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ABSTRACT In vitro transcription (IVT) systems regulated by allosteric transcription factors (aTFs) are central to emerging cell-free biosensing and synthetic biology platforms, yet their performance is often limited by suboptimal protein–DNA interactions and t…
preprints
2026
置信度 0.74
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Implementing logic functions in living cells is a fundamental area of interest among synthetic biologists. The goal of designing biochemical circuits in synthetic biology is to make modular and tractable systems that perform well with predictable behaviors. De…
europepmc
2025
置信度 0.80
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Programmable organoids are emerging as a powerful new class of engineered developmental systems in which genetic circuits, epigenetic memory architectures, synthetic organizers, and closed-loop control frameworks converge to enable precise regulation of morpho…
preprints
2025
置信度 0.74
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ABSTRACT Macrophages are abundant immune cells within the tumor microenvironment with intrinsic phagocytic capabilities, yet their antitumor functions are frequently suppressed by inhibitory signals. Synthetic biology enables the rational design of ligand-resp…
preprints
2026
置信度 0.74
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ABSTRACT Plant-derived pigments offer sustainable alternatives to synthetic colorants, yet their practical deployment in textiles is limited by restricted chemical diversity and low abundance. Liverworts represent a source of diverse chemical compounds, and th…
preprints
2026
置信度 0.74
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Synthetic biology is undergoing a pivotal shift from single-species engineering to rational design of synthetic microbial consortia, enabling more complex, efficient, and resilient functionalities. This transition responds to the growing demand for microbial a…
preprints
2025
置信度 0.74
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Synthetic biology aims to engineer or re-engineer living systems. To achieve increasingly complex functionalities, it is beneficial to use higher-level building blocks. In this study, we focus on oscillators as such building blocks, propose novel oscillator-ba…
preprints
2025
置信度 0.74
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Nucleic acid circuits are powerful tools for programming biology, but the design principles for operating these circuits in complex cellular environments remain poorly understood compared to simple in vitro settings. Cell-free expression systems (CFES) are uni…
preprints
2025
置信度 0.74
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ABSTRACT Precise control of gene expression is one of the fundamental goals of synthetic biology. Whether the objective is to modify endogenous cellular function or induce the expression of molecules for diagnostic and therapeutic purposes, gene regulation rem…
preprints
2025
置信度 0.74
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Temperature offers a simple yet powerful signal to program cellular behavior. Here, we engineered and characterized a set of temperature-dependent genetic circuits that integrate RNA thermometers with site-specific DNA recombinases to achieve precise, irrevers…
preprints
2025
置信度 0.74
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Gene regulatory networks (GRNs) govern processes such as cell fate, patterning, and adaptation. While multistability and oscillations are both common GRN dynamics in cell biology, they are typically studied and engineered in isolation. Here, we challenge this …
preprints
2025
置信度 0.74
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The soil dwelling bacteria Streptomyces is an abundant producer of numerous anticancer, antifungal, and antibiotic compounds (i.e. Natural Products, NPs). The sophisticated cellular machinery required to produce NPs is frequently regulated by quorum-sensing sy…
preprints
2025
置信度 0.74
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Metabolic engineering of mesenchymal stem/stromal cells (MSCs) represents a compelling frontier for advanced cellular therapies, enabling the precise tuning of their biological outputs. This feature paper examines the critical role of engineered culture microe…
preprints
2025
置信度 0.74
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Recent advances in generative artificial intelligence have begun to redefine the practice of cell and immune engineering. By learning the statistical and structural grammar of biological systems, generative models can now design T-cell receptors, chimeric anti…
preprints
2025
置信度 0.74
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Genetic circuits are a cornerstone of synthetic biology, enabling programmable control of cellular behavior for applications in health, sustainability, and biotechnology. While Genetic Design Automation (GDA) tools have optimized and streamlined the design of …
preprints
2025
置信度 0.74
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Abstract Background Chimeric antigen receptor (CAR)-based immunotherapies face significant translational challenges in solid tumor applications, particularly regarding manufacturing scalability, tumor targeting specificity, and antigen heterogeneity. This syst…
preprints
2025
置信度 0.74
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Plant synthetic biology holds great promise for engineering plants to meet future demands. Genetic circuits are being designed, built, and tested in plants to demonstrate proof of concept. However, developing these components in monocots, which the world relie…
preprints
2025
置信度 0.74
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Abstract Synthetic biology offers a novel paradigm to reprogram gene expression using synthetic chromatin circuits. The current theoretical framework aims to describe modeling of synthetic chromatin circuits operating against oncogenic TFs in order to modulate…
preprints
2025
置信度 0.74
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Adaptive, closed-loop control of cellular behavior is essential for next-generation therapies, yet most current treatments operate in an open-loop manner and lack robustness to patient variability and disease dynamics. Here, we establish a controltheoretic pla…
preprints
2026
置信度 0.74
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Controlling cell population dynamics and phenotypic diversification is a key objective in systems and synthetic biology, particularly for ensuring uniform responses from engineered gene circuits. While cell-machine interfaces have been employed to modulate hos…
preprints
2025
置信度 0.74
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ABSTRACT Cellular decision-making relies heavily on bistable gene regulatory networks, which allow systems to respond to internal or external stimuli by switching between several stable expression states. Processes like cell differentiation, epigenetic memory,…
preprints
2025
置信度 0.74
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Quantum biology is an emergent field that investigates quantum-mechanical phenomena, such as superposition, tunneling, and entanglement, in the context of data manipulation from living systems. The exploration and engineering of nucleotide sequences rely on qu…
preprints
2025
置信度 0.74
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Standardized methods for the assembly of DNA constructs have become indispensable in synthetic biology, biotechnology and basic research. The majority of frameworks – most prominently based on Golden Gate – have been developed and optimized for the assembly of…
preprints
2025
置信度 0.74
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ABSTRACT Programmed −1 ribosomal frameshifting (−1 PRF) is a recoding mechanism utilized by viruses to expand their coding capacity and modulate the stoichiometric ratio of −1 frame and 0 frame translation products. The stability of mRNA secondary structure at…
preprints
2025
置信度 0.74
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Training physical neural networks directly in matter remains difficult because most platforms do not store and update weights within the same physical substrate. Here we show that engineered Escherichia coli can implement a genetically encoded local learning r…
europepmc
2026
置信度 0.80
-
Tracking prey or recognizing a lurking predator is as crucial for survival as anticipating their actions. To guide behavior, the brain must extract information about object identities and their dynamics from entangled sensory inputs. How it accomplishes this f…
preprints
2025
置信度 0.74
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Photosynthetic efficiency in crops is a major limiting factor in agricultural productivity and climate resilience. Synthetic biology provides novel approaches to reprogram photosynthesis by engineering carbon fixation pathways, optimizing RuBisCO efficiency, a…
preprints
2025
置信度 0.74
-
Understanding the neuromuscular basis for behavior requires measuring both kinematic and physiological data at high resolution in unconstrained conditions: a technically challenging goal. Here we present an integrated experimental-computational pipeline for me…
preprints
2026
置信度 0.74
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ABSTRACT Recombinases are versatile enzymes able to perform the precise insertion, deletion, and rearrangement of DNA and can act as a foundation for programmable genetic logic and memory. Fundamental to their use are accurate measurements of function. However…
preprints
2025
置信度 0.74
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Glioblastoma multiforme (GBM) remains one of the most aggressive and treatment-resistant brain tumors, characterized by a hostile microenvironment and poor prognosis. Recent advances in synthetic biology have led to the engineering of Escherichia coli (E. coli…
preprints
2025
置信度 0.74
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Living systems have evolved cognitive complexity to reduce environmental uncertainty, enabling them to predict and prepare for future conditions. Anticipation, distinct from simple prediction, involves active adaptation before an event occurs and is a key feat…
preprints
2025
置信度 0.74
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Effective neural regeneration and realistic brain-on-a-chip platforms demand transformative methodologies capable of dynamically adapting their mechanical, electrical, and biochemical environments in synchrony with resident neural tissues. Recent innovations i…
preprints
2025
置信度 0.74
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Catalytic molecular templating, wherein a copolymer molecule serves as a sequence-specific template to propagate genetic information to a daughter copolymer, is fundamental to cells. Templating underlies DNA replication, RNA transcription and protein translati…
europepmc
2026
置信度 0.80
-
Programmable DNA devices represent a transformative frontier in biosensing technology, offering unprecedented precision, adaptability, and miniaturization. These devices—ranging from DNA nanostructures and aptamer-based sensors to gene circuits and DNA strand …
preprints
2025
置信度 0.74
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This work explores the integration of machine learning (ML) and mechanistic models (MM). While ML has demonstrated remarkable success in data-driven modeling across engineering, biology, and other scientific fields, MM remain essential for their interpretabili…
preprints
2025
置信度 0.74
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Transcription factors (TFs) regulate gene expression by binding cis-regulatory DNA elements, yet how trans-regulatory characteristics such as TF affinity, concentration, and localization interact with cis-regulatory elements remains largely unclear. We systema…
preprints
2026
置信度 0.74
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Biomolecular integral feedback controllers offer precise regulation of molecular species copy numbers, making them valuable for synthetic biology applications. Antithetic integral feedback controllers, in particular, can be effective in low-copy-number regimes…
preprints
2025
置信度 0.74
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Modeling and simulating gene regulatory networks (GRNs) is crucial for understanding biological processes, predicting system behavior, guiding the design of synthetic biological systems, and interpreting experimental data. In synthetic biology, GRNs play a piv…
preprints
2024
置信度 0.74
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While secretion plays a key role in the diverse applications of cell engineering, to date only a handful of mammalian signal peptides have been characterised in depth and systematic efforts to build novel variants remain sporadic. We present STAMPS (Signal-pep…
preprints
2025
置信度 0.74
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Developing logic gate circuits that are programmable and reliable for specific functions is a central goal in synthetic biology. Traditional synthetic circuits often rely on protein regulators, which face scalability and resource burden limitations. To overcom…
preprints
2024
置信度 0.74
-
Gene syntax—the order and arrangement of genes and their regulatory elements—shapes the dynamic coordination of both natural and synthetic gene circuits. Transcription at one locus profoundly impacts the transcription of nearby adjacent genes, but the molecula…
preprints
2025
置信度 0.74
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How best to explain the properties and capabilities of embodied minds? The conventional paradigm holds that living beings are to be understood as the sculpted products of genetics and environment, which determine form and function of the brain as the unique se…
preprints
2025
置信度 0.74
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Cell-free expression systems (CFES) are increasingly used alongside conventional biotechnological approaches to accelerate early-stage prototyping and are particularly valuable in point-of-use settings. However, their broader adoption remains limited by time- …
preprints
2026
置信度 0.74
-
The increasing prevalence of multi-drug-resistant (MDR) bacterial pathogens presents a critical global health threat, highlighting the urgent need for innovative approaches to understanding bacterial patho-genesis and developing effective therapies. This revie…
preprints
2024
置信度 0.74
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The expression of genes and engineered circuits can deeply vary when inserted into different genomic loci. This unpredictable performance of expression, termed context sensitivity, complicates strain development. Although the causes and mechanisms of context s…
preprints
2024
置信度 0.74
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The sensory transcription factors carry out gene expression in response to external stimuli like light. Further, they can be used in synthetic biological circuits to manipulate gene expression and thus can alter behavioral responses effectively. In this study,…
preprints
2025
置信度 0.74
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ABSTRACT Synthetic biology enables the precise control of bacterial population dynamics through engineered genetic circuits, paving the way for innovative therapeutic and biosensing applications. Here, we present genetic circuit design that leverages AHL (acyl…
preprints
2025
置信度 0.74
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Terminators are specific nucleotide sequences located at the 3’ end of a gene and contain transcription termination information. As a fundamental genetic regulatory element, terminators play a crucial role in the design of gene circuits. Accurately characteriz…
preprints
2025
置信度 0.74
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Vocal repertoires consist of a limited number of call types, even though their sounds can vary continuously in form. Where in the brain receivers partition this variation into discrete types is contested: different accounts place the emergence of categories in…
preprints
2026
置信度 0.74
-
Abstract Bacterial second messenger networks transmit environmental information through both amplitude and frequency modulation strategies. However, the mechanisms by which cells decode frequency-encoded signals remain poorly understood. By reconstructing the …
preprints
2025
置信度 0.74
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The honeybee gut microbiota plays a key role in shaping host health and susceptibility to disease. Yet, the nutrient environment it experiences within the gut remains poorly characterized. In particular, little is known about the spatial distribution of nutrie…
preprints
2025
置信度 0.74
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Post-transcriptional control systems offer new avenues to design synthetic circuits that offer reduced burden and less synthetic regulatory components compared to transcriptionally based tools. Herein, we repurpose a newly identified post-transcriptional inter…
preprints
2024
置信度 0.74
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Genetic circuits with only a few components can generate complex gene regulatory dynamics. Here, we combine stochastic modelling and single-cell time-lapse microscopy to reveal the possible dynamics generated by a key gene circuit motif: the mixed positive/neg…
preprints
2025
置信度 0.74
-
It is often desired, in the analysis or the design of biomolecular circuits, to search for parameters that satisfy certain specifications, such as on the number of the steady states or on their magnitudes. These problems are challenging because of the presence…
preprints
2024
置信度 0.74
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Classification of high-dimensional information is a ubiquitous computing paradigm across diverse biological systems, including organs such as the brain, down to signaling between individual cells. Inspired by the success of artificial neural networks in machin…
preprints
2025
置信度 0.74
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SUMMARY Cells have the capacity to encode and decode information in the temporal features of molecular signals. Many pathways, for example, generate either sustained or pulsatile responses depending on the context, and such diverse temporal behaviors have a pr…
preprints
2025
置信度 0.74
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ABSTRACT R6K plasmids are commonly used for a wide range of genome engineering applications due to their ability to support transient delivery of genetic cargoes in many hosts. The maintenance of R6K plasmids requires specific strains. Unfortunately, many of t…
preprints
2025
置信度 0.74
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The growing scale of genomic data poses significant challenges in terms of storage, compression, and real-time analysis. Traditional digital systems struggle to meet the demands of ultra-efficient, low-energy biological data processing. In this paper, we intro…
preprints
2025
置信度 0.74
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Engineering cell fate is fundamental for optimizing stem cell-based therapies aimed at replacing cells in patients suffering from trauma or disease. By timely administering molecular regulators - such as transcription factors, RNAs, or small molecules - in a p…
preprints
2024
置信度 0.74
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ABSTRACT Recombinases, which are enzymes that catalyze targeted DNA modifications, hold significant potential in synthetic biology. Their capacity to precisely manipulate genetic material enables the construction of complex genetic circuits that can be dynamic…
preprints
2024
置信度 0.74
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Plasmids are an essential tool for basic research and biotechnology applications. To optimize plasmid-based circuits, it is crucial to control plasmid integrity, including the formation of plasmid multimers. Multimers are tandem repeats of entire plasmids form…
preprints
2024
置信度 0.74
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Summary Associative conditioning is a fundamental learning paradigm that links salient stimuli to appropriate behavior. The vinegar fly is an important memory model that can associate odors with rewarding or punishing reinforcement stimuli via distinct sets of…
preprints
2025
置信度 0.74
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Abstract The yeast Saccharomyces cerevisiae is widely employed in industrial biotechnology for chemical and pharmaceutical production. However, engineering yeast for high product titers remains challenging due to metabolic imbalances and competition for cellul…
preprints
2025
置信度 0.74
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In cybergentics, internal control uses synthetic genetic circuits to bypass the sensing and actuation limits of external control. Currently, embedded controllers are limited to basic controllers, like PID. Here, we introduce the Embedded Extremum Seeking Contr…
preprints
2024
置信度 0.74
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Rhizobacteria play a central role in supporting plant growth, contributing to nutrient acquisition, stress tolerance and disease suppression. Harnessing and improving rhizosphere microbial communities therefore represents a promising avenue towards more sustai…
europepmc
2026
置信度 0.80
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KRAS is a prevalent oncogenic driver whose therapeutic targeting has remained challenging beyond the G12C mutation. Here, we developed a gene circuit platform that enables the in vivo self-assembly of small extracellular vesicles (sEVs) encapsulating KRAS-spec…
europepmc
2026
置信度 0.80
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Spatiotemporal control over cell fate and behavior within bioprinted constructs remains a key challenge in tissue engineering. Optogenetics offers versatile potential for non-invasive regulation of biological processes. Yet, its integration within large-scale,…
europepmc
2026
置信度 0.80
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Inducible gene expression systems are widely used in synthetic biology and gene therapy, yet their performance depends not only on regulator chemistry but also on circuit architecture. Here, we examine how promoter organization shapes TetR-based gene regulatio…
europepmc
2026
置信度 0.80
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Selective therapeutic gene activation in tumors remains challenging because tumor-enriched promoters often exhibit basal activity in non-target cells and may not fully capture intratumoral heterogeneity. In addition, direct promoter-driven expression of cytoto…
europepmc
2026
置信度 0.80
-
Immunotherapy has redefined oncology, yet its efficacy remains constrained by low response rates, primary or acquired resistance, immune-related toxicities, and escalating costs. Bacteria-mediated cancer immunotherapy (BCIT), which exploits the intratumoral mi…
europepmc
2026
置信度 0.80
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Predicting and controlling the behavior of individual cells across generations is a central challenge in systems and synthetic biology. Achieving this goal requires a thorough understanding of cellular behaviors, (mechanisms of) trait inheritance, and the impa…
datacite
Bijman, Eline Y.
2025
置信度 0.66
Synthetic biologyDirected EvolutionMATHEMATICAL MODELING AND SIMULATION IN BIOLOGYBifurcating autoregressive modelsMicroscopy
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Genetic circuits with only a few components can generate complex gene regulatory dynamics. Here, we combine stochastic modelling and single-cell time-lapse microscopy to map how a common circuit motif, the mixed positive/negative feedback loop, gives rise to d…
datacite
Locke, James
2026
置信度 0.66
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BACKGROUND & AIMS The liver performs a panoply of complex activities coordinating metabolic, immunologic and detoxification processes. Despite the liver's robustness and unique self-regeneration capacity, viral infection, autoimmune disorders, fatty liver …
datacite
Bai, Peng, Ye, Haifeng, Xie, Mingqi, Saxena, Pratik 等
2016
置信度 0.66
Gene- and cell-based therapyGenetically engineered cellsLiver diseaseRegenerationSynthetic biology
-
Beyond Body Weight A State-Resolved Multi-Organ Causal Framework for Obesity Treatment, Weight-Loss Plateaus, and Mechanism-Matched Sequential Therapy Hypothesis, human evidence synthesis, and translational experimental framework Abstract Background. Modern in…
datacite
Bouchelit, Mohammed El Amin
2026
置信度 0.66
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The Revised Real-World Spec Sheet now both missile work Feature Fictional Version Real-World Engineering Solution Power Source 12 V / 10 Ah Battery Engine-Driven High-Output Alternator Stealth Ionized Plasma Shroud DRFM Electronic Jamming + Radar Absorbent Ski…
datacite
lee, francis
2026
置信度 0.66
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This Perspective examines how induced pluripotent stem cell (iPSC)-derived immune-cell therapies may evolve beyond conventional CAR engineering toward programmable control of the entire therapeutic cell life cycle. It discusses the use of clonally defined iPSC…
datacite
Xia, Zhenbiao (Tim)
2026
置信度 0.66
Induced Pluripotent Stem CellsiPSCCAR-TCAR-NKCAR-NKT
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The field of synthetic biology combines principles from biology, engineering, and computer science to create novel biological systems with specific functions. It has made significant advances in engineering genetic circuits, creating biosensors and bioproducti…
datacite
Shobha Malaviya, Dibyaranjan Samal, Meesala Krishna Murthy, Pratima Khandayataray
2023
置信度 0.66
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Abstract The essential demarcation between living and non-living systems remains one of the central challenges in natural science. Traditional definitions rely on isolated lists of features such as metabolism, reproduction, and responsiveness, which fail to co…
datacite
Zhang, Xuchao
2026
置信度 0.66
definition of life; integrated information; edge of chaos; non-equilibrium thermodynamics; constraint satisfaction; synthetic biology
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Closed-loop gene circuits are paving the way toward self-driving medicine: therapeutics that continuously sense physiological signals, compute responses, and autonomously tune therapeutic output. Yet clinical practice still relies largely on open-loop dosing a…
datacite
Unal, Gokberk, Fussenegger, Martin
2026
置信度 0.66
Synthetic biologyGene circuitsFeedback controlCell and gene therapy
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MH370 Related Research Papers: MH370: Mathematical Proof of the Survival of All Passengers Within a Tensorial Capsule at Broken Ridge and a Depth of 4,648.35 Meters in the Southern Indian Ocean, at Coordinates Longitude 93.6165° E and Latitude 34.4812° S (3428…
datacite
JALALI, SEYED RASOUL
2026
置信度 0.66
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An operational-layer decomposition for cross-chassis genetic circuit design. Version 2 narrows the claims of v1 and corrects its cross-domain framing. The paper proposes seven candidate biological computation primitives (B1–B7) as a small operation set for eng…
datacite
Bieg, Michael
2026
置信度 0.66
biological primesgenetic circuitssynthetic biologychassis-agnostic compilationabstraction hierarchy
-
• Developed quantum codes based on Grover's algorithm using an IBM 127-qubit quantum simulator for large-scale genetic sequence analysis and optimization. • Successfully searched a 3,022-nucleotide database for a 50-nucleotide target sequence at exponential sp…
datacite
inquantio
2026
置信度 0.66
quantum biology
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• Development of the quantum algorithm 'QuBio.py' for searching and analyzing genetic information. • Successful detection of a 50-nucleotide target sequence within a 3,022-nucleotide database using a 127-qubit simulator on the IBM quantum platform. • Securing …
datacite
inquantio
2026
置信度 0.66
quantum biology
-
A study published on bioRxiv demonstrates the first hybrid quantum computing framework combining classical Hamming distance filtering with the Grover quantum search algorithm to overcome bottlenecks in massive genomic data analysis. Utilizing the IBM Qiskit 27…
datacite
inquantio
2026
置信度 0.66
quantum biology
-
Synthetic biology is an application field attempting to apply a rational engineering approach to the re-design of biological systems, to produce valuable and novel biological functions. To date the field has largely focused on the engineering of living systems…
datacite
Chappell, James Edward
2013
置信度 0.66
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Since the earliest human societies, microorganisms have been harnessed for their probiotic properties. In the 20th century, advances in DNA technology enabled the artificial enhancement of microbial traits, leading to the development of organisms with improved…
datacite
Maneira, Carla
2026
置信度 0.66
Synthetische BiologieGentechnologie570
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Synthetic biology applications call for efficient methods to generate large gene cassettes that encode complex gene circuits in order to avoid simultaneous delivery of multiple plasmids encoding individual genes. Multiple methods have been proposed to achieve …
datacite
Schmid-Burgk, Jonathan L., Xie, Zhen, Frank, Stefan, Winter, Sebastian Virreira 等
2012
置信度 0.66
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With the advent of high-throughput and genome-wide screening initiatives, there is a need for improved methods for cell-based assays. Current approaches require expensive equipment, rely on large-scale culturing formats not suited for small or rare sample type…
datacite
Woodruff, Kristina Pan
2017
置信度 0.66
microfluidicsmicroarrayslive cell printinghigh-throughput screeninghigh-content imaging
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Title: Topological Invariance of Signaling Obstructions in the INSR-PI3K-Akt Pathway: A Quantum Circuit Simulation Description: This research investigates the insulin signaling pathway (INSR-PI3K-Akt) by applying Sheaf Theory within a quantum circuit simulatio…
datacite
Usai, Luigi
2026
置信度 0.66
Teoria dei FasciSheaf TheoryCircuiti QuantisticiQuantum CircuitsPathway dell'Insulina
-
================================================================================ ZENODO METADATA UPDATE: UPDATED DESCRIPTIONS (ENGLISH & ITALIANO) Project: Topological Invariance of Cohomological Obstructions in the Wnt/beta-Catenin Complex Author: Luigi Usai …
datacite
Usai, Luigi
2026
置信度 0.66
Teoria dei FasciLuigi UsaiUsai LuigiSheaf TheoryCircuiti Quantistici
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Proteins are the fundamental molecular machines of life, orchestrating virtually every essential biological process. A proteinâ s structural architecture is encoded by its primary amino acid sequence, which in turn determines its biological activity. While com…
datacite
Elia, Maddalena
2026
置信度 0.66
computational protein designde novo designprotein engineeringdeep learningmetamorphic proteins
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Microbial communities exist in many facets of life, such as in the human body, including the microbiomes of the gut, mouth, respiratory tract, as well as that in the environment, including microbiomes of the soil, permafrost, and the ocean. While vastly differ…
datacite
Chu, Monica
2026
置信度 0.66
BioengineeringBioelectronicsElectrogeneticsIntercellular signalingMicrobial consortia
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Redox reactions provide a unique vantage point to bridge the disparate communication modalities of biological signal transduction and electronics. Electronic communication is rapid, well-studied, and easily user-operated, while also enabling integration with b…
datacite
Zakaria, Fauziah Rahma
2026
置信度 0.66
BioengineeringBiomedical engineeringMicrobiologybacteriaelectrogenetics
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Episode summary: Is depression a cognitive pattern you can think your way out of, or a biological condition that needs medication? The answer is both — and neither. This episode explores the history of reactive vs. endogenous depression, the DSM specifiers lik…
datacite
Rosehill, Daniel, Gemini 3.1 (Flash), Chatterbox TTS
2026
置信度 0.66
podcastai-generatedmy weird promptsneurosciencepsychopharmacology
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Graphs provide a natural language for relational data in chemistry, biology and optimisation. Graph neural networks (GNNs) have driven much of the recent progress in learning from such data through message passing, a single primitive that generalises convoluti…
datacite
Raj, Snehal, Coyle, Brian, Monbroussou, Léo, Ferreira-Martins, André J. 等
2026
置信度 0.66
Quantum Physics (quant-ph)Machine Learning (cs.LG)FOS: Physical sciencesFOS: Computer and information sciences
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Synthetic biology research and its industrial applications rely on deterministic spatiotemporal control of gene expression. Recently, electrochemical control of gene expression has been demonstrated in electrogenetic systems (redox-responsive promoters used al…
datacite
Lawrence, Joshua M, Yin, Yutong, Bombelli, Paolo, Scarampi, Alberto 等
2022
置信度 0.66
3101 Biochemistry and Cell Biology31 Biological SciencesGeneticsFOS: Biological sciencesBiotechnology
-
---mainfont: "FreeSerif"monofont: "FreeMono"mathfont: "FreeSerif"header-includes: - \usepackage{amsmath} - \usepackage{amssymb} - \usepackage{unicode-math}--- # Intro. ## Physical narrative, as a cognitive scaffold, is pedagogical, not ontological. This work d…
datacite
Gris Iscomeback
2026
置信度 0.66
grokkingdeeplearning
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Discrete dynamical models underpin systems biology, but we still lack substrate-agnostic diagnostics for identifying finite-horizon dynamical signatures that may be relevant to open-ended evolution (OEE), such as the recurrent production of novel phenotypic st…
datacite
López-Díaz, Amahury J., Torres, Pedro Juan Rivera, Febres, Gerardo L., Gershenson, Carlos
2025
置信度 0.66
Populations and Evolution (q-bio.PE)FOS: Biological sciencesFOS: Biological sciences
-
Modeling growth in bacterial cells is a major issue in systems and synthetic biology. Despite several growth rate functions proposed in the literature, most focus on nutrient composition without explicitly accounting for the possible perturbation provided by t…
datacite
Cimolato, Chiara, Gaetan, Elisa, Pasotti, Lorenzo, Schenato, Luca 等
2026
置信度 0.66
Quantitative Methods (q-bio.QM)FOS: Biological sciencesFOS: Biological sciences
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ابر-لاگرانژی ژنوم انسان (Human Genomic Super-Lagrangian - $\mathcal{L}_{Genom}^{(1155)}$) به عنوان "نرمافزار پایه" (Firmware) سیستم بیولوژیک، دقیقاً بیانگرِ تبدیل اطلاعات کیهانی (از بعد ۱۱۵۵) به ساختارهای مادی پروتئینی است. در این چارچوب، کروموزومها "هارد د…
datacite
HAMZAH, SEYED RASOUL
2026
置信度 0.66