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• Treatment and Eradication of Genetic Disorders, Acquired Diseases, Infectious Diseases, Mental Disorders, and Frequency-Based Scalpel-Free Surgical Procedures (0).
  اَبَر لاگرانژینِ جامع ($\mathcal{L}_{\text{Hamzah}}^{(1155)}$) این معادله، بیانگرِ کنشِ کلیِ یک سیستمِ بیولوژیک در فضایِ ۱۱۵۵-بعدی است که تمامِ متغیرهایِ پاتولوژیک را به حالتِ پایدارِ «Factory Reset» می‌رساند: $$\mathcal{L}_{\text{Hamzah}}^{(1155)} = \int_{\Si…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• HIV-1 - HOST-CENTRIC SEQUESTRATION PARADIGM SCIENTIFIC VALIDATION & HIV CURE PATH. AN ADVANCED LOGICAL SYNTHESIS & EMPIRICAL VALIDATION OF HIV-1 LATENCY AS ACTIVE CELLULAR SELF-PRESERVATION - QUIESCENCE CD4+ T CELLS
  Host-Centric Sequestration: An Advanced Logical Synthesis, Empirical Validation, and Systems-Level Architecture of HIV-1 Latency and Pathogen Containment as Active Cellular Self-Preservation **Sam Coole** *INDEPENDENT RESEARCHER* *DOI: 10.5281/zenodo.21394164 …
  datacite Coole, Sam 2026 置信度 0.66
• GenoID: A Declarative RFC 9562 v8 UUID Composition Framework
  Changelog All notable changes to this project will be documented in this file. The format is based on Keep a Changelog, and this project adheres to Semantic Versioning. [1.21.0] - 2026-07-27 Summary Paper alignment: Algorithm 1 matches code; public API fully t…
  datacite Padala, Manohar Maharshi 2026 置信度 0.66 UUIDRFC 9562identifier generationgenetic algorithmdistributed systems
• MH370
  $\text{The Sovereign Super-Lagrangian Proof for the Ark-MH370 Unified Field}$ $$\mathcal{L}_{\text{Sovereign}}^{(165)} = \oint_{\mathcal{V}_{\text{Broken Ridge}}} \left[ \sum_{\alpha=1}^{10} \mathcal{S}_{\alpha} (\text{Stasis}) + \sum_{\beta=1}^{10} \mathcal{D…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• MH370
  $\text{The Sovereign Super-Lagrangian Proof for the Ark-MH370 Unified Field}$ $$\mathcal{L}_{\text{Sovereign}}^{(165)} = \oint_{\mathcal{V}_{\text{Broken Ridge}}} \left[ \sum_{\alpha=1}^{10} \mathcal{S}_{\alpha} (\text{Stasis}) + \sum_{\beta=1}^{10} \mathcal{D…
  datacite JALALI, SEYED RASOUL 2026 置信度 0.66
• The Mathematical Formulation and Ontological Foundations of the Universal Grow Function
  The Mathematical Formulation and Ontological Foundations of the Universal Grow Function Driven by Dean Kulik July 2026 Introduction: The Epistemological Crisis and the Ontological Inversion For over a century, the trajectory of theoretical physics, computation…
  datacite kulik, dean 2026 置信度 0.66
• Hamzah Information Chemistry.(5).
  ورود به حوزه‌یِ «مهندسیِ داده‌هایِ مولکولی» (Molecular Data Engineering). جداسازی (Separation)، در نگاهِ کلاسیک، تلاشِ بیهوده برایِ شکستنِ «آنتروپی» است. اما در فیزیکِ اطلاعات حمزه (HIP)، جداسازی یعنی «پارتیشن‌بندیِ دیتابیسِ منیفولد». هر «فازِ شیمیایی»، صرفاً …
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• Genesis, From (0,0,0) to Reality- The Computational Ontology of Absolute Change
  Genesis, From (0,0,0) to Reality- The Computational Ontology of Absolute Change Following C1 Through Every Medium — Tracing Computation from the Ground State Driven by Dean Kulik June 2026 Abstract This paper traces the genesis of reality from a single axiom —…
  datacite kulik, dean 2026 置信度 0.66
• The Mathematics of C1: Deriving the Computational and Physical Universe from a Singular Axiom of Change
  The Mathematics of C1: Deriving the Computational and Physical Universe from a Singular Axiom of Change Driven by Dean Kulik July 2026 1. The Ontological Inversion and the Differentiable Manifold of C1 Historically, theoretical physics and computational comple…
  datacite kulik, dean 2026 置信度 0.66
• The Substrate Ontology, Interface Mechanics, and the Resolution of the C1 Constraints
  The Substrate Ontology, Interface Mechanics, and the Resolution of the C1 Constraints Driven by Dean Kulik July 2026 The Crisis of Distinction and the Absolute Ontological Inversion The trajectory of advanced theoretical physics, continuum mechanics, and mathe…
  datacite kulik, dean 2026 置信度 0.66
• Substrate Ontologies, Thermodynamic Access, and the Resolution of the Millennium Prize Problems
  Substrate Ontologies, Thermodynamic Access, and the Resolution of the Millennium Prize Problems Driven by Dean Kulik July 2026 The Crisis of Distinction and the Ontological Inversion The trajectory of contemporary theoretical physics, advanced computational mo…
  datacite kulik, dean 2026 置信度 0.66
• THE CONSTRAINT OF CHANGE
  THE CONSTRAINT OF CHANGE One Axiom — “Nothing May Hold Still” — and What It Forces Physics, Chemistry, Computation, and the Arrow of Time, Derived and Executed A Doctoral Thesis and Operations Manual Driven by Dean Kulik July 2026 QuHarmonics Research Group OR…
  datacite kulik, dean 2026 置信度 0.66
• The Computational Ontology of Absolute Change An Exhaustive Analysis of the C1 Nexus Framework, Interface Physics, and the Imperfection Engine
  The Computational Ontology of Absolute Change An Exhaustive Analysis of the C1 Nexus Framework, Interface Physics, and the Imperfection Engine Driven by Dean Kulik July 2026 Introduction: The Metaphysics of the Machine and the Keys to the Universe The historic…
  datacite kulik, dean 2026 置信度 0.66
• The Self-Reading Substrate: Exhaustive Resolution of the C1 Operational Geometry and Standard Model Derivations
  The Self-Reading Substrate: Exhaustive Resolution of the C1 Operational Geometry and Standard Model Derivations Driven by Dean Kulik July 2026 The Engine of Immutable Change and the Dissolution of the Observer The fundamental architecture of physical reality, …
  datacite kulik, dean 2026 置信度 0.66
• GTIM A Route-Scoped Evidence Operations and Discovery Governance Framework
  GTIM A Route-Scoped Evidence Operations andDiscovery Governance Framework Technical Report and Worked Case Study Case study: KRAS G12D-mutant pancreatic ductal adenocarcinomaMRTX1133-induced autophagy-glutathione escape Bouchelit Mohammed El AminGTIM - Indepen…
  datacite Bouchelit, Mohammed El Amin 2026 置信度 0.66
• The Theory of Readability Constraint Geometry, Observer-Relative Resolution, and the Operational Substrate of the Anti-Theory
  The Theory of Readability Constraint Geometry, Observer-Relative Resolution, and the Operational Substrate of the Anti-Theory Introduction: The Epistemological Crisis and the Ontological Inversion For over a century, the trajectory of contemporary theoretical …
  datacite kulik, dean 2026 置信度 0.66
• In Silico Design and Computational Validation of a Tri-Modular Genetic Circuit for Autonomous Detection and Bioremediation of Hexavalent Chromium in Closed-System Microcosms
  Hexavalent chromium [Cr(VI)], a Group 1 IARC carcinogen, reaches up to 3.54 mg/L in Bangladesh’s BurigangaRiver (35-fold above the US EPA limit) due to unregulated tannery effluent. Existing remediation is passive, lackingreal-time sensing, dose-responsive tre…
  datacite Shaad, Zubayer Hasan 2026 置信度 0.66 Genetic CircuitHexavalent Chromium (Cr(VI))Computational BiologySynthetic BiologyEscherichia coli
• The Consciousness Triangle. Zygotic Zinc Spark (Origin), Chromosome 1 (Flow), and the Brainstem Locus Coeruleus Nucleus (Destiny). Consciousness is a Continuous Electromagnetic-Telecommunication Event, Not Discrete Chemical. (9).
  این تحلیل فنی، طبق پروتکلِ ۱۰ مرحله‌ایِ شما و در چارچوبِ «مکانیک تانسوری ۱۱۵۵-D حمزه»، به بررسیِ ساختاریِ کروموزوم ۱ به عنوانِ «سکتورِ بوت» (Boot Sector) و «کرنلِ سیستمِ آگاهی» می‌پردازد. ما در این‌جا از دیدگاهِ بیولوژیِ کلاسیک (که آن را «دنیایِ جانک» یا زباله…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• Low Power Design Techniques for Digital Logic Circuits.
  With the rapid increase in the density and size of chips and systems, area and power dissipation have become critical concerns in Very Large Scale Integrated (VLSI) circuit design. Low-power design techniques are essential for today's VLSI industry. The histor…
  datacite Xia, Yinshui 2003 置信度 0.66
• THE UNIVERSAL INSTRUMENT Reorientation and the Geodesic Return
  THE UNIVERSAL INSTRUMENT Reorientation and the Geodesic Return Driven by Dean Kulik June 2026 Introduction: The Crisis of Distinction and the Terminal Axiom For over a century, the trajectory of theoretical physics, computational mathematics, and systemic onto…
  datacite kulik, dean 2026 置信度 0.66
• (1).The Solution of 170 Unanswered Puzzles Across All Branches of Pure and Applied Mathematics via the 1155-Dimensional Tensor Mechanics of the Hamzah Equation.
  برای ورود به «تراز صفرِ مطلقِ ریاضیات» و اثبات قطعی ۱۷ شاخه دانش از طریق تانسور ۱۱۵۵-بعدی حمزه، نیاز به یک ابر-ساختار است که ریاضیات محض را به فیزیک تانسوری و سپس به کد اجرایی گره بزند. این لاگرانژی جدید، نه برای توصیف، بلکه برای «اجبار مانیفولد به پایداری» طر…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• Algorithms in computer-aided design of VLSI circuits.
  With the increased complexity of Very Large Scale Integrated (VLSI) circuits, Computer Aided Design (CAD) plays an even more important role. Top-down design methodology and layout of VLSI are reviewed. Moreover, previously published algorithms in CAD of VLSI d…
  datacite Yang, Meng 2006 置信度 0.66
• A Deterministic Two-Layer Interpretation of DNA: One Operator Reading Five Grammar Levels, with a Structurally-Complete (100%) Decoding Declaration
  A single deterministic engine reads DNA's readable layer completely and mechanically from sequence alone. Given any locus it returns the material γ (stacking stiffness, = −mean nearest-neighbour stacking ΔG, SantaLucia 1998), the A4 coordinate (shell, nearest …
  datacite Lee, Young Jae 2026 置信度 0.66 DNA interpretationquantity as runtimechromatin compartmentsHi-CA/B compartments
• Design and Construction of an UFO. Interstellar and Intergalactic Travel Utilizing Zero-Point Energy and Non-Newtonian Propulsion Systems (0).
  پروتکل مهندسی و شبیه‌سازی تانسوری «سفینه حمزه» (تراز ۱۱۵۵ بعدی)، این ساختار از پارادایم «مکانیک صلب» به «دینامیک رندرینگ اطلاعاتی» گذار کرده است. ۱. چارچوب ریاضی: لاگرانژین مطلق و دترمینان ژاکوبی در این دکترین، سفینه یک جسم صلب نیست، بلکه یک «آبجکت منطقی» (Log…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• Immortality Index: A Binary Milestone Registry for Longevity Research
  Biological aging constitutes a progressive, multi-system accumulation of en-tropic failure across two interacting substrates:epigenetic configuration —herein termed cellular software — and somatic mutational burden, compris-ing the hardware layer.Current trans…
  datacite Immortality Index 2026 置信度 0.66 Engineered Negligible SenescenceSomatic Identity VerificationFault-Tolerant Biological NetworksParacrine-Mediated RemodellingBio-orthogonal Surveillance
• Jacobian Determinant Matrix of the 1155-Dimensional Tensorial Mechanics of the Hamzah Equation
  بدون هیچ‌گونه تغییر، حذف، تلخیص یا ساده‌سازی در ساختار مفاهیم، کل پیکربندی ریاضیاتی، تانسوری و مانیفست پدیدارشناسی مربوط به «اَبَرماتریس ژاکوبی کلان» ($\mathbb{J}_{\text{Master}}$) در تراز لاگرانژی $L_{1155}$ به عنوان مرجع استخراج تمام ۱۰۰ مورد ساختاری، فرکانس…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• The Origin of Life Is not Darwinian nor Chemical Evolution of Neurons But Indeed Is the Coherence of Information within an Electromagnetic Field. Life Is the Invocation and Installation of Software from Source Code via the 98% "Junk DNA" as a Fractal Antenna and DNA Is a Hilbertian Fractal Spiral Curve, and Telomeres Are Conical Filters of Wavelength and Frequency upon the Hardware of the Body. Death Is the Disconnection of Failed Hardware from Un-Updated Software Which is Failure of the Hardware But the Persistence of the Software of Life within a Cosmic Processing Archive, within the Framework of the 1155-Dimensional Tensor Mechanics of the Hamzah Equation.
  ۱. ابَر-لاگرانژی حیات ۱۱۵۵ (The Bio-Cybernetic Lagrangian) این معادله، حکمرانِ مطلق بر فرآیند فراخوانی، نصب و پایداری اطلاعات در میدان الکترومغناطیسی بدن است: $$\mathcal{L}_{Life}^{(1155)} = \oint_{\mathbb{H}} \left[ \underbrace{\sum_{k=1}^{1155} \Psi_{k} \cdo…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• Answers to the Mysteries of Time.(1).
  در چارچوب مانیفست هوش کوانتومی حمزه (HQI) و با تکیه بر زیرساخت ۱۱۵۵ بعدی، «پیکان زمان» دیگر نه یک قانون آماری از فروپاشی، بلکه یک «بردار گشتاور جهانی» است. در ادامه، کالبدشکافی فنی و دقیق «مورد ۱» با پروتکل ۱۲ مرحله‌ای ارائه می‌شود: کالبدشکافی ساختاری مورد ۱: …
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• The Solution to P = NP
  برای تحقق کامل پلتفرم محاسباتی و بستن نهایی مرز ریاضی مسئله $P = NP$، فرمولاسیون ابَرلاگرانژین جامع و قطعی حمزه ($\mathcal{L}_{\text{Unified}}^{1155}$) را در بسط‌یافته‌ترین حالت ساختاری، همراه با تمام پارامترها، اندیس‌های تانسوری و گره‌های کالیبراسیون کالبدشکا…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• Tensorial Tunnelling: Unlike Quantum Tunnelling, a Physical Barrier is not an Obstacle but rather a Folding Point within Higher Dimensions, and the Passage of a Particle (or Data) is not a Random Phenomenon but a Deterministic Geometrical Journey.
  لاگرانژی جامع تونل‌زنی تنسوری (The Grand Unified TT-1155 Lagrangian) این معادله، عبور ذره (یا دیتا) را از یک پدیده «تصادفی» به یک «سفر هندسی قطعی» تبدیل می‌کند. در این ماتریکس، سد فیزیکی نه یک مانع، بلکه یک نقطه تاشدگی در ابعاد بالاتر است: $$\mathcal{L}_{TT}^{…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• A Dissection of the Solar System from the Sun to the Oort Cloud using 1155-Dimensional Tensor Mechanics, Hamzah Equation.
  The Sun: REDO RP BRITISH (Strategic Post-Doctoral Level 1155) ======================================================================================== HQI PROTOCOL NO. 023: THE SOLAR MASTER CLOCK ================================================================…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• Maxwell's Electromagnetic Principles Redefinition and the Union of the Four Fundamental Forces (Gravity, Electromagnetism, the Strong Nuclear Force, and the Weak Nuclear Force)
  STRONG GRAVITATIONAL–ELECTROMAGNETISM INFORMATION, WEAK NUCLEAR $$\mathcal{L}_{Source}^{(1155)} = \oint_{\mathcal{V}_{1155}} \left[ \underbrace{\mathcal{Q}_{\Omega} \left( \mathbb{M}_{multiverse}^{\alpha\beta} \cdot \frac{\partial \mathcal{A}_{nchor}}{\partial…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• المدخل إلى علم قياس السيادةSovereignty Metrology (Ω SVM): The Quantitative Engineering of the Nation-State
  Sovereignty Metrology (Ω‑SVM): The Quantitative Engineering of the Nation-State Author: Mohamed Ali Youssef Part I: Introduction to Sovereignty Metrology Preamble: When Sovereignty Becomes Quantifiable For centuries, sovereignty remained a complex philosophica…
  datacite محمد علي يوسف, محمد على 2026 置信度 0.66
• The Birth of the Mother White Hole and the Final Merger of Black Holes Along a Spiral Vortex Cone Pathway. The Big Bang is, in fact, an Informational Big Boot, resulting from the endless cycles of black-hole mergers and the birth of the Mother White Hole.
  This equation establishes the absolute sovereignty of ordered will across the entire conical fabric of the cosmos: $$\mathcal{L}_{Vortex}^{(1155)} = \oint_{\mathcal{V}_{cone}} \left[ \mathcal{G}_{\Omega} \left( \Phi_{Spiral}^{\mu\nu} \cdot \frac{\partial \math…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• The Nexus Singularity: One Machine Wearing Different Output Skins
  The Nexus Singularity: One Machine Wearing Different Output Skins Driven By Dean A. Kulik June 2026 Introduction: The Ontological Inversion and the Base Class The foundational error of traditional spatial, computational, and linguistic architectures lies in a …
  datacite kulik, dean 2026 置信度 0.66
• Effects of CTCF on the regulatory landscape of the mouse <i>Sox2</i> locus
  Regulatory elements that control gene transcription are scattered along the genome, yet it is still poorly understood how their precise positioning affects the regulatory landscape. We previously reported a method to relocate a regulatory element to thousands …
  preprints 2026 置信度 0.74
• Billion-Scale Deciphering of Human Gene Regulatory Grammar
  Predicting how DNA sequence specifies gene expression remains a core challenge across regulatory genomics. Most predictive assays and models depend on native genomic DNA, constraining the full biochemical engineering space for assessing and designing new seque…
  preprints 2025 置信度 0.74
• Impact of exogenous aminoacyl-tRNA synthetase and tRNA on temperature sensitivity in <i>Escherichia coli</i>
  Genetic code expansion (GCE) is a powerful strategy that expands the genetic code of an organism for incorporating non-canonical amino acids (ncAAs) into proteins using engineered tRNAs and aminoacyl-tRNA synthetases (aaRSs). While GCE has opened up new possib…
  preprints 2024 置信度 0.74
• Quantitative profiling of millions of nucleotides reveals sequence-encoded interactions that govern plasmid propagation
  Plasmids are central to modern biotechnology, especially therapeutic development, yet their propagation in Escherichia coli remains difficult to predict. Although expression-induced burden is well understood and can be mitigated, the impact of foreign DNA segm…
  preprints 2025 置信度 0.74
• Rewiring native post-transcriptional carbon regulators to build multi-layered genetic circuits and optimize engineered microbes for bioproduction
  As the bioprocessing and synthetic biology spaces rapidly expand, post-transcriptional regulation is emerging as driver for maximizing signal response rate and for minimizing cost per protein within cells. Designing robust post-transcriptional control systems …
  preprints 2023 置信度 0.74
• Regulatory logic of human cortex evolution by combinatorial perturbations
  Comparative genomic studies between contemporary and extinct hominins revealed key evolutionary modifications, but their number has hampered a system level investigation of their combined roles in scaffolding modern traits. Through multi-layered integration we…
  preprints 2025 置信度 0.74
• TET2 loss promotes premalignant survival and clonal selection in MYC-driven B cell lymphoma
  The DNA demethylase ten-eleven translocation enzyme 2 (TET2) is frequently inactivated in hematologic malignancies, yet how its loss shapes oncogene-driven transformation remains unclear. Using a mouse model in which MYC is overexpressed in the B cell lineage,…
  preprints 2026 置信度 0.74
• Unigems: plasmids and parts to facilitate teaching on assembly, gene expression control and logic in E. coli
  Synthetic biology enables the creative combination of engineering and molecular biology for exploration of fundamental aspects of biological phenomena. However, there are limited resources available for such applications in the educational context, where strai…
  preprints 2021 置信度 0.74
• Distribution, assembly and mechanism of GluN1/GluN3A excitatory glycine receptors
  ABSTRACT NMDA receptors play key roles in brain development, plasticity and diseases. While glutamate and glycine co-gated GluN2-containing NMDARs have been extensively characterized, little is known regarding GluN3A-containing NMDARs that form receptors gated…
  preprints 2026 置信度 0.74
• Plasma membrane nanoscale dynamics of <i>Arabidopsis</i> leucine-rich repeat receptor kinase complexes
  Plasma membrane-localized receptors operate as dynamic signaling complexes and integrative networks 1–3 , yet the spatial and temporal regulation of these interactions remain largely unknown. Here, by analyzing the components of a minimal Arabidopsis leucine-r…
  preprints 2026 置信度 0.74
• Midbrain <i>Tet1</i> dosage defines inter-individual binge-eating susceptibility
  Binge-eating disorder (BED) is the most common eating disorder worldwide and carries life-altering comorbidities. While genetic and environmental risk factors have been identified, the mechanisms that determine inter-individual susceptibility to BED remain lar…
  preprints 2026 置信度 0.74
• A foundational model for joint sequence-function multi-species modeling at scale for long-range genomic prediction
  Genomic prediction and design require models that integrate local sequence features with long-range regulatory dependencies spanning hundreds of kilobases to megabases. Existing approaches have made substantial progress along complementary axes: supervised seq…
  preprints 2025 置信度 0.74
• An engineered multi-step differentiation program in <i>Escherichia coli</i> for self-organized spatial patterning
  In nature, complex multicellular structures originate from individual cells containing all essential information for differentiation, patterning and morphogenesis. Synthetic biology enables a bottom-up approach to study these processes by engineering and combi…
  preprints 2025 置信度 0.74
• Chimeric MerR-Family Regulators and Logic Elements for the Design of Metal Sensitive Genetic Circuits in <i>Bacillus subtilis</i>
  ABSTRACT Whole-cell biosensors are emerging as promising tools for monitoring environmental pollutants such as heavy metals. These sensors constitute a genetic circuit comprising a sensing module and an output module, such that a detectable signal is produced …
  preprints 2022 置信度 0.74
• Genomic and Epigenetic Interplay Drives Adaptive Fusion via Reproduction Trade-Off
  Summary Investment in sexual reproduction has long been seen as a fitness cost for asexual proliferation, raising the question of how cells evolve to accommodate cyclical demands of sexual and asexual cycles. We addressed this question by evolving Schizosaccha…
  preprints 2025 置信度 0.74
• A history-dependent integrase recorder of plant gene expression with single cell resolution
  During development, most cells experience a progressive restriction of fate that ultimately results in a fully differentiated mature state. Understanding more about the gene expression patterns that underlie developmental programs can inform engineering effort…
  preprints 2024 置信度 0.74
• HCR-Proxy resolves site-specific proximal RNA proteomes at subcompartmental nanoscale resolution
  ABSTRACT The spatial organization of RNA condensates is fundamental for understanding of basic cellular functions, but may also provide pivotal insights into diseases. One of the major challenges to understanding the role of condensates is the lack of technolo…
  preprints 2025 置信度 0.74
• A perspective on information optimality in a neural circuit
  The nematode worm Caenorhabditis elegans has a relatively simple neural system for analysis of information transmission from sensory organ to muscle fiber. Therefore, an example of a neural circuit is analyzed that originates in the nematode worm, and a method…
  preprints 2021 置信度 0.74
• A novel Genetically Engineered Microbial (GEM) biosensor for specific detection of Cd 2+ , Zn 2+ and Pb 2+ heavy metals; calibration and validation aspects
  Background: In this study, we designed a novel genetic circuit sensitive to Cd 2+ , Zn 2+ and Pb 2+ by mimicking the CadA/CadR operon system mediated heavy metal homeostasis mechanism of Pseudomonas aeruginosa . The regular DNA motifs on natural operon were re…
  preprints 2023 置信度 0.74
• The Regulatory Logic of Planarian Stem Cell Differentiation
  Cell type identity is determined by gene regulatory networks (GRNs), comprising the expression of specific transcription factors (TFs) regulating target genes (TGs) via binding to open chromatin regions (OCRs). The regulatory logic of differentiation includes …
  preprints 2024 置信度 0.74
• CRISPRi-based circuits for genetic computation in plants
  Synthetic gene circuits can enable new cellular behaviours by integrating multiple input signals into customisable genetic programs. However, gene circuit development in plants has been limited by a lack of orthogonal and modular parts required for their const…
  preprints 2022 置信度 0.74
• A Synthetic Genetic Reversible Feynman Gate in a Single <i>E.coli</i> Cell and its Application in Bacterial to Mammalian Cell Information Transfer
  Reversible computing is a nonconventional form of computing where the inputs and outputs are mapped in a unique one-to-one fashion. Reversible logic gates in single living cells have not been demonstrated. Here, we created a synthetic genetic reversible Feynma…
  preprints 2021 置信度 0.74
• An Aggregation Prone Region (APR) in talin controls talin self-interactions to regulate integrin adhesion complex dynamics
  The tight regulation of the integrin family of extracellular matrix (ECM) receptors is essential for the coordination of most cellular processes. Talin regulates integrin function by binding to the cytoplasmic tail of the integrin beta subunit. Two integrin-bi…
  preprints 2026 置信度 0.74
• Automated Design of Robust Genetic Circuits: Structural Variants and Parameter Uncertainty
  Genetic design automation methods for combinational circuits often rely on standard algorithms from electronic design automation in their circuit synthesis and technology mapping. However, those algorithms are domain-specific and are hence often not directly s…
  preprints 2021 置信度 0.74
• Phage-Assisted Evolution of Allosteric Protein Switches
  Allostery, the transmission of locally induced conformational changes to distant functional sites, is a key mechanism for protein regulation 1 . Artificial allosteric effectors enable remote manipulation of cell function 2,3 ; their engineering, however, is ha…
  preprints 2025 置信度 0.74
• Contextual dependencies expand the re-usability of genetic inverters
  The design and implementation of Boolean logic functions in living cells has become a very active field within synthetic biology. By controlling networks of regulatory proteins, novel genetic circuits are engineered to generate predefined output responses. Alt…
  preprints 2020 置信度 0.74
• Multiplexed Cell-Based Diagnostic Devices for Detection of Renal Biomarkers Using Genetic Circuits
  The number of synthetic biology based solutions employed in the medical industry is growing every year. The whole cell biosensors being one of them, have been proven valuable tools for developing low-cost, portable, personalized medicine alternatives to conven…
  preprints 2021 置信度 0.74
• Streamlined and efficient genome editing in <i>Cupriavidus necator</i> H16 using an optimised SIBR-Cas system
  Cupriavidus necator H16 is a promising microbial platform strain for CO 2 valorisation. While C. necator is amenable to genome editing, existing tools are often inefficient or rely on lengthy protocols, hindering its rapid transition to industrial applications…
  preprints 2024 置信度 0.74
• Next-generation biocomputing: mimicking artificial neural network with genetic circuits
  Artificial neural network (ANN) is nowadays one of the most used and researched computational methods. In the field of biocomputing, however, synthetic biologists are still using logic gate technologies to design genetic circuits. We here propose and computati…
  preprints 2021 置信度 0.74
• Dissecting the Determinants of Domain Insertion Tolerance and Allostery in Proteins
  Domain insertion engineering is a promising approach to recombine the functions of evolutionarily unrelated proteins. Insertion of light-switchable receptor domains into a selected effector protein, for instance, can yield allosteric effectors with light-depen…
  preprints 2023 置信度 0.74
• Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
  Genes are often activated by enhancers located at large genomic distances. The importance of this positioning is poorly understood. By relocating promoter-reporter constructs into >1,000 alternative positions within a single locus, we dissected the positional …
  preprints 2024 置信度 0.74
• Designed allosteric protein logic
  SUMMARY Regulation of the activity of proteins enables control of complex cellular processes. Allosteric regulation has been introduced individually into few natural proteins. Here, we present a generally applicable regulation of diverse proteins called INSRTR…
  preprints 2022 置信度 0.74
• Bacterial peptide deformylase inhibitors induce prophages in competitors
  While antibiotics mediate chemical warfare among microbes, their roles in the wild extend beyond direct growth inhibition( 1 ). Some antibiotics have the potential to mediate interference competition by triggering a bacterial stress response that subsequently …
  preprints 2025 置信度 0.74
• A single dose of the antipsychotic drug clozapine has long-term behavioral and functional effects in mice
  SUMMARY Antipsychotic dosing regimens, commonly daily or via slow-release compounds, are designed to maintain steady-state plasma concentrations. They are guided by their plasma half-life that is typically in the range of several hours. This schedule contrasts…
  preprints 2026 置信度 0.74
• Logical Analysis of Response of Health Officials’ Worldwide, to Cost-Effective Early Remedies for COVID19
  With the advent of COVID19, the attitude of health authorities around the world, led mainly by the West, demanded a level of proof as evidence for cheap, non-patented remedies while promoting expensive, patented, and untested remedies by using emergency use au…
  preprints 2022 置信度 0.74
• Construction of two-input logic gates using Transcriptional Interference
  ABSTRACT Transcriptional Interference (TI) has been shown to regulate gene expression at the DNA level via different molecular mechanisms. The obstacles present on the DNA that a transcribing RNA Polymerase might encounter, e.g. a DNA-bound protein or another …
  preprints 2019 置信度 0.74
• Engineering stringent genetic biocontainment of yeast with a protein stability switch
  Abstract Synthetic biology holds immense promise to tackle key problems we are facing, for instance in resource use, environmental health, and human health care. However, comprehensive safety measures are needed to deploy genetically engineered microorganisms …
  preprints 2022 置信度 0.74
• The intersectional genetics landscape for human
  The human body is made up of hundreds, perhaps thousands of cell types and states, most of which are currently inaccessible genetically. Genetic accessibility carries significant diagnostic and therapeutic potential by allowing the selective delivery of geneti…
  preprints 2019 置信度 0.74
• Reprogrammed tracrRNAs enable repurposing RNAs as crRNAs and detecting RNAs
  In type II CRISPR systems, the guide RNA (gRNA) consists of a CRISPR RNA (crRNA) and a hybridized trans-acting CRISPR RNA (tracrRNA) which interacts directly with Cas9 and is essential to its guided DNA targeting function. Though tracrRNAs are diverse in seque…
  preprints 2021 置信度 0.74
• Seamless, rapid and accurate analyses of outbreak genomic data using Split K-mer Analysis (SKA)
  Sequence variation observed in populations of pathogens can be used for important public health and evolution genomic analyses, especially outbreak analysis and transmission reconstruction. Identifying this variation is typically achieved by aligning sequence …
  preprints 2024 置信度 0.74
• Linear-double-stranded DNA (ldsDNA) based AND logic computation in mammalian cells
  Synthetic biology employs engineering principles to redesign biological system for clinical or industrial purposes. The development and application of novel genetic devices for genetic circuits construction will facilitate the rapid development of synthetic bi…
  preprints 2018 置信度 0.74
• Toward a model of uORF-mediated translational control: An integrated bioinformatic and experimental approach
  Upstream open reading frames (uORFs) are short translated regions that occur in the 5□ untranslated regions (5□ UTRs) of mRNA transcripts where they primarily serve to repress expression translation of the downstream primary open reading frame (pORF). Their wi…
  preprints 2025 置信度 0.74
• <i>De-Novo</i> -Designed Translational Repressors for Multi-Input Cellular Logic
  ABSTRACT Synthetic biology aims to apply engineering principles toward the development of novel biological systems for biotechnology and medicine. Despite efforts to expand the set of high-performing parts for genetic circuits, achieving more complex circuit f…
  preprints 2018 置信度 0.74
• The minimal cell-cycle control system in <i>Marchantia</i> as a framework for understanding plant cell proliferation
  ABSTRACT The regulation of cell division is broadly conserved across eukaryotes, governed by cyclins and cyclin-dependent kinases (CDKs) to coordinate progression through the cell cycle. Plants have evolved a complex set of cell-cycle genes with unique feature…
  preprints 2025 置信度 0.74
• Analysis and Prediction of COVID-19 Pandemic in Bangladesh by using Long short-term memory network (LSTM) and Adaptive neuro fuzzy inference system(ANFIS)
  Abstract Objectives: The dangerously contagious virus named SARS-CoV-2 has hit the world hard that has locked downed billion people in their homes for stopping fur- ther spread. All the researchers and scientists in various fields are working around the clock …
  preprints 2020 置信度 0.74
• Resource-aware construct design in mammalian cells
  Resource competition can be the cause of unintended coupling between co-expressed genetic constructs. Here we report quantification of the resource load imposed by different mammalian genetic components and identify construct designs with increased performance…
  preprints 2022 置信度 0.74
• Protein Geometry, Function and Mutation
  A bstract This survey for mathematicians summarizes several works by the author on protein geometry and protein function with applications to viral glycoproteins in general and the spike glycoprotein of the SARS-CoV-2 virus in particular. Background biology an…
  preprints 2022 置信度 0.74
• Multisite gating in tonic sensory circuits integrates multimodal context to control persistent behavioral states
  ABSTRACT Maintaining or shifting between behavioral states according to context is essential for animals to implement fitness-promoting strategies. How integration of internal state, past experience and sensory inputs orchestrate persistent multidimensional be…
  preprints 2022 置信度 0.74
• Programmed hierarchical patterning of bacterial populations
  Modern genetic tools allow the dissection and emulation of fundamental mechanisms shaping morphogenesis in multicellular organisms. Several synthetic genetic circuits for control of multicellular patterning have been reported to date. However, hierarchical ind…
  preprints 2017 置信度 0.74
• Insights from Incorporating Quantum Computing into Drug Design Workflows
  While many quantum computing (QC) methods promise theoretical advantages over classical counterparts, quantum hardware remains limited. Exploiting near-term QC in computer-aided drug design (CADD) thus requires judicious partitioning between classical and quan…
  preprints 2022 置信度 0.74
• Time series analysis and forecasting of China’s energy production during Covid-19: statistical models vs machine learning models
  Abstract COVID-19 is a huge catastrophe of global proportions, and this catastrophe has had far-reaching effects on energy production worldwide. In this paper, we build traditional statistical models and machine learning models to forecast energy production se…
  preprints 2021 置信度 0.74
• Robust digital logic circuits in eukaryotic cells with CRISPR/dCas9 NOR gates
  Summary Natural genetic circuits enable cells to make sophisticated digital decisions. Building equally complex synthetic circuits in eukaryotes remains difficult, however, because commonly used genetic components leak transcriptionally, do not allow arbitrary…
  preprints 2016 置信度 0.74
• SARS-Cov2 seasonality and adaptation are driven by solar activity.
  Abstract Since its isolation, SARS-Cov2 showed a high mutation rate hindering the ability to properly characterize it. Also as a consequence of its size, traditional sequence analysis methods are computationally constrained. Nonetheless, machine learning techn…
  preprints 2023 置信度 0.74
• Selective advantage of mutant stem cells in clonal hematopoiesis occurs by attenuating the deleterious effects of inflammation and aging
  Clonal hematopoiesis (CH) arises when hematopoietic stem cells (HSC) acquire mutations in genes, including DNMT3A and TET2 , conferring a competitive advantage through a mechanism that remains unclear. To gain insight into how CH mutations enable gradual clona…
  preprints 2023 置信度 0.74
• Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition
  Antibodies targeting the SARS-CoV-2 spike receptor-binding domain (RBD) are being developed as therapeutics and make a major contribution to the neutralizing antibody response elicited by infection. Here, we describe a deep mutational scanning method to map ho…
  preprints 2020 置信度 0.74
• Intensive Single Cell Analysis Reveals Immune Cell Diversity among Healthy Individuals
  ABSTRACT It is believed that immune responses are different between individuals and at different times. In addition, personal health histories and unique environmental conditions should collectively determine the present state of immune cells. However, the cel…
  preprints 2021 置信度 0.74
• Transforming descending input into motor output: An analysis of the <i>Drosophila</i> Male Adult Nerve Cord connectome
  In most animals, a relatively small number of descending neurons (DNs) connect higher brain centers in the animal’s head to circuits and motor neurons (MNs) in the nerve cord of the animal’s body that effect movement of the limbs. To understand how brain signa…
  preprints 2023 置信度 0.74
• Network-based elucidation of colon cancer drug resistance by phosphoproteomic time-series analysis
  Aberrant signaling pathway activity is a hallmark of tumorigenesis and progression, which has guided targeted inhibitor design for over 30 years. Yet, adaptive resistance mechanisms, induced by rapid, context-specific signaling network rewiring, continue to ch…
  preprints 2023 置信度 0.74
• Calretinin-expressing islet cells: a source of pre- and post-synaptic inhibition of non-peptidergic nociceptor input to the mouse spinal cord
  ABSTRACT Unmyelinated non-peptidergic nociceptors (NP afferents) arborise in lamina II of the spinal cord and receive GABAergic axoaxonic synapses, which mediate presynaptic inhibition. However, until now the source of this axoaxonic synaptic input was not kno…
  preprints 2023 置信度 0.74
• Reconstitution of monoterpene indole alkaloid biosynthesis in genome engineered <i>Nicotiana benthamiana</i>
  Monoterpene indole alkaloids (MIAs) are a diverse class of plant natural products that include a number of medicinally significant compounds. We set out to reconstitute the pathway for strictosidine, a key intermediate of all MIAs, from central metabolism in N…
  preprints 2021 置信度 0.74
• Rapid identification of optimal drug combinations for personalized cancer therapy using microfluidics
  Functional screening of live patient cancer cells holds great potential for personalized medicine and allows to overcome the limited translatability of results from existing in-vitro and ex-vivo screening models. Here we present a plug-based microfluidics appr…
  preprints 2016 置信度 0.74
• How to Make the Perfect Citizen? Lessons from China's Model of Social Credit System
  The COVID19 crisis has triggered a new wave of digitalization of the lives of citizens. To counter the devastating effects of the virus, states and corporations are experimenting with systems that trace citizens as an integral part of public life. In China, a …
  preprints 2020 置信度 0.74
• Automated 3D multi-color single-molecule localization microscopy
  Since its inception, single molecule localization microscopy (SMLM) has enabled imaging scientists to visualize biological structures with unprecedented resolution. Particularly powerful implementations capable of 3D, multi-color and high-throughput imaging ha…
  preprints 2023 置信度 0.74
• Heterodox Economic Cycles Theory during the COVID-19 Economic Crisis: Social Volatility, Affect and the Finance Market-Real Economy Gap
  The currently ongoing novel Coronavirus-crisis is an external shock coming down on society with direct impact on societal moods and subsequently connected economic changes. With growing digitalization and quickening of transfer speed, information exchange in t…
  preprints 2021 置信度 0.74
• AI-Quantum Phases on Chern-Simons Topological Geometrics for the Generation of A Ligand Targeting COVID-19-SARS-COV-2 SPIKE D614G Binding Sites.
  SARS coronavirus 2 (SARS-CoV-2) in the viral spike (S) encoding a SARS-COV-2 SPIKE D614G mutation protein predominate over time in locales revealing the dynamic aspects of its key viral processes where it is found, implying that this change enhances viral tran…
  preprints 2021 置信度 0.74