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Protein-protein interactions (PPIs) are crucial for many diverse cellular processes, and dysregulated PPIs are often implicated in disease states. Therefore, monitoring PPIs is critical to understanding underlying biological processes and disease. Many differe…
datacite
Zinkus-Boltz, Julia Rose
2020
置信度 0.66
BiochemistryBioengineeringBiologyBiosensorDeep Mutational Scanning
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Sophisticated gene circuits built by synthetic biology can enable bacteria to sense their environment and respond predictably. Engineered biosensing bacteria outfitted with such circuits can potentially probe the human gut microbiome to prevent, diagnose, or t…
datacite
Hayashi, Naoki, Lai, Yong, Fuerte-Stone, Jay, Mimee, Mark 等
2024
置信度 0.66
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Stochastic Reaction Networks (SRNs) serve as a fundamental modeling paradigm for stochastic, discrete-state biological systems, ranging from biomolecular processes and synthetic genetic circuits to epidemic propagation and ecological dynamics. These models for…
datacite
Badolle, Quentin
2026
置信度 0.66
stochastic processesgradient estimationdeep learning
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Motivation: In principle, novel genetic circuits can be engineered using standard parts with well-understood functionalities. However, no model based on the simple composition of these parts has become a standard, mainly because it is difficult to define signa…
datacite
Marchisio, M. A., Stelling, J.
2008
置信度 0.66
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To achieve the comprehensive realisation of the computational platform and to establish the definitive closure of the mathematical boundary of the $P = NP$ problem, we dissect the formulation of the Hamzeh Comprehensive and Deterministic Hyper-Lagrangian ($\ma…
datacite
HAMZAH, SEYED RASOUL
2026
置信度 0.66
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This project contains defensive publications (prior art) disclosed in April 2026. The documents include: · APROS-V9.5: On-demand epigenetic reset system with 18 biomarkers, dynamic threshold function, 120 phase permutations. · SYBEL-KRONOS V2.0: Synthetic biol…
datacite
enes yünlü, Muzaffer
2026
置信度 0.66
Medicine and Health SciencesLife Sciences
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Despite decades of therapeutic advances, cardiovascular diseases remain the leading cause of global mortality, underscoring the need for strategies that move beyond untargeted systemic pharmacotherapy. Synthetic biology introduces a programmable therapeutic pa…
datacite
Khalilitousi, Mohammadali, Dhingra, Arshaan, Rohani, Leili, Weiss, Ron
2026
置信度 0.66
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This paper proposes a control theoretic framework to model and analyze the self-organized pattern formation of molecular concentrations in biomolecular communication networks, emerging applications in synthetic biology. In biomolecular communication networks, …
datacite
Hori, Yutaka, Miyazako, Hiroki, Kumagai, Soichiro, Hara, Shinji
2015
置信度 0.66
Molecular Networks (q-bio.MN)Systems and Control (eess.SY)Pattern Formation and Solitons (nlin.PS)FOS: Biological sciencesFOS: Biological sciences
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Homeostasis is a running theme in biology. Often achieved through feedback regulation strategies, homeostasis allows living cells to control their internal environment as a means for surviving changing and unfavourable environments. While many endogenous homeo…
datacite
Briat, Corentin, Gupta, Ankit, Khammash, Mustafa
2014
置信度 0.66
Optimization and Control (math.OC)Systems and Control (eess.SY)Probability (math.PR)Molecular Networks (q-bio.MN)FOS: Mathematics
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I am looking to have this framework reviewed, feel free to contact me at adrianneillpivetta@hotmail.compython codes for everything in the framework are at the end of the document This framework is structured as an interconnected three-volume trilogy that attem…
datacite
Pivetta, Adrian Neill
2026
置信度 0.66
PhysicsPhysics/methodsPhysics/standardsNuclear physicsMathematical physics
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I am looking to have this framework reviewed, feel free to contact me at adrianneillpivetta@hotmail.compython codes for everything in the framework are at the end of the document This framework is structured as an interconnected three-volume trilogy that attem…
datacite
Pivetta, Adrian Neill, Gemini
2026
置信度 0.66
PhysicsMathematical physicsPhysics/instrumentationPhysics/methodsNuclear physics
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Plants rely on precise communication between organelles and the nucleus to regulate gene expression-based stress responses, enabling acclimation to changing environments that impact photosynthesis and respiration. A major pathway in this communication is retro…
datacite
Tsang, Natalie
2026
置信度 0.66
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Synthetic cells, which are cell-sized systems constructed entirely from defined, non-living components, offer a powerful platform for studying biological processes and developing functional biomimetic constructs. Unlike engineered living cells, which are const…
datacite
Hwang, Sung-Won
2025
置信度 0.66
Synthetic cellSynthetic biologyStimuli-responsive materialChemical EngineeringFOS: Chemical engineering
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An increasing number of synthetic RNA-based tools with diverse functions and wide dynamic operating ranges have been characterised in recent years. These RNAs not only regulate gene expression but also serve as key components in biosensor design. Their use has…
datacite
Kuzembayeva, Alina
2026
置信度 0.66
570
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To characterize the behavior and robustness of cellular circuits is a major challenge for Systems Biology. Many of the published methods that address this question quantify the local robustness of the models. In this thesis, I tried to underpin the inappropria…
datacite
Hafner, Marc
2010
置信度 0.66
robustnesssystems biologysampling methodsbiological oscillatorsfeedback loops
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3rd International Conference on Life Sciences (LiSci 2026)July 28 ~ 29, 2026, Virtual Conferencehttps://lisci2026.org/Scope3rd International Conference on Life Sciences (LiSci 2026) brings together a global community of researchers, innovators, educators, and …
datacite
NA
2026
置信度 0.66
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In the field of synthetic biology, one of the aims of researchers is to control the flow of information in cells using genetic logic circuits. Similarly to digital electronic circuits, signals are divided into Boolean 0 and 1 values through the application of …
datacite
Schwarz, Tobias
2024
置信度 0.66
Genetic Design AutomationTechnology MappingGenetic CircuitsBranch-and-BoundSimulated Annealing
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RNA molecules lie at the heart of living organisms where they are associated with most of the cellular processes. They have recently emerged as one of the most promising elements for developing programmable genetic regulatory systems. RNA regulators have been …
datacite
Lehr, François-Xavier
2021
置信度 0.66
570
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Modern approaches in the field of biology, especially the field of synthetic biology, are based on design-build-test-learn (DBTL)-cycles to, e.g., generate optimized genetic constructs for various applications. The overall speed of one cycle mainly depends on …
datacite
Schlichting, Niels Carsten
2021
置信度 0.66
570
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Die Synthetische Biologie versteht sich als ein interdisziplinäres Forschungsgebiet, das die Entwicklung komplexer künstlicher biologischer Systeme zum Ziel hat. Neben der erfolgreichen Integration von synthetischen Schaltungen in lebende Organismen, bedarf es…
datacite
Falk, Johannes
2019
置信度 0.66
530
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openalex
Tae Seok Moon, Chunbo Lou, Alvin Tamsir, Brynne C. Stanton 等
2012-10-07
置信度 0.72
Synthetic biologyElectronic circuitComputer scienceLogic gateAND gate
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Since our ability to engineer biological systems is directly related to our ability to control gene expression, a central focus of synthetic biology has been to develop programmable genetic regulatory systems. Researchers are increasingly turning to RNA regula…
openalex
James Chappell, Kyle E. Watters, Melissa K. Takahashi, Julius B. Lucks
2015-06-18
置信度 0.72
Synthetic biologyComputational biologyRNABiologyFunction (biology)
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Abstract Optimizing growth conditions and culture media is a major goal in microbiology. A challenge is that nutrients can have complex, non-additive effects on growth. The fact that resources interact with one another has long been known in ecology, but syste…
preprints
2026
置信度 0.74
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Background The rapid increase in publicly available microbial and metagenomic data has created a growing demand for tools that can efficiently perform custom large-scale comparative searches and functional annotation. While BLAST+ remains the standard for sequ…
preprints
2025
置信度 0.74
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Multiple studies have highlighted the human microbiome’s potential as a biomarker for diagnosing diseases through its interaction with systems like the gut, immune, liver, and skin via key axes. Advances in sequencing technologies and highperformance computing…
preprints
2025
置信度 0.74
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Motivation Realising the value of large DNA sequence collections demands efficient search and extraction of sequences of interest. Search queries may vary in size from short gene sequences to multiple whole genomes that are too large to fit in computer memory.…
preprints
2025
置信度 0.74
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Three-dimensional electron microscopy (3D EM) enables the quantitative analysis of cellular ultrastructure. However, large-scale segmentation of whole-cell volumes poses a significant challenge, especially in biologically diverse systems. Unlike medical and an…
preprints
2026
置信度 0.74
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Volcanic soils provide a unique environment for studying microbial colonization and succession due to their extreme conditions and distinct geochemical profiles. This study focused on carbon monoxide (CO)-oxidizing microbial communities in volcanic soils of va…
preprints
2025
置信度 0.74
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C-type lectins (CTLs) play key roles in innate immunity and microbial carbohydrate recognition. In the disease vector mosquito Aedes aegypti , the CTLD-S family comprises 34 soluble CTLs whose members are implicated in flavivirus dissemination and microbial ho…
preprints
2026
置信度 0.74
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Background Diet is central to cardiovascular disease (CVD) prevention, yet free-living studies rarely capture what people eat at home or how closely they follow an assigned diet due to limitations in self-reporting. Short-term inpatient feeding studies, with a…
preprints
2026
置信度 0.74
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ABSTRACT The continuingly decreasing cost of next-generation sequencing has recently led to a significant increase in the number of microbiome-related studies, providing invaluable information for understanding host-microbiome interactions and their relation t…
preprints
2024
置信度 0.74
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ABSTRACT The human gastrointestinal tract (GIT) is central to human physiology, yet our understanding of the metabolite, microbial, and hormonal spatiotemporal dynamics in humans is limited. Here, we employ naso-enteral intubation to generate a spatiotemporall…
preprints
2025
置信度 0.74
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Background The clinical diagnosis of sepsis is based on non-specific criteria and blood culture remains the gold standard confirmatory test. While early results are of wide clinical benefit delayed reports lead to prolonged anti-microbial therapy which fosters…
preprints
2025
置信度 0.74
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Abstract Trade-offs among microbial traits determine community dynamics and affect carbon-cycling feedback to climate change. Using cross-continental temperature and aridity gradients, we determined soil prokaryotic phenotypic traits based on a novel marker ge…
preprints
2025
置信度 0.74
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Abstract Recurrent urinary tract infections (rUTIs) are a chronic, debilitating condition characterized by repeated infections and treatment failure with antibiotics. We present an attempt to decolonize the urinary and intestinal reservoirs between acute UTI e…
preprints
2025
置信度 0.74
-
Abstract Background Trichuris trichiura (whipworm) affects nearly 500 million people globally, causing chronic intestinal inflammation and contributing to malnutrition, growth stunting, and impaired cognitive development especially in children living in low-re…
preprints
2025
置信度 0.74
-
Rapid and comprehensive analysis of metagenomic data from samples associated with foodborne outbreaks is of critical importance in food safety. Equally important is the need for automated analysis pipelines that allow the rapid and effective construction of me…
preprints
2025
置信度 0.74
-
The human respiratory tract (RT) harbors complex microbial communities whose functions are critical to health and disease. Yet, current insights remain fragmented across anatomical sites, populations, and clinical states, limiting the field’s ability to define…
preprints
2025
置信度 0.74
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The use of 16S rRNA metabarcoding for functional prediction is limited by several biases. Shallow shotgun sequencing is a cost-effective and taxonomically high-resolution alternative to 16S rRNA metabarcoding, but the low sequencing depth limits functional inf…
preprints
2025
置信度 0.74
-
Abstract Background The avian gut virome plays a crucial role in shaping the gastrointestinal microbial ecosystem of birds. However, its taxonomic and functional diversity remains poorly characterized due to the absence of a dedicated reference database. This …
preprints
2025
置信度 0.74
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The gut microbiota plays an essential role in the conversion of anthocyanins and (epi-)catechins into smaller phenolic acids, which are then absorbed into the blood stream. The phenolic composition of a commercial bilberry extract and grape seed extract was as…
preprints
2026
置信度 0.74
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Abstract Advances in third-generation sequencing have enabled portable and real-time genomic sequencing, but real-time data processing remains a bottleneck, hampering on-site genomic analysis due to prohibitive time and energy costs. These technologies generat…
preprints
2025
置信度 0.74
-
Summary Accurate metagenomic taxonomic profiling is critical for understanding microbial communities. However, computational analysis often requires command-line proficiency and high-performance computing resources. To lower these barriers, we developed Metabu…
preprints
2025
置信度 0.74
-
Abstract Background: The gut microbiome (GM) is important for host health and survival, and is partially shaped by host immunogenetics. To date, no study has investigated the influence of host Major Histocompatibility Complex (MHC) genes on the metagenomically…
preprints
2025
置信度 0.74
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The generation of species trees from genomic data is an important step in understanding evolutionary relationships across the tree of life. With the increasing availability of genomic data, species tree inference methods which can easily and rapidly produce ac…
preprints
2026
置信度 0.74
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We asked whether infant microbiome composition, together with infants’ behavioral responses to early maternal unpredictability, can offer novel mechanistic insights into behavioral phenotypic variation in human development. Maternal unpredictability was comput…
preprints
2025
置信度 0.74
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Quorum sensing (QS) is a sophisticated bacterial cell-to-cell communication mechanism that allows bacteria to sense population density through the secretion and detection of diffusible small molecular signals. This process leads to the coordinated expression o…
preprints
2024
置信度 0.74
-
Abstract Infant gut microbiome assembly influences childhood growth and development. However, current understanding is based almost exclusively on infants from highly industrialised, high-income countries. Here, we present a high-resolution map of gut microbio…
preprints
2025
置信度 0.74
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In high-dimensional omics studies, researchers often conduct kernel association testing to power-fully detect the relationship of the genetic or microbial composition with human health or disease. Especially, in human microbiome studies, its dimension reductio…
preprints
2025
置信度 0.74
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ABSTRACT Associations between feather mosses and cyanobacteria are crucial sources of new biologically available nitrogen (N) in arctic and subarctic ecosystems. The physiology of both mosses and cyanobacteria is strongly influenced by environmental factors su…
preprints
2025
置信度 0.74
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Abstract Vaccines represent a major public health intervention against infectious diseases and potentially cancer. Surrogate markers of vaccine efficacy usually rely on neutralizing antibody titers afflicted by high interindividual variabilities. Automated mul…
preprints
2025
置信度 0.74
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Understanding island biodiversity requires studying the processes driving its assembly and examining how these processes vary over time, across lineages, and across different islands. The DAISIE (Dynamic Assembly of Island biota through Speciation, Immigration…
preprints
2025
置信度 0.74
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Environmental DNA sequencing has revolutionized our understanding of microbial diversity and ecology. Microbiomes have now been sequenced across the entire planet—from the deep subsurface to the mountain tops—covering a myriad of hosts, biomes, and conditions.…
preprints
2025
置信度 0.74
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The emergence of nanopore sequencing technology has the potential to transform metagenomics by offering low-cost, portable, and long-read sequencing capabilities. Furthermore, these platforms enable real-time data generation, which could significantly reduce t…
preprints
2025
置信度 0.74
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The emergence of eukaryotes from a merger between an archaeon and a bacterial cell ∼two billion years ago involved a profound change in cellular organisation. While the order in which different features of the eukaryotic cell arose remains a matter of controve…
preprints
2025
置信度 0.74
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Abstract Background: The gut microbiota critically influences poultry health, nutrition, feed efficiency (FE), and overall productivity. However, the relationship between gut microbes, including bacteria and bacteriophages, and FE in ducks remains underexplore…
preprints
2025
置信度 0.74
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Diatom-bacteria interactions drive biogeochemical fluxes at the base of the marine food-web. While the role of bacteria in recycling organic matter is well established, their potential to actively induce algal death remains poorly understood. Here we examined …
preprints
2025
置信度 0.74
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There is growing evidence that microbes can facilitate plant growth in metal-rich soils. However, our current understanding of how plants recruit their microbiomes under abiotic stress remains incomplete. Serpentine soils are elementally skewed, with high conc…
preprints
2025
置信度 0.74
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Consider comparing a sequencing read of unknown origin to a set of reference genomes. This problem underlines many applications, including metagenomic analyses. The exact genome generating the read is not in the reference set, but may be evolutionarily related…
preprints
2025
置信度 0.74
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Abstract Zoosporic fungi of the Chytridiomycota phylum are lethal parasites of algae in Arctic freshwater and marine environments, and their presence has been confirmed as dominant fungi in various habitats on the Greenland Ice Sheet by amplicon sequencing. Gl…
preprints
2025
置信度 0.74
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ABSTRACT Background Synthetic microbial communities offer an opportunity to conduct reductionist research in tractable model systems. However, deriving abundances of highly related strains within these communities is currently unreliable. 16S rRNA gene sequenc…
preprints
2024
置信度 0.74
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Background The human gastrointestinal microbiota plays a crucial role in immune modulation, metabolism, and pathogen resistance. Soil-transmitted helminth (STH) infections, including Trichuris trichiura (whipworm), significantly alter gut microbial composition…
preprints
2025
置信度 0.74
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Microbiome composition and function are strongly influenced by environmental factors, with major shifts driven by intensified anthropogenic pressures over the past centuries. This timeframe extends beyond the scope of traditional experimental or longitudinal s…
preprints
2025
置信度 0.74
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Many microbial communities form multispecies biofilms where cells interact through diffusible molecules. In these biofilms, multiple interactions, often with opposing effects, occur simultaneously, yet we lack quantitative frameworks to predict how they combin…
preprints
2026
置信度 0.74
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Microbial genome-wide association study (GWAS) tools often require manual data processing steps, lack comprehensive workflows, and are limited by scalability issues, thus hindering the exploration of bacterial genetic traits. To address these challenges, we de…
preprints
2025
置信度 0.74
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Abstract Objectives Vascular graft/endograft infections (VGEI) are difficult-to-treat and associated with high morbidity and mortality. Up to 40% of VGEI are polymicrobial, complicating clinical management. This study investigates microbial interactions and th…
preprints
2025
置信度 0.74
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Sequencing has transformed microbial studies, enabling metagenomic analysis of microbial communities without the need for culturing or prior knowledge of sample composition. The essential analysis of the primary sequencing reads, however, is complex and led to…
preprints
2025
置信度 0.74
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ABSTRACT In phylogenomics, gene tree reconstruction depends on multiple sequence alignment (MSA) and tree inference, and ongoing work continues to improve inference quality. Denser taxon sampling has been associated with improved gene tree inference, suggestin…
preprints
2026
置信度 0.74
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Plant-associated microbiomes comprise diverse microbial species that coexist and interact, influencing community structure and host plant health. However, our understanding of these interactions in field conditions and at strain-resolution remains limited. Thi…
preprints
2025
置信度 0.74
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Engineering multicellular consortia, where information processing is distributed across specialized cell types, offers a promising strategy for implementing sophisticated biocomputing systems. However, a major challenge remains in establishing orthogonal inter…
europepmc
2024
置信度 0.80
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Bacterial cooperation involves the exchange of metabolites, which can range from costless byproducts of metabolism to intentionally produced and costly molecules. These interactions occur across spatial scales, from direct cell contact to the diffusion of meta…
preprints
2025
置信度 0.74
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Specialized host-microbe interfaces are central to cellular interactions in plants. Intracellular structures such as haustoria formed by filamentous pathogens mediate nutrient exchange and effector delivery to host cells. Despite their biological importance, t…
preprints
2026
置信度 0.74
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Abstract Helminth-driven immunomodulation contributes to immune heterogeneity in tropical environments. Whether it can be reversed by BCG revaccination, an inducer of trained immunity, remains unknown. We applied high-dimensional mass cytometry to profile immu…
preprints
2026
置信度 0.74
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Plasmid transfer among bacteria is an evolutionary driver of the spread of antibiotic resistance. Surface-associated bacterial biomass is a hotspot for plasmid transfer due to the dense spatial packing of cells. Compared to plasmid dynamics within a single bio…
preprints
2026
置信度 0.74
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Background To study communities of micro-organisms taxonomically and functionally, metagenomic analyses are now often used. If there is no reference gene catalogue, a de novo approach is required. Because genomes are easier to interpret than contigs, the recov…
preprints
2024
置信度 0.74
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The mycobiome is now recognized as a critical part of the human microbial ecosystem, playing a significant role in both health and disease. Mycobiome research is currently in its infancy and relies on fungal-specific primers with challenges in bioinformatics t…
preprints
2025
置信度 0.74
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ABSTRACT The human microbiome is increasingly recognized for its crucial role in the development and progression of neurodegenerative diseases. While the gut-brain axis has been extensively studied, the contribution of the oral microbiome and gut-oral tropism …
preprints
2024
置信度 0.74
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ABSTRACT Bacteriophages play a crucial role in shaping microbial community dynamics in marine systems and have the potential to stimulate surges in pathogenic bacteria facilitating disease outbreaks. Notwithstanding, bacteriophages also serve as valuable bioco…
preprints
2024
置信度 0.74
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Protein structural context strongly influences the functional outcomes of mutations, but exploiting this intuition to interpret the consequences of natural variants has been limited by the paucity of structural information. Here, we show that simple molecular …
preprints
2025
置信度 0.74
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Abstract The increasing prevalence of inflammatory bowel disease (IBD) and rising pollution from micro-and nanoplastic (MNP) particles has prompted investigations on their potential interconnection. To elucidate the complex relationship between IBD and exposur…
preprints
2025
置信度 0.74
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ABSTRACT Phages are typically viewed as very rapidly evolving biological entities. Little is known, however, about whether and how phages can establish long-term genetic stability. We addressed this eco-evolutionary question in an open marine animal associated…
preprints
2025
置信度 0.74
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ABSTRACT Plant cell wall (CW) integrity signaling enables early detection of microbial invasion, yet the receptors involved and their spatial and temporal dynamics during infection remain largely unknown. We identify ATHENA (ATHE)/MEE39, a previously uncharact…
preprints
2026
置信度 0.74
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Microbial metabolic gene clusters encode the biosynthesis or catabolism of metabolites that facilitate ecological specialization, mediate microbiome interactions and constitute a major source of medicines and crop protection agents. Here, we present BiG-SCAPE …
preprints
2025
置信度 0.74
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ABSTRACT Prokaryotic genomes harbor a variety of functional elements encoded as contiguous multi-gene clusters, with biosynthetic gene clusters (BGCs, genetic determinants of secondary metabolite biosynthesis) serving as a notable example. In a typical workflo…
preprints
2025
置信度 0.74
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ABSTRACT Understanding how bacterial diversity at strain level resolution shapes host physiology is a central challenge in microbiome research. The vast, functionally unknown genetic diversity within a species pangenome makes it difficult to connect genes to f…
preprints
2026
置信度 0.74
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ABSTRACT Structural prediction by artificial intelligence (AI) can be powerful new instruments to discover novel protein-protein interactions, but the community still grapples with the implementation, opportunities and limitations. Here, we discuss and re-anal…
preprints
2024
置信度 0.74
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While rapid progress has been made to characterize the bacterial and archaeal populations of the rumen microbiome, insight into how they interact with keystone protozoal species remains elusive. Here, we reveal two distinct rumen community types (RCT-A and RCT…
preprints
2024
置信度 0.74
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1 Comprehensive, sex-specific whole-body models (WBMs) accounting for organ-specific metabolism have been developed to allow for the simulation of adult and infant metabolism. These WBMs are evaluated daily, giving insights into metabolic flux changes that occ…
preprints
2024
置信度 0.74
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We introduce BoltzGen , an all-atom generative model for designing proteins and peptides across all modalities to bind a wide range of biomolecular targets. BoltzGen builds strong structural reasoning capabilities about target-binder interactions into its gene…
preprints
2025
置信度 0.74
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Acinetobacter baumannii remains a pervasive nosocomial pathogen, with international clone 2 (IC2) being the most successful lineage. IC2 is often discussed as a singular entity, and the genomic factors behind its success over other lineages are poorly characte…
preprints
2026
置信度 0.74
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Background Current exposure-health models rely on averaged, residential-based environmental exposures, failing to account for human movement. This aggregation can lead to exposure misclassification and biased exposure–response estimates, potentially distorting…
preprints
2026
置信度 0.74
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Quantitative analysis of bacterial dynamics in time-lapse microscopy requires robust tracking pipelines, yet selecting and optimizing algorithms for specific experiments remains challenging. Indeed, Microbiologists are confronted with numerous algorithms that …
preprints
2026
置信度 0.74
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Butyrate, a short-chain fatty acid (SCFA) produced by microbial fermentation of dietary fiber, exerts beneficial metabolic and immunomodulatory functions through hyperactivation of the histone acetylase (HAT) p300 and inhibition of histone deacetylases (HDAC).…
preprints
2025
置信度 0.74
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ABSTRACT Advances in metagenome sequencing data continue to enable new methods for analyzing biological systems. When handling microbial profile data, metagenome sequencing has proven to be far more comprehensive than traditional methods such as 16s rRNA data,…
preprints
2023
置信度 0.74
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ABSTRACT Hanseniaspora species stand out among yeasts for having the smallest genomes, marked by extensive gene family contractions. Consequently, they have been proposed as model organisms for studying the evolution of free-living cells lacking genes otherwis…
preprints
2025
置信度 0.74
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The human whipworm parasite, Trichuris trichiura, poses a critical public health problem, affecting over 400 million people globally and responding poorly to the standard-of-care - benzimidazole chemotherapy. Recent efforts aimed at developing improved treatme…
preprints
2025
置信度 0.74
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Kombucha is a type of tea that is fermented using yeast and bacteria. During this process, a film made of cellulose is produced. This film has unique properties such as biodegradability, flexibility, shape conformability, and ability to self-grow, as well as b…
preprints
2024
置信度 0.74
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ABSTRACT Evolutionary studies in bacteria have emphasized genetic and metabolic diversity, while cell-size variation has received less attention. Here we introduce MEDUSSA, a high-throughput method for precise bacterial cell-size profiling based on automatic s…
preprints
2025
置信度 0.74
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Abstract Gram-negative bacteria are shielded by an asymmetric outer membrane whose biogenesis depends on the lipopolysaccharide transport (Lpt) machinery. Therein, the essential membrane protein LptD mediates the final lipopolysaccharide insertion step, making…
preprints
2025
置信度 0.74
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Detailed understanding of plasmid-host physiological interactions and recombinant protein expression is crucial for the design and optimization of plasmid DNA (pDNA) manufacturing processes. Successfully transformed host cells carrying one or more copies of a …
preprints
2025
置信度 0.74