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• A rank-2 Euler system prototype for 14a1 ⊗ χ₋₂₃ over K = ℚ(√−23) (computational report, with ramification-criterion companion)
  A computational and formally-verified study of the rank-2 arithmetic of the elliptic curve 14a1 twisted by the quadratic character χ₋₂₃ over the imaginary quadratic field K = ℚ(√−23) (discriminant −23, class number 3, analytic rank 2). Contents. (1) Main repor…
  datacite Burke III, Joesph Daniel 2026 置信度 0.66 Euler systemsIwasawa theoryelliptic curvesBirch–Swinnerton-Dyer conjecturep-adic L-functions
• The Hook Is Not the Boundary: Boundary Completeness in Pre-Execution Authorization
  Autonomous systems increasingly evaluate a proposed action before it executes. A callback fires, a policy is applied, a result is returned, and a record is written. This note argues that the arrangement establishes temporal interception and does not, on its ow…
  datacite Meyman, Edward 2026 置信度 0.66 runtime authorizationpre-execution authorizationboundary completenessauthorization boundaryauthorization artifact
• The Hook Is Not the Boundary: Boundary Completeness in Pre-Execution Authorization
  Autonomous systems increasingly evaluate a proposed action before it executes. A callback fires, a policy is applied, a result is returned, and a record is written. This note argues that the arrangement establishes temporal interception and does not, on its ow…
  datacite Meyman, Edward 2026 置信度 0.66 runtime authorizationpre-execution authorizationboundary completenessauthorization boundaryauthorization artifact
• The Neutral Boundary
  Autonomous agents are being composed into systems faster than anyone can account for what passes between them. The prevailing instinct is to make each agent more trustworthy: better models, better benchmarks, better guardrails. This paper argues that this inst…
  datacite Luciano, Michael 2026 置信度 0.66 AI agents; multi-agent systems; handoff validation; neutral boundary; reproducibility; AI governance.
• The Neutral Boundary
  Autonomous agents are being composed into systems faster than anyone can account for what passes between them. The prevailing instinct is to make each agent more trustworthy: better models, better benchmarks, better guardrails. This paper argues that this inst…
  datacite Luciano, Michael 2026 置信度 0.66 AI agents; multi-agent systems; handoff validation; neutral boundary; reproducibility; AI governance.
• Capability-Mediated Perimeters for Secure AI Agent Tool Execution: Formal Non-Escalation Guarantees and Empirical Evaluation Against Indirect Prompt Injection
  Version 10.0 (Enterprise Candidate v2 Release): Features the comprehensive 3,000-case common held-out evaluation across four disjoint pillars (1,800 attacks and 1,200 authentic operations), establishing an empirical +78.89 percentage point recall improvement o…
  datacite Das, Rudraneel 2026 置信度 0.66 Autonomous AI AgentsIndirect Prompt InjectionModel Context ProtocolCapability-Based Access ControlDIFC
• Capability-Mediated Perimeters for Secure AI Agent Tool Execution: Formal Non-Escalation Guarantees and Empirical Evaluation Against Indirect Prompt Injection
  Version 10.0 (Enterprise Candidate v2 Release): Features the comprehensive 3,000-case common held-out evaluation across four disjoint pillars (1,800 attacks and 1,200 authentic operations), establishing an empirical +78.89 percentage point recall improvement o…
  datacite Das, Rudraneel 2026 置信度 0.66 Autonomous AI AgentsIndirect Prompt InjectionModel Context ProtocolCapability-Based Access ControlDIFC
• Newer Is Not Truer: Three Presuppositions Behind the Recency Rule in Long-Term Agent Memory, and Why Retaining Both Records Relocates the Decision Rather Than Making It
  (c) 2026 Pranay Mahendrakar. Licensed under CC BY 4.0. An agent with persistent memory writes its own records, and two of them can disagree. Across the published systems examined here the resolution runs in one direction: the newer record supersedes the older.…
  datacite Mahendrakar, Pranay M. 2026 置信度 0.66 agent memoryknowledge conflictbelief revisionlong-term memoryLLM agents
• Newer Is Not Truer: Three Presuppositions Behind the Recency Rule in Long-Term Agent Memory, and Why Retaining Both Records Relocates the Decision Rather Than Making It
  (c) 2026 Pranay Mahendrakar. Licensed under CC BY 4.0. An agent with persistent memory writes its own records, and two of them can disagree. Across the published systems examined here the resolution runs in one direction: the newer record supersedes the older.…
  datacite Mahendrakar, Pranay M. 2026 置信度 0.66 agent memoryknowledge conflictbelief revisionlong-term memoryLLM agents
• Capability-Mediated Perimeters for Secure AI Agent Tool Execution: Formal Non-Escalation Guarantees and Empirical Evaluation Against Indirect Prompt Injection
  Version 9.0 (Rigorous Common-Set Benchmark & v2 Evolution): Introduces Mastyf Guard 1.5B v2 evaluated across an identical 3,000-case common held-out suite (1,800 attacks and 1,200 benign operations). Demonstrates a +78.89 percentage point recall improvement (1…
  datacite Das, Rudraneel 2026 置信度 0.66 Autonomous AI AgentsIndirect Prompt InjectionModel Context ProtocolCapability-Based Access ControlDIFC
• Aegis: A Bio-Inspired, Zero-Trust Architecture for Homeostatic AI Agent Governance
  Abstract: Current AI governance frameworks predominantly treat safety as an external perimeter, relying on prompt guardrails and post-hoc filters. While functional for static models, this paradigm fails when applied to Autonomous Agents capable of continuous r…
  datacite He, Muchen 2026 置信度 0.66 Autonomous Agents;Metabolic ConstraintsArtificial IntelligenceBio-Inspired AIAI Governance
• Aegis: A Bio-Inspired, Zero-Trust Architecture for Homeostatic AI Agent Governance
  Abstract: Current AI governance frameworks predominantly treat safety as an external perimeter, relying on prompt guardrails and post-hoc filters. While functional for static models, this paradigm fails when applied to Autonomous Agents capable of continuous r…
  datacite He, Muchen 2026 置信度 0.66 Autonomous Agents;Metabolic ConstraintsArtificial IntelligenceBio-Inspired AIAI Governance
• Aegis Cortex: A Bio-Inspired, Zero-Trust Architecture for Homeostatic AI Agent Governance
  Abstract: Current AI governance frameworks predominantly treat safety as an external perimeter, relying on prompt guardrails and post-hoc filters. While functional for static models, this paradigm fails when applied to Autonomous Agents capable of continuous r…
  datacite He, Muchen 2026 置信度 0.66 Autonomous Agents;Metabolic ConstraintsArtificial IntelligenceBio-Inspired AIAI Governance
• Clause AI-8: Entropy-Collapse Constraint — Mandatory Policy Diversity Floor for Autonomous AI Systems
  Formal derivation of MAI-1 Invariant 1, the Entropy-Collapse Constraint. This specification establishes a mathematically rigorous entropy floor for high-stakes AI systems, converting a training heuristic into an auditable deployment constraint. Financial marke…
  datacite Fields, Ryan 2026 置信度 0.66 entropy collapsepolicy diversityentropy floorstrategy collapsereinforcement learning
• Clause AI-8: Entropy-Collapse Constraint — Mandatory Policy Diversity Floor for Autonomous AI Systems
  Formal derivation of MAI-1 Invariant 1, the Entropy-Collapse Constraint. This specification establishes a mathematically rigorous entropy floor for high-stakes AI systems, converting a training heuristic into an auditable deployment constraint. Financial marke…
  datacite Fields, Ryan 2026 置信度 0.66 entropy collapsepolicy diversityentropy floorstrategy collapsereinforcement learning
• Capability-Mediated Perimeters for Secure AI Agent Tool Execution: Formal Non-Escalation Guarantees and Empirical Evaluation Against Indirect Prompt Injection
  Version 8.0 (Enterprise v2 Release & Open-Source Benchmark Suite): Evaluates Mastyf Guard across 50,000 primary instances and 3,658 open-source benchmark cases. Introduces Mastyf Guard 1.5B v2 with formal argument intent alignment (P(argument violates intended…
  datacite Das, Rudraneel 2026 置信度 0.66 Autonomous AI AgentsIndirect Prompt InjectionModel Context ProtocolCapability-Based Access ControlDIFC
• Adaptive Epistemological Regulation in Non-Stationary Environments: From Single-Agent Architecture to Decentralized Correction Protocol (AER-P)
  Classical models of intelligence, in both cognitive science and artificial intelligence architecture, implicitly equate increasing internal coherence with increasing intelligence. This paper introduces the Adaptive Epistemological Regulation framework (AER), w…
  datacite Imam, Petlje 2026 置信度 0.66 epistemological fragilityadaptive AIconcept driftmulti-agent systemsAER-P
• Adaptive Epistemological Regulation in Non-Stationary Environments: From Single-Agent Architecture to Decentralized Correction Protocol (AER-P)
  Classical models of intelligence, in both cognitive science and artificial intelligence architecture, implicitly equate increasing internal coherence with increasing intelligence. This paper introduces the Adaptive Epistemological Regulation framework (AER), w…
  datacite Imam, Petlje 2026 置信度 0.66 epistemological fragilityadaptive AIconcept driftmulti-agent systemsAER-P
• LATTICE: Governance-First Reference Pipeline
  LATTICE v2.0.0 — Reference engine for the revised Frontiers submission This release is the LATTICE governance engine accompanying the revised (second) submission of the manuscript "LATTICE: A Governance-First Architecture for Authorized Autonomous AI Operation…
  datacite Calboreanu, Elias 2026 置信度 0.66 AI governanceautonomous agentspolicy-as-codeformal methodscybersecurity
• LATTICE: Governance-First Reference Pipeline
  LATTICE v2.0.0 — Reference engine for the revised Frontiers submission This release is the LATTICE governance engine accompanying the revised (second) submission of the manuscript "LATTICE: A Governance-First Architecture for Authorized Autonomous AI Operation…
  datacite Calboreanu, Elias 2026 置信度 0.66 AI governanceautonomous agentspolicy-as-codeformal methodscybersecurity
• Profile → TVC → Canonical: A Three-Tier Knowledge Verification Architecture for Deterministic AI Reasoning – paper 2, version 1
  Abstract The realization of Artificial General Intelligence (AGI) requires not only novel architectural designs but also robust mechanisms for knowledge verification and management. While Large Language Models (LLMs) excel at pattern recognition, their probabi…
  datacite Brown, Cameron 2026 置信度 0.66 Artificial IntelligenceArtificial intelligenceArtificial Intelligence/economicsArtificial Intelligence/standardsArtificial Intelligence/trends
• Profile → TVC → Canonical: A Three-Tier Knowledge Verification Architecture for Deterministic AI Reasoning – paper 2, version 1
  Abstract The realization of Artificial General Intelligence (AGI) requires not only novel architectural designs but also robust mechanisms for knowledge verification and management. While Large Language Models (LLMs) excel at pattern recognition, their probabi…
  datacite Brown, Cameron 2026 置信度 0.66 Artificial IntelligenceArtificial intelligenceArtificial Intelligence/economicsArtificial Intelligence/standardsArtificial Intelligence/trends
• EFWAG 2.0 : Game-Theoretical Extension of the EFWAG Law via Nash Equilibrium
  Author’s Note (August 2026) This record is retained as an AI-assisted exploratory attempt to relate the EFWAG framework to game theory and Nash equilibrium. Its mathematical definitions, derivations, and equilibrium claims have not been independently reviewed …
  datacite Shin, Hyun-Seop 2025 置信度 0.66 EFWAG, Nash Equilibrium, Game Theory, AI Alignment, Utility Function, Agent-Based Modeling, Machine Behavior, Cognitive Science, AI-assisted Epistemology, Structural Law
• Planetary-Embedded Multi-Agent Systems (PEMAS): A Synthetic Experimental Framework for Planetary-Aware AI Governance
  Overview This release contains the first stable research artifact for Planetary-Embedded Multi-Agent Systems (PEMAS), an exploratory computational framework investigating whether ecological and planetary conditions can function as endogenous governance signals…
  datacite Palis, Sabrina 2026 置信度 0.66
• Planetary-Embedded Multi-Agent Systems (PEMAS): A Synthetic Experimental Framework for Planetary-Aware AI Governance
  Overview This release contains the first stable research artifact for Planetary-Embedded Multi-Agent Systems (PEMAS), an exploratory computational framework investigating whether ecological and planetary conditions can function as endogenous governance signals…
  datacite Palis, Sabrina 2026 置信度 0.66
• verifiable-gates — a rule catalogue where every rule carries the incident that produced it
  A catalogue of production-discipline rules for software projects, extracted from a reference implementation where each one was learned from a real failure. Every rule records the incident behind it, so a reader can judge whether the conditions that produced it…
  datacite Sriphua, Sayam 2026 置信度 0.66 software governanceAI-assisted developmentcontinuous integrationsecure software developmentdeveloper experience
• verifiable-gates — a rule catalogue where every rule carries the incident that produced it
  A catalogue of production-discipline rules for software projects, extracted from a reference implementation where each one was learned from a real failure. Every rule records the incident behind it, so a reader can judge whether the conditions that produced it…
  datacite Sriphua, Sayam 2026 置信度 0.66 software governanceAI-assisted developmentcontinuous integrationsecure software developmentdeveloper experience
• Multi-Agent AI Desktop Tool for Molecular Docking Using AutoDock Vina
  An open-source desktop GUI wrapping a multi-agent pipeline for molecular docking using AutoDock Vina. Accepts a compound name (PubChem) and one or more receptor PDB IDs (RCSB), then runs the full end-to-end workflow: ligand preparation with RDKit and Meeko, re…
  datacite Shetty, Manu Kumar 2026 置信度 0.66 molecular-dockingautodock-vinapharmacology-educationstructure-based-drug-designmedical-education
• Multi-Agent AI Desktop Tool for Molecular Docking Using AutoDock Vina
  An open-source desktop GUI wrapping a multi-agent pipeline for molecular docking using AutoDock Vina. Accepts a compound name (PubChem) and one or more receptor PDB IDs (RCSB), then runs the full end-to-end workflow: ligand preparation with RDKit and Meeko, re…
  datacite Shetty, Manu Kumar 2026 置信度 0.66 molecular-dockingautodock-vinapharmacology-educationstructure-based-drug-designmedical-education
• Containment as a System Property: Assurance Obligations for Frontier Cyber-Capability Evaluations after the OpenAI–Hugging Face Incident
  Independent security research note examining containment assurance after the July 2026 OpenAI–Hugging Face incident. Drawing on the public incident records from OpenAI, Hugging Face, and METR/Redwood Research together with established systems-security, AI-cont…
  datacite Smith, Jeff 2026 置信度 0.66 AI securityautonomous agentscyber-capability evaluationagent containmentsandboxing
• Containment as a System Property: Assurance Obligations for Frontier Cyber-Capability Evaluations after the OpenAI–Hugging Face Incident
  Independent security research note examining containment assurance after the July 2026 OpenAI–Hugging Face incident. Drawing on the public incident records from OpenAI, Hugging Face, and METR/Redwood Research together with established systems-security, AI-cont…
  datacite Smith, Jeff 2026 置信度 0.66 AI securityautonomous agentscyber-capability evaluationagent containmentsandboxing
• OzgurEren80/ASVR_1.0: Acting in Social VR for Immersive Learning 1.0
  ASVR_1.0 This is the initial prototype for a social VR project implemented in Unity and Engage SDK. The project should be uploaded to a valid Engage XR account via the location manager in Unity. After the upload is complete it can be run as a session in Engage…
  datacite OzgurEren80 2026 置信度 0.66
• Capability-Mediated Perimeters for Secure AI Agent Tool Execution: Formal Non-Escalation Guarantees and Empirical Evaluation Against Indirect Prompt Injection
  Version 7 (Definitive Multi-Suite Architecture Edition): Visually integrates Tier 2.5 DIFC into Figures 2 and 3. Expands isolated exfiltration evaluation to 1,152 multi-suite cases (InjecAgent DS Base/Enhanced, BIPIA, Garak) with automated schema-based label a…
  datacite Das, Rudraneel 2026 置信度 0.66 Autonomous AI AgentsIndirect Prompt InjectionModel Context ProtocolCapability-Based Access ControlDIFC
• Capability-Mediated Perimeters for Secure AI Agent Tool Execution: Formal Non-Escalation Guarantees and Empirical Evaluation Against Indirect Prompt Injection
  Version 6 (Definitive Peer-Review Edition): Integrates formal Theorem 2 (Taint-Constrained Egress Specification) with automated label assignment and legitimate workflow declassification analysis. Reconciles macro 50,000-instance evaluation (99.33% recall, 9.26…
  datacite Das, Rudraneel 2026 置信度 0.66 Autonomous AI AgentsIndirect Prompt InjectionModel Context ProtocolCapability-Based Access ControlDIFC
• Capability-Mediated Perimeters for Secure AI Agent Tool Execution: Formal Non-Escalation Guarantees and Empirical Evaluation Against Indirect Prompt Injection
  Version 5 (Canonical Reconciled Edition): Establishes complete mathematical consistency across the 50,000-instance macro evaluation (99.33% recall, 9.26% FPR, 0.005 ms amortized latency). Formalizes Theorem 2 (Taint-Constrained Egress) and Decentralized Inform…
  datacite Das, Rudraneel 2026 置信度 0.66 Autonomous AI AgentsIndirect Prompt InjectionModel Context ProtocolCapability-Based Access ControlDIFC
• Learning Among Learners: A Narrative Review of Multi-Agent Reinforcement Learning from Markov Games to Deep Emergent Play
  Multi-agent reinforcement learning---the learning of behavior when the environment's other agents learn too---moved from Tan's independent learners and Littman's Markov games framework through the cooperative dynamics' analyses and the surveys' question to the…
  datacite Revista, Zen, IA, 10 2026 置信度 0.66 multi-agent reinforcement learningMarkov gamesnon-stationaritycooperative MARLQMIX
• Learning Among Learners: A Narrative Review of Multi-Agent Reinforcement Learning from Markov Games to Deep Emergent Play
  Multi-agent reinforcement learning---the learning of behavior when the environment's other agents learn too---moved from Tan's independent learners and Littman's Markov games framework through the cooperative dynamics' analyses and the surveys' question to the…
  datacite Revista, Zen, IA, 10 2026 置信度 0.66 multi-agent reinforcement learningMarkov gamesnon-stationaritycooperative MARLQMIX
• Capability-Mediated Perimeters for Secure AI Agent Tool Execution: Formal Non-Escalation Guarantees and Empirical Evaluation Against Indirect Prompt Injection
  Version 4 (Canonical Empirical Update with DIFC): Evaluates Mastyf Guard across 50,000 empirical instances. Introduces Decentralized Information Flow Control (DIFC) and dynamic session taint tracking (Tier 2.5), achieving 100.00% defense on InjecAgent Data Ste…
  datacite Das, Rudraneel 2026 置信度 0.66 Autonomous AI AgentsIndirect Prompt InjectionModel Context ProtocolCapability-Based Access ControlDIFC
• Impact of etanercept on the progression of undifferentiated arthritis to rheumatoid arthritis: A prospective observational study in China.
  This study explores the association between tumor necrosis factor (TNF) antagonist therapy and the progression from undifferentiated arthritis (UA) to rheumatoid arthritis (RA). This single-center prospective observational real-world study enrolled 70 patients…
  pubmed Shen J, Li L, Li X, Leng L 等 2026 Aug 14 置信度 0.82
• Synergistic lethality of combination treatment with Trop2-directed antibody-drug conjugate sacituzumab govitecan and TRAIL agonists in triple negative breast cancer.
  Sacituzumab govitecan (SG) is an antibody drug conjugate targeting trophoblast cell surface antigen 2 (Trop2) that is approved for treatment of patients with metastatic triple negative breast cancer (TNBC). Tumor necrosis factor-related apoptosis inducing liga…
  pubmed Addissie YA, Greer YE, Nair J, Lipkowitz S 2026 Aug 14 置信度 0.82
• Inhibition and Molecular Recognition of Lactoperoxidase by Acetohydrazide-Based Sulfonamide Derivatives.
  Lactoperoxidase (LPO) is a heme-containing enzyme widely distributed in mammalian secretions, contributing to host defense through the generation of antimicrobial oxidants. Unintended inhibition of LPO by therapeutic agents may impair mucosal immunity, making …
  pubmed Gökçe B, Arslan G, Muhammed MT, Albayrak Ö 2026 Sep 置信度 0.82
• Novel triglyceride-lowering therapies to reduce the risk of acute pancreatitis in hypertriglyceridaemia: a protocol for systematic review and meta-analysis.
  Hypertriglyceridaemia is a major risk factor and rising aetiology for acute pancreatitis (AP), a condition associated with significant morbidity and mortality. Novel triglyceride-lowering therapies targeting key regulators of lipoprotein metabolism, specifical…
  pubmed Wu Y, Liu S, Luo W, Rao J 等 2026 Aug 14 置信度 0.82
• A universal cell-based method for high-throughput analysis of viroporin function and inhibition.
  Viroporins are transmembrane proteins encoded mainly by RNA viruses that oligomerize to form pores essential for multiple stages of the viral life cycle. Although they represent attractive antiviral drug targets, progress has been limited in part by the absenc…
  pubmed Kjær VMS, Faas F, Bentzen BH, Rosenkilde MM 2026 Sep 置信度 0.82
• Model Gateway: Management platform for model-driven drug discovery.
  Pharmaceutical drug discovery demands machine learning (ML) infrastructure that goes beyond general-purpose Machine Learning Operations: inference-time composition of multiple models for multiparameter optimization, version management for physics-based models …
  pubmed Wu YS, Vaddadi SM, Rollins ZA, Morin NA 2026 置信度 0.82
• Reprogramming HER2-Positive gastroesophageal cancer immune contexture with bispecific therapy: HERIZON-GEA-01.
  The HERIZON-GEA-01 trial in patients with advanced HER2-positive gastroesophageal adenocarcinoma demonstrated improved outcomes with the addition of the HER2xHER2-bispecific antibody zanidatamab to chemotherapy. The addition of tislelizumab, an anti-PD-1 antib…
  pubmed Sundar R, Klempner SJ 2026 Aug 14 置信度 0.82
• Perceived coping and healing among Chinese emerging-adult users: The shaping role of AI emotional companion agents.
  AI emotional companion agents are increasingly used for everyday emotional support, yet evidence remains limited regarding how observable service cues are translated into proximal, nonclinical support value during an initial encounter. Drawing on a stimulus-or…
  pubmed Zhang W, Xie G 2026 Sep 置信度 0.82
• The AI Colleague: Reimagining Interprofessional Collaboration and Education in Medicine.
  AI is no longer confined to optional decision support; it is becoming a routine presence in clinical workflows, shaping diagnostic hypotheses, triage priorities, risk estimates, and documentation. Yet most educational responses still treat AI as a tool operate…
  pubmed Yuh C, Cho CH, Lee YM 2026 Aug 14 置信度 0.82
• Symbiotic Alignment via Collective Predictive Coding: A Theoretical Framework for Co-Creative Human-AI Ecosystems.
  The rapid integration of artificial intelligence (AI) into society has surfaced systemic risks, particularly deep polarization exacerbated by algorithms optimizing for individual engagement. The dominant alignment paradigm, reliant on unilateral control (e.g.,…
  pubmed Taniguchi T, Hayashi Y, Hirose M, Oka M 等 2026 Aug 12 置信度 0.82
• Encoded metabolic remodeling amplifies drug resistance in Mycobacterium tuberculosis.
  Antibiotic pressure causes pathogens to evolve many forms of altered drug susceptibility. In addition to target or activator mutations conferring canonical drug resistance, mutations can serve as steppingstones to or enhancers of resistance. In clinical strain…
  pubmed Frey AM, Babunovic GH, Culviner PH, Wang X 等 2026 Aug 置信度 0.82
• PCK2 Inhibition Reverses Cisplatin Resistance of Non-Small Cell Lung Cancer by Triggering Ferroptosis.
  Non-small cell lung cancer (NSCLC) accounts for ~85% of lung cancers, with platinum-based chemotherapy as the main treatment. Ferroptosis has been implicated in cancer chemoresistance, yet the molecular mechanisms linking metabolic reprogramming to ferroptosis…
  pubmed Liu J, Wang Z, Gu C, Chen Y 等 2026 Aug 31 置信度 0.82
• Hyperbaric oxygen treatment and toll-like receptor 5 in radioprotection of epithelial cells.
  Irradiation of tumours in the pelvic area may lead to adverse effects such as vaginal fibrosis and dyspareunia. We investigated the radioprotective effects of hyperbaric oxygen (HBOT) and toll-like receptor 5 (TLR5) in epithelial cells.
  pubmed Sallam L, Rychlíková L, Mölne J, Bergo MO 等 2026 置信度 0.82
• Heat Shock Protein Inhibitor Tanespimycin (17AAG) Suppresses SARS-CoV-2 Main Protease Activity and Is More Potent Than Clinically Approved Antiviral Nirmatrelvir.
  The COVID-19 pandemic caused by SARS-CoV-2 created a global health crisis, and the virus still circulates, mutates, and causes illness and death. Vaccination remains the primary defense, but effectiveness can be reduced in immunocompromised individuals and aga…
  pubmed Mukherjee G, Chakraborty S, Chandra A, Chowdhury G 等 2026 Aug 14 置信度 0.82
• Phytochemical Profiling, Biological Evaluation, and Molecular Insights Into the Urease Inhibitory Potential of Fraxinus angustifolia Crude Extract and Fractions.
  Fraxinus angustifolia Vahl. has long been used in traditional medicine for the management of inflammatory and gastrointestinal disorders. This study investigated the anti-urease, anti-Helicobacter pylori, and anti-inflammatory activities of the ethanolic leaf …
  pubmed Belkhir S, Rahmani-Berboucha M, Zemam SS, Debbache-Benaida N 等 2026 Aug 置信度 0.82
• The LKB1-AMPK pathway in NAFLD: molecular mechanisms and therapeutic implications.
  The LKB1-AMPK signaling pathway is a central regulator of hepatic energy homeostasis and is increasingly implicated in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). LKB1-mediated AMPK activation promotes fatty acid β-oxidation, autophagy…
  pubmed Goleij P, Tabari MAK, Naser Y, Alataa R 等 2026 Aug 14 置信度 0.82
• Targeting WEE1 kinase: an integrated machine learning-cheminformatics framework for ultra-large-scale virtual screening and novel inhibitor discovery.
  WEE1 kinase, a critical regulator of the G2/M checkpoint, represents a validated therapeutic target in tumors harboring defects in DNA damage response (DDR) pathways. Although clinical inhibitors such as adavosertib have demonstrated therapeutic potential, cha…
  pubmed Muthuraj R, Pacharla M, Kumar NA, Gopal D 等 2026 Aug 14 置信度 0.82
• Biochemical and cellular effects of propolis and silver nanoparticle combination: apoptotic signaling and antibiofilm activity.
  Cancer and antimicrobial resistance represent two of the most critical challenges to global health. The limitations of conventional therapies, including severe side effects, drug resistance, and high failure rates, necessitate the exploration of novel and syne…
  pubmed Erdoğan E, Özdem B, Çimentepe ÖÖ, Tekedereli I 等 2026 Aug 14 置信度 0.82
• Discovery of Polycyclic Polyprenylated Acylphloroglucinols from Hypericum androsaemum as Dual-Mechanism Inhibitors of Mycobacterium tuberculosis GlmU Acetyltransferase.
  (±)-Hypericandrone A (HCA, 1), an unprecedented pair of enantiomeric polycyclic polyprenylated acylphloroglucinols (PPAPs), and its biosynthetic congener hypericandrone B (HCB, 2) were isolated from the fruits of Hypericum androsaemum. Compound 1 features…
  pubmed Wei J, Jin X, Zhao X, Fan P 等 2026 Aug 14 置信度 0.82
• Activity of Thiourea-Linked Diamidines against Multidrug-Resistant Staphylococcus aureus.
  Staphylococcus aureus is a leading cause of antibiotic-resistant infections worldwide. Therefore, there is a constant need to develop new growth inhibitors. Pentamidine analogs (PAs) composed of thiourea-linked amidines were evaluated for activity against meth…
  pubmed Jin Y, Story S, Chamberlin J, Arya DP 2026 Aug 14 置信度 0.82
• Inhibitors of the Influenza Virus Polymerase Basic 2 (PB2): Recent Advances and Future Perspectives.
  Influenza, an acute respiratory infectious disease caused by influenza viruses, poses a serious public health threat with high infectivity and virulence. Existing antivirals suffer from numerous limitations, such as the frequent emergence of drug resistance an…
  pubmed Zhang X, Jia H, Wang X, Ju H 等 2026 Aug 14 置信度 0.82
• Deadbolt Drug Discovery: Locking the Door to Class 1 Viral Entry by Small Molecules.
  The continued emergence of viral pathogens underscores the need for novel antiviral therapeutics with improved efficacy. Small-molecule inhibitors of viral entry are attractive antiviral agents because they block the virus at its earliest step, preventing the …
  pubmed Sloan JP, Rong L, Moore TW 2026 Aug 14 置信度 0.82
• Green Synthesis, In Silico Molecular Docking, and Evaluation of Pyrazole Derivatives for Their Antifungal and Antinemic Activity.
  A series of 25 pyrazole derivatives was synthesized via ultrasonication-assisted cyclization of chalcones with phenylhydrazine and characterized using 1 H NMR, 1 3 C NMR, and LC-HRMS. Biological evaluation revealed that P-25 [5-(4-fluorophenyl)-1,3-diphenyl-1H…
  pubmed Kumar R, Tripathi K, Kaushik P, Kumar V 等 2026 Aug 置信度 0.82
• Deep learning-based automated identification of papillary bladder cancer from endoscopic still images using SE-ResNeXt-50.
  Bladder cancer remains a major global health challenge, necessitating rigorous endoscopic surveillance and the precise identification of neoplastic lesions. While the detection of overt tumors is routine, achieving high specificity and distinguishing borderlin…
  pubmed Matsushita Y, Tamura A, Masuda T, Hasegawa O 等 2026 Aug 14 置信度 0.82
• Focused Update to International Consensus Recommendations for the Use of Prolonged-Infusion Beta-Lactam Antibiotics Among Severely Ill Adult Patients: Endorsed by the American College of Clinical Pharmacy, British Society for Antimicrobial Chemotherapy, Cystic Fibrosis Foundation, European Society of Clinical Microbiology and Infectious Diseases, Infectious Diseases Society of America, Society of Critical Care Medicine, and Society of Infectious Diseases Pharmacists.
  In 2023, international consensus recommendations suggested the use of prolonged-infusion beta-lactam antibiotics over short-infusion dosing in severely ill adult patients to improve mortality or clinical cure, although the certainty of evidence was very low. W…
  pubmed Hong LT, FakhriRavari A, Ulldemolins M, Roberts JA 等 2026 Sep 置信度 0.82
• Targeting the unfolded protein response in cancer: mechanisms, small-molecule inhibitors, and translational challenges.
  Endoplasmic reticulum (ER) stress, triggered by the accumulation of misfolded proteins, activates the unfolded protein response (UPR) to restore protein homeostasis. Dysregulated ER stress responses have emerged as critical modulators of cancer progression and…
  pubmed Lin M, Li Z 2026 置信度 0.82
• A Locally Executed Agentic Artificial Intelligence Framework for Deduplication, Screening, and Structured Data Extraction in Spine Surgery Systematic Reviews: A PRISMA-Transparent Reporting of Artificial Intelligence in Comprehensive Evidence Synthesis-Compliant Evaluation.
  Systematic reviews and meta-analyses remain time-consuming and labor-intensive. We developed and validated a locally executed agentic artificial intelligence (AI) framework for deduplication, screening, and structured data extraction in systematic reviews, rep…
  pubmed Muthu S, Kolarpatti Ponnusamy DV, Viswanathan VK, Rajappan Chandra SK 等 2026 Jul-Sep 置信度 0.82
• Multiagent Data Mining for Enhanced Machine Learning Prediction of Delayed Fluorescence Materials.
  One of the primary bottlenecks hindering the widespread adoption of AI-driven exploration of novel materials in the field of organic light-emitting diodes (OLEDs) is the labor-intensive process of constructing high-quality data sets required for training accur…
  pubmed He Z, Zhang H, Wang Y, Yang W 等 2026 Aug 11 置信度 0.82
• AI Agents and the Future of Clinical Judgment in Medical Education: Opportunities, Challenges, and the Need for Human-Centered Integration.
  Artificial intelligence (AI) is actively transforming health professions education by introducing innovative methodologies for learning, simulation, and clinical decision support. The recent emergence of autonomous AI agents-equipped with advanced capabilities…
  pubmed Ahmady S, Kohan N, Monajemi A 2026 Aug 置信度 0.82
• Rational design and biological validation of EZH2/PD-L1 bifunctional inhibitors for colorectal cancer immunotherapy.
  This study aims to identify novel small-molecule inhibitors that target both PD-L1 and EZH2 to enhance colorectal cancer immunotherapy.
  pubmed Guan B, Cheng B, Li H 2026 置信度 0.82
• The pivotal role of SCD1 in digestive cancers: Bridging lipid metabolic reprogramming and programmed cell death (Review).
  Stearoyl‑CoA desaturase‑1 (SCD1) has emerged as a critical nexus linking lipid metabolic reprogramming to the regulation of cell death. Frequently overexpressed in digestive system malignancies ‑ including gastric, liver and colorectal can…
  pubmed Fu Y, Wang Z, Liu L, Tang X 2026 Oct 置信度 0.82
• Boronic Acid Inhibitors of β-Lactamases: A Promising Strategy Against Antimicrobial Resistance.
  The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β-lactamases, a class of enzymes responsible for the inactivation of β-lactam antibiotics. Among the most promising strategies t…
  pubmed Santi N, Corsini F, Bonomo RA, Caselli E 等 2026 Aug 14 置信度 0.82
• Recombinant Artemin-Fc Fusion Protein Attenuates TLR4/NF-κB-Associated Neuroinflammation and Modulates Inhibitory/Excitatory Synaptic Marker Expression After Spinal Cord Injury.
  Spinal cord injury (SCI) can cause severe neurological dysfunction and the occurrence of chronic neuropathic pain, which can manifest as the occurrence of abnormal pain and hyperalgesia. Artemin (ARTN) is a member of the glial cell-derived neurotrophic factor …
  pubmed Lu W, Tu Y, Wang R, Jiang M 等 2026 Aug 置信度 0.82
• Deep reinforcement learning-based lens design.
  Lens design is an important and time-consuming process that requires expert knowledge and multiple iterations of parameter adjustment and optimization to meet the required optical performance. While artificial intelligence (AI)-based approaches using expert sy…
  pubmed Ping Yow A, Zhang Y, Nobis T, Wong D 等 2026 置信度 0.82
• Active ingredients and molecular targets of Tripterygium wilfordii against colorectal cancer: network pharmacology, molecular docking, molecular dynamics simulations and in vitro evaluation.
  Colorectal cancer (CRC) is one of the common malignant tumors of the gastrointestinal tract, encompassing both colon cancer and rectal cancer. This study explores the therapeutic potential of T. wilfordii in CRC through network pharmacology, molecular docking,…
  pubmed Gu Q, Zhao S, Zhang X, Zhou L 等 2026 Aug 13 置信度 0.82
• Beyond current standards: combination therapy and emerging targets in diabetic kidney disease.
  Diabetic kidney disease continues to be a major contributor to kidney failure and is strongly associated with adverse cardiovascular outcomes. Even with routine use of renin-angiotensin system blockade, many patients show ongoing disease progression, indicatin…
  pubmed Lee J, Yu MY, Korean Diabetic Kidney Disease Study Group 2026 Aug 13 置信度 0.82
• Evaluation of an AI-powered tool in improving lesion visualization on standard-dose contrast-enhanced brain MRI: a retrospective, multicenter study.
  Artificial intelligence (AI) algorithms have been used to synthesize standard-dose images from low-dose images in brain MRI, but have less been evaluated to boost standard-dose contrast to approximate higher-dose effect. This study aims to evaluate the perform…
  pubmed Gao Y, Chen B, Wen C, Chen G 等 2026 Aug 13 置信度 0.82
• Beyond the ATP-binding pocket: emerging strategies in kinase targeting from allosteric inhibition to targeted protein degradation.
  Protein kinases are central regulators of cellular signaling and remain a major target class in precision medicine. While ATP-competitive inhibitors-including conformation-selective and covalent agents-have delivered substantial clinical benefit, durable respo…
  pubmed Zhou M, Li L, Tang X, Zhao Y 等 2026 Aug 13 置信度 0.82
• Using Intralesional Adalimumab for Chronic Refractory Cutaneous Granulomatous Inflammation.
  Chronic localized granulomatous dermatoses present a therapeutic challenge, particularly in cosmetically sensitive areas where standard treatments often prove insufficient or intolerable. We describe a technique using intralesional injection of adalimumab to t…
  pubmed Nukaly HY, Srikakolapu S, Elston DM 2026 Jun 置信度 0.82
• AI-driven dual-task prediction model for co-stratifying efficacy and toxicity in NSCLC immunotherapy.
  While effective against non-small cell lung cancer (NSCLC), PD-1 inhibitors can induce immune-related adverse events (irAEs), occurring in up to 15.2% of patients and potentially fatal. Currently, effective predictive biomarkers capable of simultaneously forec…
  pubmed Ding H, Ren Y, Ding S, Chen Y 等 2026 Aug 置信度 0.82
• Discovery, Synthesis, and Biological Evaluation of 1,3,4,5-Tetrahydro-6H-pyrano[4,3-c]isoquinolin-6-one Derivatives as Novel and Highly Selective PARP1 Inhibitors.
  Developing highly selective PARP1 inhibitors is a promising strategy to improve the therapeutic window compared with dual PARP1/2 inhibitors. Through structure-guided design and optimization, we developed (R)-A17, a novel, highly selective PARP1 inhibitor feat…
  pubmed Guo Z, Sun R, Yang L, Zou Y 等 2026 Aug 13 置信度 0.82
• Discovery and Optimization of Novel Nonhydroxamate LpxC Inhibitors for the Treatment of Multidrug-Resistant Gram-Negative Infections.
  This report summarizes the discovery and optimization of a novel series of nonhydroxamate inhibitors targeting LpxC, a Zn2+-dependent hydrolase that is essential for the survival of Gram-negative bacteria. Beginning with a 5-hydroxypyrimidin-4-one metal-bindin…
  pubmed Martin DP, Teng M, Nammalwar B, Perez C 等 2026 Aug 13 置信度 0.82
• Discovery and Optimization of a WRN Helicase Inhibitor Series through Structure-Guided Drug Design from a Covalent Fragment Binding Insight.
  WRN helicase activity inhibition has emerged as a promising therapeutic approach for targeting cancer cells with specific DNA repair deficiencies, especially those with microsatellite instability (MSI). Herein, we report a novel covalent WRN helicase inhibitor…
  pubmed Toure M, Yan XC, Bai Y, Sosa-Alvarado BA 等 2026 Aug 13 置信度 0.82
• Recent Advances in Antiviral Medicinal Chemistry against Flaviviruses Driven by Multistrategic Approaches.
  Flaviviruses constitute a global health threat, mainly because of the increasing geographical spread of vectors and the suboptimal efficacy of existing prophylactic vaccines. Despite the substantial clinical burden imposed by these pathogens, a critical gap re…
  pubmed Hu X, Hu T, Loregian A, Yang H 等 2026 Aug 13 置信度 0.82
• Discovery of the First Highly Potent and Selective Peptide Inhibitor Targeting Microtubule-MAP7 Interaction via Structure-Based Design for Suppressing Colorectal Cancer Cell Proliferation.
  Microtubules are core cytoskeletal components for cellular activities. Their interaction with microtubule-associated protein 7 (MAP7) is crucial for cell proliferation, cellular component transport, and morphological regulation. The conserved microtubule surfa…
  pubmed Niu MM, Wang Y, Wu H, Chen S 等 2026 Aug 13 置信度 0.82
• Structure-Based Discovery of JN210 as a Potent Dual DCN1/HDAC Inhibitor for the Treatment of Nonsmall Cell Lung Cancer.
  Resistance to monotherapy remains a major challenge in the treatment of nonsmall cell lung cancer (NSCLC), highlighting the need for innovative therapeutic strategies. To address this issue, we developed a dual-targeting strategy aimed at simultaneously inhibi…
  pubmed Zheng T, Li Y, Huang Y, He L 等 2026 Aug 13 置信度 0.82
• Discovery of Potent and Orally Bioavailable Diaminoquinazoline-Derived mRNA Decapping Scavenger (DcpS) Enzyme Inhibitors for Treatment of Solid Tumors.
  Decapping Scavenger (DcpS) enzyme, a pyrophosphatase involved in mRNA regulation via mRNA cap degradation, has been identified as a promising oncology target in fragile histidine triad (FHIT) deficient cancers such as AML and GBM but remains underexplored in b…
  pubmed Scholz SO, Dudnik AS, Vasilopoulos A, Jia ZJ 等 2026 Aug 13 置信度 0.82
• Discovery and Preclinical Characterization of I-0436650, a Selective SHP2 Allosteric Inhibitor for RAS-Driven Cancers.
  SHP2 (Src homology 2 (SH2)-containing protein tyrosine phosphatase 2) is a tyrosine phosphatase that plays a critical role in numerous physiological and pathological cellular processes, including cell proliferation, survival, and migration through the regulati…
  pubmed Ciammaichella A, Puca F, Fabbrini D, Randazzo P 等 2026 Aug 13 置信度 0.82
• Discovery of Deuterated 3,4-Dihydro-benzo[e][1,4]diazepine-2,5-dione Derivatives as Potent, Selective and Orally Bioavailable ROCK2 Inhibitors.
  Rho-associated coiled-coil-containing kinase 2 (ROCK2) is a key regulator of cellular motility and invasion and represents a promising therapeutic target for metastatic breast cancer. Through systematic structure-activity relationship (SAR) studies, we designe…
  pubmed Li Y, Zhang L, Xu H, Huang Y 等 2026 Aug 13 置信度 0.82
• Discovery of Reversible Lysine-Specific Demethylase 1 Inhibitors with Pyrazole Core for Small Cell Lung Cancer Treatment.
  Selective lysine-specific demethylase 1 (LSD1) inhibition has emerged as a robust strategy for small cell lung cancer (SCLC) eradication. Herein, we describe the structural design, synthesis, and biological evaluation of novel reversible LSD1 inhibitors contai…
  pubmed Choi J, Kim J, Lee S, Kim J 等 2026 Aug 13 置信度 0.82
• Discovery of a Potent, Selective, and Orally Bioavailable Achiral MAT2A Inhibitor for Treating MTAP-Deficient Cancers.
  Targeting methionine adenosyltransferase 2A (MAT2A) represents an attractive synthetic lethal approach for treating methylthioadenosine phosphorylase (MTAP)-deleted cancers. Despite promising progress in the development of MAT2A inhibitors, many reported compo…
  pubmed Lin L, Xie Z, Liu J, Fan Z 等 2026 Aug 13 置信度 0.82
• Property-Biased Covalent DNA-Encoded Library Screening Enabled the Discovery of AM-8719, A Structurally Novel, CNS-Penetrant KRAS G12C Inhibitor.
  Activating mutations in the Kirsten rat sarcoma (KRAS) gene are prevalent oncogenic drivers in nonsmall cell lung cancer (NSCLC). Patients harboring KRAS-mutant lung cancers frequently develop central nervous system (CNS) metastases. Although approved KRAS G12…
  pubmed Rast S, Morgan-Fisher M, Blomquist SD, Cadahía JP 等 2026 Aug 13 置信度 0.82
• Targeting Telomerase Cajal Body Protein 1 (TCAB1) as a Novel Strategy for Discovering Potent Telomerase Inhibitors That Enhance Antitumor Immunity.
  Telomerase, responsible for extending telomeres and maintaining the malignant potential of tumors, has long been deemed a promising anticancer target. Nonetheless, because of its complex composition, the discovery of highly efficient telomerase inhibitors is a…
  pubmed Zuo H, Gao X, Wang Y, Yan Y 等 2026 Aug 13 置信度 0.82
• Structure-Based Drug Design of Novel Indazole/Indolinone-Based Biaryl Derivatives as Oral IRAK4 Inhibitors for the Treatment of Inflammatory Diseases.
  Pathological inflammation in multiple diseases arises from dysregulated innate immune signaling, wherein the interleukin-1 receptor-associated kinase 4 (IRAK4) acts as a critical node that mediates pro-inflammatory cascades and cytokine release downstream of t…
  pubmed Zhang Z, Wang X, Luo X, Li C 等 2026 Aug 13 置信度 0.82
• Overcoming hERG Cardiotoxicity in Psammaplysene D via Rational Design to Discover a Safe Antifibrotic Lead.
  Liver fibrosis is a major global health challenge with limited treatment options. The marine natural product Psammaplysene D (PD) exhibits promising antifibrotic activity but suffers from significant hERG channel inhibition (>99% at 5 μM) and moderate…
  pubmed Yang T, Li R, Li R, Zhang X 等 2026 Aug 13 置信度 0.82
• Selective Brain-Penetrant TTBK1 Inhibitors Modulate TDP-43 Pathology and Rescue Cognitive Deficits in a Mouse Model of TDP-43 Proteinopathy.
  Transactive response DNA-binding protein of 43 kDa (TDP-43) is a pathological hallmark of neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Modulation of TDP-43 pathology represents a promising diseas…
  pubmed Sanchez-Santos C, Jimenez-Amor A, Martinez-Gonzalez L, Nozal V 等 2026 Aug 13 置信度 0.82
• Discovery of a Novel HSP90-Targeting Inhibitor for AML from the Marine Aaptamine Scaffold.
  Resistance to single-target therapies has spurred interest in multitarget strategies for acute myeloid leukemia (AML). Heat shock protein 90 (HSP90), a chaperone that stabilizes numerous oncogenic client proteins, represents an attractive therapeutic target fo…
  pubmed Xue H, Zhu H, Liu S, Qian Y 等 2026 Aug 13 置信度 0.82
• Discovery of Thiazolo[5,4-c]pyridine Derivatives as Novel Hematopoietic Progenitor Kinase 1 Inhibitors for Tumor Immunotherapy.
  Hematopoietic progenitor kinase 1 (HPK1) functions as an intracellular negative regulator of T-cell receptor signaling, and its inhibition has emerged as a promising strategy to counteract T-cell exhaustion and potentiate antitumor immunity. Through rational s…
  pubmed Wang Y, Yang Y, Yu Y, Liu B 等 2026 Aug 13 置信度 0.82
• Structure-Activity Relationship Study of Anti-Cryptosporidium Benzoxaboroles Yields Enhanced Potency and Curative Efficacy.
  Cryptosporidiosis is a major cause of life-threatening diarrhea in children and chronic diarrhea in immunocompromised individuals. Our previous work identified pyrazolo[3,4-d]pyrimidine benzoxaborole (2) as an orally efficacious inhibitor of Cryptosporidium wi…
  pubmed Guin S, Teixeira JE, Miller P, Sarkar A 等 2026 Aug 13 置信度 0.82
• Discovery of ZJC-11 as a Novel Selective CDK7 Inhibitor for Treating Triple-Negative Breast Cancer by Inducing Cell Senescence.
  The development of cyclin-dependent kinase 7 (CDK7) inhibitors represents a promising therapeutic strategy for triple-negative breast cancer (TNBC). Herein, we designed and synthesized 21 novel CDK7-targeted small molecules and identified ZJC-11 as a potent le…
  pubmed Chen B, Wu L, Zhang L, Liu M 等 2026 Aug 13 置信度 0.82
• Relaxivity comparison of Gadoteric acid and Gadopiclenol using clinical and reference MRI sequences at 1.5 T.
  Gadolinium-based contrast agents (GBCAs) exhibit variable relaxivity, and accurate relaxivity assessment is essential both for technical characterization and for optimizing clinical protocols. While reference relaxometry sequences are considered the gold stand…
  pubmed Binninger G, Dillenseger JP, Barantin L, Hattat R 等 2026 Aug 13 置信度 0.82
• Real-world Effectiveness and Safety of Lebrikizumab in Atopic Dermatitis: A TREATgermany Analysis.
  Atopic dermatitis (AD) is driven by type 2 inflammation, with interleukin-13 (IL-13) as one of the central operators. Lebrikizumab is a monoclonal antibody that inhibits IL-13 signalling. Adult patients with moderate-to-severe AD who received lebrikizumab in t…
  pubmed Kind B, Pham C, Heinrich L, Honstein T 等 2026 Aug 13 置信度 0.82