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• Impact of oral contraceptives and metformin on advanced lipid phenotyping in polycystic ovary syndrome.
  Combined oral contraceptives (OCPs) and metformin are commonly used in patients with polycystic ovary syndrome (PCOS), who are at elevated risk of dyslipidemia and cardiovascular disease (CVD), but their effects on advanced lipid phenotyping remain unclear.
  pubmed Lee IT, Soffer DE, Remaley AT, Playford MP 等 2026 Aug 3 置信度 0.82
• Mechanisms of Lycium barbarum Treatment in Sepsis-Induced Myocardial Injury: A Network Pharmacology and Experimental Validation Study.
  Lycium barbarum (LB) has long been recognized for its anti-inflammatory and anti-aging properties, with recent evidence suggesting protective effects against myocardial injury. However, its role in sepsis-induced myocardial injury (SIMI) remains unclear. In th…
  pubmed Liu R, Ma C, Tang Y, Bai X 等 2026 Aug 置信度 0.82
• Virtual screening identifies specnuezhenide as a potential therapeutic agent for rosacea via KLK5/TLR4/NF-κB pathway inhibition and metabolic modulation.
  Rosacea is a chronic inflammatory skin condition. Excessive LL-37 is produced when serine protease kallikrein-5 (KLK5) is hyperactivated, contributing to the inflammatory response in rosacea. Thus, inhibition of KLK5 has the potential to attenuate inflammation…
  pubmed Xu J, Li X, Chen M, Di S 等 2026 置信度 0.82
• Trust-driven consensus reaching in human-AI hybrid large-scale group decision-making.
  To address the issues of insufficient trust representation, lack of feedback in opinion conflicts, and low consensus convergence efficiency in human-AI hybrid group decision-making, this paper proposes a trust-driven consensus-reaching method for human-AI coll…
  pubmed Wang X, Xu X, Zhang W 2026 置信度 0.82
• Innovative practice research of empowerment of artificial intelligence into blended teaching in exercise physiology.
  Exercise Physiology is a core course in the physical education major at higher education institutions. In the context of the modern era, leveraging generative artificial intelligence (AI) to reform its teaching framework is crucial for cultivating specialized …
  pubmed Cao J, Xu M, Zhu X, Long Q 2026 置信度 0.82
• Modified clomiphene citrate protocol versus gonadotropin-releasing hormone antagonist protocol in in vitro fertilization: a propensity score-matched retrospective study on cost and efficacy.
  The rising prevalence of infertility has substantially increased the demand for in vitro fertilization (IVF). While various controlled ovarian stimulation (COS) protocols exist, the gonadotropin-releasing hormone antagonist (GnRH-ant) protocol is valued for it…
  pubmed Zhu W, Chen D, Zhan X, Li Q 等 2026 置信度 0.82
• The past, present, and future treatment of BRAF(V600)-mutant metastatic colorectal cancer: A comprehensive review.
  BRAF V600 -mutant metastatic colorectal cancer comprises a biologically distinct and clinically aggressive subset of metastatic colorectal cancer. Early attempts to apply single-agent BRAF V600 inhibition failed because of rapid acquired resistance and reactiv…
  pubmed Dirven I, Ang C, Bertels C, Kortbeek K 等 2026 Aug 15 置信度 0.82
• Hierarchical Model Selection and Control for Latency-Energy Optimization in MEC-Assisted Vehicular Networks.
  Multi-access edge computing (MEC) enables computation-intensive perception and decision-making tasks in vehicular networks to be offloaded to nearby edge servers. Existing approaches usually fix the artificial intelligence (AI) inference model, overlooking how…
  pubmed Song I, Kang S, Ros S, Kim S 2026 置信度 0.82
• TL-RL-FusionNet: Reinforcement Learning-Guided Residual MLP with Fused CNN Embeddings for Efficient and Adaptive Ransomware Detection.
  Ransomware detection remains challenging because modern variants exhibit diverse, elusive, and partly benign behaviors and can propagate rapidly across interconnected enterprises and sensor-enabled cyber-physical systems, causing cascading operational failures…
  pubmed Ferdous J, Islam R, Mahboubi A, Islam MZ 2026 Jul 27 置信度 0.82
• In Vitro Anti-Breast Cancer Effects of Tamarix aphylla-Derived Quercetin and In Silico Insights into Its Targeting of PIP4K2A.
  Phosphatidylinositol 5-phosphate 4-kinase type 2 alpha (PIP4K2A) is a key oncogenic driver that regulates the PI5P/PIP2 axis to promote metastatic migration in breast cancer. This study aimed to investigate the therapeutic potential of a crude extract from Tam…
  pubmed Al-Fahad D, Hashim ZN, Almahmoud SA, Azam F 2026 Aug 6 置信度 0.82
• PKM2 Inhibitors Induce Autophagic Cell Death Through Suppression of PKM2-Mediated Glycolysis in Cisplatin-Resistant Ovarian Cancer Cells.
  Ovarian cancer is among the most lethal gynecological malignancies due to its poor prognosis and lack of early symptoms. Cisplatin remains the primary chemotherapeutic agent; however, resistance to cisplatin in advanced ovarian cancer is a major cause of treat…
  pubmed Park HE, Lee H, Kim JR, Lee E 等 2026 Aug 6 置信度 0.82
• Computationally Generated Plant-Derived Berberine-Based Hybrid Compounds as Potential Dual Binders to Staphylococcus aureus FtsZ/FabI Enzymes: A Ligand-Based Approach.
  Staphylococcus aureus ( S. aureus ) remains a major global pathogen and a significant public health concern due to its antibiotic resistance. This has spurred the search for new treatments, resulting in the discovery of two promising targets: FtsZ and FabI. Na…
  pubmed Robles-Romero JC, Quintero-Vargas J, Ochoa Lara K, Leyva-Peralta MA 等 2026 Aug 5 置信度 0.82
• Targeting IGF2BP3 in Cancer: From Molecular Structure and Biology to Early Drug Discovery.
  RNA-binding proteins (RBPs) remain underexplored as small-molecule targets, although their dysregulation contributes to numerous human diseases, including cancer. RBPs are key regulators of post-transcriptional gene expression, controlling multiple stages of R…
  pubmed Uliassi E, Bolognesi ML, Scotlandi K, Mancarella C 2026 Aug 4 置信度 0.82
• Molecular Mechanisms Underlying Antimicrobial Resistance in Mycobacteria.
  Antimicrobial resistance in mycobacteria arises from a complex interplay of intrinsic and acquired mechanisms that collectively limit the efficacy of current therapeutic options. Intrinsic resistance is largely driven by the low permeability of the mycobacteri…
  pubmed López-Roa P, Esteban J, Muñoz-Egea MC 2026 Aug 1 置信度 0.82
• Identification of Natural Flavonoids Targeting PLK-1 as Potential Anti-Metastatic Agents: A Computational Approach.
  This study combines ligand- and structure-based in silico strategies to predict the inhibitory activity of natural flavonoids on the Polo-Like Kinase-1 (PLK-1) enzyme as candidate anticancer agents. This enzyme participates in mitosis and is overexpressed in c…
  pubmed Cañizares-Carmenate Y, Hernández-Rodríguez EW, Perera-Sardiña Y, Aguado-Herrera DB 等 2026 Jul 29 置信度 0.82
• Mutant-Selective Binding of Phyllanthus niruri Phytochemicals to EGFR T790M: A Quantum-Classical Mechanistic Study.
  Epidermal growth factor receptor (EGFR) mutations drive hepatocellular carcinoma (HCC) progression, and the T790M gatekeeper substitution is the predominant mechanism of acquired resistance to EGFR-targeted therapies. Herein, we present multiscale quantum-clas…
  pubmed Lituma-González WD, Dinesh Kumar D, Arunprasad AV, Verma T 等 2026 Jul 23 置信度 0.82
• Novel Functionalized Pyrrolopyridines to Target Brk.
  Increasing resistance against protein kinase inhibitors used in cancer therapies enforces the search for novel target structures to be addressed with favourable small-molecule inhibitors. One of these novel target structures is the tyrosine kinase Brk that is …
  pubmed Schmidt E, von Veh J, Sarnow AC, Sippl W 等 2026 Aug 6 置信度 0.82
• Eco-Friendly Synthesis, Physicochemical Characterization, and In Vitro Biological Evaluation of Plant-Derived Bioactive-Loaded Chitosan Nanoparticles Supported by Molecular Modeling Studies.
  Silybum marianum (SM) is a rich source of flavonolignans with promising antioxidant and antidiabetic properties; however, its therapeutic application is limited by poor stability and bioavailability. This study combined experimental and computational approache…
  pubmed Ajwa, Hussain F, Jamil A, Aslam B 等 2026 Jul 31 置信度 0.82
• Novel Mechanisms of SARS-CoV-2 Drug Resistance and Rational Design of Anti-Resistant Antivirals.
  Antiviral drug resistance in SARS-CoV-2 is increasingly limiting treatment efficacy. Four recent studies have revealed two key resistance mechanisms: (1) Mutations in the main protease (M pro )-including E166V, E166A, and S144-series variants-disrupt drug bind…
  pubmed Bai X, Ye B, Gao S, Zhan P 等 2026 Jul 30 置信度 0.82
• Unveiling the Role of Mg(2+) and Mn(2+) in Theaflavin-Mediated Inhibition of Advanced Glycation End Products Formation: Mechanistic Insights from Intermolecular Interaction.
  Advanced glycation end products (AGEs) are implicated in the pathogenesis of chronic diseases. This study investigated the inhibitory effect of theaflavin (TA) on AGE formation in a human serum albumin (HSA)-fructose model system, both in the absence and prese…
  pubmed Yuan L, Zhang Y, Liu H, Lu X 等 2026 Jul 29 置信度 0.82
• Design, Synthesis, In Silico ADME, Toxicity Prediction and Molecular Docking Studies of Benzimidazole-Oxadiazole Derivatives for α-Glucosidase and Aldose Reductase Pathways as Potent Anti-Diabetic Agents.
  In this study, due to the side effect profiles and low efficacy of currently used inhibitors, novel benzimidazole-oxadiazole derivatives ( 6a - 6e , 7a - 7e ) were synthesized as dual inhibitors of α-GLY and AR. Their structures were elucidated using 13 …
  pubmed Işık M, Karakaya A, Çevik UA, Necip A 等 2026 Jul 29 置信度 0.82
• Synthesis and Biological Activity of Azolo[a]quinoxalines.
  This review covers published data (mostly from 2019 to 2025) on the synthesis and biological activity of azolo[ a ]quinoxalines, including pyrazolo-, imidazo- and triazolo-annelated systems. We highlight that most research efforts are directed toward the desig…
  pubmed Nosova EV, Lipunova GN, Charushin VN 2026 Jul 24 置信度 0.82
• Essential Oil Derived from Horticultural By-Products of Artemisa dracunculus L.: A Sustainable Source of Bioactive Compounds with Multiple Biological Activities.
  Agricultural and horticultural by-products represent an underexploited source of valuable bioactive compounds that can contribute to the development of more sustainable production systems. This study investigated the chemical composition and biological activit…
  pubmed Polito F, Candido V, Potenza G, Nazzaro F 等 2026 Jul 24 置信度 0.82
• Effects of Co-Cultivation on the Phenolic Composition and Bioactive Properties of Basidiomycete Mycelia: Antioxidant, Photoprotective, Anti-Tyrosinase, and In Silico Evidence.
  Basidiomycetes produce a wide range of bioactive metabolites, yet the effects of fungal co-cultivation on phenolic composition and associated biological properties remain poorly understood. This study investigated the phenolic composition and antioxidant, phot…
  pubmed Avelino KV, Garcez MAP, Giansante RFRF, Halabura MIW 等 2026 Jul 23 置信度 0.82
• Linear Residual Network Modeling for Anti-HIV-1 Activity Prediction and Docking-Validated Design of Biphenyl-DAPY-Based NNRTIs.
  To predict the anti-HIV-1 activity of biphenyl-DAPY-based non-nucleoside reverse transcriptase inhibitors (NNRTIs), a quantitative structure-activity relationship (QSAR) analysis was conducted. Using the heuristic method (HM) for descriptor selection, four pre…
  pubmed Wang H, Zhang Y, Wang A, Zhang P 2026 Jul 23 置信度 0.82
• AI-Guided Cognitive Behavioral Therapy for Depression and Anxiety: Bridging the Mental Health Treatment Gap Through Digital Psychiatry.
  Background: Depression and anxiety disorders remain among the leading contributors to global disability and represent a major public health challenge. Although evidence-based psychotherapies are available, access to treatment remains limited due to structural,…
  pubmed Stojanovic A, Stankovic M, Ristic A 2026 Aug 1 置信度 0.82
• Platelet-Derived Exosome Product Prolongs Stem Cell-Derived β-Cell Graft Survival and Is Associated with Reduced Nk Cell Infiltration and Immunomodulation.
  Stem cell-derived β (SC-β) cells are a promising therapy for type 1 diabetes (T1D), but their long-term efficacy is limited by immune-mediated graft rejection. Platelet-derived exosome product (PEP) has emerged as a novel immunomodulatory agent, al…
  pubmed Khashim Z, Shrestha S, Hassoun S, Law EW 等 2026 Jul 29 置信度 0.82
• Efficacy and safety of BAFF/APRIL-pathway inhibitors versus placebo in adults with IgA nephropathy: a systematic review with pairwise and network meta-analysis.
  B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) drive the galactose-deficient IgA1 (Gd-IgA1) production that underlies IgA nephropathy (IgAN). Several BAFF/APRIL-pathway inhibitors have entered randomized testing, but none has been …
  pubmed Mansour N, Elbarody RMF, Kamel AM 2026 Aug 11 置信度 0.82
• IMD-1 Protects SH-SY5Y Cells Against H(2)O(2)-Induced Oxidative Injury Through Modulation of Oxidative Stress, Mitochondrial Bioenergetics, Inflammatory Mediator Release, and Apoptosis-Related Responses.
  Oxidative stress, mitochondrial dysfunction, inflammation-associated cellular responses, and apoptosis are closely associated with the pathogenesis of neurodegenerative disorders. Therefore, identifying small molecules capable of modulating these interconnecte…
  pubmed Derya-Andeden M, Altin-Celik P, Tokguner NE, Turan A 等 2026 Aug 12 置信度 0.82
• Agentic profiles for effective AI governance.
  The creation of effective governance mechanisms for artificial intelligence (AI) agents requires a deeper understanding of their core properties and the implications they have for deployment. This paper provides a characterization of AI agents that focuses on …
  pubmed Kasirzadeh A, Gabriel I 2026 置信度 0.82
• Longitudinal transcriptomic analysis of mucosa in ulcerative colitis after anti-tumor necrosis factor withdrawal compared to continued treatment.
  Monoclonal antibodies against tumor necrosis factor (anti-TNF) are effective agents in the treatment of moderate-to-severe ulcerative colitis (UC). It is unclear whether such treatment can safely be discontinued without relapse. This study aimed to identify bi…
  pubmed Rapp E, Berset IP, Umu SU, Bækkevold ES 等 2026 Aug 5 置信度 0.82
• Advancing breast cancer clinical management through technological innovation: the potential role of artificial intelligence and integrated care models.
  In health care, artificial intelligence (AI) is emerging as a powerful tool to improve the quality of care, support health care professionals, and build a more streamlined and efficient health care system while also enhancing the patient experience. In particu…
  pubmed Toss A, Bellardita L, Botticelli A, Caputo R 等 2026 Aug 12 置信度 0.82
• Repurposing Alzheimer's and ovarian cancer drugs as sonosensitizers for glioblastoma via a positive-unlabeled learning and 3D bioprinting-based new approach methodology (NAM).
  Glioblastoma (GBM) remains a lethal primary brain tumor, in part because therapeutic efficacy is limited by the blood-brain barrier (BBB) and the complex tumor microenvironment (TME). Sonodynamic therapy (SDT), i.e., use of ultrasound to activate chemical sens…
  pubmed Majumder R, Datta P, Moolayadukkam S, Puri IK 2026 置信度 0.82
• Ferroptosis-Inflammation Crosstalk: Mechanistic Insights and Emerging Drug Targets.
  Ferroptosis, a non-apoptotic form of regulated cell death characterized by iron accumulation and lipid peroxidation, has recently established its crucial role in inflammation and immune - related diseases. The current review aims at offering a comprehensive sy…
  pubmed Gupta S, Mukherjee S 2026 Aug 12 置信度 0.82
• In vitro enzymatic assays invalidate dihydromyricetin as a potential inhibitor against enterovirus A71 3C protease: beware of fluorescence quenching artifacts.
  Enterovirus A71 (EV-A71) is an important pathogen that causes hand, foot, and mouth disease (HFMD) outbreaks worldwide. Although vaccines against EV-A71 have been approved in China, there are currently no efficacious antivirals for HFMD treatment. The 3C prote…
  pubmed Ye J, Zhang M, Zhou J, Xu C 等 2026 Aug 置信度 0.82
• Efficacy and safety of tradipitant in motion sickness: a systematic review and meta-analysis.
  Motion sickness affects up to 30% of the general population, yet the three pharmacological agents currently approved in the United States, dimenhydrinate, meclizine, and scopolamine carry significant sedative and cognitive liabilities and offer incomplete prot…
  pubmed Elsaadouni MR, Aldekhail NH, Alhawamdeh ATA, Eljoujou RM 等 2026 Aug 12 置信度 0.82
• Advanced Nanoencapsulated Essential Oil Materials as Novel Antimicrobials for the Control of Fire Blight in Apple.
  Fire blight, caused by Erwinia amylovora, can cause yield losses of up to 95% in apple and pear orchards. Management commonly relies on antibiotic applications during bloom, which may promote antibiotic resistance. Here, bentonite nanoclay (BNT) composites loa…
  pubmed Brunelli A, Salgado C, Fernandez JF, Zuverza-Mena N 等 2026 Aug 12 置信度 0.82
• Novel Curcumin Derivatives as Potent FtsZ-Targeting Bactericides against Rice Bacterial Leaf Blight.
  Rice bacterial leaf blight (BLB), caused by Xanthomonas oryzae pv. oryzae (Xoo), poses a serious threat to global rice production. Given the critical role of filamentous temperature-sensitive protein Z (FtsZ) in bacterial cell division, thirty-five curcumin de…
  pubmed Wang J, Wang C, Chen P, Liu H 等 2026 Aug 12 置信度 0.82
• Andrographolide inhibits hepatocellular carcinoma progression and programmed death ligand-1 expression by blocking STAT3 phosphorylation.
  Hepatocellular carcinoma (HCC) is an aggressive malignancy with frequent recurrence and strong immune evasion. Programmed death ligand-1 (PD-L1) facilitates immune evasion by suppressing T-cell activity. Andrographolide (AD), a natural diterpenoid with anti-in…
  pubmed Fu H, Yuan Y, Tan J, Pang Y 等 2026 Jul 1 置信度 0.82
• Epidermal growth factor receptor as a target enzyme in cancer therapy: Structural and functional insights from crystallography.
  The epidermal growth factor receptor (EGFR) is a transmembrane receptor tyrosine kinase that plays a central role in regulating cell growth, differentiation, and survival. In non-small cell lung cancer (NSCLC) and several other malignancies, activating mutatio…
  pubmed Magar VK, Khavane K, Wagh A, Shelke S 等 2026 Jul 1 置信度 0.82
• SKP2 in Cancer: From Molecular Regulation to Therapeutic Vulnerabilities and Translational Perspectives.
  The ubiquitin-proteasome system (UPS) plays a central role in regulating protein homeostasis and degradation. Its dysregulation is closely associated with various diseases, including cancer. S-phase kinase-associated protein 2 (SKP2) is a key E3 ubiquitin liga…
  pubmed Zheng SA, Wang C, Yao XD, Sheng JJ 等 2026 置信度 0.82
• From institutional trust to AI adoption: a trust transfer and risk perception model of AI-enabled public service acceptance in China's digital government context.
  Artificial intelligence (AI) is increasingly used in public agencies to route inquiries, screen eligibility, support caseworkers, and automate routine service encounters. Citizen acceptance of these services depends on their links to public authority, accounta…
  pubmed Wang H, Zhu S 2026 置信度 0.82
• Graph-of-Agents: A Graph-based Framework for Multi-Agent LLM Collaboration.
  With an ever-growing zoo of LLMs and benchmarks, the need to orchestrate multiple models for improved task performance has never been more pressing. While frameworks like Mixture-of-Agents (MoA) attempt to coordinate LLMs, they often fall short in terms of (1)…
  pubmed Yun S, Peng J, Li P, Fan W 等 2026 置信度 0.82
• Synthetic T1 mapping using artificial intelligence and oxygenation-sensitive cardiovascular magnetic resonance for myocardial tissue characterization in hypertrophic cardiomyopathy and cardiac amyloidosis.
  Cardiovascular magnetic resonance (CMR) techniques provide detailed myocardial tissue characterization. However, LGE requires the administration of contrast agents, while T1/T2 mapping involves prolonged acquisition times, sensitivity to motion artifacts, and …
  pubmed Lotfikazemi F, Benovoy M, Chetrit M, Luu J 等 2026 置信度 0.82
• DLL3-directed immune redirection in small-cell lung cancer: a lineage-defined vulnerability that doubles as an escape route.
  Delta-like ligand 3 (DLL3) is the first tumor cell surface antigen in small cell lung cancer (SCLC) to support an approved T-cell-redirecting therapy with demonstrated survival benefit, namely the DLL3×CD3 bispecific T-cell engager tarlatamab. DLL3-direct…
  pubmed Wang X, Wang F, Tian W 2026 置信度 0.82
• Component Analysis and Mechanism Exploration of Fangji Dihuang Decoction in Treating Ischemic Stroke With Homotherapy for Heteropathy Based on Molecular Networking and Network Pharmacology.
  Fangji Dihuang Decoction (FJDH), a classic Chinese herbal formula, has historically been used to treat mental disorders. However, current research primarily focuses on clinical applications without analyzing the active components or elucidating modern pharmaco…
  pubmed Yang C, Chen C, Zhang F, Tian X 等 2026 Sep 置信度 0.82
• Effectiveness of brodalumab in biologic-experienced adults with moderate to severe plaque psoriasis: a focused narrative review.
  To summarize recent literature evaluating treatment outcomes in adults with plaque psoriasis who switched to brodalumab from a different biologic because of treatment failure (inadequate initial response/loss of an adequate initial response) and/or adverse eve…
  pubmed Armstrong AW, Strober BE, Liu CM, Cather JC 等 2026 Dec 置信度 0.82
• Acquired resistance to the RAS(ON) multi-selective inhibitor daraxonrasib guides rational combination therapy strategies in pancreatic cancer.
  Daraxonrasib is an orally bioavailable RAS(ON) multi-selective tri-complex inhibitor of the oncogenic mutant and wild-type variants of N, H and KRAS. We previously reported encouraging efficacy in a phase 1/2 clinical trial evaluating daraxonrasib monotherapy …
  pubmed Aronchik I, Kar S, Zhuang Y, Ahler E 等 2026 Aug 置信度 0.82
• Daily briefing: AI agents sniff out decades-old errors in scientific literature.
  pubmed Smith J 2026 Aug 10 置信度 0.82
• Temperature-sensitive liquid embolic agent transarterial chemoembolization versus drug-eluting bead transarterial chemoembolization for BCLC Stage B/C hepatocellular carcinoma: a multicenter real-world study and spatial transcriptomics profiling (CHANCE 2515).
  Transarterial chemoembolization (TACE) remains a cornerstone therapy for intermediate-to-advanced hepatocellular carcinoma (HCC); however, the optimal embolic platform remains uncertain. This multicenter, retrospective, real-world study (Clinical trial registr…
  pubmed Xie Q, Yang Y, Xie S, Yang X 等 2026 Aug 11 置信度 0.82
• Design and Synthesis of Morroniside Derivatives Targeting H(2)O(2)-Induced Oxidative Stress: Antioxidant-Triggered Neuroprotective Effect.
  Oxidative stress drove neuronal damage by disrupting redox homeostasis and played a crucial role in the progression of neurological disorders. Natural antioxidants garnered significant interest as potential therapeutics. Morroniside exhibited promising antioxi…
  pubmed Wang M, Gao H, Song Y, Sun B 等 2026 Aug 14 置信度 0.82
• Exploration of Nirmatrelvir Derivatives as Optimized SARS-CoV-2 Antivirals.
  Nirmatrelvir (NMV) is a SARS-CoV-2 antiviral component of the approved COVID-19 therapeutic Paxlovid. It is a reversible covalent inhibitor of SARS-CoV-2 main protease (M Pro ) that is effluxed from human cells by P-glycoprotein (P-gp). To identify NMV analogs…
  pubmed Alugubelli YR, Vulupala VR, Yang KS, Khatua K 等 2026 Aug 14 置信度 0.82
• Phase I safety, efficacy, and biomarker response evaluations of three oral PD-L1 inhibitors: INCB086550, INCB099280, and INCB099318.
  Orally administered small-molecule programmed death ligand 1 (PD-L1) inhibitors may have the potential to improve patient outcomes in the treatment of a range of cancers compared with their antibody-based counterparts. A small molecule might achieve better tum…
  pubmed Prenen H, Rottey S, Pinato DJ, Lesimple T 等 2026 Aug 11 置信度 0.82
• BLU-945 suppresses ABCB1-mediated drug efflux and restores chemosensitivity in multidrug-resistant cancer cells.
  Chemotherapy remains a cornerstone of cancer treatment, yet its clinical efficacy is often limited by multidrug resistance (MDR). A major contributor to this phenomenon is the ATP-binding cassette transporter ABCB1 (P-glycoprotein; P-gp), which actively export…
  pubmed Wu CP, Li YC, Chen TY, Chuang HC 等 2026 Sep 10 置信度 0.82
• The Allosteric Revolution: From Static Structures to Conformational Ensembles and Next-Generation Therapeutics.
  The rapid emergence of breakthrough allosteric drugs, together with increasing emphasis on the molecular mechanisms of disease, underscores the critical importance of understanding biological processes at the molecular level. Among these, few concepts are as f…
  pubmed Nussinov R, Jang H 2026 置信度 0.82
• A descriptive study of the association of Carbapenem-resistant Enterobacterales with environmental justice of a Southern urban county, USA.
  Carbapenem-resistant Enterobacterales (CRE) present a threat to global public health systems, yet the environmental contribution to antibiotic resistance prevalence has been understudied. The risk of antibiotic-resistant bacterium proliferating may be greater …
  pubmed Beauchamp AM, Ingle TA, Cooper LN, Hanna JJ 等 2026 置信度 0.82
• Finite State Machine-Guided Retrieval-Augmented Generation Improves Expert-Rated Acceptability of a Peripherally Inserted Central Catheter Self-Management Chatbot: Single-Center Content Validation Study.
  Patients with cancer undergoing long-term or vesicant chemotherapy frequently require peripherally inserted central catheters (PICCs). Due to the nature of ambulatory treatment administration, self-PICC management is essential for the continuation and completi…
  pubmed Lee M, Cho SB, Yu JW, Yoon J 等 2026 Aug 11 置信度 0.82
• Poly(2-oxazoline) micelles for co-delivery of paclitaxel and metronidazole benzoate for dual chemotherapeutic and antibacterial targeting in the tumor microenvironment.
  Tumor-resident pathogenic bacteria can promote cancer progression and reduce chemotherapy efficacy, yet strategies to simultaneously target both tumor cells and intratumoral microbes remain limited. Here, we report a poly(2-oxazoline) micelle (POx) platform co…
  pubmed Holden A, Hutsell H, Palchak L, Luo L 等 2026 Aug 11 置信度 0.82
• Superhydrophobic fluorescent carbon quantum dots for AI-enabled anti-counterfeiting and textile coating applications.
  Nature has engineered superhydrophobic materials and applied them as coatings of micro- and nano-scale structures, such as the lotus leaf, facilitating the self-cleaning of dirt, dust, and bacteria. Inspired by nature, a series of superhydrophobic solid-state …
  pubmed Garg S, Kumar D, Sahu BK, Tiwari G 等 2026 Aug 11 置信度 0.82
• Structure-based screening and identification of a novel Aurora-A-targeting peptide with antiproliferative activity against prostate cancer cells.
  Aurora-A is a potential therapeutic target in prostate cancer. In this study, virtual screening identified four Aurora-A-targeting peptides, among which Peptide-1 showed the most favourable profile. Molecular docking and MST assays demonstrated that Peptide-1 …
  pubmed Huang BB, Jiang H, Hu Y, Ge JJ 等 2026 Dec 置信度 0.82
• A dual role for PGLYRP1 in host defense and immune regulation during B. pertussis infection.
  Bordetella pertussis , the etiologic agent of whooping cough, remains a serious public health concern despite widespread vaccination. Improved therapeutics and vaccines are urgently needed. Host recognition of bacterial peptidoglycan (PGN), including B. pertus…
  pubmed Rickert DM, Cardozo S, Carbonetti N, Goldman WE 等 2026 Aug 11 置信度 0.82
• Elevated Histamine Receptor 2 and Toll-Like Receptor 7 Expression in Rheumatoid Arthritis: Insights Into Inflammatory Mechanisms and Potential Therapeutic Strategies.
  Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and joint damage. Toll-like receptor 7 (TLR7), one of the innate immunity receptors, plays a role in releasing inflammatory mediators like cytokines and…
  pubmed Kamil Al-Basri A, Sedighi S, Bagheri Y, Saghaiyan Jazi M 等 2026 Aug 置信度 0.82
• Discovery of Pancreatic Lipase Inhibitory and Antimicrobial Constituents in Crataegi Folium by High-Performance Thin-Layer Chromatography-Bioautography-Mass Spectrometry.
  Crataegi Folium (CF), a traditional Chinese medicine widely used for promoting blood circulation and regulating lipid metabolism, contains diverse bioactive constituents with potential health-promoting effects. However, the rapid localization and identificatio…
  pubmed Zhu L, Ma AL, Zhang YL, Si ZH 等 2026 Aug 置信度 0.82
• PRIME: Planning and Retrieval-Integrated Memory for Enhanced Reasoning.
  Inspired by the dual-process theory of human cognition from Thinking, Fast and Slow , we introduce PRIME (Planning and Retrieval-Integrated Memory for Enhanced Reasoning), a multi-agent reasoning framework that dynamically integrates System 1 (fast, intuitive …
  pubmed Tran H, Yao Z, Luong Tran N, Yang Z 等 2026 置信度 0.82
• AI-driven Diagnostics, Phytocompound-based Therapeutics and Novel Approaches for Intracerebral Haemorrhage: A Systematic Review.
  Intracerebral Haemorrhage (ICH) is one of the most deadly forms of stroke, with a high risk of morbidity and fatality. Due to increased anticoagulant use over the past four decades, the global incidence of hemorrhagic stroke has increased. Chronic hypertension…
  pubmed Nooreen Z, Wal A, Ojha M, Shukla MM 等 2026 Jul 28 置信度 0.82
• A comprehensive look at Respiratory Syncytial Virus (RSV): from pathogenesis to prevention.
  Respiratory Syncytial Virus (RSV) is a formidable respiratory pathogen that particularly affects infants and children. RSV presents with diverse clinical severity, most often causing mild upper airway symptoms but sometimes progressing to severe and potentiall…
  pubmed Salahi Ardekani O, Hasannezhad P, Goudarzi Y, Letafati A 等 2026 Aug 8 置信度 0.82
• Brazilin From Biancaea sappan as a Multi-Target Candidate in Thalassaemia: Mechanistic Insights Into Iron Chelation, Antioxidant Activity, and Potential JAK2 Modulation.
  Thalassaemia is a hereditary haemoglobinopathy characterised by impaired globin synthesis, resulting in ineffective erythropoiesis and systemic iron overload. While current management relies on blood transfusions and chelation, these often fail to address the …
  pubmed Youngest R, Kamisah Y, Safitri R, Maskoen AM 2026 Aug 置信度 0.82
• The History of the Discovery of Vitamin K.
  Vitamin K was discovered during the 1930s when a strange haemorrhagic disorder was observed in chickens fed a cholesterol-free diet. A fat-soluble agent, present in green leafy vegetables and hog liver, was able to restore haemostasis in the chickens. The chem…
  pubmed Tuxen HN, Zwisler L, Linneberg A 2026 Sep 置信度 0.82
• Whole-blood coagulation and platelet dynamics identify differential prothrombotic states in patients with rheumatoid arthritis treated with JAK or TNF-ɑ inhibitors.
  Rheumatoid arthritis (RA) is associated with inflammation-driven hypercoagulability and increased venous thromboembolic risk. Post hoc analyses of safety trials have raised concerns regarding a potential differential thrombotic risk with Janus kinase inhibitor…
  pubmed Giollo A, Di Luozzo L, Salvato M, Khalid K 等 2026 Aug 10 置信度 0.82
• Phosgene inhalation injury in mice: Modeling human pathophysiology, biomarker discovery, and therapeutic target identification.
  Phosgene gas, also known as choking gas (CG; military designation), has been used in warfare and terrorism and remains a major industrial and transportation hazard. Phosgene inhalation causes severe pulmonary edema, acute lung injury, and high mortality; howev…
  pubmed Long SM, Caceres AI, Marcus AD, Daly JM 等 2026 Oct 置信度 0.82
• Beyond BCL-2: What drives venetoclax resistance in acute myeloid leukemia?
  The BCL-2 inhibitor venetoclax has transformed outcomes for older or frail patients with acute myeloid leukemia (AML), and its resistance mechanisms are becoming better defined, including compensatory and lineage-associated switches toward MCL-1 or BCL-xL depe…
  pubmed Skwarska A, Konopleva M 2026 Aug 10 置信度 0.82
• A local, privacy-oriented multi-agent LLM framework for framework-grounded manuscript editing: A proof-of-concept.
  Manuscript preparation is a bottleneck in publishing, and cloud-based AI tools raise confidentiality concerns for clinical researchers. We developed the Paper Analysis Tool (PAT), a free, multi-agent framework that audits manuscripts with a local open-weight l…
  pubmed Gorenshtein A, Bhansali R, Westover B, Goldenholz DM 2026 置信度 0.82
• Artificial intelligence in medical education: a narrative review across four functional domains.
  Artificial intelligence (AI) is increasingly reshaping medical and health-professions education through adaptive tutoring, generative content creation, simulation analytics, automated assessment, and diagnostic-reasoning support. Since 2023, large language mod…
  pubmed Zarei M, Mozaffari M, Hajiani Y 2026 Aug 10 置信度 0.82
• A sequential photodynamic-antioxidation therapy against Alzheimer's β-amyloid enabled by a dual‑carbon dots nanomotor.
  Abnormal accumulation of β-amyloid protein (Aβ) in the brain is considered as the primary hallmark of Alzheimer's disease (AD). Beyond inducing neuronal metabolic disorders and apoptosis, Aβ activates oxidative stress pathways, thereby exacer…
  pubmed Lin X, Wei Z, Dong X, Sun Y 2026 Dec 15 置信度 0.82
• 3-amino-1,2,4-triazine scaffolds as next-generation PDK inhibitors: Design, mechanistic insights, and efficacy in pancreatic ductal adenocarcinoma.
  Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer characterized by late diagnosis, aggressiveness, metabolic plasticity, and resistance to therapy, underscoring the need for new molecular targets. Pyruvate dehydrogenase kinases (PDKs), particul…
  pubmed Carbone D, Biancucci C, De Franco M, Pecoraro C 等 2026 Nov 15 置信度 0.82
• Light-Driven Antimicrobial Cotton Fabric: Multilayer Dye-Finishing Design and Hospital Environment Validation.
  A sequential ionic multilayer finishing strategy enabled the stable co-immobilization of two photosensitizing dyes-cationic methylene blue (MB) and anionic Rose Bengal (RB)-onto cotton fabrics, overcoming cellulose-dye incompatibility through chitosan interlay…
  pubmed Martínez-González I, Gisbert-Payá J, Marin ML, Delgado SG 等 2026 Aug 19 置信度 0.82
• Cascading damage to Candida albicans cells through thioredoxin reductase loss.
  Candida albicans is the most common invasive human fungal pathogen. We show that C. albicans thioredoxin reductase, Trr1, is an attractive antifungal target: it is essential at human body temperature, and fungal and human thioredoxin reductases are structurall…
  pubmed Qi W, Roy U, Cai C, Acosta-Zaldívar M 等 2026 Aug 18 置信度 0.82
• Ex vivo tumor derived organoid pharmacotyping identifies personalized therapeutic options for biliary tract cancer patients.
  Biliary tract cancers (BTCs) pose clinical challenges due to poor chemotherapy response and aggressive disease course. We evaluated patient derived tumor organoid (PDTO) based drug sensitivity testing as a tool to guide therapy. In this multicenter study, 26 t…
  pubmed Richardson AB, Chatterjee P, Rosati R, Rajewski A 等 2026 Aug 10 置信度 0.82
• Targeting CDK-2 With Novel Indole-Pyrazole Hybrids: Discovery of Potent Anticancer Agents Supported by Mechanistic and In Silico Studies.
  The current study devised and synthesized a novel class of pyrazole derivatives based on indole as possible inhibitors of cyclin-dependent kinase-2 (CDK-2). 1 H NMR, 13 C NMR, NOESY, HMQC, and elemental analysis were used to confirm the structural integrity of…
  pubmed Eldehna WM, Elsayed ZM, Elnagar MR, Omar YM 等 2026 Aug 置信度 0.82
• Towards Structural Restoration: Epigenetic Reprogramming and Direct Astrocyte-to-Neuron Lineage Conversion as Next-Generation Regenerative Neurotherapeutics.
  While the recent clinical approval of amyloid-targeting monoclonal antibodies represents a landmark in Alzheimer's disease (AD) management, these immunotherapies fundamentally function as agents of mitigation rather than restoration, failing to reconstitute de…
  pubmed Nguyen HM, Nguyen LDT 2026 Aug 10 置信度 0.82
• Toward microbiota-friendly design and evaluation of antimicrobial peptides: a mini-review.
  The rise of multidrug-resistant (MDR) bacteria driven by the prolonged use and misuse of conventional antibiotics poses a severe threat to global healthcare systems. To combat this risk, considerable research efforts have focused on the discovery of new antiba…
  pubmed Alrashdan A 2026 Aug 10 置信度 0.82
• Semaglutide as a potential neuroprotective agent for neurological and neurodegenerative disorders: Mechanisms, preclinical evidence, and translational challenges and opportunities.
  Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are established treatments for metabolic disease, with growing evidence suggesting neuroprotective potential in central nervous system (CNS) disorders. In preclinical models of Alzheimer's disease (AD), Par…
  pubmed Mukim RD, Xu Y, Evola V, Parmar MS 2026 Aug 10 置信度 0.82
• Advances in extraction, structural characterization, and bioactivities of Armillaria mellea polysaccharides: insights into structure-activity relationships and future applications.
  Armillaria mellea is an edible and medicinal fungus rich in bioactive polysaccharides (AMPs), which have attracted increasing attention due to their diverse pharmacological activities and potential applications in functional foods and pharmaceuticals. This rev…
  pubmed Ai L, Song Y, Qiao Y, Gao M 等 2026 Aug 10 置信度 0.82
• Modelling the 5-Year Impact of Twice-Yearly Injectable Lenacapavir for HIV Pre-Exposure Prophylaxis in the United States.
  The impact of pre-exposure prophylaxis (PrEP) on the US HIV-1 epidemic has not been fully maximized, potentially due to challenges in uptake, coverage, adherence and consistent use. Following the FDA (Food and Drug Adminstration) approval of twice-yearly lenac…
  pubmed Moore M, Lee S, Matrajt L, Stansfield SE 等 2026 Aug 置信度 0.82
• From Dynamics to Diagnosis and Therapy: A Multiscale Computational Framework for MALT1-Targeted Cancer Theranostics.
  Cancer is one of the leading causes of death worldwide, making it a major concern in modern society. Therefore, the proposal of strategies against this illness is of major importance and has been widely studied by the scientific community in the past decades. …
  pubmed Santos RM, Ramalho TC 2026 Aug 10 置信度 0.82
• Glucagon-like peptide-1 receptor agonist-based regimens compared with metformin-based regimens for preventing cardiovascular disease in adults with type 2 diabetes mellitus.
  This is a protocol for a Cochrane review (intervention). The objectives are as follows: To assess the clinical benefits and adverse effects of glucagon-like peptide-1 receptor agonist-based regimens, compared with metformin-based glucose-lowering regimens, for…
  pubmed Ahmed S, McCollin SP, Martí-Carvajal A, Akus M 等 2026 Aug 10 置信度 0.82
• A Systems Pharmacology Model of Aging Identifies Optimal Combination Therapies With Secondary Benefits on Weight Loss and Metabolic Health.
  Aging is a systems-level process linking metabolic dysfunction, inflammation, impaired repair, frailty, and multimorbidity, whereas existing pharmacological strategies usually optimize disease-specific endpoints such as weight loss or HbA1c rather than aging-r…
  pubmed Goryanin I, Damms B 2026 Aug 置信度 0.82
• Precision Medicine in Transfusion-Dependent and Non-Transfusion-Dependent β-Thalassemia: Toward Personalized Diagnosis and Therapy.
  β-thalassemia comprises a clinically heterogeneous group of disorders in which anemia severity, transfusion exposure, iron loading, and organ complications vary widely among individuals. This structured narrative review summarizes practical applications …
  pubmed Karen AA, Tluli O, Hashem IE, Barhoma AM 等 2026 Aug 10 置信度 0.82
• Synergy between orally bioavailable antibiotics and dalbavancin against MRSA.
  We have shown that dalbavancin exposure can select for mutants with reduced susceptibilities to vancomycin and daptomycin, and several clinical cases of such resistance have been documented. Synergistic antimicrobial combinations may reduce resistance selectio…
  pubmed Ahrendt E, Foreman MCL, Werth BJ 2026 Aug 4 置信度 0.82
• QSAR, molecular dynamics, and biological evaluation of novel myeloperoxidase inhibitors via ligand-based pharmacophore modeling as potential anticancer agents.
  Myeloperoxidase (MPO) has shown promise as a therapeutic target due to its critical role in inflammatory mechanisms and cancer progression. Despite extensive research on MPO inhibitors, the lack of integrated computational-experimental workflows constrains the…
  pubmed Alnajdawi MR, Wahab HA, Al-Najjar BO, Aldeeb ID 等 2026 Aug 10 置信度 0.82
• Discovery of a novel 1H-pyrazole-3-amine derivative 6h with potent antitumor activity by targeting tubulin and FLT3.
  A novel series of 1H-pyrazole-3-amine derivatives was designed, synthesized, and their antitumor activities were evaluated. Among them, 6h showed potent antiproliferative activity against solid tumor cell lines and leukemia cell lines, with IC 50 values rangin…
  pubmed Dou BK, Ma XY, Zhang XF, Cui YJ 2026 Nov 15 置信度 0.82
• From invasive nuisance to biotechnological asset: LC-MS/MS chemical profiling and pharmacological potential of ascidian Styela plicata from Albufeira Lagoon, Portugal.
  The invasive ascidian Styela plicata represents a major biofouling challenge in mussel aquaculture systems but also a potential source of bioactive marine metabolites. This study explores the chemical and biotechnological potential of S. plicata collected from…
  pubmed Nunes MJ, Luís CM, Marques V, Gonçalves B 等 2026 Jul 置信度 0.82
• Enhanced Activity of Eugenol Pickering Emulsion Using Lactoferrin-Chlorogenic Acid Complex as a Green Stabilizer.
  Exploiting natural and bioactive stabilizers to fabricate green emulsions has attracted increasing attention. In this work, lactoferrin (LF) was combined with chlorogenic acid (CGA) to construct the LF-CGA complex to prepare a eugenol (EG) Pickering emulsion (…
  pubmed Dong X, Liu T, Li M, Wang X 等 2026 Aug 置信度 0.82
• Unfolding the Pharmacological Potentialities and Phytochemical Characterization of Pajanelia longifolia (Wild) Leaves: A Multidimensional Study via GC-MS/MS, In Vitro, In Vivo, and In Silico Approaches.
  Pajanelia longifolia (Willd.) is a traditionally used medicinal plant with limited scientific evidence regarding its phytochemical composition and pharmacological properties. This study aimed to characterize the phytochemical constituents of P. longifolia leav…
  pubmed Karim MR, Hossain MA, Shamim M, Hosen MR 等 2026 Aug 置信度 0.82
• Patient-Specific Deep Reinforcement Learning for Proton Beam Delivery Under Inter-Phase Variations.
  Proton therapy is challenged by tumor motion, particularly for lung tumors affected by respiratory-induced motion. Conventional planning strategies compensate for this motion by introducing safety margins or by using robust optimization, increasing irradiation…
  pubmed Ghislain M, Loÿen E, Aspeel A, Dasnoy-Sumell D 等 2026 Sep 置信度 0.82
• Association between AI-driven conversational agents and physician-patient interaction quality during outpatient consultations: A propensity score matching study in China.
  This study aimed to use a propensity score matching (PSM) design to examine the association between artificial intelligence (AI)-driven conversational agents (CAs) and physician-patient interaction quality during outpatient consultations.
  pubmed Li D, Zhang H, Lu C 2026 Jan-Dec 置信度 0.82
• The KRAS targeting revolution in metastatic pancreatic cancer: insights from the landmark RASolute-302 trial and emerging allele-specific strategies at ASCO 2026.
  Survival in metastatic pancreatic ductal adenocarcinoma (mPDAC) has long been limited by a dismal second-line therapeutic ceiling dictated by conventional chemotherapy. However, breakthrough data from the ASCO 2026 Annual Meeting and the publication of the pha…
  pubmed Pillozzi S, Giommoni E, Petroni G, Rossini D 等 2026 Aug 8 置信度 0.82
• Agent-Testing Agent: A Meta-Agent for Automated Testing and Evaluation of Conversational AI Agents
  crossref Sameer Komoravolu, Khalil Mrini 2026-03-23T20:23:46Z 置信度 0.70
• Democratic AI Governance
  On July 5, 2023, New York City implemented what many hailed as a landmark achievement in algorithmic accountability. Local Law 144, discussed in the previous chapter, passed after years of advocacy. This law required every employer in the city using automated …
  crossref Chirag Shah 2026-05-25T07:43:58Z 置信度 0.70
• 159Chapter 7 The Importance of AI Agent Frameworks
  crossref B. Subashini, B. Sundaravadivazhagan, S. R Raja, N. Gnanasankaran 2026-07-20T15:22:12Z 置信度 0.70