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Brain disorders remain one of the greatest challenges in neuroscience. Computational precision medicine offers a promising framework to reveal the mechanistic principles governing both healthy and pathological brain dynamics. In this context, we present The Tu…
preprints
2025
置信度 0.74
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Significance Behavior scoring is labor-intensive and subjective, introducing variability in results. Large Language Models (LLMs) capable of video understanding offer a transformative solution to manual scoring, crucial for accelerating and standardizing neuro…
preprints
2025
置信度 0.74
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Abstract The phenomenon of only 1% to 5% neuronal staining using the Golgi staining method, a technique related to the 1906 Nobel Prize in Physiology or Medicine, has plagued the neuroscience community for a hundred years. This article is based on the original…
preprints
2025
置信度 0.74
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Objective Sleep health and depression are interconnected multidimensional constructs, yet their shared determinants remain obscure. Understanding the role of socioeconomic/lifestyle factors in predicting sleep-related depression (SRD) is critical for preventiv…
preprints
2026
置信度 0.74
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Abstract High-density, long-term stable decoding of whole-brain function is crucial for advancing basic neuroscience research and developing neural disorder therapies. However, two major challenges remain: the lack of scalable interfaces capable of long-term, …
preprints
2025
置信度 0.74
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Fearful-expression recognition is critical for adaptive responses to potential threats and relies on both rapid threat detection and fine-grained face encoding. Yet how human amygdala subregions differentially support these distinct cognitive components remain…
preprints
2025
置信度 0.74
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In this paper, we present Radical Embodied Memory (REM), a new theory of memory grounded in thecommitments and concepts of radical embodiment. First, we distinguish between the conceptualfoundations of mainstream cognitive neuroscience and radical embodied cog…
preprints
2025
置信度 0.74
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The rapid expansion of biological and computational datasets demands scalable methods that support both visualization and quantitative interpretation. Hyperbolic embeddings are well suited to represent hierarchical structure, but existing approaches are limite…
preprints
2025
置信度 0.74
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Personalized brain modeling at clinically relevant scales requires integrating biophysical models with empirical neuroimaging data, yet high-dimensional parameter estimation in whole-brain network models remains computationally prohibitive. We present TVB-Opti…
preprints
2025
置信度 0.74
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Background Complex spikes (CSs) in cerebellar Purkinje cells convey unique signals complementary to Simple spike (SS) action potentials, but are infrequent and variable in waveform. Their variability and low spike counts, combined with recording artifacts such…
preprints
2025
置信度 0.74
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SUMMARY Alzheimer’s disease (AD) research has been hindered by the lack of models that faithfully recapitulate the full profile of disease progression in a human genetic background. We developed a 3D assembloid model (“Masteroid”) using iPSC-derived neurons, a…
preprints
2025
置信度 0.74
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Pathogenic variants in SLC6A1 , which encodes GABA Transporter 1 (GAT-1), are associated with developmental delay, autism, epilepsy (e.g., epilepsy with myoclonic astatic seizures [EMAS]), and possibly schizophrenia. Functional assays to establish pathogenicit…
preprints
2025
置信度 0.74
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The Cambridge Centre for Ageing and Neuroscience (Cam‐CAN, www.cam‐can.org) was established 15 years ago to investigate the cognitive and brain bases of healthy adult ageing. Data from its first three stages were shared with other researchers around the world,…
preprints
2025
置信度 0.74
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Nematodes communicate via diverse sex pheromones, including long-range volatile signals, short-range chemical cues, and contact-dependent molecules. While the ascaroside family of small molecules that mediate short-range attraction is well characterized, the i…
preprints
2025
置信度 0.74
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This work explores a unified metaphysical and mathematical framework for causality, perception, and observer-based reality, bridging foundational insights from physics and neuroscience. A central thesis is the modeling of conscious observers as Dirac delta fun…
preprints
2025
置信度 0.74
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The alignment between neural dynamics and environmental structures constitutes a fundamental challenge in neuroscience. While Georg Northoff's Temporo-Spatial Theory of Consciousness (TTC) posits a "common currency" of temporo-spatial dynamics, the mechanistic…
preprints
2026
置信度 0.74
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ABSTRACT The brain is the main controller of animal behaviors. During the speciation process, divergent behaviors can arise between new sibling species. However, the comprehensive molecular changes in the brain that give rise to these emergent behavioral diffe…
preprints
2026
置信度 0.74
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Understanding how the brain represents information is a central challenge in neuroscience and a practical bottleneck for brain-computer interfaces. Existing analytical tools cannot identify neural representations directly from neural activity data. We introduc…
preprints
2025
置信度 0.74
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Immanuel Kant's Critique of Pure Reason has profoundly influenced numerous fields, including neuroscience. His explorations of human cognition, perception, and the limitations of knowledge offer foundational insights that resonate with contemporary neuroscient…
preprints
2025
置信度 0.74
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Background: /Objectives: Intermittent fasting (IF) has been widely investigated for its metabolic effects, including improvements in insulin sensitivity, lipid metabolism, and inflammatory markers. However, its psychological and experiential dimensions remain …
preprints
2026
置信度 0.74
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Affect-based impulsivity describes the tendency to behave impulsively while experiencing negative or positive affective states. In the context of psychiatric disorders, the consequences of affect-based impulsivity can be dire, including suicidal behavior and h…
preprints
2025
置信度 0.74
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Increased attention to racial inequities catalyzed a surge in publications documenting racial biases in neuroscience with one recent article in Nature Neuroscience effectively drawing attention to how skin conductance response is less reliably detected for Bla…
preprints
2025
置信度 0.74
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Educational neuroscience is rapidly reshaping how we think about learning. However, its promise will remain unrealised without an inclusive and ethical lens. This conceptual article positions neuroscience as a catalyst for re-imagining schooling that honours t…
preprints
2025
置信度 0.74
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Neuroscience-inspired neural networks bridge biology and technology, offering powerful tools to model brain function while enabling adaptive, efficient control in robotics. In this work, we present a neuroscience-inspired synaptic learning rule based on the sy…
preprints
2025
置信度 0.74
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Increased attention to racial inequities catalyzed a surge in publications documenting racial biases in neuroscience with one recent article in Nature Neuroscience effectively drawing attention to how skin conductance response is less reliably detected for Bla…
preprints
2025
置信度 0.74
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SUMMARY Advances in neuroscience and gene therapy would be greatly accelerated by adeno-associated virus (AAV) vectors capable of crossing the blood–brain barrier (BBB). Unfortunately, capsids evolved in mice often fail to function in other species, limiting a…
preprints
2025
置信度 0.74
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Functional near-infrared spectroscopy (fNIRS) is a portable, non-invasive neuroimaging technique that is well-suited for project-based undergraduate neuroscience research methods courses. In this paper, we first explain the basic principles of fNIRS including …
preprints
2025
置信度 0.74
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The global proliferation of Mafia-type organizations stems not only from their capacity to intimidate and corrupt but also from cultural norms—such as the “code of silence”—that discourage citizens from cooperating with law enforcement and foster societal indi…
preprints
2025
置信度 0.74
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Background: Psychedelic-assisted therapies show promise for MDD, PTSD, and addiction, yet mechanisms are often framed as 5-HT2A-centric, despite evidence of GABAergic pathology in these conditions.Hypothesis (Author Perspective): As a chemist examining psyched…
preprints
2025
置信度 0.74
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Social anxiety disorder is among the most common forms of pediatric psychopathology. Social anxiety symptoms peak in adolescence and are associated with significant impairment encompassing familial, social, and academic domains. Considerable heterogeneity in s…
preprints
2025
置信度 0.74
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The ability to scan visual scenes to gather information is a critical adaptive skill across primates. The common marmoset, a small-bodied New World monkey and emerging model of social and visual neuroscience, relies heavily on rapid head movements in addition …
preprints
2025
置信度 0.74
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Background: Behavioral neuroscience experiments require precise stimulus control, millisecond timing, hardware integration, and robust data provenance. Increasing use of 3D environments and multimodal recordings adds challenges for development, accessibility, …
preprints
2025
置信度 0.74
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An exciting aspect of neuroscience is developing and testing hypotheses via experimentation. However, due to logistical and financial hurdles, the experiment and discovery component of neuroscience is generally lacking in classroom and outreach settings. To ad…
preprints
2025
置信度 0.74
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Epigenetic clocks are powerful biomarkers of biological aging, however, their performance varies across studies and contexts. Current limitations include siloed datasets, inconsistent validation methods, and the absence of a standardized framework for systemat…
preprints
2025
置信度 0.74
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Recent advances in the neuroscience of drug addiction motivates questions concerningwhether and how clinical practice may be based on or inspired by these new advances. In thischapter, we will provide a framework for summarizing novel, neuroscience-informed,co…
preprints
2025
置信度 0.74
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Motor signs have been central to descriptions of melancholia since antiquity, yet their significance and presumed causes have varied considerably across history. Until today and despite their robust link with worse outcomes, the origin of motor signs in mood d…
preprints
2025
置信度 0.74
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Background: Illicit drug use is an increasing global public health problem that causes significant neurological harm, psychiatric impairment, and decreased lifespan. Stimulants (e.g., cocaine, methamphetamine), psychoactive drugs (e.g., cannabis), and opioids …
preprints
2025
置信度 0.74
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Recent interdisciplinary advances have transformed the study of the evolution of music. Rather than treating music as a cultural artifact, current research targets musicality—the biological capacity enabling humans to perceive, produce, and enjoy structured so…
preprints
2025
置信度 0.74
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Recent interdisciplinary advances have transformed the study of the evolution of music. Rather than treating music as a cultural artifact, current research targets musicality—the biological capacity enabling humans to perceive, produce, and enjoy structured so…
preprints
2025
置信度 0.74
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Artificial Recurrent Neural Networks (RNNs) are widely used in neuroscience to model the collective activity of neurons during behavioral tasks. The high dimensionality of their parameter and activity spaces, however, often make it challenging to infer and int…
preprints
2025
置信度 0.74
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In a recent paper in Developmental Cognitive Neuroscience, Zablocki et al. (2025) propose Bayesian Regularized and Annotation-Informed Integrative Analysis of Cognition (BRAINIAC). A promising method that estimates the total variance explained by all features …
preprints
2025
置信度 0.74
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This article explores the future of urban environments, highlighting the need for inclusive design strategies to accommodate diverse populations, including those with age-related visual impairments and neurodiversity. It discusses the limitations of current st…
preprints
2025
置信度 0.74
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Abstract Background: Digital phenotyping involves the passive collection of behavioral and biometric data via smartphones and other personal devices. This emerging technology has the potential to transform outcome measurement in spine treatment by providing re…
preprints
2026
置信度 0.74
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Rapid learning is essential for flexible behavior, but its basis in the brain remains unknown. Here we introduce the PRISM plasticity rule, a unifying mechanistic model of three well-established, fast-acting synaptic plasticity rules---in hippocampus, cerebell…
preprints
2025
置信度 0.74
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Precision neuroimaging was used to explore specialization for verbal versus nonverbal processing. Consistent with prior findings, individuals exhibited a spatially left-lateralized association language network, with regions in both hemispheres robustly respond…
preprints
2025
置信度 0.74
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Cognitive neuroscience faces a measurement problem: core features of the human mind cannot be directly observed in the brain. For example, intentions are efficacious in behavior generation yet cannot be reduced to the sub-personal quantities of neural activity…
preprints
2025
置信度 0.74
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Humans can experience a rich array of conscious experience, including highly stable, positive, and refined states of non-ordinary perception that can be elicited through advanced meditation. Here, we present the first group-level, ultra-high-field (7T) fMRI st…
preprints
2025
置信度 0.74
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Network neuroscience provides a powerful framework for studying the mechanisms underlying brain-related diseases. As analyses become increasingly computational, ensuring their numerical reliability has become a critical challenge. Small perturbations introduce…
preprints
2025
置信度 0.74
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Understanding how cognition shapes behavior across contexts remains a fundamental challenge for many disciplines. In particular, for the optimism heuristic–i.e., the tendency to overweight positive (relative to negative) information–knowledge remains fragmente…
preprints
2025
置信度 0.74
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This philosophical essay explores the concept of "awakening" as a dynamic, non-permanent process by bridging ancient philosophy and modern neuroscience. It challenges the traditional view of a static, eternal nirvana by interpreting the human yearning for such…
preprints
2025
置信度 0.74
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Recent interdisciplinary advances have transformed the study of the evolution of music. Rather than treating music as a cultural artifact, current research targets musicality—the biological capacity enabling humans to perceive, produce, and enjoy structured so…
preprints
2025
置信度 0.74
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Language relies on a hierarchy of sensory and cognitive processes, yet how different levels of this hierarchy are supported by distinct neural architectures remains unclear. Here we show that semantic processing, compared with phonological processing, is assoc…
preprints
2026
置信度 0.74
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This study reviews the behavioral techniques that use the properties of visual stimuli to systematically control the activity of specific regions of an observer’s brain and proposes an Augmented Reality (AR) head-mounted display (HMD) that are implemented thes…
preprints
2025
置信度 0.74
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Eye tracking has been a popular behavioral recording method across psychology, neuroscience, and computer science, but a need for large and diverse datasets has emerged. Synthetic eye movement data offer a promising complement, yet it remains unclear which asp…
preprints
2025
置信度 0.74
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Activities with temporally distributed returns require deciding not only what to do, but when to stop. Although optimal foraging theory predicts that patch departure should depend on the total time invested in a patch, behavior across species often reflects se…
preprints
2025
置信度 0.74
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Beat perception—the ability to extract a regular pulse from rhythmic sequences—is a foundational component of human musicality and a key mechanism supporting synchronization, dance, and collective music-making. Research across neuroscience, developmental psych…
preprints
2025
置信度 0.74
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Neuromarketing and consumer neuroscience aim to enhance self-report and behavioral techniques by assessing neurophysiological and psychophysiological reactions that are frequently challenging to quantify. This study consolidates non-invasive tools frequently e…
preprints
Pradeep K, SUSLOV E.V., Rajalakshmi S.A., Cruz-Correia Ricardo J. 等
2025
置信度 0.74
NeuromarketingConsumer neuroscienceNeuroscienceCognitive scienceTranscranial magnetic stimulation
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Modern neuroscience research faces critical computational bottlenecks. Neural recordingtechnology advances allow for increasingly large, multidimensional datasets which containnon-stationary signals and complex nonlinear interactions across multiple spatiotemp…
preprints
2025
置信度 0.74
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Abstract Vanilla Recurrent Neural Networks (RNNs) are widely used in neuroscience to model the collective activity of neurons during behavioral tasks. Their high dimensionality and lack of interpretability, however, often make the fundamental features of their…
preprints
2025
置信度 0.74
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Abstract This paper develops the Recursive Informational Curvature (RIC) theory as a unifying framework for understanding free will, agency, and consciousness in an indeterministic universe. While classical libertarian models often fall into the trap of arbitr…
preprints
2025
置信度 0.74
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Mapping low‑intensity magnetic fields is critical across diverse domains, including material and device characterization, neuroscience and biomedical sensing, wearable technologies, geophysics, space exploration, robotics and more recently diagnostics and safe…
preprints
2025
置信度 0.74
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Structural descriptions of qualitative aspects of conscious experience (qualia) offer a rigorous empirical approach to study consciousness. An important outcome of this approach is that structural descriptions of qualia are formalized as mathematical objects. …
preprints
2025
置信度 0.74
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Abstract Machine Learning (ML) models offer significant potential for advancing cell counting applications in neuroscience, medical research, pharmaceutical development, and environmental monitoring. However, implementing these models effectively requires robu…
preprints
2025
置信度 0.74
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The “Control Paradox” introduces an innovative perspective on the relationship between cognitive control and access to deep mental processes. The theory holds that consciousness does not facilitate the emergence of evolutionary functions embedded in the biolog…
preprints
2025
置信度 0.74
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Objectives The cost-effectiveness of new amyloid-targeting therapies (ATTs) for patients with mild cognitive impairment (MCI) or mild dementia due to Alzheimer’s disease (AD) is influenced by assumptions about treatment effectiveness beyond the trial durations…
preprints
2026
置信度 0.74
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Docosahexaenoic acid (DHA) is a polyunsaturated fatty acid enriched in neuronal membranes and myelin and associated with cognitive performance. However, nutritional interventions show inconsistent cognitive effects, partly due to limited knowledge of the neura…
preprints
2025
置信度 0.74
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A critical step in the analysis of large-scale functional brain networks in neuroimaging is parcellation, which defines the nodes of a brain network. Group or atlas-based parcellation schemes use a shared common space, ensuring that each individual has the sam…
preprints
2025
置信度 0.74
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Decoding algorithms can be used to predict motor behaviour from patterns of neural activity. However, most studies rely on subject-optimized models, limiting generalization and scalability to novel subjects and tasks. Building on recent advances in deep learni…
preprints
2025
置信度 0.74
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Cognitive neuroscience research often relies on convenience sampling of participants, which can result in biased sample demographics and an under-representation of older adults. There is a need to identify effective routes to widen participation among older ad…
preprints
2025
置信度 0.74
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The debate over free will has traditionally been framed as a choice between libertarian indeterminism and hard determinism, with compatibilism attempting to reconcile freedom with deterministic causation. However, this framing overlooks a crucial insight from …
preprints
2025
置信度 0.74
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We propose the Informational Field Consciousness Theory (IFCT), an integrative framework combining information physics, quantum biology, and neuroscience to address the Hard Problem of Consciousness. Central to our thesis is the hypothesis that DNA functions a…
preprints
2025
置信度 0.74
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The self-voice plays a fundamental role in communication and identity, yet remains a relatively neglected topic in psychological science. As AI-generated and digitally manipulated voices become more common, understanding how individuals perceive and process th…
preprints
2025
置信度 0.74
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Translational challenges in neuroscience originate from species-specific differences that limit the generalizability of experimental findings. Comparative approaches can help distinguish conserved from species-specific mechanisms, but their application has bee…
preprints
2025
置信度 0.74
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Abstract Exploring brain activity via high-resolution functional magnetic resonance imaging (fMRI) is important in the field of neuroscience. Traditional methodology leverages statistical analysis to associate the stimulus and brain responses, as well as ident…
preprints
2025
置信度 0.74
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Classical Platonism posits a transcendent realm of ideal Forms, but this metaphysical stance is difficult to reconcile with naturalistic accounts of knowledge and cognition. At the same time, cognitive science and biology increasingly rely on abstract structur…
preprints
2025
置信度 0.74
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The self-voice plays a fundamental role in communication and identity, yet remains a relatively neglected topic in psychological science. As AI-generated and digitally manipulated voices become more common, understanding how individuals perceive and process th…
preprints
2025
置信度 0.74
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Golgi-based staining remains a valuable method for visualising the full morphology of individual neurons, however conventional workflows can be slow, variable, and technically demanding. Here, we present a modified staining protocol designed to provide a pract…
preprints
2026
置信度 0.74
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This paper explores an interdisciplinary framework linking the exceptional Lie group E8 with the architecture and dynamics of the human neocortex. We propose that the structural and algebraic richness of E8 may serve as a candidate symmetry model underlying as…
preprints
2025
置信度 0.74
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A recently published pilot study, "Virtual Reality Exposure Therapy for Chronic Post-TraumaticStress Disorder in Syrian Refugee Women – A Mixed-Methods Pilot Study" by TimotaosBasmaji (2025), demonstrated the effectiveness of culturally adapted Virtual Reality…
preprints
2025
置信度 0.74
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Epilepsy affects more than 52 million people worldwide and has been known since ancient times. Despite this long history, available therapeutic methods—both pharmacological and non-pharmacological—fail to control seizures in over 10% of patients. At the same t…
preprints
2025
置信度 0.74
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Artificial Intelligence (AI) is increasingly used in mental health research, yet there remain few applications focusing on early childhood populations. By analyzing neural signals from naturalistic paradigms that more closely resemble real-world therapeutic in…
preprints
2025
置信度 0.74
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Categorization relies on a dynamic interplay between sensory representation and cognitive control, yet the classical view posits a fixed, feed-forward information flow from the inferotemporal (IT) cortex to the prefrontal cortex (PFC). Whether this hierarchica…
preprints
2025
置信度 0.74
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Purpose: This study aimed to co-design culturally adapted pain neuroscience education (PNE) materials for a Lebanese population. The developed material aimed to enhance patients’ understanding of pain and its influences, offer strategies for self-management, a…
preprints
2025
置信度 0.74
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‘Association’ is certainly one of the most prevalent terms in the study of mind, brain and behavior. It applies to actions, stimuli, neurons, brain areas, ideas, words, etc. However, we argue that this term carries qualitatively different meanings, a largely u…
preprints
2025
置信度 0.74
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Mental health disorders affect millions worldwide, yet our understanding of their underlying mechanisms remains limited, impeding the development of precise and effective treatments. Computational psychiatry, a burgeoning field at the intersection of neuroscie…
preprints
2025
置信度 0.74
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Two clear epidemiological patterns are emerging in human populations: first, a rise in the prevalence of numerous diseases and phenotypic conditions; and second, the increasing appearance of conditions once associated with old age in younger individuals. This …
preprints
2025
置信度 0.74
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Awake mouse fMRI is a powerful tool for both neuroscience and translational research. To minimize head motion during scanning, habituation under physical restraint is commonly used. However, it remains unclear how stress levels and head motion evolve during ha…
preprints
2025
置信度 0.74
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Over the years, there have been numerous accounts of the events involved in the discovery of the default mode network (DMN), but as different accounts have multiplied and the DMN has surfaced in the popular media, a misconception has crept into a part of that …
preprints
2025
置信度 0.74
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This paper establishes the ontological fusion of foliation and gravitation within the Timeless Counterspace Shadow Gravity (TCGS) and SEQUENTION framework. We posit that the observable 3D universe (\( \Sigma \)) is a shadow projection of a static 4D Counterspa…
preprints
2025
置信度 0.74
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Virtual reality (VR) is a powerful medium for eliciting emotional states in controlled yet immersive conditions, making it valuable in affective neuroscience and human-computer interaction research. Thus, VR enables multisensory experiences that enhance the se…
preprints
2025
置信度 0.74
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Resting-state electroencephalogram (EEG) dynamics have been proposed as neural markers of individual cognitive abilities. Previous reports linked fluid intelligence with signal complexity derived from multivariate multiscale sample entropy and with microstate …
preprints
2025
置信度 0.74
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There is a growing interest in psychological tasks that closely correspond to specific neural computations for studying brain-behavior associations across development and in disease. The psychometric properties of such tasks, particularly their reliability, ar…
preprints
2025
置信度 0.74
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Awake behaving animal experiments paired with multichannel electrode recordings have advanced motor systems neuroscience in creating models of how the mammalian brain controls move-ments. However, growing theoretical and experimental evidence question the gene…
preprints
2025
置信度 0.74
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Background: The search for meaning (Logos) is widely recognized as a primary determinant of resilience. However, current psychological models often fail to account for the metabolic cost of maintaining coherent narratives in high-entropy environments. Objectiv…
preprints
2025
置信度 0.74
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Characterising the mechanisms underlying naturalistic defensive behavior remains a significant challenge. While substantial progress has been made in unravelling the neural basis of tightly constrained behaviors, a critical gap persists in our comprehension of…
preprints
2025
置信度 0.74
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Neuro-XR refers to the amalgamation of neuroimaging and extended reality (XR) including augmented, mixed and virtual reality. Both sets of technology have developed rapidly and in isolation, and here we show that they have great potential when combined. Mobile…
preprints
Clíona L Murray, Nicholas Alexander, Paola Pinti, Samantha Gregory 等
2025
置信度 0.74
Cognitive neuroscienceCognitive scienceCognitionPsychologyNeuroscience
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We at EJN are thrilled to introduce Dr. Christelle Baunez as the latest scientist for our series of Women in Neuroscience. We began this series to bring visibility and recognition to the superb women scientists working in our community (Helmreich et al., 2017)…
preprints
2025
置信度 0.74
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Coherence appears across physics, biology, neuroscience, cognition, and collective systems as a common signature of stability and organization. Yet existing theories describe coherence through domain-specific constructs-order parameters, morphogen fields, sync…
preprints
2025
置信度 0.74
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Understanding how neural activity gives rise to cognitive processes such as selective attention is a fundamental goal of neuroscience. An important but often overlooked advance towards this goal requires the development and sharing of rigorous and reproducible…
preprints
2025
置信度 0.74
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Personality disorders (PDs) are characterized by rigid and maladaptive patterns of self- and interpersonal functioning, leading to high clinical burden and limited treatment outcomes. Schema Therapy (ST), an integrative psychotherapy rooted in cognitive-behavi…
preprints
2025
置信度 0.74