-
crossref
Nate Lewis, Peter Weinberger
2017-08-30T20:32:25Z
置信度 0.70
-
La computación molecular es una disciplina que se ocupa del diseño e implementación de dispositivos para el procesamiento de información sobre un sustrato biológico, como el ácido desoxirribonucleico (ADN), el ácido ribonucleico (ARN) o las proteínas. Desde qu…
crossref
Iñaki Sainz de Murieta Fuentes
2022-10-10T07:35:10Z
置信度 0.70
-
Natural biological systems achieve precise cellular control through multidimensional signaling architectures that integrate sequence specificity, structural dynamics, and conformational switching. While synthetic DNA networks have been engineered primarily usi…
europepmc
2026
置信度 0.80
-
DNA strand displacement reactions (SDR) have enabled the development of biosensing devices, molecular machines, and molecular computing. However, the need for high sequence orthogonality poses a major challenge to the modular integration and scaling of DNA SDR…
europepmc
2026
置信度 0.80
-
Conventional silicon computing is constrained by energy demands, limited parallelism, and poor compatibility with living systems, motivating the exploration of molecular alternatives. Here, we realize Brownian DNA computing, a hitherto theoretical framework, f…
europepmc
2025
置信度 0.80
-
Computation has consistently served as a significant indicator and direction of social development, and volume, speed, and accuracy are critical factors during development. To accelerate this computational process, various advanced technologies and constantly …
europepmc
2025
置信度 0.80
-
Chimeric antigen receptor (CAR) T cells, a promising cancer therapeutics, still face challenges in safety and efficacy due to the incapability to precisely regulate T cell activation. Here we develop a DNA-logic CAR (DL-CAR) system that enables programmable ta…
europepmc
2026
置信度 0.80
-
Abstract As digital healthcare systems increasingly rely on electronic medical records, secure and high-quality encryption mechanisms are essential to prevent unauthorized access and cyber threats. This study proposes a novel Hardy–Weinberg equilibrium-inspire…
europepmc
2026
置信度 0.80
-
DNA computing circuits leverage molecular interactions to construct a highly parallel and biologically compatible information processing paradigm. However, their development has been constrained by a critical gap between intrinsic computational parallelism and…
europepmc
2025
置信度 0.80
-
Let e be a fixed positive integer and n1,n2 be odd positive integers. The main objective of this article is to investigate the algebraic structure of double cyclic codes of length (n1,n2) over the finite chain ring Re = F4e+vF4e, where v2=0. Building upon this…
europepmc
2025
置信度 0.80
-
Abstract With the rise of digital healthcare, ensuring the confidentiality of medical data has become increasingly critical. The widespread adoption of electronic medical records requires robust encryption techniques to protect sensitive patient information fr…
europepmc
2025
置信度 0.80
-
DNA-based molecular computing has emerged as a promising alternative for performing sophisticated computational processes, holding the potential to advance the field of biosensing and clinical diagnosis. However, the majority of DNA computing systems rely excl…
europepmc
2025
置信度 0.80
-
europepmc
Stéphane D. Lemaire, David Turek, Dave Landsman, Marthe Colotte 等
2025
置信度 0.80
Computer scienceDNANanotechnologyData scienceMaterials science
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Molecular subtype classification of heterogeneous breast cancer is crucial for personalized therapies yet is limited by the low specificity of conventional single-target diagnosis systems. Herein, we developed a compact and versatile catalytic DNA computing (C…
europepmc
2025
置信度 0.80
-
In biological systems, molecular network functionalities are usually switched in a flexible, facile, and programmable manner. Mimicking this, substantial studies are directed towards developing synthetic DNA networks that exhibit similar function-switching cap…
europepmc
2025
置信度 0.80
-
Early and accurate diagnosis of breast cancer, due to the complexity and cost of conventional methods, remains a major challenge. A new DNA computing-based detection processor is proposed for high-precision breast cancer diagnosis through miRNA biomarker analy…
europepmc
2026
置信度 0.80
-
europepmc
2024
置信度 0.80
-
Neural networks enable the processing of large, complex data sets with applications in disease diagnosis, cell profiling, and drug discovery. Beyond electronic computers, neural networks have been implemented using programmable biomolecules such as DNA; this c…
europepmc
2024
置信度 0.80
-
DNA computing is regarded as one of the most promising candidates for the next generation of molecular computers, utilizing DNA to execute Boolean logic operations. In recent decades, DNA computing has garnered widespread attention due to its powerful programm…
europepmc
2024
置信度 0.80
-
DNA computing leverages molecular reactions to achieve diverse information processing functions. Recently developed DNA origami registers, which could be integrated with DNA computing circuits, allow signal transmission between these circuits, enabling DNA cir…
europepmc
2024
置信度 0.80
-
DNA computing represents a subfield of molecular computing with the potential to become a significant area of next-generation computation due to the high programmability inherent in the sequence-dependent molecular behaviour of DNA. Recent studies in DNA compu…
europepmc
Sotaro Takiguchi, Nanami Takeuchi, Vasily Shenshin, Guillaume Gines 等
2024-10-29
置信度 0.80
NanoporeComputer scienceDNA computingNanopore sequencingDecoding methods
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With the fast growth of smartphones and digital cameras, massive images are generated every day in the world. They are easily transmitted on the insecure channel-Internet. It has been a hot spot for protecting sensitive images during communication. A new crypt…
europepmc
2024
置信度 0.80
-
DNA-based molecular computing has evolved to encompass a diverse range of functions, demonstrating substantial promise for both highly parallel computing and various biomedical applications. Recent advances in DNA computing systems based on surface reactions h…
europepmc
2024
置信度 0.80
-
This work developed DNA amplifier logic gates (AND-OR, OR-AND, FAN-IN, FAN-OUT, and 4-bit square-root circuits) using a flap endonuclease 1 (FEN1)-catalyzed signal amplification reaction, for the fastest and compact DNA computing. Moreover, the logic circuit c…
europepmc
2024
置信度 0.80
-
DNA computing is a new pattern of computing that combines biotechnology and information technology. As a new technology born in less than three decades, it has developed at an extremely rapid rate, which can be attributed to its advantages, including high para…
europepmc
2024
置信度 0.80
-
DNA computing harnesses the immense potential of DNA molecules to enable sophisticated and transformative computational processes but is hindered by low computing speed. Here, we propose freeze-thaw cycling as a simple yet powerful method for high-speed DNA co…
europepmc
2023
置信度 0.80
-
Background Differentiating between different states in nucleic acid circuits is crucial for various biological applications. One approach, there is a requirement for complicated sequential summation, which can be excessive for practical purposes. By selectivel…
europepmc
2024
置信度 0.80
-
Accurate classification of tumor cells is of importance for cancer diagnosis and further therapy. In this study, we develop multimolecular marker-activated transmembrane DNA computing systems (MTD). Employing the cell membrane as a native gate, the MTD system …
europepmc
2024
置信度 0.80
-
The traveling car renter problem (TCRP) is a variant of the Traveling Salesman Problem (TSP) wherein the salesman utilizes rented cars for travel. The primary objective of this problem is to identify a solution that minimizes the cumulative operating costs. Gi…
europepmc
2024
置信度 0.80
-
DNA circuits, as a type of biochemical system, have the capability to synchronize the perception of molecular information with a chemical reaction response and directly process the molecular characteristic information in biological activities, making them a cr…
europepmc
2024
置信度 0.80
-
DNA computing has emerged as a promising alternative to achieve programmable behaviors in chemistry by repurposing the nucleic acid molecules into chemical hardware upon which synthetic chemical programs can be executed. These chemical programs are capable of …
europepmc
2023
置信度 0.80
-
Early identification of key biomarkers of malignant cancer is vital for patients' prognosis and therapies. There is research demonstrating that microRNAs are important biomarkers for cancer analysis. In this article, we used the DNA strand displacement mechani…
europepmc
2022
置信度 0.80
-
The majority of biological reactions in the cytoplasm of living cells occur via enzymatic cascade reactions. To achieve efficient enzyme cascade reactions mimicking the proximity conditions of enzymes in the cytoplasm, the proximity of each enzyme, creating a …
europepmc
2023
置信度 0.80
-
DNA has emerged as a powerful substrate for programming information processing machines at the nanoscale. Among the DNA computing primitives used today, DNA strand displacement (DSD) is arguably the most popular, with DSD-based circuit applications ranging fro…
europepmc
2022
置信度 0.80
-
The predictability of Watson-Crick base pairing provides unique structural programmability to DNA, facilitating the development and application of biomolecules in biocomputing. However, in DNA-based biocomputing, the scale of operation that can be achieved by …
europepmc
2023
置信度 0.80
-
DNA has emerged as a powerful substrate for programming information processing machines at the nanoscale. Among the DNA computing primitives used today, DNA strand displacement (DSD) is arguably the most popular, with DSD-based circuit applications ranging fro…
europepmc
2021
置信度 0.80
-
Clustered regularly interspaced short palindromic repeats (CRISPR) technology has unique specificity for recognizing and cleaving target DNA complementary to the CRISPR guide sequence. Here, we report on a CRISPR-powered DNA computing and digital display syste…
europepmc
2021
置信度 0.80
-
DNA-based Boolean logic computing has emerged as a leading technique in biosensing, diagnosis, and therapeutics. Due to the development of the biological and chemical methods, especially the toehold-mediated DNA strand displacement (TMSD) reaction, different l…
europepmc
2022
置信度 0.80
-
Abstract Splicing systems are a form of DNA computing as they mimic the recombination process among DNA molecules. This work discusses the use of splicing systems to build automatic tools for reproducing human beings' creativity, in the context of automatic mu…
europepmc
2021
置信度 0.80
-
DNA logic nanodevices are powerful tools for both molecular computing tasks and smart bioanalytical applications. Nevertheless, the hour-level operation time and high cost caused by the frequent redesign/reconstruction of gates, tedious strand-displacement rea…
europepmc
2023
置信度 0.80
-
DNA-based Boolean logic gates (for example, AND, OR, and NOT) can be assembled into complex computational circuits that generate an output signal in response to specific patterns of oligonucleotide inputs. However, the fundamental nature of NOT gates, which co…
europepmc
2021
置信度 0.80
-
As the demand for high-performance computing continues to grow, traditional computing models are facing unprecedented challenges. Among the many emerging computing technologies, DNA computing has attracted much attention due to its low energy consumption and p…
europepmc
2021
置信度 0.80
-
DNA-based Boolean logic gates (AND, OR and NOT) can be assembled into complex computational circuits that generate an output signal in response to specific patterns of oligonucleotide inputs. However, the fundamental nature of NOT gates, which convert the abse…
europepmc
2020
置信度 0.80
-
The Family Traveling Salesperson Problem (FTSP) is a variant of the Traveling Salesperson Problem (TSP), in which all vertices are divided into several different families, and the goal of the problem is to find a loop that concatenates a specified number of ve…
europepmc
2022
置信度 0.80
-
Physical isolation of molecular computing elements holds the potential for increasing system complexity by enabling the reuse of standardized components and by protecting the components from environmental degradation. However, once elements have been compartme…
europepmc
2019
置信度 0.80
-
europepmc
2017
置信度 0.80
-
Biocomputing, especially DNA, computing has got great development. It is widely used in information security. In this paper, a novel algorithm of reversible data hiding based on DNA computing is proposed. Inspired by the algorithm of histogram modification, wh…
europepmc
2017
置信度 0.80
-
Based on a set of known biological operations, a general resolution of intractable problems in polynomial time through DNA Computing is presented. This scheme has been applied to solve two NP-Hard problems (Minimization of Open Stacks Problem and Matrix Bandwi…
europepmc
2016
置信度 0.80
-
DNA (deoxyribonucleic acid) computing that is a new computation model based on DNA molecules for information storage has been increasingly used for optimization and data analysis in recent years. However, DNA computing algorithm has some limitations in terms o…
europepmc
2013
置信度 0.80
-
europepmc
2013
置信度 0.80
-
Conformational and configurational states of the sugar-phosphate backbone play an important role in DNA transcriptional and RNA translational events. In particular, the geometric parameters of the sugar ring dictate the degree of pucker, influencing the overal…
europepmc
2026
置信度 0.80
-
Large-scale genomic language models (gLMs) hold promise for modeling gene regulation, yet their ability to capture personal gene expression variations remains unresolved. We developed xDecoder, a unified decoding framework that utilizes gLMs and sequence-to-fu…
europepmc
2026
置信度 0.80
-
An array of four independently wired indium tin oxide (ITO) electrodes was used for electrochemically stimulated DNA release and activation of DNA-based Identity, AND and XOR logic gates. Single-stranded DNA molecules were loaded on the mixed poly( N , N -di-m…
europepmc
2017
置信度 0.80
-
Programmed DNA self-assembly, based on branched DNA structures, provides a general approach for constructing defined nanostructures for drug delivery, biosensing, nanofabrication, and information processing and storage. Three-arm DNA junctions (3aJs), the simp…
europepmc
2026
置信度 0.80
-
Motivation DNA storage offers exceptional information density and archival longevity but is constrained by complex biochemical noise inherent to synthesis, storage, and sequencing. Conventional hard-decision error-correction schemes often rely on excessive red…
europepmc
2026
置信度 0.80
-
MicroRNAs (miRNAs) have emerged as potential biomarkers for human diseases. Classification models established on the expression levels of multiple miRNAs can be used to realize a reliable diagnosis of diseases. The detection of expression patterns of multiple …
europepmc
2026
置信度 0.80
-
Genetic variants in the DNA polymerase enzymes POLE and POLD1 can affect protein function by altering stability, catalysis, DNA binding, and interactions with other biomolecules. Understanding the structural basis of these variants is important for a comprehen…
europepmc
2026
置信度 0.80
-
DNA Computing is a rapidly-developing interdisciplinary area which could benefit from more experimental results to solve practical problems with the current biological tools. In this study, we have integrated microelectronics and molecular biology techniques f…
europepmc
2011
置信度 0.80
-
The interplay between transcription factors (TFs) and nucleosomes is central to gene regulation, yet most studies adopt a protein-centric perspective that largely overlooks DNA sequence contributions. Here, we identify four distinct nucleosomal DNA classes, in…
europepmc
2026
置信度 0.80
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The European anchovy is a keystone forage species in the Mediterranean and Northeast Atlantic, yet a chromosome-scale reference genome has been lacking. Here, we present a 1.4 Gb assembly anchored to 24 chromosomes (scaffold N50 = 56.4 Mb; BUSCO 96.6%) with 27…
europepmc
2026
置信度 0.80
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Tailoring the properties of 2D materials through precise control of both local arrangement and long-range order on surfaces remains a central challenge in materials science. While surface-assisted assembly of symmetric, non-interacting DNA origami nanostructur…
europepmc
2026
置信度 0.80
-
DNA origami enables the programmable self-assembly of nucleic acids into precisely defined nanostructures, yet the influence of primary base sequence on folding reliability remains incompletely understood. In particular, off-target interactions between scaffol…
europepmc
2026
置信度 0.80
-
The widespread use of high-resolution remote sensing images in meteorology, geology, and national security calls for highly efficient and secure protection mechanisms. However, conventional image encryption methods often face substantial limitations when handl…
europepmc
2026
置信度 0.80
-
DNA offers exceptional information density and stability, making it a promising medium for long-term data storage. However, the high cost of DNA synthesis and data retrieval remain key barriers to large-scale deployment. In this paper, we present DNA staples, …
europepmc
2026
置信度 0.80
-
Background Neoadjuvant chemoradiotherapy (nCRT) is the standard treatment for locally advanced rectal cancer (LARC), yet clinically validated biomarkers for predicting response remain lacking. This study aimed to identify candidate molecular events associated …
europepmc
2026
置信度 0.80
-
DNA-based Boolean logic gates represent a transformative platform in molecular computation, providing a bridge between biological processes. The field has advanced toward sophisticated designs incorporating spatiotemporal control. Distinguished by features suc…
europepmc
2026
置信度 0.80
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Biomolecular reservoir computing, despite its potential for nontraditional information processing, encounters difficulties in realizing intricate nonlinear dynamics within biochemical systems. This research proposes a biomolecular reservoir computing framework…
europepmc
2026
置信度 0.80
-
Copy number signatures provide compact representations of the processes that shape cancer genomes, but signatures derived with different feature encodings are often interpreted as if they were interchangeable. We established a matched-sample pan-cancer benchma…
europepmc
2026
置信度 0.80
-
DNA has emerged as a versatile molecular engineering material owing to its predictable base-pairing rules, structural programmability, and excellent biocompatibility. Programmable DNA logic systems capable of integrating diverse biological signals and execute …
europepmc
2026
置信度 0.80
-
Background The continually increasing volume of sequence data results in a growing demand for fast implementations of core algorithms. Computation of pairwise alignments based on dynamic programming is an important part in many bioinformatics pipelines and a m…
europepmc
2025
置信度 0.80
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[This corrects the article DOI: 10.1016/j.fmre.2023.06.015.].
europepmc
2026
置信度 0.80
-
In this paper, we use an adapted multi-objective version of the differential evolution (DE) metaheuristics for the design and generation of reliable DNA libraries that can be used for computation. DNA sequence design is a very relevant task in many recent rese…
europepmc
2014
置信度 0.80
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Molecular logic devices with various functions play an indispensable role in molecular data transmission/processing. However, during any kinds of data transmission, a constant and unavoidable circumstance is the appearance of bit errors, which have serious eff…
europepmc
2017
置信度 0.80
-
Protein-DNA complexes are involved in vital cellular functions such as gene regulation, replication, transcription, packaging, rearrangement, and damage repair. In this work, we proposed an intricate streamlined geometric formalism for computing the absolute b…
europepmc
2026
置信度 0.80
-
Background Building on primary data generated by its member consortia, the International Human Epigenome Consortium has uniformly processed a collection of more than 2,000 reference epigenomes profiling histone modifications, DNA methylation, and RNA expressio…
europepmc
2026
置信度 0.80
-
The rapid growth of digital communication and large-scale data exchange has increased the demand for advanced cryptographic techniques capable of resisting emerging computational threats. Conventional encryption methods primarily rely on mathematical complexit…
europepmc
2026
置信度 0.80
-
MicroRNAs (miRNAs) serve as crucial biomarkers in disease diagnosis. Although silicon-based electronic machine learning models provide efficient means for analyzing the massive data associated with miRNAs and for disease diagnosis, they remain constrained by l…
europepmc
2026
置信度 0.80
-
The scaling limits of conventional electronics necessitate a shift toward alternative physical computing substrates. We present a universal logic design based on a novel materials platform employing FRET-coupled Fluorescent Protein (FP) NOR gates. By leveragin…
europepmc
2026
置信度 0.80
-
One of the key events in the HIV-1 life cycle is reverse transcription, during which single-stranded viral RNA (ssRNA) is converted into double-stranded DNA (dsDNA). This process occurs inside the mature virus capsid and, once it reaches a critical threshold, …
europepmc
2026
置信度 0.80
-
Background Mediation analysis of high-dimensional features, particularly molecular-level omics features, provides important opportunities to uncover biological mechanisms underlying human health and disease. However, two central statistical challenges remain: …
europepmc
2026
置信度 0.80
-
Game theory provides an architecture for multi-agent strategic interactions, while DNA computing offers programmable, parallel molecular-scale operations, enabling unique "molecular gaming" systems beyond silicon-based architectures. Current approaches, primar…
europepmc
2026
置信度 0.80
-
DNA damage and epigenetic regulation are early biological processes that may reflect metabolic, inflammatory, hematological, and environmental influences during childhood, yet data integrating comet assay parameters, global DNA methylation, and clinical or exp…
europepmc
2026
置信度 0.80
-
Background Differentially methylated regions (DMRs) are essential regulatory features for characterizing epigenetic variation, understanding population-level differences, and interpreting haplotype-specific methylation patterns. However, existing DMR detection…
europepmc
2026
置信度 0.80
-
Toehold-mediated strand displacement (TMSD) is essential for dynamic DNA nanotechnology but often suffers from slow kinetics and nonspecific leakage, limiting efficient logic systems. To address this, we propose an anchorhold-actuated strand migration (AASM) s…
europepmc
2026
置信度 0.80
-
The solution space exponential explosion caused by the enumeration of the candidate solutions maybe is the biggest obstacle in DNA computing. In the paper, a new unenumerative DNA computing model for graph vertex coloring problem is presented based on two tech…
europepmc
2011
置信度 0.80
-
Summary Local opening of the DNA double helix is required in many fundamental biological processes and is, in part, controlled by the degree of superhelicity imposed in vivo by the protein machinery. In particular, positions of superhelically destabilized regi…
europepmc
2013
置信度 0.80
-
Next-generation sequencing (NGS) technology has revolutionized forensic DNA analysis by increasing sensitivity to detect low amounts of DNA, expanding throughput capacity, allowing multiplexed marker panels, and improving sequencing resolution. However, the di…
europepmc
2026
置信度 0.80
-
Chemical and physical computing systems promise information processing in performance regimes inaccessible to conventional electronics. However, they are typically constrained by static hardware architectures that limit adaptability and computational richness.…
europepmc
2026
置信度 0.80
-
Motivation High-fidelity simulation of nanopore sequencing signals is critical for rigorous benchmarking and validation of the nanopore signal processing pipeline. However, existing signal simulators often fail to capture the non-linear dynamics of nanopore cu…
europepmc
2026
置信度 0.80
-
openalex
Luca Cardelli
2009-01-01
置信度 0.72
DNA computingProcess calculusTheory of computationComputer scienceAlgebra over a field
-
openalex
Olgica Milenković, Navin Kashyap
2006-01-01
置信度 0.72
Computer scienceDNA computingNucleic acid secondary structureCode wordHadamard transform
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openalex
Michael J. Geisow, A. N. Barrett
1983-01-01
置信度 0.72
Computer science
-
openalex
Gheorghe Pǎun
2000-08-01
置信度 0.72
Recursively enumerable languageMembrane computingVenn diagramComputabilityObject (grammar)
-
openalex
2005-03-01
置信度 0.72
Computer science
-
A new conceptual framework and a minimization principle together provide an understanding of computation in model neural circuits. The circuits consist of nonlinear graded-response model neurons organized into networks with effectively symmetric synaptic conne…
openalex
J. J. Hopfield, David W. Tank
1986-08-08
置信度 0.72
Electronic circuitComputer scienceBiological neural networkComputationNonlinear system
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We discovered an empirical relationship between the logarithm of mean excitation energy (ln Im) and the effective atomic number (EAN) of human tissues, which allows for computing patient-specific proton stopping power ratios (SPRs) using dual-energy CT (DECT) …
openalex
Ming Yang, G. F. Virshup, James E. Clayton, Xiangrong Zhu 等
2010-02-10
置信度 0.72
Digital Enhanced Cordless TelecommunicationsHounsfield scaleEffective atomic numberCalibrationNuclear medicine
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openalex
Zhongrui Wang, Saumil Joshi, Sergey Savel’ev, Hao Jiang 等
2016-09-26
置信度 0.72
Neuromorphic engineeringMemristorMaterials scienceNanotechnologySynaptic plasticity
-
openalex
Fabian Isensee, Paul F. Jaeger, Simon A. A. Kohl, Jens Petersen 等
2020-12-07
置信度 0.72
Computer scienceSegmentationArtificial intelligenceRendering (computer graphics)Image segmentation
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BACKGROUND: Scientists have long been driven by the desire to describe, organize, classify, and compare objects using taxonomies and/or ontologies. In contrast to biology, geology, and many other scientific disciplines, the world of chemistry still lacks a sta…
openalex
Yannick Djoumbou-Feunang, Roman Eisner, Craig Knox, Leonid Chepelev 等
2016-11-04
置信度 0.72
Computer scienceTaxonomy (biology)Class (philosophy)DruggabilityInformation retrieval
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We demonstrate the additive manufacturing of complex three-dimensional (3D) biological structures using soft protein and polysaccharide hydrogels that are challenging or impossible to create using traditional fabrication approaches. These structures are built …
openalex
Thomas J. Hinton, Quentin Jallerat, Rachelle N. Palchesko, Joon Hyung Park 等
2015-10-02
置信度 0.72
Self-healing hydrogels3D printingEmbeddingBiocompatible material3d printed