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• From Symbolic Trauma to Psychosomatic Healing: Second Brain Psychology between Neuroscience and Clinical Narrative
  Second Brain Psychology (SBP) is a dynamic psychological model that integrates neuroscience, symbolism, biology, and clinical experience to understand and transform emotional and psychosomatic disorders. Centered on the recognition of the enteric nervous syste…
  preprints 2025 置信度 0.74
• Human and AI voice identities evoke shared neural signatures during speaker recognition across changes in speech content and prosody
  Both biologically-produced human voices and algorithmically-generated AI speech manifest speaker identity. Critically, prosodic variations modulate the acoustic dimensions (e.g., fundamental frequency) that also shape individual speaker identity representation…
  preprints 2025 置信度 0.74
• Suicide and the Survival Architecture of Coping: A Model of Arousal Regulation from Contemplation to Collapse
  The Survival Architecture of Coping (SArC) reframes the concept of suicide not as a failure of will or morality, but as the terminal phase of an overwhelmed regulatory system. Drawing from affective neuroscience, developmental psychology, and contemporary suic…
  preprints 2025 置信度 0.74
• Open-source C++ Framework of Nonnegative Matrix Factorization and its applications in neuroimaging
  Non-negative matrix factorization (NMF) produces a factorization that constrains the elements of both the factor matrices to be non-negative. It has been a popular feature extraction method in many applications including neuroimaging. One limitation of the exi…
  preprints 2025 置信度 0.74
• Critical review on the development and evolution of beat perception
  Beat perception—the ability to extract a regular pulse from rhythmic sequences—is a foundational component of human musicality and a key mechanism supporting synchronization, dance, and collective music-making. Research across neuroscience, developmental psych…
  preprints 2025 置信度 0.74
• Effects of Spatial Attention on Visuocortical Processing: A Multi-Laboratory Replication of Clark & Hillyard (1996)
  Whether selective attention alters initial sensory processing or instead only operates at higher cortical stages (often referred to as early vs. late selection) is a foundational question in cognitive neuroscience. Investigating the influence of covert visual …
  preprints 2025 置信度 0.74
• Effect of fluid control on the affective state of laboratory macaques
  Fluid control protocols are widely used in neuroscience to motivate laboratory macaques to engage with behavioural tasks. Despite strong evidence that the physiology of the animals is not compromised by such protocols, fluid control remains controversial due t…
  preprints 2025 置信度 0.74
• Barriers and Facilitators to the Implementation of Virtual Reality as a Pain Management Intervention in Outpatient Physiotherapy Practices: A Qualitative Analysis
  Abstract Background Chronic pain is a leading global cause of disability. There is evidence supporting the efficacy of virtual reality (VR) interventions for improving pain and function in patients with chronic pain. However, use of VR in physiotherapy practic…
  preprints 2025 置信度 0.74
• SpineDL: a Deep Learning-based approach for neuron and anatomical structure segmentation in immunofluorescence images of damaged spinal cords
  In this study, we present SpineDL, an open-source deep learning (DL) approach for neurons and anatomical structure segmentation of the spinal cord in fluorescence images immunostained with NeuN and DAPI, within the context of murine models of spinal cord injur…
  preprints 2025 置信度 0.74
• Consciousness as 4-Manifold Painlevé V Dynamics: From Quantum Topology to Classical Gamma Oscillations
  We propose a novel mathematical framework for understanding conscious experience based on the topology of 4-manifolds and the theory of Painlevé transcendents, with deep connections to quantum field theory and topological quantum field theory (TQFT). We conjec…
  preprints 2025 置信度 0.74
• An integrated single-cell transcriptomic dataset for Mouse cortex
  Abstract As the central functional hub of the central nervous system, the cerebral cortex has long been a major frontier in neuroscience research. With the increasing maturity and widespread application of single-cell RNA sequencing technologies, multiple stud…
  preprints 2025 置信度 0.74
• NeuroSense: A Computational AI Model for Continuous Psychological State Prediction
  An emerging interdisciplinary challenge in artificial intelligence, computational psychology, and neuroscience is the ongoing evaluation of human psychological states. Conventional mental-state assessments rely on clinical interviews and episodic, subjective s…
  preprints 2025 置信度 0.74
• Spectrogram Contrast Enhancement Improves EEG Signal-Based Emotional Classification
  Neuroscience adopts a multidimensional approach to decode thoughts and actions originating inside the brain, aka the Brain Computer Interface (BCI). However, achieving high accuracy in these decodings remains a challenge and an open research topic in BCI resea…
  preprints 2025 置信度 0.74
• A reference brain for the clonal raider ant
  ABSTRACT Ants exhibit remarkable collective and social behaviors, such as alloparental care 1 , chemical communication 2 , homing 3 , and cooperative group hygiene 4 . The clonal raider ant Ooceraea biroi is especially well-suited for investigating the neurona…
  preprints 2025 置信度 0.74
• FDTest: Fluctuation-Dissipation Theorem as a Test for Memory Effects in Brain Dynamics
  A central challenge in neuroscience is to understand how the brain flexibly balances local and distributed information processing to support diverse cognitive and conscious states. We hypothesize that a key signature of this balance is the presence of memory e…
  preprints 2025 置信度 0.74
• From labels to latents: revealing state-dependent hippocampal computations with Jump Latent Variable Model
  Neural activity is usually interpreted by imposing external labels (e.g., stimuli or position during locomotion) and decoding within that space (e.g. replay). While powerful, such supervision can mask structure in the data that do not correspond to the label. …
  preprints 2025 置信度 0.74
• GenBrain: A Generative Foundation Model of Multimodal Brain Imaging
  Neuroimaging faces a reproducibility crisis, where studies on small, heterogeneous datasets produce unreliable brain-wide associations and AI models that fail to generalize. To address this, we introduce GenBrain, a generative foundation model pretrained on ap…
  europepmc 2025 置信度 0.80
• Robust circular cluster-based statistics for respiration-brain coupling
  The rapidly developing research field of brain-body neuroscience faces methodological challenges, as analysts continue to develop new analysis strategies for robust statistics in the absence of established best practices. This quest for robust statistics is fu…
  preprints 2025 置信度 0.74
• Critical review on the development and evolution of beat perception
  Beat perception—the ability to extract a regular pulse from rhythmic sequences—is a foundational component of human musicality and a key mechanism supporting synchronization, dance, and collective music-making. Research across neuroscience, developmental psych…
  preprints 2025 置信度 0.74
• Revamping neuroimaging analysis to reveal biomarkers of adolescent mental health
  Advances in neuroscience research provide an unprecedented opportunity to identify the etiopathogenesis of mental health disorders. Yet, it has proven difficult to find reliable associations between neurobiological phenotypes and real-world mental health exper…
  preprints 2025 置信度 0.74
• Improving autobiographical episodic memory, quality of life, and sense of self with a smartphone intervention in early dementia: A case study
  In memory disorders such as Alzheimer’s disease, recent autobiographical memories are disproportionately vulnerable to loss, yet most traditional reminiscence therapies focus on remote past events. We present a case study examining whether a digital reminiscen…
  preprints 2025 置信度 0.74
• The Proximal Chemical Mandate Principle: A Framework for Invariant Biological Dynamic Optimization
  This paper presents the Proximal Chemical Mandate Principle, a theoretical framework proposing that behavior in organisms with neurochemical systems is governed by two invariant mandates: reward signal maximization (R↑) and stress signal minimization (S↓). We …
  preprints 2025 置信度 0.74
• livn: A testbed for learning to interact with in vitro neural networks
  A bstract The investigation of cultured biological neural networks is a critical frontier in neuroscience with profound implications for the advancement of brain-machine interfaces, treatments of neurological diseases, and fundamental insights into neural comp…
  preprints 2025 置信度 0.74
• Reassessment of the Hippocampal Index Theory: A Synopsis of the Present Evidence and Computational Models
  The connection between how memory is represented in the brain and how it can be computationally modeled lies at the heart of contemporary neuroscience. This review revisits the Hippocampal Index Theory in light of recent studies to investigate the structural a…
  preprints 2025 置信度 0.74
• Classifying Calcium Imaging Dynamics with Deep Learning: Multi-Frequency Analysis through Quantile-Based Time-Series Network Representations
  To address the limitations of calcium imaging data, we propose a segmentation-agnostic deep learning framework that integrates Quantile-Based Time-Series Network (QTN) representations with convolutional neural networks to classify neuronal dynamics across mult…
  preprints 2025 置信度 0.74
• How physical information is used to make sense of the psychological world
  Across the cognitive sciences, researchers have studied theory of mind (making sense of other people’s behaviors in terms of their mental states, or ‘naive psychology’) and physical reasoning (making sense of physical events in terms of their underlying mechan…
  preprints 2025 置信度 0.74
• Sequence-Independent RNA Sensing in Living Mammalian Cells
  Recently, several groups described sensors in living cells that take advantage of adenosine deaminases acting on RNA (ADARs) to link the presence of an RNA (a "target transcript") to the translation of a payload from a second, exogenously introduced mRNA. Thes…
  preprints 2025 置信度 0.74
• Split-trial analysis reveals the information capacity of neural population codes
  Understanding how correlated neural noise affects neural population coding is a basic question in computational and systems neuroscience [1, 2, 3, 4]. Recent theoretical work suggests that shared noise along the stimulus encoding direction is the primary facto…
  preprints 2025 置信度 0.74
• From Ions to Chaos: exploring a whole-brain modelling framework in the mouse
  Computational neuroscience offers powerful tools for understanding brain function in both healthy and diseased states. However, detailed data on microscale mechanisms—such as those involved in genetics and pharmacology—are often derived from mouse experiments …
  preprints 2025 置信度 0.74
• Somatosensory-Driven Perception in Embodied Systems for Hand-Object Interaction
  Abstract Somatosensation is a powerful perceptual modality that enables accurate and robust sensing in challenging scenarios. It allows blind individuals to explore their surroundings with a white cane in darkness and assists surgeons who operate with a scalpe…
  preprints 2025 置信度 0.74
• Curvature-based machine learning method for automated segmentation of dendritic spines
  A bstract Recent advances in connectomics have been led by high-resolution reconstruction of large volumes of neural tissues using electron microscopy (EM), providing unprecedented insights into brain structure and function. Dendritic spines—dynamic protrusion…
  preprints 2025 置信度 0.74
• Uznadze’s Theory of Set: Experimental Diagnostics and Neurocognitive Implications
  The paradigm of set, developed by the Georgian psychologist D.N. Uznadze, represents a foundational contribution to the science of non-conscious behavioral regulation. This preprint provides a comprehensive analysis of the set phenomenon, revisiting its core p…
  preprints 2025 置信度 0.74
• Low-Frequency Textured Gabor Flicker Enhances Neural Entrainment and Visual Comfort for Brain-Computer Interface Control
  Steady-state visual evoked potentials (SSVEPs) are widely used in cognitive neuroscience and brain–computer interfaces (BCIs), but the visual discomfort induced by repetitive luminance flicker limits their usability, particularly in multi-target settings due t…
  preprints 2025 置信度 0.74
• A neural network with key-value episodic memory retrieves and organizes memories based on causal event structures
  Humans reflect on memories to make sense of ongoing events. Past work has shown that people retrieve causally related memories during comprehension, but the mechanisms underlying this process remain unclear. Here, we used a recurrent neural network augmented w…
  preprints 2025 置信度 0.74
• <i>Drosophila</i> maintain a consistent navigational goal angle for days to weeks
  Past work has demonstrated that Drosophila can keep to a consistent navigational bearing for minutes to hours. Here, we ask whether they can do so over days to weeks. First, we describe an experimental rig that allows individual head-fixed Drosophila to live f…
  preprints 2025 置信度 0.74
• The Theory of the Origin of Life by Li Huo
  The origin of life is a core proposition in natural science, while the nature of consciousness has long been outside the empirical framework due to the "mystification misunderstanding". Together, they constitute the ultimate pursuit of human civilization. This…
  preprints 2025 置信度 0.74
• Cellular deconvolution of the brain with topological magnetic resonance image analysis
  Magnetic resonance imaging (MRI) is foundational tool in neuroscience, enabling characterization of neuroanatomical markers of disease, behavior, and cognition. However, the precise cellular processes driving the structural and functional readouts provided by …
  preprints 2025 置信度 0.74
• Disentangling Within- and Between-Subject Correlations in Cognitive Models: The Essential Role of Hierarchical Estimation
  Cognitive models, such as evidence-accumulation models, are increasingly used in individual differences research in psychology and neuroscience. By computing correlations between cognitive model parameters across participants, researchers aim to understand how…
  preprints 2025 置信度 0.74
• Cultural Quantum Cognition and Decision
  Recent advances in cultural psychology elucidated a number of cultural differences in diverse psychological characteristics and behaviors from perceptions, and economic decisions to religiosity. Also, quantum models of cognition and decision making have been d…
  preprints 2025 置信度 0.74
• Advances in Brain Imaging Technologies: A Comprehensive Overview
  Advances in brain imaging technology have significantly enhanced the diagnosis and understanding of neurological disorders. This study explores the clinical roles and advancements of five key brain imaging modalities: functional Magnetic Resonance Imaging (fMR…
  europepmc 2025 置信度 0.80
• Rethinking Emotion as Part of the Arousal Appraisal Model
  The Arousal Appraisal Model (AAM) is proposed as a theoretical framework in which emotion is understood as one phase in a broader process of arousal regulation. In this account, low-load contemplation, matched-load action, excess-load emotion, and overload col…
  preprints 2025 置信度 0.74
• Selective engagement of the primate orbitofrontal cortex during value-based but not perceptual decisions
  A fundamental question in neuroscience is whether the brain uses specialized sub-systems for different types of decisions or relies on a unified decision-making network. The orbitofrontal cortex (OFC) provides an ideal test case for this question: it has a wel…
  preprints 2025 置信度 0.74
• Crombie, Hacking and the Emergence of Two New Styles: Data-Intensive and Network-Relational Reasoning
  The classical taxonomy of Western scientific styles introduced by Crombie and reinterpreted by Hacking has framed how historians and philosophers understand the plurality of scientific reasoning. Yet contemporary scientific practice has expanded beyond the six…
  preprints 2025 置信度 0.74
• Decoding with multivariate pattern analysis is superior for optically pumped magnetometer-based magnetoencephalography compared to superconducting quantum interference device-based systems
  Background Multivariate pattern analysis (MVPA) has become an increasingly important method for decoding distributed brain activity from neural electrophysiological recordings by leveraging both temporal and spatial features. These multivariate approaches have…
  preprints 2025 置信度 0.74
• Distinguishing agency and subjectivity in anesthesia: a review and synthesis of neural and theoretical perspectives across scales
  Anesthesia research has identified cellular and systems-level changes underlying loss of consciousness, yet these findings remain largely disconnected. Variations in conscious states, such as anesthesia awareness, highlight the distinction between observable r…
  preprints 2025 置信度 0.74
• Stacked Domain Learning: A structured framework for integrating disciplinary perspectives through predictive modeling
  Large-scale studies increasingly collect data across multiple disciplines such as neuroscience, psychology, and genetics. Combining these data offers new opportunities for understanding human behavior, but it also presents substantial analytical challenges. Tr…
  preprints 2025 置信度 0.74
• Dissecting the strain and sex specific connectome signatures of unanesthetized C57BL/6J and DBA/2J mice using magnetic resonance imaging
  Mouse models are an essential tool for understanding behavior and disease states in neuroscience research. While genetic and sex-specific effects have been reported in many neurodegenerative and psychiatric illnesses, these factors may also alter baseline neur…
  preprints 2025 置信度 0.74
• Trade-off between performance and human-like perception in face recognition models
  In the past decade, different computational models have been developed for face recognition. Despite their widespread use in cognitive neuroscience studies, it is not well understood whether their excellent recognition performance means that they “see” faces l…
  preprints 2025 置信度 0.74
• Improved Estimation of Correlation Accuracy for Machine Learning Brain-Phenotype Associations
  Machine learning is used in neuroscience to examine brain-phenotype associations and facilitate individual prediction from high-dimensional brain imaging. For continuous phenotypes, Pearson correlation between the observed and predicted phenotype is used to qu…
  preprints 2025 置信度 0.74
• Longitudinal brain structural changes during clozapine treatment: associations with neuroreceptor architecture and clinical response
  In treatment-resistant schizophrenia, clozapine treatment has been associated with longitudinal reductions in subcortical volumes, ventricular enlargement, and widespread cortical thinning. However, it is unknown how these structural changes relate to clozapin…
  preprints 2026 置信度 0.74
• Deep-Pose-Tracker: an automated behavioural analysis framework for <i>Caenorhabditis elegans</i>
  Tracking and analyzing animal behaviour is a crucial step in fields such as neuroscience and developmental biology. Behavioural studies in the nematode C. elegans , for example, help in understanding how organisms respond to external cues and how the specific …
  preprints 2025 置信度 0.74
• Beyond correlations: causally linking neural circuits and consciousness in rodents
  Research into the neural mechanisms of consciousness has so far mainly progressed through human neuroscience. However, most of the available techniques for use in human subjects lack the ability to probe the underlying neuron- and circuit-level mechanisms. Ani…
  preprints 2025 置信度 0.74
• Computational Modeling of Transcranial Electric Stimulation in Anemic Conditions: A Hodgkin-Huxley and Finite Element Analysis
  Abstract Computational models of tES typically assume normal physiological conditions. The effect of systemic metabolic disorders like anemia on tES efficacy remains unexplored. This study investigates the effects of transcranial electric stimulation (tES) on …
  preprints 2025 置信度 0.74
• Overcoming Catastrophic Interference: Neuroscience-inspired Models for Continuous Learning in Neural Networks
  Catastrophic interference (a.k.a. catastrophic forgetting) occurs when neural networks suddenly lose previously learned knowledge while acquiring new information. However, the human and animal brain have evolved several mechanisms to solve this problem. In thi…
  preprints 2025 置信度 0.74
• Binocular vision emerges from the coordinated development of orbit convergence, eye orientation, and high-acuity retinal specializations
  Binocular vision requires both eyes to be aligned such that their visual fields overlap. A long-standing premise derived from comparative studies is that the orientation of the orbits determines eye position, and thereby the extension of this overlap, the bino…
  preprints 2025 置信度 0.74
• SynAnno: Interactive Guided Proofreading of Synaptic Annotations
  Connectomics, a subfield of neuroscience, aims to map and analyze synapse-level wiring diagrams of the nervous system. While recent advances in deep learning have accelerated automated neuron and synapse segmentation, reconstructing accurate connectomes still …
  preprints 2025 置信度 0.74
• Motor circuits prioritizing safety-seeking
  crossref Ole Kiehn 2025-08-06T20:13:47Z 置信度 0.70
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• Deep Brain stimulation in Africa
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  crossref 2025-09-30T10:24:21Z 置信度 0.70
• Leveraging transparent ontology learning to refine constructs in neuroscience
  crossref David Moreau, Kristina Wiebels 2025-04-01T11:10:16Z 置信度 0.70
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• Philippe Ascher: My recollections
  Philippe Ascher remains a true hero of mine.I cannot recall when I first met him.However, I first became aware of him with his Nature paper in 1970 with Jacsue Kehoe (Kehoe and Ascher, 1970).I had just returned to NIH following a stressful medical internship a…
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• Explainability and Interpretability in the neurosciences
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• Correction to “The History of Danish Neuroscience”
  Paulson, O.B., Schousboe, A. and Hultborn, H. (2023), The History of Danish Neuroscience. European Journal of Neuroscience, 58: 2893–2960. https://doi.org/10.1111/ejn.16062. In the paper by Paulson et al. (2023), there was an error in the legend for Figure 1. …
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