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• Dental school caries and periodontitis risk analysis skillset: survey of carryover to practice.
  Scarce evidence is available in how clinicians process the management of high-risk individuals in real-world scenarios. The purpose of the present study is to discern the degree to which graduates apply explicit risk analysis skillsets in practice over time, a…
  pubmed Johnsen DC, Garaicoa-Pazmino C, Jain A, Marchini L 等 2026 Jul 1 置信度 0.82
• Comparison of library preparation protocols and bioinformatic pipelines in high-throughput 16S rRNA gene sequencing.
  16S rRNA gene sequencing is widely used for bacterial community profiling in both clinical and research contexts. The expanding availability of library preparation protocols and bioinformatic pipelines increases analytical flexibility but may also introduce me…
  pubmed Andersson O, Fagerström A, Dannenberg K, Kekki J 等 2026 Jul 1 置信度 0.82
• Social Determinants of Health and Continuous Glucose Monitoring Metrics in Type 1 or Type 2 Diabetes.
  Race, ethnicity, and social determinants of health (SDOH) contribute to disparities in diabetes outcomes, particularly hemoglobin A1c (HbA1c). Although continuous glucose monitoring (CGM) improves glycemic management, it remains unclear whether associations pe…
  pubmed Williamson WT, Kok N, Lee JM, Wiens J 等 2026 Jul 1 置信度 0.82
• Intestinal Helminth Infections and Their Association With Nutritional Status and Diarrheal Diseases Among School-Aged Children in North Gondar Zone, Ethiopia.
  Intestinal helminth infections remain a major public health problem in low- and middle-income countries, particularly among school-aged children, where they contribute to malnutrition and diarrheal diseases. This study is aimed at assessing the prevalence of i…
  pubmed Alula GA, Endale T, Wudu M 2026 置信度 0.82
• Phenotypic similarity of adverse drug reactions and disease phenotypes is a bridge to mechanistic discovery.
  Adverse drug reactions (ADRs) remain a major barrier to safe therapeutic developments. A key challenge is our limited understanding of their underlying mechanisms. In this study, we investigated whether ADRs and diseases phenotypes (DPs) with similar clinical …
  pubmed Firoozbakht F, Wenke N, Tsoy O, Loscalzo J 等 2025 Aug 4 置信度 0.82
• The evolving role of the pathologist: Advancing from static reporting to dynamic, guideline-informed, multimodal precision diagnostics.
  Pathology and laboratory medicine is undergoing a transformation, moving from its roots in morphology to becoming a dynamic, multimodal field at the heart of precision medicine. This review outlines how diagnostic pathology has developed over time from morbid …
  pubmed Chitale DA 2026 Apr 1 置信度 0.82
• CSCN: inference of cell-specific causal networks using single-cell RNA-seq data.
  Understanding gene regulation is fundamental to deciphering the coordinated activity of genes within cells. Although single-cell RNA sequencing (scRNA-seq) enables gene expression profiling at cellular resolution, most gene network inference methods operate at…
  pubmed Wang M, Yang J, Lyu L, Chen J 2026 Jul 2 置信度 0.82
• Integrative analysis of semen quality and metabolomic profiles reveals breed-specific biomarker fertility in Indonesian buffalo.
  The increasing demand for animal protein in Indonesia underscores the importance of improving the productivity of indigenous buffalo breeds, which remain underutilized. Semen quality plays a central role in the success of artificial insemination, and metabolom…
  pubmed Bintara S, Prihantoko KD, Nurlatifah A, Maulana T 等 2025 Dec 置信度 0.82
• Hydrogen evolution and dynamics in hydrogel electrochemical cells for ischemia-reperfusion therapy.
  Molecular hydrogen (H 2 ) protects organs from reactive oxygen species damage associated with ischemia-reperfusion (I/R) injury. Existing H 2 delivery methods, such as gas inhalation and H 2 -rich water consumption, target the entire body and experience leakag…
  pubmed Li W, Zhang J, Nith R, Yue J 等 2025 Aug 置信度 0.82
• From molecular mechanisms to digital surveillance: the 2010-2025 evolution of benzodiazepine and Z-drug misuse research.
  The misuse of benzodiazepines (BZDs) and Z-drugs poses significant global public health challenges. This study maps the scientific evolution and paradigm shifts in this field from 2010 to 2025. A bibliometric analysis of 6,311 publications from the Web of…
  pubmed Liu J, Zhu W, Zhang Z, Zhao Q 等 2026 Jun 30 置信度 0.82
• Low-dose lithium vs valproate and incident dementia diagnoses in older adults: A propensity-matched cohort study using electronic health record data.
  Whether low-dose lithium lowers dementia incidence in older adults, relative to an active comparator, is unestablished in real-world data. We compared incident dementia in older adults receiving low-dose lithium versus valproate using a target trial emulation …
  pubmed da Silva AMP, Santos DH, Júnior DVSL, Cardoso LJC 等 2026 Oct 置信度 0.82
• A Redescription and Characterization of the Transcriptome of the Sea Anemone Edwardsia elegans (Verrill).
  Abstract Edwardsia elegans Verrill, 1869 is the most commonly encountered and discussed species of Edwardsia from North America. Although it is familiar and commonly cited in field guides, its anatomy, cnidom, life history, and molecular resources have been on…
  pubmed Rutlekowski A, Daly M, Reitzel AM 2025 Aug 置信度 0.82
• Next-generation non-animal models for inflammatory bowel disease: In vitro and in silico approaches for mechanistic understanding.
  Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn's disease, is a chronic and relapsing inflammatory condition of the gastrointestinal tract resulting from a complex interplay of oxidative stress, immune dysregulation, microbial imbal…
  pubmed Chougule PR, Sinha SN 2025 置信度 0.82
• CITOBOT AI for real-world cervical cancer screening using colposcopy imaging.
  Cervical cancer remains a major cause of morbidity and mortality among women, particularly in low- and middle-income countries, where delays in screening and diagnostic follow-up limit early detection. Artificial intelligence applied to medical imaging may str…
  pubmed Arrivillaga M, Neira D, Rivero DS, Vargas-Cardona HD 等 2026 置信度 0.82
• Bimekizumab rescue therapy in a patient with relapsing polychondritis-associated aortitis.
  Relapsing polychondritis (RP) is a rare inflammatory disease characterised by recurrent inflammation of cartilaginous structures, especially of the ears, nose and respiratory tract, with a broad spectrum of systemic features. Furthermore, cardiovascular involv…
  pubmed Kremer P, Melderis S, Ruffer N, Koehler D 等 2025 Jun 置信度 0.82
• Community state shifts driven by total carbon availability over resource complexity in a synthetic microbial community.
  Even though complex microbial communities are ubiquitous and provide essential services for natural and human-associated ecosystems, our knowledge about their assembly and dynamics is incomplete. There is an ongoing debate about whether the behavior of complex…
  pubmed Bischofberger AM, Cairns J, Aapalampi IK, Pausio S 等 2026 Jan 置信度 0.82
• Multi-cohort integration and machine learning identify CPVL as a novel oncogenic driver in gastric cancer.
  Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide, and the prognosis of advanced GC remains poor. Systematic identification of robust biomarkers through multi-cohort integration and computational prioritization may facilitate th…
  pubmed Li X, Chen J, Tian H, Zhang G 2026 Jun 27 置信度 0.82
• Integrated botanical and cultural strategies for management of major insect pests in maize.
  Maize (Zea mays L.) is a staple crop for millions of people worldwide, yet its productivity is constantly under threat from pests such as fall armyworm (Spodoptera frugiperda J.E. Smith), stem borers (Busseola fusca Fuller and Chilo partellus Swinhoe), maize a…
  pubmed Abera KY, Abate GA, Geremew MB 2026 May 5 置信度 0.82
• Antibody-trapping presents a widespread pitfall for microscopy and genomics in the nucleus.
  Chromatin has a complex 3D structure and diverse binding proteins that coordinate the genome's most essential functions. Many microscopy and genomics technologies that map chromatin proteins and modifications rely on the diffusion of antibodies (Abs) to target…
  pubmed Chudzik K, Sato Y, Yan X, Ullrich S 等 2026 Jun 22 置信度 0.82
• Clinical applications of digital twin technology in In Vitro Fertilisation.
  Digital twin technology, originating from aerospace and manufacturing industries, has emerged as a transformative tool in healthcare. In vitro fertilisation (IVF) faces persistent challenges including suboptimal embryo selection, unpredictable treatment outcom…
  pubmed Olawade DB, Abe OR, Nwazuo EK, Apena T 等 2026 Jun 26 置信度 0.82
• Patient-derived organoids across cancers reveal conserved tumor heterogeneity and actionable therapeutic vulnerabilities.
  We developed a pan-cancer patient-derived organoid (PDO) platform comprising 220 PDOs from 191 patients across 15 cancer types to advance functional precision oncology. Comprehensive characterization demonstrated high fidelity to parent tumors, with 93% histop…
  pubmed Kuo HH, Bhinder B, Gokozan HN, Gorski K 等 2026 Jun 26 置信度 0.82
• Bioinformatics-based Investigation to Unveiling The miRNA-Immunity Axis in The Tumor Microenvironment of Pancreatic Cancer.
  In this Bioinformatics study, we took in account the cell types variation of tumor microenvironment (TME) in Pancreatic Ductal Adenocarcinoma (PDAC), with a particular attention to miRNAs dysregulated pathways influencing immune responses, and especially memor…
  pubmed Al-Janaby MS, Mannoush SH, Al-Janabi SS, Suleiman AA 等 2025 置信度 0.82
• DARUMA: a gateway to fast and easy prediction of intrinsically disordered regions.
  Intrinsically disordered proteins (IDPs) are proteins that contain intrinsically disordered regions (IDRs), which lack stable three-dimensional structures under physiological conditions. These regions are known to play crucial roles in many biological processe…
  pubmed Shimizu I, Ida T, Ozawa Y, Fukuchi S 等 2025 置信度 0.82
• Report from the 9th Italian Society for Virology (SIV-ISV) 2025 Annual Meeting.
  The 9th National Congress of the Italian Society for Virology (SIV-ISV), entitled "One Virology-One Health", took place in Turin at the Centro Congressi Lingotto from 22 to 24 June 2025. The meeting highlighted recent multidisciplinary and translational develo…
  pubmed De Filippis A, Donalisio M, Luganini A, Caccuri F 等 2026 Jun 18 置信度 0.82
• Artificial Intelligence in the Design and Optimization of Orthodontic Materials: A Clinical Perspective on Current State and Future Directions.
  Artificial intelligence (AI) has transformed orthodontic diagnosis, yet its application to orthodontic materials science remains critically underexplored. This perspective identifies and characterizes the AI-materials integration gap as the central unresolved …
  pubmed Mikulewicz M, Paradowska-Stolarz A 2026 Jun 12 置信度 0.82
• Effectiveness of a Geographic Information System-Integrated Mobile Platform for Coordinating Early Stage Rehabilitation After Total Hip Arthroplasty: A Randomized Controlled Trial.
  Total hip arthroplasty (THA) is among the most effective orthopedic interventions for osteoarthritis, yet post-operative rehabilitation is frequently delayed due to informational and organizational barriers. Geographic information system (GIS) technology offer…
  pubmed Kurban Z, Bulekbayeva S, Slivkina N, Titskaya E 等 2026 Jun 3 置信度 0.82
• Genetic Architecture of Egg Production Traits in Chickens: A Systematic Review.
  Egg production in Gallus gallus domesticus represents a complex, economically critical trait shaped by multiple interrelated phenotypes, including age at first egg, total egg number, egg weight, and clutch characteristics. These traits are governed by polygeni…
  pubmed Kochetova O, Korytina G, Timasheva Y, Gilyazova I 等 2026 Jun 10 置信度 0.82
• From Primary Melanoma to Metastatic Evolution: AI-Powered Pathology Integrated with Functional Analysis and Clinical Metadata Improving Treatment Prediction.
  A critical gap in current efficiency in melanoma patient treatment is the lack of a fully integrated, functional understanding of tumor evolution over time. Recent advances have fundamentally reshaped our understanding of melanoma biology, while increasing cli…
  pubmed Fülöp L, Szadai L, Szigeti B, Christersson L 等 2026 Jun 16 置信度 0.82
• Neural Network Interpretation of the Intensity of Damage Processes to Biological Membranes of Human Cells, Depending on the Degree of Polymetallic Contamination of the Territory.
  Background: Lipid peroxidation is a primary driver of biological membrane damage and mediates the relationship between environmental exposure and adverse health outcomes. Malondialdehyde (MDA) is a widely recognized biomarker for quantifying oxidative stress i…
  pubmed Tunakova YA, Novikova SV, Valiev VS 2026 May 25 置信度 0.82
• Detection of Latent Tuberculosis Infection in Patients with Rheumatological Diseases Who Receive Immunosuppressive Therapy.
  Background/Objectives: Latent tuberculosis infection ( LTBI ) is a persistent immune response to Mycobacterium tuberculosis antigens in the absence of clinically active tuberculosis. It is now established that progression from LTBI to active tuberculosis is di…
  pubmed Starshinova A, Sabirova A, Maslyanskiy A, Grigorieva I 等 2026 Jun 17 置信度 0.82
• The Cerebrospinal Fluid Proteome of Alzheimer's Disease Patients: Differentiation and Prediction of Responders and Non-Responders to Lymphatic-Venous Anastomosis.
  Herein, we describe the identification of protein biomarkers in the cerebrospinal fluid (CSF) of Alzheimer's disease (AD) patients that enable the differentiation of Responders from Non-Responders to lymphatic-venous anastomosis (LVA). Discovery of these poten…
  pubmed Li Y, Du A, Zhang Q, Xu G 等 2026 Jul 14 置信度 0.82
• Decoding Gene-Disease Associations with Computational Methods: A Survey.
  Identifying gene-disease associations (GDAs) remains a fundamental challenge in biomedical research due to the enormous combinatorial space of candidate gene-disease pairs and the limited scalability of experimental validation. As wet lab studies cannot keep p…
  pubmed Zhai Y, Li M, Yu L, Wang X 等 2026 Jun 25 置信度 0.82
• Neuroretinal Layer Thinning on OCT Imaging and Hemoglobin A1c in Youth With Type 1 Diabetes.
  Diabetic retinal neurodegeneration precedes vascular changes associated with diabetic retinal disease (DRD). Studies in adults with type 1 diabetes (T1D) show there is retinal layer thinning with DRD, yet there are limited data in youth with T1D.
  pubmed Ramanujam S, Channa R, Liu TYA, Brown EA 等 2026 Aug 1 置信度 0.82
• Metabolic and vascular outcomes after transition to the MiniMed 780G system in adults ≥65 years with type 1 diabetes: a randomised, single-centre study.
  Hybrid closed-loop insulin delivery systems are increasingly regarded as the preferred therapy for type 1 diabetes, although evidence in older adults remains limited. The aim of this randomised study was to evaluate the effectiveness and safety of the MiniMed …
  pubmed Matejko B, Cyranka K, Suduł P, Susuł K 等 2026 Sep 置信度 0.82
• Quantitative Preclinical Imaging as a Metrological Framework: Reproducibility, Validation, and Translational Maturity.
  Quantitative preclinical imaging enables non-invasive characterization of physiological, molecular, and functional processes providing measurable biomarkers for longitudinal and translational studies. This review systematically analyzes 60 studies published be…
  pubmed Lauciello N, Russo G, Stefano A 2026 May 29 置信度 0.82
• The Strengthening of Quadriceps, Abductors, and External Rotator Muscles of the Hip to Alter Axial Alignment of the Lower Limbs in University Students with Patellofemoral Pain Syndrome: A Prospective Cohort Study.
  Background : Proximal lower-extremity muscle strengthening is an important conservative intervention for patellofemoral pain syndrome (PFPS), as these muscle groups play critical roles in femoral stabilization and knee valgus control. However, evidence remains…
  pubmed Carvalho RAG, Pizzolato BB, Souza GPA, Minussi Filho E 等 2026 Jun 1 置信度 0.82
• The Application of Metabolomics in Frailty: Trends, Challenges, and Future Directions.
  Frailty is a geriatric syndrome involving inflammation, oxidative stress, mitochondrial dysfunction, and metabolic disturbances. Metabolomics can systematically elucidate metabolic pathways and identify actionable biomarkers. This study systematically reviews …
  pubmed Fang K, Niu B, Zhang Z, Jiang Y 等 2026 May 31 置信度 0.82
• Bioinformatics Strategy for 16s and 23s rRNA Metabarcoding Data.
  Understanding biological communities is essential for elucidating ecosystem structure and function. Metabarcoding based on ribosomal RNA (rRNA) genes, particularly 16S and 23S, is widely used to characterise bacterial and microalgal communities. However, analy…
  pubmed Domingues R, Pires JCM 2026 Jun 8 置信度 0.82
• Global Research Landscape and Thematic Evolution of Fungi-Derived Antimicrobials Against Methicillin-Resistant Staphylococcus aureus (MRSA): A Scientometric Analysis.
  Methicillin-resistant Staphylococcus aureus (MRSA) remains a significant multidrug-resistant pathogen, frequently associated with persistent infections and biofilm formation, underscoring the urgent need for alternative antimicrobial strategies. Bioactive comp…
  pubmed Ong CJN, Fortaleza JAG, Ramos ED, Cabuhat KSP 等 2026 Jun 19 置信度 0.82
• Research trends and potential molecular intersections between diabetic kidney disease and sarcopenia: a 21-year bibliometric and bioinformatics analysis.
  Diabetic kidney disease (DKD) and sarcopenia are increasingly recognized as clinically relevant and potentially interrelated conditions in diabetes, aging, metabolic dysfunction, and functional decline. However, the global research landscape, evolving hotspots…
  pubmed Liu F, Liu H, Peng S 2026 置信度 0.82
• Determinants of precancerous cervical lesions among women screened for cervical cancer at Debre Markos town public health facilities, Ethiopia.
  The potential for precancerous cervical lesions to develop into cervical cancer over time is a significant public health concern in low and middle-income countries, including Ethiopia. The Ethiopian government is supporting the prevention of cervical cancer by…
  pubmed Belayneh Y, Abneh AA, Mengist A, Kassie TD 等 2026 Jun 24 置信度 0.82
• Neurodiagnostic: Advances in diagnostic tools.
  Understanding the pathologies related to neurological issues, viz. Alzheimer's disease (AD), brain tumors, and multiple sclerosis (MS) are complex and still lack effective therapeutics. Management of the global health burden caused by the escalating cases of n…
  pubmed Dave S, Banerjee J, Banerjee S, Tiwari AK 2026 置信度 0.82
• Allergenic and Antigenic Properties of Goat's Milk Caseins and Their Mitigation Strategies: A Review.
  Goat's milk is increasingly considered an alternative to cow's milk for infants due to its potential health benefits. However, casein allergenicity and antigenicity, including potential cross-reactivity with cow's milk, remain important public health concerns.…
  pubmed Samsudin NINM, Sukor R, Mohsin AZ, Arulrajah B 等 2026 Jul 置信度 0.82
• Advances in oral disease models: a mini-review of developments from 2015 to 2025.
  Oral diseases represent one of the most widespread global health burdens, affecting billions of people worldwide, causing pain, disability, and substantial treatment costs. Despite their prevalence, progress in prevention and therapy has been limited, in part,…
  pubmed Huang J, Le-Tran J, Kobayashi NS, Kobayashi Y 等 2026 置信度 0.82
• 4-Nonylphenol mediated tumor progression and immune modulation through CDK2: Computational and experimental validation.
  As an endocrine-disrupting chemical, 4-nonylphenol (4-NP) has been found above safe limits in global water systems and associated with cancer progression. This multidisciplinary study systematically investigated the carcinogenic mechanisms of 4-NP by integrati…
  pubmed Zhou X, Wei Y, Tu Y, Yan M 等 2026 Aug 置信度 0.82
• Modeling framework to demonstrate elimination of a vector population: Tsetse elimination in Chad.
  Every year, over 700,000 people, particularly children under five, die from vector-borne diseases worldwide. Effectively controlling endemics and preventing new outbreaks requires an integrated approach that can lead to the elimination of both vectors and dise…
  pubmed Hargrove J, Mahamat MH, Aldjibert M, Yoni W 等 2026 Jun 30 置信度 0.82
• Application of deep learning in crop research: From genomics to phenomics.
  Deep learning, as a pivotal branch of machine learning, has demonstrated remarkable potential in advancing crop science by effectively integrating genomics and phenomics. This review systematically outlines the application of diverse deep learning architecture…
  pubmed Wu Z, Sun Y, Luo Q, Wei J 等 2026 Jun 置信度 0.82
• Predicting piRNA-Disease Associations Based on Dual-View Learning and Multi-head Self-Attention Mechanism Fusion.
  PIWI-interacting RNAs (piRNAs) are an important class of non-coding RNA molecules in epigenetic regulation. It plays a crucial role in maintaining genomic stability and inhibiting transposable elements, and have been proven to participate in various diseases b…
  pubmed Zheng M, Fang Y, Na L, Zhao Q 2026 Jun 22 置信度 0.82
• Co(II), Cu(II), and Ni(II) Coordination Complexes: Synthesis, Characterization, Experimental, and Computational Study on Potential Antiplasmodial Activity.
  In this work, the synthesis and structural characterization of coordination complexes C1 (Co-Cl), C2 (Cu-Cl), C3 (Co-Br), and C4 (Ni-Cl) with the ligand 2-(tert-butoxy)-6-(1H-imidazol-1-yl)pyridine (L) was carried out. The X-ray diffraction reveals the presenc…
  pubmed Ezenarro-Salcedo D, Fonseca-López D, Patiño-Cubides A, Velasco-Pareja MC 等 2026 Jun 26 置信度 0.82
• Analytical calculation of the dose to a spherical target by an ion at almost all impact parameters, and calculation of the energy deposition spectra.
  Microdosimetry can be used to estimate or evaluate quality factors for risk assessment in radiation protection and to quantify relative biological effectiveness for treatment planning of hadron radiation therapy. Radiation physics has shown that energetic ions…
  pubmed Plante I, Poignant F, Slaba TC 2026 Jul 置信度 0.82
• Airborne spread of severe acute respiratory syndrome coronavirus 2 between rooms in a sealed, mechanically ventilated ward: Evidence from a hospital outbreak investigation.
  Airborne transmission of severe acute respiratory syndrome coronavirus 2 in enclosed, mechanically ventilated hospital wards remains poorly characterized. In February 2025, a coronavirus disease cluster involving 17 individuals occurred across multiple rooms i…
  pubmed Ishigaki Y, Fujita N, Kato T, Ochiai T 等 2026 置信度 0.82
• Youth Soccer Participation and Brain Health Outcomes in Adolescent Athletes.
  Repetitive head impacts (RHIs) are associated with later-life neurodegeneration. Because soccer is the most widely played sport among youth worldwide, identifying early changes associated with RHI is important.
  pubmed Koerte IK, Wiegand TLT, Bonke EM, Sandmo SK 等 2026 Jun 1 置信度 0.82
• Deep learning enabled decision support systems in epilepsy surgery: a scoping review.
  Deep learning is increasingly explored to support decision-making in epilepsy surgery, yet evidence for implementation across the epilepsy surgery pathway remains limited. We conducted a scoping review of 145 studies published between January 2018 and May 2025…
  pubmed Yu K, Zhou S, Song M, Zhan Z 等 2026 置信度 0.82
• Retraction notice to "Bacteriophages as an alternative strategy for the treatment of drug resistant bacterial infections: Current approaches and future perspectives" [Cell Surf. 14 (2025) 100149].
  [This retracts the article DOI: 10.1016/j.tcsw.2025.100149.].
  pubmed Girma A 2026 Jun 置信度 0.82
• Epidemic features and potential impact of vaccine campaigns on the 2025 chikungunya outbreak in southern China: a mathematical modelling study.
  Chikungunya virus (CHIKV), an emerging arbovirus, is transmitted by Aedes mosquitoes. Climate change and increasing population mobility have driven recent outbreaks beyond traditional endemic regions. Since early July 2025, Guangdong province in southern China…
  pubmed Zheng Q, Ding Y, Wang X, Yang Y 等 2026 Aug 置信度 0.82
• JADE: Joint Alignment and Deep Embedding for Multi-Slice Spatial Transcriptomics.
  As spatially resolved transcriptomics (SRT) datasets increasingly span multiple adjacent or replicated slices, effective joint analysis across slices is needed to reconstruct tissue structures and identify consistent spatial gene expression patterns. This requ…
  pubmed Guo Y, Liu JS, Cheng H, Ma Y 2025 Dec 置信度 0.82
• The PER2:BRCA1:POU2F1(OCT-1) ternary complex represents a multi-component scaffold model for circadian gene regulation.
  The circadian clock component PER2 coordinates daily oscillations in gene expression across multiple tissues, yet its role in assembling multi-protein regulatory complexes remains incompletely understood. Here, we report that PER2 nucleates a ternary complex w…
  pubmed Kadukhina E, Jia S, Villa LM, Yi X 等 2026 May 置信度 0.82
• A Comprehensive Genomic Investigation of Mumps Virus Genotype G Isolates from Dibrugarh, Assam: Insights from Whole Genome Analysis.
  Mumps, caused by Mumps virus (MuV) in the Paramyxoviridae family, features a 15,384 nucleotide RNA genome. Despite vaccination efforts, mumps outbreaks persist, particularly in regions with optional vaccination policies like India. Therefore, this study aims t…
  pubmed Sarmah K, Sarma K, Borkakoty B, Borah PK 等 2026 Jun 置信度 0.82
• Machine learning-guided risk stratification in elderly AML based on genomic, immunophenotypic and therapeutic profiles.
  Elderly patients with acute myeloid leukemia (AML) exhibit considerable biological and clinical heterogeneity, hindering precise prognosis. Existing prognostic systems inadequately capture the complexity of elderly AML due to their reliance on data from younge…
  pubmed Zhang L, Liu J, Liang J, Zhang X 等 2026 Jun 22 置信度 0.82
• Effects of Different Training Modalities on Circulating Irisin Levels in Overweight and Obesity Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
  Irisin is an exercise-induced myokine that has been proposed to exert beneficial effects on metabolic health. However, its response to different exercise training modalities in individuals with overweight or obesity remains inconsistent. This systematic review…
  pubmed Hejazi K, Mohammad Rahimi GR, Saeidi A, Ayed K 等 2026 Sep 置信度 0.82
• DCPM-ADMET: fusion of dual-component pre-trained model and molecular fingerprints to enhance drug ADMET properties prediction.
  The absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of drugs are critical to their efficacy and safety in clinical trials; however, traditional machine learning methods have limited generalization ability in ADMET prediction du…
  pubmed Zhang L, Zeng Y, Qi Y, Jiang K 等 2026 Jun 20 置信度 0.82
• Effectiveness of abdominal hollowing and piriformis stretching exercises in spondylolisthesis patients: a study protocol for a randomized controlled trial.
  Lumbar spondylolisthesis is a clinically important cause of chronic low back pain, activity limitation, and reduced functional capacity. Exercise-based physiotherapy is widely recommended for conservative management, yet uncertainty remains regarding the added…
  pubmed Dey G, Hossain MA, Halder P, Huda MN 等 2026 Jun 20 置信度 0.82
• The role of protein embeddings for protein-protein interaction prediction with graph neural networks.
  Graph neural networks are a natural fit for protein-protein interaction (PPI) prediction because they exploit the graph structure of interactomes, yet it remains unclear how much they benefit from protein-level representations and which sources of protein info…
  pubmed Balbi L, Sousa RT, Cotovio P, Pesquita C 2026 May 4 置信度 0.82
• Computational prediction of replication origins: a comparative review of methods, benchmarks, and trends from heuristics to deep learning.
  Origins of DNA replication (Ori) are genomic loci where DNA synthesis begins, essential for bacterial viability, eukaryotic development, and genome integrity. While early computational methods relied on compositional skews and motif heuristics, recent years ha…
  pubmed Jomaa H, Assaf R 2026 May 4 置信度 0.82
• Computational Fluid Dynamics Reveals Mass Transfer Limitations in a Pilot-Scale Microbial Electrolysis Cell.
  The scalability of microbial electrochemical technologies (METs), particularly microbial electrolysis cells (MECs), is constrained by hydrodynamic and mass transfer limitations that hinder efficient resource recovery from wastewater. This study presents a comp…
  pubmed Guerrero-Sodric O, Navarro-Quispe RJ, Cortada-García M, Baeza JA 等 2026 Jun 置信度 0.82
• Supercritical fluid chromatography in food analysis: a survey of the last three-year period.
  Supercritical fluid chromatography (SFC) has evolved into a versatile, high-performance analytical technique with compelling advantages in food analysis in terms of speed, resolution, and sustainability. This minireview surveys the substantial advancements in …
  pubmed Arena A, Russo M, Donato P, Zoccali M 等 2026 Jul 2 置信度 0.82
• The DARO-flare trial: evaluating the impact of darolutamide on prostate-specific membrane antigen (PSMA) flare and its implications for imaging and staging of hormone-sensitive prostate cancer - study protocol.
  Prostate cancer (PCa) represents a major global health concern due to biological heterogeneity and the complexity of its underlying molecular pathways, which contribute to substantial morbidity and mortality. Ongoing research continues to elucidate distinct mo…
  pubmed van der Gaag S, Vis A, Bartelink I, Hendrikse H 等 2026 Jun 18 置信度 0.82
• C-terminal long-QT type 1 R562S-Kv7.1 variant, the first variant in helix C impairing β-adrenergic response of the slow delayed rectifier K+ channel.
  Kv7.1 variants, associated with long QT syndrome type 1 (LQT1) and altering the function of the slow delayed rectifier K+ (IKs) channel, may result in arrhythmias, especially during exercise. This study focused on complex analysis of the R562S-Kv7.1 variant lo…
  pubmed Král M, Švecová O, Kula R, Kadášová N 等 2026 Jul 3 置信度 0.82
• Fluorescence Lifetime and Smartphone-Enabled Detection of Amyloid-β for Diagnosis and Staging in Alzheimer's Disease.
  Alzheimer's disease (AD) is characterized by the pathological aggregation of amyloid-β (Aβ) peptides into plaques that drive neurodegeneration and cognitive decline. As Aβ remains the central and pathological biomarker for early and definitiv…
  pubmed Bhagavath KK, Ramesh M, Kumar Y, Mandal S 等 2026 Aug 5 置信度 0.82
• The Nexus Framework: A Unified Prestack for Emergent Structure Across Domains
  The Nexus Framework: A Unified Prestack for Emergent Structure Across Domains Driven by Dean A. Kulik August, 2025 Abstract This thesis presents a comprehensive unification of the Nexus Framework across mathematics, physics, computation, biology, cognitive sci…
  datacite Kulik, Dean 2025 置信度 0.66
• The Nexus Framework: A Unified Prestack for Emergent Structure Across Domains
  The Nexus Framework: A Unified Prestack for Emergent Structure Across Domains Driven by Dean A. Kulik August, 2025 Abstract This thesis presents a comprehensive unification of the Nexus Framework across mathematics, physics, computation, biology, cognitive sci…
  datacite Kulik, Dean 2025 置信度 0.66
• The Nexus Framework: A Unified Prestack for Emergent Structure Across Domains
  The Nexus Framework: A Unified Prestack for Emergent Structure Across Domains Driven by Dean A. Kulik August, 2025 Abstract This thesis presents a comprehensive unification of the Nexus Framework across mathematics, physics, computation, biology, cognitive sci…
  datacite Kulik, Dean 2025 置信度 0.66
• Theoretical Implications of Localized Stability in the Nexus Recursive Harmonic Framework
  Theoretical Implications of Localized Stability in the Nexus Recursive Harmonic Framework Driven by Dean KulikNovember 2025 Abstract This comprehensive research report investigates the theoretical foundations and systemic implications of a localized stability …
  datacite Kulik, Dean 2025 置信度 0.66
• Theoretical Implications of Localized Stability in the Nexus Recursive Harmonic Framework
  Theoretical Implications of Localized Stability in the Nexus Recursive Harmonic Framework Driven by Dean KulikNovember 2025 Abstract This comprehensive research report investigates the theoretical foundations and systemic implications of a localized stability …
  datacite Kulik, Dean 2025 置信度 0.66
• BBP and the Informational Mirror: A Recursive Harmonic Interpretation of Modular Access
  BBP and the Informational Mirror: A Recursive Harmonic Interpretation of Modular Access Driven By Dean a, Kulik August,2025 Introduction The Bailey–Borwein–Plouffe (BBP) formula for π is renowned as a “spigot” algorithm that can directly compute the $n$th digi…
  datacite kulik, dean 2025 置信度 0.66
• A Theoretical Framework for Monolithic Neural–Computational Integration at the Quadrillion-Parameter Scale
  This paper proposes the Singularity Implant (SI), a theoretical framework for the integration of brain–computer interfaces, neuromorphic computing, and extremely large artificial intelligence models within a future intracranial computational platform. The prop…
  datacite Revista, Zen 2026 置信度 0.66
• A Measured Quantum–Classical Resource Asymmetry on IBM Kingston: Empirical Grounding for the Computational Argument in the Quantum-Simulator Hypothesis
  Amit Brahmbhatt Quantum-Clarity LLC Email: amit@quantum-clarity.com Date: April 2026 Platform: IBM Kingston (156-qubit Heron r3 heavy-hex superconducting processor) Related deposits: PBR-inspired entanglement validation — Zenodo DOI 10.5281/zenodo.17883261 Y⊗Z…
  datacite Brahmbhatt, Amit 2026 置信度 0.66 quantum computing; IBM Kingston; Heron r3; resource asymmetry; quantum advantage; quantum simulation; classical simulation; Hilbert space scaling; state-vector memory; random quantum circuits; computational complexity; quantum-simulator hypothesis; simulation hypothesis; quantum foundations; Feynman quantum simulator; Lloyd programming the universe; native-edge circuits; heavy-hex topology; NISQ benchmarking; superconducting qubits; exponential scaling; scaling study
• Publication: Records Broken by N-K Universal Computer with 10³⁰⁰ Entangled N-Pairs   Complete Inventory of Computational, Scientific, and Theoretical Records Shattered By Malik Muhammad Usman Multan, Pakistan.
  Publication: Records Broken by N-K Universal Computer with 10³⁰⁰ Entangled N-Pairs Complete Inventory of Computational, Scientific, and Theoretical Records Shattered By Malik Muhammad Usman Multan, Pakistan. --- Publication Metadata Field Value Title Complete …
  datacite Usman Malik, Muhammad 2026 置信度 0.66
• FatherTimeSDKP framework falsifiable validation though academic research
  Mainstream Peer-Reviewed".: Referenced Manuscript ID 8a12ae07-0c23-4e3e-9cab-65b440cd2131 as the "Verification Key" Geometric Necessity, Mass Potential, and Density Limits: A Unified Principle for Structural Integrity and Polynomial Tractability in the Straine…
  datacite Smith, Donald Paul 2025 置信度 0.66 FatherTimeSDKPSDKPNew physicsQCCMeta
• FatherTimeSDKP framework falsifiable validation though academic research
  Mainstream Peer-Reviewed".: Referenced Manuscript ID 8a12ae07-0c23-4e3e-9cab-65b440cd2131 as the "Verification Key" Geometric Necessity, Mass Potential, and Density Limits: A Unified Principle for Structural Integrity and Polynomial Tractability in the Straine…
  datacite Smith, Donald Paul 2025 置信度 0.66 FatherTimeSDKPSDKPNew physicsQCCMeta
• Two-Dimensional Neuromorphic Electronic Materials and Devices
  The exponentially improving performance of digital computers has recently slowed due to the speed and power consumption issues resulting from the von Neumann bottleneck. In contrast, neuromorphic computing aims to circumvent these limitations by spatially co-l…
  datacite Dr. Mark C. Hersam 2026 置信度 0.66
• Two-Dimensional Neuromorphic Electronic Materials and Devices
  The exponentially improving performance of digital computers has recently slowed due to the speed and power consumption issues resulting from the von Neumann bottleneck. In contrast, neuromorphic computing aims to circumvent these limitations by spatially co-l…
  datacite Dr. Mark C. Hersam 2026 置信度 0.66
• CUQDyn1_Plus: Hybrid Conformal–Gaussian Uncertainty Quantification for Partially Observed ODE Systems
  Overview CUQDyn1_Plus is a MATLAB toolbox for parameter estimation and uncertainty quantification (UQ) in ordinary differential equation (ODE) models where only a subset of state variables are experimentally observed. It addresses the common practical situatio…
  datacite Alberto, Portela, Banga, Julio R. 2026 置信度 0.66 uncertainty quantificationsystems biologydynamical systemsODEssystem identification
• CUQDyn1_Plus: Hybrid Conformal–Gaussian Uncertainty Quantification for Partially Observed ODE Systems
  Overview CUQDyn1_Plus is a MATLAB toolbox for parameter estimation and uncertainty quantification (UQ) in ordinary differential equation (ODE) models where only a subset of state variables are experimentally observed. It addresses the common practical situatio…
  datacite Alberto, Portela, Banga, Julio R. 2026 置信度 0.66 uncertainty quantificationsystems biologydynamical systemsODEssystem identification
• 2024_2025_Dynalife_Evora_Training School
  ##Training School: "Dynamical Systems and Biological Information: Exploring the Next Frontier" This school is designed to provide essential insights into bridging the general theory of dynamical systems with the informational content of genetic sequences, both…
  datacite Dynalife WG4 2025 置信度 0.66
• Microscopy dataset and image analysis code from timelapse imaging of individual steps in the lytic bacteriophage life cycle in single bacterial cells
  IntroductionThis dataset is a companion to the work presented in the preprint “Single-cell imaging of the lytic phage life cycle in bacteria” [1]. If you use this dataset in your work, please cite our preprint. A full description of the scientific objectives, …
  datacite Charlie Wedd, Ruizhe Li, Temur Yunusov, Aaron Smith 等 2026 置信度 0.66 VirologyMicrobiologyBiophysicsPhagesingle-cell
• Data from: Oblong turtles hybridise with an introduced congener and display a size-heterozygosity relationship
  Freshwater turtles are among the most imperiled vertebrate groups globally, facing compounding threats from habitat loss, climate change, and invasive species. We conducted the first comprehensive range-wide genomic assessment of the oblong turtle (Chelodina o…
  datacite von Takach, Brenton, Santoro, Anthony, Sturm, April, Thorn, Kailah 等 2026 置信度 0.66 FOS: Biological sciencesTurtlesHybridizationFreshwater ecologyPopulation genetics
• Andampindambrahmandam (APB): Universal Research Database Engine for Cross-Scale Physics and Omics v 0.8
  Andampindambrahmandam (APB)Genome-Based Quantum Computing Through Particle Language ModelsCopyright © 2026 Coding Photon Pvt Ltd. All Rights Reserved. Published for academic visibility and collaboration inquiries only. Commercial use requires written permissio…
  datacite Sankaramanchi, Raghavendra Rao 2026 置信度 0.66
• WHONDRS 2016 Sediment Organic Matter Characterization Data from Streams across HJ Andrews Experimental Forest, Oregon
  This dataset supports a broader synoptic effort to map morphological, hydrological, chemical, and biological conditions across a fifth-order mountain stream network. Samples were generated through a collaborative synoptic sampling effort in 2016. The dataset p…
  datacite Stegen, James C., Chu, Rosalie, Danczak, Robert E., Forbes, Brieanne 等 2026 置信度 0.66 River corridorSurface waterFreshwaterRiverStream
• Data from: No consistent effect of migration on speciation rates in two avian superfamilies: A check on the robustness of trait-dependent diversification methods
  Seasonal migration is performed by taxonomically diverse groups across the planet’s oceans and continents. Migration has been hypothesized to promote speciation through a variety of mechanisms that may initiate reproductive isolation and population divergence,…
  datacite Calabrese, Gina, Delmore, Kira, Wolf, Jochen, Safran, Rebecca 等 2026 置信度 0.66 migrationSpeciationDiversificationcomparative phylogeneticsAves
• The relationship between environmental stress and inbreeding depression in populations of animals and plants: a data resource for meta-analysis (Version 1.0)
  This dataset comprises data and code needed to support meta-analyses on the relationship between inbreeding depression and environmental variation and stress, in populations of animals and plants. These materials are sufficient to replicate all analyses and fi…
  datacite Chan, Yuan-Fu, Hodgson, jenny, Whitlock, Raj 2027 置信度 0.66
• CHESS 2025: Leaf Area Index (LAI) for meadow, shrub, tree, and understory vegetation
  This dataset contains Leaf Area Index (LAI) measurements made as part of the Colorado Headwaters Ecological Spectroscopy Study (CHESS) during June and July of 2025. Data were collected in the Upper Gunnison Basin, Colorado, across three study domains: the Uppe…
  datacite Todorov*, Sophia, Worsham*, H. Marshall, Breckheimer, Ian, Henderson, Amanda 等 2026 置信度 0.66 EARTH SCIENCE > BIOSPHERE > VEGETATION > LEAF CHARACTERISTICS > LEAF AREA INDEX (LAI)EARTH SCIENCE > BIOSPHERE > VEGETATION > VEGETATION INDEX > LEAF AREA INDEX (LAI)EARTH SCIENCE > BIOSPHERE > VEGETATION > CANOPY CHARACTERISTICSEARTH SCIENCE > ATMOSPHERE > ATMOSPHERIC RADIATION > TRANSMITTANCEEARTH SCIENCE > BIOSPHERE > VEGETATION > CANOPY TRANSMITTANCE
• The Operational Geometry of the Computational Substrate Querying the Non-Linear Field and Defining the Cryptanalytic Frontier
  The Operational Geometry of the Computational Substrate Querying the Non-Linear Field and Defining the Cryptanalytic Frontier Driven by Dean Kulik June 2026 1. The Shape of the Field: Non-Linear Triadic Geometry and Orthogonal States The fundamental barrier to…
  datacite kulik, dean 2026 置信度 0.66
• The Operational Geometry of the Computational Substrate Querying the Non-Linear Field and Defining the Cryptanalytic Frontier
  The Operational Geometry of the Computational Substrate Querying the Non-Linear Field and Defining the Cryptanalytic Frontier Driven by Dean Kulik June 2026 1. The Shape of the Field: Non-Linear Triadic Geometry and Orthogonal States The fundamental barrier to…
  datacite kulik, dean 2026 置信度 0.66
• DetectoWipe™: Novel Conceptual Multi-Zone Colorimetric Toilet Wipe for Early Colorectal Cancer Detection via Dual Chromogenic Linkage and Reaction Cascade Amplification
  LinkedIn: Jason Shen | LinkedIn Before anyone begins to deep dive into this document, I want to touch upon one of the most critical foundations of the DetectoWipe work: yes, the invention is very novel and nonobvious and would likely be able to be converted in…
  datacite Jason Shen 2026 置信度 0.66
• DetectoWipe™: Novel Conceptual Multi-Zone Colorimetric Toilet Wipe for Early Colorectal Cancer Detection via Dual Chromogenic Linkage and Reaction Cascade Amplification
  LinkedIn: Jason Shen | LinkedIn Before anyone begins to deep dive into this document, I want to touch upon one of the most critical foundations of the DetectoWipe work: yes, the invention is very novel and nonobvious and would likely be able to be converted in…
  datacite Jason Shen 2026 置信度 0.66 colorectal cancer screening, home stool test, colorimetric assay, diagnostic wipe, polymer microencapsulation, multi-zone reaction, paper-based biosensor, low-cost diagnostic
• Lux Ferox Research Collective — A Holographic-Thermodynamic Ontology of Information: From Planck-Scale Substrates to Civilizational Cognitive Warfare
  Lux Ferox Research Collective — A Holographic-Thermodynamic Ontology of Information: From Planck-Scale Substrates to Civilizational Cognitive Warfare (Working Paper Series, v16 — April 2026) DESCRIPTION Lux Ferox is an independent research initiative applying …
  datacite MATHIEU, François 2026 置信度 0.66 Artificial intelligenceArtificial IntelligenceMilitary ScienceMilitary FacilitiesMilitary equipment
• Lux Ferox Research Collective — A Holographic-Thermodynamic Ontology of Information: From Planck-Scale Substrates to Civilizational Cognitive Warfare
  Lux Ferox Research Collective — A Holographic-Thermodynamic Ontology of Information: From Planck-Scale Substrates to Civilizational Cognitive Warfare (Working Paper Series, v16 — April 2026) DESCRIPTION Lux Ferox is an independent research initiative applying …
  datacite MATHIEU, François 2026 置信度 0.66 Artificial intelligenceArtificial IntelligenceMilitary ScienceMilitary FacilitiesMilitary equipment
• An Optimization Framework for Automated Assessment of Biological Plausibility of Spiking Neurons
  Biological plausibility is a key concept in neuromorphic computing and spiking neural networks, yet it remains inconsistently defined and difficult to quantify. In this work, we present an open-source framework for the automated assessment of biological plausi…
  datacite Nitzsche, Sven, Ionita, Alexandru, Faust, Andreas, Ionescu, Bogdan 等 2026 置信度 0.66 Neural and Evolutionary Computing (cs.NE)FOS: Computer and information sciencesFOS: Computer and information sciences
• scMRDR: A scalable and flexible framework for unpaired single-cell multi-omics data integration
  Advances in single-cell sequencing have enabled high-resolution profiling of diverse molecular modalities, while integrating unpaired multi-omics single-cell data remains challenging. Existing approaches either rely on pair information or prior correspondences…
  datacite Sun, Jianle, Liang, Chaoqi, Wei, Ran, Zheng, Peng 等 2025 置信度 0.66 Quantitative Methods (q-bio.QM)Machine Learning (cs.LG)Genomics (q-bio.GN)FOS: Biological sciencesFOS: Biological sciences