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• Perspectives for self-driving labs in synthetic biology
  Self-driving labs (SDLs) combine fully automated experiments with artificial intelligence (AI) that decides the next set of experiments. Taken to their ultimate expression, SDLs could usher a new paradigm of scientific research, where the world is probed, inte…
  arxiv Hector Garcia Martin, Tijana Radivojevic, Jeremy Zucker, Kristofer Bouchard 等 2022-10-14T16:58:27Z 置信度 0.78 q-bio.OT
• A systems biology approach to COVID-19 progression in a population
  A number of models in mathematical epidemiology have been developed to account for control measures such as vaccination or quarantine. However, COVID-19 has brought unprecedented social distancing measures, with a challenge on how to include these in a manner …
  arxiv Magdalena Djordjevic, Andjela Rodic, Igor Salom, Dusan Zigic 等 2020-05-19T17:57:41Z 置信度 0.78 q-bio.PEphysics.soc-ph
• New Approaches in Synthetic Biology: Abiotic Organelles and Artificial Cells Powered and Controlled by Light
  One of the major goals of nanobionics and bottom-up synthetic biology is the development of artificial cell organelles for the creation of cell-like structures operating similar to biological systems with a minimalistic set of building blocks. In the present c…
  arxiv Günther Knör 2019-11-15T15:07:27Z 置信度 0.78 q-bio.SCq-bio.BMq-bio.MNq-bio.TO
• Biology and Physics
  This article frames the relation between biology and physics by characterizing the former as a subdiscipline rather than a special case of the latter. To do this, we posit biological physics as the science of living matter in contrast to classic biophysics, th…
  arxiv Stuart A. Newman, Sahotra Sarkar 2026-03-11T19:00:05Z 置信度 0.78 physics.bio-phcond-mat.softq-bio.TO
• Silicon is the next frontier in plant synthetic biology
  Silicon has striking similarity with carbon and is found in plant cells. However, there is no specific role that has been assigned to silicon in the life cycle of plants. The amount of silicon in plant cells is species specific and can reach levels comparable …
  arxiv Aniruddha Acharya, Kaitlin Hopkins, Tatum Simms 2025-03-13T02:33:29Z 置信度 0.78 q-bio.BM
• High-Throughput Biologically Optimized Search Engineering Approach to Synthetic Biology
  Synthetic Biology is the new engineering-based approach to biology that includes applications of designing complex biological devices. At present, it is not yet clear what will emerge as the defining principles of Synthetic Biology. One proposed approach is to…
  arxiv A. X. C. N. Valente, Stephen S. Fong 2011-03-28T21:17:25Z 置信度 0.78 q-bio.QM
• ART: A machine learning Automated Recommendation Tool for synthetic biology
  Biology has changed radically in the last two decades, transitioning from a descriptive science into a design science. Synthetic biology allows us to bioengineer cells to synthesize novel valuable molecules such as renewable biofuels or anticancer drugs. Howev…
  arxiv Tijana Radivojević, Zak Costello, Kenneth Workman, Hector Garcia Martin 2019-11-25T17:46:36Z 置信度 0.78 q-bio.QMstat.ML
• BioPreDyn-bench: benchmark problems for kinetic modelling in systems biology
  Dynamic modelling is one of the cornerstones of systems biology. Many research efforts are currently being invested in the development and exploitation of large-scale kinetic models. The associated problems of parameter estimation (model calibration) and optim…
  arxiv Alejandro F Villaverde, David Henriques, Kieran Smallbone, Sophia Bongard 等 2014-07-22T13:31:05Z 置信度 0.78 q-bio.QMcs.CEq-bio.MN
• For principled model fitting in mathematical biology
  The mathematical models used to capture features of complex, biological systems are typically non-linear, meaning that there are no generally valid simple relationships between their outputs and the data that might be used to validate them. This invalidates th…
  arxiv Thomas House 2014-04-21T20:32:28Z 置信度 0.78 q-bio.QM
• Stochastic Testing Simulator for Integrated Circuits and MEMS: Hierarchical and Sparse Techniques
  Process variations are a major concern in today's chip design since they can significantly degrade chip performance. To predict such degradation, existing circuit and MEMS simulators rely on Monte Carlo algorithms, which are typically too slow. Therefore, nove…
  arxiv Zheng Zhang, Xiu Yang, Giovanni Marucci, Paolo Maffezzoni 等 2014-09-16T22:15:47Z 置信度 0.78 cs.CE
• Computer-aided whole-cell design: taking a holistic approach by integrating synthetic with systems biology
  Computer-aided design for synthetic biology promises to accelerate the rational and robust engineering of biological systems; it requires both detailed and quantitative mathematical and experimental models of the processes to (re)design, and software and tools…
  arxiv Lucia Marucci, Matteo Barberis, Jonathan Karr, Oliver Ray 等 2020-06-04T09:19:52Z 置信度 0.78 q-bio.QMq-bio.MN
• Cancer systems biology in the genome sequencing era: Part 1, dissecting and modeling of tumor clones and their networks
  Recent tumor genome sequencing confirmed that one tumor often consists of multiple cell subpopulations (clones) which bear different, but related, genetic profiles such as mutation and copy number variation profiles. Thus far, one tumor has been viewed as a wh…
  arxiv Edwin Wang, Jinfeng Zou, Naif Zaman, Lenore K. Beitel 等 2014-09-06T02:38:11Z 置信度 0.78 q-bio.MN
• Biologic: Gene circuits and feedback in an introductory physics sequence for biology and premedical students
  Two synthetic gene circuits -- the genetic toggle switch and the repressilator -- are analyzed quantitatively and discussed in the context of an educational module on gene circuits and feedback that constitutes the final topic of a year-long introductory physi…
  arxiv S. B. Cahn, S. G. J. Mochrie 2013-07-11T14:32:40Z 置信度 0.78 physics.ed-phq-bio.MN
• A synthetic biology approach for the design of genetic algorithms with bacterial agents
  Bacteria have been a source of inspiration for the design of evolutionary algorithms. At the beginning of the 20th century synthetic biology was born, a discipline whose goal is the design of biological systems that do not exist in nature, for example, program…
  arxiv A. Gargantilla Becerra, M. Gutiérrez, R. Lahoz-Beltra 2021-01-19T09:59:33Z 置信度 0.78 cs.NEcs.MA
• Cancer systems biology in the genome sequencing era: Part 2, evolutionary dynamics of tumor clonal networks and drug resistance
  A tumor often consists of multiple cell subpopulations (clones). Current chemo-treatments often target one clone of a tumor. Although the drug kills that clone, other clones overtake it and the tumor reoccurs. Genome sequencing and computational analysis allow…
  arxiv Edwin Wang, Jinfeng Zou, Naif Zaman, Lenore K. Beitel 等 2014-09-06T02:48:08Z 置信度 0.78 q-bio.MN
• Inverse problems for coupled nonlocal nonlinear systems arising in mathematical biology
  In this paper, we propose and study several inverse problems of determining unknown parameters in nonlocal nonlinear coupled PDE systems, including the potentials, nonlinear interaction functions and time-fractional orders. In these coupled systems, we enforce…
  arxiv Ming-Hui Ding, Hongyu Liu, Catharine W. K. Lo 2024-07-22T15:20:04Z 置信度 0.78 math.APq-bio.PE
• From Prediction to Simulation: AlphaFold 3 as a Differentiable Framework for Structural Biology
  AlphaFold 3 represents a transformative advancement in computational biology, enhancing protein structure prediction through novel multi-scale transformer architectures, biologically informed cross-attention mechanisms, and geometry-aware optimization strategi…
  arxiv Alireza Abbaszadeh, Armita Shahlaee 2025-08-25T19:49:28Z 置信度 0.78 q-bio.BMcs.LG
• A comprehensive review of resistome profiles in ocular pathogens: Insights into Pseudomonas aeruginosa and emerging resistance trends.
  Eye infections are a significant area of microbial adaptation and therapeutic challenge, as antibiotic resistance threatens vision. In the last ten years, our knowledge of the ocular resistome has expanded through genomics and molecular epidemiology. An analys…
  europepmc 2026 置信度 0.80
• FASTERCC: Accelerating Flux Consistency Testing and Context-Specific Reconstruction for Large-Scale Metabolic Network Models
  The increase in size of metabolic network models especially with the advent of single-cell data calls for scalable reconstruction and analysis tools. Such models, often used for drug discovery and the analysis of microbial communities rely on consistency testi…
  europepmc 2026 置信度 0.80
• Thermal analysis of bioconvection flow of CNTs/water based hybrid nanofluid with gyrotactic microbes using artificial neural network.
  This study uses the Levenberg-Marquardt strategy with feed forward neural networks (LMS-FNN) to inspect the Soret-Dufour effect on radiative hybrid nanofluid flow across a Riga plate with gyrotactic microorganisms. The suggested model, which investigates the t…
  europepmc 2026 置信度 0.80
• A single-cell blueprint for cellular diversity in the Green Lineage.
  The Green Lineage (Viridiplantae) represents one of the most successful evolutionary radiations on Earth, with remarkable morphological diversity from unicellular algae to complex multicellular land plants. Recent advances in single-cell genomics have transfor…
  europepmc 2026 置信度 0.80
• DiazoTIME: a metabolically-resolved reference database of nitrogen-fixing microbial genomes.
  Microbial nitrogen fixation (diazotrophy) is a critical ecological process. We curated DiazoTIME (Diazotroph Taxonomic Identity and MEtabolism), a comprehensive database of diazotroph genomes including taxonomic annotation and metabolic prediction. DiazoTIME i…
  europepmc 2025 置信度 0.80
• Complete genome sequence of <i>Pseudomonas spelaei</i> strain PML3(3), an effective mineral-weathering bacterial strain isolated from the oak<i>-Scleroderma citrinum</i> ectomycorrhizosphere.
  We present the complete genome sequence of Pseudomonas spelaei strain PML3(3), isolated from the oak -Scleroderma citrinum ectomycorrhizosphere in acidic forest soil at the ecosystem research site of Breuil-Chenue, France. This genome encodes functions related…
  europepmc 2026 置信度 0.80
• Mushroom biotech startups help address global challenges.
  The mushroom innovation ecosystem highlights significant advances in mycology, biotechnology, and biofabrication, as well as the role of startups in translating these breakthroughs into products. By tracing these translational pathways, this Perspective aims t…
  europepmc 2026 置信度 0.80
• Comparative evaluation of deep learning architectures for microbial colony classification in microbiological imaging.
  Background Visual interpretation of microbial colonies on agar plates is an essential task for experienced microbiologists. In high-throughput workflows and large-scale screening, automated image-based methods can provide decision-support capabilities in stand…
  europepmc 2026 置信度 0.80
• Self-grown mycelium in confined geometries as nanofluidic devices.
  Precise control of ion and molecular transport at the nanoscale underpins next-generation nanofluidic technologies. However, current approaches such as top-down fabrication and bottom-up assembly remain constrained by cost, scalability, or limited programmabil…
  europepmc 2026 置信度 0.80
• Biosurfactant-Producing Bacteria Isolated from a Microbial Consortium Previously Subjected to Adaptive Laboratory Evolution in Oily Sludge.
  Microbial bioprospecting in contaminated environments is a promising strategy for identifying biosurfactant-producing bacteria; however, translating environmentally adapted strains into predictable cultivation processes remains challenging. In this study, a mi…
  europepmc 2026 置信度 0.80
• Zone of inhibition prediction in silver nanoparticle antimicrobial activity via physics-guided liquid state machine.
  Silver nanoparticles are widely applied in medicine, packaging, and environmental remediation because of their potent antimicrobial properties. Nevertheless, predictive modeling of their zone of inhibition (ZOI) remains a longstanding challenge due to limited …
  europepmc 2026 置信度 0.80
• The Gene Taxonomic Prevalence (GeTPrev) Pipeline for Scalable Gene Prevalence Estimation Across Bacterial Taxa.
  The National Center for Biotechnology Information (NCBI) stores over 1 million bacterial genome sequences, with no tools capable of estimating the prevalence of specific nucleotide sequences within or across taxa. To address this gap, we developed the Gene Tax…
  europepmc 2026 置信度 0.80
• A Systematic Benchmark of Antibiotic Resistance Gene Detection Tools for Shotgun Metagenomic Datasets
  1. Accurate detection of antimicrobial resistance genes (ARGs) from metagenomic data is essential for understanding resistance dissemination within microbial communities, yet tool performance remains influenced by sequencing coverage, community complexity, and…
  europepmc 2026 置信度 0.80
• Navigating luminal heterogeneity: etiology-based proteogenomic subtyping for targeted treatment strategies in breast cancer.
  Background Luminal breast cancer is rising rapidly among East Asian women, particularly younger patients, with variable clinical outcome, yet current risk-stratification models inadequately predict early recurrence of under-studied young-onset cases. We hypoth…
  europepmc 2026 置信度 0.80
• Modeling diet-gut microbiome interactions and prebiotic responses in Thai adults.
  The impact of diet on gut microbial metabolism is essential for advancing microbiome-based health interventions. This study introduces a novel systems biology pipeline that integrates genome-scale metabolic models (GSMMs) with Thai dietary intake data to simul…
  europepmc 2026 置信度 0.80
• Recent advances in computational antimicrobial peptide discovery through big data, modeling, and artificial intelligence and their interplay in ushering the next golden era of drug development.
  The accelerating antimicrobial resistance (AMR) crisis continues to render more and more conventional antibiotics ineffective. Antimicrobial peptides (AMPs) are promising alternatives to traditional antibiotics due to their broad-spectrum activity, diverse mec…
  europepmc 2026 置信度 0.80
• Biofilm removal in hospital sink drains drives unintended surges in antibiotic resistance.
  The prevalence and proliferation of antimicrobial-resistant bacteria is considered one of the critical issues of our time. Wastewater is a habitat for complex microbial communities where bacteria share antimicrobial-resistance genes through horizontal gene tra…
  europepmc 2026 置信度 0.80
• Gene-level gut microbiome signatures as predictive biomarkers for response to immune checkpoint inhibitors across multiple cancer types.
  Targeting programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) with immune checkpoint inhibitors (ICIs) has improved survival across multiple cancer types, but the variability in patient response highlights the need f…
  europepmc 2026 置信度 0.80
• Current Status of Smart Technology Applications and Food Safety Implications in Precision Millet Fermentation: A Critical Review.
  Millet fermentation has gained significant attention due to its numerous health benefits, owing to its higher dietary fiber and gluten-free properties, making it suitable for celiacs, individuals with diabetes, and higher heart risk due to its low glycemic ind…
  europepmc 2026 置信度 0.80
• OmniCorr: an R-package for visualizing putative host-microbiome interactions using multi-omics data.
  Holo-omics leverages omics datasets to explore the interactions between hosts and their associated microbiomes. Although the generation of omics data from matching host and microbiome samples is steadily increasing, there remains a scarcity of computational to…
  europepmc 2026 置信度 0.80
• The biosynthetic gene cluster landscape of the oral microbiome across health and dental caries.
  Specialized metabolites encoded by biosynthetic gene clusters (BGCs) in the oral microbiome remain largely unexplored in the context of oral health and disease. Previous genome-centric surveys have identified hundreds of uncharacterized BGCs in the oral cavity…
  europepmc 2026 置信度 0.80
• Airway microbiome–host transcriptome networks link microbial dysbiosis to survival outcomes and therapeutic opportunities in severe COVID-19
  SUMMARY The lower respiratory tract microbiome may critically influence outcomes in severe COVID-19, yet remains understudied. We analyzed bronchoalveolar lavage fluid from 86 severe patients requiring mechanical ventilation, stratified into two groups. We ide…
  europepmc 2025 置信度 0.80
• Generative AI-driven enzyme engineering unlocks sustainable valorization of broccoli waste into sulforaphane.
  Current production of sulforaphane (SFN), a health-promoting isothiocyanate, relies mainly on energy-intensive plant extraction or chemical synthesis, limiting sustainable large-scale manufacture. Here, a waste-to-value framework integrating generative artific…
  europepmc 2026 置信度 0.80
• Lactobacillus Is Associated With Disease in Pulmonary Arterial Hypertension: A Prospective Cohort Study.
  Background Gut dysbiosis and gut-derived metabolites have been linked to pulmonary arterial hypertension. However, associations between specific microbes, and corresponding metabolites, with pulmonary arterial hypertension disease severity is limited. Methods …
  europepmc 2026 置信度 0.80
• Oat-Rich Low-Gluten Diet Modulates Plasma Short-Chain Fatty Acids without Significant Changes in Fecal Microbiome or Inflammatory Markers-A Randomized Clinical Trial in People with Cardiometabolic Risk.
  Background Increasingly popular low-gluten diets (LGDs) are generally low in fiber; however, it is possible to improve the LGD by using oat-based products. Objectives To investigate the changes in fecal microbiome, fasting plasma short-chain fatty acids (SCFAs…
  europepmc 2026 置信度 0.80
• Characterization and targeting of deleterious mutations in Carbapenemase-producing Klebsiella pneumoniae: insights from variant calling, Computer-aided drug design, and DFT analysis.
  The emergence of Carbapenemase-producing Klebsiella pneumoniae (CP-KP) strains is becoming a significant global concern. Rising resistance rates in these strains significantly impact available treatment options. Therefore, this present research aims to identif…
  europepmc 2026 置信度 0.80
• Multidimensional scaling informed by F-statistic: Visualizing grouped microbiome data with inference.
  Multidimensional scaling (MDS) is a widely used dimensionality reduction technique in microbial ecology data analysis that captures the multivariate structure of the data while preserving pairwise distances between samples. While improvements in MDS have enhan…
  europepmc 2026 置信度 0.80
• Large-scale profiling of blood microbial signatures in patients with Parkinson's disease and its association with disease progression: a cross-sectional study.
  Background Emerging evidence supports the presence of microbial signatures in the blood, yet their clinical relevance remains poorly understood. In this study, we profiled blood microbial signatures in patients with Parkinson's disease (PD) and investigated th…
  europepmc 2026 置信度 0.80
• Microbial bioleaching of rare earth elements from phosphate minerals: a biotechnology-driven systematic review of mechanisms, bioprocess determinants, and opportunities for sustainable recovery.
  Background Rising demand for rare earth elements (REEs) and the severe environmental impact of conventional extraction from phosphate minerals (monazite, apatite) have intensified the search for green alternatives. Microbial bioleaching offers a low-energy, lo…
  europepmc 2026 置信度 0.80
• Antibacterial Activity of α-Sulfamidophosphonate Derivatives and Their In Silico Assessment as Dihydropteroate Synthase Binders.
  In this study, we report the first antibacterial evaluation of a focused library of 12 previously synthesized α-sulfamidophosphonate derivatives (4a-4l) against a panel of nine Gram-positive and Gram-negative strains, including ESBL- and carbapenemase-pr…
  pubmed Ghodbane R, Mairi A, K'tir H, Touati A 等 2026 Aug 置信度 0.82
• A metabolite morphogen coordinates multicellular development in Bacillus subtilis.
  The transition from unicellular to multicellular growth requires diversification of cellular functions within genetically identical populations. In Bacillus subtilis , biofilm formation is historically viewed as a developmental precursor to sporulation along a…
  pubmed Updegrove TB, Pande V, She F, Gilmore MC 等 2026 Aug 7 置信度 0.82
• A mobile based antimicrobial susceptibility testing device - prototype development and validation.
  Background and objectives Antimicrobial resistance is a major concern due to multidrug-resistant pathogens. Advances in smartphone technology provide opportunity to digitise antimicrobial susceptibility testing (AST). This study aimed to develop and validate a…
  pubmed Aravindh A, Gupta A, Sen M, Das A 等 2026 Aug 置信度 0.82
• Harnessing the gut microbiome to combat tuberculosis: a technological and clinical review.
  Tuberculosis (TB), especially multidrug-resistant and extensively drug-resistant strains, remains a severe global health threat. Advances in high-throughput sequencing, omics technologies and artificial intelligence have revealed the critical involvement of th…
  pubmed Sun W, Xiao M, Ali SL, Jin C 等 2026 置信度 0.82
• Selective conservation of symbiont cell-surface glycans across generations in a vertically transmitting coral.
  Coral resilience under climate change depends on the stability of coral-Symbiodiniaceae symbioses. Vertically transmitting corals inherit symbionts directly from parental colonies, yet the extent to which symbiont cellular traits are conserved across host life…
  pubmed Tortorelli G, Fisher NL, Varela AC, Rosset SL 等 2026 Aug 5 置信度 0.82
• CRISPR/Cas system as a novel therapeutic strategy to combat multi-drug-resistant bacteria.
  Antimicrobial resistance (AMR) has diminished the effectiveness of present antibiotics, posing a huge threat to global community health and economic stability. This study investigates the CRISPR-Cas framework's potential as a cutting-edge tactic to fight antim…
  pubmed Zubair A, Hemal MAKP, Ahmed A, Ahmad F 等 2026 Aug 5 置信度 0.82
• Mutation-driven alterations in the AcrB efflux pump modulate antibiotic resistance in Klebsiella pneumoniae.
  To investigate the global prevalence of the acrB efflux transporter among antibiotic resistance genes (ARGs) in Klebsiella pneumoniae and to determine how mutations within AcrB drug-binding pockets influence structural stability and antibiotic interactions.
  pubmed Dinata R, Baindara P, Chakraborty S, Mondal S 等 2026 Aug 4 置信度 0.82
• Metagenomic next-generation sequencing: new horizons in microbiology.
  The COVID-19 pandemic has exposed vulnerabilities in global health systems while accelerating the adoption of metagenomic next-generation sequencing (mNGS) as a transformative tool for culture-independent, unbiased microbial detection. In clinical diagnostics,…
  pubmed Guo N, Chen S, Guo L, Qiu X 等 2026 置信度 0.82
• High-resolution promoter interaction analysis implicates genes involved in activation of type 3 innate lymphoid cells in immune disease risk.
  Innate lymphoid cells (ILCs) are rare tissue-resident lymphocytes that functionally mirror cells of CD4 + T helper lineage but lack antigen receptors. Type 3 ILCs (ILC3s) are enriched at barrier sites, regulating inflammation and promoting tissue integrity. He…
  pubmed Malysheva V, Ray-Jones H, Lakes N, Brown RA 等 2026 Aug 4 置信度 0.82
• Experimental and computational analysis of LUCA lipase stability in methanol for biodiesel production from waste cooking oil.
  Enzymatic biodiesel production using lipases offers a sustainable alternative to chemical catalysis; however, challenges such as thermal instability and methanol-induced deactivation can limit industrial application. This study investigates the catalytic effic…
  pubmed Saad AHM, Kamarudin NHA, Leow ATC, Mohamed MS 等 2026 Aug 4 置信度 0.82
• Clinical, molecular, and in vitro evidence of artemisinin partial resistance in Ethiopian Plasmodium falciparum: a prospective, multisite, surveillance study.
  Artemisinin partial resistance (ART-R) has been confirmed in four sub-Saharan African countries since 2020, but evidence from Ethiopia is limited to molecular surveys without phenotypic confirmation. We aimed to determine whether ART-R met WHO criteria in Ethi…
  pubmed Chala B, Platon L, Tibiri YNG, Strubel PE 等 2026 Aug 4 置信度 0.82
• Ultrasound/electrostatic field combined with ε-polylysine for improving the quality of ready-to-eat pork jelly and freshness classification based on convolutional neural network.
  This study investigated the effects of ultrasound (US, 300 W, 20 kHz, 20 min) and electrostatic field (EF, 3.5 kV/cm, 60 min) combined with ε-polylysine (PL, 0.5%, w/w) on the quality of ready-to-eat pork jelly (Shuijingyaorou, S…
  pubmed Guo Q, Zhang M, Bhandari B, Yu Q 等 2026 Jul 31 置信度 0.82
• Editorial: Artificial intelligence in microbial and microscopic analysis.
  pubmed Zhang J, Guo J, Liu Q, Liu F 2026 置信度 0.82
• Pongamia pinnata (L.) Pierre leaf extract: in vitro, in vivo, and in silico approaches to combat the waterborne bacterial pathogens associated with diarrheal conditions.
  Pongamia pinnata (L.) Pierre, a medicinal plant traditionally used in Indian ethnomedicine, was evaluated for its antidiarrheal, antibacterial, and antioxidant properties through a combination of in vitro , in vivo , and in silico approaches. This study aims t…
  pubmed Kumar A, Laldingliani TBC, Kumar R, Thangjam NM 等 2026 置信度 0.82
• Microbial Diversity Estimation and Hill Number Calculation Using the Hierarchical Pitman-Yor Process.
  The human microbiome comprises the microorganisms that inhabit the various locales of the human body and plays a vital role in human health. The composition of a microbial population is often quantified through measures of species diversity, which summarize th…
  pubmed McGregor K, Parsons T, Simons E, Scott J 等 2026 Aug 置信度 0.82
• Prioritization of deleterious mutations informs genomic prediction and increases the rate of gain in common bean (Phaseolus vulgaris L.), a simulation study.
  Predicted deleterious mutations (SNPs) have different distributions of effects compared to random SNPs based on population composition. Variant prioritization of markers based on deleterious scores can improve the prediction of yield. Favoring mating schemes b…
  pubmed Cordoba-Novoa H, Hoyos-Villegas V 2026 Aug 3 置信度 0.82
• Rapid determination of potential mycotoxin-producing fungi contamination in post-harvest blueberries based on near infra-red spectroscopy and enhanced prototypical network.
  Blueberries are susceptible to fungal infection that may lead to mycotoxin contamination. Accurate identification of mycotoxin-producing fungi in blueberries is critical, as processed products derived from mould-contaminated fruits pose significant health risk…
  pubmed Zhu L, Xia W, Xie L, Wang X 等 2026 Aug 3 置信度 0.82
• Green Synthesis of Silver Nanoparticles From Macaranga tanarius (L.) Mull. Arg. Leaf Extract With Enhanced Antibacterial, Antioxidant, and Tyrosinase Inhibitory Activities.
  Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by microbial imbalance, particularly the overgrowth of Staphylococcus aureus . This study reports the green synthesis of silver nanoparticles (AgNPs) using Macaranga tanarius extract …
  pubmed Yeh HY, Chand M, Barawi SS, Ho HC 等 2026 置信度 0.82
• MeioBIOME: A snakemake workflow for the parallel analysis of meiofaunal genomes and host-associated bacteria/archaea.
  Microbes closely interact with every living organism, including meiofauna (i.e., microbial eukaryotes 38 μm - 1 mm in length), and influence the development, life cycle, and evolution of diverse metazoans. Together, meiofauna and their microbiomes, colle…
  pubmed De Santiago A, Bik H 2026 Jul 24 置信度 0.82
• High-precision binary trait association on phylogenetic trees.
  Traditional methods for identifying associations between genomic features and traits, or between pairs of genomic traits, struggle when applied to bacterial genomes. While several microbial genome-wide association study (mGWAS) methods have been developed to a…
  pubmed Balogun IO, Mancuso CP, Lieberman TD 2026 Jul 置信度 0.82
• Applying the design-build-test-learn framework to precision fermentation for sustainable food ingredients.
  Precision fermentation enables the sustainable synthesis of value-added products by engineering microorganisms into specialized cell factories. Unlike traditional fermentation, food-grade precision fermentation operates within a highly regulated framework rela…
  pubmed Shin J 2026 Aug 置信度 0.82
• Impact of Lipophilicity-Tuning on the Antimicrobial Activity of a Series of β-Face-Expanding Bile Acid Derivatives.
  The increasing prevalence of antimicrobial resistance has stimulated the search for new molecular scaffolds with improved efficacy and selectivity. In this study, five bile acid-derived aminosteroids (AC series) and their corresponding biphenyl-functionalized …
  pubmed Abarca AM, Rivera-Montero L, Barrantes K, Soto-Tellini VH 等 2026 置信度 0.82
• Antimicrobial peptides in anti-infective and immunomodulatory applications: Mechanisms, challenges, and emerging computational design.
  Antimicrobial Peptides (AMPs) evolutionarily conserved effectors of innate immunity, have emerged as multifunctional agents with broad-spectrum antimicrobial activity, immunomodulatory capabilities, and potential applicability in cancer therapy. Despite their …
  pubmed Wang YL, Yang YQ, Zhou YY, Duan ZL 等 2026 Jul 18 置信度 0.82
• Exploring halophilic microorganisms for novel antimicrobial discovery: molecular mechanisms and computational approaches.
  The rapid rise in antibiotic resistance, which causes more than 700,000 deaths worldwide each year, has intensified the search for alternative antimicrobial sources to combat multidrug-resistant (MDR) pathogens. Halophilic microorganisms inhabiting hypersaline…
  pubmed Bhowmick P, Kumar P, Panjabi S, Dhiman S 2026 Jul 31 置信度 0.82
• Antimicrobial peptides selected through deep learning can be utilized for the control of Pseudomonas fluorescens in milk.
  Contamination of milk by psychrotrophic Pseudomonas species represents a primary cause of dairy product spoilage. Antimicrobial peptides (AMPs) present unique advantages for food applications due to their favorable safety profiles, low toxicity, and limited po…
  pubmed Wang Y, Li S, Wang Z, Wu Y 等 2026 Jul 28 置信度 0.82
• Bioassay-guided isolation of antioxidant, antibacterial, and antidiabetic compounds from Aleuritopteris bicolor of Nepal: In vitro/in silico study.
  Aleuritopteris bicolor, a fern species known locally as "Raani Sinkaa" in Nepal, has traditionally been used to treat wounds, diarrhea, dysentery, and gastritis. Despite its widespread use, scientific data on its bioactive compounds and bioactivities remain li…
  pubmed Bhandari R, Sapkota S, Bishwakarma PK, Sharma SK 等 2026 置信度 0.82
• Molecular insights, resistance profiling, and in silico structural modeling of extended-spectrum beta-lactamase-producing E. coli in camels.
  The global surge of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (E. coli) imposes an unnoticed but significant threat, fueling antimicrobial resistance (AMR). Being a neglected host, camels suffering from subclinical mastitis (SCM) cause…
  pubmed Safdar M, Ijaz M, Ahmed A, Javed MU 等 2026 Jul 30 置信度 0.82
• Integrative Analysis Reveals Interactions Between Gut Microbiota-Derived Metabolites and the Brain in Parkinson's Disease.
  Parkinson's disease (PD) is a neurodegenerative disorder increasingly associated with gut microbiota alterations, yet the mechanisms by which microbial metabolites influence PD remain unclear. Here, we applied an integrative computational and experimental stra…
  pubmed Shao Y, Han J, Hu S 2026 Jul 30 置信度 0.82
• Evaluation of Bread Wheat (Triticum aestivum L.) Advanced Lines and Commercial Varieties to the Response of Septoria tritici blotch in Northwestern Ethiopia.
  Septoria tritici blotch (STB), caused by Zymoseptoria tritici is among the most damaging foliar diseases of wheat, with yield losses reaching up to 82% under favorable conditions. To identify resistant sources, one hundred sixty bread wheat genotypes were scre…
  pubmed Fenta W, Sintayehu A, Mengist Y, Alemu T 等 2026 Jul 30 置信度 0.82
• Shotgun metagenomic analysis reveals taxonomic and functional alterations in the gut microbiome across prodromal and symptomatic Lewy body disease.
  Lewy body disease (LBD) is a progressive neurodegenerative a-synucleinopathy, whereas isolated REM sleep behavior disorder (iRBD) is recognized as a prodromal stage of LBD. Although growing evidence implicates the gut-brain axis in neurodegeneration, the taxon…
  pubmed Zhao X, McCarter SJ, Gupta VK, Grant KM 等 2026 置信度 0.82
• Active components of Patrinia scabiosifolia and mechanisms of action against methicillin-resistant Staphylococcus Epidermidis.
  Staphylococcus epidermidis is a significant cause of hospital bloodstream infections, often transmitted through medical devices. Methicillin-resistant Staphylococcus epidermidis (MRSE) exhibits multidrug resistance, challenging clinical treatment. Current opti…
  pubmed Luo Q, Cui W, Ni M, Yang Y 等 2026 置信度 0.82
• Design of a cyclic peptide targeting intracellular Staphylococcus aureus.
  Methicillin-resistant Staphylococcus aureus (MRSA) remains a major clinical challenge, particularly intracellular MRSA infections are difficult to treat because antimicrobial agents must combine stability, host-cell access and bacterial target engagement. Cycl…
  pubmed Mourenza Á, Llano-Verdeja J, Castañera P, Krishnan R 等 2026 Jul 29 置信度 0.82
• Promoter-associated RNA polymerase III shapes RNA polymerase II-dependent inflammatory gene expression during viral infection.
  Cells must be primed to rapidly induce inflammatory gene expression upon infection while also tuning the level of induction to avoid immunopathology. Here, we identify RNA polymerase III (Pol III), best known for transcribing noncoding RNAs, as a dual-function…
  pubmed Lari A, Shah SB, Batarseh S, Nagorsen M 等 2026 Jul 15 置信度 0.82
• Cooperation, privatization and cheating in microbial exoenzyme synthesis: theoretical analysis in view of biotechnological applications.
  This study presents a mathematical framework for investigating the dynamics of coexistence and competition among heterotrophic microbes across different time scales. Focusing on metabolic interactions, we examine how three strategies, public metabolizing, priv…
  pubmed Hassan T, Dwivedi S, Schuster S, Matuszyńska A 2026 Jul 29 置信度 0.82
• Unveiling active microbial processes in Earth's deepest seawater.
  Microorganisms dominate life in the hadal zone, yet extreme sampling difficulty and low biomass have precluded characterization of their in situ activities. Here, we analyze microbiome samples collected from hadal seawaters via in situ filtration during 12 hum…
  pubmed Zhang WJ, Hu A, Wu Z, Liu L 等 2026 Jul 28 置信度 0.82
• Assessing the proinflammatory potential of sterile fecal microbiome filtrate from ulcerative colitis patients using an intestine-on-chip platform and automated image analysis.
  Ulcerative colitis (UC) is characterized by disruptions of the gut microbiome and an exaggerated mucosal immune response in genetically susceptible individuals. Alterations in the composition of the intestinal metabolome associated with dysbiosis can trigger c…
  pubmed Schaal T, Akbarimoghaddam P, Wegner VD, Steube A 等 2026 Dec 31 置信度 0.82
• Blood transcriptome bridges orthogonal immunotypes and gut microbiome enterotypes in humans.
  Unveiling the systemic effects of disease and health requires a holistic approach that has mainly revolved around well-established, determinable molecular relationships such as the protein synthesis cascade and epigenetic mechanisms. In this study, we integrat…
  pubmed Affaticati F, Ha MK, Gehrmann T, De Boeck I 等 2026 Jul 27 置信度 0.82
• Paired comparison of tumor core and airway lumen (BALF) microbiomes in lung adenocarcinoma: deciphering specific Bacillus enrichment and immunomodulation.
  Lung adenocarcinoma (LUAD) is the leading cause of cancer mortality. While the lung microbiome influences tumorigenesis, the spatial heterogeneity between the airway reservoir (bronchoalveolar lavage fluid, BALF) and the actual intratumoral niche remains under…
  pubmed Yan L, Yang H, Feng H, Qi F 等 2026 置信度 0.82
• gNODE: gLV model-informed neural ordinary differential equations for modeling microbial community dynamics.
  The human gut microbiota is a highly complex ecological system closely linked to host health, yet the functional mechanisms underlying its dynamic behavior remain poorly understood. Accurate modeling of microbial community dynamics is essential for elucidating…
  pubmed Tan X, Xue F, Xie L, Wang T 2026 置信度 0.82
• Molecular characteristics and pathogenicity-associated phenotypes of methicillin-resistant Staphylococcus aureus sequence type 398 clinical isolates from a women and children's hospital in Southwest China.
  Methicillin-resistant Staphylococcus aureus (MRSA) sequence type 398 (ST398), initially recognized as a livestock-associated lineage, has been increasingly reported in human infections. However, the molecular characteristics, antimicrobial resistance profiles,…
  pubmed Liu L, Yan Z, Chen J, Fu Y 等 2026 置信度 0.82
• Calcium-induced PII oligomerization enhances physiological performance in the cyanobacterium Synechococcus elongatus PCC 7942.
  Calcium (Ca²⁺) functions as a universal signaling ion across biological systems, yet its role in cyanobacterial metabolic regulation remains underexplored. Here, we investigated the association between Ca²⁺ availability and physiologica…
  pubmed Gupta N, Bhattacharjee S, Srivastava A, Gupta S 等 2026 Jul 28 置信度 0.82
• Gram-Positive Bacteria and the Inverse Association between Farm Exposure and Childhood Asthma.
  The inverse association of farm exposure with asthma and atopic conditions has been attributed to the diversity of environmental bacteria and fungi, but the specific taxa and the underlying mechanisms remain elusive.
  pubmed Pagani G, Loss G, Pechlivanis S, Depner M 等 2026 Aug 置信度 0.82
• A Wireless Sensor Network for High Spatial and Temporal Resolution Soil Gas Emission Monitoring.
  Wide-scale, spatio-temporal quantification of soil CO 2 efflux is essential for understanding terrestrial carbon dynamics, predicting climate change, and evaluating the carbon balance in managed and natural ecosystems. Rising global temperatures, changing land…
  pubmed Biradavolu Y, Winanto HY, Shahid MO, Krishnaswamy B 等 2026 Jul 20 置信度 0.82
• Feasibility and Compliance of Stool Collection for Future Microbiome-Based Colorectal Cancer Screening: Preliminary Findings from a Prospective Multicenter FIT-Positive Cohort.
  Colorectal cancer (CRC) remains a major global health burden, and early detection through population-based screening programs significantly reduces both incidence and mortality. Although gut microbiome-based biomarkers have emerged as promising non-invasive to…
  pubmed Severino A, Rondinella D, Varca S, Schepis T 等 2026 Jul 17 置信度 0.82
• Small Regulatory RNAs in Prokaryotes: Key Features, Identification, Environmental Roles, and Applications.
  Small non-coding RNAs (sRNAs) are ubiquitous post-transcriptional regulators that enable rapid bacterial adaptation to fluctuating environments. Previous reviews have largely focused on sRNA mechanisms in model organisms. This review integrates computational p…
  pubmed Nawaz MA, Nawaz MZ, Haider SZ, Alghamdi HA 等 2026 Jul 16 置信度 0.82
• Community Characteristics and Performance of Phenanthrene-Degrading Microbial Consortia and Immobilized Composite Beads from Contaminated Sites.
  Although microbial remediation is a promising strategy for PAH pollution control, its field application remains a significant challenge. PAH-degrading microbial consortia were enriched from contaminated sites in Nanjing. High-throughput sequencing was applied …
  pubmed Chen L, Zhao Z, Xia L, Qin Z 等 2026 Jul 3 置信度 0.82
• Unveiling the Chemical Composition and Biological Activity of Extracts from the Antarctic Yeast Dioszegia sp. AL(105) and Bannozyma sp. AL(104).
  The extreme Antarctic environment offers unique living conditions. The organisms inhabiting Antarctica have a specific metabolism through which they overcome the challenges of large temperature amplitudes, long periods of light or darkness, and intense UV radi…
  pubmed Rusinova-Videva S, Zaharieva MM, Zheleva-Dimitrova D, Lozanova V 等 2026 Jul 16 置信度 0.82
• Integrated Experimental and Preliminary In Silico Study of Myrtenyl Dihydrocaffeate: Biocatalytic Synthesis Optimization, Antioxidant Evaluation, and Oxidative Stabilization of Rapeseed Oil.
  Dihydrocaffeic acid (DHCA) is a naturally occurring phenolic acid with recognized antioxidant and biological properties. However, its relatively high polarity limits its applicability in lipid-based systems. In this study, myrtenyl dihydrocaffeate was synthesi…
  pubmed Zieniuk B, Gielmuda J, Ononamadu CJ 2026 Jul 15 置信度 0.82
• In Silico Mutational Analysis of Two-Component System Genes Associated with Colistin Resistance in Clinical Pseudomonas aeruginosa Isolates from Peshawar.
  Pseudomonas aeruginosa is an opportunistic pathogen causing healthcare-associated infections. Colistin is a last-resort antibiotic for multidrug-resistant Gram-negative bacteria. Resistance arises through mutations in two-component systems (TCS) regulating the…
  pubmed Ahmad B, Ali Q, Azam S, Asghar M 等 2026 Jun 29 置信度 0.82
• Metabolic engineering strategies: utilizing different microbial strains and advanced technologies for the synthesis of high-valued terpenoids.
  Terpenoids represent the largest and most structurally diverse class of secondary metabolites, with extensive applications in the pharmaceutical, nutraceutical, cosmetic, agricultural, fragrance, and biofuel industries. The growing demand for these compounds h…
  pubmed Kamalesan A, Kumar KK, Nathan B, Perumal R 等 2026 Jul 27 置信度 0.82
• Burden and epidemiology of inguinal, femoral, and abdominal hernias in the Middle East and North Africa region from 1990 to 2023.
  There are limited studies on the burden of hernia in the Middle East and North Africa region. This study aimed to assess the burden of inguinal, femoral, and abdominal hernias by utilizing data from the Global Burden of Disease 2023 study.
  pubmed Hajizadeh A, Heidari P, Sadeghian A, Dehkordi AK 等 2026 Jun 5 置信度 0.82
• A smartphone-integrated isothermal amplification-based point-of-care testing platform for ultrasensitive detection of severe fever with thrombocytopenia syndrome virus.
  Severe fever with thrombocytopenia syndrome (SFTS), caused by the severe fever with thrombocytopenia syndrome virus (SFTSV), poses a serious public health threat due to its high fatality rate, and delayed diagnosis is strongly associated with disease progressi…
  pubmed Li W, Chen Y, Niu Y, Yang Y 等 2026 Oct 1 置信度 0.82
• Dual-input deep learning system for microbial identification from blood agar plates.
  The morphological classification of microbial cultures and colonies requires specialized knowledge and experience; therefore, automation in this field remains limited. This study examines the feasibility of automating the identification of pathogenic microbial…
  pubmed Naito T, Takei S, Misawa S, Kuribara M 等 2026 置信度 0.82
• Biofilm disruption by citronellol and geraniol against clinical uropathogenic Pseudomonas aeruginosa: an integrated in vitro and in silico investigation.
  Antimicrobial resistance (AMR) by Pseudomonas aeruginosa, within urinary tract and nosocomial infections, involves biofilm formation and quorum sensing (QS) constituting a major clinical challenge.
  pubmed Benaissa A, Tamfu AN, Bouali W, Bousselham A 等 2026 Jul 27 置信度 0.82