生物计算 · 全部实体（第 50 / 100 页）

本页收录第 4901–5000 条，共 10000 条 · 返回 生物计算 首页

• Comparative Analysis of Single-Nucleus and Single-Cell RNA Sequencing in Human Bone Marrow Mononuclear Cells: Methodological Insights and Trade-offs
  Bone marrow mononuclear cells (BMMCs) are a heterogeneous pool of hematopoietic progenitors and mature immune cells that collectively sustain hematopoiesis and coordinate immune responses. The bone marrow serves not only as the primary site for blood cell prod…
  preprints 2025 置信度 0.74
• Benchmarking GROMACS on Optimized Colab Processors and the Flexibility of Cloud Computing for Molecular Dynamics
  M olecular d ynamics (MD) simulations are widely used computational tools in chemical and biological sciences. For these simulations, GROMACS is a popular open-source alternative among molecular dynamics simulation software designed for biochemical molecules. …
  preprints 2024 置信度 0.74
• Combining new interventions with urban development as a path to effective, consistent, and durable control of dengue
  Dengue is a mosquito-transmitted viral disease that has long defied control but now has a growing list of promising interventions becoming available. Major investments in these interventions are being made without a clear picture of the long-term implications …
  preprints 2026 置信度 0.74
• Behavioral Time Scale Synaptic Plasticity (BTSP) endows binding of distributed representations with flexible retrieval options
  Human reasoning depends on reusing pieces of information by binding them together in new ways, thereby “making infinite uses of finite means” (Alexander von Humboldt). Needed for that is a binding mechanism that enables fast composition and decomposition of to…
  preprints 2025 置信度 0.74
• Magnetic Ion Modulation (MIM) Theory: A Novel Approach to Controlling Ion Behavior via Magnetic Fields in Biological and Non-Biological Systems
  e Magnetic Ion Modulation (MIM) Theory presents a unified and groundbreaking mathematical framework for controlling and predicting ion behavior in both biological and non-biological systems using external magnetic fields. Central to the theory is the **Ion Mod…
  preprints 2024 置信度 0.74
• Recent cloud trends and extremes reaffirm moderate climate sensitivity
  Abstract Earth's energy imbalance exhibits a robust positive trend over the past two decades, reaching a record value in 2023. Both the trend and year-to-year anomalies are primarily attributable to decreased reflection of sunlight by low-level clouds, which i…
  preprints 2025 置信度 0.74
• Drought and overwintering fires drive consecutive large fire seasons in boreal North America
  Abstract Boreal North America experienced unprecedented consecutive extreme fire seasons during 2023–2025, marked by record-breaking burned area and emissions. We identify a series of interconnected mechanisms that enabled these back-to-back extremes. A multi-…
  preprints 2026 置信度 0.74
• PlantScience.ai: An LLM-Powered Virtual Scientist for Plant Science
  The accelerating growth of plant science literature presents a major challenge for researchers seeking to extract accurate, up-to-date knowledge from an increasingly fragmented and domain-specific corpus. General-purpose large language models (LLMs), while pow…
  preprints 2025 置信度 0.74
• General Theory of Information and Self-Managing Secure Services on the Internet
  The Internet provides an endless supply of information, enables communication, collaboration, and commerce at a global scale, and supports businesses large and small with platforms for e-commerce, remote work, and digital marketing. On the other hand, our priv…
  preprints 2024 置信度 0.74
• Integrating temporal genomic and transcriptomic analyses to decipher genetic basis of feed intake in dairy cattle
  Background Food intake is a complex trait in living organisms, where the genetics of food intake have been widely studied in humans, mice, Drosophila, cattle, pigs, chicken, and fish. In dairy cattle, intake of feed is highly linked to individuals’ energy bala…
  preprints 2026 置信度 0.74
• Neuromorphic Photonic On-chip Computing
  Drawing inspiration from biological brain's energy-efficient information-processing mechanisms, photonic integrated circuits (PIC) have facilitated the development of ultrafast artificial neural networks. This in turn is envisaged to offer potential solut…
  preprints 2024 置信度 0.74
• Lifespan-extending downregulation of insulin signalling reduces germline mutation load
  Reduced insulin/IGF-1 signalling (IIS) robustly extends lifespan and enhances somatic stress resistance across taxa, yet its consequences for germline genome integrity remain unclear. Here we combine multigenerational mutation accumulation with whole-genome se…
  preprints 2025 置信度 0.74
• Identifying and replicating plasma proteins associated with hypertrophic cardiomyopathy severity in carriers of pathogenic <i>MYBPC3</i> variants
  Background Hypertrophic cardiomyopathy (HCM) is a clinically variable disease in terms of onset and progression. Pathogenic MYBPC3 variants account for a substantial proportion of HCM diagnoses. This study sought to identify protein biomarkers associated with …
  preprints 2026 置信度 0.74
• End of Average. Understanding Overweight &amp; Obesity: Rationale and Design
  Abstract Background : Obesity is globally recognized as a complex, multifactorial chronic disease, with biological, psychological, environmental and behavioural factors involved in both disease pathogenesis and maintenance. Although previous group-based studie…
  preprints 2026 置信度 0.74
• Panalyze: automated virus pangenome variation graph construction, analysis and annotation
  Motivation Constructing and studying pangenome variation graphs (PVG) supports new insights into viral genomic diversity. This is because such pangenomes are less prone to reference bias, which affects mutation detection. Interpreting the information arising f…
  preprints 2025 置信度 0.74
• A haplotype-complete chromosome-level assembly of octoploid Urochloa humidicola cv. Tully reveals multiple genomic compositions and evolutionary histories in the species
  We developed a haplotype-resolved, chromosome-scale genome assembly of the Urochloa humidicola (Rendle) Morrone & Zuloaga cultivar Tully, an apomictic C4 forage grass cultivated in the tropics worldwide. We assembled a 4.1 Gb genome into 48 chromosomes (2n = 8…
  preprints 2025 置信度 0.74
• iPRSue: Unbiased individual-level uncertainty estimation in polygenic risk scores
  Abstract Advancements in genomic analytics continue to improve the accuracy and clinical relevance of polygenic risk scores (PRSs). While quantifying uncertainty in individual PRS estimates is essential for clinical decision-making, existing tools offer limite…
  preprints 2026 置信度 0.74
• <i>In Silico</i> Optimisation of Regenerative Cell Therapy in the Infarcted Human Ventricles to Mitigate Arrhythmic Burden
  Myocardial infarction remains a frequent cause of heart failure and mortality. Cell therapy has been shown promising in pre-clinical trials to regenerate the damaged tissue, but delivered cells may beat spontaneously and produce arrhythmias in the ventricles, …
  preprints 2025 置信度 0.74
• Standardized transcriptome analysis improves rare disease diagnosis in the pan-European Solve-RD consortium
  RNA sequencing (RNA-seq) provides a powerful complement to DNA sequencing for uncovering pathogenic defects affecting gene expression and splicing in individuals with genetically undiagnosed rare disorders. However, as large rare disease consortia adopt RNA-se…
  preprints 2026 置信度 0.74
• Common genetic determinants of dynamic human in vivo immune response to <i>Mycobacterium tuberculosis</i>
  We investigated host-genetic TB susceptibility by expression quantitative trait loci (eQTL) analysis of the tuberculin skin test (TST) as a standardised challenge model of human in vivo TB immunology. Paired genotyping with 415 RNA-sequencing profiles from day…
  preprints 2026 置信度 0.74
• From shared genes to staged decay: ecosystem-specific genomic potential for litter decomposition in soils
  Abstract Plant litter decomposition governs how much carbon soils store and emit, yet the microbial traits that shape ecosystem-scale decay remain unresolved. Metagenomes can quantify genes encoding plant cell-wall-degrading enzymes, but it is unclear whether …
  preprints 2026 置信度 0.74
• Dynamic Multiday Seizure Cycles and Evolving Rhythms in a Tetanus Toxin Rat Model of Epilepsy
  Epilepsy is characterized by recurrent, unpredictable seizures that impose significant challenges in daily management and treatment. One emerging area of interest is the identification of seizure cycles, including multiday patterns, which may offer insights in…
  preprints 2024 置信度 0.74
• Protein-protein interactions drive differences in the spatiotemporal dynamics of transcription factors NANOG and SOX2 in naïve pluripotent cells
  Maintenance of naïve pluripotency requires core transcription factors (TFs) like SOX2 and auxiliary TFs like NANOG, yet molecular mechanisms governing their intra-nuclear dynamics and DNA binding interactions remain unclear. Here, using high-density 3D single-…
  preprints 2025 置信度 0.74
• Using human genetic variation to estimate the effect of lipoprotein(a) lowering on pregnancy outcomes
  Background Lipoprotein(a) (Lp[a]) is a genetically determined causal and independent cardiovascular risk factor and Lp(a) targeted therapies are being developed. However, evidence on the safety of substantial Lp(a) lowering during pregnancy is limited. We eval…
  preprints 2026 置信度 0.74
• Paying Attention to Attention: High Attention Sites as Indicators of Protein Family and Function in Language Models
  Protein Language Models (PLMs) use transformer architectures to capture patterns within protein sequences, providing a powerful computational representation of the protein sequence [1]. Through large-scale training on protein sequence data, PLMs generate vecto…
  preprints 2024 置信度 0.74
• Network-based disease fingerprinting with neuroinflammation PET imaging
  Abstract Neuroinflammation is a hallmark of numerous neurodegenerative, psychiatric, and chronic pain disorders and can be assessed in vivo with 18 kDa translocator protein (TSPO) positron emission tomography (PET). However, conventional quantification methods…
  preprints 2025 置信度 0.74
• Proton Pump Inhibitor Omeprazole Alters the Spiking Characteristics of Proteinoids
  Abstract This study reveals the significant effect of the proton pump inhibitor omeprazole on the spiking behaviour of proteinoids, leading to a transformative shift in the field of unconventional computing. Through the application of different concentrations …
  preprints 2024 置信度 0.74
• A flexible quality metric for electrophysiological recordings across brain regions and species
  The increasing size of electrophysiological datasets has heightened the need for quality metrics that automatically reject neurons whose activity was recorded with low sensitivity or specificity. One key approach estimates artifactual contamination by assuming…
  preprints 2026 置信度 0.74
• Design of Memristor Based Modified Synapse Circuit for Low-Power Neuromorphic Computing
  Abstract It is high time that brain-inspired or neuromorphic computing must have enough concentration to grow and overcome the computational barrier, which will mimic the biological neuron cell, and its computational abilities will be applied from the neurosci…
  preprints 2024 置信度 0.74
• Oxidative Stress Susceptibility, Complement Dysregulation, and Metabolic Reprogramming in CFH Y402H Patient-Derived Choriocapillaris Endothelial Cells
  Abstract Age-related macular degeneration (AMD) is a leading cause of central vision loss. Immunofluorescence and gene expression studies in human donor eyes have shown that choriocapillaris endothelial cells (CECs) are lost before retinal pigment epithelium (…
  preprints 2026 置信度 0.74
• A high-quality reference genome and tissue expression atlas for the European lobster ( <i>Homarus gammarus</i> )
  The European lobster ( Homarus gammarus ) and its sister species, the American lobster ( Homarus americanus ), are notable for their remarkable immunity and longevity, with lifespans reaching up to 80 years in the wild. A reference genome is available for the …
  preprints 2025 置信度 0.74
• Atypical energy-related symptoms define biologically distinct subtypes of major depressive disorder
  ABSTRACT Major depressive disorder (MDD) is a complex psychiatric disorder, characterized by a range of mood, cognitive, and neurovegetative symptoms. Current diagnostic criteria treat opposite symptom directions as equivalent; weight gain or loss, and increas…
  preprints 2026 置信度 0.74
• Long-term morphometric similarity gradients relate to cortical hierarchy and psychiatric symptoms in schizophrenia
  Schizophrenia spectrum disorders (SSD) are characterized by altered brain structure, reflecting widespread dysconnectivity across brain-specific networks. However, the role of hierarchical organization on cortical morphometric networks in shaping clinical outc…
  preprints 2026 置信度 0.74
• Low-dimensional brain-symptom associations delineate depression phenotypes with distinct connectivity biomarkers and symptom profiles
  Depression is neurobiologically and clinically heterogeneous. New approaches using resting-state functional MRI (rs-fMRI) functional connectivity (FC) data have modeled the neural basis of depression heterogeneity and revealed unique neural phenotypes. Yet, no…
  preprints 2025 置信度 0.74
• AnVILWorkflow: A runnable workflow package for Cloud-implemented bioinformatics analysis pipelines
  Advancements in sequencing technologies and the development of new data collection methods produce large volumes of biological data. The Genomic Data Science Analysis, Visualization, and Informatics Lab-space (AnVIL) provides a cloud-based platform for democra…
  preprints 2024 置信度 0.74
• Brain structure-function coupling – relationship with language lateralisation
  Language is one of the most extensively studied lateralised cognitive functions in the human brain, predominantly relying on the left hemisphere in most individuals. However, the mechanisms by which a stable white matter architecture underpins individual langu…
  preprints 2025 置信度 0.74
• Cytochrome ‘Nanowires’ are Physically Limited to Sub-Picoamp Currents that Suffice for Cellular Respiration
  Mineral-respiring microorganisms from hydrothermal vents to terrestrial soils express filaments that electrically connect intracellular respiration to extracellular geochemistry. Filaments dubbed “cytochrome nanowires” (CNs) have been resolved by CryoEM, but w…
  preprints 2024 置信度 0.74
• Blood-based proteomic signatures of spontaneous menopause: Implications for later-life brain aging and Alzheimer’s disease risk
  Abstract Menopause is a hallmark process in biological aging that has been associated with later life neurodegenerative risk. We leveraged proteomics data from multiple cohorts (N>3,000) to identify biological changes underlying menopause and its links to brai…
  preprints 2026 置信度 0.74
• Probabilistic Photonic Computing with Chaotic Light
  Abstract Biological neural networks effortlessly tackle complex computational problems and excel at predicting outcomes from noisy, incomplete data, a task that poses significant challenges to traditional processors. Artificial neural networks (ANNs), inspired…
  preprints 2024 置信度 0.74
• Temporal Gating by Chandelier Cells Encodes Signed Prediction Errors
  Abstract The brain refines its predictions of the world by updating its internal model whenever sensory input differs from expectation. The sign of this prediction error matters: an unexpected event signals that the model under-predicted (positive error), whil…
  preprints 2026 置信度 0.74
• Rapid value learning reveals generalized and context-dependent codes in frontal cortex
  Abstract Studying how the brain represents value spans distinct methods and training histories, from neuroimaging in task-naïve humans to single-neuron recordings in extensively trained non-human primates. Similar findings across fields have encouraged the unt…
  preprints 2026 置信度 0.74
• An improved <i>Solanum verrucosum</i> genome provides insight into potato centromeres and epigenetic regulation
  Solanum verrucosum is a wild diploid potato species notable for carrying the uncharacterised Rpi-ver1 gene conferring resistance to Phytophthora infestans , possessing unusually structured centromeres, and exhibiting the rare trait of self-compatibility, the g…
  preprints 2025 置信度 0.74
• AlphaFold Database expands to proteome-scale quaternary structures
  Protein function is governed by molecular interactions, yet structural coverage of these interactions remains sparse. The AlphaFold Protein Structure Database (AFDB) transformed access to accurate monomeric protein structures at scale. Here, we expand the AFDB…
  preprints 2026 置信度 0.74
• The Hidden Biology of Wellbeing: A Multi-Omics Analysis Across Genomic, Epigenomic, and Transcriptomic Layers
  Biological systems are composed of multiple molecular layers, including the genome, epigenome, transcriptome, and metabolome. These layers are interconnected and interact, but are often studied independently. Multi-omics approaches aim to integrate these layer…
  preprints 2025 置信度 0.74
• Poplar: A Phylogenetics Pipeline
  Motivation Generating phylogenetic trees from genomic data is essential in understanding biological systems. Each step of this complex process has received extensive attention in the literature, and has been significantly streamlined over the years. Given the …
  preprints 2024 置信度 0.74
• Classical and Quantum Physical Reservoir Computing for Onboard Artificial Intelligence Systems: A Perspective
  Artificial intelligence (AI) systems of autonomous systems such as drones, robots and self-driving cars may consume up to 50% of total power available onboard, thereby limiting the vehicle’s range of functions and considerably reducing the distance the vehicle…
  preprints 2024 置信度 0.74
• Large-Scale Structure-Based Virtual Screening Identifies Diverse K _Na 1.1 (KCNT1) Potassium Channel Inhibitors
  Severe drug-resistant childhood epilepsy is caused by KCNT1 gain-of-function genetic variants, resulting in increased K Na 1.1 channel activity. KCNT1 -associated epilepsy is thought to affect around 1 in 300,000 births worldwide. Current treatment for KCNT1 e…
  preprints 2025 置信度 0.74
• Exploring the Interface of Microwave Technology, Quantum Computing and Neuroscience
  Microwave technology, foundational in quantum computing, utilizes precise control of quantum states via microwave pulses to manage quantum bits (qubits). This review explores the potential of leveraging these principles in neuroscience, where such technology c…
  preprints 2024 置信度 0.74
• Living Bacterial Reservoir Computers for Information Processing and Sensing
  We introduce a systems-level approach to sensing and computing in which Escherichia coli acts as a living reservoir computer, performing complex information processing through its native growth responses without requiring genetic modification or specialized in…
  preprints 2024 置信度 0.74
• ­­­A novel quantum algorithm for Biological Sequence Alignment using Quantum Accelerated Mapping in Seed-and-Extend Technique.
  Abstract A novel quantum algorithm for use in Biological Sequence Alignment is presented and analyzed. The large amounts of data extracted from genome sequencing, de novo assembly sequencing, resequencing, and transcriptome sequencing at the DNA or RNA level, …
  preprints 2024 置信度 0.74
• AnnSQL: A Python SQL-based package for fast large-scale single-cell genomics analysis using minimal computational resources
  As single-cell genomics technologies continue to accelerate biological discovery, software tools that use elegant syntax and minimal computational resources to analyze atlas-scale datasets are increasingly needed. Here we introduce AnnSQL, a Python package tha…
  preprints 2024 置信度 0.74
• Early-childhood temperament deviations mark psychiatric risk into early adulthood
  Early-childhood temperament is associated with mental health outcomes decades later. Temperament reflects early-emerging individual differences in emotional and behavioral tendencies. These differences are relatively stable across development and shaped by bot…
  preprints 2026 置信度 0.74
• General Theory of Information: The Bridge to Mindful Machines
  General Theory of Information (GTI) offers a groundbreaking framework for designing mindful machines that bridge the divide between biological intelligence and digital automation. GTI reimagines traditional computing by introducing cognitive, autopoietic (self…
  preprints 2024 置信度 0.74
• Integration of diverse bioactivity data into the Chemical Checker compound universe
  Chemical signatures encode the physicochemical and structural properties of small molecules into numerical descriptors, forming the basis for chemical comparisons and search algorithms. The increasing availability of bioactivity data has improved compound repr…
  preprints 2024 置信度 0.74
• Simple Dynamic Visualization of Memristor-Based Synaptic Plasticity in a Simulated Neural Network
  This article presents a novel computational approach to visualizing memristor dynamics within a simulated neural network. Memristors, known for their ability to emulate synaptic plasticity due to their variable resistance characteristics, are key components in…
  preprints 2024 置信度 0.74
• GraFusionNet: Integrating Node, Edge, and Semantic Features for Enhanced Graph Representations
  ABSTRACT Understanding complex graph-structured data is a cornerstone of modern research in fields like cheminformatics and bioinformatics, where molecules and biological systems are naturally represented as graphs. However, traditional graph neural networks (…
  preprints 2024 置信度 0.74
• Lipid-facilitated opening of the ADAM10 sheddase revealed by enhanced sampling simulations
  ADAM10 is a crucial membrane-bound metalloprotease that regulates cellular physiology by cleaving and releasing membrane-anchored proteins, including adhesion molecules and growth factor precursors, thereby modulating cell signaling, adhesion, and migration. D…
  preprints 2025 置信度 0.74
• Farmer Managed Natural Regeneration Promotes Expansion of Trees on Croplands in the Sahel
  Abstract The expansion of trees on croplands in the Sahel has been promoted as a nature-based solution to climate challenges, particularly through Farmer Managed Natural Regeneration (FMNR). Yet large-scale assessments of cropland tree dynamics remain scarce. …
  preprints 2025 置信度 0.74
• Robust metabolomics data normalization across scales and experimental designs
  Metabolomics studies employing liquid chromatography-mass spectrometry are affected by signal drift and batch effects, introducing technical variance that impedes biological knowledge discovery. Quality control (QC) sample-based normalization strategies are wi…
  preprints 2025 置信度 0.74
• Efficient Working Memory Maintenance via High-Dimensional Rotational Dynamics
  Working memory (WM) is fundamental to higher-order cognition, yet the circuit mechanisms through which memoranda are maintained in neural activity after removal of sensory input remain subject to vigorous debate. Prominent theories propose that stimuli are enc…
  preprints 2025 置信度 0.74
• Rapid degradation of 6 class I HDAC complexes reveals minimal functional overlap between complexes
  The class 1 HDACs 1, 2 and 3 form seven families of distinct large multiprotein complexes that regulate gene expression via deacetylation of lysines in histone tails. The degree of redundancy and functional overlap between complexes and their primary gene targ…
  preprints 2025 置信度 0.74
• Modeling neuron-astrocyte interactions in neural networks using distributed simulation
  Astrocytes engage in local interactions with neurons, synapses, other glial cell types, and the vasculature through intricate cellular and molecular processes, playing an important role in brain information processing, plasticity, cognition, and behavior. This…
  preprints 2024 置信度 0.74
• Getting over ANOVA: Estimation graphics for multi-group comparisons
  Data analysis in experimental science mainly relies on null-hypothesis significance testing, despite its well-known limitations. A powerful alternative is estimation statistics, which focuses on effect-size quantification. However, current estimation tools str…
  preprints 2026 置信度 0.74
• The combined use of scRNA-seq and network propagation highlights key features of pan-cancer Tumor-Infiltrating T cells
  Improving the selectivity and effectiveness of drugs represents a crucial issue for future therapeutic developments in immuno-oncology. Traditional bulk transcriptomics faces limitations in this context for the early phase of target discovery as resulting gene…
  preprints 2024 置信度 0.74
• Multichannel meta-imager for parallel front-end optical computations
  Abstract Optical computing has demonstrated significant advantages over electronic computing, including parallelism, high-speed processing, extensive capacity, and low energy consumption. Optical computing front ends leveraging metasurfaces provide advantages …
  preprints 2024 置信度 0.74
• Towards foundation models that learn across biological scales
  We have reached a point where many bio foundation models exist across 4 different scales, from molecules to molecular chains, cells, and tissues. However, while related in many ways, these models do not yet bridge these scales. We present a framework and archi…
  preprints 2025 置信度 0.74
• Evolutionarily conserved transcriptional regulators control monoaminergic neuron development
  To what extent conserved developmental programs specify homologous cell types is a central question in biology. Here, we address this by focusing on reconstructing monoaminergic neuron development in Drosophila melanogaster embryo using time- resolved single-c…
  preprints 2025 置信度 0.74
• R2G2: A Python-R Framework for Seamless Integration of R/Bioconductor Tools into Galaxy
  ABSTRACT R is widely used in statistical computing, data analysis, and bioinformatics. A key contributor to its success in bioinformatics and computational biology is the open-source project Bioconductor. As of its latest release (3.20), the Bioconductor commu…
  preprints 2025 置信度 0.74
• The GLUT4 storage vesicle pool is maintained by intracellular nanovesicle traffic
  Glucose transporter 4 (GLUT4) is sequestered intracellularly until the action of insulin causes its redistribution to the cell surface. How cells sequester GLUT4, generating and maintaining GLUT4 storage vesicles (GSVs), is still unclear. Intracellular nanoves…
  preprints 2026 置信度 0.74
• Stochasticity in mammalian cell growth rates drives cell-to-cell variability independently of cell size and divisions
  Cell growth rates exhibit cell-intrinsic cell-to-cell variability, which influences cell fitness and size home-ostasis from bacteria to cancer. Whether this variability arises from noise in cell growth or cell division processes, or originates from cell-size-d…
  preprints 2025 置信度 0.74
• Membrane binding of a cyanobacterial ESCRT-III protein crucially involves the helix α1-3 hairpin conserved in all superfamily members
  IM30, the inner membrane-associated protein of 30 kDa (also known as Vipp1) is essential for thylakoid membrane biogenesis and/or maintenance in chloroplasts and cyanobacteria. IM30 and its bacterial homolog PspA belong to the ESCRT-III superfamily, proteins p…
  preprints 2025 置信度 0.74
• Pathway Polygenic Risk Scores (pPRS) for the Analysis of Gene-environment Interaction
  A polygenic risk score (PRS) is used to quantify the combined disease risk of many genetic variants. For complex human traits there is interest in determining whether the PRS modifies, i.e. interacts with, important environmental (E) risk factors. Detection of…
  preprints 2024 置信度 0.74
• G2PDeep-v2: a web-based deep-learning framework for phenotype prediction and biomarker discovery using multi-omics data
  The G2PDeep-v2 server is a web-based platform powered by deep learning, for phenotype prediction and markers discovery from multi-omics data in any organisms including humans, plants, animals, and viruses. The server provides multiple services for researchers …
  preprints 2024 置信度 0.74
• Ultrack: pushing the limits of cell tracking across biological scales
  Tracking live cells across 2D, 3D, and multi-channel time-lapse recordings is crucial for understanding tissue-scale biological processes. Despite advancements in imaging technology, achieving accurate cell tracking remains challenging, particularly in complex…
  preprints 2024 置信度 0.74
• Mispitools: An R package for comprehensive statistical methods in Kinship Inference
  The search for missing persons is a complex process that involves the comparison of data from two entities: unidentified persons (UP), who may be alive or deceased, and missing persons (MP), whose whereabouts are unknown. Although existing tools support DNA-ba…
  preprints 2024 置信度 0.74
• Structure-Function Dynamics in Healthy Cognitive Aging: A Graph Signal Processing Approach
  Network neuroscience has significantly advanced our understanding of how structural and functional connectivity evolve during healthy neurocognitive aging. Yet, integrative studies linking structural and functional brain organization with cognitive performance…
  preprints 2025 置信度 0.74
• Determination of nucleotide-nucleotide and nucleotide-amino acid binding interactions from all-atom potential-of-mean-force calculations
  Biomolecular condensates emerge from multivalent interactions between proteins and nucleic acids and are frequently modeled using coarse-grained molecular dynamics simulations. The parametrization of these models critically depends on atomistic data describing…
  preprints 2025 置信度 0.74
• Reference-free clustering as an epidemiological tool for <i>Mycobacterium tuberculosis</i> lineage typing
  ABSTRACT Whole-genome sequencing (WGS) of Mycobacterium tuberculosis (Mtb) is widely used in the epidemiological investigation of recent transmission events, resulting in high-resolution strain typing. Accurate and rapid strain typing is essential for informin…
  preprints 2026 置信度 0.74
• TOMOMAN: a software package for large scale cryo-electron tomography data preprocessing, community data sharing, and collaborative computing
  Cryo-electron tomography (cryo-ET) and subtomogram averaging (STA) are becoming the preferred methodologies for investigating subcellular and macromolecular structures in native or near-native environments. While cryo-ET is amenable to a wide range of biologic…
  preprints 2024 置信度 0.74
• The frequency and importance of polyploidy in tropical rainforest tree radiations
  Summary The presence of two or more copies of the genome in an organism, termed ‘polyploidy’, is a crucial force in plant evolution, generating genetic, phenotypic and ecological diversity. The Amazonian tree flora is the most species-rich on Earth, and largel…
  preprints 2025 置信度 0.74
• A canary in the mind: A single baseline brain scan predicts adolescent depression and anxiety one year later
  Mood and anxiety disorders emerge predominantly in adolescence, yet they are usually identified only once symptoms have consolidated, when intervention can only be reactive. A marker that registers the loss of healthy brain function before symptoms crystallise…
  preprints 2026 置信度 0.74
• A flexible pipeline for reproducible exome-wide rare variant gene-trait associations
  Summary Exome-wide gene-burden association studies are widely used to assess gene – trait relationships. By focusing on coding variants, such analyses can directly quantify the magnitude and direction of a gene’s effect on a given trait across the proteome, in…
  preprints 2025 置信度 0.74
• Computing hematopoietic stem and progenitor cell plasticity in response to genetic mutations and environmental stimulations
  Cell plasticity (CP), describing a dynamic cell state, plays a crucial role in maintaining homeostasis during organ morphogenesis, regeneration and damage-to-repair biological process. Single-cell-omics datasets provide unprecedented resource to empowers analy…
  preprints 2024 置信度 0.74
• Cosine Similarity Estimation Using FracMinHash: Theoretical Analysis, Safety Conditions, and Implementation
  Motivation The increasing number and volume of genomic and metagenomic data necessitates scalable and robust computational models for precise analysis. Sketching techniques utilizing k -mers from a biological sample have proven to be useful for large-scale ana…
  preprints 2024 置信度 0.74
• Temporal Information Encoding in Isolated Cortical Networks
  Time-dependent features are present in many sensory stimuli. In the sensory cortices, timing features of stimuli are represented by spatial as well as temporal code. A potential mechanism by which cortical neuronal networks perform temporal-to-spatial conversi…
  preprints 2024 置信度 0.74
• Mammalian MemPrep establishes the lipid composition of ER membranes in HEK293T cells
  The endoplasmic reticulum (ER) forms a dynamic network of sheets and tubules, whose molecular lipid composition remains incompletely defined. Using an optimized MemPrep workflow, we establish a high-confidence lipidome of the mammalian ER and selectively enric…
  preprints 2026 置信度 0.74
• CytoVI: Deep generative modeling of antibody-based single cell technologies
  Due to their robustness, dynamic range and scalability, antibody-based single cell technologies, such as flow cytometry, mass cytometry and CITE-seq, have become an irreplaceable part of routine clinics and a powerful tool for basic research. However, their an…
  preprints 2025 置信度 0.74
• PICASO: Profiling Integrative Communities of Aggregated Single-cell Omics data
  Various single-cell modalities covering transcriptomics, epigenetic and spatio-temporal changes in health and disease phenotypes are used in an exploratory way to understand biological systems at single-cell resolution. However, the vast amount of such single-…
  preprints 2024 置信度 0.74
• Cell position is the primary determinant of cell identity in the uniseriate filament of the brown alga Ectocarpus
  The brown alga Ectocarpus is a morphologically simple organism, with cells in the growing filament changing shape and position over time. In this study, we investigated the roles of cell shape, position, and age in establishing cell identity in Ectocarpus. Usi…
  preprints 2026 置信度 0.74
• A mechanistic theory of planning in prefrontal cortex
  Planning is critical for adaptive behaviour in a changing world, because it lets us anticipate the future and adjust our actions accordingly. While prefrontal cortex is crucial for this process, it remains unknown how planning is implemented in neural circuits…
  preprints 2025 置信度 0.74
• Applicability Assessment of Technologies for Predictive and Prescriptive Analytics of Nephrology Big Data
  The integration of big data into nephrology research has opened new avenues for analyzing and understanding complex biological datasets, driving advancements in personalized management of cardiovascular and kidney diseases. This paper explores the multifaceted…
  preprints 2024 置信度 0.74
• Analog reservoir computing via ferroelectric mixed phase boundary transistors
  Analog reservoir computing (ARC) systems have attracted attention owing to their efficiency in processing temporal information. However, the distinct functionalities of the system components pose challenges for hardware implementation. Herein, we report a full…
  openalex Jangsaeng Kim, Eun Chan Park, Wonjun Shin, Ryun‐Han Koo 等 2024-10-23 置信度 0.72 FerroelectricityTransistorBoundary (topology)Phase (matter)Phase boundary
• European Neuroendocrine Tumor Society (ENETS) 2024 guidance paper for the management of well‐differentiated small intestine neuroendocrine tumours
  Both the incidence and prevalence of well-differentiated neuroendocrine tumours from the small intestine (Si-NET) are gradually increasing. Most patients have non-functioning tumours with subtle GI symptoms and tumours are often discovered incidentally by endo…
  openalex Ángela Lamarca, Detlef K. Bartsch, Martyn Caplin, Beata Kos‐Kudła 等 2024-07-08 置信度 0.72 Neuroendocrine tumourNeuroendocrine tumorsSmall intestineInternal medicineMedicine
• A Nanotechnology-Ready Computing Scheme based on a Weakly Coupled Oscillator Network
  With conventional transistor technologies reaching their limits, alternative computing schemes based on novel technologies are currently gaining considerable interest. Notably, promising computing approaches have proposed to leverage the complex dynamics emerg…
  openalex Damir Vodenicarevic, Nicolas Locatelli, Flavio Abreu Araujo, Julie Grollier 等 2017-03-21 置信度 0.72 ScalabilityLeverage (statistics)Computer scienceDistributed computingComputation
• Effect of tokenization on transformers for biological sequences
  MOTIVATION: Deep-learning models are transforming biological research, including many bioinformatics and comparative genomics algorithms, such as sequence alignments, phylogenetic tree inference, and automatic classification of protein functions. Among these d…
  openalex Edo Dotan, Gal Jaschek, Tal Pupko, Yonatan Belinkov 2024-03-29 置信度 0.72 Lexical analysisComputer scienceArtificial intelligenceNatural language processingBiological network
• PigBiobank: a valuable resource for understanding genetic and biological mechanisms of diverse complex traits in pigs
  To fully unlock the potential of pigs as both agricultural species for animal-based protein food and biomedical models for human biology and disease, a comprehensive understanding of molecular and cellular mechanisms underlying various complex phenotypes in pi…
  openalex Haonan Zeng, Wenjing Zhang, Qing Lin, Yahui Gao 等 2023-10-27 置信度 0.72 BiologyResource (disambiguation)Evolutionary biologyGenetic resourcesGenetics
• Choosing the Right Biologic for the Right Patient With Severe Asthma
  In this installment of the How I Do It series on severe asthma, we tackle the clinical conundrum of choosing the right biologic for the right patient with severe asthma. With six biologics now approved for use in this area comprising four different targeting s…
  openalex Simon Couillard, David J. Jackson, Ian Pavord, Michael E. Wechsler 2024-09-06 置信度 0.72 AsthmaMedicineRight to healthPolitical scienceInternal medicine
• BIDCell: Biologically-informed self-supervised learning for segmentation of subcellular spatial transcriptomics data
  Recent advances in subcellular imaging transcriptomics platforms have enabled high-resolution spatial mapping of gene expression, while also introducing significant analytical challenges in accurately identifying cells and assigning transcripts. Existing metho…
  openalex Xiaohang Fu, Yingxin Lin, David Lin, Daniel Mechtersheimer 等 2024-01-13 置信度 0.72 Computer scienceSegmentationTranscriptomeArtificial intelligenceCell type
• The Computable City
  How computers simulate cities and how they are also being embedded in cities, changing our behavior and the way in which cities evolve. At every stage in the history of computers and communications, it is safe to say we have been unable to predict what happens…
  openalex Michael Batty 2024-02-27 置信度 0.72 Computer science
• A hybrid quantum computing pipeline for real world drug discovery
  Quantum computing, with its superior computational capabilities compared to classical approaches, holds the potential to revolutionize numerous scientific domains, including pharmaceuticals. However, the application of quantum computing for drug discovery has …
  openalex Weitang Li, Zhi Yin, Xiaoran Li, Dongqiang Ma 等 2024-07-23 置信度 0.72 Computer scienceQuantum computerDrug discoveryPipeline (software)Quantum