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• Optical XOR logic gate design in two dimensional photonic crystal using ANN and PSO.
  In this paper, we present an all-optical XOR gate based on two-dimensional photonic crystals (PCs). The proposed gate is designed to be used in optical computing and all-optical logic applications, offering advantages such as fast computation and parallel proc…
  europepmc 2025 置信度 0.80
• Preclinical and clinical studies on CAR-NK cell therapy: latest update from 2025 ASH Annual Meeting.
  Chimeric antigen receptor-engineered natural killer (CAR-NK) cells are emerging as an off-the-shelf immunotherapy for hematologic malignancies, supported by early clinical data and a favorable safety profile. Compared with CAR-T therapy, CAR-NK cells offer the…
  europepmc 2026 置信度 0.80
• Comment on "Innovative logic 'AND' gate gene circuits for bladder cancer treatment: preclinical study".
  europepmc 2025 置信度 0.80
• Protocell Computing on Aragonite Substrates.
  Aragonite-proteinoid microstructures are an emerging type of biocomputing material. They mix inorganic calcium carbonate with self-assembled organic proteinoid networks. Scanning electron microscopy shows a range of structures. These include isolated microsphe…
  europepmc 2026 置信度 0.80
• Safe image transmission with hybrid quantum key-genetic encryption via spatial modulation assisted NOMA.
  This manuscript presents a secure and spectrally efficient Spatial Modulation (SM)-based Non-Orthogonal Multiple Access (NOMA) system for two-user downlink 5G wireless communication. The proposed SM-NOMA shows significant improvements in spectral efficiency an…
  europepmc 2025 置信度 0.80
• Cell-free recombinase-integrated Boolean output system.
  Cell-free gene expression systems are increasingly important in fundamental research and biomanufacturing, offering a versatile platform for studying gene circuits and biocomputation. We present the cell-free recombinase-integrated Boolean output system (CRIBO…
  europepmc 2025 置信度 0.80
• RNA-Based Communication in Heterogeneous Populations of Cell Mimics.
  RNA regulators offer a promising path for building complex, orthogonal circuits due to their low resource demands and design flexibility. In this study, we explore their potential as signaling molecules in communication between synthetic cells. Specifically, w…
  europepmc 2026 置信度 0.80
• Next-generation CAR-T and CAR-NK cell therapies in hematologic malignancies: engineering for persistence, specificity, and safety.
  Chimeric antigen receptor (CAR) T-cell therapy has profoundly reshaped the therapeutic landscape for hematologic malignancies, achieving remarkable response rates in relapsed/refractory B-cell leukemias and lymphomas. Despite this success, significant challeng…
  europepmc 2026 置信度 0.80
• Supercharging the metabolic engine: mitochondrial engineering strategies for CAR-T persistence in solid tumors.
  Chimeric antigen receptor (CAR)-T cell therapy has achieved remarkable success in hematological malignancies, yet its efficacy in solid tumors is severely limited by the metabolically hostile tumor microenvironment (TME). Within this landscape, CAR-T cells und…
  europepmc 2026 置信度 0.80
• Engineering the next generation of CAR T- cells: precision modifications, logic gates and universal strategies to overcome exhaustion and tumor resistance.
  Chimeric antigen receptor (CAR) T-cell therapy has transformed the treatment landscape of hematologic malignancies, delivering durable remissions in diseases previously associated with poor outcomes. However, translating this success to solid tumors has proven…
  europepmc 2025 置信度 0.80
• AND logic-gated CRISPR/Cas9 and hybridization chain reaction system for precise ctDNA detection.
  Circulating tumor DNA (ctDNA) is a critical biomarker for liquid biopsies, enabling the non-invasive acquisition of cancer-related information from blood samples. Precise detection of ctDNA, particularly the identification of single-nucleotide variations (SNVs…
  europepmc 2025 置信度 0.80
• Molecular Stability as a Translational Gate: A Structured Framework for Target Validation in Genetic Cardiomyopathy.
  The dominant translational error in genetic cardiomyopathy is the treatment of pathogenicity annotation and mechanistic plausibility as jointly sufficient for clinical advancement, absent evidence that a target's molecular consequences are both stable and repr…
  europepmc 2026 置信度 0.80
• Solubility based mechanistic profiling of combinatorial drug therapy.
  Acute myeloid leukemia (AML) remains challenging to treat due to extensive genetic heterogeneity, high relapse rates, and treatment-related toxicity. Although drug combinations offer therapeutic promise, their selection is often empirical. Here, we introduce C…
  europepmc 2026 置信度 0.80
• Protecting cells at the genetic level and simulating unauthorized access via a biohackathon.
  The protection of high-value cell lines (assets) relies on physical security by limiting access to samples. We present a cybersecurity-inspired platform that protects biological assets at the genetic level. This technology uses a permutation lock design where …
  europepmc 2026 置信度 0.80
• CRISPR-Cas9 engineering of CAR-T cells: Can non-viral nanoparticles unlock safer and scalable genome editing?
  CAR-T cell therapy has revolutionized the treatment of hematologic malignancies. Still, durable activity in tumors remains limited by antigen heterogeneity and escape, immunosuppressive tumor microenvironment, and restricted persistence. Genome engineering wit…
  europepmc 2026 置信度 0.80
• A Modular and Customizable CRISPR/Cas Toolkit for Epigenome Editing of Cis-regulatory Modules.
  Epigenome and cis-regulome, comprising cis-regulatory elements (CREs) and modules (CRMs), jointly define the architecture of gene regulation. However, the causal mechanisms by which epigenetic marks influence CRM function remain elusive. To address this, modul…
  europepmc 2025 置信度 0.80
• Membrane Protein Insertion in Cells: Principles, Pathways, and Quality Control.
  Integral membrane proteins comprise at least a quarter of every proteome. To fold and function properly, these proteins must insert into the correct membrane with the proper topology and orientation. Although their transmembrane helices are chemically compatib…
  europepmc 2026 置信度 0.80
• Proteinoid Computing on Olivine Substrates.
  We investigate proteinoid systems formed on olivine mineral substrates, focusing on self-organization, electrochemical properties, and information-processing capacity. Olivine's ubiquity in meteorites, planetary surfaces, and protoplanetary disks makes it a ge…
  europepmc 2026 置信度 0.80
• Molecular mechanisms of phytohormone ABA-regulated anthocyanin biosynthesis in grape berry: an epigenetic dual-gating hypothesis within a five-layer regulatory framework.
  Anthocyanin biosynthesis in grape berries is a complex process regulated by the phytohormone abscisic acid, yet the molecular mechanisms underlying cultivar-specific responses and environmental memory remain poorly understood. This review proposes an "epigenet…
  europepmc 2026 置信度 0.80
• Development of a suite of activatable plant synthetic promoter systems using a bacterial LysR-type transcriptional regulator FdeR.
  Advancing plant synthetic biology requires an abundant supply of orthogonal and tunable genetic parts to express multiple genes simultaneously. Current genetic parts, particularly promoters, used in plants are still limited and often suffer from tissue specifi…
  europepmc 2026 置信度 0.80
• The renaissance of <i>Salmonella</i>-based cancer therapy: convergence of AI, synthetic circuits, and TME remodeling.
  Attenuated Salmonella has become a candidate bacterium for cancer immunotherapy, as it possesses tumor-targeting activity and is able to penetrate the hypoxic, immune-suppressive TME. However, preclinical successes were not successfully translated into early c…
  europepmc 2026 置信度 0.80
• Expanding the toolkit of LacI/GalR chimeras.
  When creating synthetic transcription circuits, multi-input regulation is desirable. However, the size and complexity of prokaryotic circuits are constrained by the number of transcription factors that can simultaneously bind a promoter region. This limitation…
  europepmc 2026 置信度 0.80
• Designing modular genetic sensors with TtgR/AcrR family transcriptional regulators by using a statistical and data-driven approach.
  Module swapping is an emerging strategy for creating transcriptional regulators with tailored combinations of signal detection and promoter recognition. By hybridizing DNA-binding modules (DBMs) and ligand-binding modules (LBMs) from the same protein family, r…
  europepmc 2025 置信度 0.80
• Immunotherapy 3.0: Breakthroughs Steering the Next Generation of Cancer Control.
  Background Hematologic disorders, including sickle cell disease, anemias, hemoglobinopathies, leukemias, lymphomas, and bleeding disorders, constitute a substantial and growing burden of morbidity and mortality across Africa. Structural health system constrain…
  europepmc 2026 置信度 0.80
• Innovative logic "AND" gate gene circuits for bladder cancer treatment: preclinical study.
  In the evolving field of precision oncology, the synthesis of gene circuits that specifically target cancer cells while preserving normal tissue marks a significant breakthrough. However, traditional approaches typically concentrate on single-gene targets, lac…
  europepmc 2025 置信度 0.80
• A regioisomer of thiazole orange derivate for selective G-Quadruplex DNA detection and in vivo tumor imaging.
  G-Quadruplex (G4) DNA structures play a crucial role in regulating various biological processes, rendering them attractive targets for diagnostic and therapeutic applications. The development of G4-targeted fluorescent probes will significantly enhance our und…
  europepmc 2026 置信度 0.80
• Nanomedicine in 2026: Illustrative Quantitative Analyses of EPR Heterogeneity, Clinical Trial Attrition, and Emerging Horizons for Active Nanotherapeutics.
  2026 is a turning point for nanomedicine, marking the field's transition from decades of preclinical promise toward tangible clinical impact. This narrative review provides a forward-oriented synthesis of the most significant clinical breakthroughs achieved du…
  europepmc 2026 置信度 0.80
• Microglial state transitions are constrained by developmental and metabolic checkpoints.
  Single-cell transcriptomic and epigenomic profiling has revealed extensive microglial heterogeneity across development, homeostasis, and disease. However, one recurring observation remains unexplained. Only subsets of microglia adopt expected transcriptional p…
  europepmc 2026 置信度 0.80
• Design, construction, and field evaluation of an intelligent solid-state voltage regulator for voltage profile improvement in low-voltage distribution networks.
  Voltage drop at the end of low-voltage (LV) feeders is one of the major operational challenges in distribution networks, often leading to reduced power quality and malfunction of sensitive loads. Conventional distribution transformers equipped with mechanical …
  europepmc 2026 置信度 0.80
• Chimeric antigen receptor technology: an emerging translational immunotherapy in nonneoplastic diseases.
  Background One of the most significant recent advancements in cancer immunotherapy is the development of chimeric antigen receptor (CAR) technology. More recently, this approach has been gradually modified for the research associated with various treatment-res…
  europepmc 2026 置信度 0.80
• Architectures, Protocols and Algorithms of Sensor Networks-Second Edition.
  Sensor networks have become a background technology for a wide range of applications in industrial automation, smart cities, intelligent transportation systems, healthcare monitoring, environmental sensing, precision agriculture, and supervision of critical in…
  europepmc 2026 置信度 0.80
• PSMA-directed CAR-T cell therapy for metastatic castration-resistant prostate cancer: a next-generation engineering perspective on stem cell-derived immune effectors.
  The clinical translation of prostate-specific membrane antigen (PSMA)-directed chimeric antigen receptor (CAR) T-cell therapy for metastatic castration-resistant prostate cancer (mCRPC) has reached a critical impasse. Despite compelling preclinical rationale a…
  europepmc 2026 置信度 0.80
• Research progress and future perspectives in proteolysis-targeting chimeras.
  Proteolysis-targeting chimeras (PROTACs) have emerged as a transformative modality within the targeted protein degradation (TPD) landscape, inducing spatial proximity between E3 ubiquitin ligases and proteins of interest (POIs) to hijack the ubiquitin-proteaso…
  europepmc 2026 置信度 0.80
• From association to causation: a decision-aware framework for reproducible biomarker discovery and precision intervention design in the human gut microbiome.
  Human gut microbiome research has generated many disease associations, yet few translate into clinical applications. A central obstacle is not a lack of data, but the limited integration of causal reasoning, as most studies report correlations without establis…
  europepmc 2026 置信度 0.80
• Logic-Gated DNA Production Line for Cancer Cell Recognition and Intracellular Cascaded Gene Therapy.
  Tumor-derived biomarkers can precisely reflect cell types, offering major potential for early detection and therapy. An engineered platform capable of distinguishing various biomarkers for cancer type identification and autonomous responsive therapeutics is ur…
  europepmc 2025 置信度 0.80
• Multi-mechanism-driven dual-mode array based on a single PFC-1/QD probe enables AI-assisted on-site identification of biogenic amines and real-time food freshness monitoring.
  Biogenic amines (BAs) serve as critical indicators of food spoilage, necessitating portable and real-time monitoring approaches to ensure food safety. To this end, we developed a P-QDot-based fluorescence/colorimetric (FL/CL) dual-mode sensor array integrated …
  europepmc 2026 置信度 0.80
• Implementation of double Feynman gate in high dimensional quantum systems.
  The photonic platform has emerged as a preferred choice for quantum computing and information processing due to its low loss and high integration capabilities. In the present research, we propose a high-dimensional double Feynman gate utilizing single-photon h…
  europepmc 2025 置信度 0.80
• Energy Aware Technology Mapping of Genetic Logic Circuits.
  Energy and its dissipation are fundamental to all living systems, including cells. Insufficient abundance of energy carriers─as caused by the additional burden of artificial genetic circuits─shifts a cell's priority to survival, also impairing the functionalit…
  europepmc 2024 置信度 0.80
• Mammalian synthetic gene circuits for biopharmaceutical development & manufacture.
  This paper reviews the design and application of mammalian synthetic gene circuits for biopharmaceutical manufacturing. It discusses key design principles and outlines transcription factors, DNA-binding proteins, and RNA as input and regulatory modules, while …
  europepmc 2025 置信度 0.80
• Shifting Beyond Classical Drug Synergy in Combinatorial Therapy through Solubility Alterations
  Abstract Acute myeloid leukemia (AML) remains a formidable clinical challenge due to genetic heterogeneity, high relapse rates, and toxicities associated with conventional chemotherapies. Rationally designed drug combinations offer improved efficacy, yet their…
  europepmc 2024 置信度 0.80
• The trinity of T cell engagement: navigating the molecular and clinical landscape of CAR-T, TILs, and TCEs in the war against cancer.
  The advent of cancer immunotherapy has fundamentally restructured the oncological paradigm, moving away from agents that directly target tumor cell kinetics toward strategies that empower the host immune system to recognize and eliminate malignancy. Central to…
  europepmc 2026 置信度 0.80
• Evolvable AI: Threats of a new major transition in evolution.
  Evolvable AI (eAI), i.e., AI systems whose components, learning rules, and deployment conditions can themselves undergo Darwinian evolution, may soon emerge from current trends in generative, agentic, and embodied AI. We argue that this possibility has been un…
  europepmc 2026 置信度 0.80
• Methyltransferase Detection Based on Target-Responsive Transcription Amplification of Light-Up Aptamer.
  The sensitive and accurate evaluation of DNA methyltransferases (MTases) is essential for biomedical and synthetic biology applications. However, existing approaches have limited applications because they are labor-intensive with low sensitivity, require sophi…
  europepmc 2025 置信度 0.80
• Conditional guide RNA deactivation by mRNA and small molecule triggers in Saccharomyces cerevisiae.
  CRISPR interference (CRISPRi) technologies have revolutionized bioengineering by providing precise tools for gene expression modulation, enabling targeted gene perturbation and metabolic pathway optimization. Despite these advances, achieving dynamic control o…
  europepmc 2025 置信度 0.80
• Amplifying Genetic Logic Gates
  Organisms must process information encoded via developmental and environmental signals to survive and reproduce. Researchers have also engineered synthetic genetic logic to realize simpler, independent control of biological processes. We developed a three-term…
  openalex J. Bonnet, Peter Yin, Monica E. Ortiz, Pakpoom Subsoontorn 等 2013-03-29 置信度 0.72 TransistorRecombinaseLogic gatePass transistor logicComputer science
• Detection of pathological biomarkers in human clinical samples via amplifying genetic switches and logic gates
  Whole-cell biosensors have several advantages for the detection of biological substances and have proven to be useful analytical tools. However, several hurdles have limited whole-cell biosensor application in the clinic, primarily their unreliable operation i…
  openalex Alexis Courbet, Drew Endy, Éric Renard, Franck Molina 等 2015-05-27 置信度 0.72 PathologicalBiologyMedicinePathology
• Genetic Logic Gates Enable Patterning of Amyloid Nanofibers
  Distinct spatial patterning of naturally produced materials is observed in many cellular structures and even among communities of microorganisms. Reoccurrence of spatially organized materials in all branches of life is clear proof that organization is benefici…
  openalex Ebuzer Kalyoncu, Recep Erdem Ahan, Cemile Elif Özçelik, Urartu Özgür Şafak Şeker 2019-08-12 置信度 0.72 NanotechnologyMaterials scienceNanofiberRecombinaseBiology
• Construction of Genetic Logic Gates Based on the T7 RNA Polymerase Expression System in <i>Rhodococcus opacus</i> PD630
  Rhodococcus opacus PD630 ( R. opacus ) is a nonmodel, Gram-positive bacterium that holds promise as a biological catalyst for the conversion of lignocellulosic biomass to value-added products. In particular, it demonstrates both a high tolerance for and an abi…
  openalex Drew M. DeLorenzo, Tae Seok Moon 2019-07-30 置信度 0.72 Synthetic biologyBiologyRhodopseudomonas palustrisGeneBiochemistry
• Robust multicellular computing using genetically encoded NOR gates and chemical ‘wires’
  openalex Alvin Tamsir, Jeffrey J. Tabor, Christopher A. Voigt 2010-12-08 置信度 0.72 Synthetic biologyModular designComputer scienceMulticellular organismScalability
• Establishing Tunable Genetic Logic Gates with Versatile Dynamic Performance by Varying Regulatory Parameters
  High Resolution Image Download MS PowerPoint Slide Genetic logic gates can be employed in metabolic engineering and synthetic biology to regulate gene expression based on diverse inputs. Design of tunable genetic logic gates with versatile dynamic performance …
  openalex Tian Jiang, Yuxi Teng, Chenyi Li, Qi Gan 等 2023-11-30 置信度 0.72 Synthetic biologyLogic gateAND gateComputer scienceComputational biology
• A Synthetic Genetic Edge Detection Program
  openalex Jeffrey J. Tabor, Howard M. Salis, Zachary Booth Simpson, Aaron Chevalier 等 2009-06-01 置信度 0.72 BiologySIGNAL (programming language)Synthetic biologyParameterized complexityComputation
• Kernel P Systems and Stochastic P Systems for Modelling and Formal Verification of Genetic Logic Gates
  openalex Marian Gheorghe, Savas Konur, Florentin Ipate 2016-07-18 置信度 0.72 Computer scienceMembrane computingTheoretical computer scienceKernel (algebra)Natural computing
• Construction and Enhancement of a Minimal Genetic AND Logic Gate
  The ability of genetic networks to integrate multiple inputs in the generation of cellular responses is critical for the adaptation of cellular phenotype to distinct environments and of great interest in the construction of complex artificial circuits. To deve…
  openalex Daniel J. Sayut, Yan D. Niu, Lianhong Sun, Yan Niu 2008-12-06 置信度 0.72 Synthetic biologyBiologyMutantRepressorGene
• Rapid engineering of versatile molecular logic gates using heterologous genetic transcriptional modules
  We designed and constructed versatile modular genetic logic gates in bacterial cells. These function as digital logic 1-input Buffer gate, 2-input and 3-input AND gates with one inverted input and integrate multiple chemical input signals in customised logic m…
  openalex Baojun Wang, Martin Buck 2014-01-01 置信度 0.72 Modular designEscherichia coliSynthetic biologyLogic gateComputational biology
• A modular cell-based biosensor using engineered genetic logic circuits to detect and integrate multiple environmental signals
  Cells perceive a wide variety of cellular and environmental signals, which are often processed combinatorially to generate particular phenotypic responses. Here, we employ both single and mixed cell type populations, pre-programmed with engineered modular cell…
  openalex Baojun Wang, Mauricio Barahona, Martin Buck 2012-08-23 置信度 0.72 Synthetic biologyBiosensorModular designComputer scienceNanotechnology
• Realizing logic gates with time-delayed synthetic genetic networks
  openalex Amit Sharma, Vivek Kohar, Manish Dev Shrimali, Sudeshna Sinha 2013-11-15 置信度 0.72 Realization (probability)Logic gatePass transistor logicComputer scienceAND-OR-Invert
• Synthetic circuits integrating logic and memory in living cells
  openalex Piro Siuti, John Yazbek, Timothy K. Lu 2013-02-10 置信度 0.72 Computer scienceSynthetic biologySequential logicRecombinaseLogic gate
• Digital logic circuits in yeast with CRISPR-dCas9 NOR gates
  Natural genetic circuits enable cells to make sophisticated digital decisions. Building equally complex synthetic circuits in eukaryotes remains difficult, however, because commonly used components leak transcriptionally, do not arbitrarily interconnect or do …
  openalex Miles Gander, Justin D. Vrana, William E. Voje, James M. Carothers 等 2017-05-25 置信度 0.72 Computer scienceCRISPRSynthetic biologyElectronic circuitLogic gate
• Genomic mining of prokaryotic repressors for orthogonal logic gates
  openalex Brynne C. Stanton, Alec A. K. Nielsen, Alvin Tamsir, Kevin Clancy 等 2013-12-08 置信度 0.72 TetRPromoterRepressorSynthetic biologyComputational biology
• Plasticity of the truth table of low-leakage genetic logic gates
  The design and implementation of genetic logic gates is a fundamental component of biological computation. In this article we show that the function of a common class of synthetic genetic AND and NAND gates is not completely dictated by the circuit connectivit…
  openalex Stewart Smith, Ramon Grima 2018-12-21 置信度 0.72 NAND gateLogic gateLeakage (economics)AND gateNOR logic
• Bistability, Epigenetics, and Bet-Hedging in Bacteria
  Clonal populations of microbial cells often show a high degree of phenotypic variability under homogeneous conditions. Stochastic fluctuations in the cellular components that determine cellular states can cause two distinct subpopulations, a property called bi…
  openalex Jan‐Willem Veening, Wiep Klaas Smits, Oscar P. Kuipers 2008-06-06 置信度 0.72 EpigeneticsBistabilityBiologyPhenotypeInheritance (genetic algorithm)
• Chaotic logic gate: A new approach in set and design by genetic algorithm
  openalex Mahmood Beyki, Mahdi Yaghoobi 2015-06-23 置信度 0.72 Tournament selectionFitness proportionate selectionChaoticLogistic mapComputer science
• Multi‐input CRISPR/Cas genetic circuits that interface host regulatory networks
  Genetic circuits require many regulatory parts in order to implement signal processing or execute algorithms in cells. A potentially scalable approach is to use dCas9, which employs small guide RNAs (sgRNAs) to repress genetic loci via the programmability of R…
  openalex Alec AK Nielsen, Christopher A. Voigt 2014-11-01 置信度 0.72 Synthetic biologyBiologyCRISPRElectronic circuitComputational biology
• Co-opting signalling molecules enables logic-gated control of CAR T cells
  openalex Aidan M. Tousley, Maria Caterina Rotiroti, Louai Labanieh, Lea Wenting Rysavy 等 2023-03-08 置信度 0.72 Chimeric antigen receptorSignallingGatingCell biologyT cell
• Orthogonally modulated molecular transport junctions for resettable electronic logic gates
  Individual molecules have been demonstrated to exhibit promising applications as functional components in the fabrication of computing nanocircuits. Based on their advantage in chemical tailorability, many molecular devices with advanced electronic functions h…
  openalex Fanben Meng, Yves‐Marie Hervault, Qi Shao, Benhui Hu 等 2014-01-07 置信度 0.72 Molecular electronicsLogic gateNanotechnologyElectronic circuitMaterials science
• Synthesizing a novel genetic sequential logic circuit: a push‐on push‐off switch
  Design and synthesis of basic functional circuits are the fundamental tasks of synthetic biologists. Before it is possible to engineer higher-order genetic networks that can perform complex functions, a toolkit of basic devices must be developed. Among those d…
  openalex Chunbo Lou, Xili Liu, Ming Ni, Yi-Qi Huang 等 2010-03-09 置信度 0.72 BistabilitySequential logicElectronic circuitSynthetic biologyComputer science
• Semibiological Molecular Machine with an Implemented “AND” Logic Gate for Regulation of Protein Folding
  A semibiological molecular machine with an implemented "AND" logic gate was developed, which was capable of controlling the folding process of proteins in response to ATP and light as input stimuli. The molecular design made use of a genetically engineered cha…
  openalex Shin‐ichi Muramatsu, Kazushi Kinbara, Hideki Taguchi, Noriyuki Ishii 等 2006-02-25 置信度 0.72 ChemistryFolding (DSP implementation)Molecular machineBiophysicsComputational biology
• A population‐based temporal logic gate for timing and recording chemical events
  Engineered bacterial sensors have potential applications in human health monitoring, environmental chemical detection, and materials biosynthesis. While such bacterial devices have long been engineered to differentiate between combinations of inputs, their pot…
  openalex Victoria Hsiao, Yutaka Hori, Paul W. K. Rothemund, Richard M. Murray 2016-05-01 置信度 0.72 ENCODEPopulationTemporal logicBiologySynthetic biology
• Synthesizing AND gate genetic circuits based on CRISPR-Cas9 for identification of bladder cancer cells
  openalex Yuchen Liu, Yayue Zeng, Li Liu, Chengle Zhuang 等 2014-11-06 置信度 0.72 CRISPRBiologyComputational biologyTelomerase reverse transcriptaseCas9
• Environmental signal integration by a modular AND gate
  Microorganisms use genetic circuits to integrate environmental information. We have constructed a synthetic AND gate in the bacterium Escherichia coli that integrates information from two promoters as inputs and activates a promoter output only when both input…
  openalex J. Christopher Anderson, Christopher A. Voigt, Adam P. Arkin 2007-08-14 置信度 0.72 BiologyPromoterSynthetic biologyT7 RNA polymeraseTranscription (linguistics)
• Realizing the transformation of logic gates in a genetic toggle system under Lévy noise
  openalex Juan Wu, Yong Xu, Shaojuan Ma 2019-01-08 置信度 0.72 AND-OR-InvertLogic gatePass transistor logicNAND gateNAND logic
• Permanent genetic memory with &gt;1-byte capacity
  openalex Lei Yang, Alec A. K. Nielsen, Jesús Fernández-Rodríguez, Conor J. McClune 等 2014-10-26 置信度 0.72 RecombinaseIntegrasesCre recombinaseByteDNA
• Logic‐Gate‐Actuated DNA‐Controlled Receptor Assembly for the Programmable Modulation of Cellular Signal Transduction
  Programming cells to sense multiple inputs and activate cellular signal transduction cascades is of great interest. Although this goal has been achieved through the engineering of genetic circuits using synthetic biology tools, a nongenetic and generic approac…
  openalex Shan Chen, Zhifei Xu, Wen Yang, Xiahui Lin 等 2019-10-09 置信度 0.72 Signal transductionAptamerModular designSynthetic biologyTransduction (biophysics)
• G-quadruplexes for luminescent sensing and logic gates
  G-quadruplexes represent a versatile sensing platform for the construction of label-free molecular detection assays owing to their diverse structures that can be selectively recognized by G-quadruplex-specific luminescent probes. In this Survey and Summary, we…
  openalex H.-Z. He, D. S.-H. Chan, Chung‐Hang Leung, Dik‐Lung Ma 2013-02-23 置信度 0.72 BiologyG-quadruplexLuminescenceComputational biologyDNA
• Maximum power point tracking using a GA optimized fuzzy logic controller and its FPGA implementation
  openalex A. Messai, A. Mellit, A. Guessoum, Soteris A. Kalogirou 2011-01-05 置信度 0.72 VHDLField-programmable gate arrayMaximum power point trackingPhotovoltaic systemComputer science
• Optimization of Combinational Logic Circuits Using NAND Gates and Genetic Programming
  openalex Arezoo Rajaei, Mahboobeh Houshmand, Modjtaba Rouhani 2011-01-01 置信度 0.72 NAND gateCombinational logicNAND logicAND-OR-InvertLogic gate
• Bankers at the gate: Microfinance and the high cost of borrowed logics
  openalex Derin Kent, M. Tina Dacin 2013-05-17 置信度 0.72 MicrofinanceMicroinsuranceEconomicsBusinessFinancial system
• Design, Fabrication, and Device Chemistry of a 3-Input-3-Output Synthetic Genetic Combinatorial Logic Circuit with a 3-Input AND Gate in a Single Bacterial Cell
  Advancement of in-cell molecular computation requires multi-input-multi-output genetic logic devices. However, increased physical size, a higher number of molecular interactions, cross-talk, and complex systems level device chemistry limited the realization of…
  openalex Deepro Bonnerjee, Sayak Mukhopadhyay, Sangram Bagh 2019-10-09 置信度 0.72 Logic gateAND gateSynthetic biologyTruth tableRealization (probability)
• Genetic algorithm based logic optimization for multi- output majority gate-based nano-electronic circuits
  The majority-gate and the inverter-gate together make a universal set of Boolean primitives in quantum-dot cellular automata (QCA) circuits. An important step in designing QCA circuits is reducing the number of required primitives to implement a given Boolean …
  openalex Monireh Houshmand, Saied Hosseini Khayat, Razie Rezaei 2009-11-01 置信度 0.72 Boolean functionBoolean circuitCircuit minimization for Boolean functionsLogic gateComputer science
• Programmable single-cell mammalian biocomputers
  openalex Simon Ausländer, David M. Auslander, Marius Müller, Markus Wieland 等 2012-06-01 置信度 0.72 Synthetic biologyComputer scienceRobustness (evolution)NAND gateCombinational logic
• The Q System: A Repressible Binary System for Transgene Expression, Lineage Tracing, and Mosaic Analysis
  openalex Christopher J. Potter, Bosiljka Tasic, Emilie V. Russler, Liang Liang 等 2010-04-01 置信度 0.72 BiologyTransgeneGeneticsMosaicExpression (computer science)
• A Framework for Genetic Logic Synthesis
  Digital electronic circuits have inspired synthetic biologists to program living cells with synthetic decision-making circuits by creating multilevel genetic logic gates. In both genetic and electronic circuits, logic synthesis translates an abstract functiona…
  openalex Prashant Vaidyanathan, Bryan S. Der, Swapnil Bhatia, Nicholas Roehner 等 2015-08-18 置信度 0.72 Computer scienceDigital electronicsLogic synthesisLogic gateRepresentation (politics)
• To go or not to go? Biological logic gating engineered T cells
  Genetically engineered T cells have been successfully used in the treatment of hematological malignancies, greatly increasing both progression-free and overall survival in patients. However, the outcomes of patients treated with Chimeric Antigen Receptor (CAR)…
  openalex Rebecca C Abbott, Hannah E Hughes‐Parry, Misty R. Jenkins 2022-04-01 置信度 0.72 Chimeric antigen receptorGatingTumor microenvironmentAntigenCancer research
• SynBioLGDB: a resource for experimentally validated logic gates in synthetic biology
  Synthetic biologists have developed DNA/molecular modules that perform genetic logic operations in living cells to track key moments in a cell's life or change the fate of a cell. Increasing evidence has also revealed that diverse genetic logic gates capable o…
  openalex Liqiang Wang, Kun Qian, Yan Huang, Nana Jin 等 2015-01-28 置信度 0.72 Computer scienceLogic gateSynthetic biologyNOR logicAND gate
• Design and Analysis of Genetically Constructed Logic Gates
  Synthetic biology, comprising many aspects including in vivo, in vitro and in silico techniques, models and methods, programming paradigms and tools, is a rapidly growing field with promising potential in building new synthetically constructed devices and syst…
  openalex Savas Konur, Marian Gheorghe 2015-02-11 置信度 0.72 Synthetic biologyWorkbenchIn silicoComputer scienceGenetic programming
• Designable DNA-binding domains enable construction of logic circuits in mammalian cells
  openalex Rok Gaber, Tina Lebar, Andreja Majerle, Branko Šter 等 2014-01-12 置信度 0.72 Logic gateSynthetic biologyElectronic circuitComputer scienceModular design
• Evolution of a designless nanoparticle network into reconfigurable Boolean logic
  openalex Saurabh K. Bose, Celestine Lawrence, Zhi‐Hong Liu, Ksenia S. Makarenko 等 2015-09-21 置信度 0.72 Computer scienceScalabilityExploitUnconventional computingRobustness (evolution)
• Designer Genetic Algorithms: Genetic Algorithms in Structure Design.
  This paper considers the problem of using genetic algorithms to design structures. We relax one constraint on classical genetic algorithms and describe a genetic algorithm that uses differential information about search direction to design structures. This dif…
  openalex Sushil J. Louis, Gregory J. E. Rawlins 1991-01-01 置信度 0.72 AlgorithmComputer scienceGenetic algorithmQuality control and genetic algorithmsMeta-optimization
• Genetic circuit design automation with Cello 2.0
  openalex Timothy S. Jones, Samuel M. D. Oliveira, Chris J. Myers, Christopher A. Voigt 等 2022-02-23 置信度 0.72 CelloAutomationComputational biologyComputer scienceElectronic design automation
• Genetic Optimization of the Y-Shaped Photonic Crystal NOT Logic Gate
  The present paper is devoted to the actual problem of photonic crystal (PhC) logic gate design. The development of components for photonic digital computing systems will provide opportunities for high-efficient information processing. The use of 2D photonic cr…
  openalex Vladimir Pavelyev, Yuliana Krivosheeva, Dimitriy L. Golovashkin 2023-10-21 置信度 0.72 XOR gatePhotonic crystalLogic gateInterference (communication)Computer science
• Pyruvate-responsive genetic circuits for dynamic control of central metabolism
  openalex Xianhao Xu, Xueliang Li, Yanfeng Liu, Yong-Lian Zhu 等 2020-09-07 置信度 0.72 Synthetic biologyBacillus subtilisMetabolic pathwayMetabolismIntracellular
• Creating morphable logic gates using logical stochastic resonance in an engineered gene network
  The idea of Logical Stochastic Resonance is adapted and applied to an autoregulatory gene network in the bacteriophage λ. This biological logic gate can emulate or morph the AND and OR gates, through varying internal system parameters, in a noisy background. S…
  openalex A. Dari, Behnam Kia, Adi R. Bulsara, William L. Ditto 2011-01-01 置信度 0.72 Logic gateRealization (probability)NOR logicGene regulatory networkSynthetic biology
• The role of enhancers in cancer
  openalex Inderpreet Sur, Jussi Taipale 2016-07-01 置信度 0.72 EnhancerBiologyEpigeneticsTranscription factorGene
• Engineering Complex Riboswitch Regulation by Dual Genetic Selection
  The recent discovery of riboswitches in diverse species of bacteria and few eukaryotes added metabolite-responsive gene regulation to the growing list of RNA functions in biology. The natural riboswitches have inspired several designs of synthetic analogues ca…
  openalex Vandana Sharma, Yoko Nomura, Yohei Yokobayashi 2008-11-08 置信度 0.72 RiboswitchSynthetic biologyComputational biologyAptamerRNA
• Inverse design of ultra-compact optical logic gates by genetic algorithm
  openalex Yunlei Lan, Daxing Li, H. Kai, Bin Zou 等 2024-06-15 置信度 0.72 InverseOpticsGenetic algorithmComputer scienceInverse problem
• Combinational logic synthesis for LUT based field programmable gate arrays
  The increasing popularity of the field programmable gate-array (FPGA) technology has generated a great deal of interest in the algorithmic study and tool development for FPGA-specific design automation problems. The most widely used FPGAs are LUT based FPGAs, …
  openalex Jason Cong, Yuzheng Ding 1996-04-01 置信度 0.72 Computer scienceLookup tableField-programmable gate arrayCombinational logicProgrammable logic array
• Construction of a genetic AND gate under a new standard for assembly of genetic parts
  BACKGROUND: Appropriate regulation of respective gene expressions is a bottleneck for the realization of artificial biological systems inside living cells. The modification of several promoter sequences is required to achieve appropriate regulation of the syst…
  openalex Shotaro Ayukawa, Akio Kobayashi, Yusaku Nakashima, Hidemasa Takagi 等 2010-12-01 置信度 0.72 Operator (biology)BiologyComputational biologyPlasmidBottleneck
• Contextual dependencies expand the re-usability of genetic inverters
  The implementation of Boolean logic circuits in cells have become a very active field within synthetic biology. Although these are mostly focussed on the genetic components alone, the context in which the circuit performs is crucial for its outcome. We charact…
  openalex Hüseyin Taş, Lewis Grozinger, Ruud Stoof, Vı́ctor de Lorenzo 等 2021-01-13 置信度 0.72 Computer scienceSoftware portabilitySynthetic biologyLogic gateUsability
• Programming CAR T Cell Tumor Recognition: Tuned Antigen Sensing and Logic Gating
  The success of chimeric antigen receptor (CAR) T cells targeting B-cell malignancies propelled the field of synthetic immunology and raised hopes to treat solid tumors in a similar fashion. Antigen escape and the paucity of tumor-restricted CAR targets are rec…
  openalex Mohamad Hamieh, Jorge Mansilla‐Soto, Isabelle Rivière, Michel Sadelain 2023-03-24 置信度 0.72 Chimeric antigen receptorAntigenT-cell receptorImmunotherapyT cell
• A Genetic Algorithm Based Logic Optimization for Majority Gate-Based QCA Circuits in Nanoelectronics
  openalex Arman Roohi, Babak Menbari, Ebrahim Shahbazi, Mohsen Kamrani 2013-04-26 置信度 0.72 NanoelectronicsElectronic circuitLogic gateComputer scienceGenetic algorithm