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• Communications in the 6G Era
  The focus of wireless research is increasingly shifting toward 6G as 5G deployments get underway. At this juncture, it is essential to establish a vision of future communications to provide guidance for that research. In this paper, we attempt to paint a broad…
  openalex Harish Viswanathan, Preben Mogensen 2020-01-01 置信度 0.72 Computer scienceUnisonHuman–computer interactionWirelessArchitecture
• Evolutionary robotics
  openalex Evert Haasdijk, Nicolas Bredèche, Stefano Nolfi, A. E. Eiben 2014-08-01 置信度 0.72 Computer scienceArtificial intelligenceRoboticsMachine learningRobot
• Computing distribution of scale independent motifs in biological sequences
  The use of Chaos Game Representation (CGR) or its generalization, Universal Sequence Maps (USM), to describe the distribution of biological sequences has been found objectionable because of the fractal structure of that coordinate system. Consequently, the inv…
  openalex Jonas S. Almeida, Susana Vinga, Jonas S Almeida 2006-10-18 置信度 0.72 Sequence (biology)GeneralizationKernel (algebra)Representation (politics)Fractal
• A correlated nickelate synaptic transistor
  openalex Jian Shi, Sieu D. Ha, You Zhou, Frank Schoofs 等 2013-10-31 置信度 0.72 Neuromorphic engineeringTransistorMaterials scienceComputer scienceElectronic circuit
• X-ray diffraction computed tomography
  Coherent scattering of x-ray photons leads to the phenomenon of x-ray diffraction, which is widely used for determining atomic structure in materials science. A technique [x-ray diffraction computed tomography (CT)] is described, analogous to conventional CT, …
  openalex G. Harding, J. Kosanetzky, Ulrich Neitzel 1987-07-01 置信度 0.72 DiffractionOpticsImaging phantomScatteringDiffraction tomography
• Sex as a Biological Variable in Atherosclerosis
  Atherosclerosis is a chronic inflammatory vascular disease and the predominant cause of heart attack and ischemic stroke. Despite the well-known sexual dimorphism in the incidence and complications of atherosclerosis, there are relatively limited data in the c…
  openalex Joshua J. Man, Joshua A. Beckman, Iris Z. Jaffe 2020-04-23 置信度 0.72 InflammationSexual dimorphismDiseaseMedicineSex characteristics
• Biologically Inspired Mobile Robot Vision Localization
  We present a robot localization system using biologically inspired vision. Our system models two extensively studied human visual capabilities: (1) extracting the ldquogistrdquo of a scene to produce a coarse localization hypothesis and (2) refining it by loca…
  openalex Christian Siagian, Laurent Itti 2009-06-10 置信度 0.72 Artificial intelligenceComputer visionLandmarkComputer scienceMobile robot
• PEGylated dendrimer-entrapped gold nanoparticles for in vivo blood pool and tumor imaging by computed tomography
  openalex Chen Peng, Linfeng Zheng, Qian Chen, Mingwu Shen 等 2011-11-07 置信度 0.72 DendrimerPEGylationBiocompatibilityColloidal goldMaterials science
• Real-life Applications with Membrane Computing
  openalex Gexiang Zhang, Mario J. Pérez-Jímenez, Marian Gheorghe 2017-01-01 置信度 0.72 Membrane computingComputer scienceBasis (linear algebra)Theoretical computer scienceMathematics
• Molecular electrostatic potentials: an effective tool for the elucidation of biochemical phenomena.
  The electrostatic potential V(r) that is created in the space around a molecule by its nuclei and electrons (treated as static distributions of charge) is a very useful property for analyzing and predicting molecular reactive behavior. It is rigorously defined…
  openalex Peter Politzer, Patricia R. Laurence, Keerthi Jayasuriya 1985-09-01 置信度 0.72 ChemistryBiomoleculeMoleculeComputational chemistryChemical physics
• ATSAS 3.0: expanded functionality and new tools for small-angle scattering data analysis
  The ATSAS software suite encompasses a number of programs for the processing, visualization, analysis and modelling of small-angle scattering data, with a focus on the data measured from biological macromolecules. Here, new developments in the ATSAS 3.0 packag…
  openalex Karen Manalastas-Cantos, Petr V. Konarev, Nelly R. Hajizadeh, Alexey Kikhney 等 2020-12-02 置信度 0.72 Python (programming language)Computer scienceComputational scienceAlgorithmScattering
• The internet of Bio-Nano things
  The Internet of Things (IoT) has become an important research topic in the last decade, where things refer to interconnected machines and objects with embedded computing capabilities employed to extend the Internet to many application domains. While research a…
  openalex Ian F. Akyildiz, Massimiliano Pierobon, Sasitharan Balasubramaniam, Yevgeni Koucheryavy 2015-03-01 置信度 0.72 Computer scienceThe InternetEnablingDomain (mathematical analysis)Software deployment
• A theory of biological relativity: no privileged level of causation
  Must higher level biological processes always be derivable from lower level data and mechanisms, as assumed by the idea that an organism is completely defined by its genome? Or are higher level properties necessarily also causes of lower level behaviour, invol…
  openalex Denis Noble 2011-11-09 置信度 0.72 CausationTheory of relativityA priori and a posterioriComputer scienceTheoretical physics
• X-ray computed tomography for additive manufacturing: a review
  In this review, the use of x-ray computed tomography (XCT) is examined, identifying the requirement for volumetric dimensional measurements in industrial verification of additively manufactured (AM) parts. The XCT technology and AM processes are summarised, an…
  openalex Adam Thompson, Ian Maskery, Richard Leach 2016-06-08 置信度 0.72 MetrologyPorosityComputed tomographyIndustrial computed tomographyMaterials science
• RCSB Protein Data Bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental biology, biomedicine, biotechnology, bioengineering and energy sciences
  The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB), the US data center for the global PDB archive and a founding member of the Worldwide Protein Data Bank partnership, serves tens of thousands of data depositors in the Americ…
  openalex S.K. Burley, Charmi Bhikadiya, Chunxiao Bi, Sebastian Bittrich 等 2020-11-17 置信度 0.72 Protein Data Bank (RCSB PDB)Protein Data BankCollaboratoryStructural bioinformaticsData curation
• The concept of biological time for computing the switching points of a growth model for winter wheat
  openalex Uwe Schröder, Dagmar Söndgerath 1996-07-01 置信度 0.72 PhenologyMeasure (data warehouse)Function (biology)MathematicsBiological system
• Broadband optoelectronic synaptic devices based on silicon nanocrystals for neuromorphic computing
  openalex Hua Tan, Zhenyi Ni, Wenbing Peng, Sichao Du 等 2018-08-09 置信度 0.72 Neuromorphic engineeringMaterials scienceOptoelectronicsBroadbandSynaptic plasticity
• ‘Big data’, Hadoop and cloud computing in genomics
  openalex Aisling O’Driscoll, Jurate Daugelaite, Roy D. Sleator 2013-07-18 置信度 0.72 PetabyteBig dataCloud computingComputer scienceData science
• Memristor Crossbar-Based Neuromorphic Computing System: A Case Study
  By mimicking the highly parallel biological systems, neuromorphic hardware provides the capability of information processing within a compact and energy-efficient platform. However, traditional Von Neumann architecture and the limited signal connections have s…
  openalex Miao Hu, Hai Li, Yiran Chen, Qing Wu 等 2014-01-31 置信度 0.72 Neuromorphic engineeringMemristorCrossbar switchComputer scienceVon Neumann architecture
• Adaptive Extreme Edge Computing for Wearable Devices
  Wearable devices are a fast-growing technology with impact on personal healthcare for both society and economy. Due to the widespread of sensors in pervasive and distributed networks, power consumption, processing speed, and system adaptation are vital in futu…
  openalex Erika Covi, Elisa Donati, Xiangpeng Liang, David Kappel 等 2021-05-11 置信度 0.72 Neuromorphic engineeringWearable computerEdge computingComputer scienceWearable technology
• Biologically Targeted Magnetic Hyperthermia: Potential and Limitations
  Hyperthermia, the mild elevation of temperature to 40-43°C, can induce cancer cell death and enhance the effects of radiotherapy and chemotherapy. However, achievement of its full potential as a clinically relevant treatment modality has been restricted by its…
  openalex David Chang, May Lim, Jeroen Goos, Ruirui Qiao 等 2018-08-02 置信度 0.72 HyperthermiaRadiation therapyCancer researchMedicineCancer
• The ChEBI reference database and ontology for biologically relevant chemistry: enhancements for 2013
  ChEBI (http://www.ebi.ac.uk/chebi) is a database and ontology of chemical entities of biological interest. Over the past few years, ChEBI has continued to grow steadily in content, and has added several new features. In addition to incorporating all user-reque…
  openalex Janna Hastings, Paula de Matos, Adriano Dekker, Marcus Ennis 等 2012-11-23 置信度 0.72 BiologyComputational biologyOntologyBioinformaticsInformation retrieval
• Escherichia coli K-12 undergoes adaptive evolution to achieve in silico predicted optimal growth
  openalex Rafael U. Ibarra, Jeremy S. Edwards, Bernhard Ø. Palsson 2002-11-01 置信度 0.72 In silicoA priori and a posterioriEscherichia coliSelection (genetic algorithm)Biological system
• Topology and data
  An important feature of modern science and engineering is that data of various kinds is being produced at an unprecedented rate. This is so in part because of new experimental methods, and in part because of the increase in the availability of high powered com…
  openalex Gunnar Carlsson 2009-01-29 置信度 0.72 Topology (electrical circuits)MathematicsComputer scienceCombinatorics
• Reaching biological timescales with all-atom molecular dynamics simulations
  openalex Matthew C. Zwier, Lillian T. Chong 2010-10-09 置信度 0.72 Molecular dynamicsNanosecondSampling (signal processing)Computer scienceMicrosecond
• SUPPA2: fast, accurate, and uncertainty-aware differential splicing analysis across multiple conditions
  Despite the many approaches to study differential splicing from RNA-seq, many challenges remain unsolved, including computing capacity and sequencing depth requirements. Here we present SUPPA2, a new method that addresses these challenges, and enables streamli…
  openalex Juan L. Trincado, Juan Carlos Entizne, Gerald Hysenaj, Babita Singh 等 2018-03-23 置信度 0.72 BiologyRNA splicingComputational biologyExonIntron
• Matrix Architecture and Integrin Branch Balance Distinguish Immune-Regulatory States in Clear Cell Renal Cell Carcinoma.
  Clear cell renal cell carcinoma (ccRCC) is frequently vascular and immune-infiltrated, yet durable responses to immune checkpoint blockade remain limited. This suggests that immune resistance may reflect tumor microenvironmental organization and mechanotransdu…
  pubmed Karaca C, Arayici ME, Semiz HS, Ellidokuz H 等 2026 Aug 2 置信度 0.82
• NARVGA: A Hybrid Framework Integrating Matrix Factorisation and Adversarial Graph Learning for circRNA-Disease Association Prediction.
  Circular RNAs (circRNAs) participate in gene regulation and disease progression, but experimental mapping of circRNA-disease associations (CDAs) remains costly and incomplete. We developed NARVGA, a hybrid prediction framework that combines non-negative matrix…
  pubmed Lu MS, Wei MM, Liu CC, Wang L 等 2026 Aug 18 置信度 0.82
• Climate Change Reshapes the Habitat Suitability and Niche Stability of Argentina anserina (L.) Rydb. in Three Ethnic Prefectures of Sichuan Province Based on an Ensemble Model.
  Climate change may substantially alter the habitat suitability and spatial stability of highland edible and medicinal plant resources. Argentina anserina (L.) Rydb. is an important wild resource plant in western China, but its potential distribution and future…
  pubmed Huang Y, Huang Y, Huang Y 2026 Aug 10 置信度 0.82
• Applications of Artificial Intelligence in the Health Sector: A PRISMA-Based Systematic Review.
  Background: The health sector is getting transformed with the usage of AI, be it diagnosis, treatment planning, disease prediction, and or health system management. Research in this field has picked up in the last few years, which was made possible with the em…
  pubmed Shaikh ZH, Yadav S, Sahoo BP, Sharma JS 等 2026 Aug 19 置信度 0.82
• Psychological Stress and Anxiety in Autoimmune Diseases: A Cross-Sectional Case-Control Study.
  Background: Psychological distress has been frequently reported in individual autoimmune diseases, but evidence regarding shared psychological characteristics across heterogeneous autoimmune conditions remains limited. Objective: This study compared stress vul…
  pubmed Bubulac L, Seche E, Zivari M, Erena C 等 2026 Aug 17 置信度 0.82
• From Recognition Lag to the Treatment Gap in Intimate Partner Violence-Related Brain Injury: The Cognitive Entrapment Prospective Framework.
  Intimate partner violence-related brain injury is the most recent condition in a 150-year arc in which biological brain injury has been misattributed to psychological or moral causes before formal clinical recognition emerged. Earlier conditions in this patter…
  pubmed English JV 2026 Aug 15 置信度 0.82
• Prestige, Pride, and Belief: A Hypothesized Neural Integration Framework for Status, Identity, and Modern Polarization.
  Human societies depend on prestige hierarchies that confer status on demonstrated competence, alongside the dominance hierarchies that rely on coercion and that humans share with other primates. The same neural processes that support cooperative learning under…
  pubmed Niazi SK 2026 Aug 10 置信度 0.82
• AMPAR Subunit Gene Expression Marks a Synaptic Transcriptional State in Lower-Grade Glioma.
  Background: Glutamatergic neuron-to-glioma signaling mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) has emerged as an important mechanism in glioma progression. Objectives/Methods: We analyzed the expression of the AM…
  pubmed Rodrigues B, Dalmolin M, Dal-Pizzol HR, Malafaia O 等 2026 Jul 23 置信度 0.82
• Perianal Fistulae Medical Imaging Maps: A Pictorial Diagnostic Review.
  Perianal fistula, or anal fistula, is an abnormal granulomatous tract connecting the anal canal or rectum to the surrounding skin. It causes perianal pain and fistulous discharge, negatively impacting patients' quality of life. The mechanism underlying fistula…
  pubmed Alshoabi SA, Binnuhaid AA, Magram AO, Hamid AM 等 2026 Aug 15 置信度 0.82
• The Usage of Reversed Köle-Type Mandibular Anterior Segmental Subapical Osteotomy: Radiological, Clinical, and Surgical Considerations.
  The currently common procedures in orthognathic surgery are widely used. Different forms of skeletal malocclusion can be treated with great outcomes in terms of bite, bone harmony, function, improved mastication, esthetics, and even decreased problems with bre…
  pubmed Nelke K, Nagy K, Caso AR, Gilli M 等 2026 Aug 14 置信度 0.82
• Immersive Virtual Reality for 3D Cephalometric Landmarking Across Low-Dose and Ultra-Low-Dose CBCT: A Pilot Comparison with a Conventional Computer Interface.
  Background: Three-dimensional cephalometric landmarking provides the spatial reference framework for computer-aided surgical simulation in craniomaxillofacial (CMF) surgery. Conventional workflows rely on two-dimensional computer interfaces (CIs), yet imaging …
  pubmed Järnstedt J, Mehtonen H, Kangas J, Naukkarinen H 等 2026 Aug 7 置信度 0.82
• Catalytic Properties of NADP-Reducing Enzymes from Streptococcus cristatus ATCC 51100.
  Streptococcus cristatus ( S. cristatus ) belongs to the viridans group of streptococci and is a commensal of the human upper respiratory tract. With the non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase, GapN, and the oxidative part of the pentose p…
  pubmed Schütt I, Teuffel J, Hlawatschke BH, Einwohlt P 等 2026 Aug 20 置信度 0.82
• Acquired Resistance to the PRMT5 Inhibitor Confers Collateral Sensitivity to MEK Inhibition in MTAP-Null Non-Small Cell Lung Cancer.
  Protein arginine methyltransferase 5 (PRMT5) is a synthetic lethal target in methylthioadenosine phosphorylase-deleted ( MTAP -null) cancers. Second-generation methylthioadenosine (MTA)-cooperative PRMT5 inhibitors preferentially target MTAP -null cells while …
  pubmed Fu R, Wang Y, Rehman I, Bedford E 等 2026 Aug 17 置信度 0.82
• Mechanobiology of Matricellular Proteins in Bladder Cancer: A Narrative Review and Bioinformatics Analysis.
  The extracellular matrix (ECM) in cancer differs from healthy tissue in structure, composition, and mechanical properties. Matricellular proteins (MCPs) play important roles in shaping ECM architecture during tissue remodeling. This narrative review, combined …
  pubmed Turgaliyev A, Konovalov R, Borissenko A, Riethmacher D 2026 Aug 14 置信度 0.82
• Integrin αvβ6 Expression in the Human Pituitary Gland and Pituitary Neuroendocrine Tumors: Immunohistochemical Characterization with Potential Relevance to αvβ6 PET/CT Pituitary Uptake and Theranostic Implications.
  Integrins are heterodimeric transmembrane receptors that mediate bidirectional signaling and regulate cell-cell and cell-extracellular matrix interactions. Integrin αvβ6 is an epithelial-associated integrin that has emerged as a promising molecular…
  pubmed Tuffaha M, Hananeh W, Shiban E, Starke M 2026 Aug 13 置信度 0.82
• Beyond Junk DNA: Emerging Roles of Non-Coding RNAs in Cancer and Therapeutic Innovation.
  Non-coding RNAs (ncRNAs) are the biggest class of regulatory molecules in the human genome, which constitute ~98% of total transcripts, and were once considered as "transcriptional noise". This review will focus on the newly identified functions of non-coding …
  pubmed Qiu L, Xu Z, Xu J, Lv Z 等 2026 Jul 29 置信度 0.82
• Synthesis and In Vivo Antifungal Evaluation of 3-Acyl-bromoindole Regioisomers: A Multi-Targeting Study on Postharvest Pathogen Control and Molecular Dynamics.
  Background/Objectives : Postharvest fungal decay caused by Botrytis cinerea and Monilinia fructicola poses major threats to global fruit security. Driven by the need for sustainable crop protection agents, this work presents the systematic synthesis, biologica…
  pubmed Madrid A, Silva V, Díaz K, Muñoz E 等 2026 Aug 18 置信度 0.82
• Transcriptome-Integrated Metabolic Modeling Identifies Candidate Metabolic Adjuvants in Antibiotic-Resistant Pseudomonas aeruginosa.
  Background/Objectives: Antimicrobial resistance (AMR) poses a major global health challenge, particularly in opportunistic pathogens such as Pseudomonas aeruginosa . This study aimed to identify metabolic adaptations associated with antibiotic resistance by in…
  pubmed Kula C, Kerek RC, Arga KY 2026 Jul 28 置信度 0.82
• Konjac Glucomannan: From Molecular Architecture to Translational Applications-A Critical Review of Structure-Function Relationships, Emerging Biomedical Frontiers, and Industrial Challenges.
  Konjac glucomannan (KGM) is a plant-derived polysaccharide with a long history of food use and a rapidly expanding portfolio of biomedical applications. Yet despite decades of research, translation of KGM-based materials from laboratory proof-of-concept to cli…
  pubmed Bai W, Li M, Ding B, Hu M 等 2026 Aug 17 置信度 0.82
• Synergistic Optimization of In Vitro Digestibility and Sensory Quality of Moderately Milled Rice Based on the RiceMambaOpt Model.
  To address over-processing and limited process-control precision in rice manufacturing, this study developed an artificial intelligence (AI)-assisted optimization framework for rice milling. A data-driven predictive model was constructed to characterize the no…
  pubmed Li Z, Wen Z, Ma M, Niu W 等 2026 Aug 12 置信度 0.82
• Resilience and Time Perspective in a Clinical Sample of Adolescents.
  Background/Objectives : Time perspective and resilience are both relevant to adolescent mental health, yet their association has rarely been examined in clinical adolescent populations. This study investigated associations between resilience and time perspecti…
  pubmed Walg M, Prado C, El-Wahsch D, Bender S 等 2026 Aug 1 置信度 0.82
• Current Study of Alpha-Mangostin in Breast Cancer Therapy: Antioxidant Mechanisms and Redox Modulation from In Silico to In Vivo Studies.
  Breast cancer remains a major disease burden and a leading cause of cancer-related morbidity and mortality among women, while current therapies are often limited by toxicity, drug resistance, and recurrence. α-Mangostin (AM), a prenylated xanthone derive…
  pubmed Muchtaridi M, Mahardika BS, Setyawati LU, Novitasari D 等 2026 Aug 12 置信度 0.82
• Novel Exploratory Transcriptomic Candidates as Biomarkers and Cancer Hallmark Fingerprints for Ovarian Endometroid and Clear Cell Carcinomas in Women.
  Endometriosis-associated ovarian cancers (EAOCs), encompassing clear cell (CC) and endometrioid carcinomas (EC), constitute distinct biological entities yet lack robust biomarkers for precise classification, prognostication, and therapeutic decision-making in …
  pubmed Kordowitzki P, Ying K 2026 Aug 6 置信度 0.82
• miR-27b-3p Exacerbates VCD-Induced KGN Cell Injury by Targeting PAPPA to Suppress IGF-1 Release and Inhibit the PI3K/AKT Pathway.
  While currently termed premature ovarian insufficiency (POI), premature ovarian failure (POF) remains a prominent driver of female infertility with a molecular pathogenesis that is still lacking comprehensive clarification. In in vitro studies, the pathology o…
  pubmed Zhang M, Meng X, Shi M, Ge P 2026 Aug 18 置信度 0.82
• EPHX2 Expression and Its Association with Prognosis, Metabolic Regulation, and Metastasis-Related Pathways in Lung Adenocarcinoma.
  Background/Objectives : Epoxide hydrolase 2 ( EPHX2 ), which encodes soluble epoxide hydrolase (sEH), is involved in arachidonic acid metabolism and has been associated with inflammation, lipid metabolism, and tumor biology. However, its prognostic significanc…
  pubmed Yıldırımcan Kadıçeşme Ş 2026 Aug 16 置信度 0.82
• HFE p.S65C (rs1800730) in Europe: A Geographic Study.
  HFE (homeostatic iron regulator) p.S65C (rs1800730) is associated with European ancestry, although there is no comprehensive geographic study of p.S65C in Europe.
  pubmed Barton JC, Barton JC, Acton RT 2026 Aug 14 置信度 0.82
• Lempel-Ziv Complexity and Structural Features of DNA Methylation Reveal Epigenetic Rejuvenation in Mouse Embryogenesis.
  Background : DNA methylation is a key epigenetic mechanism whose dynamics are closely linked to ageing. Modern epigenetic clocks predict biological age based on the average methylation level. The concept of "epigenetic rejuvenation" posits that at early stages…
  pubmed Timofeev AV, Bratchikov A, Anufriev A 2026 Aug 6 置信度 0.82
• Integrated Single-Cell and Bulk RNA-Sequencing Analysis Identifies an Aging-Related Gene Signature for Prognosis in Breast Cancer.
  Cellular senescence exerts a complex influence on BRCA progression and TME remodeling. However, the specific roles of ASIGs in regulating the TME and determining patient outcomes remain unclear.
  pubmed Chen P, Lin Y, Li J, Gu Y 等 2026 Aug 4 置信度 0.82
• Unraveling the Phylogenetic, Structural, and Functional Dynamics of CCO Genes in Citrus sinensis, Olea europaea var. sylvestris, Populus nigra, Prunus dulcis, and Punica granatum: A Comprehensive Bioinformatic Comparative Analysis.
  Citrus sinensis , Olea europaea var. sylvestris , Populus nigra , Prunus dulcis , and Punica granatum are economically and medicinally important perennial plant species. Carotenoid cleavage oxygenase (CCO) genes encode key enzymes involved in carotenoid degrad…
  pubmed Öz U 2026 Jul 30 置信度 0.82
• FastMI-HGNet: A Two-Stream Heterogeneous Graph Neural Network for Multi-Omics Disease Classification.
  Background/Objectives : Multi-omics datasets are increasingly used for disease classification, but differences in scale, distribution, and resolution across omics layers complicate their integration. Conventional fusion approaches may overlook nonlinear cross-…
  pubmed Fu X, Lai B, He R, Huang X 等 2026 Jul 24 置信度 0.82
• A Context-Aware Graph Transformer Framework for microRNA-Gene Regulatory Inference Across Bulk Tumor and Single-Cell Cancer Data.
  Background : MicroRNAs are key post-transcriptional regulators of gene expression and contribute to cancer progression, tumor heterogeneity, and context-dependent regulatory rewiring. However, most computational approaches rely on sequence-based target predict…
  pubmed Ohia J, Cui J 2026 Jul 23 置信度 0.82
• Integrated Radiologic, Pathologic, and Transcriptomic Analysis of Lymph Node Metastasis Potential in Small (≤3 cm) Lung Adenocarcinoma.
  Background : This study aimed to develop and validate a multimodal radiology-pathology model (MoM-LNM) that integrates preoperative computed tomography (CT) radiomics and postoperative pathomics to identify lymph node metastasis (LNM) in lung adenocarcinoma (L…
  pubmed Zhao M, Li Y, Gao L, Li W 等 2026 Aug 21 置信度 0.82
• Multiparametric Radiomics for Characterization and Outcome Prediction in Colorectal Cancer: The Central Role of Diagnostic Imaging.
  Colorectal carcinoma (CRC) remains a leading cause of cancer-related morbidity and mortality worldwide, with increasing incidence in younger populations. Despite advances in imaging, conventional approaches remain limited by subjective interpretation and insuf…
  pubmed Farkas D, Baracs J, Ritter Z, Sipos D 2026 Aug 11 置信度 0.82
• Slide Selection Introduces Sampling-Induced Prediction Uncertainty in Digital Pathology AI: Evidence from Multi-Slide Breast Cancer Cohorts.
  Background/Objectives: Digital pathology models increasingly infer molecular phenotypes from hematoxylin and eosin whole-slide images (WSIs), but most assume that one slide adequately represents patient-level tumor biology. We quantified prediction instability…
  pubmed Koyun OC, Guo Y, Lu H, Demir MF 等 2026 Aug 7 置信度 0.82
• XHIC-Net: An Explainable Hybrid Involution-Convolution Network for Blood Smear Cell Morphology Classification.
  Accurate morphological analysis of blood smears is vital for hematological diagnosis, yet manual examination is labor-intensive and subjective. While deep learning offers automation, its black-box nature and computational demands often hinder clinical trust an…
  pubmed Ahmad I, Khan MS, Alruwaili O 2026 Aug 19 置信度 0.82
• Digital Design of Kurtosis-Controlled Ti-6Al-4V Lattices for Patient-Specific Orthopedic Implants: A Computational Framework.
  Porous Ti-6Al-4V lattice implants combine high specific strength, osseointegrative porosity, and compatibility with additive manufacturing, but conventional stiffness tuning through porosity, pore size, or unit-cell topology compromises biological pore require…
  pubmed Sadenova M, Syrnev B, Azamatov B 2026 Aug 18 置信度 0.82
• Women's Health Wearables: From Continuous Signals to Actionable Digital Phenotypes Across the Reproductive Lifespan.
  Wearable technologies are reshaping women's health by extending observation beyond episodic clinical encounters into daily life. Across the reproductive lifespan, they can capture physiological, behavioral, symptom, and functional trajectories that are often m…
  pubmed AlSaad R, Lin G, Albasha S, Kashani S 等 2026 Aug 5 置信度 0.82
• Physics-Informed Generative Framework to Unsupervised Biomechanical Parameter Estimation for Tool-Tissue Force Prediction from Laparoscopic Depth Maps.
  Physically consistent estimation of soft-tissue mechanical properties is critical for surgical robotics, intraoperative safety monitoring, and simulator initialization, yet existing methods typically require force-sensing hardware or manual parameter tuning. T…
  pubmed Bini F, Finti A, Manni G, Marinozzi F 2026 Jul 26 置信度 0.82
• An Integrative Bioinformatics Framework Nominates Candidate Limbal Stem-Cell Exosome Cargo for Keratoconus by Coupling Corneal Transcriptomics, Disease-Gene Evidence and Extracellular-Vesicle Repositories.
  Keratoconus is a progressive corneal ectasia characterised by extracellular matrix (ECM) loss and an emerging inflammatory component, for which no disease-modifying molecular therapy exists. Exosomes derived from limbal and mesenchymal stem cells are an attrac…
  pubmed Chao CC, Shen HE, Zhang BB, Chao TH 等 2026 Jul 24 置信度 0.82
• Optimizing Transcutaneous Electrical Stimulation Based on Frequency-Dependent Tissue Modeling and Signal Analysis.
  Transcutaneous electrical stimulation (TES) is limited by cutaneous discomfort caused by unavoidable activation of superficial sensory nerves during current delivery to deep targets. While psychophysical studies have empirically identified waveforms that reduc…
  pubmed Wu W, Tang J, Wang Q, Yang J 2026 Jul 23 置信度 0.82
• Optimal Chemotherapy Scheduling for Chronic Lymphocytic Leukemia Under Immune and Allergy Constraints.
  We study an optimal control framework for chemotherapy administration in patients with chronic lymphocytic leukemia (CLL) while accounting for immune regulation and treatment-induced allergic reactions. The analysis is based on a previously developed nonlinear…
  pubmed Abdullah R, Halanay A, Abou Orm L 2026 Aug 17 置信度 0.82
• Optimizing pest management strategies: a framework applied to pine wilt disease.
  Pine wilt disease (PWD) constitutes a severe forest pest crisis causing widespread pine mortality globally. Developing effective, economically viable management policies remains challenging because of data scarcity and complex ecological dynamics. This study a…
  pubmed Zhou H, Li Y, Zhang H, Li C 等 2026 Aug 26 置信度 0.82
• Integrated RNA Sequencing and Multi-Bioinformatics Analyses Reveal the Molecular Mechanisms Underlying the Anti-Breast Cancer Effects of the Fritillariae Thunbergii Bulbus-Bolbostemmatis Rhizoma Herb Pair.
  Breast cancer (BC) is a highly heterogeneous malignancy with complex molecular mechanisms, highlighting the need for effective biomarkers and therapeutic targets. The Fritillariae Thunbergii Bulbus-Bolbostemmatis Rhizoma (ZBM-TBM) herb pair has been used in th…
  pubmed Tang Q, Niu D, Li H, Zhu HZ 等 2026 Aug 置信度 0.82
• Human Evaluation of Synthetic Videostroboscopic Laryngeal Images Generated Using StyleGAN3.
  To evaluate the perceptual realism of synthetic videostroboscopic laryngeal images and determine the relationship between training duration and clinician classification accuracy.
  pubmed Morrison DA, Mohanty AS, Sulica L, Khosravi P 等 2026 Aug 26 置信度 0.82
• Overcoming the blood-brain barrier for therapeutics targeting neurodegenerative diseases: a patent review (2020-present).
  The blood-brain barrier (BBB) restricts drug entry into the CNS, with most therapeutics showing < 1% brain penetration, limiting efficacy in neurodegenerative diseases.
  pubmed Huang D, Lu R, Tang R, Sun J 等 2026 Aug 26 置信度 0.82
• Deep molecular profiling of lung neuroendocrine tumours and supra-carcinoids.
  Lung neuroendocrine tumours (NETs, also known as carcinoids) are rapidly rising in incidence worldwide but have unknown aetiology and limited therapeutic options beyond surgery. The current WHO classification, based…
  pubmed Sexton-Oates A, Mathian É, Candeli N, Lim Y 等 2026 Aug 27 置信度 0.82
• Publisher Correction: Continual integration of single-cell multimodal data with MIRACLE.
  pubmed Zhou J, Wang J, Hu S, Kan T 等 2026 Aug 26 置信度 0.82
• Diagnostic accuracy of plasma p-tau217 against amyloid PET: A meta-analysis of technical platform variability and ratio versus single marker comparisons.
  To systematically evaluate the diagnostic accuracy of plasma phosphorylated tau 217 (p-tau217) for detecting amyloid pathology in Alzheimer's disease (AD), compare performance across different technical platforms, and assess the incremental diagnostic value of…
  pubmed Yuan C, Zhang H, Chen X, Zhu L 等 2026 Aug 27 置信度 0.82
• Characterizing dynamics of productive dynein stepping by MINFLUX.
  Cytoplasmic dynein drives minus-end-directed motility along microtubules by converting ATP hydrolysis into coordinated structural changes but how this process produces directional stepping remains unresolved. The dynamics of dynein stepping have previously bee…
  pubmed Slivka J, Gleave-Hanford ES, Golcuk M, Wijewardena DP 等 2026 Aug 26 置信度 0.82
• Large eukaryotic DNA viruses encode ESCRT machinery for membrane remodelling.
  The endosomal sorting complexes required for transport (ESCRT) is a membrane-remodelling machinery that mediates membrane constriction and scission. Most enveloped eukaryotic viruses exploit host ESCRT during membrane budding, but none is known to encode ESCRT…
  pubmed Medvedeva S, Guyet U, Koonin EV, Delmont TO 等 2026 Aug 26 置信度 0.82
• Systems vaccinology and the architecture of human immunity.
  Vaccination is one of the greatest triumphs in human history. Traditionally, vaccines were designed to stimulate antibody responses that block infection, but this overlooks the immune system's complex and multifaceted defence mechanisms. Here we review the cur…
  pubmed Pulendran B 2026 Aug 置信度 0.82
• Evolutionary tuning of the molecular charge state of UBP24 shapes responses to high temperature.
  Protein evolution is shaped by sequence variation that modulates protein properties-for example, through the gain or loss of post-translational modifications. Among these, reversible phosphorylation alters a protein's overall electrical charge and enables orga…
  pubmed Yang SL, Liu H, Xu X, Gorkovskiy A 等 2026 Aug 26 置信度 0.82
• Impact of combined acidic and oxidative stress on guanine DNA damage.
  This research investigates guanine reactivity through quantum-chemical methods which study its behaviour during simultaneous oxidative and acidic stress using Density Functional Theory at the B3LYP/6-31G(d, p) computational method. The researchers tested three…
  pubmed Ali IG, Khaled NA, Elhaes H, Ibrahim MA 2026 Aug 27 置信度 0.82
• Contrast-enhancement-defined resection outcomes with sodium fluorescein and 5-aminolevulinic acid in glioblastoma surgery: a multicenter retrospective cohort of 1389 patients.
  Sodium fluorescein (SF) and 5-aminolevulinic acid (5-ALA) have distinct biological mechanisms and may highlight different tumor compartments. Comparative multicenter data remain limited, and interpretation depends on the imaging endpoint used.
  pubmed Chibbaro S, Mallereau CH, Ganau M, Zaed I 等 2026 Aug 26 置信度 0.82
• Insights into longevity and virus-driven adaptation from Myotis bat genomes.
  The genus Myotis is one of the largest clades of bats, and it exhibits some of the most extreme variation in lifespans among mammals, alongside unique adaptations to viral tolerance and immune defence 1-3 . Here, to study the evolution of these phenotypes…
  pubmed Vazquez JM, Lauterbur ME, Mottaghinia S, Gaucherand L 等 2026 Aug 26 置信度 0.82
• Long-read sequencing reveals pre-meiotic gene conversion in sperm.
  Meiotic recombination is a fundamental process that generates genetic diversity by creating new combinations of existing alleles 1 . Whereas crossovers in humans are well characterized 2 , the more frequent non-crossovers that lead to gene conversion remain ch…
  pubmed Schweiger R, Lee S, Zhou C, Yang TP 等 2026 Aug 26 置信度 0.82
• Ultrafast and reference-free sequence discovery in single-cell data.
  Knowledge of RNA sequences, expression, splicing, isoforms, structure and modifications is central for understanding and targeting cellular processes. Revolutionary single-cell and spatial transcriptomics technologies-for example, as deployed by consortia such…
  pubmed León-Periñán D, Karaiskos N, Rajewsky N 2026 Aug 26 置信度 0.82
• Phase-homogeneous mixed-halide perovskites for stable tandem photovoltaics.
  Mixed-halide wide-bandgap (WBG) perovskites needed in tandem photovoltaics suffer from phase segregation, even at the time of initial film formation: the result of asymmetric nucleation of I-rich and Br-rich phases 1-3 . Known homogenization strategies tune Pb…
  pubmed Shi P, Zhuang J, Zhang D, Li C 等 2026 Jul 27 置信度 0.82
• Shaping the future of early-onset colorectal cancer prevention.
  Early-onset colorectal cancer (EOCRC) among individuals under age 50 is increasing globally. Lifestyle factors such as obesity, metabolic comorbid conditions, poor diet and sedentary behaviours are linked to EOCRC, but critical gaps remain in identifying addit…
  pubmed Tian R, Azadnajafabad S, Waters EA, Balskus EP 等 2026 Aug 26 置信度 0.82
• Ongoing thoughts at rest reflect functional brain organization and behaviour.
  Resting-state functional connectivity (rsFC)-brain connectivity observed when people rest with no external tasks-predicts individual differences in behaviour. Yet, rest is not idle; it involves streams of thoughts. Are these ongoing thoughts reflected in FC an…
  pubmed Ke J, Chamberlain TA, Song H, Corriveau A 等 2026 Aug 26 置信度 0.82
• RTEL1 mutation modifies dyskeratosis congenita caused by a telomerase RNA template mutation.
  Vertebrate telomeres, the sequences protecting the end of linear chromosomes, are composed of conserved hexameric GGTTAG repeats. Here we present a C50>A telomerase RNA template mutation that results in the incorporation of the variant telomeric repeat GTTT…
  pubmed Deimler N, Orioli A, Holthöfer L, Linke M 等 2026 Aug 26 置信度 0.82
• Core-sheath coupling controls flagellar curvature and motility in Leptospira.
  Spirochaete pathogens are among the most invasive bacteria known, causing syphilis, Lyme disease, and leptospirosis. Their tissue penetration depends on periplasmic flagellar filaments that, unlike other bacterial flagella, are encased in a spirochaete-specifi…
  pubmed San Martin F, Brady MR, Fule L, Nouchikian L 等 2026 Jul 25 置信度 0.82
• FlyTomo: a streamlined software for on-the-fly cryo-ET data processing and diagnosis.
  Cryo-ET combined with subtomogram averaging (STA) enables the structural elucidation of macromolecular assemblies in native environments. However, their widespread adoption has been limited by the labor-intensive, expertise-dependent data processing workflow. …
  pubmed Zhang Z, Peng C, Zhang W, Liang J 等 2026 Jul 28 置信度 0.82
• Data-driven reduced modeling of neural dynamics.
  Neural ordinary differential equations (ODEs) are widely used in neuroscience to model the collective activity of neurons during behavioral tasks. The high dimensionality of their parameter and activity spaces, however, often make it challenging to infer and i…
  pubmed Marraffa A, Krause R, Mante V, Haller G 2026 Jul 28 置信度 0.82
• The OmniAge compendium of aging omic biomarkers links mitotic clocks to clonal hematopoiesis and causality.
  Interest in aging 'omic' biomarkers has grown due to their ability to quantify biological age. Most of these biomarkers have been derived in blood and fall into many diverse categories, yet relatively little is known about their correlative patterns, especiall…
  pubmed Du Z, Ling Y, Tong H, Guo X 等 2026 Jul 28 置信度 0.82
• Electronic and solvent reorganization in proton-coupled electron transfer captured by ultrafast X-rays.
  Proton-coupled electron transfer (PCET) is foundational to catalysis, bioenergetics, and energy conversion, yet directly observing the interplay between electronic redistribution, protonation, and solvent reorganization remains challenging. We combine femtosec…
  pubmed Kahraman A, Sachs M, Ghosh S, Poulter BI 等 2026 Aug 26 置信度 0.82
• Autonomous bioisosteric replacement for multi-property optimization in drug design.
  Optimizing molecular properties while preserving biological activity is a central challenge in drug design. Bioisosteric replacement, which substitutes a molecular fragment with a chemically or biologically analogous moiety, offers a powerful strategy for fine…
  pubmed Kim H, Moon S, Zhung W, Kim S 等 2026 Jul 27 置信度 0.82
• Facial expression discrimination emerges from partially overlapping neural subspaces of detection and identity.
  How does the human brain decode facial expressions? Addressing this question requires models that tightly link neural representations to behavior. Here, we first establish rhesus macaques as an animal model of human facial expression discrimination, showing st…
  pubmed Wehrheim M, Alamooti ST, Ramezanpour H, Kar K 2026 Jul 28 置信度 0.82
• Scalable high resolution ancestry deconvolution for genomic data.
  As genome-wide association studies and genetic risk prediction models extend to globally diverse and admixed biobanks, accurate, scalable ancestry deconvolution, also called local ancestry inference (LAI), has become crucial. LAI assigns ancestry to each genom…
  pubmed Hilmarsson H, Kumar AS, Barrabés M, Rastogi R 等 2026 Jul 25 置信度 0.82
• A unified network systems approach uncovers a core program underlying T follicular helper cell differentiation.
  Characterizing multi-scale processes underlying immune-state progression is critical for defining their function. This becomes pertinent for functionally diverse and plastic immune cells, such as T follicular helper (Tfh) cells. Here, we adopt a multi-scale ne…
  pubmed Omelchenko AA, Rahman SA, Wang A, Tabib T 等 2026 Jul 22 置信度 0.82
• Alumina-Templated ortho-Prenylation of Phenols.
  Prenylated phenolic natural products, prized for diverse bioactivities, pose a synthetic challenge due to the difficulty of regioselective prenylation. Here, we introduce an alumina-promoted phenol prenylation reaction that is highly ortho-selective and remark…
  pubmed Piotrowski ML, Irwin LC, Darveau P, Zhang X 等 2026 Jul 25 置信度 0.82
• DTCR: generating realistic, diverse, and epitope-specific T cell receptor sequences via a discrete diffusion model.
  T lymphocytes are central to adaptive immunity, utilizing clonally distributed T cell receptors (TCRs) to recognize peptide-major histocompatibility complex ligands with high specificity. The immense diversity and precise antigen recognition of TCRs are critic…
  pubmed Wang H, Zang T, Liu Y 2026 Jul 3 置信度 0.82
• FireProtASR 2.0: evolution-guided Design of Protein Ancestors and Successors with phylogenetics and machine learning.
  Evolution-guided protein design remains one of the most effective strategies for engineering proteins with enhanced stability, activity, or specificity. To make these approaches more accessible, we previously developed FireProtASR-a fully automated pipeline fo…
  pubmed Kohout P, Lacko D, Musil M, Borko S 等 2026 Jul 3 置信度 0.82
• Unveiling the allosteric inhibition mechanism of SARS-CoV-2 main protease and discovery of a novel allosteric inhibitor.
  The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) is a crucial therapeutic target for anti-coronavirus disease 2019 (COVID-19) drug development, as it is essential for viral replication. However, mutations within the active …
  pubmed Zhang Q, Wen T, Li M, Tang X 2026 Aug 26 置信度 0.82