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ABSTRACT Predicting protein–ligand binding affinity is a fundamental challenge in computational biology and drug discovery, complicated by diverse factors including protein sequence variability, ligand chemical diversity, and structural resolution. Here, we pr…
preprints
2025
置信度 0.74
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Accurate prediction of cognitive states such as psychological stress from electroencephalography (EEG) remains a significant challenge due to the inherently spatiotemporal and nonlinear nature of brain dynamics. To address these complexities, we propose NeuroG…
preprints
2025
置信度 0.74
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AI-assisted thyroid nodule evaluation shows promise in improving thyroid nodule detection, which can be missed by ultrasound(US)-guided hand-held transducer due to the complexity of nodules segmentation. this paper proposed the paper proposes an efficient 4-le…
preprints
2025
置信度 0.74
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Spiking Neural Networks (SNNs) have emerged as a promising paradigm for energy-efficient and event-driven computing, drawing inspiration from biological neurons. Recent research has introduced novel methods to enhance the performance, robustness, and hardware …
preprints
2025
置信度 0.74
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Abstract Brain-inspired reinforcement learning (RL) represents a pivotal pathway toward artificial general intelligence, yet existing hardware implementations based on artificial neural networks lack critical biological mechanisms like third-terminal modulated…
preprints
2025
置信度 0.74
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Motivation Modern genomic research is driven by next-generation sequencing experiments such as ChIP-seq, CUT&Tag, and CUT&RUN that generate coverage files for transcription factor binding, as well as ATAC-seq that yield coverage files for chromatin accessibili…
preprints
2025
置信度 0.74
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Abstract Transition metal oxides (TMOs) are a promising class of materials for neuromorphic computing and processing systems demonstrating a variety of resistive switching (RS) mechanisms. However, little is known about the correlation between its stoichiometr…
preprints
2025
置信度 0.74
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In this paper, we present the Genomic Compute Trifecta, which are the fundamental structural barriers to scalable computation of genomics and multi-omics workloads due to the complexity of the data structure and its incompatibility with the assumptions underpi…
preprints
2025
置信度 0.74
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The demand for computing power has been growing exponentially with the rise of artificial intelligence (AI), machine learning, and the Internet of Things (IoT). This growth requires unconventional computing primitives that prioritize energy efficiency, while a…
preprints
2025
置信度 0.74
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Abstract Machine learning algorithms enable computers to learn autonomously by emulating human intelligence, but they require considerable electronic computational resources, increasing costs for big data processing. To address the burgeoning demand for comput…
preprints
2025
置信度 0.74
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Characterising the mechanisms underlying naturalistic defensive behavior remains a significant challenge. While substantial progress has been made in unravelling the neural basis of tightly constrained behaviors, a critical gap persists in our comprehension of…
preprints
2025
置信度 0.74
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Abstract Single-cell RNA sequencing (scRNA-seq) enables high-resolution analysis of cellular heterogeneity, but traditional cell isolation methods like flow cytometry and laser microdissection often suffer from limitations in efficiency, viability, and bias. T…
preprints
2025
置信度 0.74
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Do you need a body to be an intelligent system? Clearly not. Artificial systems such as Large Language Models do not have a body and yet they are promptly qualified as intelligent and even conscious. But what exactly is intelligence? And do you need a body to …
preprints
2025
置信度 0.74
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Species tree estimation from multi-copy gene family trees, including both paralogs and orthologs, is a challenging task due to the gene tree discordance caused by biological processes such as incomplete lineage sorting (ILS) and gene duplication and loss (GDL)…
preprints
2025
置信度 0.74
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The neural information organizing and processing principles are presented in a general transdisciplinary axiomatic form, highlighting the fundamental neural informational characteristics and processes as a guiding informational synthesis useful in various fiel…
preprints
2025
置信度 0.74
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The identification of RNA motifs plays a crucial role in understanding biological functions, predicting RNA 3D structures, and designing RNA-based therapeutics. One of the efficient strategies approaches this task by analyzing secondary structure graphs annota…
preprints
2025
置信度 0.74
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RNA plays a wide variety of roles in biological processes. In addition to serving as the coding messenger RNA (mRNA), the vast majority of RNAs function as non-coding RNAs (ncRNAs), where their dynamic structural ensemble is critical for mediating diverse biol…
preprints
2025
置信度 0.74
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Abstract In the human brain, a specialized type of pyramidal neuron dendrite exhibits nonlinear spike integration and sparse parallel processing capabilities. This unique structure enables efficient execution of visual tasks by activating only a small subset o…
preprints
2025
置信度 0.74
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With the development of sequencing technologies, chromosome-level genome assemblies have become increasingly common across various organisms, including non-model species. BLAST+ is one of the most widely used bioinformatics tools for computing sequence alignme…
preprints
2025
置信度 0.74
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Abstract Neuromorphic computing aims to replicate the parallel, adaptive nature of biological intelligence in electronic systems. Despite considerable advances in memristor technology, material-encoded neurosynaptic bifunctionality has not been demonstrated. W…
preprints
2025
置信度 0.74
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The convergence of deep learning with genomics and artificial intelligence in drug discovery represents a transformative paradigm in biomedical research, offering unprecedented opportunities to accelerate scientific discovery and revolutionize healthcare. This…
preprints
2025
置信度 0.74
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ABSTRACT The immune system is an intricately evolved series of cellular and protein-protein interactions, which defend the body against pathogens and abnormal cells such as cancer. A key player in the immunologic recognition of non-self is the immune synapse, …
preprints
2025
置信度 0.74
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Language relies on a hierarchy of sensory and cognitive processes, yet how different levels of this hierarchy are supported by distinct neural architectures remains unclear. Here we show that semantic processing, compared with phonological processing, is assoc…
preprints
2026
置信度 0.74
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Abstract As one of the most well-studied cohesive subgraph models, the k-core is widely used to find graph nodes that are “central” or “important” in many applications, such as biological networks, social networks, ecological networks, and financial networks. …
preprints
2025
置信度 0.74
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Objective Biologically plausible learning rules for neural networks, such as e-prop (eligibility propagation), are essential both for advancing neuromorphic computing and for understanding fundamental mechanisms of learning in animal brains. However, their beh…
preprints
2025
置信度 0.74
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Reservoir computing is a neural network paradigm for processing temporal data by exploiting the dynamics of a fixed, high-dimensional system, enabling efficient computation with reduced complexity compared to fully trainable recurrent networks. This work prese…
preprints
2025
置信度 0.74
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Motivation RNA interference (RNAi) is a powerful tool for gene silencing across biological research, therapeutics, and agriculture. While siRNA design has benefited from advances in thermodynamic modeling and machine learning, comprehensive tools for designing…
preprints
2025
置信度 0.74
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Cortical microcircuits play a fundamental role in natural intelligence. While they inspired a wide range neural computation models and artificial intelligence algorithms, few attempts have been made to directly emulate them with an electronic computational sub…
preprints
2025
置信度 0.74
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Summary Prefix-free parsing [Boucher et al., Alg. Mol. Biol., 2019] is a highly effective heuristic for computing text indexes for very large amounts of biological data. The algorithm constructs a data structure, the prefix-free parse (PFP) of the input, consi…
preprints
2025
置信度 0.74
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Transcriptional regulation research, as a core area of life sciences, faces challenges such as scattered multi-omics data, complex joint analysis, and difficulties in integrating data processing tools. To address these issues, we propose TransAgent, an agent s…
preprints
2025
置信度 0.74
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Abstract Flavour perception is a complex and critical biological process in the food industry in general and in beer production in particular. Taste is influenced by the simultaneous interaction of a large number of molecules present in food and beverages with…
preprints
2025
置信度 0.74
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Determination of specimen structure from cryo-electron microscopy (cryo-EM) experiments relies on an accurate model of the electrostatic potential of the specimen. For biological macromolecules, the potential is strongly influenced by the presence of chemical …
preprints
2025
置信度 0.74
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Characterizing the minimum, necessary and sufficient components to generate the dynamics of a biological system has always been a priority to understand its functioning. In this sense, the canonical form of biological systems modeled by Boolean networks accura…
preprints
2025
置信度 0.74
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Topographic organization, whereby neighboring cortical locations encode neighboring features in sensory or cognitive space, is a fundamental principle of brain function. Existing approaches for obtaining individual-specific topographic maps either require reso…
preprints
2025
置信度 0.74
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Teaching BME 303 -Introduction to Computing, which covers programming languages such as C++ and Python, addresses the challenge of teaching foundational coding concepts while ensuring their applicability to biomedical engineering (BME).Recognizing that program…
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Ernesto Lima
2025-04-29T11:34:37Z
置信度 0.70
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Ndenga Lumbu Barack
2025-09-02T10:25:07Z
置信度 0.70
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To enhance the storage and analysis efficiency of large-scale data in molecular biology, a distributed database model accommodating diverse data types was developed, complemented by machine learning optimization algorithms for molecular sequence alignment, str…
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Zijian Zheng
2025-05-10T11:29:00Z
置信度 0.70
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Prediction of drug-target associations plays a crucial role in the process of drug development. However, traditional techniques for determining drug-target associations are labor-intensive, costly, and ineffective. Therefore, the development of effective and a…
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Sonia Lamba, Neetu Sardana
2025-12-31T18:41:12Z
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Foundation models are driving a paradigm shift across the life sciences, yet their transformative potential is fundamentally coupled to the capabilities of high-performance computing (HPC). The computational workloads presented by different biology and allied …
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Pratik Dutta, Tirthankar Ghosal
2025-11-07T16:13:44Z
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Climate change is intensifying environmental pollution, altering both pollutant distribution and the effectiveness of biological remediation strategies. Predicting pollution trends and designing adaptive remediation approaches are critical for sustainable ecos…
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Suresh K.S.
2025-11-19T05:54:56Z
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Shandar Ahmad, Dukka KC, Rudy Raymond
2025-12-30T08:28:40Z
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Inderscience is a global company, a dynamic leading independent journal publisher disseminates the latest research across the broad fields of science, engineering and technology; management, public and business administration; environment, ecological economics…
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Xin Dong, Xinyi Wang
2025-12-29T14:00:24Z
置信度 0.70
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In this paper, a Gabor detail feature-enhanced super-resolution network is constructed concerning the biological vision mechanism to address the problem on loss of texture detail information and contextual information in the process of medical image super-reso…
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Tao Fang, Linling Fang, Hao Pan
2025-10-16T03:43:59Z
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Maria Chiara Fiorentino, Selene Tomassini, Sara Moccia
2025-12-05T05:38:20Z
置信度 0.70
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Efforts to integrate living organisms in the design of new technolo- gies are often motivated by prospects of greater sustainability and increased connection with more-than-human worlds. In this paper, we critically discuss these motivations by analysing the v…
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Yuning Chen, Elise Cachat, Larissa Pschetz
2025-04-24T04:45:58Z
置信度 0.70
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Biological magnification is the process through which pollutants get amplified as they move up the food chain. This poses a significant environmental and health challenge. Traditional approaches to monitoring and controlling pollutants such as physical, chemic…
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Varinder Pabbi, Avinash Bhagat, Rishi Chopra
2025-08-21T18:17:57Z
置信度 0.70
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Recent advances in neuroimaging have enabled studies in functional connectivity (FC) of human brain, alongside investigation of the neuronal basis of cognition. One important FC study is the representation of vision in human brain. The release of publicly avai…
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Debanjali Bhattacharya, Neelam Sinha
2025-06-02T07:30:29Z
置信度 0.70
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This study presents a hybrid methodology that combines a novel fractional integral transform with the Fractional Differential Transform Method (FDTM) to solve fractional differential equations (FDEs). The proposed approach exploits the transform’s ability to h…
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Jayaram Prakash K, Saratha S R
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置信度 0.70
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Detection and classification of abnormalities in biological systems are critical tasks where early identification can significantly enhance intervention strategies and outcomes. Emerging technologies such as Deep Learning (DL) have opened new avenues for more …
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Chandra Babu J, Reddy Madhavi K
2025-07-01T10:48:17Z
置信度 0.70
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Nowadays, deep network-based classification algorithms are used in a myriad of applications for brain-computer interfaces (BCIs). These interfaces can enhance the daily lives of quadriplegic patients. Electroencephalography (EEG) based motor imagery (MI) is an…
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Prabhakar Agarwal, Sandeep Kumar, Rishav Singh
2025-08-21T01:18:49Z
置信度 0.70
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As population ages, there is an immense need to identify reliable biomarkers that reflect biological age, which is representative of the cumulative burden of physiological decline across all organ systems. The current model for estimating the systemic assessme…
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Pramath Kakodkar, Nooshin Shekari, Jay Kalra
2025-11-08T15:16:08Z
置信度 0.70
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Identifying disease-causing genes associated with genetic and rare diseases is crucial for understanding molecular mechanisms and advancing clinical treatments. Traditional experimental methods are time-consuming and labor-intensive. While various computationa…
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Xin Wang
2026-02-24T04:14:26Z
置信度 0.70
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In order to solve the dynamic job scheduling problem in current intelligent machining systems, the author proposes a multi-agent electromechanical production line dynamic scheduling based on iterative algorithms. The author designed a collaborative control met…
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Yan Zhang, Zipeng Li
2025-04-01T04:39:51Z
置信度 0.70
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Biological neuron signals are characterized by alternating action potentials (or spikes) and resting states. Action potentials are short-termed, high-amplitude peaks that consist of several successive phases, each reflecting specific electrophysiological proce…
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Karina Kurtova, Valeriy Ostrovskiy, Georgiy Kolev, Oleg Bayazitov 等
2025-07-08T13:36:13Z
置信度 0.70
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In lumbar total disc replacement, artificial disc implants are utilized to cure degenerative disc disease and restore natural motion. Human intervertebral discs (IVD) are part of the spine and contribute to delivering six degrees of freedom, elastic deformatio…
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Ashutosh Khanna, Pushpdant Jain, C. P. Paul
2025-05-10T04:45:34Z
置信度 0.70
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This work presents a hybrid framework combining Adaptive Resonance Theory (ART) clustering with deep neural network–based molecular restoration for efficient, target-specific drug optimization. Drug–protein pairs are first encoded into vector representations a…
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Sourav Singh Sehgal, Rahul Shrivastava, Trasha Bansal, Rohit Bansal
2026-03-26T19:47:30Z
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The combination of biotechnology and computer science gives a unique chance to develop the concept of intelligence and improve algorithms.This review aims to present the attempts made in this objective in an interdisciplinary manner, based on assembling concep…
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Athar Ahmed
2025-04-18T03:50:58Z
置信度 0.70
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Computational drug repositioning approaches should be investigated for the identification of new treatments for Alzheimer's patients as a huge amount of omics data has been produced during pre-clinical and clinical studies. Here, we investigated a gene network…
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Claudia Cava, Isabella Castiglioni
2025-02-17T21:26:24Z
置信度 0.70
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Photoacoustic tomography (PAT) has emerged as a promising imaging modality for breast cancer detection, offering unique advantages in visualizing tissue composition without ionizing radiation. However, limited-view scenarios in clinical settings present signif…
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Mary John, Imad Barhumi
2025-01-24T20:29:29Z
置信度 0.70
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In modern telehealth and healthcare information systems medical image analysis is essential to understand the context of the images and its complex structure from large, inconsistent-quality, and distributed datasets. Achieving desired results faces a few chal…
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Khalid Al-hammuri, Fayez Gebali, Awos Kanan
2025-02-18T05:27:35Z
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With the advancement of artificial intelligence technology, more and more effective methods are being used to identify and classify Electroencephalography (EEG) signals to address challenges in healthcare and brain-computer interface fields. The applications a…
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Hui Xiong, Yan Yan, Yimei Chen, Jinzhen Liu
2025-01-30T05:28:12Z
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Deep learning has revolutionized medical imaging, improving tasks like image segmentation, detection, and classification, often surpassing human accuracy. However, the training of effective diagnostic models is hindered by two major challenges: the need for la…
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Anirban Nath, Sneha Shukla, Puneet Gupta
2025-07-08T04:36:47Z
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The growing computational requirement of artificial intelligence (AI) mock-ups creates challenges in energy efficacy, scalability, and inactivity. Traditional AI architectures built on von Neumann structures and experience integral restrictions in imitating th…
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Aparna Sharma, Bhavesh Kumar Sharma, Shashi Bhushan, Vishvendra Pal Singh Nagar 等
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With the increase of age, the lower limb strength and function of the elderly gradually decline. Timely detection of motor dysfunction is of great significance for the prevention of disability, disease intervention, and improvement of living quality. Focusing …
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Lingling Chen, Ye Zheng, Zhuo Gong, Ding Wang
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Sophia Frangou, Dost Öngür
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Quantum computing represents a transformative shift in computational power, with the potential to revolutionize cryptography. This article examines the implications of quantum computing on current cryptographic algorithms, focusing on the vulnerabilities intro…
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Faisal Nadeem, Hira Waseem
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The emergence of quantum computing poses significant challenges and opportunities in the realm of cryptography. Traditional cryptographic algorithms, such as RSA and ECC (Elliptic Curve Cryptography), rely on the computational difficulty of certain mathematica…
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Noman Shakeel, Farah Batool
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Antibodies are a key therapeutic class in pharma, enabling precise targeting of disease agents. Traditional methods for their design are slow, costly, and limited. Advances in high-throughput data and artificial intelligence (AI) including machine learning, de…
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Soudabeh Kavousipour, Mahdi Barazesh, Shiva Mohammadi
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Detection of early mild cognitive impairment (EMCI) is clinically challenging as it involves subtle alterations in multiple brain sub-anatomic regions. Among different brain regions, the corpus callosum and lateral ventricles are primarily affected due to EMCI…
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Sreelakshmi Shaji, Rohini Palanisamy, Ramakrishnan Swaminathan
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Abstract This study aims to understand the impact of backpack carriage, a regular activity for many, on back muscles and joint mobility during walking so that clinicians can develop strategies or products to ensure individuals’ safety and well-being. Surface e…
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Fırat Matur, Fatma Alnamroush, Bora Büyüksaraç
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Convolutional neural networks (CNNs) have achieved remarkable success in computer vision, particularly in medical image segmentation. U-Net, a prominent architecture, marked a major breakthrough and remains widely used in practice. However, its uniform downsam…
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Xiaoxuan Ma, Sihan Shan, Dong Sui
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The threads of dental implants are critical components that transfer occlusal loads to the surrounding bone. The appropriate size of thread parameters can influence the stability of the implant after implantation. Despite several research studies on the effect…
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Masoud Arabbeiki, Mohammad Reza Niroomand
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Electroencephalography (EEG) is an important tool used to support the diagnosis and follow-up of neurological conditions, including epilepsy, sleep disorders, and neurodegenerative diseases such as Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Th…
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The generalization of deep learning (DL) models is critical for accurate lesion segmentation in breast ultrasound (BUS) images. Traditional DL models often struggle to generalize well due to the high frequency and scale variations inherent in BUS images. Moreo…
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Bilateral internal thoracic artery (BITA) grafting utilizes both the left (LITA) and right (RITA) internal thoracic arteries simultaneously and is recommended in the literature. However, the optimal configuration for BITA grafting remains uncertain. In this st…
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In order to address the increasing demand for vital sign detection, the author proposes a multi-target vital sign detection research that combines biological radar and convolutional neural network. Based on the fundamental architecture of convolutional neural …
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Erratum to: “Maternal Fiber Intake During Pregnancy and Development of Attention-Deficit/Hyperactivity Disorder Symptoms Across Childhood: The Norwegian Mother, Father, and Child Cohort Study,” by Solberg et al. (Biol Psychiatry 2024; 95:839–848); https://doi.…
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The authors have recognized errors in the reporting of participant numbers for the tic disorder diagnostic subgroups, affected by incorrect numbers pulled for the iPSYCH sample.This includes 4 subgroup values in the main Methods section and 5 subgroup values i…
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