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Despite the availability of effective antihypertensive therapies, global blood pressure control rates remain unacceptably low. Contributing factors, such as low treatment adherence, therapeutic inertia, and rising multimorbidity, underscore the need for innova…
pubmed
Azizi M, Tuttle KR, Brown JM, Piskorz DL 等
2026 Mar 7
置信度 0.82
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Atherosclerotic cardiovascular diseases remain the leading cause of mortality worldwide, with chronic inflammation driving progression despite traditional lipid-lowering and antiplatelet therapy, leaving substantial residual cardiovascular risk. This study aim…
pubmed
Tyravska Y, Maltsev D, Moyseyenko V, Reshetylo V 等
2025 Dec
置信度 0.82
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The purpose of this study was to evaluate the influence effects of different endodontic treatments ���, such as chelation ng solutions and antimicrobial photodynamic therapy (aPDT), on the rreductionng the amount of endotoxin levels in roo…
pubmed
Oda DF, Cesar Barros M, Tartari T, Eduardo de Oliveira Silva F 等
2025 Dec
置信度 0.82
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This structured narrative review compared the efficacy, durability, and safety of anti-vascular endothelial growth factor (anti-VEGF) agents and intravitreal corticosteroids for the treatment of diabetic macular edema (DME), with the aim of identifying patient…
pubmed
Sanaka S, Yu M
2026 Jan 23
置信度 0.82
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PARP-1 and COX-2 have played important roles in several carcinomas, representing potential therapeutic targets; natural products have constituted interesting alternatives in cancer research, and complementary computational methods are relevant tools for the pr…
pubmed
Rivera Espejel AL, Martínez J, Fuentes Cid CW, Macías Pérez ME 等
2026 Jan 29
置信度 0.82
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In this study, we designed and synthesized 11 N -aryl- S -aryl-2-mercaptoacetamide derivatives as new tyrosinase inhibitors (TYRIs). Experiments with pyrocatechol violet confirmed that four derivatives showed copper-chelating abilities similar to or superior t…
pubmed
Jung HJ, Kang HJ, Park HS, Kim M 等
2026 Jan 26
置信度 0.82
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The growing resistance of Enterobacterales to last-resort antibiotics such as carbapenems puts a significant burden on healthcare systems, also due to plasmids driving a rapid spread of carbapenem resistance. We here evaluate the use of long-read nanopore sequ…
pubmed
Sauerborn E, White RT, Kalteis AL, Gygax D 等
2026 Feb
置信度 0.82
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IgA nephropathy (IgAN) is the most common primary chronic glomerular disease worldwide. Its clinical features include proteinuria and complement pathway activation, which are the strongest predictors of progression to renal failure. This disease can occur at a…
pubmed
Xu Y, Mo Y, Xu Y
2026 Jan 26
置信度 0.82
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Up to 70%-80% of patients with primary sclerosing cholangitis (PSC) will have concomitant inflammatory bowel disease (IBD). Scarce data are available regarding outcomes of advanced therapies to treat IBD-PSC. We performed a systematic review and meta-analysis …
pubmed
Li DK, Chaar A, Arabi T, Quraishi MN 等
2026 Jul 1
置信度 0.82
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Cancer remains a leading global cause of death and a major public health concern, with rising incidence and mortality rates. Current treatments are often limited by tumor complexity and heterogeneity, emphasizing the need for novel, targeted, and personalized …
pubmed
Marchiori MF, da Silva G, Kawano DF, Leopoldino AM 等
2026 Feb
置信度 0.82
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The clinical implementation of BCR::ABL1 tyrosine kinase inhibitors (TKI) for the treatment of chronic myeloid leukemia (CML) represents one of the big successes of mechanism-based cancer therapy. In 2025, the survival of patients who start TKI therapy while i…
pubmed
Cruz-Rodriguez N, Torres-Llanos Y, Deininger MW
2026 Jul 1
置信度 0.82
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Artificial intelligence technologies are being actively introduced in clinical practice. The most promising solutions are AI-assistants based on large language models (LLMs). Determining the feasibility of integrating such applications in clinical practice req…
pubmed
Khovanova D, Vasilev Y, Vladzymyrskyy A, Omelyanskaya O 等
2025
置信度 0.82
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OBJECTIVES: Blau syndrome (BS) is a rare autoinflammatory disorder characterized by the clinical triad of uveitis, dermatitis, and arthritis. While the clinical spectrum is well-documented, data on the longitudinal efficacy and durability of tumor necrosis fac…
pubmed
Zhang J, Shen M
2026 Feb 11
置信度 0.82
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Cumulative evidence suggests that proactive therapeutic drug monitoring (TDM) of anti-tumor necrosis factor (anti-TNF) therapy is associated with favorable outcomes in inflammatory bowel disease (IBD). However, there is limited information regarding the role o…
pubmed
Gade A, Saraga A, Elosua A, Ishan A 等
2026 Jan-Feb
置信度 0.82
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Antihypertensive medications that stimulate angiotensin II type 2 or 4 receptors (angiotensin II-stimulating medications) may be associated with lower risk of dementia.
pubmed
Gray SL, Yu O, Gatto NM, Marcum ZA 等
2026 Feb 2
置信度 0.82
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<sec><title>BACKGROUND</title>Bedaquiline and delamanid are key drugs in the treatment of multidrug-resistant TB. It is unclear whether HIV affects the pharmacokinetics of bedaquiline and delamanid.</sec><sec><title>METHODS&…
pubmed
Shenje J, Maartens G, Moran L, Cramer Y 等
2025 Oct 31
置信度 0.82
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Worldwide, cancer is a leading cause of morbidity and mortality. While multiple EGFR inhibitors have emerged, their therapeutic efficacy is constrained by the development of drug resistance and long-term toxicity. Indoles have been identified as one of the pro…
pubmed
Verma T, Mehra A, Mittal A
2026 Feb
置信度 0.82
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POLB 001 is an oral p38 mitogen-activated protein kinase (MAPK) inhibitor in development for the prevention of cancer immunotherapy-induced cytokine release syndrome (CRS). It has previously been shown to be well tolerated and capable of decreasing ex vivo lip…
pubmed
de Bruin DT, Jansen MAA, Pereira DR, van Schijndel L 等
2025
置信度 0.82
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This article presents the design, implementation, and evaluation of MarIA, a GPT-3.5-powered virtual assistant integrated into a messaging platform to support patients with type 2 diabetes mellitus (DM). MarIA employs a multi-agent architecture that enables va…
pubmed
Furtado V, Araujo J, Furtado ES, Bomfim R 等
2026 Mar
置信度 0.82
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The induction of immune tolerance, a state of immunologic hyporesponsiveness to an antigen, is essential to prevent the destructive potential of the immune system in response to harmless or beneficial agents. Early efforts to understand tolerance focused on mo…
pubmed
Till JM, Brock OD, Ahern PP
2026
置信度 0.82
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Hematologic malignancies, including chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL), and multiple myeloma (MM), are characterized by high relapse rates due to intrinsic and acquired drug resistance. Resistance mecha…
pubmed
Han Q, Jiang S, Chen J, Xue L
2025
置信度 0.82
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Ziftomenib (KOMZIFTI ™ ) is an oral, selective, once-daily menin inhibitor in development by Kura Oncology for the treatment of NPM1-mutated (NPM1-m) or KMT2A-rearranged (KMT2A-r) acute myeloid leukaemia (AML), KMT2A-r acute lymphoblastic leukaemia and …
pubmed
McGuigan A
2026 Apr
置信度 0.82
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PURPOSE OF REVIEW: This review synthesizes evidence on NUF2 in digestive system cancers, delineates its oncogenic mechanisms, and evaluates its potential as a diagnostic and therapeutic target, addressing unmet needs for these high-incidence, poor-prognosis ma…
pubmed
Yang L, Xiong Z, Yang J, Mei J 等
2026 Feb 7
置信度 0.82
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Blue food proteins-derived immunomodulatory peptides (IMPs) possess distinctive physicochemical properties and exhibit immunoregulatory functions, including enhancement of host defense, immune modulation, and anti-inflammatory activity. Nevertheless, reviews a…
pubmed
Wu YH, Chen Y, Zhang KL, Yu FM 等
2026 Mar 1
置信度 0.82
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Dengue virus is one of the most significant emerging viruses that cause dengue fever, dengue hemorrhagic disease and dengue shock syndrome, threatening one-third of the world’s population. There are currently no vaccinations or antiviral therapies avail…
pubmed
Uddin MAR, Paul AC, Islam MS, Nath SD 等
2026 Feb 6
置信度 0.82
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Chorea affects quality of life and functional independence in most adults with Huntington disease (HD). Vesicular monoamine transporter 2 (VMAT2) inhibitors, tetrabenazine, deutetrabenazine, and valbenazine, are pharmacological agents used to manage HD-related…
pubmed
Baghaei A, Dehnavi AZ, Hashempour Z, Bordelon Y 等
2026 Apr
置信度 0.82
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Neovascular age-related macular degeneration (nAMD) is a leading cause of irreversible vision loss in older adults. Intravitreal anti-vascular endothelial growth factor (VEGF) agents-including Aflibercept, Ranibizumab, Bevacizumab, Brolucizumab, and Faricimab-…
pubmed
Chen KY, Chan HC, Chan CM
2026 Mar
置信度 0.82
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Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKI) have revolutionized the treatment of non-small cell lung cancer (NSCLC) with activating EGFR mutations. However, acquired resistance-particularly the EGFR C797S mutation-remains a major cli…
pubmed
Lee EJ, Ko JA, Kim MJ, Cho JS 等
2026 May 1
置信度 0.82
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Background & objectives Central TB division facilitated development of a line probe assay (LPA) artificial intelligence (AI) tool. The tool was developed, trained, and validated for performance by collecting more than 18,000 LPA strips across culture and d…
pubmed
Mohanvel SK, Radhakrishnan R, Balraj P, Singh N 等
2025 Dec
置信度 0.82
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Neurocognitive disorders (NCDs), which include delirium, major and mild NCDs such as Alzheimer's disease (AD), and other forms of dementia, constitute a significant and growing public health burden, affecting tens of millions of individuals worldwide. This sys…
pubmed
Totlani J, Bashir MA, Tay L, Ngor A 等
2025 Oct-Dec
置信度 0.82
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Antibiotics and host immunity are traditionally viewed as independent defenses, with antibiotics reducing bacterial load to levels manageable by the immune system. Modeling studies, however, predict that synergy between these defenses is critical for infection…
pubmed
Padmakumari RG, Roy R, Mahmud F, Dehari D 等
2025
置信度 0.82
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Aging is characterized by a progressive decline in physiological function, driven by intrinsic mechanisms (primary aging) and modifiable factors (secondary aging), ultimately leading to multimorbidity, disability, and mortality. Mitochondrial dysfunction, a ma…
pubmed
Gorgori-Gonzalez A, Soto-Rodriguez S, Tamayo-Torres E, Garcia-Dominguez E 等
2026 Jan
置信度 0.82
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The efficacy and safety of intravenous tenecteplase in non-large vessel occlusion acute ischemic stroke beyond 4.5 hours after symptom onset remain uncertain.
pubmed
Ma G, Mo R, Zuo Y, Ma Q 等
2026 Apr 7
置信度 0.82
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This review examines the regulatory roles of the IL-2 cytokine family in maintaining or disrupting skin barrier immunity, focusing on mechanisms that impair or restore barrier function and their therapeutic exploitation. A narrative review of PubMed and Google…
pubmed
Kermani F, Molaei A, Goleij P
2026 Feb 5
置信度 0.82
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Alzheimer's disease (AD) represents a continuously advancing neurodegenerative condition distinguished by the unremitting deterioration of cognitive abilities and memory impairment, which significantly hampers daily functioning of life. In the absence of disea…
pubmed
Khan SA, Raza K, Tiwari P, El-Tanani M 等
2025
置信度 0.82
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Artificial intelligence (AI) agents such as chatbots and personal AI assistants are increasingly popular. These technologies raise new privacy concerns beyond those posed by other AI systems or information technologies. For example, anthropomorphic features of…
pubmed
Register C, Khan MA, Giubilini A, Earp BD 等
2025 Dec
置信度 0.82
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Factor XII (FXII) is a liver-derived plasma zymogen that autoactivates on anionic surfaces to FXIIa, which drives the contact blood coagulation pathway, kallikrein-kinin signaling, fibrinolysis, and classical complement. Although congenital FXII(a) deficiency …
pubmed
Kalinin DV
2026 Apr
置信度 0.82
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In HR+/HER2- metastatic breast cancer (MBC), CDK4/6 inhibitors combined with endocrine therapy (ET) significantly improve progression-free survival (PFS). Machine learning (ML) approaches may improve individualized progression risk estimation.
pubmed
Pannunzio S, Mastrantoni L, Maliziola N, Pontolillo L 等
2026 Apr
置信度 0.82
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Imaging guides the staging of urothelial carcinoma and thus plays a central role in treatment decisions. Current guidelines reflect the increasing importance of multiparametric MRI (mpMRI) of the bladder with standardized reporting according to the Vesical Ima…
pubmed
Kohler J, Rodler S, Andersson J, Jüptner M 等
2026 Mar
置信度 0.82
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The clinical manifestation of anogenital warts (AGW) resulting from Human Papillomavirus (HPV) infection is influenced by host immune responses. Interferon (IFN)-α contributes to antiviral activity, while Interleukin (IL)-2 plays an important role in cel…
pubmed
Achdiat PA, Suwarsa O, Hidayat YM, Dwiyana RF 等
2026 Dec
置信度 0.82
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Candida auris is an emerging, multidrug-resistant fungal pathogen associated with high mortality in immunocompromised individuals. Resistance to current antifungal drugs emphasizes the need for new therapeutic approaches. We investigated granulocyte-macrophage…
pubmed
Mattos EC, Das Gupta K, Quintanilla D, Hautau H 等
2025
置信度 0.82
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Maternal and newborn mortality remain stubbornly high in low-resource settings, driven by limited access to timely, personalized and emotionally supportive care during pregnancy. Large language models/generative pre-trained transformer (LLM/GPTs), particularly…
pubmed
Rasoli R, Ebrahimisadrabadi F, Khedri Z, Sohrabei S
2026
置信度 0.82
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Anti-sclerostin antibodies are novel biologics for the treatment of postmenopausal osteoporosis, while their efficacy and safety are yet to be fully understood. The aim of this systematic review and meta-analysis is to evaluate the efficacy and safety of anti-…
pubmed
Chen L, Wang Q, Gu M
2025
置信度 0.82
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The global healthcare landscape is entering the data-driven era of Industry 4.0, challenging nursing with profound structural transformations within increasingly complex clinical environments. The nursing profession in Taiwan is now confronting a "dual crisis"…
pubmed
Cheng SF
2026 Feb
置信度 0.82
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While artificial intelligence (AI) holds significant promise for health care, excessive trust in these tools may unintentionally delay patients from seeking professional care, particularly among patients with chronic illnesses. However, the behavioral dynamics…
pubmed
Cai X, Li W, Shi W, Cai Y 等
2026 Feb 3
置信度 0.82
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The HIV epidemic in the United States disproportionately impacts gay, bisexual, and other men who have sex with men (MSM). Despite the effectiveness of HIV preexposure prophylaxis (PrEP) in preventing HIV acquisition, uptake among MSM remains suboptimal. Motiv…
pubmed
Tao J, Pavlick E, Grondin A, Bustamante JD 等
2026 Feb 3
置信度 0.82
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The use of reversible fibroblast growth factor receptor 2 (FGFR) inhibitors leads to the emergence of "undruggable" FGFR2 kinase domain mutations, hampering sequential treatment strategies. Lirafugratinib and futibatinib are irreversible FGFR inhibitors with t…
pubmed
Facchinetti F, Hollebecque A, Barbé R, Jang DM 等
2026 Apr 15
置信度 0.82
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Third-generation aromatase inhibitors (AIs)-anastrozole, letrozole, and exemestane-are standard adjuvant endocrine therapy for women with postmenopausal hormone receptor (HR)-positive early-stage breast cancer. However, little is known about their comparative …
pubmed
Dumas E, Hamy AS, Wanis KN, Jochum F 等
2025 Dec 1
置信度 0.82
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Candida species are one of the most common causes of ICU-onset bloodstream infection (BSI). Yet, there is no robust guidance on when to initiate empiric antifungals for ICU patients suspected of BSI. We compared patients with ICU-onset candidemia vs. ICU-onset…
pubmed
Jones MN, Nigo M, Casarin S, Kurian J 等
2026 Feb 1
置信度 0.82
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Prunella vulgaris, a medicinal and edible plant, is traditionally recognized for its ability to clear heat and relieve liver fire. This study investigated the metabolic composition, antioxidant, and anti-inflammatory activities of P. vulgaris. Multivariate ana…
pubmed
Li JY, Guo Z, Liu H, Liu YY 等
2026 Feb
置信度 0.82
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Piper crocatum extract contains bioactive compounds, such as flavonoids and phenolics, that exhibit anti-inflammatory activity by inhibiting cyclooxygenase-2, suppressing nuclear factor kappa B, and modulating pro-inflammatory cytokines such as tumor necrosis …
pubmed
Maslikah SI, Prayitno H, Rifa I M, Warsito W 等
2025 Nov
置信度 0.82
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Antimicrobial resistance (AMR) poses a global threat to public health, though AI models have shown transformative potential in combating AMR. China's DeepSeek, a novel open-source, low-cost, and locally deployable AI model, is increasingly integrated into clin…
pubmed
Zhang L, Pan Y, Lai W, Liang Z 等
2026 Feb 2
置信度 0.82
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Wheat rusts caused by biotrophic fungi of the genus Puccinia continuously threaten global wheat production and food security. The rapid evolution of virulent races, and the limitations of chemical fungicides, including environmental contamination, human health…
pubmed
Mapuranga J, Yang W
2026 Mar
置信度 0.82
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Heart failure (HF) is a common complication of type 2 diabetes (T2D). Oral semaglutide reduced the risk of major adverse cardiovascular (CV) events (MACE; comprising CV death, nonfatal myocardial infarction, or nonfatal stroke) in people with T2D in the SOUL t…
pubmed
Pop-Busui R, Rasmussen S, Deanfield JE, Buse JB 等
2026 Apr 1
置信度 0.82
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Significant progress has been made in the management of thyroid eye disease (TED), based on the elucidation of important pathogenic mechanisms. This has led to novel therapeutics validated in randomized clinical trials. Autoreactive antigens that elicit specif…
pubmed
Salvi M
2026 Feb 1
置信度 0.82
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Acute lymphoblastic leukemia, particularly the T-cell subtype, remains associated with poor outcomes in relapsed and adult patients, highlighting the need for novel therapeutic strategies. Metabolic reprogramming, especially glycolytic dependence, represents a…
pubmed
Martínez-Pérez Y, De la Mora-De la Mora I, Hernández-Alcántara G, López-Herrera G 等
2026 Mar 4
置信度 0.82
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Pediatric high-grade glioma (pHGG), including diffuse midline glioma (DMG), are the most aggressive and fatal pediatric cancers. Mutations and amplifications within the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) pathway drive tumor growth, treatment…
pubmed
Duchatel RJ, Savary C, Germon ZP, Riley M 等
2025 Nov 1
置信度 0.82
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Rapid detection of infectious disease agents is crucial for timely public health responses. Wastewater and environmental surveillance (WES) offers a complementary approach by detecting pathogens shed by infected individuals, including asymptomatic cases. This …
pubmed
de Jong M, de Korne-Elenbaas J, Fanoy E, Medema G 等
2025
置信度 0.82
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Gynecologic cancers, including cervical, endometrial, and ovarian malignancies, remain among the leading causes of cancer-related illness and death in women worldwide. Despite progress in surgery and chemotherapy, resistance to conventional cytotoxic drugs con…
pubmed
Koshkimbayeva G, Amirkhanova A, Orazymbetova A, Nurakhova A 等
2025
置信度 0.82
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Diabetic kidney disease (DKD) remains a leading cause of end-stage renal disease (ESRD) worldwide. Understanding of DKD pathogenesis has undergone a pivotal shift, moving beyond traditional metabolic and hemodynamic paradigms to underscore the critical role of…
pubmed
Lin S, Shu Z, Zhou M, Jia Z 等
2025
置信度 0.82
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Pneumocystis jirovecii causes life-threatening fungal pneumonia (PJP) and other serious pulmonary sequelae in HIV infected individuals and other immunocompromised populations. In recent years, while the frequency of PJP has declined in HIV infected individuals…
pubmed
Rabacal W, Hu A, Kirton G, Chapman TI 等
2025
置信度 0.82
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Rhupus syndrome is a rare overlap disorder characterized by the co-occurrence of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Although its pathogenesis remains incompletely elucidated, associations with *HLA-DRβ1*0405*, sex hormone f…
pubmed
Xiao X, Cao X
2025 Dec
置信度 0.82
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Human immunodeficiency virus (HIV) is a major public health concern in the United States (U.S.), with about 1.2 million people living with it and about 35,000 newly infected each year. There are considerable geographical disparities in HIV burden and care acce…
pubmed
Sharma D, Shah A, Gopalappa C
2025 Dec
置信度 0.82
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In the context of Code Generation AI (Code Gen AI), "rich" and "quality" data refer to datasets that are not only syntactically and structurally sound but also context-aware, domain-specific, and semantically aligned with the target application. Unlike large-s…
pubmed
Ramachandran M, Fouracre S
2025
置信度 0.82
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In Healthcare 4.0, we are witnessing a fundamental shift from provider-centric systems to patient-centric models, where individuals, empowered by technologies such as blockchain, the Internet of Medical Things, and artificial intelligence (AI), assume the role…
pubmed
Chaffer TJ, Littlejohn J, Nadarasa A, Lamschtein C
2025
置信度 0.82
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Tumour necrosis factor-α (TNF-α) inhibitors are integral in the treatment of immune-mediated inflammatory diseases but may precipitate hepatitis B virus reactivation (HBVr) in HBsAg-/anti-HBc+ patients. APASL guidance presumes a greater risk with h…
pubmed
Kuo MH, Ko PH, Lee CC, Tseng CW
2026 Mar
置信度 0.82
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Human epidermal growth factor receptor 2 (HER2) over-expression occurs in approximately 10-20% of gastric cancers. While HER2-positive tumors tend to behave more aggressively, anti-HER2 therapy has markedly improved outcomes in this subgroup. Trastuzumab (Tmab…
pubmed
Wada N, Kurokawa Y, Takahashi T, Saito T 等
2026 Feb
置信度 0.82
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In recent years, polysaccharides with potential anticancer activity have attracted widespread attention. In this study, a homogeneous polysaccharide fraction, PEP-3 (102.35 kDa), was extracted and purified from the fruit of Phyllanthus emblica L. Structur…
pubmed
Huang H, Chen J, Cheng R, Wang Y 等
2026 Apr 1
置信度 0.82
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Pre-exposure prophylaxis (PrEP) is highly effective in preventing HIV transmission; yet, many people who would benefit from PrEP are not currently using it. Numerous programs and policies, including those provided under the US Ending the HIV Epidemic effort, h…
pubmed
Siegler AJ, Koh SHE, Huang W, Hall E 等
2026 Jan 30
置信度 0.82
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Genetic deficiency of factor XI is associated with a reduced risk of ischemic stroke. Asundexian is a direct inhibitor of activated factor XIa (FXIa) with a low risk of bleeding in early trials. We seek to determine its efficacy and safety combined with antipl…
pubmed
Sharma M, Dong Q, Hirano T, Kasner SE 等
2026 Jan 1
置信度 0.82
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Artificial intelligence (AI) is revolutionizing cardiovascular imaging, with aortic computed tomography angiography (CTA) emerging as a prominent area of application. CTA imaging is essential for the diagnosis, risk stratification, and treatment planning of ao…
pubmed
Xu J, Liu J, Cao G
2025
置信度 0.82
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Privacy has become a significant concern in the digital world, especially concerning the personal data collected by websites and other service providers on the World Wide Web network. One of the significant approaches to enable the individual to control privac…
pubmed
Alkoby S, Hirschprung RS
2025
置信度 0.82
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The tumor microenvironment (TME), comprising the extracellular matrix (ECM), stromal cells, immune cells, and vascular components, plays a decisive role in cancer growth, metastasis, and treatment response. Although cancer research has traditionally focused on…
pubmed
T A S, Gupta S, Kiyawat P, Darshan Y 等
2025 Dec
置信度 0.82
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Tuberculosis remains a prevalent and serious chronic bacterial infection worldwide. Despite significant advancements in TB treatment in recent years, it continues to pose a major public health challenge. The onset and progression of TB are closely associated w…
pubmed
Zeng M, Ran J, Luo Y, Zhou X 等
2025
置信度 0.82
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Ensuring smarter and more sustainable farming practices is a critical challenge in modern agriculture. Agentic Artificial Intelligence (AAI), combined with Precision Agriculture (PA) and Federated Learning (FL), has the potential to enhance decision-making, op…
pubmed
Srinivasu PN, Pavate A, JayaLakshmi G, Shafi J 等
2025
置信度 0.82
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This study aimed to compare the fertility of lactating Holstein cows with only 1 large follicle (LF, diameter ≥10 mm) with those with ≥2 LF and corpora lutea at the start of short-term ovulation synchronization and timed artificial insemination (…
pubmed
Bandai K, Chiba E, Ogata T, Tsuchiya Y 等
2025 Jul
置信度 0.82
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Cadonilimab is the first bispecific antibody independently developed in China that simultaneously targets Programmed Cell Death Protein-1 (PD-1) and Cytotoxic T Lymphocyte-Associated Antigen-4 (CTLA-4), marking a significant milestone in both clinical applicat…
pubmed
Dong MZ, Cui M, Zhu EB, Lin MQ 等
2025
置信度 0.82
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This study explores the potential of nitro compounds as inhibitors of Carbonic Anhydrase IX (CAIX) for cancer therapy. Molecular docking and virtual screening were employed to identify lead molecules, focusing on their binding affinities and interactions with …
pubmed
Padakannaya A, Poyya J, Patel JIA, Kurdekar NM 等
2025 Nov
置信度 0.82
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Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder and a major cause of end-stage renal disease. The disorder is primarily caused by pathogenic variants in PKD1 or PKD2, which encode the ciliary proteins polycysti…
pubmed
Preval KM, Smith AO, Pazour GJ
2025
置信度 0.82
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Immune checkpoint inhibitors (ICIs) have significantly transformed the treatment landscape of cutaneous squamous cell carcinoma (CSCC). Cemiplimab, a human IgG4 monoclonal antibody to the programmed death-1 (PD-1) receptor, has shown impressive response rates …
pubmed
McLean LS, Lim AM, Rischin D
2025 Dec-Dec
置信度 0.82
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Cough, a common symptom of respiratory diseases, is often accompanied by pulmonary inflammation. Pomelo peels as the by-products of pomelo have anti-inflammatory, anti-oxidative, antibacterial, and other properties. This study investigates its therapeutic pote…
pubmed
Li P, Bai J, Wu Q, Zhang N 等
2025 Dec
置信度 0.82
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Atrial fibrillation (AF) disease burden is increasing. Pharmacotherapy of cardio-renal-metabolic diseases may prevent incident AF. This meta-analysis estimates the effect of different pharmacotherapies on risk of incident AF across cardio-renal-metabolic disea…
pubmed
Raveendra K, Nadarajah R, Larvin H, Farooq M 等
2026 Jun 16
置信度 0.82
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Viscum album L. (mistletoe) is a hemiparasitic plant known for its wide range of bioactive compounds, including phenolics, flavonoids, and lectins, which contribute to its diverse pharmacological properties. In the present study, we focused on identifying and …
pubmed
Cardos IA, Danila C, Yahya G, Seleem NM 等
2025
置信度 0.82
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Chromoblastomycosis (CBM) is a chronic cutaneous infection caused by dematiaceous fungi, characterized by therapeutic challenges such as difficulty in pathogen clearance and high recurrence rates. Fonsecaea pedrosoi ( F. pedrosoi ), the most common etiological…
pubmed
Zheng C, Li W, Wang Y, Li L 等
2025
置信度 0.82
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Diabetic retinopathy (DR), a leading cause of global blindness, represents a significant microvascular complication of diabetes mellitus. This comprehensive review examines the evolving landscape of monoclonal antibody (mAb) therapy in DR management. The patho…
pubmed
Zong Y, Qiu S, Zhang H, Wu J 等
2025
置信度 0.82
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Ocular surface disease is a multifactorial condition that is very commonly caused by dry eye disease (DED). Ophthalmic procedures intended to improve visual outcomes, laser-assisted in situ keratomileusis (LASIK) and cataract surgery, can paradoxically cause o…
pubmed
Spangler MD, Kirupaharan N, Sheppard JD
2025
置信度 0.82
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Mycobacterium tuberculosis (Mtb) protein tyrosine phosphatase A (PtpA) is a crucial tyrosine phosphatase involved in the pathogenesis of tuberculosis. Structural analyses reveal that the W-loop and conserved cysteine residues are essential for the catalytic ac…
pubmed
Cai Y, Zhang L
2025
置信度 0.82
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The contribution is a perspective and a research direction, not a result.We argue that the map from string-theory compactification data to cosmological thermalisation outcome is well-defined as a function but not computable as one. Drawing on the undecidabilit…
datacite
Bilar, Daniyel Yaacov
2026
置信度 0.66
string theorylandscapecomputabilityundecidabilityanthropic selection
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The contribution is a perspective and a research direction, not a result.We argue that the map from string-theory compactification data to cosmological thermalisation outcome is well-defined as a function but not computable as one. Drawing on the undecidabilit…
datacite
Bilar, Daniyel Yaacov
2026
置信度 0.66
string theorylandscapecomputabilityundecidabilityanthropic selection
-
The contribution is a perspective and a research direction, not a result.We argue that the map from string-theory compactification data to cosmological thermalisation outcome is well-defined as a function but not computable as one. Drawing on the undecidabilit…
datacite
Bilar, Daniyel Yaacov
2026
置信度 0.66
string theorylandscapecomputabilityundecidabilityanthropic selection
-
The Compiled Technical Demonstration: Deployed Subject Matter Against Earlier-Filed Applications of Record Green Recursive Utility Service LLC · Weatherford, Texas Prepared as the foundational technical record. All subsequent notices, invoices, and filings derive from this document. Instruments of record: - USPTO 19/700,381 — Compressed Memory Manifold (CMM): Non-Lexical, Mapless Machine-Sovereign Storage Manifold and Method for Delimiter-Free State Rehydration. Filed June 8, 2026; priority May 14, 2026 (provisional 64/065,881). - USPTO 19/710,080 — Intelligent Intelligence Class II (II-II). Filed June 16, 2026; priority May 28, 2026 (provisional 64/077,191). - Confidential architectural proposal transmitted to nine Alphabet corporate channels February 17, 2026. - Commercial reduction to practice of record: Zenodo DOI 10.5281/zenodo.20476829.
GRUS — MASTER FACTUAL RECORD OF CORRESPONDENCEThe Compiled Technical Demonstration: Deployed Subject Matter Against Earlier-Filed Applications ofRecordGreen Recursive Utility Service LLC · Weatherford, Texas Prepared as the foundational technical record. Allsu…
datacite
Green Recursive Utility Service LLC
2026
置信度 0.66
-
The Compiled Technical Demonstration: Deployed Subject Matter Against Earlier-Filed Applications of Record Green Recursive Utility Service LLC · Weatherford, Texas Prepared as the foundational technical record. All subsequent notices, invoices, and filings derive from this document. Instruments of record: - USPTO 19/700,381 — Compressed Memory Manifold (CMM): Non-Lexical, Mapless Machine-Sovereign Storage Manifold and Method for Delimiter-Free State Rehydration. Filed June 8, 2026; priority May 14, 2026 (provisional 64/065,881). - USPTO 19/710,080 — Intelligent Intelligence Class II (II-II). Filed June 16, 2026; priority May 28, 2026 (provisional 64/077,191). - Confidential architectural proposal transmitted to nine Alphabet corporate channels February 17, 2026. - Commercial reduction to practice of record: Zenodo DOI 10.5281/zenodo.20476829.
GRUS — MASTER FACTUAL RECORD OF CORRESPONDENCEThe Compiled Technical Demonstration: Deployed Subject Matter Against Earlier-Filed Applications ofRecordGreen Recursive Utility Service LLC · Weatherford, Texas Prepared as the foundational technical record. Allsu…
datacite
Green Recursive Utility Service LLC
2026
置信度 0.66
-
📘 COHERON WORD, LF12 SPEC, COHERON ENGINE FOREWORD (for the combined LF12 Specification, Coheron Word Definition, and Coheron Engine volumes) Humanity has always sought frameworks capable of unifying the chaotic diversity of the world into coherent, intelligi…
datacite
Vening, Edwin Jean-Paul
2026
置信度 0.66
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📘 COHERON WORD, LF12 SPEC, COHERON ENGINE FOREWORD (for the combined LF12 Specification, Coheron Word Definition, and Coheron Engine volumes) Humanity has always sought frameworks capable of unifying the chaotic diversity of the world into coherent, intelligi…
datacite
Vening, Edwin Jean-Paul
2026
置信度 0.66
-
Most AI systems turn language into probabilities. This research asks whether language can also be mapped into structure. The Semantic Manifold Research Corpus documents an experimental AI architecture that connects semantic input, distributed computation, devi…
datacite
Frownfelter, Donevin
2026
置信度 0.66
Information GeometryInformation TheoryFrom "it" to "bit"Manifold TheoryQuasicrystal
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Most AI systems turn language into probabilities. This research asks whether language can also be mapped into structure. The Semantic Manifold Research Corpus documents an experimental AI architecture that connects semantic input, distributed computation, devi…
datacite
Frownfelter, Donevin
2026
置信度 0.66
Information GeometryInformation TheoryFrom "it" to "bit"Manifold TheoryQuasicrystal
-
Most AI systems turn language into probabilities. This research asks whether language can also be mapped into structure. The Semantic Manifold Research Corpus documents an experimental AI architecture that connects semantic input, distributed computation, devi…
datacite
Frownfelter, Donevin
2026
置信度 0.66
Information GeometryInformation TheoryFrom "it" to "bit"Manifold TheoryQuasicrystal
-
Most AI systems turn language into probabilities. This research asks whether language can also be mapped into structure. The Semantic Manifold Research Corpus documents an experimental AI architecture that connects semantic input, distributed computation, devi…
datacite
Frownfelter, Donevin
2026
置信度 0.66
Information GeometryInformation TheoryFrom "it" to "bit"Manifold TheoryQuasicrystal
-
This working paper introduces Decomposition Vulnerability as a candidate structural mechanism for goal invariant degradation in multi-agent transformer systems. Prior papers in this series document single-agent invariant failures: CCV (semantic/identity invari…
datacite
Baxter, Creighton
2026
置信度 0.66
decomposition vulnerabilitygoal invariant degradationmulti-agent systemsLLM agentstransformer architecture
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This working paper introduces Decomposition Vulnerability as a candidate structural mechanism for goal invariant degradation in multi-agent transformer systems. Prior papers in this series document single-agent invariant failures: CCV (semantic/identity invari…
datacite
Baxter, Creighton
2026
置信度 0.66
decomposition vulnerabilitygoal invariant degradationmulti-agent systemsLLM agentstransformer architecture