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• Peripheral inflammation is associated with reduced influx of TSPO PET tracers into the brain: insights from a non-invasive mapping methodology
  Abstract Introduction Neuroinflammation is a hallmark of various brain disorders, including neuropsychiatric conditions like major depressive disorder and schizophrenia. Increasing evidence suggests that both peripheral and central inflammation play a critical…
  preprints 2025 置信度 0.74
• BundleAGE: Predicting White Matter Age using Along-Tract Microstructural Profiles from Diffusion MRI
  Brain Age Gap Estimation (BrainAGE) is an estimate of the gap between a person's chronological age (CA) and a measure of their brain's 'biological age' (BA). This metric is often used as a marker of accelerated aging, albeit with some caveats. Age prediction m…
  preprints 2024 置信度 0.74
• Haplotype-phased genomes of the barley leaf rust pathogen reveal evidence of repeat element expansion and somatic hybridization
  Barley leaf rust disease, caused by Puccinia hordei , leads to substantial yield losses and diminished malting quality of barley across temperate growing regions worldwide. To address the paucity of high-resolution genomic resources for this pathogen, we gener…
  preprints 2026 置信度 0.74
• Cognitive Flexibility and Brain Network Energy in Healthy Aging: an Allostatic Perspective from the SENECA model
  Understanding how the older adult brain sustains cognitive flexibility remains a central question in aging research. Here, we analyzed resting-state fMRI data from the population-based CamCAN database (N = 628; age 18–88) and applied structural balance theory …
  preprints 2025 置信度 0.74
• AnVILWorkflow: A runnable workflow package for Cloud-implemented bioinformatics analysis pipelines
  Abstract Advancements in sequencing technologies and the development of new data collection methods produce large volumes of biological data. The Genomic Data Science Analysis, Visualization, and Informatics Lab-space (AnVIL) provides a cloud-based platform fo…
  preprints 2024 置信度 0.74
• Exploiting Signal Propagation Delays to match Task Memory Requirements in Reservoir Computing
  Recurrent neural networks (RNNs) transmit information over time through recurrent connections. In contrast, biological neural networks use many other temporal processing mechanisms. One of these mechanisms is the inter-neuron delays caused by varying axon prop…
  preprints 2024 置信度 0.74
• MorphoCellSorter: An Andrews plot-based sorting approach to rank microglia according to their morphological features
  Microglia exhibit diverse morphologies reflecting environmental conditions, maturity or functional states. Thus, morphological characterization provides important information to understand microglial roles and functions. Most recent morphological analysis reli…
  preprints 2024 置信度 0.74
• scPRINT-2: Towards the next-generation of cell foundation models and benchmarks
  Cell biology has been booming with foundation models trained on large single-cell RNA-seq databases, but benchmarks and capabilities remain unclear. We propose an additive benchmark across a gymnasium of tasks to discover which features improve performance. Fr…
  preprints 2025 置信度 0.74
• Genetic association and machine learning improves discovery and prediction of type 1 diabetes
  Type 1 diabetes (T1D) has a large genetic component, and expanded genetic studies of T1D can lead to novel biological and therapeutic discovery and improved risk prediction. In this study, we performed genetic association and fine-mapping analyses in 817,718 E…
  preprints 2024 置信度 0.74
• Metabolomic ageing across mental and behavioural disorders
  Background Individuals with mental and behavioural disorders face increased risk of age-related diseases and premature mortality. Accelerated biological ageing may contribute to this disparity. We investigated differences in metabolomic ageing between individu…
  preprints 2025 置信度 0.74
• Coordinated shifts in gene expression and regulation during mole-rat evolution
  Changes in gene expression and regulation are central to mammalian phenotypic evolution. Yet, distinguishing adaptive gene expression shifts from neutral divergence remains challenging. Here, we integrate comparative transcriptomics and regulatory genomics to …
  preprints 2025 置信度 0.74
• Genetic liability to endometriosis and pregnancy outcomes: a two-sample Mendelian randomization study with maternal–fetal effect decomposition
  ABSTRACT Background Endometriosis is associated with adverse pregnancy outcomes in standard observational studies, including placental complications, preterm birth, and caesarean delivery. However, causal inference from these studies is complicated by residual…
  preprints 2026 置信度 0.74
• Genome dynamics across the radiation of a mega-diverse genus
  Summary Understanding the drivers of species diversity and rapid radiations is a major goal in evolutionary biology. Begonia is one of the most species-rich angiosperm genera with 2,164 species currently identified. This genus exhibits considerable variation i…
  preprints 2025 置信度 0.74
• Localization-dependent activation of the DEAD-box ATPase Vasa by eLOTUS domains
  ABSTRACT DEAD-box RNA helicases remodel RNA structures in many cellular pathways, yet how their activity is spatially controlled in cells remains poorly understood. The Drosophila germline helicase Vasa functions in ovaries only when localized to cytoplasmic g…
  preprints 2026 置信度 0.74
• Rapid gene exchange explains differences in bacterial pangenome structure
  The size and diversity of bacterial gene repertoires, known as pangenomes, vary widely across species. The evolutionary forces driving the maintenance of pangenomes is an open topic of debate, with contradictory theories suggesting that pangenomes exist as a r…
  preprints 2026 置信度 0.74
• Systematic analysis of immune cell motility leveraging Immunemap, an open intravital microscopy atlas
  Studying the spatiotemporal dynamics of cells in living organisms is a current frontier in bioimaging. Intravital Microscopy (IVM) provides direct, long-term observation of cell behavior in living animals, from tissue to sub-cellular resolution. Hence, IVM has…
  preprints 2024 置信度 0.74
• Adaptation to marginal habitats provides resilience to future warming at the rear edge
  Rear-edge populations, relicts of glacial refugia, often persist in marginal habitats at the warmer edge of species distributions. Persistence in these habitats likely required adapting to postglacial climate warming. The resulting local adaptation may affect …
  preprints 2026 置信度 0.74
• APPROACHES TO DIMENSIONALITY REDUCTION FOR ULTRA-HIGH DIMENSIONAL MODELS
  ABSTRACT The rapid advancement of high-throughput sequencing technologies has revolutionised genomic research by providing access to large amounts of genomic data. However, the most important disadvantage of using Whole Genome Sequencing (WGS) data is its stat…
  preprints 2024 置信度 0.74
• Lateralised modulation of posterior alpha oscillations by closed loop auditory stimulation during memory retention
  Alpha oscillations have been implicated in the maintenance of working memory representations. Notably, when memorised content is spatially lateralised, the power of posterior alpha activity exhibits corresponding lateralisation during the retention interval, c…
  preprints 2025 置信度 0.74
• C-COMPASS: A Neural Network Tool for Multi-Omic Classification of Cell Compartments
  Functional compartmentalization in eukaryotic cells is essential for maintaining physiological processes. The development of systematic organelle proteomic techniques, such as Protein Correlation Profiling (PCP) and Localization of Organelle Proteins by Isotop…
  preprints 2024 置信度 0.74
• Quantifying the contribution of genetic variation to healthcare expenditure across diverse healthcare systems
  Healthcare systems must balance rising costs with the delivery of effective care, yet the factors underlying large inter-individual differences in healthcare expenditure remain incompletely understood. Here we examine how genome-wide genetic variation contribu…
  preprints 2026 置信度 0.74
• Open Benchmarking for Cell-Based Multiscale Models: Lessons from a Community Initiative
  The emergence of virtual human twins (VHT) in biomedical research has sparked interest in multiscale in silico modelling frameworks, particularly in their application bridging cellular to tissue levels. Among the diverse array of multiscale modelling tools, of…
  preprints 2025 置信度 0.74
• The iPhylo Suite: An Interactive Platform for Building and Annotating Biological and Chemical Taxonomic Trees
  Accurate and rapid taxonomic classifications are essential for systematically exploring organisms and metabolites in diverse environments. Many tools have been developed for biological taxonomic trees, but limitations apply, and a streamlined method for constr…
  preprints 2024 置信度 0.74
• Optimising the use of Oxford nanopore sequencing technology for detection of <i>Wolbachia</i> bacterial endosymbionts in <i>Anopheles</i> mosquitoes
  Malaria, a mosquito-borne disease predominantly affecting sub-Saharan Africa, remains a significant global health challenge with 263 million cases in 2023. Although progress in vaccine development has recently occurred, insecticide resistance has reduced the e…
  preprints 2025 置信度 0.74
• Boltz-2: Towards Accurate and Efficient Binding Affinity Prediction
  Accurately modeling biomolecular interactions is a central challenge in modern biology. While recent advances, such as AlphaFold3 and Boltz-1, have substantially improved our ability to predict biomolecular complex structures, these models still fall short in …
  preprints 2025 置信度 0.74
• Quantifying higher-order epistasis: beware the chimera
  Epistasis, or interactions in which alleles at one locus modify the fitness effects of alleles at other loci, plays a fundamental role in genetics, protein evolution, and many other areas of biology. Epistasis is typically quantified by computing the deviation…
  preprints 2024 置信度 0.74
• Placing very long branch taxa in the plant tree of life: a case study with Dioscoreales mycoheterotrophs
  Premise The inclusion of heterotrophic plants in broadly focused systematic studies is challenging, reflecting substantial morphological modification, gene loss, and accelerated nucleotide substitution following photosynthesis loss. In particular, inclusion of…
  preprints 2025 置信度 0.74
• Physical Reservoir Computing Enabled by Solitary Waves and Biologically-Inspired Nonlinear Transformation of Input Data
  Reservoir computing (RC) systems can efficiently forecast chaotic time series using nonlinear dynamical properties of an artificial neural network of random connections. The versatility of RC systems has motivated further research on both hardware counterparts…
  preprints 2024 置信度 0.74
• Three cortical streams for somatosensory information processing
  Abstract The somatosensory cortex processes information hierarchically, transforming sensory input into appropriate responses. This hierarchy, in turn, provides a fundamental principle for the organization of anatomical and functional properties across the som…
  preprints 2025 置信度 0.74
• A curated reference dataset and deep learning model for multi-lead electrocardiographic interval measurements in UK Biobank
  Electrocardiographic (ECG) interval measurements underpin clinical decision-making and large-scale cardiovascular research, yet existing automated methods are often developed using small, heterogeneous datasets with limited expert annotation and uncertain gene…
  preprints 2026 置信度 0.74
• Genetic designs for stochastic and probabilistic biocomputing
  The programming of computations in living cells can be done by manipulating information flows within genetic networks. Typically, a single bit of information is encoded by a single gene’s steady state expression. Expression is discretized into high and low lev…
  preprints 2024 置信度 0.74
• Self-supervised learning for a gene program-centric view of cell states
  Single-cell omics has extended the biological interrogation of cell state from examining the expression of individual genes to unbiased profiling of tens of thousands of genes at once. However, extracting biological insights from such high-dimensional data rem…
  preprints 2026 置信度 0.74
• SuperCell2.0 enables semi-supervised construction of multimodal metacell atlases
  Multimodal single-cell atlases comprising hundreds of thousands of cells provide unique resources for exploring complex biological tissues and generating testable hypotheses. To streamline the analysis of such large datasets, we introduce SuperCell2.0, a robus…
  preprints 2026 置信度 0.74
• Language laterality and cognitive skills: does anatomy matter?
  Brain anatomy, particularly white matter microstructure, is thought to play a critical role in the relationships between cognitive function and language lateralisation. This study investigates whether white matter microstructural parameters of the arcuate fasc…
  preprints 2025 置信度 0.74
• Genome-Wide Insights into the Genes and Pathways Shaping Human Foveal Development
  Here we report the first genome-wide association study of foveal pit depth. In a cohort of 61,269 individuals, we identified 123 genome-wide significant loci associated with pit depth, including 47 novel associations not previously linked to macular traits. Us…
  preprints 2025 置信度 0.74
• Multidomain determinants of perivascular spaces indicate early cerebrovascular vulnerability in individuals at risk of Alzheimer’s disease
  Background Perivascular spaces (PVS) are increasingly recognized as MRI-visible markers of cerebrovascular and glymphatic functions. However, the determinants of regional PVS burden in the preclinical stages of Alzheimer’s disease (AD) remain to be elucidated,…
  preprints 2026 置信度 0.74
• Stable and dynamic gene expression patterns over diurnal and developmental timescales in <i>Arabidopsis thaliana</i>
  Summary Developmental processes are known to be circadian regulated in plants. For instance, the circadian clock regulates genes involved in the photoperiodic flowering pathway and the initiation of leaf senescence. Furthermore, signals which entrain the circa…
  preprints 2024 置信度 0.74
• From Variability to Synchrony: Non-linear Development of Auditory Neural Responses During the First Year of Life
  In humans, the first year of life is characterized by rapid developmental changes, including substantial brain maturation. As a result, neural responses to auditory stimuli undergo marked changes during this period. In this study, we followed 69 infants across…
  preprints 2026 置信度 0.74
• Differential Targeting of the Nucleosome Surface and Superhelical Crevice Sites with Ru and Os Organometallic Agents
  ABSTRACT Platinum anticancer drugs tend to target DNA whereas certain ruthenium and osmium organometallic compounds, including those with known anticancer activity, preferentially bind histone proteins in chromatin. We earlier found that Ru/Os arene 2-pyridine…
  preprints 2025 置信度 0.74
• Pattern recognition using spiking antiferromagnetic neurons
  Abstract Spintronic devices offer a promising avenue for the development of nanoscale, energy-efficient artificial neurons for neuromorphic computing. It has previously been shown that with antiferromagnetic (AFM) oscillators, ultra-fast spiking artificial neu…
  preprints 2024 置信度 0.74
• A Distributed Computing Solution for Privacy-Preserving Genome-Wide Association Studies
  Breakthroughs in sequencing technologies led to an exponential growth of genomic data, providing unprecedented biological in-sights and new therapeutic applications. However, analyzing such large amounts of sensitive data raises key concerns regarding data pri…
  preprints 2024 置信度 0.74
• The role of rare copy number variants in early-onset depression
  Background Depression is a highly heterogeneous condition. Depression with an onset in childhood and early adolescence has a worse clinical course, is more heritable, and shows a lower genetic correlation with other depression subtypes, than does later-onset d…
  preprints 2025 置信度 0.74
• Application of Quantum Tensor Networks for Protein Classification
  Computational methods in drug discovery significantly reduce both time and experimental costs. Nonetheless, certain computational tasks in drug discovery can be daunting with classical computing techniques which can be potentially overcome using quantum comput…
  preprints 2024 置信度 0.74
• Effectiveness and efficiency: label-aware hierarchical subgraph learning for protein-protein interaction
  Protein-protein interactions (PPIs) are crucial in various biological processes and their study has significant implications for drug development and disease diagnosis. Existing deep learning methods for PPIs prediction, including graph neural networks (GNNs),…
  preprints 2024 置信度 0.74
• From sample to insight: Onsite training and implementing mobile environmental surveillance in sub-Saharan Africa
  Environmental surveillance for human pathogen detection is crucial for safeguarding public health; however, traditional approaches are often time-consuming, equipment-intensive and workflow-complex, delaying actionable public-health decision-making. The integr…
  preprints 2026 置信度 0.74
• Exodermis lignification impacts lateral root emergence in <i>Brachypodium distachyon</i>
  Summary Rationale The mechanisms controlling lateral root emergence in monocots, particularly the role of the exodermis, are poorly understood. We investigated how natural variation in the Brachypodium distachyon stress response shapes root system architecture…
  preprints 2025 置信度 0.74
• Functional Control of Network Dynamical Systems: An Information Theoretic Approach
  In neurological networks, the emergence of various causal interactions and information flows among nodes is governed by the structural connectivity in conjunction with the node dynamics. The information flow describes the direction and the magnitude of an exci…
  preprints 2024 置信度 0.74
• A high-quality reference genome and comparative genomics of the widely-farmed banded cricket ( <i>Gryllodes sigillatus</i> ) identifies selective breeding targets
  Farmed insects have gained attention as an alternative, sustainable source of protein with a lower carbon footprint than traditional livestock. We present a high-quality reference genome for one of the most commonly farmed insects, the banded cricket Gryllodes…
  preprints 2025 置信度 0.74
• Estimating severity and rate of change of depressive symptoms in adolescence: a comparison of functional principal component analysis and mixed effects models
  ABSTRACT Understanding depressive symptoms dynamics and their determinants is crucial for designing effective mental health support initiatives. This study compared two methods for describing youth depressive symptoms trajectories and investigated associations…
  preprints 2026 置信度 0.74
• PlantCV v4: Image analysis software for high-throughput plant phenotyping
  ABSTRACT PlantCV is an open-source Python project aimed at developing tools to address a range of image-based, plant phenotyping questions. PlantCV has been used for more than 10 years to automate trait collection from image data and the newest release, PlantC…
  preprints 2025 置信度 0.74
• RECUR: Identifying recurrent amino acid substitutions from multiple sequence alignments
  Identifying recurrent changes in biological sequences is important to multiple aspects of biological research -from understanding the molecular basis of convergent phenotypes, to pinpointing the causative sequence changes that give rise to antibiotic resistanc…
  preprints 2025 置信度 0.74
• Analog Implementation of a Spiking Neuron with Memristive Synapses for Deep Learning Processing
  Analog neuromorphic prototyping is crucial for creating spiking neuron models that use memristive devices as synapses to design integrated circuits that leverage on-chip parallel deep neural networks. These models mimic how biological neurons in the brain comm…
  preprints 2024 置信度 0.74
• Cryo-EM image processing of amyloid filaments in RELION-5.1
  We present new tools for the structure determination of amyloid filaments from electron cryo-microscopy (cryo-EM) images. We introduce a new algorithm for automated filament picking, based on their characteristic 4.75 Å repeat signal; we implement the new auto…
  preprints 2026 置信度 0.74
• UFMylation anchors splicing factors at the ER to reprogram nuclear splicing
  How organelles communicate stress to the nucleus to coordinate adaptive responses remains a fundamental question in cell biology. Here, we identify a non-canonical retrograde signaling pathway in which stalling-induced UFMylation of ER-associated ribosomes anc…
  preprints 2026 置信度 0.74
• Weighted sliced inverse regression for scalable supervised dimensionality reduction of spatial transcriptomics data
  With the dramatic take-up of spatially resolved transcriptomics biotechnologies, performing spatially-aware analysis of the resulting data is crucial to maximise advances in biological understanding. Dimensionality reduction is a first step in almost any analy…
  preprints 2025 置信度 0.74
• A subject-specific reversible folding model reveals geometry-driven white-matter organization
  Tractography currently relies almost exclusively on diffusion data and seed maps, which alone remain insufficient for anatomically accurate fiber reconstruction. During brain development, white-matter fibers elongate alongside cortical folding, suggesting a cl…
  preprints 2025 置信度 0.74
• SQ-KFP: A Framework for Spatially Quantitative Metabolic Flux Analysis Enables Imaging the &lt;i&gt;In Vivo&lt;/i&gt; Absolute Metabolic Enzymatic Reaction Rate.
  Alterations in metabolite concentrations often serve as direct drivers of phenotypic variation or disease onset. The changes in metabolite concentrations are directly dependent on the enzymatic reaction rates. However, spatially resolved imaging of the absolut…
  europepmc 2026 置信度 0.80
• RNAsolo 2.0: multimodal database to study RNAs, their structural families and intermolecular interfaces.
  Understanding RNA structures - essential for uncovering their biological functions, interactions, and therapeutic potential - relies on both experimental techniques and computational approaches increasingly driven by artificial intelligence. The latter are tra…
  europepmc 2026 置信度 0.80
• PathwayEmbed: a computational tool to quantify intracellular signaling transduction states from transcriptomic data.
  Motivation Intracellular signaling pathways regulate essential cellular functions and orchestrate complex biological processes, yet their dynamic activity remains challenging to quantify with precision. Advances in single-cell omics enable pathway activity inf…
  europepmc 2026 置信度 0.80
• Organic Phototransistor Photonic Synapses for Artificial Vision.
  The von Neumann architecture faces significant limitations, including low transmission efficiency and high energy consumption, when handling large-scale data and unstructured problems. Benefiting from the inherent merits of optical signals including high bandw…
  europepmc 2026 置信度 0.80
• copick: An open dataset interface and toolkit for collaborative annotation and analysis of cryo-electron tomography data.
  Cryo-electron tomography (cryoET) enables visualization of macromolecular complexes within intact cellular environments. Continued improvements in instrumentation, sample preparation, and data-processing pipelines have increased both the scale and the complexi…
  europepmc 2026 置信度 0.80
• Dynamics of attractor transitions in Boolean networks under noise.
  Biological systems operate under persistent noise, which can alter system states and induce transitions between attractors. Here, we study the attractor dynamics of Boolean networks focusing on the transitions between attractors induced by noise. By computing …
  europepmc 2026 置信度 0.80
• Algebraic Invariants for Inferring 4-Leaf Semi-Directed Phylogenetic Networks.
  A core goal of phylogenomics is to determine the evolutionary history of a set of species from biological sequence data. Phylogenetic networks are able to describe more complex evolutionary phenomena than phylogenetic trees but are more difficult to accurately…
  europepmc 2026 置信度 0.80
• An Analogue Memristor Based on Conjugated Porous Polymer Composite for Artificial Synapse.
  Artificial synapses have emerged as a pivotal technological advancement in mimicking brain functions. Organic memristors are desirable for hardware implementation of artificial synapses, owing to their remarkable mechanical flexibility, high biocompatibility a…
  europepmc 2026 置信度 0.80
• Halide Perovskites for Neuromorphic Sensing and Computing.
  The development of semiconductor-based electronic devices has significantly advanced sensor-based data acquisition and processor-driven data analysis. However, conventional complementary metal-oxide-semiconductor technologies are now facing fundamental limitat…
  europepmc 2025 置信度 0.80
• Research progress of artificial intelligence in high-throughput drug screening.
  High-throughput screening (HTS) is widely used in modern drug discovery. It enables batch activity testing of compounds and provides important support for the identification of active compounds. However, its screening efficiency and accuracy need to be improve…
  europepmc 2026 置信度 0.80
• Predicting protein-protein interaction sites based on dynamic perception mechanism within a hierarchical E(n)-equivariant graph.
  Accurate prediction of protein-protein interaction sites is crucial to understanding biological processes, elucidating disease mechanisms, and accelerating drug discovery. Although graph neural network methods have shown potential in this field, but existing m…
  pubmed Li X, Qiao S, Li Z, Zhou S 等 2026 置信度 0.82
• Interface-engineered Gd₂O₃/ZrO₂ bilayer memristor for emulating synaptic plasticity in neuromorphic systems.
  Rare-earth-based materials are attracting growing interest for neuromorphic devices due to their unique electronic structures, defect engineering capabilities, and high ionic mobility, which enable energy-efficient and highly controllable memristive switching …
  europepmc 2026 置信度 0.80
• Association of Sweetened Beverages with Risk of Osteoporosis and First Fractures: Evidence from the United Kingdom Biobank.
  We investigated the associations between intake of sugar-sweetened, artificially sweetened, and naturally sweetened beverages (SSBs, ASBs, and NSBs) and osteoporosis and first incident fracture risks. We analyzed data from 171,694 to 168,366 United Kingdom Bio…
  pubmed Youn JE, Kwon YJ, Lee YJ, Han TH 等 2026 置信度 0.82
• Rethinking bioinformatics expertise in the era of artificial intelligence.
  Artificial intelligence (AI) is often framed as replacing scientific expertise, especially in bioinformatics. We argue instead that AI is a powerful accelerant whose value depends on expert guidance in design, data curation, interpretation, and governance. Bec…
  pubmed Wen Bin Goh W, Polster A, Wong L, Cvijovic M 2026 置信度 0.82
• In silico development microsatellite marker panel and characterization for the endangered neotropical species Brycon orbignyanus (Characiformes, Bryconidae): a short communication.
  This short communication presents novel molecular tools designed for the endangered species Brycon orbignyanus. In conservation studies, the development of population-specific markers tailored to particular geographic regions is essential. In this study, the p…
  europepmc 2026 置信度 0.80
• Oxide Semiconductor Thin-Film Transistors for Low-Power Electronics.
  Low power consumption has become an essential criterion in the development of next-generation electronics, driven by the growing adoption of Internet of Things, wearables, and portable platforms. Oxide semiconductor thin-film transistors (TFTs) have become mos…
  europepmc 2026 置信度 0.80
• High-Level Environmental Sustainability Guidelines for Large Accelerator Facilities.
  The proposed construction of new particle accelerator-based facilities in the coming decades-and upgrades to existing facilities-provides the unique opportunity to embed innovative environmental impact reduction techniques into their design. This living docume…
  europepmc 2026 置信度 0.80
• On learning functions over biological sequence space: relating Gaussian process priors, regularization, and gauge fixing.
  Mappings from biological sequences (DNA, RNA, protein) to quantitative measures of sequence functionality play an important role in contemporary biology. We are interested in the related tasks of (i) inferring predictive sequence-to-function maps and (ii) deco…
  europepmc 2026 置信度 0.80
• Highly biased DNA sequence reconstruction in DNA storage with multi-scale attention mechanism and contrast learning.
  Base substitution, insertion, and deletion errors due to inherent technical constraints inducing unavoidable sequencing inaccuracies, limiting access to high-quality raw data and biological knowledge. To address this, we propose a deep sequence reconstruction …
  europepmc 2026 置信度 0.80
• Synaptic Plasticity Engineering for Neural Precision, Temporal Learning, and Scalable Neuromorphic Systems.
  Manipulating the expression of synaptic plasticity in neuromorphic devices provides essential foundations for developing intelligent, adaptive hardware systems. In recent years, advances have shifted from static emulation toward dynamic, network-oriented plast…
  europepmc 2026 置信度 0.80
• PLM-eXplain: divide and conquer the protein embedding space.
  Motivation Protein language models (PLMs) have revolutionized computational biology through their ability to generate powerful sequence representations for diverse prediction tasks. However, their black-box nature limits biological interpretation and translati…
  europepmc 2026 置信度 0.80
• Population health management fit lifecycles in analytics.
  Introduction "Population Health Management (PHM), Fit Lifecycles in Analytics" examines the policy and practice of AI-driven methodologies to enhance public health and patient safety in the context of the Human Phenotype Ontology (HPO). It aims for personalize…
  europepmc 2025 置信度 0.80
• Yomix: an interactive tool for the exploration of low-dimensional embeddings in omics data.
  Summary In the analysis of diverse omics data, a common and important preliminary step involves computing low-dimensional embeddings using techniques such as PCA, UMAP, t-SNE, or variational autoencoders. These embeddings provide a global overview of sample di…
  europepmc 2026 置信度 0.80
• Advanced Design for High-Performance and AI Chips.
  Recent years have witnessed transformative changes brought about by artificial intelligence (AI) techniques with billions of parameters for the realization of high accuracy, proposing high demand for the advanced and AI chip to solve these AI tasks efficiently…
  europepmc 2025 置信度 0.80
• Essential nucleic acid omics: a theoretical foundation for early-stage users.
  Modern biology often relies on the analysis of entire sets of molecules (omics). A subset of omics uses nucleic acid sequencing to reconstruct genomes and profile gene expression. Novel findings and existing data are contextualized by databases, which have bee…
  europepmc 2025 置信度 0.80
• Overcoming Volatility in Ion Gel via Ag Doping for Nonvolatile Memristive Switching.
  Ion-gel-based memory devices can effectively change their resistance states even at low voltages, owing to the rapid mobility of ions and the formation of an electric double layer. However, their volatile characteristics limit their use in nonvolatile memory a…
  europepmc 2026 置信度 0.80
• Self-Rectifying Memristors for Beyond-CMOS Computing: Mechanisms, Materials, and Integration Prospects.
  The deceleration of Moore's law and the energy-latency drawbacks of the von Neumann bottleneck have heightened the pursuit for beyond‑CMOS designs that integrate memory and compute. Self‑rectifying memristors (SRMs) have emerged as promising building blocks fo…
  europepmc 2026 置信度 0.80
• Microelectrode Arrays Technology for Brain-on-a-Chip Applications.
  Brain-on-a-chip (BOC) refers to a miniaturized in vitro platform that integrates living neuronal networks on a micro-engineered chip, enabling the simulation of brain functions, neural activities and physiological responses. BOC technology is an advanced evolu…
  europepmc 2026 置信度 0.80
• Empirical Logic for Bio-Inspired Soft Computing: Illustrative Applications in Control Engineering and Cluster Analysis.
  Empirical logic (EL) is a bio-inspired soft computing approach to rule-based decision-making that emphasizes intuitive, experience-based reasoning. While its theoretical foundations have been established in previous work, its practical applicability and access…
  europepmc 2026 置信度 0.80
• Heterosynaptic Memtransistors Based on Switching Operation Mechanism Using Designed Organic/Inorganic Heterostructures for Neuromorphic Electronics.
  Memtransistors using low-dimensional semiconductors represent a promising gate-tunable heterosynaptic architecture for neuromorphic computing. However, active layers of these devices have not yet been artificially designed or controlled. In this study, gate-pu…
  europepmc 2026 置信度 0.80
• Harnessing glycol-alkyl copolymerization to realize nonvolatile and biologically relevant synaptic behaviors.
  Organic electrochemical synaptic transistors (OESTs) are attracting growing attention for neuromorphic computing, yet their long-term stability remains constrained by uncontrolled ion dynamics. Previous studies have incorporated glycol side chains to facilitat…
  europepmc 2026 置信度 0.80
• FastSCODE: an accelerated SCODE algorithm for inferring gene regulatory networks on manycore processors.
  Summary SCODE reconstructs gene regulatory networks from single-cell RNA sequencing (scRNA-seq) data using an ordinary differential equation (ODE) model, and has been successfully applied to a wide range of scRNA-seq datasets, including mouse, human, and plant…
  europepmc 2025 置信度 0.80
• Cryo-EM: the revolution continues.
  The near-universal adoption of electron cryo-microscopy (cryo-EM) by structural and cell biologists has led to exponential growth of the field, especially over the last two decades, with a doubling in the number of deposited electron-microscopy density maps ev…
  europepmc 2026 置信度 0.80
• Atlas-level single-cell integration and clustering-free differential expression analysis with GEDI 2.0.
  Motivation GEDI is a generative framework for multi-sample, multi-condition single-cell analysis that performs batch correction, latent representation learning, and clustering-free differential expression within a unified model. However, the original implement…
  europepmc 2026 置信度 0.80
• Can neuromorphic computing help reduce AI's high energy cost?
  Artificial intelligence systems, and large language models (LLMs) in particular, have become almost ubiquitous.The implications are many.Among them: serious concerns about massive amounts of energy usage.The initial training of GPT-3 required as much energy as…
  europepmc 2025 置信度 0.80
• New Frontiers in AI-Nano Converged Platforms for Intelligent Diagnostics, Therapeutics, and Safety Evaluation.
  The complexity of nanomedicine poses a significant challenge to traditional empirical methods. Machine learning (ML), with its ability to parse high-dimensional data and predict nonlinear interactions, is empowering AI nano fusion platforms, driving innovation…
  europepmc 2026 置信度 0.80
• GPU-accelerated modeling of biological regulatory networks.
  The complex regulatory dynamics of biological networks can be succinctly captured using discrete logic models. Previous work has shown that global optimization schemes are well suited for finding state transition logic and kinetic model parameters, in what are…
  europepmc 2026 置信度 0.80
• Super-resolution microscopy: revolutionizing life sciences through advanced resolution.
  With the rapid revolution in super-resolution microscopy, the resolution of far-field optical microscopy has entered the sub-nanometer era, providing new insights into macromolecules in vitro and in situ .
  europepmc 2026 置信度 0.80
• MEGA 12.1: Cross-Platform Release for macOS and Linux Operating Systems.
  The Molecular Evolutionary Genetics Analysis (MEGA) software is widely used for molecular evolutionary and phylogenetic analyses. We present MEGA version 12.1, a cross-platform release that operates natively on macOS (Intel and Apple M-series processors) and m…
  europepmc 2026 置信度 0.80
• Mapping educational needs in bioinformatics in Brazil: adapting ISCB 3.0 competencies to a regional context.
  Motivation Bioinformatics drives modern biological discovery, and Brazil has become an important contributor to genomics and computational biology. However, bioinformatics education across the country struggles to meet diverse regional and professional demands…
  europepmc 2025 置信度 0.80
• Trends and Prospects of Biometrics: From Sensing to Perception and Cognition.
  Biometrics technology is undergoing a paradigm shift from static single-modal authentication to continuous multimodal sensing, combined with higher-performing algorithms powered by new deep learning techniques. This editorial reviews cutting-edge advancements …
  europepmc 2026 置信度 0.80
• ONYX: an alignment-free biological sex inference from high-throughput sequencing data.
  Biological sex inference from genomic data is important in population genomics, conservation biology, and forensic science, yet many existing approaches depend on sequence alignment or species-specific markers and may therefore be limited in their transferabil…
  europepmc 2026 置信度 0.80
• Know your scientist: KYC as biosecurity infrastructure.
  Biological AI tools for protein design and structure prediction are advancing rapidly, creating dual-use risks that existing safeguards cannot adequately address. Current model-level restrictions, including keyword filtering, output screening, and content-base…
  europepmc 2026 置信度 0.80
• Harnessing interpretable deep learning to predict resistance in &lt;i&gt;Klebsiella pneumoniae&lt;/i&gt;.
  Introduction Antimicrobial resistance poses a growing global health threat, complicating therapeutic management and increasing morbidity and mortality. Deep learning methods have emerged as effective tools for bacterial profiling using omics data, particularly…
  europepmc 2026 置信度 0.80