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• A phylogenomic analysis of ancient transition metal biochemistry.
  Despite seemingly low levels of molybdenum (Mo)/tungsten (W) in the Earth's ancient oceans, these metals play central roles in driving modern biogeochemical cycles. Klos et al. used phylogenomic approaches to reconstruct the Mo/W biochemical repertoire over ap…
  pubmed Dhyani KM, Badran AH 2026 Aug 26 置信度 0.82
• A Eu(III)-MOF for ratiometric fluorescence detection of ATP with a smartphone-integrated sensing platform.
  Sensitive and selective detection of adenosine triphosphate (ATP) is essential for applications in biological analysis, clinical diagnostics, and food safety. Although luminescent probes offer high sensitivity, many systems suffer from poor stability and limit…
  pubmed Zhong X, Xu Y, Jadoun S, Luo J 等 2026 Oct 22 置信度 0.82
• Gram-scale synthesis of neodymium-enriched carbon dots as a CT/NIR-II fluorescence bimodal imaging probe for early diagnosis of acute kidney injury.
  Acute kidney injury (AKI) is a highly morbid and lethal syndrome that is often clinically "silent" in early stages. Multimodal imaging, which integrates complementary structural and functional insights from various techniques, holds great potential to enhance …
  pubmed Xiang K, Liu N, Shu G, Wang G 等 2026 Oct 22 置信度 0.82
• Phytochemical profiling of Manglietia chevalieri and its potential in attenuating pulmonary fibrosis: Insights into bioactive constituents.
  A phytochemical investigation of Manglietia chevalieri (Magnoliaceae), an ornamental species has remained largely unexplored for its chemical constituents and pharmacological potential, led to the isolation and identification of 51 structurally diverse compoun…
  pubmed Long ZJ, Zheng MM, He YH, Tang BX 等 2026 Aug 26 置信度 0.82
• A Meta-analysis of Functional Brain Activity During Valence Processing in Internet Gaming Disorder and Gambling Disorder.
  The intersection of gaming and gambling has gained increasing attention due to their role in addictive behaviours and their effects on brain function. Disadvantageous decision-making, involving continued engagement despite adverse consequences, may reflect dys…
  pubmed Bin Yuan Yeo B, Potenza MN, Tolomeo S 2026 Aug 26 置信度 0.82
• How Phosphorylation of α/β-Tubulin Perturbs Microtubule Structure: A Computational Study.
  Microtubules are cytoskeletal structures composed of polymers of α/β-tubulin heterodimers that enable cell division and motility by a process of alternating episodes of polymerization and depolymerization (dynamic instability). Transition from a po…
  pubmed Ianos A, Osman A, Qiao B, Rotenberg SA 2026 Aug 26 置信度 0.82
• Artificial intelligence across organ-on-a-chip workflows: current implementations and future approaches.
  Organ-on-a-Chip (OoC) systems use microfluidic and tissue engineering techniques to recreate key features of organ microenvironments. They have become a common platform for disease modeling and drug screening. As OoC technologies advance, they generate larger …
  pubmed Li J, Xin J, Qu L, Xu L 等 2026 Aug 26 置信度 0.82
• SeqQC-former: A sequence-quality fusion framework for QC-aware review prioritization of candidate somatic SNVs in cancer genomics.
  The accurate prioritization of candidate somatic single-nucleotide variants (SNVs) remains a challenge due to the substantial variability in sequencing quality across genomic loci. SeqQC-Former is a sequence-quality fusion framework that integrates the local n…
  pubmed Zubair M, Li J, Wang Z, Qian J 2026 Aug 26 置信度 0.82
• Transcriptomic profiling identifies tumor necrosis factor receptor-associated factor (TRAF)-5 expression in human atherosclerotic plaques as a predictor of future cardiovascular events.
  Tumor necrosis factor receptor-associated factors (TRAFs) are cytoplasmic adapter proteins that regulate immune cell signaling downstream of TNF, interleukin-1, and Toll-like receptors. Although preclinical data implicate TRAFs in atherogenesis, their clinical…
  pubmed Gissler MC, Gu X, van der Zalm FBH, Horstmann H 等 2026 Aug 24 置信度 0.82
• Predicting transcriptional regulators in plants in the era of artificial intelligence.
  Identifying transcriptional regulators that control important biological pathways in plants is fundamental to understanding regulatory mechanisms, network hierarchy, and phenotypic variation. This remains challenging because transcription factors (TFs) and the…
  pubmed Ko DK, Brandizzi F 2026 Aug 26 置信度 0.82
• Wing-Wing Interactions at Low Reynolds Numbers in Whitefly Flight.
  At very small scales (∼1 millimeter), flying insects adopt various strategies to accommodate the increased effects of viscosity. One such tiny insect is the tobacco whitefly Bemisia tabaci, which flies using a total of four membranous wings (two forewin…
  pubmed Lionetti S, Williams EJ, Murphy DW, Li C 2026 Jan 12 置信度 0.82
• Variant calling in non-model organisms with snpArcher.
  Population genomic studies in non-model organisms increasingly depend on whole-genome resequencing, yet translating raw reads into reliable variant callsets remains a practical challenge due to the complexity of multi-step bioinformatics pipelines and the abse…
  pubmed Mirchandani C, Omarjee A, Achaz G, Enbody E 等 2026 Aug 26 置信度 0.82
• Bringing Cancer Prevention to Schools: Evaluation of a Novel Teaching Toolkit.
  Purposecancer prevention is key to reduce disease burden, but is often dependent on individual behavioral choices, many of which are adopted early on during adolescence. A novel cancer prevention teaching toolkit, designed for this audience and the educational…
  pubmed Gomes AA, Ribeiro N, Oliveira P, Ribeiro P 等 2026 Aug 26 置信度 0.82
• Metal-free redox active covalent organic frameworks for electrocatalytic oxygen reduction reaction.
  Designing efficient, metal-free covalent organic framework (COF) electrocatalysts is a promising strategy for the oxygen reduction reaction (ORR) due to their structural tunability and stability. Herein, we report two redox-active donor-acceptor COFs, TAPA-DHT…
  pubmed Mishra B, Samui S, Ghosh S, Dutta S 等 2026 Aug 28 置信度 0.82
• Prefoldin function links meiotic chromosome segregation with cellular remodeling and reveals tubulin sensitivity of the meiotic spindle.
  Faithful chromosome segregation is essential for producing viable gametes during meiosis, a specialized type of cell division relative to mitosis. Here we identify Gim3, a subunit of the ubiquitously expressed and conserved prefoldin complex, as a critical reg…
  pubmed Kuwayama N, Styler BS, Stekovic B, Sakharova H 等 2026 Aug 28 置信度 0.82
• Truthful visualizations for mass spectrometry imaging enable high-spatial-resolution interactive m/z mapping and exploration.
  Mass spectrometry imaging (MSI) produces high-dimensional molecular data, but practical interpretation remains limited by visualizations that incompletely preserve global structure. We present MSI-VISUAL, an open-source framework for interactive MSI analysis t…
  pubmed Gildenblat J, Pahnke J 2026 Aug 28 置信度 0.82
• A 3D human retina model reveals a non-cell-autonomous and non-neuronal mechanism of photoreceptor loss in a lysosomal storage disorder.
  Disruption of the photoreceptor-retinal pigment epithelium (RPE) interface, with loss of photoreceptor outer segments (POSs) in the retina, is a pathological hallmark of several neurodegenerative and retinal diseases, including lysosomal storage disorders like…
  pubmed Han J, Foley N, Dalvi S, Tang JAH 等 2026 Aug 26 置信度 0.82
• Robot in a crib: How a playing robot helps us understand sensorimotor contingency learning.
  Learning sensorimotor contingencies-that is, the link between one's actions and their sensory effects-is fundamental to developing body knowledge, understanding causality, and developing a sense of agency. In developmental psychology, this process is classical…
  pubmed Spisak J, Tcaci Popescu S, Rustler L, Wermter S 等 2026 Aug 26 置信度 0.82
• Simulation and inference methods for non-Markovian stochastic reaction networks.
  Stochastic models of reaction networks are widely used to capture intrinsic noise in complex systems in the life sciences. Typical formulations of these models are based on Markov processes for which there is extensive research on efficient simulation and infe…
  pubmed Steele TP, Warne DJ 2026 Aug 26 置信度 0.82
• Evidence of genetic susceptibility to immune-related dermatitis in patients with melanoma treated with immune checkpoint inhibitors.
  Immune checkpoint inhibitor (ICI)-mediated dermatitis is a common treatment-related adverse event. We conducted single-nucleotide polymorphisms (SNPs)-array genotyping on germline DNA from 744 participants in a phase three adjuvant trial of ipilimumab in melan…
  pubmed Tarhini AA, Khaksar MA, Chen Z, Lee SJ 等 2026 Oct 1 置信度 0.82
• A Propeller with a Flexible Twist: A Computational Analysis of Intrinsically Disordered Regions in PIEZO Gating and PIEZO-Associated Channelopathies.
  Mechanosensitive ion channels PIEZO1 and PIEZO2 are key mediators of mechanotransduction, which converts physical forces into cellular signals involved in proprioception, touch, vascular function, and other physiological processes. Mutations in human PIEZO pro…
  pubmed Shukla S, Elzy M, Shrestha A, Uversky VN 2026 Aug 11 置信度 0.82
• Immediate Rehabilitation of Critical-Size Gunshot- and Mine Blast-Related Maxillary Defects Using Cortically Anchored Single-Piece Implants: Two Case Reports.
  Background and Clinical Significance: Implant rehabilitation of patients with acquired maxillofacial defects remains challenging, particularly following high-energy war-related trauma. Gunshot and mine blast injuries frequently result in extensive hard and sof…
  pubmed Vares Y, Vares Y, Pałka Ł, Olszewski R 2026 Aug 6 置信度 0.82
• Top-down feedback in deep neural networks leads to functional differences during audiovisual integration.
  Artificial neural networks (ANNs) are an important tool for studying neural computation, but many features of the brain are not captured by standard ANN architectures. One notable missing feature in most ANN models is top-down feedback, that is projections fro…
  pubmed Tugsbayar M, Li M, Muller EB, Richards B 2026 Aug 26 置信度 0.82
• Integrative Epigenomics: Bioinformatics Strategies for Multi-Omics Data Analysis in Health and Disease.
  Background: Epigenomics has emerged as an essential field in modern molecular biology, providing a critical layer of gene regulation. DNA methylation, histone modifications and alterations to the chromatin accessibility of DNA have been widely associated with …
  pubmed Baruri S, Batra L, Adhikari S, El-Baz A 2026 Aug 7 置信度 0.82
• DeepPathway: Predicting Pathway Expression from Histopathology Images.
  Spatial transcriptomics (ST) technologies provide spatially resolved gene expression along with image data, allowing the integrative analysis of complex tissue microenvironment. Despite their potential, the widespread adoption of ST remains limited due to high…
  pubmed Ahsan MA, Hanley KP, Fergie M, O'leary C 等 2026 Aug 26 置信度 0.82
• STcompare: comparative spatial transcriptomics data analysis of structurally matched tissues to characterize differentially spatially patterned genes.
  Comparative analysis of spatial transcriptomics (ST) data is needed to identify genes that spatially change in their expression patterns between conditions, such as in diseased versus healthy tissues. Existing methods generally fail to distinguish changes in s…
  pubmed Clifton K, Jiang V, Dos Santos Peixoto R, Singh S 等 2026 Aug 26 置信度 0.82
• Cystinosin/Ers1 functions in redox homeostasis in the early secretory pathway.
  Cystinosis is an autosomal recessive inherited disorder caused by mutations in the CTNS gene, which encodes the highly conserved lysosomal membrane protein, cystinosin. Cystinosin mediates proton-coupled transport of cystine, the oxidized dimer of cysteine. Lo…
  pubmed Zhu J, Seetharam SM, Bowerman J, Baik S 等 2026 Aug 26 置信度 0.82
• A genetic program for rapid initiation of axillary meristems at the onset of flowering.
  Shoot branching patterns and their diversity arise from variable activities of axillary meristems (AMs). A common feature of flowering plants is delayed AM initiation and growth during the vegetative phase, followed by a sudden and rapid acceleration of apical…
  pubmed Chongloi GL, Meir Z, Amsellem Z, Aviezer I 等 2026 Sep 置信度 0.82
• Quinoline and Phthalimide Substituted Silicon Phthalocyanines as Multi-Target Inhibitors of Cholinesterases and Carbonic Anhydrases.
  Two novel axially substituted silicon phthalocyanines bearing 5,7-dichloro-8-hydroxy-2-methylquinoline (1a) and N-(hydroxymethyl)phthalimide (2a) moieties were synthesized and characterized by UV-Vis, FT-IR, 1 H NMR, and mass spectrometry techniques. The biolo…
  pubmed Ünlü S, Köksal Z, Kırboğa KK, Tuncel Elmalı F 2026 Sep 置信度 0.82
• Evidence of curvature bias and local POPG recruitment during surface-bound interactions of a cationic peptide with POPC/POPG membrane.
  Antimicrobial peptides (AMPs) constitute an important class of antibacterial molecules whose mechanisms of action remain incompletely understood. Among the different stages of peptide-membrane interaction, membrane curvature has been recognized as a key physic…
  pubmed Nunes LO 2026 Aug 26 置信度 0.82
• Investigating the Binding Mode of a Naphthol-Based Inhibitor Targeting SARS-CoV-2 Main Protease.
  Regardless of the massive global efforts to combat the virus causing SARS-CoV-2 syndrome, the infection remains a substantial health challenge worldwide in the years following 2019. To this direction, targeting the main viral protease M pro has been proposed a…
  pubmed Akrani I, El Kilani H, Touret F, Kouvali S 等 2026 Aug 27 置信度 0.82
• Quantitative comparison of fungal genome assembly strategies using short and long reads from simulated and empirical sequencing data.
  High-quality fungal reference genomes are essential for comparative, functional and evolutionary studies, yet fungal genome features such as repeats, structural rearrangements, accessory chromosomes and intron-rich genes can complicate genome assembly and the …
  pubmed Silva GAA, Folorunso TR, Eckhardt LG, Willoughby JR 2026 Aug 置信度 0.82
• Heavy Metal-Induced Genotoxic Damage in Chelon auratus: Evidence from a Coastal Gulf Ecosystem.
  Estuarine and river-influenced coastal ecosystems are recognized as important sinks and channels for transfer of heavy metals into the marine environment. Continuous intake of metal pollutants could create chronic exposure situations, perhaps leading to molecu…
  pubmed Turan C, Ergenler A, Koç ZA, Turan F 2026 Aug 19 置信度 0.82
• CSTAP: An Event-Conditioned Protocol for Toxicological Activation Potential in Coastal Sediments.
  Coastal sediments can store contaminants for decades and become exposure sources when disturbance alters partitioning, transport, or biological contact. We propose the Coastal Sediment Toxicological Activation Protocol (CSTAP), a theoretical and empirically te…
  pubmed Somma R, Spoto SE 2026 Aug 3 置信度 0.82
• MDCT Morphometry of the Thoracolumbar Junction in a Turkish Cohort: Surgical, Radiological, and Forensic Implications.
  Background : The thoracolumbar junction (TLJ) includes the T11-L2 vertebral segments. It is a pivotal biomechanical transition zone between the rigid thoracic spine and the more mobile lumbar spine. Accurate morphometric data from this region are crucial for u…
  pubmed Duman L, Sirzai EY 2026 Jul 28 置信度 0.82
• Reliability of Sprint Time and Force-Velocity Profiles During Sprint Acceleration in Elite Rugby Union Players: Inter-Trial Reliability of Linear Encoder, GPS, Timing Gates and Video Analysis.
  This study aimed to test the reliability of measurements obtained using different technologies for sprint time and force-velocity profiles during sprint running. Seventeen elite rugby union players completed three experimental sessions, separated by one week. …
  pubmed Grimbert Le Mer S, Vachon A, Mujika I, Berryman N 等 2026 Aug 6 置信度 0.82
• Exceptional Parental Longevity and Onset of Morbidity and Mortality Across Cohorts.
  Centenarian lifespan extension is frequently accompanied by delayed onset of aging-associated diseases. Understanding the transgenerational patterns of this phenomenon is crucial for informing investigations of genetic and environmental factors that promote he…
  pubmed Reed ER, Wysocki M, Gal M, Aleksic S 等 2026 Aug 3 置信度 0.82
• Toxicity and DNA Adduct Formation Reinforce AI-Guided Prediction of Aflatoxin B1 Bioactivation in VERO E6 Cells.
  VERO cells, derived from the kidney epithelium of the African green monkey, are widely used in virology, but their ability to metabolize xenobiotics is not fully understood. Since cytochrome P450 (CYP) enzymes participate in xenobiotic metabolism, we investiga…
  pubmed Sangwan B, Okoro U, Atteck I, Jaruga P 等 2026 Aug 4 置信度 0.82
• Discovery of Protein-Derived Candidate Anticancer Peptides from Toad Poison (ChanSu) Using an Integrated Proteomics and Bioinformatics-Guided Strategy.
  Toad poison (ChanSu), a traditional animal-derived medicine, has long been used in East Asian medical systems for the treatment of inflammatory conditions and tumor-related disorders. While bufadienolides have been extensively investigated as its major bioacti…
  pubmed Chen J, Wang B, Xie Y, Xue F 等 2026 Jul 27 置信度 0.82
• Identification and Thermal Stability Modification of a Zearalenone Lactone Hydrolase ZHD30L.
  In this study, a previously uncharacterized zearalenone lactone hydrolase, ZHD30L, from Knufia peltigerae was identified and characterized, and semi-rational design was employed to enhance its thermostability. The results indicate that the optimal reaction con…
  pubmed Liu X, Zhao F, Sahibzada KI, Zhang Y 等 2026 Jul 26 置信度 0.82
• Integrated Cardiopulmonary Profile as an Additive Signal in Patients Evaluated for Suspected Newly Detected Atrial Fibrillation.
  Atrial fibrillation (AF) is associated with atrial remodelling, hemodynamic stress, and complex cardiopulmonary interactions. While natriuretic peptides and echocardiographic abnormalities are established markers of AF-related substrate, the contribution of sp…
  pubmed Kundnani NR, Sharma A, Rosca CI, Velimirovici MD 等 2026 Aug 21 置信度 0.82
• The PD Effluentome-A Multi-Omics Atlas Defining the Composition, Transport Dynamics, and Molecular Origin of Peritoneal Dialysis Effluent.
  Background : Peritoneal dialysis (PD) effluent of kidney failure patients represents an accessible liquid biopsy of the peritoneal cavity, yet the mechanisms determining its molecular composition remain poorly understood. We applied an integrative multi-omics …
  pubmed Herzog R, Eibensteiner F, Wiesenhofer FM, Daniel-Fischer L 等 2026 Aug 19 置信度 0.82
• Identification and Computational Analysis of BRCA1 Variants in Mexican Women from Jalisco, Mexico, with Breast and Ovarian Cancer.
  Breast and ovarian cancer are among the most common neoplasms in women, and germline variants in the BRCA1 gene markedly increase the risk of developing them. Despite existing studies, the frequency and spectrum of BRCA1 variants in women from Jalisco, Mexico,…
  pubmed Gallegos-Arreola MP, Garibaldi-Ríos AF, Dávalos-Rodríguez IP, Magaña-Torres MT 等 2026 Aug 1 置信度 0.82
• Digital Hesitancy Among Nurses and Physicians in Anesthesia and Intensive Care: A Cross-Sectional Study from Romania.
  Background and Objectives: Digitalization studies often emphasize perceived benefits while overlooking professionals who cannot determine whether digital tools are useful. This study quantified digital hesitancy among anesthesia and intensive-care professional…
  pubmed Vernic C, Bedreag O, Sulițanu DC, Petre I 等 2026 Aug 19 置信度 0.82
• Pharmacokinetic Profiling Evaluation of Ruditapes philippinarum Polysaccharide.
  Oral administration represents the primary route for administering polysaccharides. Pharmacokinetics serves as a critical bridge between the administration of polysaccharides and the manifestation of their bioactivities. However, the pharmacokinetic behavior o…
  pubmed Liu MY, Yin DL, Yu J, Wang WX 等 2026 Aug 11 置信度 0.82
• Cytotoxic Activity and In Silico Study of Secondary Metabolites Derived from Dactylospongia elegans.
  Breast cancer remains a major global health burden. Dactylospongia species have been explored for their cytotoxic potential. This study aims to evaluate the cytotoxic potential of compounds derived from the marine sponge Dactylospongia elegans . Dactylospongia…
  pubmed Hadisaputri YE, Hidayat NN, Murniasih T, Hadi A 等 2026 Aug 4 置信度 0.82
• Cold Atmospheric Plasma Potentiates the Photodynamic Effects of Protoporphyrin IX-Loaded Mesoporous Silica-Coated Iron Oxide Nanoclusters in HaCaT Cells.
  Photodynamic therapy (PDT) is a reactive oxygen species (ROS)-based treatment modality whose efficacy is often limited by poor photosensitizer stability and delivery. In this study, mesoporous silica-coated iron oxide nanoclusters (MNCs) were synthesized and l…
  pubmed Erdag D, Basoglu H, Yalcintepe L, Toprak MS 2026 Aug 17 置信度 0.82
• Spasmolytic Activity of Plant-Mediated Silver Nanoparticles from Fenugreek Seeds: Impact of Geographic Origin and Extraction Solvent.
  Fenugreek is a widely used aromatic herb valued as a food ingredient. Fenugreek seeds and leaves are rich in antioxidants and bioactive compounds that support overall health, particularly gastrointestinal function. The present paper describes a green synthesis…
  pubmed Ivanova A, Ivanova S, Petrov D, Gledacheva V 等 2026 Aug 17 置信度 0.82
• Plant-Mediated Nanomaterials for Photoprotection: Mechanistic Insights, Current Advances, and Future Perspectives.
  Ultraviolet (UV) radiation is a major environmental factor contributing to photoaging, oxidative stress, inflammation, DNA damage, and photocarcinogenesis. Conventional UV filters, although widely used in sunscreen formulations, are associated with limitations…
  pubmed Moradi N, Bright R 2026 Aug 10 置信度 0.82
• Long-Read RNA Sequencing Reveals an Isoform Switching Pattern in Healthy Microglial Cell Lines Exposed to Radiotherapy.
  Background/Objectives : Radiotherapy (RT) is a fundamental treatment for brain tumors but often leads to long-term neurotoxicity, partly caused by microglial dysfunction. In this study, we used long-read RNA sequencing (LR-RNA-seq) to map the isoform-specific …
  pubmed Zuppelli T, Orlando L, Conti GN, Lombardo SP 等 2026 Aug 6 置信度 0.82
• Spatial Metabolomics and Single-Cell Virtual Knockout Screening Reveal Solanesol Improves Parkinson's Disease-like Pathology Based on Lipid Inflammation Mechanism.
  Background : Parkinson's disease (PD) is characterized by a complex interplay of dopaminergic degeneration, glial activation, and lipid metabolic dysregulation. However, accurately describing how natural product interventions remodel these pathologies across d…
  pubmed Li Q, Xu L, Zhu M, Wang G 等 2026 Jul 31 置信度 0.82
• AI-Assisted Spatial Metabolic Engineering in Plants: Integrating Flux Design, Spatial Omics, and Synthetic Biology.
  Background: Plant synthetic biology reprograms metabolic networks for the sustainable production of high-value compounds. Recent computational advances incorporate machine learning to accelerate the design-build-test-learn (DBTL) cycle, enabling more predictab…
  pubmed Chen H, Yang J, Du M 2026 Jul 23 置信度 0.82
• Functional Biomaterials and 3D Bioprinting Approaches for Temporomandibular Joint Reconstruction: A Narrative Review.
  The temporomandibular joint (TMJ) is a highly specialized synovial joint responsible for essential functions such as mastication, speech, and swallowing. Owing to its unique anatomical organization, complex biomechanics, and heterogeneous tissue composition, r…
  pubmed Shopova D, Aleksandrov S, Hristozova MI 2026 Aug 8 置信度 0.82
• Mechanotransductive Osteogenesis Through Microarchitectural Stabilization in an Injectable Hydrogel-Mineral System.
  In the contemporary era of minimally invasive surgery, injectable biomaterial scaffolds have demonstrated significant potential in bone tissue engineering (BTE). Completely injectable hydrogel substratum with microscale bone graft particulates delivered throug…
  pubmed Kim YK, Niu W, Love CJ, Spector M 2026 Aug 6 置信度 0.82
• Advances in Machine Learning-Enhanced PBPK Models for Brain-Targeted Drug Delivery via Nanocarriers: A Comprehensive Review.
  Nanostructured drug-delivery materials-liposomes, polymeric nanoparticles, dendrimers, and inorganic carriers-have become central to pharmaceutical strategies for crossing the blood-brain barrier (BBB), where most candidate therapeutics fail to reach their tar…
  pubmed Hu H, Wang Y 2026 Aug 3 置信度 0.82
• Censored-Data-Aware Screening of Hazardous Metal(loid)s in Wild Mushrooms from Urban and Peri-Urban Green Spaces: Multielement Fingerprints and Adult Exposure Assessment.
  Wild mushrooms collected from urban and peri-urban green spaces may represent environmentally exposed biological matrices for hazardous metal(loid)s, but their interpretation is complicated by taxonomic heterogeneity, tissue partitioning and left-censored anal…
  pubmed Peña-Fernández A, Lobo MC, Peña Fernández MÁ, Torrado Durán G 等 2026 Jul 30 置信度 0.82
• Large-Scale Data Analysis of Post-Traumatic Stress Disorder (PTSD) Through GWAS Fine-Mapping and Systems Biology.
  Background/Objectives : Post-Traumatic Stress Disorder (PTSD) is a complex psychiatric condition with a strong polygenic and stress-related biological basis. Although Genome-Wide Association Studies (GWAS) have acknowledged abundant risk variants, translating …
  pubmed Sharafshah A, Hanna C, Lewandrowski KU, Gold MS 等 2026 Aug 12 置信度 0.82
• Inflammation Course and Skeletal Muscle Wasting Correlation During the First Week in ICU: A New Approach for Personalised Feeding of Critically Ill Patients?
  Background : Critically ill patients undergo rapid and clinically significant skeletal muscle loss during the first week of ICU admission, driven by a complex interplay of systemic inflammation, neuroendocrine dysregulation, and accelerated protein catabolism.…
  pubmed Gremese G, Comuzzi M, Danielis M, Piani T 等 2026 Jul 30 置信度 0.82
• AWTI-Net Enables Accurate and Interpretable Functional Assessment of Disease-Associated LncRNA Mutations.
  Long non-coding RNA (lncRNA) variants contribute to human disease, yet systematic evaluation of their functional impact is limited by the lack of high-quality benchmark datasets for computational tool development. To address this, we curated three comprehensiv…
  pubmed Zhu H, Li D, Jiang Z, Yang M 等 2026 Aug 26 置信度 0.82
• Pharmacological evaluation of Schinus terebinthifolius leaf polysaccharides: from chemical profiling to anti-inflammatory and wound-healing applications.
  This study aimed to characterize the physicochemical profile of polysaccharides from Schinus terebinthifolius leaf (PSTL) and evaluate their antioxidant, analgesic, anti-inflammatory, and wound-healing potential. Colorimetric analyses revealed a total carbohyd…
  pubmed Bedoui A, Rjeibi I, Elfalleh W, Feriani A 等 2026 Aug 26 置信度 0.82
• Hypoxia-Driven Mechanisms in Ischemic Heart Failure: A Bioinformatics, Machine Learning and Bayesian Network Study.
  Hypoxia is a critical determinant in the etiology and progression of ischemic heart failure, but its underlying molecular mechanisms and regulatory interactions remain largely enigmatic. in our study, we employed differential analysis, coupled with WGCNA and t…
  pubmed Han Q, Fan R, Ma J, Yuan H 等 2026 Aug 26 置信度 0.82
• Integrative chemical profiling combined with molecular docking, molecular dynamics simulations, ADMET, and DFT analysis reveal the anti-infective and antioxidant potential of Pulicaria incisa (Lam.) DC. essential oil supported by experimental validation.
  The discovery of novel anti-infective agents through integrated in vitro and in silico approaches is crucial to combat the increasing global burden of infectious diseases. Accordingly, this study aimed to investigate the antimicrobial (ESKAPE pathogens and fis…
  pubmed Snoussi M, Noumi E, Alsenani Q, Khitouni M 等 2026 Aug 26 置信度 0.82
• Exploring the Potential of Synechocystis sp. PCC 6803 for P(3HB-co-3HV-co-4HB) Terpolymer Production.
  The increasing environmental impact of plastic pollution has intensified the demand for sustainable alternatives, such as polyhydroxyalkanoates (PHA). Among different types of PHAs, terpolymer demonstrates superior polymer properties compared to polyhydroxybut…
  pubmed Tanweer S, Panda B 2026 Aug 26 置信度 0.82
• In Silico Discovery and in vitro Evaluation of the Antifungal and Cytotoxicity Properties of Zeaxanthin and β-Carotene.
  The increasing drug resistance in pathogenic fungi has highlighted the need to identify novel molecular targets and safer antifungal compounds. In this study, a target-based chemoinformatics approach was employed to identify mannosyltransferase 2 (MNT2), key c…
  pubmed Panahi Moghadam M, Sardari S, Norouzi Nejad M, Rahmati M 等 2026 Aug 26 置信度 0.82
• Computational Design and Expression of Headless Influenza Hemagglutinin Antigens Toward a Modular Universal Nanoparticle Vaccine.
  The elicitation of broadly neutralizing antibodies against conserved antigenic epitopes has been a focus of universal vaccine research. To facilitate immunofocusing on the conserved influenza hemagglutinin (HA) stalk, we designed headless trimeric antigens, in…
  pubmed Ovchinnikov V, Karplus M 2026 Jul 27 置信度 0.82
• Distinguishing Organizing Pneumonia from Malignancy During Cancer Surveillance: Predominant Diagnostic Value of Imaging over Systemic Inflammatory Biomarkers.
  Background: Distinguishing organizing pneumonia from recurrent malignancy in patients undergoing cancer surveillance remains a major clinical challenge. Although inflammatory biomarkers have emerged as potential diagnostic tools, their incremental value beyond…
  pubmed Yesilcay HB, Aydin AA 2026 Aug 20 置信度 0.82
• Risk-Aware Computational Prioritization and Validation Route Design for Medicine-Food Homology Plant Compounds in a Parkinson's Disease Context.
  Network pharmacology studies of medicine-food homology plants have identified broad injury response pathways and hubs that cannot support compound-level or Parkinson's disease (PD)-specific claims. We developed a traceable, non-weighted framework that separate…
  pubmed Zou J, Wang S, Yong J, Yan L 等 2026 Aug 10 置信度 0.82
• Eisenia andrei and Tenebrio molitor Divergently Restructure the Bacteriome and Mycobiome of Sewage Sludge with Contrasting Biosafety Consequences.
  The use of invertebrates for sewage sludge bioconversion offers a sustainable strategy for waste valorization, yet species-specific effects on microbial communities and biosafety remain unclear. Here, we compared the impacts of the earthworm Eisenia andrei (Ea…
  pubmed Mancilla E, Pérez-Losada M, Aira M, Domínguez J 2026 Aug 3 置信度 0.82
• An Evidence-Tiered Biomimetic Design Space Workflow for the Conceptual Design of Elderly-Care Robots.
  Early-stage elderly-care robot design requires biological analogies to be translated without turning qualitative inspiration into unvalidated numerical evidence.
  pubmed Zang W, Xiao C, Seong D 2026 Aug 13 置信度 0.82
• Biomimetic Mustard Seed-Inspired Brush-Free Alternative for Effective Endoscope Channel Cleaning and Decontamination.
  Inadequate cleaning of flexible endoscope channels remains a major cause of healthcare-associated infections despite established reprocessing protocols. We developed biomimetic carbon balls inspired by mustard seed surface features as a brush-free adjunct for …
  pubmed Lim SD, Cho H, Choi SH, Kim HG 等 2026 Aug 10 置信度 0.82
• Pretraining of Embodied Recurrent Networks Bridges the Gap Between Artificial and Cortical Neural Activities.
  Task-driven recurrent neural networks (RNNs) have been widely employed as tools for investigating neural dynamics in neural motor control research by modeling the motor cortex. RNNs are often implicitly assumed to learn the underlying computational mechanisms …
  pubmed Bu X, Jiang H, Guo T, Li H 等 2026 Aug 9 置信度 0.82
• A Comprehensive Review of Bio-Inspired Surface and Morphological Structures for Enhancing Aerodynamic and Hydrodynamic Performances: Trends, Mechanisms, and Future Horizons.
  Bio-inspired wing designs have emerged as a revolutionary approach to enhancing aerodynamic and hydrodynamic performance across a wide range of engineering applications. This review presents a comprehensive exploration of the biological principles, physical me…
  pubmed Shaik M, Huang WX 2026 Jul 23 置信度 0.82
• Mechanics-AI: A Bio-Inspired Physics Intelligence Pipeline for Cross-Domain Engineering Prediction and Sustainable Design.
  Mechanistic simulation and machine learning are powerful but complementary tools: physics-based simulation is interpretable yet computationally expensive and blind to real-world context, whereas machine learning is fast but data-hungry and opaque. Biological s…
  pubmed Wei Y, Fei W, Wang J, Bi L 2026 Jul 23 置信度 0.82
• Stimulation of Adult Muscle Stem Cells with BMPs Results in Direct Activation of Notch Pathway Genes.
  Muscle stem cells (MuSCs) are the cellular source for the generation and regeneration of skeletal muscle. Proper muscle growth requires precise control over the differentiation and self-renewal of MuSCs. Signaling systems, such as bone morphogenetic proteins (…
  pubmed Lange BKA, Polydorou I, Huryn V, Georgieva AM 等 2026 Aug 19 置信度 0.82
• A Regulatory Element in the Intrinsically Disordered C-Terminal Region of LMTK3 Modulates Its Kinase Domain Interactions and Breast Cancer Phenotypes.
  Lemur tail kinase 3 (LMTK3) is an oncogenic Ser/Thr kinase implicated in breast cancer (BC) progression, therapy resistance, and poor clinical outcomes, yet the molecular mechanisms governing its regulation remain poorly understood, particularly the role of it…
  pubmed Lauer Betrán A, Agnarelli A, Samuels M, Vella V 等 2026 Aug 17 置信度 0.82
• From Neurovascular Compression to Neural Hyperexcitability: Integrating Microanatomy, Electrophysiology, and Computational Neuroscience to Understand Trigeminal Neuralgia and Hemifacial Spasm.
  Neurovascular compression syndromes (NVCS), including trigeminal neuralgia (TN) and hemifacial spasm (HFS), are characterized by disabling symptoms caused by vascular compression of cranial nerves. Although microvascular decompression is an established treatme…
  pubmed Okuhata H, Aihara M, Oya S, Nagai R 等 2026 Aug 10 置信度 0.82
• Caulerpa peltata extract protects against Dextran sodium sulfate-induced acute ulcerative colitis via modulating Nrf2 pathway.
  Ulcerative colitis (UC) is one of the inflammatory bowel diseases (IBD) and poses an increasing public health issue around the world because of the presence of genetic, immunological, and environmental causes. Antioxidants and anti-inflammatory therapy targeti…
  pubmed Chanbasha YB, Ragunath M, Pandurangan AK 2026 Aug 26 置信度 0.82
• Proteomic Immune Signatures of Severe HIV-Associated Tuberculosis in Sub-Saharan Africa: A Prospective, Multicenter Analysis From Uganda.
  Severe tuberculosis (TB) is a major cause of critical illness and death in people living with HIV (PLWH) worldwide. Despite this, the immunopathology of severe HIV-associated TB (HIV/TB) is poorly understood. We aimed to identify an immunopathologic signature …
  pubmed Ross JE, Tomoiaga AS, Owor N, Lu X 等 2026 Sep 1 置信度 0.82
• Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate ovarian aging by inhibiting ferroptosis.
  Ovarian aging is characterized by a decline in oocyte quantity and quality, often driven by oxidative stress and cellular damage. Human umbilical cord mesenchymal stem cell-derived exosomes (hUC-MSC-Exos) have emerged as a potent cell-free therapy for regenera…
  pubmed Li CJ, Lin LT, Lin PH, Wang B 等 2026 Aug 26 置信度 0.82
• Gallic Acid-Rich Ephedra alata: Integrated Phytochemical Profiling, Aromatase Docking, and Optimized Extraction via Box-Behnken Design.
  This study investigated the phenolic composition and antioxidant potential of E. alata using an integrated approach combining phytochemical profiling, molecular docking, and Box-Behnken optimization of extraction conditions. Stem extracts were prepared by mace…
  pubmed Chekroun-Bechlaghem N, Belyagoubi-Benhammou N, Kaid Z, Zitouni A 等 2026 Aug 置信度 0.82
• Decoding neuronal vulnerability: Multidimensional analysis of D1R- and D2R- medium-sized spiny neurons in Huntington's disease.
  Understanding the molecular mechanisms driving selective neuronal vulnerability to different neurodegenerative disorders remains a crucial, unsolved question. Here, we explored the case of Huntington's disease (HD), where the striatum and, specifically, dopami…
  pubmed Bergonzoni G, Pellegrini M, Savino A, Lazioli M 等 2026 Aug 26 置信度 0.82
• Updating the RZooRoH Package for the Analysis of Inbreeding, Identity-By-Descent and Relatedness From Genomic Data.
  The RZooRoH R package was implemented to characterize individual inbreeding levels. It identifies DNA segments inherited twice from a common ancestor through different paths, which are known as homozygous-by-descent (HBD) segments. The package accepts differen…
  pubmed Forneris NS, Faux P, Gautier M, Druet T 2026 Aug 置信度 0.82
• Emerging experimental and computational methods for studying redox-regulated structural transitions.
  Thiol-based redox switches utilize the unique nucleophilicity of cysteine and selenocysteine to dynamically link real-time cellular redox fluctuations to metabolic regulation and signaling pathways. Capturing the precise atomic-level thermodynamic and kinetic …
  pubmed Rass T, Reichmann D, Erdős G 2026 Aug 26 置信度 0.82
• Bioinformatics and Machine-Learning Identification of Pulmonary Hypertension Biomarkers and Candidate Therapeutic Compounds.
  This study aimed to identify pulmonary hypertension (PH)-associated molecular biomarkers and candidate small-molecule compounds using public transcriptomic data and independent validation resources. Three Gene Expression Omnibus datasets (GSE22356, GSE33463, a…
  pubmed Jiang C, Liang J, Jiang X 2026 Aug 25 置信度 0.82
• Targeting Ferroptosis and Cuproptosis in Ulcerative Colitis: Findings from Comprehensive Bioinformatics and Experimental Validation.
  Ulcerative colitis (UC) is a persistent intestinal disorder with an incompletely defined pathogenesis and increasing prevalence and hospitalization rates in newly industrialized countries. In UC, excessive intestinal epithelial cell death disrupts the mucosal …
  pubmed Chen X, Hu Z, Wang Q, Sui N 2026 Aug 25 置信度 0.82
• Suppressed cGAS-STING DNA Sensing Drives Immune Evasion in Anaplastic Thyroid Cancer.
  Anaplastic thyroid cancer (ATC) is a highly lethal malignancy with poor survival and limited therapeutic options. The mechanisms driving immune evasion in ATC remain poorly understood. The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pat…
  pubmed Zhu XG, Acharya M, Hwang E, Wong N 等 2026 Aug 26 置信度 0.82
• MixedUpParents: A New and Improved Method for Genetic Parentage Assignment in Admixed Populations.
  Hybridization is ubiquitous throughout the tree of life. Its presence in genetic datasets often violates model assumptions or leads to erroneous inferences. Nonetheless, few parentage assignment methods have been developed that account for hybridization or adm…
  pubmed Grummer JA, Anderson EC, Luikart G 2026 Aug 置信度 0.82
• Advances in Single-Cell Metabolomics and Their Applications in Disease Biology.
  Single-cell metabolomics (SCM) provides a functional view of cellular heterogeneity by measuring metabolic states at cellular or subcellular resolution. Unlike bulk metabolomics, SCM can reveal rare metabolic cell states, spatially restricted metabolic niches,…
  pubmed Du J, Tao H, Zhang Y, Wu M 等 2026 Aug 26 置信度 0.82
• A Digital Stackable Guide Protocol for FP1 Full-Arch Esthetic Reconstruction With Monolithic Zirconia.
  To describe a fully digital and stackable surgical guide workflow for full-arch rehabilitation in a patient with advanced periodontitis, aiming to restore esthetics, function, and biological stability with a monolithic zirconia prosthesis.
  pubmed Maiza L, Barreiros P 2026 Aug 26 置信度 0.82
• Advances in the development and delivery of nucleic acid-based therapeutics.
  Recent advancements in experimental and computational methods along with growing gene sequencing libraries have enabled rapid development of nucleic acid-based therapeutic design for a wide variety of diseases. New drugs, delivery tools and methods have enable…
  pubmed Kurczewski E, Mansurov A, Sachar C, Guler MO 2026 Aug 26 置信度 0.82
• PySimi: a unified framework for similarity measure evaluation in spectral clustering with applications to omics data.
  High-throughput omics technologies generate increasingly large and complex datasets, creating a growing demand for clustering methods capable of identifying meaningful biological patterns. Spectral clustering is widely used for analyzing high-dimensional omics…
  pubmed Shi T, Ye X, Zou Z, Xi W 等 2026 置信度 0.82
• Deep Generative Model of Macrophage Immune Response for Hepato-intestinal Tumor Therapy Optimization.
  Digestive tract cancers, including hepatobiliary and gastrointestinal malignancies, remain a major oncological burden globally. Immunotherapy efficacy rates are low, with only 15% to 30% of patients experiencing responses following treatment. Tumor-associated …
  pubmed Zhou L, Tan Y, Lv W, Lin K 等 2026 置信度 0.82
• HELP-TCR: Harmonized Explainable Language Processing Toolkit for T Cell Antigen Receptor Repertoires.
  Functional characterization of T cell antigen receptor (TCR) repertoires is critical for understanding adaptive immune responses across diverse contexts, including infectious diseases, cancer, autoimmune conditions, and allergic disorders. Detailed analysis of…
  pubmed Kalesnik Y, Krawczyk D, Pietrzak M, Seweryn M 2026 置信度 0.82
• Dual Cross-Attention Network for Hierarchical Feature Fusion in Protein-Protein Interaction Prediction.
  Characterizing protein-protein interactions (PPIs) is essential for deciphering core biological processes, including signal transduction, metabolic pathway regulation, immune recognition, and cell cycle control. However, experimental PPI determination remains …
  pubmed Lu S, Li Y, Tian Z, Nan X 等 2026 置信度 0.82
• Advancements in Tactile-Free Medical Imaging
  ABSTRACT: During surgical procedures, it is important that the personnel (surgeon, residents, or assistants) interact with the patient avoiding any physical contact with equipment and materials that might have not been appropriately sterilized. This is done in…
  datacite Eva Maria Rodriguez-Reyes, Liam Alexander Sanchez-Gonzalez 2022 置信度 0.66 Functional MaterialsAdvanced PhysicsMaterials ScienceOpen Access
• The Universal Luxurian
  [ Introduction: The Universal Honeycomb Aether Theory ] "Modern science has finally begun to understand that the essence of the universe is 'information.' As the concept of 'It from bit' suggests, a computational structure exists behind our reality. However, t…
  datacite A=A' (Independent Researcher) 2026 置信度 0.66
• Benchmarking Bio-image Analysis Workflows on High Performance Computing and Edge Computing Platforms
  The developments in microscopy have enabled biologists to acquire high-resolution multimodal images of biological entities. This high-quality data can be in the order of Gigabytes or Terabytes in size. Hence, it is becoming increasingly common to see microscop…
  datacite Kulkarni, Somashekhar Hanumant 2024 置信度 0.66 bio-image analysisdeep learningmachine learningworkflowsbenchmarking
• Benchmarking Bio-image Analysis Workflows on High Performance Computing and Edge Computing Platforms
  The developments in microscopy have enabled biologists to acquire high-resolution multimodal images of biological entities. This high-quality data can be in the order of Gigabytes or Terabytes in size. Hence, it is becoming increasingly common to see microscop…
  datacite Kulkarni, Somashekhar Hanumant 2024 置信度 0.66 bio-image analysisdeep learningmachine learningworkflowsbenchmarking
• The Universal Aperture Transport System Topological Architecture, Hexadecimal Space, and the Computational Inversion of Matter
  The Universal Aperture Transport System Topological Architecture, Hexadecimal Space, and the Computational Inversion of Matter Driven by Dean A. Kulik September 2026 1. The Compiling of Reality and the Table of Precedent In the prevailing paradigms of theoreti…
  datacite kulik, dean 2026 置信度 0.66
• The Universal Aperture Transport System Topological Architecture, Hexadecimal Space, and the Computational Inversion of Matter
  The Universal Aperture Transport System Topological Architecture, Hexadecimal Space, and the Computational Inversion of Matter Driven by Dean A. Kulik September 2026 1. The Compiling of Reality and the Table of Precedent In the prevailing paradigms of theoreti…
  datacite kulik, dean 2026 置信度 0.66