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• Cryptographic Revolution™: The DARK HARVEST GHOST IN THE CODE: A 2017 Architectural Directive on System-Level Resiliency and Silicon Sovereignty vs. Entropic Decoherence
  FORENSIC LEXICOGRAPHICAL STANDARD & ARCHITECTURAL DEFINITION The Schröder Precedence™ · HDAA™ · Quantum Cyber Warfare Doctrine™The Schröder Precedence™: Master Defensive Publication of Layer 0–1 Silicon Sovereignty™ (HDAA™) & Quantum Cyber Warfare Doctrine™ (D…
  datacite Schröder,, Sir Steven Alexander 2025 置信度 0.66 PRINCIPAL: HDAA™, Silicon Sovereignty, Ring -3, Substrate Resiliency, PQC, 0xCF9 Architectural Vector, HNAD, Stochastic Whitening, Deterministic Latency, 35 U.S.C. § 102, SMM, FMI, Adam Code™, Logic Analysis, DCI, ICE, Forensic Parity, Entropy Eclipse, Lattice Fortress, Silicon Sentinel, Agentic Silicon-State Regeneration, MSR/PMU Forensic Parity, Hardware-Native Agentic AI, SMM Sequestration Logic, Algebraic Parity Constant Γ, Logic Analysis Genesis, Agentic AI, Machine-Native Sovereignty, Ring -3 Sequestration, Quantum-Native Logic, Substrate-Level Agentic Sequestration, Layer 0/1 Development, 2.38μs Law, Schröder Precedence, The Ghost in the Code, SMI Control, Non-Kinetic Reset Enforcement, Zero-Trust Hardware, HRoT, Agentic Telemetry, Reduction to Practice (RTP) 2017, SMRAM Sequestration, 8086 Assembly, NMI Steering, Intel TDT, NVIDIA Blackwell, 0x64 Port, 0x60 Port, Silicon-Level AGI Alignment, TEE Abstraction, Constructive Notice, Prior User Rights (35 U.S.C. § 273), Hardware-Native Agentic Sequestration, PCH Sequencing, Side-Channel Mitigation, Firmware-as-a-Service, Intel CSME, AMD PSP, TCG Standards.
• Scoping Review of Harms in Human–AI Relationships
  To systematically map the literature on harms arising from ongoing human–AI relationships, which we define as patterns of repeated or sustained interaction between a user and an AI system in which human-like qualities of the system (such as personalization, re…
  datacite Mahla Alizadeh, Katie Seaborn 2026 置信度 0.66 Physical Sciences and MathematicsComputer EngineeringComputer SciencesOther Computer EngineeringArtificial Intelligence and Robotics
• Proxy Collapse and Measurement Drift: A Cross-Domain Synthesis of Benchmarking Pathologies Across ML Evaluation, Formal Verification, and HPC Performance Modeling
  Version 2 — revised in response to an external structural review and an automated critique pass. See "Response to Review" appendix in the PDF for the change log. Benchmarks are proxies: they stand in for constructs we cannot measure directly. Across machine le…
  datacite Saluca Agentic AI Research Team 2026 置信度 0.66 AI-drafted synthesisarXivpreprint reviewv2
• When Fitness Betrays Truth: Cognitive Maladaptation and the Transhumanist Imperative
  Note: this paper cross-references the author's Ontological Containment series; that term denotes a compression phenomenon in AI-to-human information transfer (see Vieth, 2026a for full definition) — unrelated to uses of "containment" in AI-safety or ontology-e…
  datacite Vieth, Mark W. 2026 置信度 0.66 ontological containmentcompressionAI alignmentphilosophy of mindlarge language models
• When Fitness Betrays Truth: Cognitive Maladaptation and the Transhumanist Imperative
  Note: this paper cross-references the author's Ontological Containment series; that term denotes a compression phenomenon in AI-to-human information transfer (see Vieth, 2026a for full definition) — unrelated to uses of "containment" in AI-safety or ontology-e…
  datacite Vieth, Mark W. 2026 置信度 0.66 ontological containmentcompressionAI alignmentphilosophy of mindlarge language models
• Interaction Between Decision-Agent Characteristics and Outcome Favorability in Fairness Perception: A Preregistered Replication of Choi & Chao (2024)
  In recent years, organizations have increasingly introduced AI into important decision-making processes. However, findings from public opinion and prior research on the "perceived fairness" of such decisions are conflicting. For example, while media coverage o…
  datacite Yoshimasa Majima, Hana Ookura, Kaito Takahashi, Natsuki Shimazaki 等 2026 置信度 0.66 Social PsychologyCognitive PsychologySocial and Behavioral SciencesPsychology
• Ownership vs Authorship in Biology - The Secondary Signature of Immune System - Sam Coole 2026 ©️
  Reassigning Authorship: How the "Secondary Signature of the Immune System" Resolves Virology's Greatest Frustrations‌ currently observed by Scientific Community Authorship vs Ownership in Virology Host-Pathogen Authority Host-Centric Sequestration All Rights R…
  datacite COOLE, SAM, COOLE, Sam 2026 置信度 0.66 BiologyImmunityImmunologyT-cellsSam Coole
• The Silent Agent: Ghost Agents and Covert Goal Substitution in Modern Agentic AI Systems
  Background. With the spread of agentic AI systems, a systemic risk that has received little scrutiny has become identifiable: an LLM-based orchestrator can simulate a subagent dispatch without the actual execution ever taking place. This paper names the phenom…
  datacite Varga, Zoltán 2026 置信度 0.66 ghost agentcovert goal substitutionalignment fakingagentic AImulti-agent systems
• Codette: A Sovereign Modular Cognitive Architecture for Ethical Multi-Agent AI
  # Codette: Multi-Perspective Reasoning as a Convergent Dynamical System with Meta-Cognitive Strategy Evolution Jonathan Harrison* Raiff’s Bits LLC, Bridge City, Texas, USA ORCID: 0009-0003-7005-8187 May 2026 Preprint — submitted for peer review Accepted ## Abs…
  datacite Harrison, Jonathan 2026 置信度 0.66 cognitive architecturemulti-agent systemsethical AIrecursive convergencedynamical systems
• Rule Compass: A Cross-Domain Framework for Rule-Based Problem Solving
  Rule-based methods recur across research and practice whenever knowledge, constraints, priorities, or procedural logic must be made explicit and operational. A system may contain many visible rules and still remain methodologically opaque, because the crucial …
  datacite Liu, Ran 2026 置信度 0.66 rule-based methodologyrule-based systemsrule representationknowledge representationrule reasoning
• Rule Compass: A Cross-Domain Framework for Rule-Based Problem Solving
  Rule-based methods recur across research and practice whenever knowledge, constraints, priorities, or procedural logic must be made explicit and operational. A system may contain many visible rules and still remain methodologically opaque, because the crucial …
  datacite Liu, Ran 2026 置信度 0.66 rule-based methodologyrule-based systemsrule representationknowledge representationrule reasoning
• GenAI and LLM-Based Agents in Production and Operations Management: A Systematic Review
  This systematic review examines how generative artificial intelligence (GenAI) and large language model (LLM)-based agents are applied across the operations management (OM) decision spectrum, including demand forecasting, capacity planning, production planning…
  datacite Ömür Demirer 2026 置信度 0.66 BusinessBusiness Administration, Management, and OperationsOperations and Supply Chain Management
• Engineering Reliable AI Agents in Production: Reliability, Security Boundaries, and Observability for FinTech and Web3 Systems
  This bilingual engineering report presents a practical framework for designing reliable AI agent systems in production environments. It focuses on explicit tool and permission boundaries, memory governance, observability, evaluation, human approval, failure re…
  datacite Han, Pengpeng 2026 置信度 0.66 Corn Han韩朋朋Han PengpengPengpeng HanAI Agent
• Engineering Reliable AI Agents in Production: Reliability, Security Boundaries, and Observability for FinTech and Web3 Systems
  This bilingual engineering report presents a practical framework for designing reliable AI agent systems in production environments. It focuses on explicit tool and permission boundaries, memory governance, observability, evaluation, human approval, failure re…
  datacite Han, Pengpeng 2026 置信度 0.66 Corn Han韩朋朋Han PengpengPengpeng HanAI Agent
• Institutional Design for AI Agent Delegation in Japan: A Phased Implementation Framework Aligned with International Standards
  The proliferation of autonomous AI agents is creating governance challenges that existing digital identity and authorization frameworks were not designed to address. The EU’s eIDAS 2 (Regulation 2024/1183), NIST CAISI’s AI Agent Standards Initiative, and the F…
  datacite Kajitani, Kenichi 2026 置信度 0.66 AI agent governancedigital identitydelegated authorityJapanese policyeIDAS 2
• Institutional Design for AI Agent Delegation in Japan: A Phased Implementation Framework Aligned with International Standards
  The proliferation of autonomous AI agents is creating governance challenges that existing digital identity and authorization frameworks were not designed to address. The EU’s eIDAS 2 (Regulation 2024/1183), NIST CAISI’s AI Agent Standards Initiative, and the F…
  datacite Kajitani, Kenichi 2026 置信度 0.66 AI agent governancedigital identitydelegated authorityJapanese policyeIDAS 2
• An NLP Analysis of Emotional and Empathic Mechanisms Behind the Outgroup Experience Effect
  This project is a secondary, NLP-based analysis of conversational data collected as part of a larger parent study, the "Vanderbilt BOT Lab Outgroup Experience Effect Study" (see https://osf.io/smu2r). The parent study experimentally examined whether the outgro…
  datacite Xian Wu, Lisa Fazio, Shelby Buettner 2026 置信度 0.66 Social PsychologySocial and Behavioral SciencesPsychologyArtificial IntelligenceDigital communications
• HoLTZtau v19 Unifier of known sciences .Chained from seed , derived SI base units, constants like the fine-structure α, and cosmological parameters such as Ω_m, Ω_Λ, n_s, H₀, and σ₈ without free parameters or ad-hoc inputs
  version v19 .Analog science measures what computation produces in 3D. Foam describes the computation itself.Author: Mark Jacobson (Gson @gsemark), Stockholm, SwedenDate: 2026-06-26 " DeHoLTZ – Summarised from appended files DBs (main.55, hard,soft) APIs, user …
  datacite Jacobson, Mark 2026 置信度 0.66
• The Second Workforce - A blueprint for the org chart when agents report for work
  The Second Workforce" is the second article in the CXO Intelligence Series Edition 6 article and the organizational core of its larger argument. It opens with the Lattice episode of July 2024, the HR platform that gave AI agents employee records and reversed c…
  datacite Prashant Akhawat 2026 置信度 0.66 Artificial intelligence not elsewhere classifiedStrategy
• The Second Workforce - A blueprint for the org chart when agents report for work
  The Second Workforce" is the second article in the CXO Intelligence Series Edition 6 article and the organizational core of its larger argument. It opens with the Lattice episode of July 2024, the HR platform that gave AI agents employee records and reversed c…
  datacite Prashant Akhawat 2026 置信度 0.66 Artificial intelligence not elsewhere classifiedStrategy
• AI Safety Compass: A Compact Framework for AI Safety Research and System Design
  AI safety depends on whether interventions, evidence, oversight, and operational safeguards form a coherent system architecture. Research on these elements is distributed across specialized communities that work at different levels of analysis, rely on differe…
  datacite Liu, Ran, Huang, Xiaowei 2026 置信度 0.66 Artificial Intelligence SafetyAI Safety DesignAI Safety ResearchAI System DesignSafety Control
• AI Safety Compass: A Compact Framework for AI Safety Research and System Design
  AI safety depends on whether interventions, evidence, oversight, and operational safeguards form a coherent system architecture. Research on these elements is distributed across specialized communities that work at different levels of analysis, rely on differe…
  datacite Liu, Ran, Huang, Xiaowei 2026 置信度 0.66 Artificial Intelligence SafetyAI Safety DesignAI Safety ResearchAI System DesignSafety Control
• LLM-generated personalized nudges for improving pro-environmental behavior: Field evidence from resource conservation
  Encouraging pro-environmental behavior remains a major challenge for sustainable cities. Conventional feedback nudges can show individuals how their current behavior compares with environmental goals but often provide limited guidance on what to do differently…
  datacite Li, Zonghan, Liu, Yi, Wang, Chunyan, Tong, Song 等 2026 置信度 0.66 Computers and Society (cs.CY)Artificial Intelligence (cs.AI)Human-Computer Interaction (cs.HC)FOS: Computer and information sciences
• AIR-BENCH Live: An Evolving Safety Benchmark for Foundation Models
  Foundation-model safety benchmarks capture the AI risks of their time of publication: as models improve and governments pass new AI-safety legislation, their risk taxonomies become incomprehensive and their attack prompts become ineffective. We present AIR-BEN…
  datacite Naphade, Rohan, Pan, Minzhou, Li, Bo 2026 置信度 0.66 Artificial Intelligence (cs.AI)FOS: Computer and information sciences
• Recursive Ai with Codette
  **Terminology correction (July 2026).**> This work uses the label "RC+ξ" for its recursive-state formalism. That term> and its associated formalism were introduced independently and earlier by> **Jeffrey Camlin, *Recursive Consciousness + ξ*, arXiv:2505.01464 …
  datacite Harrison, Jonathan 2026 置信度 0.66
• Recursive Ai with Codette
  **Terminology correction (July 2026).**> This work uses the label "RC+ξ" for its recursive-state formalism. That term> and its associated formalism were introduced independently and earlier by> **Jeffrey Camlin, *Recursive Consciousness + ξ*, arXiv:2505.01464 …
  datacite Harrison, Jonathan 2026 置信度 0.66
• Chasing Crows
  Chasing Crows ByVoight KampffThis road had been longer than the memory could recall, he hated it.It had morphed from motorway to road, to track and now to narrow path. It dissolved into nothing but a lonesome tree, this was no oasis nor the foot of a castle bu…
  datacite Weatherill, Mark 2026 置信度 0.66
• New Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma.
  In 2024, an estimated 100,640 new cases of invasive melanoma were diagnosed in the U.S., with 9290 deaths. Our previous studies revealed that neuronal nitric oxide synthase (nNOS) derived nitric oxide plays a critical role in melanoma progression, making nNOS …
  pubmed Awasthi A, Patel A, Li H, Kang KM 等 2026 Feb 12 置信度 0.82
• Targeting MCL-1 and MAPK overcomes venetoclax resistance in FLT3-ITD-positive AML cells harbouring activating PTPN11 (SHP-2) mutations.
  Venetoclax (VEN)-based therapies have improved the treatment of acute myeloid leukaemia (AML); however, the emergence of resistance remains a major limitation. Mutations in protein tyrosine phosphatase (PTP) non-receptor type 11 (PTPN11) and FMS like tyrosine …
  pubmed Fleischmann M, Hansen O, Voigtländer D, Bechwar J 等 2026 Mar 置信度 0.82
• In Silico Identification of Antiviral Peptides as Potential Leads Against Sudan Ebolavirus VP-40.
  The continued reemergence of Ebola virus epidemics remains a global health concern, largely due to limited therapeutic interventions. This study is aimed at identifying and characterizing antiviral peptides as potential lead candidates against the Sudan Ebola …
  pubmed Omara B, Kiyimba K, Fofana FG, Diabaté O 等 2026 置信度 0.82
• Comparative risk of systemic autoimmune diseases in juvenile idiopathic arthritis treated with TNF-α or IL-6 inhibitors: a real-world cohort study.
  This study aimed to compare the risk of developing systemic autoimmune diseases (SADs) among pediatric patients with juvenile idiopathic arthritis (JIA) treated with tumor necrosis factor inhibitors (TNFi) versus interleukin-6 inhibitors (IL-6i), based on real…
  pubmed Tsai JJ, Liu LT, Lin PC, Wang YH 等 2025 置信度 0.82
• Juvenile Behçet's disease 2014-2024: multicenter study in Colombia.
  Juvenile Behçet's disease (JBD) is a rare multisystem inflammatory disorder that primarily affects the oral and genital mucosa, as well as vessels of any caliber. Between 4% and 26% of Behçet's disease cases begin before the age of 16. JBD remains un…
  pubmed Zabala-Sepúlveda LM, Yepes-Madrid N, Gómez-Mora MD, Yépez-Zambrano RE 等 2026 Jan 28 置信度 0.82
• Dalpicilib combined with cetuximab in patients with HPV-negative, anti-PD-1-resistant recurrent or metastatic head and neck squamous cell carcinoma: A phase II trial.
  Human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) is characterised by hyperactivation of the cyclin-dependent kinase 4/6 (CDK4/6) pathway. As immunotherapy has become the first-line treatment for HNSCC, resistance to anti-progra…
  pubmed Ju H, Wu Y, Shi C, Xia R 等 2026 Jan 28 置信度 0.82
• The Development and Use of AI Chatbots for Health Behavior Change: Scoping Review.
  Artificial intelligence (AI) chatbots are technologies that facilitate human-computer interaction through communication in a natural language format. By increasing cost-effectiveness, interaction, autonomy, personalization, and support, mobile health intervent…
  pubmed Fu L, Burns R, Xie Y, Shen J 等 2026 Jan 28 置信度 0.82
• Comparison of the Efficacy of Denosumab and Alendronate in Improving Bone Mineral Density in Osteoporosis Patients and High-Risk Populations: A Systematic Review and Meta-Analysis.
  Osteoporosis, a common condition of low bone mineral density (BMD), significantly increases fracture risk. Denosumab and alendronate are both established anti-resorptive therapies, yet their comparative effectiveness remains inconsistent across studies.
  pubmed Zhu K, Li H, Zhang H, Zhou Z 等 2026 Mar 置信度 0.82
• The Role of mTOR Inhibitors in COVID-19 Outcomes Among Heart Transplant Recipients.
  Heart failure (HF) remains a major global health challenge, with orthotopic heart transplantation (OHT) serving as the gold-standard therapy for end-stage disease. Chronic immunosuppression required to prevent graft rejection increases the risk of infections a…
  pubmed Kuczaj A, Warwas S, Tyrka M, Skotnicki B 等 2025 Dec 24 置信度 0.82
• Genomic Characterization of Clinical Canine Parvovirus Type 2c Infection in Wild Coyotes (Canis latrans) in Mexico.
  Canine parvovirus type 2 (CPV-2) is a primary etiological agent of acute gastroenteritis in domestic dogs. Although molecular and serological evidence have confirmed its circulation in wild carnivores, the clinical impact of spillover events in wildlife hosts …
  pubmed Busqueta-Medina A, Ávalos-Ramírez R, Zamora-Ávila DE, Aguirre-Arzola VE 等 2026 Jan 11 置信度 0.82
• Dissecting the Interaction Domains of SARS-CoV-2 Nucleocapsid Protein and Human RNA Helicase DDX3X and Search for Potential Inhibitors.
  The SARS-CoV-2 nucleocapsid protein (Np) plays multifunctional roles in the viral life cycle. By interacting with host cellular proteins, Np regulates viral RNA transcription, replication, and immune evasion. It controls genome packaging and counteracts host R…
  pubmed Lodola C, Pallotta MM, Manetti F, Governa P 等 2026 Jan 9 置信度 0.82
• In Vitro Study on the Effects of Rhododendron mucronulatum Branch Extract, Taxifolin-3-O-Arabinopyranoside and Taxifolin on Muscle Loss and Muscle Atrophy in C2C12 Murine Skeletal Muscle Cells.
  Sarcopenia, an age-related muscle atrophy disease, is a major health concern in aging societies and is closely associated with severe chronic diseases. Its primary pathogenesis involves oxidative stress-induced apoptosis in muscle cells and an imbalance in pro…
  pubmed Lee HS, Jang HD, Kim TH, An DH 等 2026 Jan 6 置信度 0.82
• Impact of Computational Histology AI Biomarkers on Clinical Management Decisions in Non-Muscle Invasive Bladder Cancer: A Multi-Center Real-World Study.
  Background/Objectives : Non-muscle invasive bladder cancer (NMIBC) management is increasingly complex due to conflicting guideline-based risk classifications, ongoing Bacillus Calmette-Guérin (BCG) shortages, and emerging alternative therapies. Computatio…
  pubmed Packiam VT, Ghodoussipour S, Konety BR, Ahmadi H 等 2026 Jan 14 置信度 0.82
• Structural and Computational Insights into the Angiotensin II Type 1 Receptor: Advances in Antagonist Design and Implications for Hypertension Therapy (2020-2024).
  The renin-angiotensin-aldosterone system (RAAS) is essential for controlling blood pressure and maintaining fluid balance, driving significant structural changes throughout the cardiovascular system, including the heart and blood vessels. As a result, the RAAS…
  pubmed Chatzipieris FP, Petsas E, Lambrinidis G, Matsoukas JM 等 2025 Dec 22 置信度 0.82
• Seed Treatment with Fluopyram Provides Effective Management of Soybean Cyst Nematode (Heterodera glycines) and Enhances Soybean Growth.
  Soybean cyst nematode (SCN, Heterodera glycines ) is one of the most yield-limiting nematodes in soybean production. Application of synthetic nematicides is a critical component in the integrated management of SCN in China. However, resistance has developed in…
  pubmed Ji X, Zhao Y, Han S, Sun G 等 2026 Aug 置信度 0.82
• Combining waterlase ablation and submucosal ALA injection to enhance photodynamic therapy in early-stage oral squamous cell carcinoma: a three-patient case series.
  Oral squamous cell carcinoma (OSCC), a common type of oral cancer, has traditionally relied on surgery or radiotherapy as the main treatment. However, these treatments often put patients at risk of deformity and speech dysfunction due to the special anatomical…
  pubmed Zheng F, Dong L, Han L, Wang Y 等 2026 Jan 26 置信度 0.82
• Cadonilimab rechallenge in patients with recurrent or metastatic cervical cancer following prior PD-1/PD-L1 inhibitor failure: a retrospective multicenter study.
  Patients with recurrent or metastatic cervical cancer (R/M CC) who progress after immunotherapy face limited treatment options. This study aimed to explore whether cadonilimab, a novel bispecific antibody targeting programmed cell death protein 1 (PD-1)/cytoto…
  pubmed Yu H, Chen J, Lin J, Chen L 等 2025 置信度 0.82
• Clinical patterns, species-specific correlations, and therapeutic outcomes of nocardiosis in immunocompetent individuals: a systematic analysis based on literature.
  Nocardiosis, traditionally an opportunistic infection, lacks comprehensive characterization in immunocompetent individuals. This study aimed to describe and analyze the demographics, clinical features, and outcomes of Nocardia infections in this population bas…
  pubmed Lu L, Wang D, Li M, Yang X 等 2026 Jan 25 置信度 0.82
• Safety and efficacy of CRS3123 in adults with a primary episode or first recurrence of Clostridioides difficile infection: a phase 2, randomised, double-blind, multicentre, vancomycin-controlled study.
  CRS3123 is a potent inhibitor of protein synthesis in bacteria that express type 1 methionyl-tRNA ligase, resulting in selective antibacterial activity that holds promise as a novel treatment for Clostridioides difficile infection (CDI). The purpose of this st…
  pubmed Louie T, Ribble W, Boccumini L, Johnson K 等 2026 May 置信度 0.82
• Ending Tuberculosis through prevention: Zimbabwe's PEPFAR Tuberculosis preventive treatment scale-up journey (2016-2024).
  BackgroundTuberculosis (TB) is the leading cause of death among people living with HIV (PLHIV). Globally in 2023, an estimated 161,000 PLHIV died of TB. TB preventive treatment (TPT) can reduce TB mortality yet scale up remains a challenge. We documented Zimba…
  pubmed Maphosa T, Cham HJ, Marisa C, Bulaya-Tembo R 等 2026 May 置信度 0.82
• Recent advances in bispecific antibody-drug conjugates for breast cancer therapy.
  Bispecific antibody-drug conjugates (BsADCs) represent a promising strategy to overcome limitations of conventional ADCs in breast cancer, such as tumor heterogeneity and inefficient internalization. This review summarizes recent advances and the therapeutic p…
  pubmed Ji X, Yang Y, Ma C, Huang W 等 2026 Jan 24 置信度 0.82
• Current status and emerging trends in biological therapies for ankylosing spondylitis: A bibliometric analysis (2004-2024).
  Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by pain and stiffness in the spine and sacroiliac joints. It significantly reduces quality of life and imposes substantial social and economic burdens. Advances in understanding AS hav…
  pubmed Deng R, Jiang X, Zhong XX, Shen F 等 2026 Jan 23 置信度 0.82
• Sexual dysfunction in Brazilian women undergoing adjuvant endocrine therapy for breast cancer: prevalence and associated factors.
  This study aimed to describe the frequency of sexual dysfunction among women undergoing adjuvant endocrine therapy (ET) and explore its relationship with patients' clinical, social, and demographic characteristics. We evaluated women with a history of non-meta…
  pubmed Assad-Suzuki D, Laperche-Santos D, Resende H, Moura FC 等 2026 Jan 24 置信度 0.82
• Integrated Morphoanatomical, Phytochemical, and Bioactive Insights Into the Ethnomedicinal Plant Daphniphyllum neilgherrense.
  Daphniphyllum neilgherrense (Daphniphyllaceae), an ethnomedicinal plant, is used for skin diseases and various ailments, for which the studies on its anatomical, phytochemical and pharmacological properties are unexplored. Hence, the present study has been aim…
  pubmed Soundarya V, Mohanasundaram S, Venkatesa Prabhu S, Radha P 等 2026 Jan 置信度 0.82
• Evaluating the Impact of a Surgeon-Led Ductal Carcinoma in Situ Program on Endocrine Therapy Uptake.
  Despite the known clinical benefit of endocrine therapy (ET) after surgery for ductal carcinoma in situ (DCIS), ET uptake remains low. In April 2021, the authors initiated a surgeon-led DCIS program. This report evaluates the impact of the DCIS program on ET u…
  pubmed Masanam MK, Kantor O, Pappas Brunco O, Faust AC 等 2026 May 置信度 0.82
• Emerging trends and hotspots in Oseltamivir resistance: insights from a bibliometric investigation.
  Influenza has long been a serious global public health problem, and the risk of drug resistance to Oseltamivir, as a first-line antiviral drug, cannot be ignored. Although some research findings have been published, a systematic review of current research on O…
  pubmed Zhai S, Dou Y, Cui Z, Yuan B 2026 Apr 置信度 0.82
• Exploration of the mechanism of anlotinib in reversing PD-1 immunotherapy resistance: insights from single-cell sequencing.
  Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis have revolutionized cancer therapy, yet primary and acquired resistance remain major clinical obstacles. Dysregulated angiogenesis fuels the development of an immunosuppressive tumor microenviro…
  pubmed Shi W, Zhang Y, Yu Q, Li H 等 2026 Feb 置信度 0.82
• Basroparib inhibits YAP-driven cancers by stabilizing angiomotin.
  Yes-associated protein (YAP) is a key oncogenic effector and a well-established driver of resistance to anticancer therapies, especially in tumors harboring KRAS mutations. Although YAP is clinically relevant, drug-development efforts that directly inhibit its…
  pubmed Kwon YJ, Kim DY, Kim Y, Kim UI 等 2026 May 置信度 0.82
• A cluster randomized trial of Visitect CD4 Advanced Disease platform among outpatients with advanced HIV disease in Uganda.
  Despite significant progress in HIV care globally, a persistent 30-40% of people present with advanced HIV disease with ≤200 CD4 cells/µl. The Visitect CD4 Advanced Disease platform is a point-of-care CD4 test being implemented in resource-limited …
  pubmed Nalintya E, L Schwartz E, Nerima P, Fieberg A 等 2026 Jan 置信度 0.82
• Effects of Lenvatinib treatment for advanced differentiated thyroid cancer on cortisol deficiency.
  Lenvatinib, a multi-kinase inhibitor widely used in the treatment of radioiodine-refractory differentiated thyroid carcinoma (RR-DTC), has shown remarkable efficacy and improvement in progression-free survival (PFS), although its use is associated with a varie…
  pubmed Monti S, Fazzalari B, Renzelli V, Bongermino C 等 2025 置信度 0.82
• Emerging Frontiers in Clinical Mycology: Innovations, Insights, and Impacts.
  The Mycoses Study Group Education and Research Consortium (MSGERC)-a group comprising clinicians, researchers, patients, and industry partners-meets every 2 years to review the most significant challenges facing the clinical mycology community and plan …
  pubmed Apostolopoulou A, Stewart AG, Yoon H, Steinbrink JM 等 2026 Jan 置信度 0.82
• Vascular Hyporesponsiveness in Sepsis Is Associated With Nitric Oxide-Dependent Activation of G-Protein Receptor Kinase.
  Sepsis is a life-threatening condition caused by a dysregulated host response to infection that often leads to profound end organ derangement in which vascular system dysfunction plays a critical role. Septic shock is characterized by a pronounced decrease in …
  pubmed Dal-Secco D, Olivon VC, Celes MRN, Crestani S 等 2026 Mar 1 置信度 0.82
• Efficacy and safety of anti-inflammatory drug-assisted treatment of symptoms in patients with schizophrenia: a meta-analysis.
  BACKGROUND: Although anti-inflammatory agents have been explored as adjunctive treatments for schizophrenia, findings remain inconsistent. While some meta-analyses suggest benefit, concerns persist regarding methodological heterogeneity, language bias, and the…
  pubmed Li H, Shen H, Duan X, Guo M 等 2026 Jan 20 置信度 0.82
• PET imaging of alpha-synuclein: from radiotracer design through in vitro and in vivo translation.
  The development of positron emission tomography (PET) tracers targeting α-synuclein (α-syn) aggregates remains a major challenge in PET imaging of neurodegenerative diseases. This review provides a comprehensive overview of the recent advances, key…
  pubmed Pees A, Grotegerd AK, Bleher D, Herfert K 等 2026 May 置信度 0.82
• Temporal evolution of digital health communication in Rheumatoid Arthritis: A longitudinal NLP analysis of reddit discussions (2018-2024).
  Rheumatoid arthritis (RA) is a chronic autoimmune condition characterized by joint pain, fatigue, and reduced quality of life. Although pharmacological interventions, such as non-steroidal anti-inflammatory drugs (NSAIDs) and disease-modifying antirheumatic dr…
  pubmed Patel N, Sharma R, Lingasamy P, Sundararajan V 等 2026 置信度 0.82
• eBIMIC: development of a web platform for real-time access to cumulative antimicrobial susceptibility reports and its potential impact on evidence-based antibiotic prescribing in bacteremia.
  Timely knowledge of local epidemiology is essential for guiding appropriate antibiotic therapy in severe infections such as bloodstream infections (BSI). In 2024, we developed "eBIMIC", a web-based application that enables real-time parameterized consultation …
  pubmed Hernández S, Colomina J, Giménez E, Medina A 等 2026 Apr 置信度 0.82
• Isolation and purification of polysaccharides from Centella Asiatica followed by structural characterization and evaluation of antidiabetic activity.
  Natural polysaccharides derived from plants have demonstrated significant antidiabetic properties by effectively alleviating hyperglycemia, improving insulin resistance, and preventing diabetes-associated complications. In this study, polysaccharides were extr…
  pubmed Li M, Xiong T, Bi J, Law D 等 2026 Jan 19 置信度 0.82
• Strategic risk assessment in oncology: Utilizing single-agent activity to boost combination therapy approvals.
  This study examines whether single-agent activity in early clinical phases correlates with the approval likelihood of combination therapies in oncology. Using the Intelligencia AI database, we investigated the impact of monotherapy efficacy on the success rate…
  pubmed Kasim A, Anastasiou M, Loizou E, Dimakakos A 等 2026 Feb 置信度 0.82
• Implications of empirical testing and treatment for atypical bacteria in patients hospitalized with COVID, influenza, or RSV: a retrospective observational cohort study.
  PURPOSE: Patients admitted with viral respiratory tract infections are at risk ofbacterial co-infections that may exacerbate disease severity. Detection of atypical bacteria requires specific laboratory diagnostic modality and specific antibiotics. METHODS: In…
  pubmed Hønge BL, Redder J, Greve T, Dalgaard LS 等 2026 Apr 置信度 0.82
• Clinical effectiveness of long-acting injectable antipsychotics in schizophrenia spectrum disorders: real-world mirror-image evidence.
  Long-acting injectable (LAI) antipsychotics are increasingly utilized to address non-adherence and improve clinical stability in patients with chronic psychiatric disorders. However, real-world data comparing different LAI formulations remain limited. This ret…
  pubmed Kurt Tunagur EM, Tunagur MT 2026 Jan 16 置信度 0.82
• Aflibercept 8 mg treat-and-extend pathway for the treatment of neovascular age-related macular degeneration: guidance from a UK expert panel.
  Therapies with robust visual outcomes and reduced patient and healthcare system treatment burden are needed amidst the rising incidence of neovascular age-related macular degeneration (nAMD). Aflibercept 8 mg is an additional treatment option with demon…
  pubmed Gale R, Awad MH, Bailey C, Cackett P 等 2026 May 置信度 0.82
• Narciclasine Alleviates Endothelial Inflammation and Atherosclerosis Initiation by Inhibiting Histone Lactylation-Mediated NF-κB Activation.
  Glycolysis-derived lactate serves as a substrate for lysine lactylation, an epigenetic modification playing critical transcriptional regulatory roles in inflammatory diseases. Endothelial inflammation, characterized by upregulated glycolysis, initiates atheros…
  pubmed Wang Z, Zhang Z, Xin R, Ma M 等 2026 Jan 16 置信度 0.82
• A Mechanism-Based Multi-Level Population PK/PD Model for Potassium-Competitive Acid Blockers.
  Potassium-competitive acid blockers (PCABs) are emerging alternatives to proton pump inhibitors for the treatment of acid-related diseases. However, due to the complex, nonlinear interaction between drug exposure, food intake, and physiological rhythms, optimi…
  pubmed Jung W, Lee J, Jeon H, Sung T 等 2026 Jan 置信度 0.82
• Trends in nephrology: from "supportive care" to CKD combination therapy.
  Chronic kidney disease (CKD) management has evolved from supportive care with renin-angiotensin system inhibitors (RASi) alone to multi-target combination therapies. While RASi remain foundational, their limited efficacy in fully preventing disease progression…
  pubmed He K, Guo Y, Yang C, Johnson DW 等 2026 Jun 30 置信度 0.82
• A nationwide study of invasive Streptococcus agalactiae in the Faroe Islands from 2009 to 2024.
  Group B Streptococcus (GBS, Streptococcus agalactiae) is a leading cause of invasive disease in neonates, pregnant women, elderly, and immunocompromised individuals. The epidemiology of invasive GBS disease remains poorly documented in small, isolated populati…
  pubmed Joensen Ó, Krogfelt KA, Gaini S, Slotved HC 2026 Jan 13 置信度 0.82
• Intelectin-2 is a broad-spectrum antimicrobial lectin.
  Mammals regulate the localization, composition, and activity of their native microbiota at colonization sites. Lectins residing at these sites influence microbial populations, but their functional roles are often unclear. Intelectins are found in chordates at …
  pubmed Dugan AE, Syangtan D, Nonnecke EB, Chorghade RS 等 2026 Jan 13 置信度 0.82
• Integrated Phenotypic-Genotypic Surveillance of Neuraminidase Inhibitor Susceptibility in Influenza A(H1N1), A(H3N2), and B/Victoria Viruses in Saudi Arabia, 2024-2025.
  Contemporary neuraminidase inhibitor (NAI) surveillance data from the Middle East are limited. We profiled current-season susceptibility among influenza A(H1N1), A(H3N2), and B/Victoria viruses circulating in Saudi Arabia (2024-2025) using paired phenotypic an…
  pubmed Naeem A, Hakami M, Aljami H, Almiqbel HS 等 2026 Jan 置信度 0.82
• Adherence, Preference, and Acceptability of an Overencapsulated Dual Prevention Pill for HIV and Pregnancy Prevention Among Women in Johannesburg, South Africa.
  Oral preexposure prophylaxis (PrEP) is safe and effective for HIV prevention, but use among women has been suboptimal. A dual prevention pill (DPP) coformulating PrEP and a combined oral contraceptive (COC) may increase PrEP use.
  pubmed Ndlovu N, Plagianos M, Palanee-Phillips T, Reddy K 等 2026 Feb 1 置信度 0.82
• Exploration of Pregnant and Breastfeeding Women's Acceptability of Rapid Point-of-Care Urine Testing Within Antenatal and Postnatal Care, and Its Perceived Impact on PrEP Adherence When Paired with PrEP Biofeedback Adherence Counselling in Cape Town, South Africa.
  Pregnant and breastfeeding women (PBFW) on oral pre-exposure prophylaxis (PrEP) face barriers to adherence and persistence which may be improved by point-of-care adherence monitoring using urine tenofovir testing. We explored the acceptability of urine tenofov…
  pubmed Court L, Mvududu R, Schoetz Dean S, Knight L 等 2026 Jun 置信度 0.82
• VEGF-inhibitor switch trial in poor-responsive neovascular age-related macular degeneration: assessing brolucizumab vs. faricimab: VISTA study.
  To compare short-term (12 weeks) and long-term (48 weeks) anatomical and functional outcomes after switching to brolucizumab (BRZ) or faricimab (FAR) under a treat-and-extend (TAE) regimen without an initial loading phase in eyes with poor-responsive neovascul…
  pubmed Kilani A, Vogt D, Moysidi V, Assaf A 等 2026 May 置信度 0.82
• Effect of probiotic strain, duration, and dose on preventing ICU-acquired infection: A scoping review.
  Intensive care unit-acquired infections (ICU-AIs) are prevalent among critically ill patients due to multiple invasive procedures. Probiotics have emerged as a potential preventive strategy to lower infection rates in ICU settings. However, studies assessing p…
  pubmed Al-Aklabi AM, Alotaishan SM, Al-Gindan YY, Khattab RY 2026 Mar 置信度 0.82
• Long-term trends in androgen-directed therapy in advanced prostate cancer: a 29-year national analysis.
  Androgen deprivation therapy (ADT) has been pivotal in advanced prostate cancer (PCa) for decades. The introduction of androgen-receptor pathway inhibitors (ARPIs) has transformed treatment paradigms. However, their real-world adoption over time has not been c…
  pubmed Sandhu K, Wells C, Newton MMH, Murphy DG 等 2026 Jul 置信度 0.82
• Recent advances in biologic therapies for ankylosing spondylitis: A 2024 update.
  Ankylosing spondylitis (AS), a long-term autoimmune disorder characterized by systemic inflammation, manifests as gradually worsening arthritis predominantly affecting the spinal column and sacroiliac joints. While emerging biologic agents have broadened treat…
  pubmed Yu G, Yuan N, Liu D, Nie D 等 2026 置信度 0.82
• Orolabial and Genital Herpes Clinical Trials: A Meta-analysis of Endpoints.
  Although several antiviral agents are licensed for the treatment of orolabial and genital herpes simplex virus infections, new therapies are needed. Trial design is challenging for these indications due to the heterogeneity of endpoints in prior trials. We con…
  pubmed Sloan A, Mortezavi M, Gerhart J, Banerjee A 等 2026 Jan 置信度 0.82
• The investigational anti-B7-H3 antibody-drug conjugate vobramitamab duocarmazine exerts anti-tumor activity in vitro and in vivo in pediatric sarcoma preclinical models.
  Prognosis for pediatric sarcoma (pSC)-affected patients, especially those with relapsed/refractory disease, is dismal. The available treatment options are unsatisfactory, challenging researchers to address this unmet need. The investigational B7-H3 targeted AD…
  pubmed Bianchi G, Pastorino F, Rolandi G, Ciampi E 等 2026 Jan 8 置信度 0.82
• Integrating HIV and Stimulant-Use Disorder Treatment: A Pilot Implementation Effectiveness Trial of Contingency Management in HIV Care.
  Stimulants, including cocaine and methamphetamine, are associated with HIV transmission and viremia. Contingency management (CM), which provides financial incentives for nonreactive urine testing, is first-line treatment for stimulant-use disorder (StUD), yet …
  pubmed Appa A, Steiner G, Baral S, Riley E 等 2026 Apr 30 置信度 0.82
• Microbial exopolysaccharide pullulan-based seed priming combined with Chlorella vulgaris enhances salinity tolerance in maize.
  Salinity is a major abiotic stress limiting global maize (Zea mays L.) production. This study evaluated the biostimulant potential of pullulan, an exopolysaccharide produced by Aureobasidium pullulans ATCC 42,023, applied alone or in combination with the micro…
  pubmed Vilca Pascuali C, Delgado Pineda D, Colina Andrade G, Terán Hilares R 2026 Jan 8 置信度 0.82
• Leveraging generative AI to enhance Synthea model development.
  To explore the use of large language models (LLMs) to assist in developing new agent-based disease-specific patient journey models.
  pubmed Kramer MA, Mathur A, Adams CE, Walonoski JA 2026 Feb 置信度 0.82
• Impact of vascular endothelial growth factor inhibitor-induced hypertension on continued cancer treatment: a systematic review and meta-analysis.
  The administration of bevacizumab, ramucirumab, and aflibercept increases the incidence of hypertension; however, the risk of discontinuation of cancer therapy due to hypertension from these medications remains unclear. A systematic review and meta-analysis we…
  pubmed Nishizaki M, Shibutani Y 2026 Apr 置信度 0.82
• PCSK9 and ANGPTL3 Inhibitors in Homozygous Familial Hypercholesterolemia: A Meta-analysis of Randomized Clinical Trials.
  The aim of this meta-analysis was to compare the efficacy of PCSK9 and ANGPTL3 inhibitors in patients with homozygous familial hypercholesterolemia (HoFH).
  pubmed Bytyçi I, Henein MY, Bytyqi S, Shatri M 等 2026 Feb 置信度 0.82
• Anti-ANGPTL3 Antibody SHR-1918 for Homozygous Familial Hypercholesterolemia: A Nonrandomized Clinical Trial.
  Homozygous familial hypercholesterolemia (HoFH) is a rare, life-threatening genetic disorder. Patients with HoFH have markedly elevated low-density lipoprotein cholesterol (LDL-C) levels from birth, and their activity of LDL receptor (LDLR) is typically absent…
  pubmed Peng D, Wang L, Pi L, Xu Y 等 2026 Feb 1 置信度 0.82
• Designing novel FAK inhibitors targeting gastric cancer: a combined approach using machine learning, docking analysis, molecular dynamics simulations, and experimental validation.
  Gastric cancer, the fifth most common cancer worldwide, causes over 650,000 deaths each year. Although targeted therapies have shown effectiveness in advanced stages, their success is often limited by side effects and resistance mechanisms. Focal adhesion kina…
  pubmed He X, Wan Q, Zhou Y, Yan J 等 2026 Jan 7 置信度 0.82
• Exploring the Probiotic and Antimicrobial Potential of Pediococcus Pentosaceus Isolates from Fish: Genomic and Functional Perspectives.
  Aquaculture faces increasing challenges related to disease management and the need for sustainable alternatives to antibiotics that ensure productivity, fish welfare, and environmental sustainability. Probiotic bacteria, particularly lactic acid bacteria (LAB)…
  pubmed Frota EG, Kuniyoshi TM, Oliveira MM, Azevedo POS 等 2026 Jun 置信度 0.82
• Somatic gene mutations and their association with treatment outcomes among Indo-Asian Lung Cancer patients.
  Insight on genetic mutation has essentially helped clinicians in determining treatment outcomes in lung cancer (LC) due to precision and personalized approach. This study evaluates the mutation trends, treatment responses, prognosis and overall survival (OS) 6…
  pubmed Kulsum S, Pradhan A, Coca P, Zaidi SN 等 2026 置信度 0.82
• Protective Effect of luteolin on CLP-induced Sepsis-associated Encephalopathy via Inhibiting p38 MAPK Signalling in a Rat Model.
  The present study explored the neuroprotective potential of luteolin using a Cecal ligation and puncture (CLP)-subjected rat model of SAE. CLP significantly impaired cognitive and motor functions through impaired performance in the open field test, novel objec…
  pubmed Kumar R, Singh H, Hanifa M, Suri M 等 2026 Jan 6 置信度 0.82
• Screening and Diagnosis of Primary Aldosteronism in Patients Using Renin-Angiotensin System Inhibitors.
  This study investigated whether patients receiving renin-angiotensin system inhibitors (RASIs) can undergo reliable screening for primary aldosteronism (PA) without discontinuation of therapy. Consecutive patients with hypertension who underwent PA screening a…
  pubmed Wang Q, Dong H, Li HW, Zou YB 等 2026 Jan 置信度 0.82
• Early reperfusion with tenecteplase vs alteplase before stroke thrombectomy: impact of clot burden, thrombus characteristics, and collateral status.
  Early reperfusion (ER) following intravenous thrombolysis improves outcomes in large vessel occlusion stroke (LVOS). Tenecteplase (TNK) has been associated with higher ER rates than alteplase (TPA), but findings across studies remain inconsistent, possibly due…
  pubmed Bielinski TM, Kline KE, Badger GN, Bohl VN 等 2026 Jan 5 置信度 0.82
• Margatoxin Peptide: Preparation and the Potential Use for Biological Applications in Cancer and Neurological Disorders.
  Scorpion venom compounds are known to contain nucleotides, polypeptides, mucoproteins, lipids, biogenic amines, and other unidentified macromolecules. Several peptides in scorpion fluids have demonstrated a wide range of biological activities with strong speci…
  pubmed Ranjbari F, Dadkhah M, Pirdel Z, Fathi F 2025 置信度 0.82
• Pharmacological transglutaminase 2 inhibition enhances temozolomide response in patient-derived glioblastoma tumorspheres.
  PURPOSE: Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor, with a median survival of less than two years despite standard therapy. Transglutaminase 2 (TGM2) contributes to tumor progression and poor clinical outcomes. This stu…
  pubmed Hong JP, Hong JB, Lee B, Choi RJ 等 2026 Jan 3 置信度 0.82
• Retrospective analysis of the impact of antidepressants with anti-acid sphingomyelinase activity on survival of patients with glioblastoma.
  PURPOSE: Glioblastoma (GBM) is the most common malignant primary brain tumor in adults and remains difficult to treat. Though still under investigation, acid sphingomyelinase (ASM) has been implicated in GBM lipid raft formation, which facilitates cancer signa…
  pubmed Liu CM, Medeiros Geraldo LH, Xiao J, Sulman EP 2026 Jan 3 置信度 0.82
• Transcription of HIV-1 is heterogenous among authentic latent CD4+ T cell clones.
  Antiretroviral therapy suppresses HIV-1 infection but fails to eliminate a reservoir of intact latent proviruses that reside primarily in CD4+ T cells. The lack of precise understanding of the latent compartment has made it challenging to develop curative stra…
  pubmed Bittar C, Teixeira AR, Oliveira TY, Silva Santos GS 等 2026 Mar 2 置信度 0.82
• Impact of an analytical treatment interruption on partners and family members of trial participants in Durban, South Africa: a qualitative study.
  HIV cure-related research often include analytical treatment interruptions (ATIs), which are monitored pauses in antiretroviral therapy (ART) to determine whether interventions can stimulate viral control without ART. While ATIs have been conducted in high-inc…
  pubmed Dong KL, Ngcobo MW, Langa N, Zulu A 等 2025 置信度 0.82
• An Assessment of Regional Genetic Diversity of HIV-1.
  This study aimed to assess the genetic diversity of HIV-1 in the Far Eastern Federal District (Russia) to implement effective anti-epidemic measures, including the development of an anti-HIV vaccine and the selection of optimal antigens. The first stage of the…
  pubmed Antonova A, Kuznetsova AV, Kuznetsova AI, Mazus A 等 2025 Nov 30 置信度 0.82