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Pediatric obesity is a complex, multifactorial pandemic with serious early-onset comorbidities, including prediabetes, type 2 diabetes, metabolic dysfunction-associated steatotic liver disease (MASLD), and cardiovascular disorders. While lifestyle modification…
pubmed
Amitrano M, Mondillo G, Emiliano M, Santoro UP
2026 Aug 11
置信度 0.82
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The microtubule-associated protein tau, encoded by the MAPT gene, serves as a major component of the neuronal cytoskeleton, facilitating the assembly, stabilization, and spatial organization of microtubules. Much of the work on tau has focused on the low-molec…
pubmed
Fischer I
2026 Aug 20
置信度 0.82
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In the biosynthesis of heme the tetrapyrrole hydroxymethylbilane is converted enzymatically to uroporphyrinogen III whereas conversion to uroporphyrinogen I occurs spontaneously. Both are substrates for uroporphyrinogen decarboxylase (UROD) but only the III is…
pubmed
Smith AG
2026 Aug 14
置信度 0.82
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Ovarian cancer (OC) remains the most lethal gynecological malignancy, mostly due to its frequent diagnosis at advanced stages, early peritoneal dissemination, ascites formation, and limited sensitivity of currently available approaches for early detection. Ext…
pubmed
Shefer A, Ivanova E, Chernyshova A, Tamkovich S
2026 Aug 7
置信度 0.82
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Fluorescence correlation spectroscopy (FCS) measures spontaneous temporal fluorescence fluctuations within a femtolitre observation volume to extract, with single-molecule sensitivity, the concentration, mobility, oligomeric state, and interactions of proteins…
pubmed
Saadatmand ZN, Ghaderinejad N, Hinde E
2026 Aug 6
置信度 0.82
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The nucleolus has emerged as a dynamic and multifunctional subnuclear organelle that integrates ribosome biogenesis with cellular growth and stress signalling. Dysregulation of nucleolar function is increasingly recognised as a central driver of human disease,…
pubmed
Delfino O, Xuan J, Hein N, Ferreira R 等
2026 Jul 31
置信度 0.82
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Non-coding RNAs (ncRNAs) are the biggest class of regulatory molecules in the human genome, which constitute ~98% of total transcripts, and were once considered as "transcriptional noise". This review will focus on the newly identified functions of non-coding …
pubmed
Qiu L, Xu Z, Xu J, Lv Z 等
2026 Jul 29
置信度 0.82
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Chronic diseases and aging-related disorders are driven by interconnected mechanisms, including oxidative stress, low-grade inflammation, metabolic dysregulation, and glycation. Targeting these overlapping pathways remains a major challenge for conventional si…
pubmed
Nazir A, Bava P, Hussain A, Amna T 等
2026 Aug 18
置信度 0.82
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Carbapenem-resistant Enterobacterales (CRE) represent one of the most important antimicrobial resistance threats in Europe, particularly in healthcare settings. Their increasing epidemiological significance is driven by the dissemination of carbapenem-resistan…
pubmed
Kuszewska K, Klesiewicz K, Leśniak P, Chmielarczyk A
2026 Aug 15
置信度 0.82
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Species of the genus Streptococcus constitute important pathogens in human and veterinary medicine, being responsible for a wide spectrum of infections ranging from mild illnesses to severe invasive pathologies. Although β-lactams continue to be effectiv…
pubmed
de Sousa T, Silva C, Pereira JE, Igrejas G 等
2026 Aug 3
置信度 0.82
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Achondroplasia is the most common genetic skeletal dysplasia associated with disproportionate short stature and is primarily caused by gain-of-function variants in the fibroblast growth factor receptor 3 (FGFR3) gene. Constitutive FGFR3 activation disrupts gro…
pubmed
Șerban RC, Mitut-Veliscu A, Dumitra A, Marica L 等
2026 Aug 21
置信度 0.82
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Background/Objectives : Outborn neonates-those born outside tertiary perinatal centres and transferred postnatally-may experience higher mortality and morbidity than inborn infants. This systematic review without meta-analysis synthesised contemporary evidence…
pubmed
Damian RO, Boldeanu L, Cucu MG, Siminel MA 等
2026 Aug 10
置信度 0.82
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Developmental and/or epileptic encephalopathy with spike-wave activation in sleep (D/EE-SWAS), previously described as continuous spike-wave during slow-wave sleep (CSWS) or electrical status epilepticus in sleep (ESES), is a childhood-onset disorder character…
pubmed
Samanta D
2026 Jul 27
置信度 0.82
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Synthetic antioxidants are attracting more interest as research moves beyond their traditional use as preservatives in food and materials. Recent studies are exploring how these redox-active molecules might be used in medicine. This review looks at how synthet…
pubmed
Vergara D, Lizama F, Arias-Fuentes C, Chávez-Ángel E 等
2026 Aug 5
置信度 0.82
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Oxidative stress is a major driver of chronic disease, making natural polyphenols attractive scaffolds for modulating inflammation, proteostasis, and cell fate. However, green-tea catechins possess a twisted, conformationally flexible flavan-3-ol framework tha…
pubmed
Fukuhara K, Nakanishi I, Ito H, Shimizu W 等
2026 Aug 1
置信度 0.82
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To describe the genetic resolution rate, molecular findings, and genotype-phenotype correlations of non- ABCA4 and non- BEST1 inherited macular dystrophies (IMDs) within an Irish inherited retinal disease (IRD) registry.
pubmed
Harford D, Conway M, Moran B, Zhu J 等
2026 Aug 20
置信度 0.82
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Biomolecular condensates are dynamic membraneless organelles composed of proteins and RNAs that assemble through multivalent interactions and provide cells with powerful means to regulate gene expression in space and time. Different epitranscriptomic marks suc…
pubmed
Sprecher Y, Sevilla-Sharon M, Moshitch-Moshkovitz S
2026 Aug 19
置信度 0.82
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Background: To assess how historical patterns in retinitis pigmentosa (RP) gene inheritance, functional category, and phenotypic onset may inform the remaining unsolved RP discovery space. Methods: We manually reviewed PubMed-indexed primary reports in the Ret…
pubmed
Wong AXJ, Chua Z, Guo J, Tay HG 等
2026 Aug 12
置信度 0.82
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Background : CLTC -related neurodevelopmental disorder is a rare condition primarily characterized by global developmental delay (GDD) and intellectual disability (ID). To date, approximately 41 cases involving CLTC gene alterations have been reported. We pres…
pubmed
Yang X, Pan R, Yu F, Wu H 等
2026 Aug 8
置信度 0.82
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Individuals with Phelan-McDermid Syndrome (PMS) present with a variety of symptoms, including a breadth of behavioral issues. Clinically assessing behavior in PMS remains challenging due to the overabundance of behavioral assessments and the lack of tools vali…
pubmed
Payne E, Sarasua SM, Rogers C, Martin R 等
2026 Aug 5
置信度 0.82
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Congenital heart defects (CHD) occur in 1% of live births, with an estimated at least 33% of affected infants having genetic defects. It has become standard to screen children with CHD for genetic findings that could aid clinical decision-making, yet modern te…
pubmed
Devine D, Tien A, He H, Baust T 等
2026 Jul 31
置信度 0.82
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Background : Rice breeding requires faster development of high-yielding, climate-resilient, resource-efficient, and high-quality cultivars for production systems exposed to environmental variability and increasing input constraints. Genomic selection offers an…
pubmed
Chu HD, Nguyen TQ, Nguyen LV, Chuong NN 等
2026 Jul 30
置信度 0.82
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The major histocompatibility complex (MHC) is a well-known gene complex that plays a fundamental role in immune recognition; however, its influence on reproductive processes in cattle is not yet fully established, particularly regarding how it modulates the fe…
pubmed
Faverzani LB, Zwirtes AK, Rodrigues DPA, Machado TF 等
2026 Jul 30
置信度 0.82
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Background/Objectives : DNA-based identification of degraded human remains represents a major challenge in forensic science, particularly in cases involving burned, fragmented, or commingled bodies. Advances in forensic genetics have expanded the analytical ca…
pubmed
Sessa F, Francaviglia M, Dervišević E, Zuccarello P 等
2026 Jul 28
置信度 0.82
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Leukodystrophies (LDs), a group of heterogeneous genetic disorders, are characterized by selective involvement of cerebral white matter, including abnormal white matter development and/or progressive degeneration. Oligodendrocytes, astrocytes, microglia, axons…
pubmed
Yang Z, Zhang W, Yu F, Duan X 等
2026 Jul 26
置信度 0.82
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Congenital anomalies of the kidney and urinary tract (CAKUT) are the leading cause of pediatric chronic kidney disease (CKD) and comprise a heterogeneous group of developmental disorders with a substantial genetic contribution. Advances in next-generation sequ…
pubmed
Nurcombe ZW, Mougharbel L, Kitzler TM
2026 Jul 24
置信度 0.82
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Neonatal encephalopathy (NE) is a major cause of neonatal mortality and long-term neurological disability. Although hypoxic-ischaemic encephalopathy (HIE) is the most common cause, several genetic disorders may mimic or coexist with hypoxic-ischaemic injury. N…
pubmed
Colacurci D, Sarno L, Fiore E, Raimondi F 等
2026 Jul 24
置信度 0.82
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Primary mitochondrial diseases (PMDs) are one of the most common genetic disorders with an estimated prevalence of 1 in 4300. This review article summarises the latest updates in the field of mitochondrial medicine over the last decade. The availability of exo…
pubmed
Lim AZ, Moe AM, Stefanetti RJ, Ng YS
2026 Jul 23
置信度 0.82
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Liquid biopsy is now an established component of precision oncology, and its clinical implementation to date has been led by cell-free DNA (cfDNA) and circulating tumor DNA (ctDNA) assays. These assays report genomic alterations, yet they may be limited by low…
pubmed
Pernagallo S, Tisato V, Gemmati D
2026 Jul 23
置信度 0.82
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Background: Chordoma is a rare malignant bone tumor thought to arise from remnants of the embryonic notochord. Its management remains challenging because of its proximity to critical neurovascular structures and its high propensity for local recurrence. Curren…
pubmed
Mohiuddin M, Vaca B, Haynal E, Bin-Alamer O 等
2026 Aug 19
置信度 0.82
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Metastatic colorectal cancer remains associated with poor prognosis despite major therapeutic advances, highlighting the need for robust biomarkers to refine treatment selection and monitor disease dynamics. This review summarizes emerging predictive and progn…
pubmed
Benidovskaya E, Huyghe N, Giolito MV, Coulie P 等
2026 Aug 17
置信度 0.82
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Squamous cell carcinoma of the anal canal (SCAC) is a rare malignancy whose incidence has been steadily increasing worldwide. Persistent infection with high-risk human papillomavirus (HPV), particularly HPV16 and HPV18 genotypes, is the main etiological factor…
pubmed
Callegarin M, Angerilli V, Gasparello J, Bergamo F 等
2026 Aug 12
置信度 0.82
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Background/Objectives: We describe how our in-house bioinformatics platform, Flype, has evolved from being a variant repository to an enterprise role as an electronic medical record (EMR) content provider, powering molecular pathology reporting, pharmacogenomi…
pubmed
Helseth DL Jr, Miller N, Yang M, Wittich H 等
2026 Aug 10
置信度 0.82
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Early-onset colorectal cancer (EOCRC) among individuals under age 50 is increasing globally. Lifestyle factors such as obesity, metabolic comorbid conditions, poor diet and sedentary behaviours are linked to EOCRC, but critical gaps remain in identifying addit…
pubmed
Tian R, Azadnajafabad S, Waters EA, Balskus EP 等
2026 Aug 26
置信度 0.82
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The three-dimensional (3D) genome provides an essential layer of organization that shapes genome function in space and time. Chromatin compartments and topologically associating domains (TADs) arise from the interplay between intrinsic properties of chromatin …
pubmed
Smith RG, Wilson HM, Schiela KL, Liu Y
2026 Aug 26
置信度 0.82
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Herpes simplex virus type 1 (HSV-1) has emerged as a versatile platform for gene delivery, oncolytic immunotherapy, and neural circuit mapping. Its large genome, broad tropism, and engineering flexibility enable delivery of large or multi-component payloads th…
pubmed
Yang B, Liu ZY, Xiong F, Cheng H 等
2026 Aug 26
置信度 0.82
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The DNA damage response (DDR) network maintains genomic integrity, functions as a signaling hub that viruses exploit to drive pathogenesis, and constitutes a central interface between viral infection and host cell fate. This review discusses the molecular mech…
pubmed
Song M, Wang S, Fei X, Guo G
2026 Aug 26
置信度 0.82
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Whole genome sequencing (WGS) resolves transmission relationships in carbapenemase-producing Enterobacterales (CPE) outbreaks at nucleotide level. Whether this translates into changed infection prevention and control (IPC) practice or improved patient outcomes…
pubmed
Sun L, Chua Ee-Yong P, Mukherjee S, Ann KJ
2026 Aug 26
置信度 0.82
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Transposable elements (TEs) are mobile genetic sequences that have long resided within host genomes. Over this shared history, a continuous process of co-evolution has forged a diverse array of dynamic TE-host interactions. In an evolutionary arms race, hosts …
pubmed
Son JH
2026 Aug 26
置信度 0.82
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Sarcopenia is the age-related progressive decline in both skeletal muscle mass and function. It acts as an exacerbator of multimorbidity, engaging in bidirectional pathological cycles with multiple chronic diseases, and contributes substantially to increased m…
pubmed
Fu G, Chen L, Wang Z, Fang H
2026 Aug 26
置信度 0.82
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Protein overexpression is crucial in many diseases and can lead to antibiotic resistance by increasing the expression of drug targets or resistance genes. Using high-throughput colony imaging, we performed a quantitative genome-wide study of protein overexpres…
pubmed
Müller J, Gadjisade N, Angermayr SA, Ansmann G 等
2026 Aug 26
置信度 0.82
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Development of cell-based model systems for studying the urea cycle has been motivated by the urgent need to develop and evaluate treatments for urea cycle disorders, such as gene therapies currently in clinical trials, and to conduct mechanistic studies of th…
pubmed
Caldovic L
2026 Aug 20
置信度 0.82
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Tropical theileriosis, caused by the tick-transmitted apicomplexan parasite Theileria annulata, remains a major constraint on cattle production across North Africa, the Mediterranean basin, the Middle East and South Asia. Current control depends on acaricides,…
pubmed
Azeem A, Khan MK, Mahmood MS, Abbas RZ 等
2026 Aug 26
置信度 0.82
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Many patients are medically unfit for or refuse radical cystectomy. Few post-chemotherapy bladder-sparing active surveillance programs have reported on non-muscle-invasive recurrences and treatment outcomes. Here, we present data on non-muscle invasive recurre…
pubmed
Joffe BI, Pingle SR, Laplaca C, Christin JR 等
2026 Aug 26
置信度 0.82
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To provide recommendations on use of medical therapies for patients with stage I-III hormone receptor-positive, HER2-negative breast cancer.
pubmed
Caswell-Jin JL, Somerfield MR, Khan MA, Kimmick GG 等
2026 Aug 26
置信度 0.82
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Population genomic studies in non-model organisms increasingly depend on whole-genome resequencing, yet translating raw reads into reliable variant callsets remains a practical challenge due to the complexity of multi-step bioinformatics pipelines and the abse…
pubmed
Mirchandani C, Omarjee A, Achaz G, Enbody E 等
2026 Aug 26
置信度 0.82
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Recent advances in breast cancer management have transformed treatment across molecular subtypes and expanded the role of precision oncology. Hormone receptor-positive (HR-positive), human epidermal growth factor receptor 2-positive (HER2-positive), HER2-low, …
pubmed
Tobin W
2026 Sep 1
置信度 0.82
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Lipoprotein(a) [Lp(a)] is a low-density lipoprotein-like particle covalently bound to apolipoprotein(a) and encoded by the LPA gene. Elevated plasma levels of Lp(a) are a well-established, independent, and causal risk factor for cardiovascular disease. While t…
pubmed
Appiah LT, Akumiah FK, Idan JS, Amponsah GM 等
2026
置信度 0.82
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Mucopolysaccharidosis type II (MPS II; also known as Hunter syndrome), is a rare X-linked lysosomal disease that leads to progressive tissue and organ damage. Early treatment is essential as most symptoms of MPS II are not reversible. Consequently, MPS II has …
pubmed
Gaviglio A, Bonhomme N, Burton B, Ellinwood NM 等
2026 Aug 12
置信度 0.82
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Krabbe disease is an autosomal recessive leukodystrophy caused by a deficiency of the lysosomal enzyme galactosylceramidase (GALC), responsible for the degradation of galactolipids, resulting in toxic psychosine accumulation and progressive demyelination of th…
pubmed
Schecter DR, Donnelly C, White A, Raynes H 等
2026 Jul 29
置信度 0.82
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Both genetics and the environment affect the phenotypes of polycystic kidney diseases (PKD), such as autosomal dominant (AD) PKD, autosomal recessive (AR) PKD and nephronophthisis (NPH). Variable phenotypes, pleiotropy, divergent severity and progression, even…
pubmed
DeLoriea J, Casey C, Shearer L, Chen V 等
2026 Aug 10
置信度 0.82
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Background: Epigenomics has emerged as an essential field in modern molecular biology, providing a critical layer of gene regulation. DNA methylation, histone modifications and alterations to the chromatin accessibility of DNA have been widely associated with …
pubmed
Baruri S, Batra L, Adhikari S, El-Baz A
2026 Aug 7
置信度 0.82
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Drought poses a major threat to global food security, making it critical to understand the molecular mechanisms underlying plant responses to water scarcity. Epigenetic modifications, including DNA methylation and histone alterations, play central roles in reg…
pubmed
Talarico E, Greco E, Camoli M, Guarasci F 等
2026 Aug 6
置信度 0.82
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Non-communicable diseases (NCDs), including cancer, cardiovascular, neurodegenerative, autoimmune, and allergic diseases, account for a significant amount of global morbidity and mortality. Chronic viral infections have not been recognized as NCDs, despite the…
pubmed
Caldarelli M, Rio P, Renna C, Marrone A 等
2026 Aug 12
置信度 0.82
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Introduction/Aims: Myopathies with Tubular Aggregates (TAM) are rare, chronic neuromuscular disorders that may be inherited or acquired. The aim of this report is to present the diagnostic pathway and the challenges encountered in a family with three members a…
pubmed
Ostojić S, Milenković S, Pavlović S, Kovačević G 等
2026 Aug 5
置信度 0.82
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High-grade pulmonary neuroendocrine carcinoma (HGNEC-L), including SCLC and LCNEC, is aggressive and usually treated according to SCLC paradigms. The clinical relevance of de novo actionable genomic alterations (AGA) remains incompletely defined.
pubmed
Raphael A, Peled N, Gillis R, Nechushtan H 等
2026 Aug 18
置信度 0.82
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Guidelines in early breast cancer place adjuvant chemotherapy before radiotherapy, permit radiotherapy concurrently with endocrine and anti-HER2 agents, but discourage it before or during cytotoxic chemotherapy. This narrative review asks whether that conventi…
pubmed
Georgescu MT
2026 Aug 13
置信度 0.82
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Artificial intelligence (AI) is rapidly transforming cardiovascular medicine, driven by the increasing availability of large-scale clinical data and advances in machine learning. Early computational applications in cardiology were primarily limited to rule-bas…
pubmed
Rech L
2026 Jul 25
置信度 0.82
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Nicotinamide adenine dinucleotide (NAD + ) is a fundamental metabolic cofactor and signaling molecule that supports redox reactions, DNA repair, chromatin regulation, stress adaptation, inflammation, and neuronal maintenance. Age-associated NAD + decline has b…
pubmed
Sun Y, Li B, Qian Z
2026 Aug 21
置信度 0.82
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Medicinal fungi are important sources of natural medicines and are rich in a wide range of secondary metabolites with significant bioactivities, including terpenoids and alkaloids. As one of the core tools of systems biology, metabolomics has developed from si…
pubmed
Tong Y, Tang C, Jia B, Tang H 等
2026 Aug 16
置信度 0.82
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Background: Visceral obesity is increasingly recognised not as a simple excess of adipose tissue, but as a systemic pathological condition characterised by profound metabolic, endocrine, and immune dysregulation. Visceral adipose tissue (VAT) operates as an au…
pubmed
Mariotti M, Merenda V, Arrigoni F, Tamburlin N
2026 Jul 29
置信度 0.82
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The exponential rise in global plastic production has resulted in the widespread environmental dissemination of micro- and nanoplastics (MNPs) across air, water, and biological systems. Inhalation of airborne MNPs represents a biologically plausible pathway of…
pubmed
Andrikopoulou C, Koletsis NE, Leivaditis V, Mulita F 等
2026 Jul 26
置信度 0.82
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Acute Myeloid Leukemia (AML) is a heterogeneous group of aggressive blood-related cancers that arise from the hematopoietic system, requiring specific treatments due to their genetic diversity and complexity. Artificial intelligence (AI) has emerged as a trans…
pubmed
Niscola P, Gianfelici V, Laureana R, Giovannini M 等
2026 Jul 24
置信度 0.82
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Cardiogenesis begins during gastrulation with the bilateral specification of precardiac mesoderm on either side of the embryo. These fields fuse at the embryonic midline to form the linear heart tube, which subsequently undergoes rightward looping and chamber …
pubmed
García-Padilla C, Lozano-Velasco E, García-López V, Aránega A 等
2026 Aug 7
置信度 0.82
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Esophageal squamous cell carcinoma (ESCC) is the most prevalent cancer in Somalia and constitutes a major public health concern in the Horn of Africa. Despite its high incidence, the molecular mechanisms underlying ESCC are not well characterized. This scoping…
pubmed
Rooraye HM, Lukman Y, Suppian R, Ali A 等
2026 Aug 26
置信度 0.82
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Human T-cell lymphotropic virus type 1 (HTLV-1) is a persistent human retrovirus associated with severe outcomes, most notably adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Despite lifelong infec…
pubmed
Akbarin MM, Farjami Z, Álvarez HR
2026 Aug 26
置信度 0.82
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Transcriptional repression is a fundamental regulatory mechanism that enables precise control of gene expression in response to developmental signals and environmental stimuli. Synthetic biology can leverage this process within plants to engineer programmable …
pubmed
Clark LA, Pfotenhauer AC, Lenaghan SC, Stewart CN Jr
2026 Aug 26
置信度 0.82
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Immune checkpoint inhibitor (ICI)-based combinations represent the standard first-line treatment for metastatic clear cell renal cell carcinoma (mRCC), although robust biomarkers for treatment selection remain undefined. We conducted a systematic review to ide…
pubmed
Valsecchi AA, Maffezzoli M, Cursano MC, Di Costanzo F 等
2026 Aug 26
置信度 0.82
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The cohesin complex is a highly conserved, ring-shaped protein assembly that plays fundamental roles in chromosome biology. Originally identified as the molecular glue that holds sister chromatids together from DNA replication until cell division, cohesin has …
pubmed
Choi EH
2026 Aug 19
置信度 0.82
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Hantaviruses are zoonotic RNA viruses responsible for two severe human diseases: hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS). Worldwide case fatality rates vary from 1% to 40%. Although single-layer genomics, tra…
pubmed
Najafi S, Jojani M, Najafi K, Roviello GN
2026 Jul 23
置信度 0.82
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Fibrosis emerges when normally self-limiting tissue repair fails to resolve and overlapping phases of injury, stromal activation, extracellular matrix (ECM) deposition and remodelling become sustained. MicroRNAs (miRNAs) shape this transition by coordinating s…
pubmed
Armstrong L, McKenna DJ, Mihalovova E, Gribben RD 等
2026 Aug 17
置信度 0.82
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Hydrogel-enabled adoptive cell therapy (ACT) offers a localized and controllable strategy for improving cellular immunotherapy in solid tumors. Hydrogels can enhance cell retention and persistence, support immune cell function within the tumor microenvironment…
pubmed
Shin JH, Song Y, Park J
2026 Aug 1
置信度 0.82
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This narrative review provides a historical perspective on how observational research on type 2 diabetes has been developed and consolidated over the last 50 years and how well-designed cohort studies will provide us with knowledge for research and practice in…
pubmed
Kim SH, Arora I, Agyemang C, Anjana RM 等
2026 Aug 26
置信度 0.82
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Cobalamin-related remethylation disorders (cbl-RD) are rare, heterogenous conditions with a wide phenotypic spectrum, including prenatal and early infantile manifestations. Data on pregnancy outcomes in affected women and the efficacy and safety of prenatal tr…
pubmed
Stepien KM, Sykut-Cegielska J, Sloan J, Piazzon F 等
2026 Sep
置信度 0.82
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Reporter-expressing recombinant influenza A viruses (IAVs) have emerged as powerful tools for studying viral infection, host-pathogen interactions, and the identification and characterization of prophylactic and/or therapeutic countermeasures for the treatment…
pubmed
Barre RS, Nath H, Nogales A, Abdelwhab EM 等
2026 Aug 26
置信度 0.82
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Wearable wristwatch-type cuff oscillometric blood pressure (BP) monitors represent a new category of BP devices and are the first wearable monitors to use established cuff-oscillometric BP measurement technology. This consensus statement by the European Societ…
pubmed
Stergiou GS, Menti A, Asayama K, Kollias A 等
2026 Oct 1
置信度 0.82
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Intracytoplasmic sperm injection (ICSI) transformed the treatment of severe male factor infertility by reducing the sperm-cell-to-oocyte ratio to one-to-one. This review summarizes current approaches to identify and utilize rare spermatozoa in men with cryptoz…
pubmed
Xie P, Cheung S, Ng L, De Jesus A 等
2026 Jul 28
置信度 0.82
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Denmark has a well-established tradition of utilizing national registries for epidemiological research. Healthcare services in Denmark are managed by five administrative regions and documented in electronic health records (EHRs). While certain EHR data are man…
pubmed
Thomsen MK, Dalby HR, Schram A, Jensen SK 等
2026
置信度 0.82
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Asthma and chronic obstructive pulmonary disease (COPD) are highly prevalent heterogeneous airway diseases in which a subset of patients with severe disease have a disproportionate share of morbidity and mortality, largely through exacerbations. Major immunolo…
pubmed
Tejwani V, Siddharthan T, Majumdar U, Hatipoğlu U 等
2026
置信度 0.82
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Microbial communities from deep subsurface petroleum reservoirs are adapted to hydrocarbon-rich, oxygen-limited, and physicochemically extreme environments. However, genome-resolved knowledge of petroleum reservoir microbiomes from Pakistan remains largely une…
pubmed
Tayyaba S, Amin A, Zulfiqar S, Ahmed I
2026
置信度 0.82
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With the advances in molecular biology, molecular testing has been incorporated into pathogen testing for infectious diseases. There are two main objectives for the molecular diagnosis of infectious diseases- first, to detect pathogen genes by using highly sen…
pubmed
Takata M, Chikumi H, Yoshifuji A
2026 Aug
置信度 0.82
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Teratology, the study of congenital anomalies, has developed from a descriptive discipline into a mechanistic science focused on the proximate causes of developmental defects, meaning how such anomalies arise during development. However, a comprehensive unders…
pubmed
Kon T
2026 Jan-Feb
置信度 0.82
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Inherited arrhythmia syndromes (IAS)-including long QT syndrome (LQTS), catecholaminergic polymorphic ventricular tachycardia (CPVT), and Brugada syndrome (BrS)-are important causes of sudden cardiac death in the young. Although molecular diagnosis and cascade…
pubmed
Sardana M, MacIntyre C, Giudicessi JR, Ackerman MJ
2026 Aug 26
置信度 0.82
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Migraine affects approximately 14% of adults, but the molecular mechanisms underlying susceptibility remain incompletely understood. Although genome-wide association studies (GWAS) have identified many migraine risk loci, translating these associations into bi…
pubmed
Ghaffar A, Nyholt DR
2026 Jul 31
置信度 0.82
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In children with atopic dermatitis (AD), itch-related nighttime scratching is associated with significant sleep disturbances. The aim of this study is to report the feasibility of using the Emerald touchless sensor to quantify nighttime scratching and sleep pa…
pubmed
Rubin CJ, Lee LW, Assa'ad A, Lara-Corrales I 等
2026 Aug 25
置信度 0.82
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Environmental enrichment (EE) paradigms in rodents have long demonstrated that enhanced sensory, cognitive, social, and motor stimulation positively impacts brain function, improving learning, memory, and neuroplasticity. These effects have significant implica…
pubmed
Kurowska M, Miozzo F, Schroeder R, Machnicka MA 等
2026 Aug 26
置信度 0.82
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The 3D structure of chromatin is altered in cancer. In healthy cells, the genome is folded into functional 3D structural elements, including chromosomes, chromatin compartments, domains and loops. Cancer-associated alterations can modify each of these structur…
pubmed
Franceschini GM, Georgakopoulou K, Ciriello G, Oricchio E
2026 Aug 25
置信度 0.82
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Crop wild relatives provide essential genetic diversity for improving crop resilience; however, pre- and post-zygotic barriers often restrict interspecific hybridization. Recent approaches enable their effective use in crop improvement programs. Crop wild rela…
pubmed
Thudi M, Naik YD, Jha UC, Reddy MSS 等
2026 Aug 25
置信度 0.82
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Anaplastic thyroid cancer (ATC) is one of the most aggressive human malignancies, defined by rapid progression, early metastasis and resistance to nearly all standard therapies. Although it accounts for less than 2% of thyroid cancers, ATC causes a disproporti…
pubmed
Noronha S, Kebebew E, Boufraqech M
2026 Aug 25
置信度 0.82
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Mitochondria coordinate metabolic and signaling pathways that influence cancer progression across multiple stages of the disease. Beyond supporting tumor growth, mitochondria contribute to metastatic dissemination and shape interactions between tumor and immun…
pubmed
Gomez-Duran A, Martínez-Reyes I
2026 Aug 26
置信度 0.82
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Type III secretion system effectors (T3SEs) are small bacterial proteins with big biological roles. They act as central molecular mediators of interactions between Gram-negative bacteria and eukaryotic hosts, spanning pathogenic, symbiotic and environmental co…
pubmed
Rosić I, Nikolić I
2026 Aug 26
置信度 0.82
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Lysosomal disorders (LDs) have traditionally been defined by intra-lysosomal substrate accumulation resulting from deficiencies of lysosomal enzymes or associated proteins. Advances in lysosomal biology have demonstrated that lysosomes function as central regu…
pubmed
McCarron EP, Blau N, Eden ER, Platt FM 等
2026 Sep
置信度 0.82
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The blood-brain barrier (BBB) supporting the health of the central nervous system does this by limiting molecular exchange between circulation and brain tissue, although unfortunately this same restriction prevents therapeutically relevant macromolecules from …
pubmed
Amudha S, Ramasamy S, Enoch IVMV
2026 Aug 25
置信度 0.82
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Lineage plasticity has emerged as a central mechanism through which cancer cells adapt to therapeutic pressure, evade immune surveillance, and acquire aggressive phenotypes. Although recognized across tumor types, the regulatory principles governing how cancer…
pubmed
Fraidenburg M, Li L, Kwon R, Ghali F 等
2026 Aug 25
置信度 0.82
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This review systematically summarizes the features of Bacillus subtilis expression systems, the regulatory effects of various promoters on heterologous expression efficiency, and rational modification strategies of promoter core regions. B. subtilis WB600 or W…
pubmed
Li M, Zheng M, Wang P, Liu X 等
2026 Aug 25
置信度 0.82
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Cancer stem cells (CSCs) sustain tumor initiation, therapy resistance, and relapse, yet evade durable control because they switch phenotype, enter quiescence, shelter within protective niches, resist drug efflux, and share markers with normal stem cells. Progr…
pubmed
Chandrasekaran S, Duraisamy N, Jagadeesan M, Palukuri YK 等
2026 Aug 25
置信度 0.82
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Granular activated carbon (GAC) enhances anaerobic digestion (AD) performance, potentially via biofilm promotion, microbial enrichment, and facilitating direct interspecies electron transfer (DIET). In this work, to investigate the role of GAC, DNA was extract…
pubmed
Dang H, Zhang Y, Liu Y
2026 Aug 25
置信度 0.82
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Methylation profile scores (MPSs) aggregate the effects of many DNA methylation (DNAm) sites across the genome into a single continuous value per individual. These scores are rapidly gaining traction in health research, as they translate DNAm patterns into sum…
pubmed
Schuurmans IK, Defina S, Hermans APC, Neumann A 等
2026 Aug 25
置信度 0.82
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Staphylococcus aureus adaptation and persistence within host environments are strongly shaped by lipid availability and host-derived lipid fluxes encountered during infection. The glycerol ester hydrolase Geh, initially characterized as a secreted lipase hydro…
pubmed
Pagot C, Gloux K
2026 Aug 17
置信度 0.82
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Microplastics (<5 mm) are widespread environmental contaminants, with increasing human exposure through ingestion, inhalation, and dermal contact. Their presence in terrestrial, aquatic, and atmospheric systems, along with detection in human tissues su…
pubmed
Lakshmikanthan M, Muthu S
2026 Aug 25
置信度 0.82