AI Agent 生态 · 全部实体（第 53 / 100 页）

本页收录第 5201–5300 条，共 10000 条 · 返回 AI Agent 生态 首页

• Gene expression analysis of diabetic foot ulcers reveals the potential impact of Levofloxacin on wound healing.
  Chronic nonhealing wounds in diabetic patients represent a significant and persistent clinical challenge, contributing to the increased morbidity and mortality of patients with diabetes worldwide. The selection of an appropriate treatment strategy is crucial f…
  pubmed Hassan N, Ilyas A, Memon MF, Shafiq Y 等 2025 Dec 30 置信度 0.82
• Direct Transport to a Thrombectomy Center Accelerates Acute Stroke Reperfusion Therapies in Nonurban Settings.
  In the United States, the impact of bypassing the nearest local stroke center to facilitate direct transport of nonurban patients to a thrombectomy-capable center (TCC) for mechanical thrombectomy (MT) remains unclear. We compared intravenous thrombolysis and …
  pubmed Bhatt NR, Al-Qudah AM, Martin-Gill C, Guyette FX 等 2026 Jan 6 置信度 0.82
• Pharmacokinetic interactions and clinical implications of PPIs and CDKIs in breast cancer: a systematic review and meta-analysis.
  Breast cancer is the fourth leading cause of cancer mortality worldwide. New drugs, such as cyclin-dependent kinase 4/6 inhibitors (CDKIs), increase the life expectancy of receptor-positive (HR+) and human epidermal growth factor receptor 2 negative (HER2-) br…
  pubmed Graziosi A, Pane R, Tinazzo E, Basso M 等 2025 Dec 30 置信度 0.82
• Broad-spectrum antiviral activity of ebselen.
  Broad-spectrum antivirals are essential for pandemic preparedness, helping reduce mortality and mitigate social disruption. Ebselen, a synthetic organoselenium compound, is under investigation for treating various conditions, including viral infections. We dem…
  pubmed Jitobaom K, Boonyuen U, Boonarkart C, Sirihongthong T 等 2025 Dec 29 置信度 0.82
• Angiotensin receptor-neprilysin inhibitors improve the outcome of lung cancer patients with hypertension undergoing immune checkpoint inhibitors treatment.
  Angiotensin receptor-neprilysin inhibitors (ARNIs) could improve the outcome of patients with hypertension or heart failure. Yet it remains unclear if such protective effect exists in lung cancer patients with hypertension undergoing immune checkpoint inhibito…
  pubmed Shang C, Wang H, Chen J, Cao S 等 2025 Dec 27 置信度 0.82
• Graph attention-based heterogeneous multi-agent deep reinforcement learning for adaptive portfolio optimization.
  Traditional portfolio optimization methods face significant limitations in capturing complex asset relationships and adapting to dynamic market conditions. This paper proposes a novel graph attention-based heterogeneous multi-agent deep reinforcement learning …
  pubmed Zhang B 2025 置信度 0.82
• Exploring acenocoumarol and silodosin in non-small cell lung cancer: Insights into EGFR-linked signaling mechanisms.
  Non-small-cell lung cancer (NSCLC) is a highly morbid disease. Chemotherapy for NSCLC lacks specificity and efficacy mainly because of drug resistance. The current study aimed to explore computational tools to target allosteric epidermal growth factor receptor…
  pubmed Maity S, Baby K, Byregowda BH, Vithalkar MP 等 2024 置信度 0.82
• Lebrikizumab-lbkz for the Treatment of Atopic Dermatitis: A Drug Review.
  Lebrikizumab is a monoclonal antibody targeting interleukin 13 (IL-13), a key cytokine in the pathogenesis of atopic dermatitis (AD). It was approved by the Food and Drug Administration (FDA) in 2024 for the treatment of moderate-to-severe AD in patients aged …
  pubmed Nasim D, Shaffer B, Feldman SR 2026 Jul 置信度 0.82
• Enhanced overall and progression-free survival in advanced melanoma patients undergoing targeted therapy alongside antithrombotic treatment - Insights from a multicenter study involving 1296 patients from the prospective skin cancer registry ADOReg.
  Targeted therapies (TT) improve outcomes in BRAF-mutant melanoma. Pre-clinical data suggest that anticoagulation (AC) and platelet aggregation inhibition (PAI) may have antitumoral effects. We evaluated the impact of concomitant AC or PAI on outcomes in patien…
  pubmed Zimmermann N, Kött J, Zell T, Abedini AZ 等 2026 Feb 5 置信度 0.82
• Development of cell-active BRD4-D1 selective inhibitors to decode the role of BET proteins in LPS-mediated liver inflammation.
  The endogenously expressed BET proteins (BRD2, BRD3, BRD4) are upstream clinical targets for anti-inflammatory treatments, where inhibition of the tandem bromodomains (D1 and D2) have proven efficacious in vitro and in vivo towards NF-κB-mediated inflamm…
  pubmed Scholtz CR, Doskey LC, Kandanur SGS, Vail NR 等 2026 Feb 15 置信度 0.82
• Inhibitors of GapN-dependent NADPH supply as potential lead compounds for novel therapeutics against Streptococcus pyogenes.
  Infections with Streptococcus pyogenes are among the most important diseases caused by bacteria and are responsible for around 500,000 deaths every year. In 2024, macrolide-resistant S. pyogenes was added to the WHO's list of priority pathogens. The non-phosph…
  pubmed Schütt I, Einwohlt P, Wandinger AM, Teuffel J 等 2026 Dec 置信度 0.82
• Histone lysine demethylases in breast cancer: molecular mechanisms, biological functions, and therapeutic intervention.
  Breast cancer is a highly heterogeneous disease characterized by diverse molecular subtypes and complex pathogenesis. Recent advances in epigenetics have unveiled the crucial roles of lysine demethylases (KDMs) in modulating gene expression and chromatin dynam…
  pubmed Wang A, Qi D, Ma Y, Wang M 等 2025 Dec 23 置信度 0.82
• Optimal accompanying diagnosis design through external validation of population pharmacokinetic models for moxifloxacin in tuberculosis patients.
  BACKGROUND: We aimed to design an optimal accompanying diagnosis, defined as a model-informed limited sampling strategy (LSS) that uses validated population pharmacokinetic (popPK) models to predict moxifloxacin exposures with minimal blood samples, facilitati…
  pubmed Lee H, Jung W, Chang MJ, Lee S 等 2025 Dec 24 置信度 0.82
• A retrospective analysis of liver dysfunction and its risk factors in lung cancer patients receiving PD-1/PD-L1 inhibitor therapy.
  Primary lung cancer remains one of the most common and lethal malignancies worldwide, with especially high incidence and mortality in China. Although advancements in targeted therapies and immunotherapy have significantly improved patient outcomes, immune-rela…
  pubmed Xia Y, Jiang Z, Huang B, Zhang J 等 2025 Dec 19 置信度 0.82
• Association between glucagon-like peptide-1 receptor agonists and risk of dementia in older adults with type 2 diabetes: A target trial emulation.
  Type 2 diabetes (T2D) is associated with increased dementia risk, but comparative data across newer glucose-lowering therapies remain limited. We examined whether the initiation of GLP-1 receptor agonists (GLP-1 RAs) was associated with incident dementia compa…
  pubmed Zhou T, Tang H, Zhang B, Zhang D 等 2026 Mar 置信度 0.82
• Treatment outcomes in Mycobacterium abscessus pulmonary disease: A systematic review.
  Mycobacterium abscessus complex (MABC) is an emerging global threat due to its intrinsic and acquired resistance to many antibiotics, making treatment particularly challenging. This systematic review aimed to evaluate current treatment regimens and clinical ou…
  pubmed Lim AYH, Pethe K, Khoong CHL, Dedon P 等 2025 Nov 4 置信度 0.82
• Whole genome sequencing and genomic characterization of the extensively drug-resistant Acinetobacter baumannii recovered from clinical samples in Lahore, Pakistan.
  Extensively drug-resistant (XDR) Acinetobacter baumannii has turned into a significant nosocomial pathogen often resistant to all available classes of antibiotics. It has been identified as a key public health issue due to its capacity to get resistance determ…
  pubmed Rehman T, Sharif A, Khalid L, Sajid I 2025 Dec 19 置信度 0.82
• Tre-DST: A Drug Susceptibility Test for Mycobacterium tuberculosis Using Solvatochromic Trehalose Probes.
  In 2024, an estimated 10 million people developed Tuberculosis (TB), nearly half a million of whom were infected with drug-resistant tuberculosis (DR-TB). Early detection of infection and drug resistance enables rapid engagement in effective care. Bacterial cu…
  pubmed Schwartz LA, Brodeth AL, Susilo CT, Rodolf AA 等 2026 Jan 9 置信度 0.82
• The persistent chasm between PrEP awareness and uptake: characterizing the biomedical HIV prevention continuum in a nationwide cohort of transgender women in the United States and Puerto Rico.
  Transgender (trans) women are disproportionately impacted by HIV, yet data on the biomedical HIV PrEP continuum (HIVPC) among trans women are limited. We characterized the HIVPC among a large, nationwide cohort of trans women in the United States and Puerto Ri…
  pubmed Cooney EE, Poteat TC, Stevenson M, Radix AE 等 2025 Dec 置信度 0.82
• Current Applications and Future Challenges of Mesenchymal Stem Cell-Extracellular Vesicles in Tissue Engineering: A Bibliometric Analysis.
  Extracellular vesicles derived from mesenchymal stem cells (MSCs-EVs) are nano-sized vesicles and have become key mediators in tissue engineering and emerging therapeutic agents in regenerative medicine. This study systematically assessed the global research t…
  pubmed Chen S, Di J, Zhang Z, Guo Z 等 2025 置信度 0.82
• Inflammation and Hemoglobin Oxygen Affinity.
  In septic patients, oxygen delivery is often impaired, yet the specific impact of inflammation on erythrocyte oxygen transport characteristics remains largely unexplored. This study examined the direct effects of endotoxin-induced inflammation on the oxygen di…
  pubmed Staier N, Mair N, Frisch C, Oberacher H 等 2025 Dec 18 置信度 0.82
• Pharmacological Inhibition of NF-κB in Mesenchymal Stromal Cells Selectively Partitions Apoptosis-Inducing Factors in Their Microvesicles and Proliferation-Inducing Factors in Their Exosomes: Implications in the Management of Acute Myeloid Leukemia.
  We previously showed that inhibition of the NF-κB signaling pathway in mesenchymal stromal cells (MSCs) (NKI-MSCs) induces quiescence in co-cultured hematopoietic stem cells (HSCs). This led us to investigate whether NKI-MSCs exert similar growth-inhibit…
  pubmed Pendse S, Chavan S, Kasherwal V, Kale V 等 2026 Jan 置信度 0.82
• A decade of ibrutinib for CLL with and without TP53 aberration: final report on an investigator-sponsored phase 2 study.
  Bruton tyrosine kinase inhibitors improve outcomes for patients with chronic lymphocytic leukemia (CLL). Long-term data with continuous therapy are limited. With a median follow-up of 10.0 years, we report final results on 84 patients with TP53 aberrations (de…
  pubmed Itsara A, Rogness VM, Samples L, Yuan CM 等 2026 Apr 9 置信度 0.82
• Functional and therapeutic effects of Glabrescione B delivery by liposomes on Hedgehog-dependent tumors.
  Aberrant Hedgehog (HH) signaling pathway is responsible of tumorigenesis of medulloblastoma (MB) and basal cell carcinoma (BCC), two aggressive malignancies with limited therapeutic options. Targeting Gli1, the final and powerful effector of HH signaling, emer…
  pubmed Infante P, Daniele R, Bottero M, Longo M 等 2026 Jul 置信度 0.82
• Antimalarial potential of curcumin derivatives evaluated through experimental and computational approaches.
  Malaria remains a leading global health threat, with cases and deaths continually increasing each year. The rising number of drug-resistant cases further diminishes the effectiveness of current antimalarials, highlighting the need for potent and effective new …
  pubmed Jamil SNH, Bakar KA, Ali AH, Marzuki NFN 等 2025 Dec 15 置信度 0.82
• Apatinib-Induced STAT1/NK axis activation augments PD-1 inhibitor efficacy in advanced Hepatocellular Carcinoma.
  The combination of immune checkpoint inhibitors (ICIs) with anti-angiogenic agents has demonstrated efficacy in the clinical treatment of advanced hepatocellular carcinoma (HCC). This study seeks to elucidate the underlying mechanisms that contribute to the en…
  pubmed Cui LS, Wei MR, Fu J, Guo JR 等 2025 Dec 16 置信度 0.82
• Molecular intelligence and immune reconnaissance in thyroid cancer: a new paradigm for diagnosis, risk stratification, and therapeutic precision.
  Thyroid cancer management is shifting from morphology-based assessment to precision oncology driven by integrated molecular profiling and computational analytics. This review examines how these advances address overdiagnosis, indeterminate cytology, and radioi…
  pubmed Concepción-Zavaleta MJ, Fuentes-Mendoza JM, Cruz-Quintá A, Cadena-Guerrero AV 等 2026 May 置信度 0.82
• Antiviral susceptibility of clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) viruses from humans in the United States, October 2024 to February 2025.
  Since October 2024, 55 human cases of influenza A(H5N1), clade 2.3.4.4b, were reported in the US. Sequencing of 46 viruses identified genotypes B3.13, D1.1, and D1.3. Virus genomes were analyzed for mutations associated with reduced antiviral susceptibility. E…
  pubmed Pascua PNQ, Chesnokov AP, Nguyen HT, Champion C 等 2026 Dec 置信度 0.82
• A non-spike nucleocapsid R204P mutation in SARS-CoV-2 Omicron XEC enhances inflammation and pathogenicity.
  The global circulation of SARS-CoV-2 in human populations has driven the emergence of Omicron subvariants, which have become highly diversified through recombination. In late 2024, SARS-CoV-2 Omicron XEC variant emerged from the recombination of two JN.1 proge…
  pubmed Tsujino S, Tsuda M, Deguchi S, Ito J 等 2025 Dec 14 置信度 0.82
• ESMO-ESTRO consensus statements on the safety of combining radiotherapy with CDK4/6, HER2, PARP, or mTOR inhibitors.
  While combining radiotherapy (RT) with targeted agents or immunotherapy may improve outcomes, it may also increase toxicity. High-quality toxicity data and multidisciplinary, evidence-based guidelines on the combination of these treatment modalities are scarce…
  pubmed van Aken ESM, Gandhi AK, O'Cathail SM, Borst G 等 2026 Feb 置信度 0.82
• Structure-Based Development of Ultra-Broad-Spectrum 3C-Like Protease Inhibitors.
  Recurrence of coronavirus outbreaks and zoonotic origins of human coronaviruses underscore the importance of developing pan-coronavirus antivirals. The highly conserved 3C-like protease (3CL pro ) in coronaviruses, together with the well-established druggabili…
  pubmed Su H, Nie T, Chen G, Xiong M 等 2026 Feb 置信度 0.82
• New Terpenoids from the Soft Coral Sarcophyton trocheliophorum and Their Anti-inflammatory Activities.
  A detailed chemical investigation of the Hainan soft coral Sarcophyton trocheliophorum led to the isolation of three new cembrane-type diterpenoids (sartrocheliols F-H), one new aromadendrane-type sesquiterpenoid (sartrocheliol I), a new natural cembranoid, an…
  pubmed An SH, Feng X, Lu TT, Shen SM 等 2026 Feb 置信度 0.82
• Natural compound-nanoparticle therapies for breast cancer: A review from 2018-2025.
  Breast cancer (BC) poses significant global challenges due to drug resistance, toxicity, and subtype heterogeneity. Some plant derived natural compounds show multi-target anticancer potential but suffer from poor bioavailability and rapid metabolism. To overco…
  pubmed Zhang X, Fei G, Xiujia S, Ganesan K 等 2026 Jan 置信度 0.82
• Lipophilic Substances of the Leaves and Inflorescences of Centaurea scabiosa L.: Their Composition and Activity Against the Main Protease of SARS-CoV-2.
  The composition of the lipophilic components of Centaurea scabiosa L. has been studied. The raw material was subjected to extraction with hexane and methyl tert-butyl ether (MTBE) using both exhaustive and sequential schemes for a detailed characterization. Th…
  pubmed Kukina TP, Elshin IA, Marenina MK, Kolosova EA 等 2025 Nov 27 置信度 0.82
• Targeting gasdermin D-mediated pyroptosis: a precision anti-inflammatory strategy for acute and chronic lung diseases.
  Gasdermin D (GSDMD) is currently considered the major effector of pyroptosis, a lytic proinflammatory programmed cell death, which mediates pathogenesis in numerous inflammatory lung diseases, such as acute respiratory distress syndrome (ARDS), chronic obstruc…
  pubmed Samuel VP, Afzal M, Babu MA, Malathi H 等 2026 Jan 置信度 0.82
• The impact of artificial intelligence-driven decision support on uncertain antimicrobial prescribing: a randomised, multimethod study.
  Challenges exist when translating artificial intelligence (AI)-driven clinical decision support systems (CDSSs) from research into health-care settings, particularly in infectious diseases, an area in which behaviour, culture, uncertainty, and frequent absence…
  pubmed Bolton WJ, Wilson R, Gilchrist M, Georgiou P 等 2025 Nov 置信度 0.82
• Treatment Patterns in Patients With Incident Pulmonary Hypertension: Real-World Data From the Pulmonary Hypertension Association Registry.
  Current evidence supports risk-based treatment for pulmonary arterial hypertension (PAH) with an endothelin receptor antagonist and phosphodiesterase type 5 inhibitor as initial therapy for patients with low- and intermediate-risk PAH, and triple therapy with …
  pubmed Khan SL, Paoli CJ, Kime N, Williams K 等 2026 Apr 置信度 0.82
• Evaluating Generative AI Psychotherapy Chatbots Used by Youth: Cross-Sectional Study.
  Many youth rely on direct-to-consumer generative artificial intelligence (GenAI) chatbots for mental health support, yet the quality of the psychotherapeutic capabilities of these chatbots is understudied.
  pubmed Sobowale K, Humphrey DK, Zhao SY 2025 Dec 10 置信度 0.82
• Botulinum Toxin for Refractory Vaginismus: A Therapeutic Evaluation of a Rare and Under-Researched Condition.
  Vaginismus is a rare and under-researched psychosexual disorder characterized by involuntary vaginal muscle contractions that impede penetration, causing significant distress. Despite its impact, large-scale studies remain scarce. This study, one of the larges…
  pubmed Konac A, Yıldız M 2025 Dec 10 置信度 0.82
• Targeting fibroblast activation protein in solid tumors via LNP-mediated CAR-mRNA delivery promotes durable regression in murine models.
  The therapeutic potential of chimeric antigen receptor (CAR) T-cell therapy in treating solid tumors is highly recognized, yet the complex and immunosuppressive nature of the tumor microenvironment, poor accessibility, and the instability of target antigens po…
  pubmed Meng S, Hara T, Sato T, Tatekawa S 等 2025 Dec 10 置信度 0.82
• Monitoring the plasma concentration of ripretinib and its metabolites in Chinese patients with gastrointestinal stromal tumors in a real-life setting.
  Although therapeutic drug monitoring is crucial for the comprehensive management of gastrointestinal stromal tumors (GISTs), the relationship between plasma concentration of ripretinib and its therapeutic efficacy is unknown. This study aimed to explore the re…
  pubmed Zhang Q, Li F, Wang F, Zhou Y 等 2025 Dec 1 置信度 0.82
• HBV Reactivation in Patients with Hepatocellular Carcinoma Treated with PD-1/-L1 Antibodies and Concurrent Antiviral Prophylaxis Agents: A Prospective Observational Study.
  Immune checkpoint inhibitor (ICI)-related trials in hepatocellular carcinoma (HCC) have strict restrictions on hepatitis B (HBV) DNA load because of HBV reactivation. This study aimed to compare the HBV reactivation between patients with HCC with low or high H…
  pubmed Du Z, Lai Z, Huang Y, Chen H 等 2026 Feb 17 置信度 0.82
• Cutaneous Adverse Effects of EGFR Therapy in Breast Cancer Treatment.
  Breast cancer is among the most common cancers in U.S. women. Epidermal growth factor receptor inhibitors (EGFRIs) target pathways driving tumor growth but frequently cause dermatologic toxicities that impact quality of life and treatment adherence. This revie…
  pubmed Devireddy T, Lim C, Patel J, Tan IJ 等 2025 Dec 置信度 0.82
• Tinengotinib for adults with advanced or metastatic cholangiocarcinoma: a multicentre, open-label, phase 2 trial.
  Cholangiocarcinoma is a rare, aggressive cancer often driven by FGFR2 fusions, which are targetable with inhibitors such as pemigatinib and futibatinib. However, resistance frequently develops due to acquired FGFR2 mutations. In this study, we aimed to evaluat…
  pubmed Javle M, Fountzilas C, Liao CY, Pelster M 等 2026 Feb 置信度 0.82
• Reinforcement learning with low-rank adaptation for targeted antimicrobial peptide design.
  Antimicrobial peptides (AMPs) are emerging as promising alternatives to traditional antibiotics, offering solutions to antimicrobial resistance through diverse mechanisms. Despite their potential, current computational approaches for AMP design rarely address …
  pubmed Park J, Bae D, Bae B, Nam H 2025 Nov 1 置信度 0.82
• Metabolomics Study and Evaluation of Antioxidant and Anti-Inflammatory Activities of Essential Oils From Rosa rubus (Blackberry Rose).
  Many species of the genus Rosa were renowned for their high ornamental or edible value. Among them, Rosa rubus, a native species in China, boasts a pleasant aroma of its flowers that distinguishes it from roses, offering significant potential for further explo…
  pubmed Chen Q, Chen JL, Huang HY, Huang LJ 等 2026 Feb 置信度 0.82
• Updates in antithrombotic therapy in coronary and peripheral artery disease.
  Atherosclerotic cardiovascular disease (ASCVD) encompasses a spectrum of vascular conditions, including coronary artery disease (CAD) and lower extremity peripheral artery disease (PAD), which frequently coexist. In the setting of ASCVD, there is a common unde…
  pubmed Pollak AW 2025 Dec 5 置信度 0.82
• The promise of menin inhibitors: from approval to triplet regimens.
  Pharmacologic targeting of the menin-KMT2A protein-protein interaction has emerged as a therapeutic breakthrough for acute leukemias harboring KMT2A rearrangements or NPM1 mutations. The first-in-class menin inhibitor (revumenib) achieved accelerated regulator…
  pubmed Thakur RK, Wang ES 2025 Dec 5 置信度 0.82
• Potential therapeutic targeting of BK(Ca) channels in glioblastoma treatment.
  Potassium channels in brain tissue orchestrate essential cellular processes, including the regulation of membrane potential and neuronal excitability. Among them, large-conductance calcium-activated potassium (BK Ca ) channels play a pivotal role in both norma…
  pubmed Maliszewska-Olejniczak K, Pytlak K, Jaworowska S, Kulawiak B 等 2026 Jun 置信度 0.82
• Hetrombopag for thrombocytopenia induced by concurrent or sequential chemoradiotherapy in patients with solid tumors: a double-cohort trial.
  BACKGROUND: Chemoradiotherapy-induced thrombocytopenia (CRT-IT) is a common and clinically significant complication in cancer patients, yet there are no severity-based treatment guidelines, and existing therapies are limited by safety concerns and practicality…
  pubmed Cheng Y, Zhai C, Wang Q, Ai J 等 2025 Dec 4 置信度 0.82
• The Extended Safety and Efficacy of Indobufen in Conjunction With P2Y12 Receptor Inhibitors Among Patients Undergoing Revascularization: A Meta-Analysis and Overview.
  Dual antiplatelet therapy (DAPT), which combines aspirin with a P2Y12 receptor inhibitor for platelets, is crucial for the prevention of cardiac and systemic ischemic events in patients with coronary artery disease who have undergone revascularization procedur…
  pubmed Yi M, Cao Q, Sheng YH, Wu L 等 2025 置信度 0.82
• Targeting the deSUMOylase Ulp2 in Candida glabrata for antifungal therapies: in silico identification of silymarin and honokiol as potential inhibitors.
  Fungal infections, especially those caused by naturally drug-resistant strains such as Candida glabrata, present a significant global health concern due to the limitations of existing antifungal treatments, which are often compromised by toxicity and resistanc…
  pubmed Gupta D, Andole S, Mishra K 2025 Dec 3 置信度 0.82
• Inhibitor of hyaluronic acid synthesis 4-methylumbelliferone (4-MU) as a potential anti-inflammatory substance in acute neuroinflammation model in vivo.
  Cytokine and oxylipin profiles in rat brain homogenates were characterized as an inflammatory response 6 h after a single intracerebroventricular injection of LPS (19.3 µg LPS/ventricle), serving as a model of the inflammatory process in trauma,…
  pubmed Chistyakov DV, Nikolskaya AI, Gorbatenko VO, Goriainov SV 等 2026 Jan 置信度 0.82
• Virtual reality and cheminformatics-driven discovery of a potential broad-spectrum natural antagonist against flaviviral methyltransferases and its cytotoxicity evaluation.
  The alarming rise in flaviviruses like Zika virus (ZikV) and dengue virus (DenV) has made them a major global health concern, especially in tropical and subtropical regions where nearly half of the global population is at risk. The urgency for safe and effecti…
  pubmed Thomas J, Kumar R, Satija J 2025 Dec 3 置信度 0.82
• Safety profile of TNF- alpha Inhibitors in pediatric patients: A post-marketing surveillance study based on the FAERS database.
  This study systematically evaluated the safety profile of tumor necrosis factor-alpha (TNF-α) inhibitors in pediatric patients using data from the U.S. Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) from Q1 2004 to Q3 2024.Thro…
  pubmed Yang Y, Wang P, Li QX 2025 置信度 0.82
• Telemedicine Preexposure Prophylaxis Prescribing From a Large Online US Company.
  HIV preexposure prophylaxis (PrEP) is highly effective in HIV prevention; telemedicine is a promising avenue for delivering PrEP care.
  pubmed Siegler AJ, Koh SHE, Schukraft T, Mazzoni S 等 2025 Dec 1 置信度 0.82
• An evaluation of guselkumab for the treatment of ulcerative colitis.
  Interleukin (IL)-23 is a cytokine implicated in the pathogenesis of ulcerative colitis (UC). Guselkumab, a selective IL-23 antagonist, was approved for the treatment of moderately-to severely active UC in 2024/5.
  pubmed Hanzel J, Jairath V, Feagan BG 2025 Nov 置信度 0.82
• Molecular basis for a pore block of Tentonin 3 expressed in HEK293 cells by a conopeptide, NMB-1.
  Tentonin 3 (TTN3/TMEM150C) is a mechanosensitive ion channel that plays critical roles in mechanotransduction processes. TTN3 forms a tetramer with a predicted rectangular shape and a central pore. A conotoxin ρ-TIA and its synthetic analog, noxious mech…
  pubmed Lim S, Woo J, Pak S, Paik J 等 2026 May 置信度 0.82
• No Effect of Low-Dose Aspirin Versus Placebo as Add-On Treatment in Bipolar Disorder-Results From a Randomised Controlled Trial (the A-Bipolar RCT).
  Robust evidence associates immunoinflammatory dysfunction and bipolar disorder (BD), with immune dysregulation present in patients newly diagnosed with BD. This suggests that anti-inflammatory agents, like low-dose aspirin (LDA), might be repurposed in the tre…
  pubmed Bruun CF, Krogh HB, Zarp J, Stokholm JR 等 2026 Mar 置信度 0.82
• A retrospective analysis of influence of the establishment of intelligent hypertension diagnosis and treatment center on blood pressure data management and treatment compliance of patients with hypertension in Sichuan, China, and its clinical value in accurate diagnosis and treatment.
  This research is aimed to retrospectively evaluate the benefits of competent hypertension diagnosis and treatment centers in managing blood pressure data and therapy concerns in hypertension patients in Sichuan, China.
  pubmed Xie D, Guo J, Sun X, Zhong P 2025 Nov 29 置信度 0.82
• Targeting RNA polymerase I to boost natural killer cell anticancer activity in multiple myeloma.
  Multiple myeloma (MM) remains an incurable disease despite therapeutic advancements extending survival. Relapses driven by drug resistance and minimal residual disease underscore the need for novel treatment strategies. Natural Killer (NK) cells play a key rol…
  pubmed Sproviero E, Gnocchini E, Cipollone T, Petillo S 等 2025 Nov 28 置信度 0.82
• Patient Preferences in Anticoagulation Treatment: A Review of Discrete Choice Experiments.
  Patient engagement is expected to improve the safety and efficacy of anticoagulant medication. By identifying the factors and patient characteristics influencing patients' decisions regarding anticoagulant medication, we aim to support healthcare professionals…
  pubmed Brugman IM, van Eikenhorst L, Schlinkert C, Wagner C 2026 May 置信度 0.82
• Impact of storage on the stability and the protective effect of extracellular vesicles released by Candida albicans.
  Extracellular vesicles (EVs) released by Candida albicans are multi-antigenic compartments considered as promising prototypes for vaccine development. However, their stability, appropriate storage, and handling conditions are largely unexplored, which raises q…
  pubmed Honorato L, Bonilla JJA, Valdez AF, Reis FCd 等 2025 Dec 23 置信度 0.82
• Dual-drug-loaded carbopol gel for enhanced oral wound healing: a curcumin-ciprofloxacin-based therapeutic approach.
  Chronic oral wounds are prone to infection and delayed healing, necessitating therapeutic gels that combine antimicrobial and regenerative functions.
  pubmed Senthil R, R PK, Sravanthy PG 2025 Nov 28 置信度 0.82
• Healthbots for conducting clinical screening and remote monitoring with patient mood assessment: A scoping review.
  Patient mood assessment is key in managing chronic diseases but is often overlooked. Although conversational agents enhance telemonitoring and engagement, few healthbots incorporate automated mood analysis into routine clinical workflows or hybrid care. The ri…
  pubmed Cesar Abrantes P, Netto AV, Kazuo Takahata A 2026 Mar 1 置信度 0.82
• Global burden of TNF-α inhibitors associated demyelinating diseases: A global disproportionality analysis.
  Despite case reports linking tumor necrosis factor-alpha (TNF-α) inhibitors to demyelinating diseases, large-scale epidemiological evidence is limited. We aimed to investigate this signal detection using a global pharmacovigilance database. This study id…
  pubmed Kim TH, Park J, Jo H, Oh J 等 2025 Nov 21 置信度 0.82
• Clinical Outcomes of COPD Patients Hospitalized for SARS-Cov-2 Infection During the Omicron Era: Comparative Effectiveness of Initiating Remdesivir in Addition to Corticosteroids Versus Corticosteroids Alone.
  Patients with chronic obstructive pulmonary disease (COPD) are vulnerable to developing severe SARS-CoV-2 infection. This retrospective study evaluated the effectiveness of remdesivir (RDV) initiated with corticosteroids (CCS) versus CCS only in patients with …
  pubmed Ahuja N, Jiang H, Milano M, Casciano R 等 2025 Oct 29 置信度 0.82
• Assessing the Influence of Proton Pump Inhibitors on Clinical Outcomes in Hormone Receptor-Positive Metastatic Breast Cancer Patients Receiving CDK4/6 Inhibitors: Evidence from a Ribociclib-Dominant Cohort.
  Background and Objectives : Endocrine therapy combined with CDK4/6 inhibitors are widely recognized as the standard first-line approach for treating hormone receptor-positive HER2-negative (HR+/HER2-) metastatic breast cancer (mBC). Nonetheless, potential phar…
  pubmed Erul E, Öksüz NE, Akkus E, Tolunay PK 等 2025 Oct 31 置信度 0.82
• The Genetic and Embryo-Fetal Developmental Toxicity Profile of the Novel Transgelin Agonist Deg-AZM: Ames, Micronucleus, Chromosomal Aberration, and Rat EFD Studies.
  Background: Slow-transit constipation (STC) lacks durable and safe prokinetics. Deglycosylated-azithromycin (Deg-AZM), a novel small-molecule transgelin agonist that restores colonic motility in STC, has been approved for clinical trials in 2024. Objectives: T…
  pubmed Gu X, Xu Y, Liu N, Li K 等 2025 Oct 23 置信度 0.82
• Factorized embedding of goal and uncertainty in the lateral prefrontal cortex guides stably flexible learning.
  A major challenge for adaptive agents is achieving behavioral flexibility without compromising stability-particularly in goal-directed learning within uncertain environments. Agents must adjust as goals shift while maintaining resilience against noisy signals,…
  pubmed Sung Y, Rigotti M, Lee SW 2025 Nov 26 置信度 0.82
• Baicalin ameliorates interstitial cystitis/bladder pain syndrome by inhibiting the TLR4/NF-κB pathway.
  Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic inflammatory bladder disorder characterized by pelvic pain and urinary symptoms, yet effective therapeutic options remain limited. Baicalin (BA), a bioactive flavonoid derived from Scutellaria b…
  pubmed Yang D, He Y, Alimu P, Cao D 等 2026 Mar 置信度 0.82
• Self-assembled phenylboronic acid nanomedicine targets sialic acid to synergistically activate ferroptosis via RRM1 suppression and GPX4 Inhibition for precision colon cancer therapy.
  Despite the promise of ferroptosis in cancer therapy, its insufficient potency and off-target toxicity remain significant challenges. Few studies have explored the therapeutic potential of nanoparticle (NP)-mediated active targeting strategies to induce robust…
  pubmed Song D, Li J, Zhu Y, Hui Q 等 2025 Nov 25 置信度 0.82
• Discovery of a Proteolysis Targeting Chimera for TRKA and RET-derived oncoproteins.
  We designed Proteolysis Targeting Chimeras (PROTACs) to target Tropomyosin Receptor Kinase A (TRKA) and Rearranged during Transfection (RET) oncogenic proteins. We analyzed a series of 22 PROTACs, based on the RET and TRKA small molecule inhibitor Pz-1 and lig…
  pubmed Moccia M, Zhang L, Wang Z, Wang M 等 2025 Nov 25 置信度 0.82
• Association Between Adipose Tissue Distribution and Survival in Recurrent Ovarian Cancer Patients Treated With Anti-VEGF Therapy: A Retrospective CT-Based Analysis.
  The aim of this study was to evaluate the effect of visceral, subcutaneous and intermuscular adipose tissue areas measured by computed tomography at diagnosis on survival in ovarian cancer patients receiving second-line bevacizumab treatment.
  pubmed Cokgezer S, Senkal M, Safaraliyeva A, Kose H 等 2025 Nov 置信度 0.82
• Beyond Algorithms: Machine Learning and Clinical Determinants of Voriconazole Plasma Levels in Therapeutic Drug Monitoring.
  Voriconazole is a broad-spectrum antifungal agent whose efficacy and toxicity are closely related to plasma concentrations, which are highly variable between individuals. Therapeutic drug monitoring (TDM) helps optimize its use but is not always available. In …
  pubmed Maray I, Orallo C, Eiora-Osoro M, Oyague L 等 2026 Jan 置信度 0.82
• Language adaptations of mental health interventions: User interaction comparisons with an AI-enabled conversational agent (Wysa) in English and Spanish
  Background In recent times, digital mental health interventions (DMHIs) have been proven to be efficacious; however, most are available only for English speakers, leaving limited options for non-English languages like Spanish. Research shows that mental health…
  crossref Dyuthi Nirupama Dinesh, M Namrata Rao, Chaitali Sinha 2024-05-24T04:17:50Z 置信度 0.70
• Empowering Scientific Research with Nextflow + AI
  crossref 2024-12-10T11:23:03Z 置信度 0.70
• Simulating the Economic Impact of Rationality through Reinforcement Learning and Agent-Based Modelling
  Agent-based models (ABMs) are simulation models used in economics to overcome some of the limitations of traditional frameworks based on general equilibrium assumptions. However, agents within an ABM follow predetermined ‘bounded rational’ behavioural rules wh…
  crossref Simone Brusatin, Tommaso Padoan, Andrea Coletta, Domenico Delli Gatti 等 2024-11-14T06:38:06Z 置信度 0.70
• Agent-Based Autonomous Robotic System Using Deep Reinforcement and Transfer Learning
  crossref Vladyslav Kyryk, Maksym Figat, Marian Kyryk 2024-07-29T08:02:19Z 置信度 0.70
• Enhancing Precision and Efficiency in Study Identification: A Human-AI Collaborative Approach with Domain Knowledge Expertise
  crossref Flavien Owolabi 2026-01-02T01:35:55Z 置信度 0.70
• Self-Aware Intelligent Medical Rescue Unmanned Team via Large Language Model and Multi-Agent Reinforcement Learning
  Abstract: The evolution of medical rescue operations from traditional to future scenarios demands innovative approaches to intelligent automation. This paper proposes a self-award medical rescue team, leveraging cutting-edge technologies such as Large Language…
  crossref Xuejiao Wang, Guoqing Zhi, Zhihao Tang, Hao Jin 等 2025-07-17T11:26:39Z 置信度 0.70
• Cyber Resilience of IIoT Network Assets Using Multi-agent AI Against Advanced Persistent Threat
  crossref Arulkumar Diana, K. Kartheeban 2024-09-18T14:21:04Z 置信度 0.70
• AI-Enhanced Security Architecture for 6G Networks: A Federated Learning and Multi-Agent Approach
  The coming 6G network is expected to provide better connectivity and network performance but will generate new security challenges. In this paper, we demonstrate a novel technological solution to address the security challenges of the 6G network by combining a…
  crossref V.V Teresa, J. Dhanaseker, S Arjun, R Naveenraj 等 2025-03-18T17:31:46Z 置信度 0.70
• From Data to Story: Towards Automatic Animated Data Video Creation with LLM-Based Multi-Agent Systems
  Creating data stories from raw data is challenging due to humans' limited attention spans and the need for specialized skills. Recent advancements in large language models (LLMs) offer great oppor-tunities to develop systems with autonomous agents to streamlin…
  crossref Leixian Shen, Haotian Li, Yun Wang, Huamin Qu 2024-11-26T18:45:54Z 置信度 0.70
• Encoding Agent Trajectories as Representations with Sequence Transformers
  Spatiotemporal data faces many analogous challenges to natural language text including the ordering of locations (words) in a sequence, long range dependencies between locations, and locations having multiple meanings. In this work, we propose a novel model fo…
  crossref Athanasios Tsiligkaridis, Nicholas Kalinowski, Zhongheng Li, Elizabeth Hou 2024-11-18T06:23:21Z 置信度 0.70
• CISFA: A Decision-Support Agent Framework and its Allied Implementation with Generated AI in Oil and Gas Industry
  With a rapid development of artificial intelligence generative content (AIGC), a set of human-machine interactive models have been changed. However, with limited understanding of the purposes of industry, even though fined-tuned by the professional data. The m…
  crossref Hongzhi Chen, Wei Jin, Xiufeng Lin 2024-06-17T09:30:37Z 置信度 0.70
• AI-Powered Multi-Agent Framework for Automated Unit Test Case Generation: Enhancing Software Quality through LLM’s
  Recent years have witnessed an enormous rise in the design, repair and the enhancement of software automation tests. The reliability of program’s unit testing has major impact on its overall performance. The anticipated influence of Artificial Intelligence adv…
  crossref Anusha Garlapati, M N V Satya Sai Muni Parmesh, Savitha, Jaisri S 2025-03-21T15:05:39Z 置信度 0.70
• Diversity of Thought Elicits Stronger Reasoning Capabilities in Multi-Agent Debate Frameworks
  Large language models (LLMs) excel in natural language generation but often confidently produce incorrect responses, especially in tasks like mathematical reasoning. Chain-of-thought prompting, self-verification, and multi-agent debate are among the strategies…
  crossref Mahmood Hegazy 2025-01-13T06:12:48Z 置信度 0.70
• Ethical and Responsible AI: Governance Frameworks and Policy Implications for Multi-Agent Systems
  Semi-autonomous, augmented- Artificial Intelligence has become increasingly relevant as collective activities are practiced by two or more autonomic entities. MAS and AI at the intersection have fostered very new waves of socioeconomic exchange, necessitating …
  crossref Tejaskumar Pujari, Anshul Goel, Ashwin Sharma 2025-04-28T01:27:44Z 置信度 0.70
• Agentic AI Framework for Personalized Learning in Higher Education: A Multi-Agent Approach for Adaptive Student Support
  The increasing adoption of Artificial Intelligence (AI) in higher education has transformed the delivery of learning experiences, enabling institutions to move beyond traditional one-size-fits-all instructional approaches.Personalized learning has emerged as a…
  crossref Medhunhashini DR 2026-06-15T07:01:38Z 置信度 0.70
• Unlocking AI Creativity: A Multi-Agent Approach with CrewAI
  By automating processes that traditionally require human intelligence, such as learning, reasoning, and problem-solving, Artificial Intelligence (AI) has transformed many industries. Even with these developments, System 1 thinking is quick, providing instincti…
  crossref P. Venkadesh, S. V. Divya, K. Subash Kumar 2024-10-22T06:55:34Z 置信度 0.70
• A forensic artifact survey of conversational AI services and AI agent browsers across multiple platforms
  crossref Wonjun Ma, Kyeongwoo Park, Seokhyun Hong, Yeongpil Cho 2026-08-19T09:02:16Z 置信度 0.70
• Dynamic Agent Affiliation: Who Should the AI Agent Work for in the Older Adult's Care Network?
  The population of older adults experiencing cognitive decline is growing faster than the number of workers who can care for them. Artificially intelligent (AI) agents could assist these older adults, keeping them in their homes longer. For this to happen, olde…
  crossref Mai Lee Chang, Alicia (Hyun Jin) Lee, Nara Han, Anna Huang 等 2024-06-29T18:48:34Z 置信度 0.70
• Memory-Augmented Agent Training for Business Document Understanding
  crossref Jiale Liu, Yifan Zeng, Malte Højmark-Bertelsen, Marie Normann Gadeberg 等 2026-01-02T01:46:58Z 置信度 0.70
• Secret Collusion among AI Agents: Multi-Agent Deception via Steganography
  crossref Sumeet Motwani, Mikhail Baranchuk, Martin Strohmeier, Vijay Bolina 等 2025-11-03T11:20:56Z 置信度 0.70
• Editorial: AI as intelligent technology and agent to understand and be understood by human minds
  The rapid evolution of artificial intelligence (AI) is profoundly reshaping our lives and work, demonstrating significant potential in areas such as industrial automation, business operations, academic research, and daily applications (Arin, 2023). However, th…
  crossref Hao Chen, Xiaopeng Ren, Lingnan He, Junming Huang 2024-10-10T11:56:03Z 置信度 0.70
• Application of AI conversation agent in new frameworks and fields and improvement in sensory aspects
  Taking a big step with the development of AI, the functions of conversation agents are becoming increasingly mature, and people's lives are becoming increasingly dependent on the conversation agent system. Its assistance to people is reflected in many fields. …
  crossref Yaxuan Liang, Yun Ye, Enhao Zhu 2024-02-23T01:44:22Z 置信度 0.70
• AI-Powered Animal Recognition and Tracking via Drone-Based Thermal Imaging: A User-Centric Mobile Application
  The integration of AI-powered drone monitoring with thermal imaging cameras enhances wildlife protection by enabling autonomous animal detection and classification. This paper presents a system based on YOLOv8 that processes thermal data from drones, allowing …
  crossref Julia Hermann, Lukas Wedemeyer, Yakup Topac, Jonas Hoffmann 等 2024-11-20T00:24:28Z 置信度 0.70
• Design and Evaluation of an AI-Powered Conversational Agent for Personalized Mental Health Support and Intervention (MindBot)
  This research study describes the design and evaluation of an interactive MindBot to help a person deal with depressive Sentiments and to support individuals experiencing depressive symptoms by providing timely, interactive, and empathetic engagement. With the…
  crossref Shweta M. Kambare, Kriya Jain, Ishika Kale, Vibhor Kumbhare 等 2025-02-10T18:28:30Z 置信度 0.70
• Enhanced SDN Security Using Mobile Agent
  In the next-generation trend, Software-Defined Networking (SDN) is a revolutionary paradigm of network technology that enables advanced network features such as centralized network flow and programmability to facilitate network deployment which is more adaptab…
  crossref Nguyen Minh Phuc, Nguyen Ai Viet, Tran Quy Nam, Long Cu Kim 等 2024-08-30T21:34:39Z 置信度 0.70