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• AI agents in drug discovery: A review of evolution, applications, and future directions.
  Artificial intelligence (AI) agents represent a paradigm shift in pharmaceutical research, moving the field from narrow drug-protein affinity modeling toward systems-biology-level evaluation in which autonomous, multi-domain agents combine pattern recognition …
  pubmed Das S, Ferdaus MM, Dam T 2026 Jul 9 置信度 0.82
• A dual self-regulatory platform for programmable biosynthesis of L-lysine-derived alkaloids.
  L-lysine-derived alkaloids represent a structurally diverse and pharmacologically significant class of nitrogen-containing natural products with broad utility as pharmaceutical agents and industrial platform chemicals. However, their microbial biosynthesis has…
  pubmed Lin P, Lee SY 2026 Jul 28 置信度 0.82
• Integrated multi-omics profiling reveals the role of the cfa gene in mediating penicillin antibiotics resistance and stress adaptability in Shigella sonnei.
  Shigella is the pathogen of bacterial dysentery. With the widespread use of antibiotics, the burden of antibiotic resistance in Shigella has become increasingly pronounced. In this study, the cfa gene of ampicillin-resistant strain (Res) was knocked out and ba…
  pubmed Geng J, Gao Y, Su W, Long J 等 2026 Jul 18 置信度 0.82
• Lonicera trichosantha alleviates LPS-induced endometritis in mice by modulating the gut microbiota and host metabolism.
  Endometritis is an inflammatory disorder of the endometrial lining. Conventional antibiotic therapy often fails to control the accompanying disruptive inflammation. The 95 % ethanol-eluted fraction of Lonicera trichosantha (95 %-LT), exhibits potent anti-infla…
  pubmed Chen Z, Li W, Wang M, Li Y 等 2026 Sep 置信度 0.82
• Agentic AI-enhanced digital twins for Smart City civil infrastructure: A secure, autonomous and auditable management framework.
  Smart city implementation increasingly relies on sensing and analytics; however, a persistent operational gap remains between anomaly detection and safe, timely, and accountable intervention in civil infrastructure systems. This paper proposes an Agentic AI-su…
  pubmed Syed TA, Akarma A, Alatify A, Naqash MT 等 2026 置信度 0.82
• Autonomous radiotherapy planning via agentic orchestration using a multimodal TPS-integrated compound AI platform.
  Purpose. Radiation therapy (RT) treatment planning requires iterative, multi-day optimization workflows in which subjective planning strategies produce inter-planner variability in plan quality. Existing computational approaches automate isolated aspects of th…
  pubmed Matthew Maniscalco A, Kyun Park Y, Domal SJ, Lin MH 等 2026 Dec 31 置信度 0.82
• The role of ferroptosis in the pathogenesis and treatment of breast cancer.
  Breast cancer remains one of the most prevalent malignancies and a leading cause of cancer-related mortality among women worldwide. Despite significant advancements in therapeutic strategies, including surgery, radiotherapy, chemotherapy, and targeted therapy,…
  pubmed Zhang M, Han Q, Zhao X, Liu W 等 2026 Jul 15 置信度 0.82
• Interpretable agentic AI system with localized reasoning for radiology.
  Medical AI has produced many radiology models, particularly for chest X-rays (CXR), each excelling at isolated tasks like lesion detection or report generation. However, these models have disparate capabilities and limited generalizability due to training on r…
  pubmed Chen W, Dong Y, Ding Z, Shi Y 等 2026 Jul 15 置信度 0.82
• CXRAgent: Director-Orchestrated Multi-Stage Reasoning for Chest X-Ray Interpretation.
  Chest X-ray (CXR) plays a pivotal role in clinical diagnosis, and a variety of task-specific and foundation models have been developed for CXR interpretation. However, these models often struggle to adapt to new diagnostic tasks and complex reasoning scenarios…
  pubmed Lou J, Yang Y, Yu Z, Fu Z 等 2026 Jul 15 置信度 0.82
• A framework for longitudinal health AI agents.
  Although artificial intelligence (AI) agents are increasingly proposed to support potentially longitudinal health tasks, such as symptom management, behaviour change and patient support, most current implementations fall short of facilitating user intent and f…
  pubmed Lin G, Jiang R, Elhadad N, Xu X' 2026 May 22 置信度 0.82
• Bioenergetics-Driven Extracellular Vesicle Therapies for Heart Failure: From Preclinical Insights to Regenerative Translation.
  Heart failure (HF) is fundamentally a disease of energetic insufficiency, in which impaired mitochondrial efficiency, maladaptive metabolic remodeling, and disrupted intercellular signaling converge at the organ level to limit cardiac performance. Despite adva…
  pubmed Shahannaz DC, Sugiura T 2026 Jun 29 置信度 0.82
• The Next Paradigm in Medical AI: A Survey of Agentic AI in Biomedicine.
  Biomedical AI is increasingly shaped by policy-bound, multi-step clinical workflows and non-stationary, multimodal data and tools. In this setting, the field is moving beyond static predictors toward agentic systems, enabled by foundation models that maintain …
  pubmed Abdollahi A, Rezaei MA, Wang X, Cai D 等 2026 Jul 13 置信度 0.82
• Mineral and Bone Disease in CKD and Kidney Transplantation: Controversies, Gaps, and a Path Forward.
  The pathophysiology of chronic kidney disease (CKD)-related mineral and bone disorder (CKD-MBD) extends far beyond simple mineral imbalances. Evolving from the traditional understanding of secondary hyperparathyroidism, the conceptual framework has recently be…
  pubmed Kanbay M, Aktas O, Copur S, Drueke TB 等 2026 Sep 置信度 0.82
• The mtROS-Mitophagy Axis: A Decisive Redox Hub Governing Cell Fate in Myocardial Ischemia-Reperfusion Injury.
  The progression of myocardial ischemia-reperfusion injury (MIRI) is orchestrated by a decisive, bidirectional dialogue between mitochondrial reactive oxygen species (mtROS) and mitophagy. This review advances the concept of a dynamic "mtROS-mitophagy axis" as …
  pubmed Wang W, Xu Z, Liu W, Kang Y 等 2026 Jul 11 置信度 0.82
• MARCH: Multi-Agent Radiology Clinical Hierarchy for CT Report Generation.
  Automated 3D radiology report generation often suffers from clinical hallucinations and a lack of the iterative verification found in human practice. While recent Vision-Language Models (VLMs) have advanced the field, they typically operate as monolithic "blac…
  pubmed Lin Y, Ding Y, Wu Y, Peng Y 2026 Jul 置信度 0.82
• Metamorphosis of HOSA: from consumable nitrogen donors to transient directing hubs for switchable divergent synthesis.
  For decades, hydroxylamine- O -sulfonic acid (HOSA) was relegated to the periphery of organic synthesis as a rudimentary, consumable electrophilic aminating agent. Recently, the strategic exploitation of its highly polarized N-O bond and exceptional sulfate le…
  pubmed Luo J, Chen L, Zeng X, Zhang J 等 2026 Jul 29 置信度 0.82
• Materials advances in GTR membrane: A comprehensive review.
  Guided Tissue Regeneration (GTR) is an important part of periodontal therapy. It uses barrier membranes to selectively direct the regeneration of lost periodontal structures. The effectiveness of GTR is mainly based on the natural properties of the materials t…
  pubmed Zaman R, Ismail NH, Awang RA, Khan TA 等 2026 Aug 置信度 0.82
• Glycyrrhiza extract alleviates hemorrhagic septicemia in Triplophysa yarkandensis infected with Shewanella putrefaciens: integrated bactericidal and immunomodulatory effects.
  Intensive saline-alkaline aquaculture has made Shewanella putrefaciens a lethal opportunistic pathogen threatening the indigenous economic fish Triplophysa yarkandensis , and antibiotic overuse poses severe ecological risks to this fragile ecosystem. The immun…
  pubmed Lu H, Tong Y, Zhu W, Chen H 等 2026 置信度 0.82
• Fisetin attenuates CCl₄-induced liver fibrosis through modulation of TGF-β1/Smad3 and p53/Bax/Bcl-2 signaling pathways.
  Liver fibrosis arises from a sustained imbalance between oxidative stress, cell death, and matrix deposition. Using the carbon tetrachloride (CCl 4 ) mouse model, we show that the dietary flavonoid, fisetin orchestrates a broad hepatoprotective program that bl…
  pubmed Sarabandi S, Cordani M, Allameh A 2026 Jul 11 置信度 0.82
• Ligand-resolved in vivo phosphoproteomics of the adult heart maps ErbB signaling by EGF and NRG1β.
  ErbB receptor tyrosine kinases orchestrate phosphorylation-based signaling in response to extracellular ligands and are key drivers in cancer biology. Although ErbB-targeted therapies have transformed cancer care, some agents cause cardiac adverse events. Yet,…
  pubmed Torres Vega E, Douglas Galsgaard K, Skjoldan Svenningsen M, Juul Holst J 等 2026 Aug 置信度 0.82
• Autonomous biomedical research with an artificial intelligence agent.
  Biomedical research is increasingly constrained by repetitive, fragmented workflows that slow discovery. We introduce Biomni, a general-purpose biomedical artificial intelligence agent that autonomously executes diverse research tasks. To map the biomedical ac…
  pubmed Huang K, Zhang S, Wang H, Qu Y 等 2026 Jul 9 置信度 0.82
• Menaquinone-7 alleviates mitochondrial dysfunction and senescence in senile osteoporosis by targeting the PINK1-mediated mitophagy via PXR/ERK/CREB signaling pathway.
  Current therapeutic strategies for senile osteoporosis inadequately address its low-turnover pathology driven by mitochondrial dysfunction and cellular senescence. This study identifies menaquinone-7 (MK-7), a vitamin K 2 isoform, as a novel therapeutic agent …
  pubmed Xu Y, Zhang W, Xu W, Li S 等 2026 Jun 置信度 0.82
• Membrane-Confined Proton Management Orchestrates Proton-Electron Transfer for Efficient Photocatalytic Hydrogen Peroxide Synthesis.
  Coordinating proton and electron transport remains a central challenge in photocatalysis, particularly for H 2 O 2 synthesis, where two-electron oxygen reduction requires synchronized proton delivery and charge transfer. Here, we report hydroxyl-functionalized…
  pubmed Xing Z, Qiao C, Ren K, Su H 等 2026 Jul 9 置信度 0.82
• Structured Large Language Model Workflows for Motivational Interviewing in Health Behavior Change: Proof-of-Concept Study.
  Motivational interviewing (MI) is an effective approach for supporting health behaviorchange, but face-to-face delivery is resource-intensive and difficult to scale. Rule-based conversational agents (CAs) can improve access; however, their scripted interaction…
  pubmed Shenoi A, Li T, Jabir AI, Pitkethly A 等 2026 Jul 6 置信度 0.82
• Reinforcement learning driven edge-cloud coordination for secure and energy efficient IoMT.
  The Internet of Medical Things (IoMT) enables sophisticated medical devices, but it also poses significant challenges in terms of data privacy, real-time processing, and energy efficiency for edge devices with limited resources. In this paper, we propose a hie…
  pubmed Sasikumar SK, Pai TV, Kalidasan K, Gajendran S 2026 置信度 0.82
• Histone lactylation-driven IGF2BP3 promotes intrahepatic cholangiocarcinoma progression via SPP1/CD44-dependent macrophage polarization.
  The tumor microenvironment is a critical regulator of cancer progression. Histone lactylation, a novel post-translational modification, has emerged as a key player in various tumors and is closely linked to macrophage polarization within the immune tumor micro…
  pubmed Lang Q, Yin Z, Sun J, Wang Y 等 2026 Aug 置信度 0.82
• Photobiomodulation and Biological Pathways in Skin Regeneration and Rejuvenation: Light and Biological Activation of Skin Improvement.
  Photobiomodulation harnesses visible and near-infrared wavelengths to modulate mitochondrial energetics and transcriptional programs that orchestrate wound repair, immune homeostasis, angiogenesis, and organized extracellular matrix remodeling. In parallel, to…
  pubmed Khalifian S, Shisler J 2026 Aug 置信度 0.82
• Inorganic biomaterials-reinforced printable hydrogel modulating regenerative microenvironments for tissue repair.
  Complex tissue/organ regeneration is a well-orchestrated biological process that is orchestrated by the coordinated effort of neural, vascular and immune systems, accompanied by multiple cellular interactions and signal crosstalk. The beneficial pro-regenerati…
  pubmed Zhao Z, Wu C 2026 Jul 16 置信度 0.82
• Long noncoding RNAs mediate endocrine signaling and resistance in prostate cancer.
  Prostate cancer (PCa) represents a hormone-dependent malignancy where androgen receptor (AR) signaling plays a central role in disease initiation, progression, and therapeutic resistance. Recent advances have revealed that long noncoding RNAs (lncRNAs) constit…
  pubmed Gioeli D 2026 Jul 8 置信度 0.82
• Towards the construction of a virtual yeast.
  To advance the computational simulation of cellular life, we propose a virtual yeast, an artificial intelligence (AI)-driven agent that models eukaryotic cellular behaviours by integrating multimodal biological data, mechanistic reasoning and active experiment…
  pubmed Qian L, Zhou Z, Zhou P, Dong Z 等 2026 Jul 置信度 0.82
• Pathology-Targeted Nanoparticles Guided by Peptide Remodel the Periodontal Microenvironment for Periodontitis Therapy.
  Periodontitis is an inflammatory and destructive condition, conventional therapies yield inadequate long-term efficacy and possess limited regenerative potential, while the diseased microenvironment driven by inflammation and oxidative stress further hampers t…
  pubmed Wang H, Miao D, Yan T, Zhang Y 等 2026 Jul 置信度 0.82
• Multiphasic blood transcriptomic signatures of radioprotection by BIO 300, a synthetic genistein nanosuspension, in a nonhuman primate model of acute radiation syndrome.
  Prophylactic radioprotectors for pre-exposure administration are notably absent, creating a critical gap in radiation emergency preparedness and ARS management. BIO 300, a wet-nanomilled formulation of synthetic genistein, is in advanced development as a proph…
  pubmed Nanoth Vellichirammal N, Wise SY, Fatanmi OO, Mingus RC 等 2026 Jun 30 置信度 0.82
• Targeting lymphotoxin β receptor: from mechanism to precision therapy.
  The tumour necrosis factor receptor superfamily (TNFRSF) represents a pivotal signalling network that orchestrates immune homeostasis and regulates cell fate decisions. Lymphotoxin β receptor (LTβR, TNFRSF3), a key TNFRSF member, is predominantly e…
  pubmed Zheng P, Dai J, Zheng X, Jiang J 2026 Dec 置信度 0.82
• A LECT2-eluting in situ coaxial electrospun nanofiber dressing orchestrates oxidative stress resolution and immune reprogramming for accelerated wound healing.
  The development of multifunctional dressings capable of actively orchestrating the complex wound microenvironment remains a critical challenge in regenerative medicine. Although leucocyte cell-derived chemotaxin-2 (LECT2) has been implicated in inflammation an…
  pubmed Zheng Z, Mao J, Zhu H, Fu Z 等 2026 Aug 置信度 0.82
• Glycocalyx disruption mediates HP-PRRSV-induced microvascular endothelial dysfunction and underlies astragalus polysaccharide's antiviral efficacy.
  Pulmonary microvascular endothelial cells (MVECs) are not only targets of the highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) but also the pivotal hub of inflammation, interacting with alveolar macrophages to amplify the inflam…
  pubmed Xia N, Sun J, Hu G, Zhang Q 等 2026 Jan 置信度 0.82
• TAF15-mediated m5C modification of MTHFD2 RNA reveals a novel therapeutic target for IDH mutant gliomas.
  IDH mutant gliomas, driven by the oncometabolite 2-hydroxyglutarate (2-HG), are associated with profound neurological morbidity and premature mortality. To address the unmet therapeutic needs, we investigated the mechanistic interplay between MTHFD2-driven one…
  pubmed Wu R, Zhang L, Wong PJ, Sun C 等 2026 Jun 29 置信度 0.82
• An LLM-agent-based framework for calculating nodal carbon intensity in regional power systems.
  Regional carbon-aware operation requires nodal carbon intensity (NCI) signals that remain valid under heterogeneous operational inputs, topology changes, and network congestion; however, existing workflows for carbon-flow tracing and marginal-emission analysis…
  pubmed Zhao J, Chen R, Jiang H, Huang Y 等 2026 Jun 29 置信度 0.82
• Acinar-ductal metaplasia in pancreatitis and pancreatic ductal adenocarcinoma.
  Acinar-ductal metaplasia (ADM) represents a dynamic and reversible cellular adaptation in the pancreas, whereby acinar cells dedifferentiate and transdifferentiate into duct-like cells in response to inflammatory, metabolic, and environmental stressors. While …
  pubmed Zhang X, Zhao Y, Qin C, Li Z 等 2026 Jun 29 置信度 0.82
• Post-transcriptional regulation in cancer chemoresistance.
  Cancer remains the second leading cause of death worldwide, surpassed only by cardiovascular diseases. Although cancer-specific mortality rates have declined due to advances in early detection and therapeutic strategies, the absolute number of cancer-related d…
  pubmed De Lella S, Esposito F, Matassa DS, Avolio R 2026 Sep 置信度 0.82
• CDK4/6-targeted therapy: From clinical inhibitors to emerging strategies to overcome resistance.
  The Cyclin-dependent kinase 4/6 (CDK4/6) complex orchestrates the critical G1-to-S phase transition by phosphorylating the Retinoblastoma protein (Rb), establishing it as a validated therapeutic target in oncology. The clinical deployment of ATP-competitive in…
  pubmed Sha W, Feng D, Yan Z, Chen Z 等 2026 Oct 置信度 0.82
• The natural isoflavone puerarin mitigates cerebral ischemia-reperfusion injury by directly targeting CaMKⅡδ to block DLG4-Ser654 phosphorylation.
  Synaptic collapse drives severe neurological deficits following cerebral ischemia-reperfusion (I/R) injury. Puerarin, a bioactive isoflavone from Pueraria lobata, exhibits neuroprotective properties, yet the precise kinase-substrate networks orchestrating its …
  pubmed Qian H, Guo S, Tao K, Dai S 等 2026 Sep 置信度 0.82
• LaeA Orchestrates Iron-Heme Supply and P450 Catalytic Efficiency for Enhanced Echinocandin B Biosynthesis in Aspergillus nidulans.
  Echinocandin B (ECB), a fungal non-ribosomal lipopeptide, serves as the exclusive natural precursor of the front-line antifungal anidulafungin. Despite its clinical importance, ECB production remains suboptimal due to incomplete understanding of its biosynthes…
  pubmed Yang X, Gao J, Shen D, Zhang Y 等 2026 Jul 置信度 0.82
• Agentic Discovery of Non-Canonical Antimicrobial Peptides with AMPGAN v3.
  Antimicrobial resistance causes to over a million deaths annually. Antimicrobial peptides (AMPs) are a promising solution, but generative AMP models are not yet ready to design peptides with non-natural amino acids and/or chemical modifications, which are esse…
  pubmed Jung JH, Zhang X, Song S, Sayedahmed M 等 2026 Jun 15 置信度 0.82
• Recombinant bone morphogenetic protein-2 attenuates colorectal cancer progression by orchestrating Hippo pathway activation, Yes-associated protein inhibition, and epithelial-mesenchymal transition suppression.
  Bone morphogenetic protein-2 (BMP-2) regulates cell differentiation and proliferation. However, its role in colorectal cancer (CRC) remains debatable owing to potential oncogenic effects. Here, we investigated the role of BMP-2 in modulating CRC progression, p…
  pubmed Wu Y, Lee NR, Liu YC, Kim MS 等 2026 Jul 1 置信度 0.82
• Biomarkers for COPD with Type 2 Inflammation.
  Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung disease traditionally characterized by neutrophilic inflammation. However, a distinct Type 2 (T2) inflammatory endotype is present in 20-40% of patients. This review examines the pathophysiol…
  pubmed Pathak C, Cox J, Suri R, Akuthota P 2026 Jun 27 置信度 0.82
• Orchestrator multi-agent clinical decision support system for secondary headache diagnosis in primary care.
  Secondary headaches require urgent recognition due to potentially devastating consequences if untreated. Despite established clinical "red flag" criteria, identifying patients needing immediate evaluation remains challenging in primary care. This study develop…
  pubmed Wu X, Zhang H, Garduno-Rapp NE, Rousseau JF 等 2026 Jun 27 置信度 0.82
• Atractylodes macrocephala polysaccharide orchestrates anti-tumor immunity via a dual-network mechanism targeting the gut microbiota and spleen.
  Colorectal cancer (CRC) is a common global malignancy, and its advanced stage is closely linked to a gut microbiota-metabolism-immunity vicious cycle requiring early intervention. In this study, anti-CRC effects of PAMK in CT26 tumor-bearing mice were explored…
  pubmed Shuai Y, Xing J, Liu X, Song Z 等 2026 Jun 26 置信度 0.82
• DNA origami as a biomaterials platform for programming ligand-receptor interactions and cell fate.
  DNA origami has emerged as a versatile biomaterials platform enabling programmable control over the nanoscale spatial organization of ligands. Unlike conventional biomaterials platforms, which offer limited geometric precision, DNA origami allows systematic en…
  pubmed Xu X, Kong Y, Mei Z, Zhang X 等 2026 Jul 28 置信度 0.82
• EASE-6G: An Energy-Aware SDN Framework with Proactive Slicing and DL-Based Overhead Mitigation for Scalable IoT Networks.
  Sixth-generation (6G) networks are expected to enable a new level of connectivity, with peak data rates reaching 1 Tbps and latencies below 0.1 ms, especially in large-scale Internet of Things (IoT) environments. Despite these advantages, the rapid increase in…
  pubmed Albeladi M, Jambi K, Eassa FE, Khemakhem M 2026 Jun 17 置信度 0.82
• Myelin Repair as a Neuroprotective Strategy for Multiple Sclerosis: From Bench to Bedside.
  Multiple sclerosis (MS) is a neuro-inflammatory disease characterized by demyelination in the central nervous system (CNS). Although a substantial endogenous capacity for remyelination has been demonstrated, this process is frequently incomplete and exhibits m…
  pubmed Battah T, Mastorodemos V, Struecker E, Mitsikostas DD 等 2026 Jun 18 置信度 0.82
• From Integrated Care to Learning Systems.
  Integrated care is increasingly shaped by digital infrastructures, data governance, and AI-enabled analytics, yet the relevant literature remains fragmented across health-services research, digital health, and machine learning. This article reports a scoping r…
  pubmed Tsitiridis A, Perakis K, Antoniades A, Manias G 2026 Jun 8 置信度 0.82
• Molecular Effects of Parkia speciosa Hassk. Empty Pod Extract in Colon Cancer: A Transcriptomic and Proteomic Perspective.
  This study elucidates the multi-targeted antineoplastic mechanisms of Parkia speciosa empty pod extract (PSET) against HCT-116 and HT-29 colorectal cancer (CRC) cells through integrated transcriptomic and proteomic analyses. Phytochemical profiling indicates t…
  pubmed Chaiwichien A, Osotprasit S, Samrit T, Smith SJ 等 2026 Jun 21 置信度 0.82
• Cellular Senescence and the SASP in HFpEF: Pathogenic Mechanisms and Therapeutic Targeting.
  Heart failure with preserved ejection fraction (HFpEF) represents a complex syndrome strongly associated with aging, characterized by diastolic dysfunction, myocardial stiffness, and chronic low-grade inflammation. Cellular senescence and the ensuing senescenc…
  pubmed Zhu QC, Zheng Q, Zhang H, Tu Y 等 2026 Jun 10 置信度 0.82
• Artificial Intelligence, Cognitive Abundance, and the Multi-Layered Competence of Health Professionals.
  Artificial intelligence (AI) is transforming how health care professionals develop, maintain, and express competence across the span of their careers. Traditional continuing professional development has been shaped by a paradigm of what has been called cogniti…
  pubmed Pusic MV, Ten Cate O 2026 Jun 26 置信度 0.82
• Orchestrating Diabetic Wound Healing by a Sunlight-Activated AIEgen-Selenide Nanospray: From Infection Control to Tissue Regeneration.
  Diabetic wounds, particularly diabetic ulcers (DUs), are life-threatening complications driven by bacterial infection, persistent inflammation, oxidative stress, and a dysfunctional immune microenvironment. Addressing these interconnected barriers requires a t…
  pubmed Kayani A, Raza A, Zhou Q, Li C 等 2026 Jul 8 置信度 0.82
• New insights into the ACLY-mediated metabolic and epigenetic interplay in macrophages.
  Macrophages are plastic innate immune cells that polarize into pro-inflammatory M1 or anti-inflammatory M2 phenotypes in response to microenvironmental signals, with their dynamic balance governing inflammation resolution and tissue homeostasis. This polarizat…
  pubmed Yuan L, Wang T, Song Y, Guo P 等 2026 Dec 置信度 0.82
• Structure-Based Virtual Screening and Mechanistic Characterization of Methotrexate and Selinexor as Potent Anti-Melanogenic Agents via Multi-Pathway Suppression of MITF.
  Tyrosinase is a pivotal therapeutic target for hyperpigmentation disorders, yet current inhibitors frequently exhibit limited potency and suboptimal safety. Here, we employed structure-based virtual screening of an FDA-approved drug library against a refined h…
  pubmed Zhang Z, Li H, Shi Z, Bai X 等 2026 Jun 11 置信度 0.82
• Small-molecule modulation of β-arrestins.
  β-Arrestins are multifunctional regulators of G-protein-coupled receptor (GPCR) signalling and orchestrate diverse downstream signalling events and physiological responses across the GPCR superfamily 1-3 . Although GPCR pharmacology has advanced to targe…
  pubmed Kahsai AW, Pakharukova N, Kwon HY, Shah KS 等 2026 Jun 24 置信度 0.82
• A NIR assisted composite scaffold incorporating CuHP and melatonin for enhanced anti-infection and bone regeneration in an acute rat model of infected bone defect.
  The clinical failure of infected bone repair is primarily due to the inability of conventional scaffolds to simultaneously eradicate resilient biofilms and orchestrate the subsequent bone regeneration within the hostile inflammatory microenvironment. In this s…
  pubmed Zhou L, He S, Gu J, Liu Y 等 2026 Jul 28 置信度 0.82
• Transcriptomic insights into the biocontrol mechanism of Trichoderma spp. against Fusarium wilt in melon.
  Fusarium wilt (FW), caused by Fusarium oxysporum f. sp. melonis (FOM), is a devastating disease severely impacting global melon (Cucumis melo L.) production. Biocontrol agents such as Trichoderma species, offer a sustainable alternative to chemical fungicides,…
  pubmed Aci MM, Tsalgatidou PC, Krommydas K, Boutsika A 等 2026 Jun 22 置信度 0.82
• Exploring the genetic landscape of ciprofloxacin-induced DNA supercompaction in Escherichia coli.
  DNA-damaging antibiotics like ciprofloxacin (CIP) induce extensive double-strand breaks in Escherichia coli, triggering both the SOS response and rapid DNA supercompaction. To uncover genes involved in the latter process beyond the previously identified k…
  pubmed Vikedal K, Berges N, Riisnæs IMM, Ræder SB 等 2026 Jun 22 置信度 0.82
• Beyond resorption: targeting osteoclast fusion and polarization to restore balanced bone remodeling.
  The prevalence of osteoporosis is increasing worldwide as populations age, creating a growing clinical burden of fragility fractures and highlighting limitations of current antiresorptive therapies. Conventional agents such as bisphosphonates and denosumab eff…
  pubmed Uehara S, Nakamura M, Kobayashi Y, Udagawa N 2026 置信度 0.82
• Insights in Food Allergy from DCs: The Influence and Mechanism of Diet Components with Antiallergic Properties.
  Food allergy (FA), defined as abnormal immunological response to certain food proteins, is a serious issue in food safety and public health. Dendritic cells (DCs) orchestrate tolerance or allergic reactions to food proteins. Accumulating researches show that d…
  pubmed Li L, Chen S, Zhao Y, Wei T 等 2026 Jul 1 置信度 0.82
• ROS-NRF2 axis coordinates concentration-graded differentiation-to-PANoptosis switching in a phthalide combination therapy for acute myeloid leukemia.
  In the context of multimodal therapeutic strategies for acute myeloid leukemia (AML), the coordinated regulation of cell death and differentiation pathways has emerged as a groundbreaking research direction.
  pubmed Luo M, Xia M, Chen Z, Wang Q 等 2026 Sep 置信度 0.82
• Cancer-associated fibroblasts as a target in head and neck squamous cell carcinoma: bridging mechanisms to therapy with drugs, adjuvants, and nanotechnology.
  The tumor microenvironment (TME) in head and neck squamous cell carcinoma (HNSCC) comprises a heterogeneous cellular landscape in which cancer cells, stromal cells, immune cells, and their secreted mediators collectively sustain a dynamic ecosystem. Cancer-ass…
  pubmed Asiri M, Zabebaha H, Hussein UA, Adel Z 等 2026 Jun 20 置信度 0.82
• Extruded biodegradable Zn-5Cu alloys with integrated osteoimmunomodulatory, antibacterial, and anti-osteolytic properties for patellar fracture suture repair.
  Zn-based biodegradable alloys hold promise for fracture suture-line applications, but are often limited by insufficient mechanical performance. In this study, alloying and extrusion were employed to regulate the microstructure of Zn-5Cu alloys, thereby synergi…
  pubmed Lin X, Lin Z, Wu H, Pan G 等 2026 Aug 置信度 0.82
• A bilayer polyurethane scaffold integrating degradation-dependent therapeutic release with directional exudate transport for diabetic wound healing.
  Diabetic wound management is compromised by infection, oxidative stress, and viscous exudates that dilute therapeutic agents. We report a spatially organized bilayer polyurethane scaffold designed to address these barriers. The scaffold integrates: (i) a hydro…
  pubmed Gao N, Zhang H, Gong Q, Wang J 等 2026 Nov 置信度 0.82
• Molecular regulation of PGC-1α: from protein-protein interactions and post-translational modifications to pharmacological modulation.
  Peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) is a master transcriptional coactivator responsible for regulating cellular energy metabolism and mitochondrial biogenesis across high-energy tissues such as the heart, skelet…
  pubmed Rios WQ, Silva CM, Ferreira R, Gomes JRB 2026 Jun 19 置信度 0.82
• OpenAI single-agent LLM architecture reduces computational overhead relative to multi-agent orchestration in a simulated mars rover decision-support benchmark.
  Mars rover missions require decision-support systems that can interpret terrain, telemetry, environmental conditions, and mission objectives under delayed communication with Earth. This study evaluates whether multi-agent orchestration improves simulated Mars …
  europepmc Dan Sanabria 2026 置信度 0.80
• Supporting adaptive Web-service orchestration with an agent conversation framework
  Service-oriented architecture is emerging as a compelling paradigm for developing Web-based software applications. In this style, the functional components of the system are implemented in various programming languages as network-accessible "services" declarat…
  crossref W. Blanchet, E. Stroulia, R. Elio 2005-11-15T15:48:27Z 置信度 0.70
• AI-Agent–Based Reliability Orchestration for Cloud–Fog Systems
  Cloud-fog systems are progressively supporting mission-critical and sensitive to latency applications, but the question of reliability when presented to dynamic workloads and heterogeneous resources, as well as the in-uits clouds, is still a key concern.
  crossref 2026-02-27T03:44:31Z 置信度 0.70
• Synergy: A Next-Generation General-Purpose Agent for Open Agentic Web
  AI agents are rapidly expanding in both capability and population: they now write code, operate computers across platforms, manage cloud infrastructure, and make purchasing decisions, while open-source frameworks such as OpenClaw are putting personal agents in…
  arxiv Xiaohang Nie, Zihan Guo, Kezhuo Yang, Zhichong Zheng 等 2026-03-30T13:35:37Z 置信度 0.78 cs.CYcs.MA
• SAT-Edge-Agent: Hardware-in-the-Loop Edge-Agent Orchestration for Onboard Satellite Intelligence
  Onboard satellite intelligence requires a task layer that translates mission intent into local tool calls, exposes execution state, and returns machine-consumable artifacts under communication and power constraints. We present SAT-Edge-Agent, a hardware-in-the…
  arxiv Longji He, Jeto Xu 2026-08-04T14:25:27Z 置信度 0.78 cs.AI
• RISCBench: Benchmarking RISC-V Orchestration Efficiency in FPGA and FPGA-Like Computing Engines
  Heterogeneous systems increasingly rely on RISC-V cores as orchestration engines to manage data movement, synchronization, and scheduling across accelerators and reconfigurable fabrics. Conventional performance metrics, such as FLOPs, TOPS/W, or energy per ope…
  arxiv Dave Ojika, Projjal Gupta, Preethi Budi, Herman Lam 等 2025-12-27T22:24:59Z 置信度 0.78 cs.AR
• Prompt Compression in Production Task Orchestration: A Pre-Registered Randomized Trial
  The economics of prompt compression depend not only on reducing input tokens but on how compression changes output length, which is typically priced several times higher. We evaluate this in a pre-registered six-arm randomized controlled trial of prompt compre…
  arxiv Warren Johnson, Charles Lee 2026-03-06T21:47:34Z 置信度 0.78 cs.CL
• Agentic Social Affordance Framework (ASAF): Agent Identity Design as a Collaboration Interface in Multi-Agent Systems
  As AI systems evolve from single agents to multi-agent architectures, a critical design dimension has been overlooked: how the social identity of individual agents shapes human behavior within the collaboration. This paper introduces the Agentic Social Afforda…
  arxiv Meng-Han Lee 2026-04-19T13:52:36Z 置信度 0.78 cs.HCcs.AI
• Design and Implementation of Agentic Orchestrations and Orchestration of Agents
  Agentic Business Process Management has gained momentum recently. The prospect is that the autonomy of AI agents, i.e., predominantly LLM-based agents, can be balanced with a certain level of robustness, tractability, and traceability through a combination wit…
  arxiv Stefanie Rinderle-Ma, Juergen Mangler, Johannes Loebbecke, Dominik Voigt 等 2026-06-30T11:31:49Z 置信度 0.78 cs.AI
• Agentic AI with Orchestrator-Agent Trust: A Modular Visual Classification Framework with Trust-Aware Orchestration and RAG-Based Reasoning
  Modern Artificial Intelligence (AI) increasingly relies on multi-agent architectures that blend visual and language understanding. Yet, a pressing challenge remains: How can we trust these agents especially in zero-shot settings with no fine-tuning? We introdu…
  arxiv Konstantinos I. Roumeliotis, Ranjan Sapkota, Manoj Karkee, Nikolaos D. Tselikas 2025-07-09T16:39:29Z 置信度 0.78 cs.AIcs.CL
• Orchestral AI: A Framework for Agent Orchestration
  The rapid proliferation of LLM agent frameworks has forced developers to choose between vendor lock-in through provider-specific SDKs and complex multi-package ecosystems that obscure control flow and hinder reproducibility. Integrating tool calling across mul…
  arxiv Alexander Roman, Jacob Roman 2026-01-05T22:02:11Z 置信度 0.78 cs.AIastro-ph.IMhep-ph
• Orchestra-o1: Omnimodal Agent Orchestration
  The recent success of agent swarms has shifted the paradigm of large language model (LLM)-based agents from single-agent workflows to multi-agent systems, highlighting the importance of agent orchestration for task decomposition and collaboration. However, exi…
  arxiv Fan Zhang, Vireo Zhang, Shengju Qian, Haoxuan Li 等 2026-06-10T04:50:35Z 置信度 0.78 cs.AIcs.CLcs.CV
• Timed Orchestration for Component-based Systems
  Individual machines in flexible production lines explicitly expose capabilities at their interfaces by means of parametric skills. Given such a set of configurable machines, a line integrator is faced with the problem of finding and tuning parameters for each …
  arxiv Chih-Hong Cheng, Lacramioara Astefanoaei, Harald Ruess, Souha Ben Rayana 等 2015-04-21T17:14:37Z 置信度 0.78 cs.FLcs.LOcs.SC
• Experience as a Compass: Multi-agent RAG with Evolving Orchestration and Agent Prompts
  Multi-agent Retrieval-Augmented Generation (RAG), wherein each agent takes on a specific role, supports hard queries that require multiple steps and sources, or complex reasoning. Existing approaches, however, rely on static agent behaviors and fixed orchestra…
  arxiv Sha Li, Naren Ramakrishnan 2026-04-01T13:45:52Z 置信度 0.78 cs.AI
• Reward Modeling for Multi-Agent Orchestration
  Multi-Agent Systems (MAS) built on Large Language Models (LLMs) require effective orchestration to coordinate specialized agents, yet training such orchestrators is hindered by limited supervision and high computational cost. We propose Orchestration Reward Mo…
  arxiv King Yeung Tsang, Zihao Zhao, Vishal Venkataramani, Haizhou Shi 等 2026-06-11T17:16:24Z 置信度 0.78 cs.AIcs.CLcs.LGcs.MA
• A Methodology to Engineer and Validate Dynamic Multi-level Multi-agent Based Simulations
  This article proposes a methodology to model and simulate complex systems, based on IRM4MLS, a generic agent-based meta-model able to deal with multi-level systems. This methodology permits the engineering of dynamic multi-level agent-based models, to represen…
  arxiv Jean-Baptiste Soyez, Gildas Morvan, Daniel Dupont, Rochdi Merzouki 2013-11-20T15:44:26Z 置信度 0.78 cs.MA
• Empirical Comparison of Agent Communication Protocols for Task Orchestration
  Context. The problem of comparative evaluation of communication protocols for task orchestration by large language model (LLM) agents is considered. The object of study is the process of interaction between LLM agents and external tools, as well as between aut…
  arxiv Ivan Dobrovolskyi 2026-03-24T05:50:58Z 置信度 0.78 cs.AI
• Next-Generation Event-Driven Architectures: Performance, Scalability, and Intelligent Orchestration Across Messaging Frameworks
  Modern distributed systems demand low-latency, fault-tolerant event processing that exceeds traditional messaging architecture limits. While frameworks including Apache Kafka, RabbitMQ, Apache Pulsar, NATS JetStream, and serverless event buses have matured sig…
  arxiv Jahidul Arafat, Fariha Tasmin, Sanjaya Poudel 2025-10-06T00:25:22Z 置信度 0.78 cs.DCcs.PF
• When Should We Orchestrate Multiple Agents?
  Strategies for orchestrating the interactions between multiple agents, both human and artificial, can wildly overestimate performance and underestimate the cost of orchestration. We design a framework to orchestrate agents under realistic conditions, such as i…
  arxiv Umang Bhatt, Sanyam Kapoor, Mihir Upadhyay, Ilia Sucholutsky 等 2025-03-17T14:26:07Z 置信度 0.78 cs.MAcs.CYcs.LG
• Knowledge Base-Aware Orchestration: A Dynamic, Privacy-Preserving Method for Multi-Agent Systems
  Multi-agent systems (MAS) are increasingly tasked with solving complex, knowledge-intensive problems where effective agent orchestration is critical. Conventional orchestration methods rely on static agent descriptions, which often become outdated or incomplet…
  arxiv Danilo Trombino, Vincenzo Pecorella, Alessandro de Giulii, Davide Tresoldi 2025-09-23T21:46:38Z 置信度 0.78 cs.MAcs.AI
• Multi-Agent Coordination Adaptation via Structure-Guided Orchestration
  As large language model (LLM)-based multi-agent systems scale to handle increasingly complex tasks, balancing structural stability and dynamic adaptability becomes increasingly challenging. Existing systems typically adopt either structure-centric methods, com…
  arxiv Haoran Li, Shulun Chen, Shaoyuan Sun, Hanchen Wang 2026-05-25T11:59:58Z 置信度 0.78 cs.MAcs.AI
• Augmenting the action space with conventions to improve multi-agent cooperation in Hanabi
  The card game Hanabi is considered a strong medium for the testing and development of multi-agent reinforcement learning (MARL) algorithms, due to its cooperative nature, partial observability, limited communication and remarkable complexity. Previous research…
  arxiv F. Bredell, H. A. Engelbrecht, J. C. Schoeman 2024-12-09T09:34:40Z 置信度 0.78 cs.MAcs.AIcs.LG
• Context Kubernetes: Declarative Orchestration of Enterprise Knowledge for Agentic AI Systems
  We introduce Context Kubernetes, an architecture for orchestrating enterprise knowledge in agentic AI systems, with a prototype implementation and eight experiments. The core observation is that delivering the right knowledge, to the right agent, with the righ…
  arxiv Charafeddine Mouzouni 2026-04-13T15:35:55Z 置信度 0.78 cs.AIcs.SE
• From Model-Based Screening to Data-Driven Surrogates: A Multi-Stage Workflow for Exploring Stochastic Agent-Based Models
  Systematic exploration of Agent-Based Models (ABMs) is challenged by the curse of dimensionality and their inherent stochasticity. We present a multi-stage pipeline integrating the systematic design of experiments with machine learning surrogates. Using a pred…
  arxiv Paul Saves, Matthieu Mastio, Nicolas Verstaevel, Benoit Gaudou 2026-04-03T15:32:49Z 置信度 0.78 cs.LGcs.AI
• In-Context Prompting Obsoletes Agent Orchestration for Procedural Tasks
  Agent orchestration frameworks -- LangGraph, CrewAI, Google ADK, OpenAI Agents SDK, and others -- place an external orchestrator above the LLM, tracking state and injecting routing instructions at every turn. We present a controlled comparison showing that for…
  arxiv Simon Dennis, Michael Diamond, Rivaan Patil, Kevin Shabahang 等 2026-04-30T14:07:37Z 置信度 0.78 cs.AIcs.LG
• Agents-K1: Towards Agent-native Knowledge Orchestration
  Current LLM-based research agents have advanced through agent orchestration, yet largely overlook scientific knowledge orchestration. Existing works often reduce papers to abstracts, surface mentions, and flat \texttt{cites} edges, omitting key entities, claim…
  arxiv Zongsheng Cao, Bihao Zhan, Jinxin Shi, Jiong Wang 等 2026-06-11T17:58:35Z 置信度 0.78 cs.AI
• Utility-Guided Agent Orchestration for Efficient LLM Tool Use
  Tool-using large language model (LLM) agents often face a fundamental tension between answer quality and execution cost. Fixed workflows are stable but inflexible, while free-form multi-step reasoning methods such as ReAct may improve task performance at the e…
  arxiv Boyan Liu, Gongming Zhao, Hongli Xu 2026-03-20T12:29:12Z 置信度 0.78 cs.AI
• Neural Orchestration for Multi-Agent Systems: A Deep Learning Framework for Optimal Agent Selection in Multi-Domain Task Environments
  Multi-agent systems (MAS) are foundational in simulating complex real-world scenarios involving autonomous, interacting entities. However, traditional MAS architectures often suffer from rigid coordination mechanisms and difficulty adapting to dynamic tasks. W…
  arxiv Kushagra Agrawal, Nisharg Nargund 2025-05-03T02:58:25Z 置信度 0.78 cs.MAcs.AIcs.NE
• Agent Banana: High-Fidelity Image Editing with Agentic Thinking and Tooling
  We study instruction-based image editing under professional workflows and identify three persistent challenges: (i) editors often over-edit, modifying content beyond the user's intent; (ii) existing models are largely single-turn, while multi-turn edits can al…
  arxiv Ruijie Ye, Jiayi Zhang, Zhuoxin Liu, Zihao Zhu 等 2026-02-09T18:59:18Z 置信度 0.78 cs.CV
• PerspectiveGap: A Benchmark for Multi-Agent Orchestration Prompting
  Real-world LLM applications are moving beyond single-agent workflows toward orchestrated multi-agent systems, yet current models still struggle to determine what each sub-agent needs to know. To measure this, we introduce PerspectiveGap, a benchmark for evalua…
  arxiv Youran Sun, Xingyu Ren, Kejia Zhang, Xinpeng Liu 等 2026-06-07T23:26:12Z 置信度 0.78 cs.CLcs.MA
• Agentic Lybic: Multi-Agent Execution System with Tiered Reasoning and Orchestration
  Autonomous agents for desktop automation struggle with complex multi-step tasks due to poor coordination and inadequate quality control. We introduce Agentic Lybic, a novel multi-agent system where the entire architecture operates as a finite-state machine (FS…
  arxiv Liangxuan Guo, Bin Zhu, Qingqian Tao, Kangning Liu 等 2025-09-14T03:22:27Z 置信度 0.78 cs.AIcs.HCcs.MA
• A Declarative Language for Building And Orchestrating LLM-Powered Agent Workflows
  Building deployment-ready LLM agents requires complex orchestration of tools, data sources, and control flow logic, yet existing systems tightly couple agent logic to specific programming languages and deployment models. We present a declarative system that se…
  arxiv Ivan Daunis 2025-12-22T05:03:37Z 置信度 0.78 cs.SEcs.AIcs.PL