 等 2026 Apr 置信度 0.82
• Mapping eligibility criteria in oncology target trial emulations using real-world data: a scoping review.
  Target trial emulations often face challenges in accurately identifying the intended target population within real-world data (RWD) because eligibility criteria cannot always be directly mapped to available variables. This scoping review aimed to systematicall…
  pubmed Chen RZ, Balaji S, Bozkurt S, Wallach JD 等 2026 Feb 19 置信度 0.82
• Switching from Originator Tocilizumab to Biosimilar in Giant Cell Arteritis: Evaluation of Effectiveness and Safety in a Multicenter Cohort of 38 Patients.
  Tocilizumab (TCZ) is an interleukin-6 receptor inhibitor approved for the treatment of giant cell arteritis (GCA). Biosimilars of TCZ, such as TYENNE™, are biologic agents which are similar to the originator (RoACTEMRA™) in structure, efficacy, a…
  pubmed Loricera J, Molina-Collada J, Nieto JC, Sánchez-Lucas M 等 2026 Mar 置信度 0.82
• From 2020 to 2025: Comprehensive review Decoding novel structural inhibitors for M(pro) of SARS-CoV-2.
  While the immediate global threat of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has subsided, the virus remains a persistent cause of regional outbreaks and public health concerns. The main protease (M pro ), essential for viral polyprotein p…
  pubmed Zhang X, Xu Y, Jiang Y, Huang J 等 2026 Jun 置信度 0.82
• Disarming carbapenemase-producing Acinetobacter baumannii: high potency of the novel therapeutic combination of meropenem and the innovative diazabicyclooctane β-lactamase inhibitor pilabactam (formerly ANT3310).
  Carbapenem-resistant Acinetobacter baumannii (CRAB) represents an urgent global health threat, with resistance primarily driven by carbapenem-hydrolyzing class D β-lactamases (CHDLs) such as OXA-23. Therapeutic options remain limited due to the scarcity …
  pubmed Rodríguez-Pallares S, Outeda-García M, Lence E, Rodríguez-Coello A 等 2026 Apr 置信度 0.82
• Skin toxicities related to Bruton tyrosine kinase inhibitors: an updated review.
  Bruton's tyrosine kinase inhibitors (BTKi) have transformed the management of B-cell malignancies by selectively targeting signaling pathways essential for malignant B-cell survival, thereby reducing the systemic toxicity of conventional chemotherapy. However,…
  pubmed Cedirian S, Epifani V, Cafasso G, Brunetti T 等 2026 Feb 置信度 0.82
• Benchmarking large language model-based agent systems for clinical decision tasks.
  Agentic artificial intelligence (AI) systems, designed to autonomously reason, plan, and invoke tools, have shown promise in healthcare, yet systematic benchmarking of their real-world performance remains limited. In this study, we evaluate two such systems: t…
  pubmed Liu Y, Carrero ZI, Jiang X, Ferber D 等 2026 Feb 18 置信度 0.82
• Coronary Plaque Progression After Androgen Deprivation Therapy in Men With Prostate Cancer: A Randomized Clinical Trial.
  Androgen deprivation therapy (ADT) for men with prostate cancer (PCa) is associated with cardiovascular (CV) morbidity, yet the biological basis remains unclear. Recent studies have yielded conflicting results regarding the CV safety of gonadotropin-releasing …
  pubmed Patel SA, Yadalam AK, van Assen M, Cantu SM 等 2026 May 1 置信度 0.82
• Identifying cardiac safety signals of disproportionate reporting for CGRP antagonists: evidence from the FDA Adverse Event Reporting System.
  The objective of this study was to investigate the potential association between the use of calcitonin gene-related peptide (CGRP) antagonists and the reporting of cardiac adverse events (cAEs) by analyzing data from the US Food and Drug Administration Adverse…
  pubmed Xu S, Song W, Wang Y, Zhao Y 2026 May 置信度 0.82
• Real-World Effectiveness of RSVpreF and RSVpreF3 Vaccines in Preventing Hospitalization and Emergency Department Visits Associated With Respiratory Syncytial Virus in Older Adults: A Meta-analysis.
  Respiratory syncytial virus (RSV) vaccines were first recommended for older adults during the 2023-2024 season in countries that authorized their use. Although early observational studies complemented trial findings, real-world evidence on vaccine effectivenes…
  pubmed Sumsuzzman DM, Shi C, Moghadas SM 2026 May 20 置信度 0.82
• Computational identification of natural inhibitors targeting GroEL in Leptospira interrogans: an integrative virtual screening and molecular dynamics approach.
  Leptospirosis is a zoonotic disease caused by Leptospira interrogans and represents a major public health and veterinary concern. The persistence of the pathogen is closely associated with biofilm formation, yet targeted therapeutics are currently unavailable.…
  pubmed Sethi G, Sahoo S, Han SC, Shin D 等 2025 置信度 0.82
• Methanol extract of Chenopodium murale L. attenuated TNF-α-mediated oxidative stress and inflammation in murine models.
  Herbal remedies have been utilised in traditional medicine systems to manage chronic illnesses. The present research investigated the antioxidant, anti-inflammatory, and antiarthritic effects of Chenopodium murale L. The C. murale (CMMeE) methanolic extract, p…
  pubmed Elsadek MF, Nasir M, Al-Numair KS, Alshehri EH 等 2026 Mar 置信度 0.82
• Selective Estrogen Receptor Modulators (SERMs): Advances, Challenges, and Future Prospects in ER+ Breast Cancer Therapy.
  Selective estrogen receptor modulators (SERMs) are an important class of drugs mainly useful in the treatment of breast cancer as they act as estrogen antagonists in the breast tissue but have an agonistic activity in bone and the cardiovascular system (CVS). …
  pubmed Saini A, Kalita R, Nath T, Singh AKP 等 2026 Feb 置信度 0.82
• An Update on Mpox: Focussing on Current and Emerging Antiviral Strategies.
  The 2022 global mpox outbreak and subsequent viral evolution have exposed critical limitations in current therapeutic strategies, which predominantly rely on repurposed smallpox drugs targeting a narrow range of viral proteins. This review provides a timely an…
  pubmed Hou Y, Su Y, Li J, Ding J 2026 Mar 置信度 0.82
• Comparative risk of tuberculosis infection with different TNF-α inhibitors in immune-mediated inflammatory diseases: a systematic review and network meta-analysis.
  Tumor necrosis factor-α inhibitors (TNFi) are established to increase the risk of tuberculosis (TB). However, the comparative risk across different TNFi agents remains poorly defined due to a lack of head-to-head comparative studies. This network meta-an…
  pubmed Lv X, Liu Y, Li Y, Zhang Q 等 2026 置信度 0.82
• From glucosuria to dialysis: a case report of osmotic nephropathy due to an SGLT2 inhibitor.
  Osmotic nephropathy is an infrequent drug‑induced complication characterized by vacuolization of renal tubular cells secondary to lysosomal uptake, which increases osmotic pressure within the proximal tubule. This lesion pattern has been linked to admin…
  pubmed Castellanos-de la Hoz J, Molano-Triviño A, González-García YF, Espinosa Saltaren LM 等 2026 Feb 14 置信度 0.82
• [Expert consensus on adverse reaction management of PAM pathway inhibitors in breast cancer (2026 edition)].
  The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathway (PAM pathway) is a crucial signaling network regulating cell proliferation, survival, and metabolism, which plays a central role in the patho…
  pubmed Cancer Drug Clinical Research Committee of China Anti-Cancer Association, Standard Construction Committee of China Anti-Cancer Association 2026 Feb 23 置信度 0.82