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• 3D Fractal Analysis of Gd-EOB-DTPA-MRI for Vessels Encapsulating Tumor Clusters Prediction in Hepatocellular Carcinoma.
  This study aims to evaluate the potential role of 3-dimensional (3D) fractal analysis derived from Gd-EOB-DTPA-MRI in predicting vessels encapsulating tumor clusters (VETC) pattern in patients with hepatocellular carcinoma (HCC). This retrospective study inclu…
  europepmc 2026 置信度 0.80
• Lumican deficiency dysregulates trophoblast function via PI3K/AKT and P53 signaling in preeclampsia.
  Lumican, an extracellular matrix (ECM) component highly expressed in placenta, is implicated in preeclampsia (PE) pathogenesis, though its precise mechanisms in trophoblast function and PE development remain unclear. Transcriptomic analysis of a PE rat model i…
  europepmc 2026 置信度 0.80
• Comparative study of different methods for bathymetric mapping based on multi-source remote sensing data.
  Satellite-derived bathymetry (SDB) technology for mapping shallow water around islands and reefs plays a crucial role in the management of coastal zone resources. The accuracy of SDB depends strongly on the selection of satellite remote sensing data and bathym…
  europepmc 2026 置信度 0.80
• The spatiotemporal distribution and multi-scenarios for land use carbon metabolism: simulation and carbon reduction from the production-living-ecological space perspective.
  A comprehensive understanding of land use carbon metabolism characteristics from the production-living-ecological space (PLES) perspective is crucial for formulating carbon reduction strategies. As the core economic zone of northern China, the Beijing-Tianjin-…
  europepmc 2026 置信度 0.80
• A Pressure Difference-Based Strategy for Blood Oxygen Control in Membrane Oxygenators: Reduced Modeling, Computational Simulation, and Exploratory In Vivo Evaluation.
  Purpose This study investigated whether blood oxygenation in a membrane oxygenator can be regulated by modulating the gas-blood pressure difference. Methods This study combined theoretical analysis, reduced computational simulation, and exploratory in vivo ani…
  europepmc 2026 置信度 0.80
• Video summarization based on multi-scale feature fusion.
  Video summarization aims to identify the important segments of a video and form a concise representation, enabling users to quickly grasp the core information. Existing graph-based video summarization methods suffer from insufficient modeling of multi-scale fe…
  europepmc 2026 置信度 0.80
• A comparative and exploratory analysis of computational methods for TCR structural prediction and antigen-specific TCR discovery.
  Reliable structural prediction of T-cell receptors (TCRs) is essential for dissecting antigen recognition and accelerating TCR-based therapeutic development, yet the performance of emerging computational structure prediction models for this task requires furth…
  europepmc 2026 置信度 0.80
• Identifying a Csmd3<sup>+</sup> Microglial Subpopulation that Drives Cold-to-Hot Transition and Immune-Cure in Glioblastoma.
  Glioblastoma (GBM) is immunologically cold and responds poorly to immune-based therapies owing to its highly heterogeneous and immunosuppressive tumor microenvironment (TME). However, strategies to achieve a cold-to-hot transition remain elusive, and suitable …
  europepmc 2026 置信度 0.80
• Historical, taxonomic, and cultural patterns in scientific naming across Animalia.
  Animal naming is fundamental to biological classification and scientific communication. Beyond their taxonomic function, scientific names may also reflect historical and cultural contexts. Owing to this dual role, species names have recently attracted increasi…
  europepmc 2026 置信度 0.80
• Assessing disaster resilience in mountain villages using an improved DPSIR-A framework and multi-model machine learning.
  Amid the dual challenges of global climate change and frequent geological hazards, evaluating the disaster resilience of mountainous villages is crucial for sustainable regional development. This study proposes an integrated resilience assessment framework spe…
  europepmc 2026 置信度 0.80
• Risk of Inflammatory Bowel Disease Following Hospital-Treated Infections and Modulatory Role of Host Genetics to Support a Multi-Hit Pathogenesis Model.
  Infectious diseases can cause lasting immune disturbances, but whether they contribute to later inflammatory bowel disease (IBD) is unclear. Hospital-treated infections may be especially informative because they reflect substantial immune challenge, yet their …
  europepmc 2026 置信度 0.80
• Cotton Leaf Spot Detection Based on an Improved YOLOv11n Model.
  In cotton disease detection, the complex farmland environment and the varying scales of disease spots, especially the presence of small-target disease spots, limit the detection accuracy of lightweight models. To address this issue, an improved YOLOv11n detect…
  europepmc 2026 置信度 0.80
• Comparative Study of Effects of Different Organic Acid Treatments on Preservation Quality of Two Bamboo Shoot Species Using PCA Comprehensive Evaluation and Quality Index Models.
  Bamboo shoots undergo rapid postharvest quality deterioration. To evaluate the effects of organic acid treatments on the quality preservation of green bamboo ( Dendrocalamopsis oldhami ) shoots (GBSs) and lei bamboo ( Phyllostachys praecox f. preveynalis ) sho…
  europepmc 2026 置信度 0.80
• R4ST: a reference-guided graph-generative model for robust reconstruction of spatial transcriptomic profiles.
  Motivation The trade-off between spatial granularity and transcriptome coverage in current spatial transcriptomics (ST) technologies results in sparse and incomplete expression profiles. Meanwhile, the rich local and global spatial topology inherent in spatial…
  europepmc 2026 置信度 0.80
• Evaluation of Summer Maize Water and Nitrogen Management Strategies Across Different Hydrological Years Using the DSSAT Model.
  Summer maize ( Zea mays L.) production on the North China Plain is highly dependent on variable seasonal rainfall, which increases the likelihood that inappropriate water and nitrogen allocation will cause yield fluctuations and ecological and environmental ri…
  europepmc 2026 置信度 0.80
• Preclinical Evaluation of 177Lu-Labeled Anti-CLDN18.2 VHH-Fc for Radioimmunotherapy in Gastric Cancer.
  Purpose Claudin18.2 (CLDN18.2) has emerged as a significant therapeutic target for advanced gastric cancer. In this study, we aimed to develop a 177Lu-radiolabeled anti-CLDN18.2 VHH-Fc (SN-1A01) for radioimmunotherapy in gastric cancer (GC) tumor-bearing model…
  europepmc 2026 置信度 0.80
• Predicting global distribution of Caryopteris under climate change using an optimized MaxEnt model: insights into ecological adaptation and conservation.
  Climate change is reshaping plant species distributions, posing challenges for drought-adapted taxa with restricted native ranges. This study employed an optimized MaxEnt ecological niche model, using GBIF occurrence records and a suite of bioclimatic and UV-B…
  europepmc 2026 置信度 0.80
• GT-Mamba: a Topology-Aware Graph-State space model for robust and interpretable epigenetic age prediction.
  Motivation Current epigenetic clocks face a trade-off between predictive accuracy and biological interpretability, often relying on dataset-specific correction to generalize across cohorts. We propose GT-Mamba, a novel architecture that integrates a Structure-…
  europepmc 2026 置信度 0.80
• Ultrahigh Stretchability of Organogel Networks: Fiber Evolution and the "Fishing Net Model".
  Stretchable gels have attracted tremendous attention in the fields of flexible electronics and wearable devices. However, the lack of systematic observations on microstructural evolution during ultrahigh stretching (above 400%) restricts the rational design of…
  europepmc 2026 置信度 0.80
• Adsorption characteristics and mechanism of modified biochar for cadmium mediated by microplastics.
  In this study, iron-modified biochar (IMB) was used as an adsorbent, and PLA microplastics of different particle sizes were selected. The adsorption characteristics and mechanisms of the heavy metal Cd were systematically investigated in systems where PLA and …
  europepmc 2026 置信度 0.80
• Associations of sociodemographic and behavioral factors with frailty transition patterns: a multi-state Markov analysis of the China Health and Retirement Longitudinal Study (CHARLS).
  Background Frailty state is dynamic and reversible, but there is a lack of clarity about the patterns of frailty transition and its influencing factors. This study aimed to investigate frailty transitions and the impact of sociodemographic and behavioral facto…
  europepmc 2026 置信度 0.80
• Individualized prediction of heroin cue-induced craving using task-based EEG functional connectivity.
  Cue-induced craving is a core driver of addiction and relapse, and its significant heterogeneity represents a major barrier to precision intervention. Currently, there remains a lack of objective, quantifiable, and individualized neurobiological biomarkers. He…
  europepmc 2026 置信度 0.80
• Investigation of Drug Responses in 3-D Tumor Spheroid Models Using Two-Photon Scanning Structured Illumination Super-Resolution Microscopy With Frequency-Specific Denoising Enhancement.
  Two-dimensional cell culture models have long been a cornerstone of biomedical research; however, they often fail to accurately replicate the in vivo environment. In recent years, three-dimensional (3D) cell cultures, particularly 3D spheroid models, have gain…
  europepmc 2026 置信度 0.80
• Coverage Probability Analysis and Relay Placement Optimization for Two-Hop LoRa Networks with Random Traffic Activation.
  In LoRa uplink communication, direct edge-node-to-gateway transmission is affected by path loss, thermal noise, small-scale fading, and intra-spreading-factor (intra-SF) and inter-spreading-factor (inter-SF) interference under random traffic activation. These …
  europepmc 2026 置信度 0.80
• GinkgoSense-Net: A method for characterization and real-time detection of ginkgo fruits in complex field environments.
  Automatic picking of ginkgo fruits is beneficial for prolonging their freshness and ensuring quality during storage. Accurate identification of ginkgo fruits is a critical prerequisite for enabling stable and reliable operation of the end-effector during the h…
  europepmc 2026 置信度 0.80
• Investigating Nonlinear Fatigue Damage Evolution of SBS-Modified Asphalt Mixtures with Physical Gel Structure.
  Styrene-butadiene-styrene (SBS) modifier can enhance the resistance of asphalt mixtures to load-induced deformation and fatigue cracking by constructing a three-dimensional physical gel network. However, a rigorous mechanical characterization of this mechanism…
  europepmc 2026 置信度 0.80
• Optimization of Enzymatic Hydrolysis Process for Tobacco stem via Response Surface Methodology and its Application in Reconstituted Tobacco leaf.
  To enhance lignocellulose degradation in tobacco stem fibers and improve the quality of reconstituted tobacco, this study optimized xylanase-mediated hydrolysis. Xylanase OKBK was identified as the most effective enzyme, producing a reducing sugar yield of 2.2…
  europepmc 2026 置信度 0.80
• Functionalized Biomimetic Scaffolds for Human-Derived Auditory Neural Circuit Construction.
  Damage to auditory circuits results in sensorineural hearing loss. However, the scarcity of human inner ear tissue significantly hinders the development of therapies to preserve auditory function, creating a critical need for reliable in vitro models. While hu…
  europepmc 2026 置信度 0.80
• An Interpretable Machine Learning Model for Predicting the Presence of Talaromycosis in HIV Patients Lacking Skin Lesions.
  Introduction The existing predictive models for talaromycosis in people living with HIV without skin lesions are limited by established risk factors and traditional statistical approaches. This study aims to develop an interpretable machine learning(ML) model …
  europepmc 2026 置信度 0.80
• Cellular plasticity of cancer: roles of biomolecular condensates and ecDNA.
  Cancer is characterized not only by malignant transformation driven by genomic alterations but also by remarkable cellular plasticity that enables adaptation to environmental and therapeutic stress. Cancer cell plasticity frequently involves extensive remodeli…
  europepmc 2026 置信度 0.80
• Development and validation of a multimodal machine learning prediction model for heart failure after acute myocardial infarction.
  Heart failure after acute myocardial infarction (post-MI HF) has become a major global health problem. Accurate risk prediction is essential for optimising management and preventing post-MI HF. However, existing models rely mainly on resting-state clinical exa…
  europepmc 2026 置信度 0.80
• CXCL9/SPP1-polarized tumor-associated macrophages exert dual roles in regulating anti-tumor immunity in lung adenocarcinoma.
  Background CS polarity, the mutually exclusive expression of CXCL9 and SPP1, is a key feature of tumor-associated macrophages (TAMs) in the lung adenocarcinoma (LUAD) microenvironment. The mechanisms and impact of CS polarity on tumor progression remain incomp…
  europepmc 2026 置信度 0.80
• RLAnOxPeptide: an integrated framework combining transformer and reinforcement learning for efficient antioxidant peptide prediction and innovative design.
  Motivation Bioactive peptides exhibit immense potential in pharmaceutical and food science domains, with antioxidant peptides (AOPs) garnering significant attention for their roles in scavenging free radicals. However, traditional discovery methods are ineffic…
  europepmc 2026 置信度 0.80
• Numerical investigation on the impact of solitary waves with variable incidence angles on offshore box-girder bridges.
  Solitary waves are a kind of long-wavelength, high-energy gravity waves that are caused by submarine movements and similar events. Their impact on offshore structures is a typical strongly nonlinear hydrodynamic process that is critical in coastal bridge desig…
  europepmc 2026 置信度 0.80
• Proteomic identification of NF-κB-related targets associated with the anti-inflammatory activity of Gomisin R in LPS-stimulated RAW264.7 cells.
  Background Kadsura longipedunculata Finet et Gagnep. belongs to the Kadsura Kaempf.exJuss. Vaccinium of the family Magnoliaceae. It mainly distributes in regions such as Guangxi, Sichuan, Fujian and Yunnan of China. Commonly used as traditional Chinese medicin…
  europepmc 2026 置信度 0.80
• Serum uric acid, gout, cardiometabolic diseases, and multimorbidity: a prospective cohort study using multi-state model.
  Multimorbidity, particularly cardiometabolic multimorbidity (CMM), is a growing global health challenge, defined by the co-occurrence of cardiometabolic diseases (CMDs) like type 2 diabetes, ischemic heart disease, and stroke. While serum uric acid (SUA) and g…
  europepmc 2026 置信度 0.80
• Correction to "Computational Insights into the N-Migration and Oxidative Rearrangement Involved in the <i>N</i>-Nitrosourea Formation Catalyzed by the Cupin Domain of Multidomain Metalloenzyme SznF.
  europepmc 2026 置信度 0.80
• On the nature of chemical short-range order evolution.
  Chemical short-range order (CSRO), the non-random local arrangement of atoms in solid solutions, strongly affects the phase stability and performance of medium- and high-entropy alloys (M/HEAs). Despite its importance, the fundamental nature of CSRO formation …
  europepmc 2026 置信度 0.80
• Rice Safety Risk Data Generation Model Based on Gated Feature Transformation and Adaptive Diffusion.
  Rice safety risk assessment relies on complete monitoring data. However, limited by the cost of laboratory testing, severe data scarcity is often encountered in practice, which greatly hinders the effective implementation of food safety evaluation. Focusing on…
  europepmc 2026 置信度 0.80
• A Pulsed Tumor Treating Fields Protocol to Improve Glioblastoma Therapy.
  Tumor Treating Fields (TTFields) utilize alternating fields (AC fields) within 100-300 kHz and electric field strengths above 1 V/,cm for glioblastoma (GBM) treatment. However, the electric field is often reduced to a relatively low value (below 1 V/cm) due to…
  europepmc 2026 置信度 0.80
• Construction of a faculty competency model for medical simulation education integrated with GenAI: a multi-method quantitative study based on the perspective of medical students.
  Background The rapid advancement of Generative Artificial Intelligence (GenAI) is reshaping the landscape of medical simulation education, necessitating the enhancement of faculty competencies to effectively integrate evolving knowledge systems with GenAI for …
  europepmc 2026 置信度 0.80
• An Ensemble Learning Approach to Graph Learning Based on Evolutionary Graph Neural Architecture Search.
  The graph neural networks (GNNs) have been successfully applied to non-Euclidean graph data mining tasks, attracting widespread attention. At present, to achieve promising performance, many researchers use neural architecture search (NAS) on GNNs to enhance ap…
  europepmc 2026 置信度 0.80
• Bridging the Gap between External and Internal Exposure: Challenges and a Machine Learning Approach Validated Using Benzene Ring-Containing Pollutants.
  Establishing quantitative linkages between external and internal exposures is essential for accurate exposure and health risk assessment, yet this goal remains hindered by multiple challenges. This Perspective systematically reviews major challenges limiting t…
  europepmc 2026 置信度 0.80
• Development and psychometric evaluation of a symptom assessment scale for adjuvant radiotherapy in breast cancer patients based on the symptom experience model.
  To develop and validate a symptom assessment scale for postoperative adjuvant radiotherapy in breast cancer patients based on the Symptom Experience Model, providing a basis for healthcare professionals to evaluate symptoms and formulate personalized symptom m…
  europepmc 2026 置信度 0.80
• Mechanistic investigation of Chai Gui Zexie Decoction in treating non-small cell lung cancer: an integrated metabolomics and network pharmacology approach.
  This study aimed to elucidate the therapeutic mechanisms of Chai Gui Zexie Decoction against non-small cell lung cancer (NSCLC) through an integrated approach combining metabolomics, network pharmacology, and experimental validation. A subcutaneous NSCLC metas…
  europepmc 2026 置信度 0.80
• Metabolic Profiling of Panax notoginseng Saponins in Rat Feces Under Colitis by UHPLC-QTOF-MS/MS.
  The biotransformation of Panax notoginseng saponins (PNS) is pertinent to the effect of colitis mediated by gut microbiota, which has variant microbes and diversities in inflammatory bowel diseases (IBDs). However, the metabolic profiles of PNS mediated by gut…
  europepmc 2026 置信度 0.80
• Wafer-Scale All-Silicon Self-Rectifying Memristor for Synaptic Response and Reservoir Computing.
  Silicon p-n junctions have remained an indispensable building block of electronics since their invention in the Shockley days. Likewise, an abrupt p-n junction has served as a foundational model in semiconductor textbooks. In this work, we report on an p-n jun…
  europepmc 2026 置信度 0.80
• Pharmacological effects of nebivolol on endothelial response in a preeclampsia in vitro model.
  Preeclampsia (PE) is a pregnancy-specific hypertensive disorder characterized by systemic endothelial dysfunction and a profound anti-angiogenic state driven by elevated soluble fms-like tyrosine kinase-1 (sFlt-1). While the third-generation β 1 -AR nebivolol …
  europepmc 2026 置信度 0.80
• Detection of coronary microvascular dysfunction based on machine learning algorithm with multidimensional temporal-spatial features from electrocardiogram.
  Objective. Coronary microvascular dysfunction (CMD) causes myocardial ischemia and is associated with adverse cardiovascular events. This study explored the value of multidimensional electrocardiogram (ECG) features in capturing pathological changes linked to …
  europepmc 2026 置信度 0.80
• Generalized graph foundation models as versatile data-driven digital twins for complex technological systems.
  Digital twins are comprised of computational models that mimic the 'as built' characteristics of devices, systems, and networks of systems whose performance in the real world warrants quantitative and critical assessment.The literature on constructing digital …
  europepmc 2026 置信度 0.80
• Enhanced crystal-melt segregation within dynamic mush systems links silicic cumulates with caldera-forming eruptions.
  Supported by the mush model, the origin of crystal-poor, high-silica rhyolitic magmas (≥ 75 SiO₂ wt.%) is commonly linked to melt extraction in shallow, crystalline mushes, yet their complementary cumulates remain elusive in the upper crust. Here we present th…
  europepmc 2026 置信度 0.80
• FC$^{2}$2: Fast Co-Clustering With Small-Scale Similarity Graph and Bipartite Graph Learning.
  Bipartite graph-based co-clustering is efficient in modeling cluster manifold structures. However, existing methods decouple bipartite graph construction from the learning of pseudo-labels for samples and anchors, often leading to suboptimal clustering perform…
  europepmc 2026 置信度 0.80
• Identification of a novel human gut microbes and microbial metabolites related genes signature for prognostic implication in head and neck squamous carcinomas.
  Background The gut microbiota acts as a critical driver influencing the pathogenesis, therapeutic response, and clinical outcomes across various cancer types. This study aimed to investigate the prognostic value of human gut microbes and microbial metabolites …
  europepmc 2026 置信度 0.80
• Fuzzy comprehensive evaluation of rock burst risk based on combined subjective and objective weighting.
  During deep coal mining, the rock mass is subjected to high in-situ stress and strong mining disturbances. Its mechanical properties are more sensitive than those of shallow rock mass, which can easily induce rock burst disasters, seriously restricting the saf…
  europepmc 2026 置信度 0.80
• The Expanded Biopsychosocial Model Elucidates the Association Between Pre-Pregnancy Overweight/Obesity and Delayed Lactogenesis II: A Prospective Cohort Study.
  Pre-pregnancy overweight or obesity delays the onset of lactogenesis II, posing an early barrier to achieving optimal infant nutrition and long-term health. However, the underlying pathophysiological mechanisms remain incompletely elucidated. This prospective …
  europepmc 2026 置信度 0.80
• Multimodal MRI-based nomogram integrating clinical-radiological, radiomic, and habitat features to discriminate solitary fibrous tumors from atypical meningiomas.
  This study aimed to develop and validate a fused model integrating clinical-radiological, radiomic, and habitat features from magnetic resonance imaging (MRI) for differentiating intracranial solitary fibrous tumors (ISFTs) from atypical meningiomas (ATMs). Th…
  europepmc 2026 置信度 0.80
• GATESynergy: Integrating Molecular Global-Local Aggregator and Hierarchical Gene-Gated Encoder for Drug Synergy Prediction.
  Combination drug therapy is an effective approach to combating drug resistance and enhancing therapeutic efficacy in complex diseases such as cancer. Nevertheless, discovering synergistic drug pairs remains difficult because of the enormous combinatorial possi…
  europepmc 2026 置信度 0.80
• USF1-mediated transcription of PARP1 contributes to sevoflurane-induced pyroptosis in perioperative neurocognitive disorders.
  Perioperative neurocognitive disorders (POCD) are a class of common complications of central nervous system after general anesthesia and surgery. Sevoflurane (SEV) is a widely used inhalation anesthetic in clinical practice, but the mechanism of SEV-induced ne…
  europepmc 2026 置信度 0.80
• Blurred and occluded target recognition in terahertz images based on improved YOLOv5.
  Terahertz (THz) imaging technology is widely used in applications such as security screening, radar detection, and biomedical applications. Nevertheless, due to the inherent limitations of imaging conditions, THz images often exhibit low contrast, blurred cont…
  europepmc 2026 置信度 0.80
• Rethinking bioinformatics expertise in the era of artificial intelligence.
  Artificial intelligence (AI) is often framed as replacing scientific expertise, especially in bioinformatics. We argue instead that AI is a powerful accelerant whose value depends on expert guidance in design, data curation, interpretation, and governance. Bec…
  europepmc 2026 置信度 0.80
• Preoperative prediction of lymphovascular and perineural invasion in locally advanced gastric cancer via CT habitat analysis and deep learning: A dual-center study.
  Purpose To develop and validate a combined model integrating CT-based habitat analysis and deep learning (DL) features for the preoperative prediction of lymphovascular and perineural invasion (LVI/PNI) in locally advanced gastric cancer (LAGC). Methods This d…
  europepmc 2026 置信度 0.80
• MitoClipSplice: a machine learning framework for resolving mitochondrial RNA cleavage sites from strand-specific RNA-seq soft-clips.
  Mitochondrial RNA processing directed by the transfer ribonucleic acid (tRNA) punctuation model is essential for function and linked to human diseases. Strand-specific RNA sequencing can capture cleavage intermediates as reads with soft-clipping (unmapped sequ…
  pubmed Yuan Q, Li Y, Xie F, Liu X 等 2026 Jul 3 置信度 0.82
• A Novel Extracorporeal Membrane Oxygenation System With Enhanced Hemocompatibility and Long-Term Stability.
  To optimize and evaluate the hydrodynamic performance and gas exchange efficiency of a newly developed centrifugal blood pump and membrane oxygenator for extracorporeal membrane oxygenation (ECMO) support, blood pump and oxygenator designs were optimized from …
  pubmed Wang H, Liu S, Jin Z, Wang Y 等 2026 Aug 6 置信度 0.82
• The potential regulatory relationship between hsa_circ_0000973 and MBOAT2 in hypertriglyceridemia with abnormal glucose metabolism.
  Hypertriglyceridemia (HTG) frequently occurs in population with abnormal glucose metabolism (AGM), exacerbating risk. In our preliminary researches, we have screened hsa_circ_0000973 and MBOAT2 as the possible regulatory elements of HTG in AGM patients. This s…
  pubmed Wang F, Yang Y, Li X, Xu Y 等 2026 Jul 28 置信度 0.82
• An Injectable Dual Bacterial-Trapping Nanozyme Composite Hydrogel for Synergistic Antibacterial/Anti-Inflammatory Therapy of Endophthalmitis.
  Bacterial endophthalmitis (BE) is characterized by severe intraocular bacterial infection and sustained inflammation. Current therapeutic efficacy is compromised by the passive diffusion-dominated drug release kinetics of conventional carriers, leading to inad…
  pubmed Fang G, Liu Y, Zhang G, Li S 等 2026 Aug 6 置信度 0.82
• Long-Term Blood Pressure Variability, Hippocampal Subfield Volume and Cognitive Decline: A Population-Based Prospective MRI Study.
  Long-term blood pressure variability (BPV) is associated with cognitive decline, yet the underlying mechanisms have not been fully elucidated.
  pubmed Li F, Chen J, Shi H, Yang L 等 2026 Aug 6 置信度 0.82
• Perceived Ageism and Subsequent Health and Well-Being in Older Adults: An Outcome-Wide Longitudinal Analysis From Japan.
  Perceived ageism may affect health in later life, but longitudinal associations across diverse outcomes, particularly cognitive and functional outcomes, remain unclear. We examined these associations among community-dwelling older adults in Japan.
  pubmed Kawaguchi K, Nakagomi A, Koga C, Kondo K 2026 Aug 6 置信度 0.82
• Implicit biases change more slowly in larger cities.
  Implicit biases remain a contributor to discrimination despite widespread endorsement of equality. Although there has been a large-scale reduction in sexuality, race, and skin tone biases in the past two decades, there is a current shortage of quantitative the…
  pubmed Stier AJ 2026 Aug 11 置信度 0.82
• Landscape Preferences and Leisure Constraints in Age-Friendly Community Parks.
  Community parks are public spaces frequently used by older adults for outdoor physical activity. This makes age-friendly renewal increasingly important in urban planning. However, the mechanisms through which landscape characteristics influence serious leisure…
  pubmed Li Y, Du C, Li B 2026 Aug 置信度 0.82
• Plasma Proteomic Profiles Predict Subsequent Obstructive Sleep Apnea Diagnosis in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease.
  Early detection of obstructive sleep apnea (OSA) in adults with metabolic dysfunction associated steatotic liver disease (MASLD) remains a clinical challenge. Plasma proteomics provides a non-invasive tool for identifying individuals at elevated risk prior to …
  pubmed Luo Y, Huang J, Chen R, Liu X 等 2026 Aug 15 置信度 0.82
• Prediction tools to prioritise hospitalised adult patients at risk of drug related problems: An umbrella review.
  Risk prediction tools assist pharmacists to identify and prioritise hospitalised patients at risk of drug-related problems (DRPs) requiring clinical review. This umbrella review identifies existing risk prediction tools, summarises their performance, and highl…
  pubmed Gutteridge DS, Babu D, Stasinopoulos J, Calder A 等 2026 Aug 置信度 0.82
• "I feel like a space where we all share our identity would be great": Carving pathways for future Latina researchers via youth participatory action research.
  Using the Roadmap for Centering Latinx Youth Voice in Developmental Science (Bañales, Pinetta, et al., 2023) and Positive Youth Development Model for Girls of Color (Clonan-Roy et al., 2016), we explored how youth participatory action research spaces can …
  pubmed Pinetta BJ, Cabrera SA, Bañales J 2026 Aug 6 置信度 0.82
• Model-Assisted Prioritization of Gelatin Methacryloyl (GelMA) Hydrogel Formulations for Three-Dimensional Cell Culture.
  Owing to highly tunable mechanics, gelatin methacryloyl (GelMA) hydrogels are widely exploited for three-dimensional (3D) cell culture, whereas limited experimental sampling restricts efficient formulation screening. In this work, we developed a BNN-based mode…
  pubmed Yin P, Wang X, Liu S, Huang Y 等 2026 Aug 5 置信度 0.82
• Tuning Pore Microenvironments in Covalent Organic Frameworks for Controlled Enzyme Loading and Release.
  Covalent Organic Frameworks (COFs) with tunable pore environments provide a versatile platform for enzyme delivery; however, the relationship between pore microenvironment and enzyme loading and release behavior remains insufficiently explored. Herein, we repo…
  pubmed Fan W, Phipps J, Tan K, AlShahrani T 等 2026 Aug 6 置信度 0.82
• Precise Early Diagnosis of Periodontal Disease via Microfluidic OECTs.
  Saliva-based point-of-care testing (POCT) is critical for the early diagnosis of periodontal disease. However, current wearable platforms, such as smart mouthguards, are predominantly limited to monitoring small metabolites (e.g., glucose) and cannot detect sp…
  pubmed Mai R, Zhou Y, Zhou J, Xie M 等 2026 Aug 6 置信度 0.82
• Boosting Cancer Immunotherapy by Integrating Cuproptosis and Mild Photothermal Therapy in a Biomimetic Nanoplatform.
  Breast cancer remains a global health challenge with limited therapeutic options for metastatic cases. Cuproptosis, a copper-dependent cell death pathway, offers a novel anticancer strategy that is currently constrained by the poor solubility of copper complex…
  pubmed Zeng Y, Hu J, Chen R, Chen H 等 2026 Aug 6 置信度 0.82
• Antibiotic loaded solid lipid nanoparticles target bacteria in a pyogenic spondylitis rat model.
  Pyogenic spondylitis is treated with high-dose antibiotics for at least six weeks. In this study, we aimed to develop a novel therapeutic agent that can enhance bacterial targeting. We used solid lipid nanoparticles (SLNs) containing the antibiotic ampicillin …
  pubmed Kim MJ, Han GH, Ko WK, Kim SJ 等 2026 Aug 6 置信度 0.82
• Radiation-resistant and desiccation-tolerant bacteria from the Chavara-Neendakara high background radiation area, india: phenotypic characterisation and genomic insights.
  Radiation-resistant microorganisms that survive high doses of ionising radiation serve as valuable models for understanding stress adaptation; however, the genomic determinants underlying extreme radiation tolerance in bacteria from natural environments with h…
  pubmed Thomas A, Mahajan M, Babu SS, Anoop G 等 2026 Aug 6 置信度 0.82
• Exosomal PKM2 from AML cells reprograms endothelial metabolism to promote angiogenesis and chemoresistance.
  In acute myeloid leukemia (AML), therapeutic resistance is intimately linked to vascular microenvironment remodeling; however, the initiating molecular determinants remain elusive. Here, we identified exosomal pyruvate kinase M2 (PKM2) as a pivotal mediator of…
  pubmed Wang X, You R, Fang W, Kang L 等 2026 Aug 6 置信度 0.82
• Endometriosis subtypes and risk of type 2 diabetes: the Advancing Research on Cardiovascular Health and Endometriosis Study (ARCHES) retrospective cohort study.
  Endometriosis is a heterogeneous inflammatory condition that may influence long-term metabolic health. Prior studies have reported largely null associations with type 2 diabetes, potentially missing subtype-specific and subgroup heterogeneity. We investigated …
  pubmed Fuzak Nunziato M, Yan B, Schliep KC, Farland LV 等 2026 Aug 6 置信度 0.82
• Kinetic profiles and efficiency disparities in biomethane production mediated by indigenous versus exogenous microbial consortia.
  Biomethane is a clean, renewable, and eco-friendly unconventional natural gas resource that has attracted widespread global attention. However, the differences in biomethane generation and the constraining factors under the drive of indigenous versus exogenous…
  pubmed Chen X, Bao Y, Wang X, Hu Y 等 2026 Aug 6 置信度 0.82
• Associations between dietary vitamin K1 and K2 intake and incident dementia: findings from the Danish Diet, Cancer, and Health cohort.
  Vitamin K is hypothesised to support vascular integrity and neuronal function through vitamin K-dependent proteins, yet epidemiological evidence for its role in dementia, particularly distinguishing vitamin K1 and K2, is limited. This aetiological study examin…
  pubmed Ghasemifard N, Sim M, Pokharel P, Li C 等 2026 Aug 6 置信度 0.82
• Role of the TLR4-NF-κB-FDX1 cuproptosis axis in mediating cognitive impairment associated with type 1 diabetes in children: an exploratory mechanistic study.
  This study explored how the TLR4-NF-κB-FDX1 cuproptosis axis contributes to type 1 diabetes (T1DM)-related cognitive impairment, seeking to uncover novel intervention targets. Key genes were screened from T1DM datasets via bioinformatics analysis. Primar…
  pubmed Wang J, Zhang LH, Meng XY, Kang YM 2026 Aug 6 置信度 0.82
• Aurantio-Obtusin Attenuates Aβ-Induced Cognitive Impairment and Synaptic Dysfunction by Suppressing Neuroinflammation in Mice.
  Alzheimer's disease (AD) features Aβ-driven neuroinflammation and synaptic dysfunction that converge on cognitive decline, underscoring the potential value of multi-target interventions. Aurantio-obtusin (AO), a bioactive anthraquinone from Cassia obtusi…
  pubmed Feng X, Yu W, Guo S, Ji Y 等 2026 Aug 6 置信度 0.82
• Adherence to a Chinese planetary health diet, environmental impacts, and all-cause mortality risk: a prospective cohort study from the China Health and Nutrition Survey.
  We aimed to develop a culturally specific Chinese Planetary Health Diet Score (CPHDS) and to evaluate its associations with environmental footprints and all-cause mortality.
  pubmed Lu J, Wang W, Peng T, Zhou Y 等 2026 Aug 6 置信度 0.82
• Ligand-Dependent Interface Dynamics of Rod-like Au25 Nanoclusters in Acidic and Electrochemical Media.
  Atomically precise gold nanoclusters have emerged as ideal model systems for studying structure-property relationships and revealing electrocatalytic reaction mechanisms. However, an atomic scale understanding of the dynamic stability and desorption behavior o…
  pubmed Sun F, Tang Q 2026 Aug 6 置信度 0.82
• Leveraging Multimodal Self-Consistency Reasoning in Coding Motivational Interviewing for Alcohol Use Reduction.
  Understanding client behaviors and predicting their outcomes require coding Motivational interviewing (MI) sessions with intensive labor costs and time consumptions of MI professionals. The advances in audio language models (ALMs) open promising opportunities …
  pubmed Han G, Murphy JG, Ladd BO, Huang X 等 2026 Aug 1 置信度 0.82
• Surgical Approaches for Peripheral Nerve Injury Models in Yucatan Pigs.
  Peripheral nerve injury (PNI) is a common component of combat extremity trauma, frequently associated with residual disability. Large animal models are critical for the study of PNI because of their anatomical and physiological similarities to human nerves. Th…
  pubmed Arave M, Gaviria M, Phan N, Miller B 等 2026 Aug 1 置信度 0.82
• Adsorbate-Induced Reversible Changes in Zeolite ZEO-5 Attributed to Its Triple-Four-Silicate-Rings.
  Extra-large pore zeolites exhibit structural features distinct from those of classical zeolites, with potential consequences in their use as adsorbents and catalysts. A low-framework-density zeolite, ZEO-5, was synthesized via interchain expansion, forming unp…
  pubmed Gao ZR, Aristizabal-González C, Prerna, Weng X 等 2026 Aug 6 置信度 0.82
• Biomimetic Synthesis of Multinuclear Metal-Oxo Bridges Under Mild Aqueous Conditions for Catalytic Cancer Therapy.
  In biological systems, enzymes achieve efficient catalysis by precisely assembling multinuclear metal-oxo bridges, such as Fe─O─Fe motifs, under physiological conditions. However, constructing such structures in synthetic systems, particularly un…
  pubmed Wang Z, Zhang X, Wang Y, Zheng Y 等 2026 Aug 6 置信度 0.82
• A Comprehensive Risk Assessment Framework for Groundwater Quality: Integrating Natural Background Levels, Threshold Values, and Machine Learning-Based Hydrochemical Facies Classification.
  Groundwater is a critical freshwater resource increasingly affected by anthropogenic activities. This study introduces an innovative and integrated framework for assessing the groundwater quality of the Qazvin aquifer, Iran, by combining iterative statistical …
  pubmed Amiri V, Li P, Torabi-Kaveh M 2026 Aug 置信度 0.82
• Ionizable Lipid-Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties.
  Lipid nanoparticles (LNPs) are a leading platform for nucleic acid delivery, yet their intrinsic adjuvanticity poses a significant materials design challenge for applications requiring immunological quiescence. Here, we report a modular engineering strategy th…
  pubmed Thatte AS, Nachod BE, Baena J, Muscat-Rivera J 等 2026 Aug 6 置信度 0.82
• Advances in Computational and Experimental Approaches to Chemical Short-Range Order Formation in Multi-Principal Element Alloys.
  Chemical short-range order (CSRO) in Multi-Principal Element Alloys (MPEAs) arises from non-random atomic arrangements within local coordination shells and plays a critical role in governing mechanical properties, diffusion kinetics, and phase stability. Captu…
  pubmed Asle Zaeem M, Liaw PK 2026 Aug 6 置信度 0.82
• Heterotypic interfacial tension between oncogenic and wild-type populations forms the mechanical basis of tissue-specific oncogenesis in epithelia.
  Why does the same oncogenic mutation drive tumor formation in some tissues but not in others? While cancer driver mutations are well documented, their tissue-specific effects remain largely attributed to genetic factors, leaving the biophysical aspects underex…
  pubmed Datta A, Dewan P, Puthoor AA, Chhabra T 等 2026 Aug 6 置信度 0.82
• AARS1-Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8(+)T Cells in Smoking-Related Emphysema.
  Emphysema is the primary pathological feature of chronic obstructive pulmonary disease (COPD). The accumulation of CD8 + T cells induces epithelial cell damage, thereby impairing the pulmonary alveolar niche. In this study, we demonstrated that CD8 + T cell ac…
  pubmed Zhu Y, Lin J, Li Y, Zhou Q 等 2026 Aug 6 置信度 0.82
• Janus Nanostructures Enabled by Confined Interfacial Engineering for Enhanced Electromagnetic Response.
  Regulating electromagnetic responses through interfacial design has attracted increasing attention, while the precise construction and mechanism understanding of asymmetric nano-interfaces remain largely unexplored, particularly at the nanoscale. Herein, takin…
  pubmed Song L, Song C, Hu F, Chen Y 等 2026 Aug 6 置信度 0.82
• Temporal Decoupling: A New Paradigm of 4D Photo-Responsive Carbon Dots Films With Modular Regulation of Color and Deformation.
  To address the key bottlenecks of traditional photo-responsive 4D materials, namely the inability to achieve independent regulation of photoinduced deformation and multicolor fluorescence, and the insufficient security of encryption systems, this study takes n…
  pubmed Zhang J, Meng M, Ma Z, Yue M 等 2026 Aug 6 置信度 0.82
• Emerging trends in bone marrow organoid research: From hematopoietic microenvironment reconstruction to translational and regenerative theranostic applications.
  Bone marrow organ is characterized as a dynamic tissue with a complex microenvironment wherein hematopoietic stem cell (HSC) homeostasis is maintained, and the generation of various hematopoietic cell subsets is regulated. Organoids technology has been applied…
  pubmed Park H, Jeong J 2026 置信度 0.82
• Optical digital twins for disease prevention, diagnosis, therapy, and intervention.
  Digital twins are transitioning from conceptual models to operational frameworks that link measurement, prediction, and intervention in biomedicine. However, most biomedical digital twin efforts remain fragmented, with limited integration across biological sca…
  pubmed Ozcan A, Skala MC, Pogue BW, Popp J 等 2026 Aug 置信度 0.82
• Quantitative MRI Pharmacokinetic Modeling and MALDI Mass Spectrometry Imaging Biodistribution of a pH Mapping MRI Contrast Agent.
  Chemical exchange saturation transfer (CEST) MRI enables noninvasive mapping of tissue pH, a key biomarker of renal physiology and disease. We report a streamlined, three-step synthesis of diGlu, an anionic imidazole-4,5-dicarboxamide bearing two glutamate sub…
  pubmed Mohanta Z, Tressler CM, Gori S, Singh A 等 2026 置信度 0.82