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• Noise Tolerant Stochastic Logic Gate Circuits Synthesis using Genetic Algorithms
  In this paper we propose a method for synthesis of combinational networks using non conventional logic gates.The logic components considered are Stochastic Logic Gates (SLGs) able to change their logic functionality by means of a single control parameter and t…
  crossref I. Neri, F. Hartmann 2015-09-18T11:27:50Z 置信度 0.70
• Table 1: Gate logic table.
  crossref 2017-04-18T03:53:19Z 置信度 0.70
• Transmission Gate Logic Circuits
  crossref 2006-01-14T03:03:49Z 置信度 0.70
• Networking 3 K Logic Gate Quantum Processors to Approach 1 Billion Logic Gate Performance
  Outlined is a proposal designed to culminate in the foundry fabrication of arrays of singly addressable quantum dot sources deterministically emitting single pairs of energy-time entangled photons at C-band wavelengths; each pair having negligible spin-orbit f…
  crossref Daniel Guidotti, Gee-Kung Chang, Xiaoli Ma 2024-09-11T01:02:59Z 置信度 0.70
• Using multi-objective genetic programming to evolve stochastic logic gate circuits
  A new stochastic logic gate language is presented. Blossey et al.'s stochastic gene gate language is extended with a complete set of stochastic Boolean gates. Although the gates have behavioural similarities to conventional logic gates, a major difference is t…
  crossref Brian J. Ross 2015-10-20T11:49:46Z 置信度 0.70
• An Initial Investigation on the Generation of Logic Gate Networks using Cartesian Genetic Programming
  crossref Francesco Lubrano, Emanuel Messetti, Alberto Scionti, Giovanni Squillero 等 2026-08-13T20:45:38Z 置信度 0.70
• Design, Fabrication, and Device Chemistry of a 3Input-3-Output Synthetic Genetic Combinatorial Logic Circuit with a 3Input AND Gate in a Single Bacterial Cell
  Advancement of in-cell\nmolecular computation requires multi-input-multi-output\ngenetic logic devices. However, increased physical size, a higher\nnumber of molecular interactions, cross-talk, and complex systems\nlevel device chemistry limited the realizatio…
  crossref 2020-04-07T18:55:38Z 置信度 0.70
• Gate Arrays
  Among all ASIC chips, gate arrays are most widely used because with gate arrays, we can easily realize logic functions that require far more logic gates than with PLAs. If PLAs are used, such logic functions would require far larger area and delay time. Also, …
  crossref 2020-11-12T21:35:24Z 置信度 0.70
• Review for "Solution-processable and Photo-programmable Logic Gate Realized by Organic Non-volatile Floating-gate Photomemory"
  crossref 2025-03-21T17:23:33Z 置信度 0.70
• JMISFET Hybrid Dual-Gate Switching Device for Multifunctional Optoelectronic Logic Gate Applications
  High-performance and low operating voltage are becoming increasingly significant device parameters to meet the needs of future integrated circuit (IC) processors and ensure their energy-efficient use in upcoming mobile devices. In this study, we suggest a hybr…
  crossref 2024-04-17T07:59:25Z 置信度 0.70
• A biochemical logic gate using an enzyme and its inhibitor. Part II: The logic gate
  Enzyme-Based Logic Gates (ENLOGs) are key components in bio-molecular systems for information processing. This report and the previous one in this series address the characterization of two bio-molecular switching elements, namely the alpha-chymotrypsin (alpha…
  crossref Sarit Sivan, Samuel Tuchman, Noah Lotan 2003-05-12T22:41:46Z 置信度 0.70
• Ferroelectric In2Se3 Semi-floating Gate Transistors for Multilevel Memory and Optoelectronic Logic Gate
  Progress in artificial intelligence (AI) demands efficient data storage and high-speed processing. Traditional von Neumann architecture, with space separation of memory and computing units, struggles with increased data transmission, causing power inefficiency…
  crossref 2025-04-23T15:00:11Z 置信度 0.70
• A dynamic logic gate without switching power
  <p>A dynamic logic gate without switching power using an inductor!</p> <p>A new dynamic logic gate that consumes almost no switching power is presented. The stored energy on the load capacitance is transferred to an inductor during logic eval…
  crossref Chakravarthy Mathiazhagan 2023-03-13T23:51:21Z 置信度 0.70
• Field-Programmable Gate Arrays
  FPGAs have other types of hardware, in addition to those with RAMs. Thus, hardware of FPGAs consists of PLDs, logic gates, random-access memory, and often other types of components such as nonvolatile memory. FPGAs from different manufacturers have different o…
  crossref 2020-11-12T16:35:24Z 置信度 0.70
• Networking 3 K Two-Qubit Logic Gate Quantum Processors to Approach 1 Billion Logic Gate Performance
  Outlined is a proposal designed to culminate in the foundry fabrication of arrays of singly addressable quantum dot sources deterministically emitting single pairs of energy-time entangled photons at C-band wavelengths, each pair having negligible spin-orbit f…
  crossref Daniel Guidotti, Xiaoli Ma, Gee-Kung Chang 2024-11-22T04:21:36Z 置信度 0.70
• Floating-Gate Devices in Logic CMOS Processes
  crossref Yanjun Ma, Edwin Kan 2017-03-29T08:09:11Z 置信度 0.70
• Optical and electronic logic gate with orthogonal inputs
  Optoelectronic self-destructive memory device based on multi-segmented nanorods.The paper is currently under preparation.
  crossref Cai Xu 2019-09-10T07:53:40Z 置信度 0.70
• A novel resonant tunneling logic gate capable of 100 fs/gate class operation
  Resonant Tunneling diodes (RTDs) are the most promising candidate for future ultrahigh speed devices. We proposed the MOBILE (MOnostable-BIstable transition Logic Element) for high-speed digital applications exploiting the negative differential resistance (NDR…
  crossref 2020-07-09T23:59:49Z 置信度 0.70
• Reprogrammable Logic Gate and Logic Circuit Based on Multistimuli-Responsive Raspberry-like Micromotors
  In\nthis paper, we report a polymer-based raspberry-like micromotor.\nInterestingly, the resulting micromotor exhibits multistimuli-responsive\nmotion behavior. Its on–off–on motion can be regulated\nby the application of stimuli such as H2O2,\nnear-infrared l…
  crossref 2020-04-08T06:49:42Z 置信度 0.70
• Designing Unconventional Molecular Ternary INHIBIT Logic Gate and Crafting Multifunctional Molecular Logic Systems
  The\npaper describes an improved method for building flexible\ninterswitchable\nlogic gates such as rare-type molecular ternary INHIBIT and combinational\nlogic circuits using a specially designed pyridine-end oligo-p-phenylene­vinylene compound featuring alky…
  crossref 2024-07-09T13:20:35Z 置信度 0.70
• Operating Principles of Gate Gap on Charge Transport in Split Gate Logic Thin-Film Transistors
  Thin-film transistors with a split gate structure have been continuously studied for integration into future electronic devices. By introduction of a gate gap, a thin-film transistor can perform various logic circuit operations within the single channel region…
  crossref 2024-11-21T00:30:16Z 置信度 0.70
• OR gate: ABY=111
  crossref 2026-03-19T06:59:21Z 置信度 0.70
• Figure 6. Natural examples of tandem riboswitches that approximate Boolean logic functions.
  crossref 2018-04-04T06:00:15Z 置信度 0.70
• Towards improvement of SUNA in multiplexers with preliminary results of simple logic gate neuron variation
  Spectrum-Diverse Neuroevolution with Unified Neural Models (SUNA) has been shown to be a successful alternative to the algorithm NeuroEvolution of Augmenting Topologies (NEAT). Requiring less parameters than NEAT yet possessing a more unified representation po…
  crossref Anh Due Ta, Danilo Vasconcellos Vargas 2020-08-26T15:26:55Z 置信度 0.70
• D-Gate Logic
  crossref 2012-07-18T23:11:44Z 置信度 0.70
• Video for A New Logic-Locking Scheme Resilient to Gate Removal Attack
  crossref 2020-09-29T09:22:27Z 置信度 0.70
• Decision letter for "Solution-processable and Photo-programmable Logic Gate Realized by Organic Non-volatile Floating-gate Photomemory"
  crossref 2025-03-21T17:23:33Z 置信度 0.70
• AND gate: ABY=100
  crossref 2026-03-19T06:59:21Z 置信度 0.70
• Reduction of Leakage Power for VLSI Design Logic Gate Circuits
  High power dissipation has become key role in VLSI design circuits, when it comes to battery -operated applications it is important to save the battery life.Short -circuit power and switching power play key role in power dissipations, there are so many techniq…
  crossref Kiran Renukuntla 2024-05-18T07:49:54Z 置信度 0.70
• Identifying Transparent Logic in Gate-Level Circuits
  crossref Yu-Yun Dai, Robert K. Brayton 2017-11-15T07:36:44Z 置信度 0.70
• Combinational logic gate elements
  crossref S.A. Knight 2013-11-19T04:56:01Z 置信度 0.70
• Thrombin Nanochannel Logic Gate Inspired by BioMemory
  The process of “reading” and “writing” in biomemory involves the transmission of electrical signals between neurons, with ligand-gated ion channels assuming a key role. The solid-state nanochannels exhibit certain similarities with neurons. Information transmi…
  crossref 2024-12-02T10:10:36Z 置信度 0.70
• molecular logic gate
  Citation: 'molecular logic gate' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.09531 • License: The IUPAC Gold Book is licensed under Creative Com…
  crossref 2024-11-08T18:33:04Z 置信度 0.70
• Folded gate—A novel logic gate structure
  We propose a new logic gate structure which consists of two semiconducting layers separated by an insulator. The input electrode is a rectifying contact to the top conducting layer which acts as a channel of a switching field-effect transistor. The bottom cond…
  crossref M. Shur 2008-01-12T00:52:49Z 置信度 0.70
• Fuzzy Logic and Attention Gate for Improved U-Net with Genetic Algorithm for DFU Image Segmentation
  Diabetic Foot Ulcers (DFU) require effective management through early diagnosis and appropriate treatment. Image segmentation is very important in the management of DFU to identify the ulcer area. The popularity of U -Net architecture in the field of medical i…
  crossref Purwono Purwono, Yessica Nataliani, Hindriyanto Dwi Purnomo, Ivanna K. Timotius 2024-10-02T18:16:47Z 置信度 0.70
• Review for "Five-membered heterocycles as promising platforms for molecular logic gate construction"
  crossref 2025-04-05T17:15:51Z 置信度 0.70
• Logic Optimization
  crossref Rajeev Murgai, Robert K. Brayton, Alberto Sangiovanni-Vincentelli 2012-07-28T19:16:43Z 置信度 0.70
• Spin torque majority gate logic
  Introduction Nanomagnetic or spintronic circuits hold the promise of non-volatile and reconfigurable logic with low switching energy. One such circuit is the magnetic majority gate formed by concatenating several magnetic tunnel junctions together in such a ma…
  crossref Dmitri E. Nikonov, George I. Bourianoff 2015-02-09T09:59:44Z 置信度 0.70
• Independent Gate Skewed Logic in Double-Gate SOI Technology
  Independent gate control of double gate SOI devices (D. Fried, 2003 and L. Mathew, 2004) can be effectively exploited to improve performance and reduce power in sub-50nm circuits. In this paper, we have proposed a skewed logic style using independent gate oper…
  crossref T. Cakici, H. Mahmoodi, S. Mukhopadhyay, K. Roy 2006-01-05T14:52:38Z 置信度 0.70
• Mapping Combinational Logic
  crossref Rajeev Murgai, Robert K. Brayton, Alberto Sangiovanni-Vincentelli 2012-07-28T19:16:43Z 置信度 0.70
• Chelated Magnesium Logic Gate Regulates Riboswitch Pseudoknot Formation
  Magnesium\nplays a critical role in the structure, dynamics, and\nfunction of RNA. The precise microscopic effect of chelated magnesium\non RNA structure is yet to be explored. Magnesium is known to act\nthrough its diffuse cloud around RNA, through the outer …
  crossref 2021-06-09T14:26:00Z 置信度 0.70
• DNA Sequential Logic Gate Using Two-Ring DNA
  Sequential DNA detection is a fundamental\nissue for elucidating\nthe interactive relationships among complex gene systems. Here, a\nsequential logic DNA gate was achieved by utilizing the two-ring DNA\nstructure, with the ability to recognize “before” and\n“a…
  crossref 2020-04-08T07:45:03Z 置信度 0.70
• Application Analysis of Logical Effort Theory in VLSI Logic Gate Sizing Optimization
  crossref Zirui Zheng 2026-02-25T21:34:04Z 置信度 0.70
• Logic gate symbols
  crossref Keith Brindley 2013-11-18T01:01:27Z 置信度 0.70
• New universal gate library for synthesizing reversible logic circuit using genetic programming
  We newly formed universal gate library, that includes NOT, CNOT (Feyman), Toffoli, Fredkin, Swap, Peres gates and a special gate called G gate. The gate G on its own is a universal gate, but using it alone in a library will result in large circuit realization.…
  crossref Mustapha Yusuf Abubakar, Low Tang Jung, Mohamed Nordin Zakaria, Ahmed Younesy 等 2016-12-19T17:11:34Z 置信度 0.70
• Allosteric Logic Gate
  Abstract Allostery enables proteins to transmit local perturbations to distant functional residues, providing a biophysical basis for molecular signal integration. Here we introduce an Allosteric Logic Gate (ALG): an elastic network designed to convert two ind…
  crossref Davide Cois, Sahand Jamal Rahi, Paolo De Los Rios 2026-05-02T03:55:19Z 置信度 0.70
• Mapping Sequential Logic
  crossref Rajeev Murgai, Robert K. Brayton, Alberto Sangiovanni-Vincentelli 2012-07-28T19:16:43Z 置信度 0.70
• DNAzyme-Based Logic Gate-Mediated DNA Self-Assembly
  Controlling DNA self-assembly processes using rationally\ndesigned logic gates is a major goal of DNA-based nanotechnology and\nprogramming. Such controls could facilitate the hierarchical engineering\nof complex nanopatterns responding to various molecular tr…
  crossref 2020-04-09T12:30:36Z 置信度 0.70
• Moebius circuit
  We have introduced the concept of the Moebius strip into LSI circuit design, realizing 8.4 FO4-Inverter throughput for any kind of digital logic circuit. The Moebius circuit operates in a logic gate level pipeline, and has error detection and error gate search…
  crossref MyeongGyu Jeong, Toru Nakura, Makoto Ikeda, Kunihiro Asada 2009-05-12T12:52:47Z 置信度 0.70
• Logico-Genetic Theorizing
  The general features of logico-genetic theorizing are explained. The Natural Logicism advanced in this study is an example. This kind of theorizing is concerned to clarify rational beings’ entitlement to various familiar species of mathematical object. A logic…
  crossref Neil Tennant 2022-03-24T02:47:06Z 置信度 0.70
• A Triethylenetetramine Bearing Anthracene and Benzophenone as a Fluorescent Molecular Logic Gate with Either-Or Switchable Dual Logic Functions
  Fluorescence behaviors of a triethylenetetramine bearing anthracene (AN) and benzophenone (BP) fragments\nat the respective ends, L1, have been studied in water, where effects of pH (H+) and metal cations on the\nemission properties have been studied in detail…
  crossref 2020-04-08T12:32:52Z 置信度 0.70
• Fewer Lasers Achieve Higher Fidelity Logic Gate
  Fewer Lasers Achieve Higher Fidelity Logic GateResearchers halve the number of lasers needed to implement a quantum logic gate between two different atomic species, a feat that could help to create a scalable quantum computer.
  crossref Katherine Wright 2020-08-18T15:53:28Z 置信度 0.70
• Microfit: Microcomputer Based Gate Level Logic Simulator
  crossref Y.A. Alsaka 2005-08-24T20:50:14Z 置信度 0.70
• Ambipolar independent double gate FET (Am -IDGFET) logic design : methods and techniques
  Méthodes et techniques de synthèse des circuits logiques à base des transistors ambipolaires à double grille La croissance continue de la demande mondiale des produits semi-conducteurs (dans un large éventail de secteurs, tels que la sécurité, la santé, le div…
  crossref Kotb Jabeur 2026-03-30T22:48:08Z 置信度 0.70
• Logic Gate
  crossref 2008-05-23T15:40:29Z 置信度 0.70
• Gate-Controlled Electron Quantum Interference Logic
  Abstract Inspired by using the wave nature of electrons for electronquantum optics, we propose a new type of electron quantuminterference structure, where single-electron waves are coherentlyinjected into a gate-controlled, two-dimensional waveguide andexit th…
  crossref Josef Weinbub, Mauro Ballicchia, Mihail Nedjalkov 2022-01-17T16:40:26Z 置信度 0.70
• Incremental Logic Synthesis through Gate Logic Structure Identification
  This paper describes incremental logic synthesis for supporting function logic changes in the physical design stage of digital systems. The incremental logic synthesis is distinguished from logic synthesis in the respect that it updates only gate logic compone…
  crossref T. Shinsha, T. Kubo, Y. Sakataya, J. Koshishita 等 2012-04-16T12:44:44Z 置信度 0.70
• Redox Active Binary Logic Gate Circuit for Homeland Security
  Bipolar\njunction transistors are at the frontiers of modern electronics\nowing to their discrete voltage regulated operational levels. Here\nwe report a redox active binary logic gate (RLG) which can store a\n“0” and “1” with distinct operational\nlevels, alb…
  crossref 2020-04-06T16:49:00Z 置信度 0.70
• Three-Input Logic Gate Based on DNA Strand Displacement Reaction
  Abstract In this paper, three kinds of three-input logic gates are designed based on DNA strand displacement reaction, which are three-input OR logic gate, three-input AND logic gate, and three-input MAJORITY logic gate. The logic gates designed in this paper …
  crossref Jingjing Ma 2023-06-05T18:54:50Z 置信度 0.70
• New logic gate uses quantum states
  crossref 2017-01-31T11:52:05Z 置信度 0.70
• Inverter, gate, and logic circuits
  crossref R.M. Marston 2013-11-19T19:10:31Z 置信度 0.70
• A 3-input Universal Logic Gate (ULG) using a Single Electron Linear Threshold Gate (LTG)
  The Single Electron NanoDevices (SENDs) are attractive candidates for post-CMOS VLSI era mainly due to its very low power consumption. In this paper, the Single Electron (SE) Linear Threshold Gate (LTG) is reviewed. A 3-input Universal Logic Gate (ULG) is prop…
  crossref Sameh Ebrahim Rehan 2012-05-24T22:27:29Z 置信度 0.70
• Genetic Circuits Logic Analysis
  crossref Hasan Baig, Jan Madsen 2020-09-25T06:02:54Z 置信度 0.70
• CMOS Ternary Logic Gate Implementation utilizing Domino Logic
  In advanced CMOS VLSI systems, optimizing power consumption, delay, and signal integrity is critical—especially in the design of multi-valued logic systems. This paper proposes an enhanced domino logic architecture, called Foot-Driven Stack Transistor Domino L…
  crossref Babu Adra, H Shree Kumar 2026-04-07T19:54:53Z 置信度 0.70
• Gate Voltage- and Bias Voltage-Tunable Staggered-Gap to Broken-Gap Transition Based on WSe2/Ta2NiSe5 Heterostructure for Multimode Optoelectronic Logic Gate
  Two-dimensional (2D) materials with superior properties exhibit tremendous potential in developing next-generation electronic and optoelectronic devices. Integrating various functions into one device is highly expected as that endows 2D materials great promise…
  crossref 2024-04-18T01:20:30Z 置信度 0.70
• Ultrafast Ultraviolet Optoelectronic Logic Gate Devices with Ultralow Energy Consumption
  crossref 2026-05-28T17:01:43Z 置信度 0.70
• A novel D-latch in multiple-valued semi-floating-gate recharged logic
  In this paper, we present several different proposals for implementing a multiple-valued (MV) semi-floating-gate (SFG) D-latch. This paper aims to illustrate the advantages and disadvantages of each approach. Measurements from a fabricated chip in a 0.6 /spl m…
  crossref O. Mirmotahari, Y. Berg 2004-09-28T09:50:22Z 置信度 0.70
• Optical Cellular Logic Computers And Space-Variant Logic Gate Array
  A general approach is described for optically implementing massively parallel logic. Cellular array logic and the cellular automaton theory are emphasized as a guiding principle in the design of optical parallel computers. These theoretical approaches are impo…
  crossref Toyohiko Yatagai 2012-10-02T16:42:17Z 置信度 0.70
• A new CMOS gate-the balanced gate-for detecting physical failures
  An approach to design-for-testability of CMOS logic circuits is presented. The method is based on design with a new family of gates, called balanced gates. These gates have an extra logic level that is used for testing. In the test mode, all the inputs to a ga…
  crossref O.E. Katter, H.M. Razavi 2002-12-04T20:46:26Z 置信度 0.70
• Near-Infrared Responsive Ionoelastomer Junction Enabling Switchable Ionic Logic Gate
  Despite the significant progress in the development of ionic junctions of two types of ionic conductors for ionic current rectification, reminiscent to electronic p- and n-type junctions, stimuli-responsive ionic junctions wherein stimuli reversibly control cu…
  crossref 2025-12-12T13:51:21Z 置信度 0.70
• Single-gate logic solutions for space-constrained designs
  Until recently, most standard logic ICs were still only available as multiple functions in a single package. Now, by using small outline 5-pin packages such as SOT23 or SC70, standard logic ICs can be purchased as single function, small package devices. Severa…
  crossref C.R. Poirier 2002-11-22T20:47:57Z 置信度 0.70
• Signal logic gate mediated by a controllable CRISPR/Cas12a system for simultaneous detection of DNA mutation and methylation.
  Early detection of both genetic mutations and epigenetic modifications is critical for cancer diagnosis, but current methods often require separate assays or suffer from bisulfite-induced DNA damage. Here, we present a controllable CRISPR/Cas12a-based signal l…
  europepmc 2026 置信度 0.80
• Growth control as a central regulator for tuning the cellular context.
  The cellular context decisively shapes genetic circuit performance, but the interplay between host and circuit remains difficult to control rationally. To address this challenge, we replaced the native regulatory machinery of RNA polymerase (RNAP) from the bac…
  europepmc 2025 置信度 0.80
• Intracellular logic computing with DNA tetrahedron processors enables precision cancer theranostics.
  The integration of molecular computation with nanomedicine holds transformative potential for precision cancer theranostics. However, achieving an intelligent, multi-input decision-making process within living cells remains a formidable challenge because of th…
  europepmc 2026 置信度 0.80
• Ritual Spatial Narrative in the Dai Temple Complex Based on Space Syntax Theory
  Abstract Ancient Chinese architectural complexes embody profound cultural genetic codes of ritual.As the central ceremonial venue for the imperial Feng and Shan sacrifices (sacrifices to Heaven and Earth), the Dai Temple developed a distinctive ritual spatial …
  europepmc 2026 置信度 0.80
• Orchestrating triacylglycerol biosynthesis and hydrolysis via synthetic genetic circuits enhances spinosad production in Streptomyces albus.
  Spinosad, a potent insecticidal secondary metabolite, is biosynthesized with acetyl-CoA as the key precursor. Triacylglycerols (TAGs) can supply acetyl-CoA via β-oxidation, but the regulatory link between TAG metabolism and spinosad biosynthesis in Streptomyce…
  europepmc 2026 置信度 0.80
• Loop-recognition dual-hairpin competitive probes enabling a dual-ratiometric electrochemical platform for specific SNP discrimination and logic gate construction.
  Accurate discrimination of single nucleotide polymorphisms (SNPs) remains a fundamental challenge in nucleic acid biosensing due to the minimal thermodynamic differences between perfectly matched and single-base mismatched sequences. This intrinsic limitation …
  europepmc 2026 置信度 0.80
• Smart control of CAR-T cells: emerging strategies for safer and more effective cancer immunotherapy.
  Chimeric Antigen Receptor (CAR)-T cell therapy has developed cancer immunotherapy but remains restricted by severe toxicities, antigen escape, and loss of efficacy in solid tumors. Recent advances in smart control systems aim to enhance the safety and precisio…
  europepmc 2026 置信度 0.80
• PANDA: AND logic-gated RNA sensing enabled by a photo-activated RCA-Argonaute cascade.
  Achieving stable, multiplexed, and affordable nucleic acid detection in a true one-pot format remains a long-standing challenge for molecular diagnostics. Here, we report PANDA, a photo-activated rolling circle amplification (RCA)-Argonaute (Ago) cascade that …
  europepmc 2026 置信度 0.80
• Synthetic promoter design in plants: integration of computational and experimental approaches.
  Understanding how to engineer transcriptional regulation in plants is key to advancing both fundamental knowledge and practical applications in plant biology. Native gene promoters, while widely used, are constrained by evolutionary pressures that limit their …
  europepmc 2026 置信度 0.80
• Hierarchical TBX6-FOXC Regulatory Logic Governs Human Trunk Mesoderm Diversification
  Summary Mesoderm forms during gastrulation and diversifies to generate many embryonic tissues, yet the regulatory logic governing early human mesodermal lineage decisions remains poorly defined. We use human iPSC-derived 3D trunk-like structures (hTLS) to mode…
  europepmc 2026 置信度 0.80
• SpChipADF: An Architecture Design Framework for Radar Signal Processing Hardware Accelerators.
  Lightweight Unmanned Aerial Vehicles (UAVs) have limited space, low payload capacity, and constrained power supply capabilities. Therefore, their payloads are constrained by size, weight, and power (SWaP). Thus, designing edge-side signal processing architectu…
  europepmc 2026 置信度 0.80
• CAR-T cell therapy for pancreatic cancer: Translating emerging targets and dual-targeting strategies from solid tumors.
  Pancreatic ductal adenocarcinoma (PDAC) is regarded as one of the most lethal malignancies, characterized by a poor prognosis and significant resistance to conventional treatments. Although Chimeric Antigen Receptor (CAR)-T cell therapy has been considered to …
  europepmc 2026 置信度 0.80
• AND Logic Gate-Based Dual-Specificity DNA Circuit for Isothermal HBV rcDNA Detection.
  The quantitative analysis of blood HBV DNA is essential for controlling the spread of HBV and improving the prognosis of individuals infected with the virus. Yet the HBV genome exhibits complex variation, such as multiple-site mutations for entecavir resistanc…
  europepmc 2025 置信度 0.80
• Protein-inducible ribosomal frameshifting enables programmable translational control for genetic circuit design in Escherichia coli.
  Background Programmed ribosomal frameshifting (PRF) is a translational mechanism that enables the ribosome to shift reading frames and access alternative coding sequences. PRF occurs naturally in a wide range of organisms, including viruses, bacteria, and euka…
  europepmc 2026 置信度 0.80
• Logic-Gated HSV-TK/GCV Suicide Gene Circuit for Triple-Negative Breast Cancer.
  Triple-negative breast cancer (TNBC) remains a major clinical challenge, owing to its molecular complexity, therapeutic resistance, and lack of specific druggable targets. The herpes simplex virus thymidine kinase/ganciclovir (HSV-TK/GCV) suicide gene therapy …
  europepmc 2026 置信度 0.80
• Detection of single nucleotide variation diseases using DNA logic gates based on strand displacement technology
  Abstract Single-nucleotide variants (SNVs) are important for various genetic and familial diseases. Rapid and accurate detection is highly important for the early diagnosis of diseases and precise medical treatment. To address the limitations of traditional SN…
  europepmc 2026 置信度 0.80
• Intercellular CRISPRi for Distributed Genetic Circuits.
  Microbial communities and multicellular organisms employ diverse strategies for allocation of available resources, achieved through task distribution among specialized cells. Drawing inspiration from nature, several synthetic multicellular circuits have been r…
  europepmc 2026 置信度 0.80
• A reversible genetic NOR gate in plants using translational repression.
  A proof-of-concept reversible genetic logic circuit in tobacco plants is presented. The genetic circuit implements a Boolean NOR function using a Cas6-based translational repression system, with exposure to estradiol and ethanol as inputs, and expression of GF…
  europepmc 2026 置信度 0.80
• A genetically defined midbrain-pontine circuit gates vocal communication
  Vocal communication is selectively expressed in social and emotional contexts 1-3 , suggesting the presence of neural substrates that gate the conversion of internal states into vocal motor output. Although the periaqueductal gray (PAG) is known to be essentia…
  europepmc 2026 置信度 0.80
• Minimal logic gates for probiotic <i>Escherichia coli</i> Nissle 1917 sensing and treatment of dual-bacteria intestinal infection.
  Rapid development of synthetic biology has led to engineered probiotics to address the growing concern of infectious diseases and cancer. Dual or multiple bacterial infections are becoming more frequent, but there are few treatment options because complex appr…
  europepmc 2025 置信度 0.80
• Scalable multi-objective genetic algorithm for quantum circuit optimization.
  Designing compact and efficient quantum circuits that are compatible with Noisy Intermediate-Scale Quantum (NISQ) hardware remains a central challenge in quantum computing. Most existing optimization approaches rely on fidelity-based fitness functions that req…
  europepmc 2026 置信度 0.80
• Quantum-inspired logic for advanced Transcriptional Programming.
  The tenets of intelligent biological systems are (i) scalable decision-making, (ii) inheritable memory, and (iii) communication. This study aims to increase the complexity of decision-making operations beyond standard Boolean logic, while minimizing the metabo…
  europepmc 2025 置信度 0.80
• Engineering wetware and software for the predictive design of compressed genetic circuits for higher-state decision-making.
  Synthetic genetic circuits enable the reprogramming of cells, advancing the study and application of biology with greater precision. However, quantitative circuit design is hampered by the limited modularity of biological parts. As circuit complexity increases…
  europepmc 2025 置信度 0.80
• From the MMC Specification to Endosperm Cellularization in Arabidopsis: A Developmental-Handover Framework for Seed Initiation.
  Seed initiation in Arabidopsis depends on regulatory transitions that begin before fertilization, yet these events are often treated as separate developmental episodes rather than as a connected sequence. Here, we synthesize evidence from megaspore mother cell…
  europepmc 2026 置信度 0.80
• Chimeric Antigen Receptor T Cells as Living Therapeutics Targeting Senescence and Age-Related Diseases.
  The aging of the global population exacerbates the burden of age-related diseases; however, therapies that can intervene in fundamental aging processes are lacking. Senescent cells drive chronic inflammation and multitissue dysfunction through the secretion of…
  europepmc 2026 置信度 0.80
• Iterative design of a NAND hybrid riboswitch by deep batch Bayesian optimization.
  The design of large genetic circuits requires genetic regulatory devices capable of performing complex logic operations that place no excessive metabolic burden on the host cell. Hybrid riboswitches, synthetically enhanced compact RNA elements (<100 nucleotide…
  europepmc 2026 置信度 0.80
• Synthetic biology approaches to enhance cancer immune responses.
  Synthetic biology is being widely applied in tumor therapy, ranging from attenuating microbial toxicity to constructing synthetic gene circuits and developing CAR-T cells, all of which are reshaping the landscape of cancer immunotherapy. In this review, we sum…
  europepmc 2025 置信度 0.80
• Genetic designs for stochastic and probabilistic biocomputing.
  The programming of computations in living cells is achieved by manipulating information flows within genetic networks. Typically, gene expression is discretized into high and low levels, representing 0 and 1 logic values to encode a single bit of information. …
  europepmc 2025 置信度 0.80
• Engineering the holobiont: Synthetic biology strategies for reversing bioenergetic collapse in radiation enteritis.
  Radiation enteritis (RE) constitutes a catastrophic collapse of the intestinal holobiont, fundamentally constraining the curative potential of abdominopelvic radiotherapy. Current clinical management, limited by a reductionist focus on host DNA damage, often o…
  europepmc 2026 置信度 0.80