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• Field-programmable biological circuits and configurable (bio)logic blocks for distributed biological computing.
  Synthetic biology applications often require engineered computing structures, which can be programmed to process the information in a given way. However, programming of these structures usually requires significant amount of trial-and-error genetic engineering…
  europepmc Miha Moškon, Žiga Pušnik, Nikolaj Zimic, Miha Mraz 2020-11-11 置信度 0.80 Computer scienceField-programmable gate arrayDigital electronicsApplication-specific integrated circuitSynthetic biology
• An artificial immune system approach to automated program verification: Towards a theory of undecidability in biological computing
  An immune system inspired Artificial Immune System (AIS) algorithm is presented, and is used for the purposes of automated program verification. Relevant immunological concepts are discussed and the field of AIS is briefly reviewed. It is proposed to use this …
  europepmc Soumya Banerjee 2017 置信度 0.80
• Computing inspired by the brain: a journey from algorithms to organoids.
  The human brain has long served as a blueprint for computation, guiding evolution from early symbolic systems to modern deep learning models. Despite these advances, traditional computing systems remain fundamentally limited in mirroring the remarkable flexibi…
  europepmc 2026 置信度 0.80
• Liquid Metal Biomimicry: Bridging Fluidity and Biological Adaptability.
  Liquid metals, particularly gallium-based alloys, uniquely combine fluidic compliance with metallic conductivity, which makes them ideal candidates for biomimetic design. Rather than treating biomimicry as the mere imitation of biological forms, we argue that …
  europepmc 2026 置信度 0.80
• Biochemical and gene regulatory dynamics as reservoir-like substrates for natural computing.
  This perspective argues that biochemical reaction systems and gene regulatory systems can be interpreted not only as architectures of homeostatic control and adaptation, but also as reservoir-like dynamical substrates for natural computing. The claim is delibe…
  europepmc 2026 置信度 0.80
• A Non-Monotonic Reconfigurable Neural Unit with Dynamic Integration Control for Advanced Neuromorphic Computing
  Abstract The development of artificial neurons that emulate the rich adaptive dynamics of biological neural systems is pivotal for next-generation neuromorphic computing. Current hardware implementations, however, are fundamentally limited by fixed monotonic a…
  europepmc 2026 置信度 0.80
• BilboMD: a web-accessible SAXS and AlphaFold-guided modeling pipeline.
  BilboMD is a web-accessible platform that facilitates integrative modeling of flexible macromolecules using experimental small-angle X-ray and neutron scattering data. BilboMD combines a browser-based interface with high-performance back-end services hosted lo…
  europepmc 2026 置信度 0.80
• scRepresenter: a workflow for computing, integrating and benchmarking cellular representations in single-cell transcriptomics
  Motivation Single-cell RNA sequencing (scRNA-seq) has become an attractive tool for studying complex diseases, in which transient cell states affecting diverse cell populations characterise disease development and progression. However, due to data sparsity and…
  europepmc 2026 置信度 0.80
• A cybernetic framework for synthetic biological intelligence in the era of neural tissue engineering.
  Advances in synthetic biology and tissue engineering have enabled the design and assembly of neural constructs from first principles, renewing interest in cybernetics for understanding control, adaptation, and intelligence. To address shortcomings of artificia…
  europepmc 2026 置信度 0.80
• 2D Materials Powering Neuromorphic Intelligence.
  The exponential demand for energy-efficient and adaptive computing architectures drives the evolution of artificial intelligence (AI) and machine learning (ML). Neuromorphic computing, inspired by biological neural networks, overcomes the limitations of tradit…
  europepmc 2026 置信度 0.80
• A novel biological function-based method for mining core genes in rare disease with limited cases.
  Conventional high - throughput sequencing data analysis methods, relying on large cohorts, are unsuitable for rare diseases with few cases and poor at explaining gene biological functions. This study proposes a biological-function-based method for mining core …
  europepmc 2026 置信度 0.80
• MPLIF: Multi-parametric leaky integrate-and-fire neuron for spiking neural networks.
  Spiking Neural Networks (SNNs) have garnered significant attention due to their ability to process temporal information efficiently with low power consumption and high biological plausibility. In prevailing SNNs, spiking neuron models play a crucial role and h…
  europepmc 2026 置信度 0.80
• Ultraviolet-responsive IGZO synaptic transistors for photoelectric synergistic modulation and applications.
  Biological visual systems perceive information by processing light signals through the regulation of synaptic weights in the nervous system. Consequently, optoelectronic synaptic devices that directly respond to light stimuli and mimic synaptic plasticity hold…
  europepmc 2026 置信度 0.80
• Reducing acquisition time and radiation damage: data-driven subsampling for spectro-microscopy.
  Spectro-microscopy is an experimental technique which can be used to observe spatial variations in chemical state and changes in chemical state over time or under experimental conditions. As a result it has broad applications across areas such as energy materi…
  europepmc 2026 置信度 0.80
• Defect-Engineered Floating-Gate Synapses With Programmable Relaxation Dynamics for Multi-Timescale Neuromorphic Computing.
  The human brain processes temporal information across timescales spanning milliseconds to years through hierarchical memory systems, the biological capability that remains largely inaccessible to artificial neuromorphic hardware. Here, we present synapses with…
  europepmc 2026 置信度 0.80
• Low Power HfOx/TaOx stacked memristors with nanocolumn electrode for neuromorphic computing.
  Emulating biological synaptic behavior using the resistive random access memory (RRAM) is promising for neuromorphic applications. A stacked HfOx/TaOx RRAM model with nanocolumn electrode for low-power neuromorphic computing was constructed, and the finite ele…
  europepmc 2026 置信度 0.80
• Glycine molecule radical: Predicted properties and dipeptide formation
  The formation of the first peptide bonds under prebiotic conditions remains an open question. We used density functional theory calculations with the B3LYP functional to predict a novel pathway of peptide bond formation, which could have taken place without th…
  europepmc 2026 置信度 0.80
• Living bacterial reservoir computers for information processing and sensing.
  We introduce a systems-level approach to sensing and computing in which Escherichia coli acts as a living reservoir computer, performing complex information processing through its native growth responses without requiring genetic modification or specialized in…
  europepmc 2024 置信度 0.80
• Rethinking pathology image analysis through shuffling.
  Pathological examination is the current gold standard in cancer diagnosis, yet artificial intelligence (AI) methods still struggle to capture the multi-scale heterogeneity of tumor morphology across patients, tissues, and magnifications. Here, we introduce the…
  europepmc 2026 置信度 0.80
• Quantifying spike train synchrony and directionality: Measures and Applications.
  By introducing the twin concepts of reliability and precision along with the corresponding measures, Mainen and Sejnowski's seminal 1995 paper "Reliability of spike timing in neocortical neurons" (Mainen and Sejnowski 1995) paved the way for a new kind of quan…
  europepmc 2026 置信度 0.80
• Neuromorphic Computing: Foundations and the Case for Principle-Level Integration in AI Systems <em>Part I of IV</em>
  Synchronous with technological progress in Artificial Intelligence (AI), demands on underlying computing architectures are increasing rapidly. Neuromorphic computing (NMC) offers novel approaches to energy-efficient processing of time-dependent information and…
  europepmc 2026 置信度 0.80
• Virtual ultrasound machine operating in a GHz to MHz frequency range for particle-based biomedical simulations.
  Ultrasound-matter interactions underpin numerous biomedical and soft-matter applications, yet simulating these phenomena is challenging due to the large separation of viscous and sonic time scales. Continuum methods capture large-scale wave propagation but can…
  europepmc 2026 置信度 0.80
• Neuromorphic In-Memory Computing for Marine Visual-Auditory Perception.
  The exploration of marine environments is crucial, yet the extreme conditions of the deep-sea, combined with the segregated signal processing in current sensor technologies, lead to bulky systems, high energy consumption, and significant latency, which severel…
  europepmc 2026 置信度 0.80
• Redefining spiking neural networks through the lens of dynamical superspace.
  The convergence of neuroscience and artificial intelligence has positioned Spiking Neural Networks (SNNs) as one of the pivotal paradigms for future computing. However, the field faces a theoretical challenge: reconciling the mathematical clarity of static dee…
  europepmc 2026 置信度 0.80
• Vestibular reservoir computing
  Abstract Reservoir computing (RC) is a computational framework known for its training efficiency, making it ideal for physical hardware implementations. However, realizing the complex interconnectivity of traditional reservoirs in physical systems remains a si…
  europepmc 2026 置信度 0.80
• Data-driven system identification in cancer systems biology: A multiscale modeling approach to melanoma.
  Background and objective Developing systems biology models of cancer is critical for improving understanding of complex biological interactions and advancing appropriate therapeutic strategies. However, constructing complex, multiscale models that are easily p…
  europepmc 2026 置信度 0.80
• Quantum computing-assisted validation of a conserved macrophage suppression module shared by ASFV and PEDV.
  Background African swine fever virus (ASFV) and porcine epidemic diarrhea virus (PEDV) differ in viral biology and cellular tropism, yet both pathogens suppress macrophage-mediated immune responses in pigs. Objective To identify a conserved macrophage suppress…
  europepmc 2026 置信度 0.80
• Developing a binary communication protocol between biological neural networks using virtual white matter.
  Objective. Biological neural networks (BNNs) are composed of interconnected neurons, where a single neuron may connect to thousands of other neurons, and this interregional connectivity enables distributed computation across multiple nodes. Biocomputing exploi…
  europepmc 2026 置信度 0.80
• Accurate trajectory inference in time-series spatial transcriptomics with structurally-constrained optimal transport.
  New experimental and computational methods use genetic or gene expression observations with single cell resolution to study the relationship between single-cell molecular profiles and developmental trajectories. Most tissues contain spatially contiguous region…
  europepmc 2026 置信度 0.80
• Reconstructing lineage-constrained gene-program dynamics with PhyloFM
  Cell-fate dynamics are defined not only by where cells end, but by when fate programs emerge, diverge, and reshape population structure. Much recent effort has been devoted to reconstructing these dynamics from temporally resolved single-cell RNA-seq and spati…
  europepmc 2026 置信度 0.80
• A fast numerical integration scheme for clonal expansion processes on graphs.
  Compound birth-death processes are widely used to model the age-incidence curves of many cancers. There are efficient schemes for directly computing the relevant probability distributions in the context of linear multi-stage clonal expansion (MSCE) models. How…
  europepmc 2026 置信度 0.80
• Biologically inspired mechanisms for enhancing robustness in EEG signal modeling: Challenges, opportunities, and perspectives.
  The human brain maintains functional stability under changing conditions through interacting processes that include synaptic plasticity, homeostatic regulation, adaptive connectivity, and oscillatory dynamics. By contrast, electroencephalographic (EEG) recordi…
  europepmc 2026 置信度 0.80
• CARIBOU: Computational AI Research Interface for Bioinformatics, Omics, and Unifying Agents
  SUMMARY The growing gap between biological data generation and the availability of expert analysts motivates the development of AI systems capable of autonomously performing meaningful computational biology workflows. Here, we present CARIBOU (Computational AI…
  europepmc 2026 置信度 0.80
• Dynamic neural trajectories of emotion bias processing in treatment-resistant depression: A novel perspective and computational approach.
  Emotional bias processing may serve as a core underpinning of the onset and persistence of treatment-resistant depression (TRD). However, its neural mechanisms remain unclear. A comprehensive understanding of the mechanisms requires elucidation of the computat…
  europepmc 2026 置信度 0.80
• Artificial sparse neuron dendrites for visual information inference.
  In the human brain, dendrites exhibit nonlinear integration and sparse parallel processing capabilities, which can effectively perform visual tasks by integrating only a small subset of neuronal signals and play a crucial role in high-level information inferen…
  europepmc 2026 置信度 0.80
• Fusing imaging and metabolic modeling via multimodal deep learning in ovarian cancer.
  Integrating genotype (e.g., transcriptomics), phenotype (e.g., imaging), and tumor microenvironment (e.g., metabolomics) is crucial to elucidating the molecular basis of ovarian cancer. However, there is a lack of robust multimodal integration methods when onl…
  europepmc 2026 置信度 0.80
• Motional Narrowing Rescues Entanglement in Biological Radical-Pair Systems: Quantum Error Correction and Reservoir Computing Beyond the Breaking Threshold
  Abstract Biological radical-pair systems operate at decoherence rates γeff = 3.25–4.55, far exceeding the entanglement-breaking threshold γc ≈ 0.3 (channel-model-dependent). Standard quantum error correction provably fails (Q1 = 0). We identify three escape ro…
  europepmc Hikaru Wakaura, Taiki Tanimae 2026 置信度 0.80
• Micro-functional protein complexes mining in biological intelligent computing: a weighted network approach.
  Identifying protein complexes is of great significance for drug target discovery and understanding disease mechanisms. Recognizing the variations of different protein complexes in individual organisms aids in the development of personalized treatment strategie…
  europepmc 2026 置信度 0.80
• Development and validation of an electronic health record-based frailty index in the UK Biobank.
  Background Frailty, an age-related loss of the ability to withstand stressors, is commonly measured using health deficit indices, often using survey or questionnaire data. We aimed to develop an electronic frailty index (eFI) using electronic health record (EH…
  europepmc 2026 置信度 0.80
• Ion-modulated oxide-based neuromorphic transistors for spatiotemporal information processing.
  Unlike energy-intensive von Neumann systems, the human brain efficiently processes complex spatiotemporal information utilizing slow, dissipative ionic dynamics. To emulate this, ion-modulated oxide-based neuromorphic transistors have emerged as a compelling h…
  europepmc 2026 置信度 0.80
• Unbalanced Perturbation Dynamics For Cell Fate Design
  Large-scale single-cell perturbation sequencing provides an unprecedented opportunity to construct virtual cells for the in silico simulation of cellular responses and the inverse design of optimal interventions. However, most perturbation-response models trea…
  europepmc 2026 置信度 0.80
• Drug Repositioning Based on Expert Knowledge Augmented Graph Neural Network.
  Drug repositioning is critical in accelerating drug discovery, which identifies new indications for existing drugs by modeling drug-disease associations. Compared to traditional methods, graph neural networks (GNNs) have recently gained widespread attention du…
  europepmc 2026 置信度 0.80
• Ultralow Energy Optoelectronic Synapse Using Halide Perovskite/Organic Semiconductor Heterostructure for Neuromorphic Computing, Optical Logic and Wireless Communication.
  With the advancement of artificial intelligence, the emulation of biological neural processes through neuromorphic computing has gained significant attention. Artificial optoelectronic synapses have emerged as promising components for neuromorphic computing du…
  europepmc 2026 置信度 0.80
• Electrochemical in-biosensing computing.
  Artificial intelligence (AI)-aided electrochemical biosensing is becoming integral parts in numerous scenarios. However, existing systems generally perform algorithms in external signal processing units. The necessity of analog-to-digital conversion and data t…
  europepmc 2026 置信度 0.80
• Topological acoustic synapse for high-dimensional neuromorphic computing.
  The human brain performs complex, high-dimensional (HD) computations, such as causal reasoning, counterfactual thinking, and abstraction, with ~10 11 neurons while consuming ~20 watts of power. Neuromorphic computing seeks similar efficiency, but current devic…
  europepmc 2026 置信度 0.80
• Pathway Controlled Phase Separation of Minimal Building Blocks Utilizing a Dissociative Chemical Transformation.
  Metastable states are utilized by biology to power the construction of large and motile macromolecules and also to realize out-of-equilibrium phase separation. Energy transduction from orthogonal and unrelated exergonic reactions drives the contra-thermodynami…
  europepmc 2026 置信度 0.80
• Why family medicine requires a paradigm shift from linear guidelines to complexity science.
  Evidence-based medicine (EBM) has standardised care by reducing variance, yet its reliance on linear, reductionist models often fails the patient in primary care, especially the multimorbid patient. Current clinical guidelines assume that biological inputs lea…
  europepmc 2026 置信度 0.80
• Codepoietic biological evolution: From the origin of life to eukaryogenesis.
  Evolution is an intrinsic property of autopoietic systems performing natural computation, which is based on an internal formal self-description representing the arrangement of digital and analog coding structures. Autopoietic systems are capable of assigning n…
  europepmc 2026 置信度 0.80
• A low-molecular-weight α-glucan PPS2-A derived from potato starch fermentation by Antarctic Penicillium chrysogenum MS-02: Structural characterization and immunomodulatory activity.
  Glucan, a potent immunomodulator with well-established pharmacological activities, can be efficiently produced through the microbial transformation of low-value substrates. Here, the psychrotolerant Antarctic fungus Penicillium chrysogenum MS-02 was cultivated…
  europepmc 2026 置信度 0.80
• Ferroelectric Devices for In-Memory and In-Sensor Computing.
  Inspired by biological neural and sensory systems, the in-memory computing and in-sensor computing paradigms have emerged, which integrate computation with memory and processing with sensor respectively, offering a promising solution to address latency and pow…
  europepmc 2026 置信度 0.80
• Bioinspired Nanofluidic Memristors Based on Polyelectrolyte Conformation for Synaptic Learning and in-Memory Logic Computing.
  Bioinspired neuromorphic and in-memory computing requires devices that store and process information through ionic dynamics analogous to biological synapses. Here, we report a polyelectrolyte conformational nanofluidic memristor (PCM) that integrates synaptic …
  europepmc 2026 置信度 0.80
• Intelligent tool orchestration for rapid mechanistic model prototyping: MCP servers as AI-biology interfaces.
  Constructing multicellular mechanistic models traditionally requires extensive time and computational expertise. We introduce intelligent tool orchestration via Model Context Protocol (MCP) servers, enabling Large Language Model (LLM) agents to act as AI labor…
  europepmc 2026 置信度 0.80
• Top 10 ground challenges in microsystems and nanoengineering.
  europepmc 2026 置信度 0.80
• Genetic overlap between treatment-resistant schizophrenia and smoking initiation.
  Background Early detection of treatment-resistant schizophrenia (TRS) is of substantial clinical importance. While TRS is heritable, the associated genetic variants have been difficult to identify. Cigarette smoking is associated with non-response to antipsych…
  europepmc 2026 置信度 0.80
• Graph-Embedded Deep Generative Clustering for Single-Cell Multi-Omics Data Integration.
  The advancement of sequencing technologies has generated an unprecedented volume of single-cell multi-omics data, providing new opportunities for biological discovery and medical research. However, due to the high heterogeneity across different omics types, ef…
  europepmc 2026 置信度 0.80
• Quantum computing for biotechnological innovation: transformative potential in biomedicine and drug discovery.
  Quantum computing has emerged as a potential catalyst for addressing computational bottlenecks that increasingly constrain biotechnologies, including drug discovery, structural biology, and precision medicine. As biological datasets grow in scale and complexit…
  europepmc 2026 置信度 0.80
• Empowering Chemical Structures with Biological Insights for Scalable Phenotypic Virtual Screening.
  Motivation The scalable identification of bioactive compounds is essential for contemporary drug discovery. This process faces a key trade-off: structural screening offers scalability but lacks biological context, whereas high-content phenotypic profiling prov…
  europepmc 2026 置信度 0.80
• Computational screening of antimicrobial peptide analogs targeting AdeB efflux transporter protein in Acinetobacter baumannii associated with multidrug resistance.
  Overexpression of the AdeABC efflux pump is crucial in conferring multidrug resistance (MDR) in Acinetobacter baumannii (A. baumannii). Its primary subunit, AdeB, recognizes and pumps out aminoglycosides, carbapenems, and several other classes of antibiotics f…
  europepmc 2026 置信度 0.80
• Combining sampling and attractor dynamics in spiking models of head direction systems.
  Neural populations can maintain stable representations of navigation-related variables while integrating uncertain sensory signals. Experimental evidence showed that the precision of head-direction (HD) representations in flies and mice depends on the reliabil…
  europepmc 2026 置信度 0.80
• Biocomputing: Beyond the Hype.
  Unlabelled Biocomputing is a nascent but rapidly developing field at the intersection of biology and computer science. In this News and Perspectives article, JMIR Correspondent Simon Spichak reports on its current and potential applications for health care res…
  europepmc 2026 置信度 0.80
• Neuromorphic Near-Sensor and In-Sensor Computing Enabled by Next-Generation Material-Based Sensors.
  The massive influx of continuous, real-time environmental data demands highly energy-efficient and low-latency sensory processing. Conventional artificial sensory systems are limited by severe data transfer overhead issues due to physically separated processin…
  pubmed Jung SY, Kim GY, Kim S, Seo H 等 2026 置信度 0.82
• Multi-target Agents in Complex Diseases: From Design Principles to Therapeutic Applications.
  Introduction Multifactorial complex diseases such as cancer, neurodegeneration, and infections are poorly treated with traditional single-target therapies because biological networks are redundant and adaptively resistant. Methods A comprehensive literature re…
  europepmc 2026 置信度 0.80
• A Learning-Guided Meta-Heuristic Approach for Task Offloading in Four-Tier IoT Networks: A Hybrid UCB-ACO Algorithm.
  The rapid development and expansion of the Internet of Things (IoT) ecosystem require managing increasing computational demands with the aid of advanced hierarchical architectures. The integration of a complete four-tier hierarchy-including Mobile, Edge, Fog, …
  europepmc 2026 置信度 0.80
• Principal Components Analysis Fails to Recover Phylogenetic Structure in Hominins.
  Objectives Paleoanthropologists often utilize geometric morphometrics and principal components analysis (PCA) to interpret shape variation within the hominin fossil record. It is common practice to interpret proximity in principal components (PC) space among t…
  europepmc 2026 置信度 0.80
• Bioprocess optimisation via joint machine learning and metabolic modelling.
  Optimisation of the design-build-test-learn cycle remains a bottleneck for developing and efficiently manufacturing the next generation of bioproducts. To address this challenge, research has traditionally focused on either data-driven or mechanistic modelling…
  europepmc 2026 置信度 0.80
• Grain Boundary Enabled Diamond Memristor.
  Diamond has been recognized as the ultimate semiconductor due to its ultra-wide bandgap, exceptional carrier mobility, high breakdown voltage, and superior thermal conductivity. However, its application in memristors is significantly limited by challenges in m…
  europepmc 2026 置信度 0.80
• Adaptive memristor-based LIF neuron circuit for energy efficient SNN crossbar array.
  Spiking neural networks (SNN) provide superior potential for neuromorphic architecture implementation due to its similarity to biological brain structures and exceptional computing efficiency. Neurons are the fundamental elements of SNN, and the incorporation …
  europepmc 2026 置信度 0.80
• Link Prediction Based on Subgraph Learning in Biological Networks.
  Recently, link prediction (LP) based on graph neural networks (GNNs) methods has achieved notable successes in biological networks (BNs), since it can reveal the organizational principles, functional mechanisms, and dynamic properties of biological systems. Ho…
  europepmc 2026 置信度 0.80
• Integrating multimodal features with deep learning for protein solubility prediction.
  Protein solubility prediction holds significant importance in the fields of biotechnology and medicine. With the continual advancements of computational and experimental techniques such as protein design, enzyme mining, and directed evolution, accurate predict…
  europepmc 2026 置信度 0.80
• Low-latency neuromorphic closed-loop control of hippocampal ripples <i>in vivo</i>
  Real-time closed-loop neuromodulation, in which stimulation is precisely timed to ongoing brain dynamics, holds transformative potential for treating neurological disorders and probing neural circuit function. However, it requires low-latency, energy-efficient…
  europepmc 2026 置信度 0.80
• Quantum Computing and Quantum Technologies in Drug Discovery and Therapeutics: Evidence, Benchmarking, and Translational Integration.
  Quantum technologies-quantum computing, quantum sensing, and quantum-enabled materials-are increasingly proposed as tools to accelerate drug discovery. Yet "quantum advantage" is frequently asserted without standardized benchmarks, clinically meaningful endpoi…
  europepmc 2026 置信度 0.80
• Quantum bioinformatics: a systematic review of methods, trends, and challenges.
  Modern bioinformatics faces escalating challenges stemming from both the inherent computational hardness of many fundamental problems and the rapidly growing scale and complexity of biological data, increasingly limiting the effectiveness of classical computat…
  europepmc 2026 置信度 0.80
• Hierarchical quantum circuit model of microtubule for the Orch-OR theory.
  The Orch-OR theory has been proposed as a framework for explaining consciousness based on quantum-gravitational effects in microtubules. To further support and examine this theory, a more concrete quantum circuit model is required, one that can be theoreticall…
  europepmc 2026 置信度 0.80
• A fully-CMOS spiking LIF neuron implementation for optimized STDP learning on memristor.
  The growing demand for fast and energy-efficient computing has motivated the development of neuromorphic hardware inspired by biological neural systems. Spiking neural networks (SNNs), as the third generation of neural networks, offer an event-driven and highl…
  europepmc 2026 置信度 0.80
• Virtual cell: Current perspectives and future prospects.
  Virtual cell is an emerging technology that integrates multiple disciplines, including biology, computer science, and artificial intelligence, to simulate cellular structures and functions. Compared with traditional methods, virtual cell technology offers a mo…
  europepmc 2026 置信度 0.80
• ToxMet: a web tool for toxicogenomic data analysis using genome-scale metabolic modeling.
  Chemical toxicity assessment commonly includes in vivo rat exposure experiments, with transcriptomic measurements collected at various exposure times and chemical doses. The mechanisms underlying chemical-induced toxicity are then inferred by analyzing changes…
  europepmc 2026 置信度 0.80
• A biological age assessment system based on nine-dimensional weighting framework and AI-driven proteomics
  Abstract Accurate quantification of biological aging remains a significant challenge due to the complex and multidimensional nature of physiological decline. While single-parameter biomarkers provide specific insights, an integrated computational framework tha…
  europepmc 2026 置信度 0.80
• Correction to: Pulse oximeter bench tests under different simulated skin tones.
  The original version of this article unfortunately contained mistakes. A reader alerted us to an issue in Table3. We confirm that the ITA° value for the 2.5mg/mL (J) melanin filter is + 69.17°, as originally reported. However, the corresponding b* entry was ty…
  europepmc 2026 置信度 0.80
• In silico genomic analysis of resistome, virulome, and mobilome of β-lactamase-producing Klebsiella pneumoniae.
  Klebsiella pneumoniae (K. pneumoniae) is a major multidrug-resistant pathogen associated with nosocomial infections, particularly among immunocompromised patients, and contributes significantly to global morbidity and mortality. This study provides a comprehen…
  europepmc 2026 置信度 0.80
• Engineering the substrate scope of the thermostable phenolic acid decarboxylase N31 towards sterically hindered phenolic acids.
  Phenolic acid decarboxylases (PADs) convert bio-based hydroxycinnamic acids into valuable hydroxystyrene monomers under mild reaction conditions. These compounds are in high demand in polymer production, cosmetics, and flavoring. Especially 4-vinyl syringol, t…
  europepmc 2026 置信度 0.80
• To cleave or not to cleave: a systemic evaluation of DSS versus DSSO for cross-linking mass spectrometry analysis.
  Cross-linking mass spectrometry is a powerful method for structural analysis, but choosing between cleavable and non-cleavable cross-linkers remains challenging. We rigorously compared non-cleavable DSS with cleavable DSSO and found that DSS consistently yield…
  europepmc 2026 置信度 0.80
• Computing topological parameters of biological networks
  Abstract Summary: Rapidly increasing amounts of molecular interaction data are being produced by various experimental techniques and computational prediction methods. In order to gain insight into the organization and structure of the resultant large complex n…
  semanticscholar Y. Assenov, Fidel Ramírez, Sven-Eric Schelhorn, Thomas Lengauer 等 2007-11-15 置信度 0.74 Bioinform.Computer sciencePlug-inBiological networkIntersection (aeronautics)
• Biological computing
  semanticscholar S. Kurtz, Stephen R. Mahaney, J. Royer, J. Simon 等 1997-01-01 置信度 0.74 Computer science
• Active transport in biological computing
  Early papers on biological computing focussed on combinatorial and algorithmic issues, and worked with intentionally oversimplified chemical models. In this paper, we reintroduce complexity to the chemical model by considering the effect problem size has on th…
  semanticscholar S. Kurtz, Stephen R. Mahaney, J. Royer, Janos Simon 等 1996 置信度 0.74 DNA Based ComputersComputer science
• Towards spike-based machine intelligence with neuromorphic computing
  semanticscholar K. Roy, Akhilesh R. Jaiswal, P. Panda, Kaushik Roy 等 2019-10-02 置信度 0.74 NatureNeuromorphic engineeringComputer scienceSpike (software development)Spiking neural network
• Functional Topology Classification of Biological Computing Networks
  semanticscholar P. Blinder, Itay Baruchi, V. Volman, H. Levine 等 2005-09-01 置信度 0.74 Natural ComputingTopology (electrical circuits)Biological networkComputer scienceNode (physics)
• Metabolic perceptrons for neural computing in biological systems
  Synthetic biological circuits are promising tools for developing sophisticated systems for medical, industrial, and environmental applications. So far, circuit implementations commonly rely on gene expression regulation for information processing using digital…
  semanticscholar A. Pandi, Mathilde Koch, Peter L. Voyvodic, Paul Soudier 等 2019-04-23 置信度 0.74 Nature CommunicationsPerceptronComputer scienceScalabilityAdder
• Digital and biological computing in organizations
  openalex Roberto R. Kampfner 2002-01-01 置信度 0.72 AdaptabilityInterfacingExploitComputer scienceInformation processing
• Biomolecular computing systems: principles, progress and potential
  openalex Yaakov Benenson 2012-06-12 置信度 0.72 Computer scienceNatural computingComputationBiochemical engineeringNanotechnology
• Biological neurons act as generalization filters in reservoir computing
  Reservoir computing is a machine learning paradigm that transforms the transient dynamics of high-dimensional nonlinear systems for processing time-series data. Although the paradigm was initially proposed to model information processing in the mammalian corte…
  openalex Takuma Sumi, Hideaki Yamamoto, Yuichi Katori, Koki Ito 等 2023-06-12 置信度 0.72 Reservoir computingComputer scienceModular designGeneralizationArtificial intelligence
• Computing Platforms for Big Biological Data Analytics: Perspectives and Challenges
  The last decade has witnessed an explosion in the amount of available biological sequence data, due to the rapid progress of high-throughput sequencing projects. However, the biological data amount is becoming so great that traditional data analysis platforms …
  openalex Zekun Yin, Haidong Lan, Guangming Tan, Mian Lu 等 2017-01-01 置信度 0.72 Big dataBiological dataComputer scienceData scienceScalability
• Positron emission tomography provides molecular imaging of biological processes
  Diseases are biological processes, and molecular imaging with positron emission tomography (PET) is sensitive to and informative of these processes. This is illustrated by detection of biological abnormalities in neurological disorders with no computed tomogra…
  openalex Michael E. Phelps 2000-08-01 置信度 0.72 Positron emission tomographyMolecular imagingPreclinical imagingMagnetic resonance imagingIn vivo
• Biological Computing
  This open access book comprehensively introduces biocomputing, focusing on its foundational theories, experimental operations, and computational models. Biocomputing represents an innovative computational paradigm that leverages biomolecules as a carrier for p…
  openalex Jin Xu 2025-01-01 置信度 0.72 Computer science
• Fitting the Negative Binomial Distribution to Biological Data
  In studying the occurrence of plants and animals in nature, the number of individuals may be counted in each of many equal units of space or time. The original counts can be summarized in a frequency distribution, showing the number of units containing x = 0, …
  openalex C. I. Bliss, Ronald Aylmer Fisher 1953-06-01 置信度 0.72 Poisson distributionNegative binomial distributionMathematicsStatisticsSeries (stratigraphy)
• Mimicking Biological Synaptic Functionality with an Indium Phosphide Synaptic Device on Silicon for Scalable Neuromorphic Computing
  Neuromorphic or “brain-like” computation is a leading candidate for efficient, fault-tolerant processing of large-scale data as well as real-time sensing and transduction of complex multivariate systems and networks such as self-driving vehicles or Internet of…
  openalex Debarghya Sarkar, Jun Tao, Wei Wang, Qingfeng Lin 等 2018-01-12 置信度 0.72 Neuromorphic engineeringScalabilityComputer scienceMaterials scienceSynapse
• Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects
  Tissue hypoxia results from an inadequate supply of oxygen (O(2)) that compromises biologic functions. Evidence from experimental and clinical studies increasingly points to a fundamental role for hypoxia in solid tumors. Hypoxia in tumors is primarily a patho…
  openalex Michael Höckel, Peter Vaupel 2001-02-21 置信度 0.72 Hypoxia (environmental)Tumor hypoxiaHomeostasisMicrocirculationCancer research
• Patient radiation biological risk in computed tomography angiography procedure
  Computed tomography angiography (CTA) has become the most valuable imaging modality for the diagnosis of blood vessel diseases; however, patients are exposed to high radiation doses and the probability of cancer and other biological effects is increased. The o…
  openalex M. Alkhorayef, E. Babikir, Abdullah Alrushoud, Huda I. Almohammed 等 2016-01-11 置信度 0.72 MedicinePelvisRadiologyEffective dose (radiation)Abdomen
• The use of positron emission tomography/computed tomography imaging in radiation therapy: a phantom study for setting internal target volume of biological target volume
  BACKGROUND: Fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) is an important method for detecting tumours, planning radiotherapy treatment, and evaluating treatment responses. However, using the standardized uptake value…
  openalex Wataru Kawakami, Akihiro Takemura, Kunihiko Yokoyama, Kenichi Nakajima 等 2015-01-07 置信度 0.72 MedicinePositron emission tomographyImaging phantomNuclear medicineVolume (thermodynamics)
• Recent advances in physical reservoir computing: A review
  Reservoir computing is a computational framework suited for temporal/sequential data processing. It is derived from several recurrent neural network models, including echo state networks and liquid state machines. A reservoir computing system consists of a res…
  openalex Gouhei Tanaka, Toshiyuki Yamane, J. B. Héroux, Ryosho Nakane 等 2019-03-20 置信度 0.72 Reservoir computingComputer scienceArtificial neural networkReservoir modelingArtificial intelligence
• Loneliness, social isolation, and behavioral and biological health indicators in older adults.
  OBJECTIVE: A number of mechanisms have been proposed through which social isolation and loneliness may affect health, including health-related behavioral and biological factors. However, it is unclear to what extent isolation and loneliness are independently a…
  openalex Aparna Shankar, Anne McMunn, James Banks, Andrew Steptoe 2011-01-01 置信度 0.72 LonelinessSocial isolationAffect (linguistics)UCLA Loneliness ScalePsychology