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• Oxidative stress and cancer: current insights and therapeutic implications.
  OXIDATIVE STRESS: good or evil? Oxidative stress occurs when the balance between reactive oxygen species (ROS) and antioxidant defenses shifts toward an excess of ROS; while essential in physiological processes, it plays a context-dependent role in cancer, con…
  pubmed Escribano-Cebrián M, Bataller M, Biasini M, García-Mayea Y 等 2026 Aug 22 置信度 0.82
• An ode to the 16S rRNA gene: its history, importance, caveats and future in microbiome research.
  The 16S rRNA gene has - and continues to - play an important role in microbiology. It's universality across prokaryotes and variation across species has allowed the sequencing of its hypervariable regions to be used to distinguish taxa within complex mixed bac…
  pubmed Whelan FJ, Hall LJ 2026 Aug 置信度 0.82
• Single-Cell Glycomics of the Pancreatic Tumor Microenvironment: Technologies, Glyco-Immune Checkpoints, and Tumor-Immune Communication.
  In this Review, we summarize recent conceptual and technological advances in single-cell glycomics, with a particular focus on emerging strategies that enable glycan-resolved analysis of tumor-immune interactions. We highlight single-cell glycan and RNA sequen…
  pubmed Anh DXT, Tateno H 2026 Aug 置信度 0.82
• JCAD/KIAA1462: biology, pathophysiology, and translational perspectives in vascular disease.
  Junctional cadherin 5-associated protein (JCAD/KIAA1462) is an endothelial junctional protein encoded by a locus robustly associated with coronary artery disease and myocardial infarction in genome-wide association studies. Initially identified as a structural…
  pubmed Moriero M, Kraler S, Tirandi A, Di Vece D 等 2026 Aug 25 置信度 0.82
• De novo chromatin remodelling variants in sporadic Chiari 1 malformation.
  Chiari 1 malformation (CM1) is the most common congenital malformation of the human hindbrain. Although prior studies have implicated chromatin-remodeling genes in CM1, the de novo genetic architecture and underlying neurodevelopmental mechanisms remain incomp…
  pubmed Mehta NH, Allington G, Dennis E, Li Q 等 2026 Aug 25 置信度 0.82
• Molecular cartography of breast cancer: decoding genomes, heterogeneity and the tumor microenvironment for personalized targeted therapeutics.
  Breast cancer is a multi-stage disease that unfolds with the utmost complexity and heterogeneity of various cell types; thus, the unraveling of its molecular mechanisms is required to develop improved therapeutic strategies. This review tries to dissect the co…
  pubmed Mathew AA, Ramalingam K, Gibu D, Muhammed Hashim KP 等 2026 Aug 25 置信度 0.82
• Beyond the Ribosome: The Expanding Role of the Nucleolus in Neurodegenerative Pathways.
  The nucleolus, long defined by its canonical role in ribosome biogenesis, has emerged as a critical nexus for cellular homeostasis, stress sensing, and disease pathogenesis. This article synthesizes a broad range of evidence to construct a comprehensive model …
  pubmed Iacono D, Feltis GC 2026 Aug 25 置信度 0.82
• Allelochemical signaling and phytohormone crosstalk in plants: molecular mechanisms and implications for sustainable weed management.
  Phytotoxic effects from allelopathy occur due to signaling pathways that induce alterations in hormonal balance within the plants, thereby hindering weed growth. Signaling crosstalk between various hormones and signaling pathways (Ca 2 ⁺, MAPK, ROS) is …
  pubmed Akhtar N, Aijaz F, Ansari MS, Shadab M 等 2026 Aug 25 置信度 0.82
• Efficacy of PARP inhibitor and immune checkpoint inhibitor combination therapy in PD-L1-negative cancers: a systematic review and meta-analysis.
  Poly (ADP-ribose) polymerase inhibitors (PARPis) can enhance antitumor immunity and improve the efficacy of immune checkpoint inhibitors (ICIs) through PD-L1 upregulation and STING pathway activation. However, the benefit of this combination in PD-L1-negative …
  pubmed Zhou S, Patel V, Kishi N, Akhtar K 等 2026 Aug 25 置信度 0.82
• A Comprehensive Review of Starches From Diverse Millets: Composition, Structure, Functionality, and Strategies for Genetic Improvement.
  Millets are a diverse group of underutilized C 4 cereals with high photosynthetic efficiency and resilience to marginal environments; however, the functional and nutritional potential of their starches remains largely untapped. This review provided a systemati…
  pubmed Amin R, Lu H, Yu J, Xu F 等 2026 Sep 置信度 0.82
• Recent advances in Taxus molecular research: applications in genetic diversity, gene function and metabolic engineering.
  Plants belonging to the genus Taxus are abundant in pharmacologically active constituents, notably Taxol (paclitaxel), which has been extensively employed in the treatment of various cancers. This review aims to achieve a comprehensive and up-to-date overview …
  pubmed Jiang Y, Zhang L, Ma H, Fang Z 等 2026 置信度 0.82
• The microbiome-EBV axis in carcinogenesis bridges commensal influence and viral oncogenesis.
  This review synthesizes current evidence on the emerging role of the host microbiome in Epstein-Barr virus (EBV)-associated tumorigenesis. Moving beyond the traditional virus-host paradigm, we propose the "microbiome-EBV axis" as a conceptual framework for und…
  pubmed Tian X, Ji K, Feng M 2026 置信度 0.82
• Liquid biopsies for detection, characterization, and interception of therapy resistance in thoracic malignancies.
  Therapy resistance remains a leading cause of treatment failure and mortality in thoracic malignancies, despite major advances in targeted therapies and immunotherapies. Resistance evolves through heterogeneous, patient-specific mechanisms, including genetic a…
  pubmed Oner E, M Saini V, Cahill C, O'Toole H 等 2026 置信度 0.82
• Potential for gene silencing by piwi-interacting RNA in three lepidopterans.
  RNA interference (RNAi) has emerged as a promising strategy for insect pest control, yet its application in lepidopterans is hindered by insensitivity to double-stranded RNA (dsRNA). Here, we investigate the piwi-interacting RNA (piRNA) pathway as an alternati…
  pubmed Poudel S, Quito K, Mondal M, Nawaz K 等 2026 置信度 0.82
• Clinical utility of molecular profiling in rare lung neuroendocrine neoplasms.
  Rare lung neuroendocrine neoplasms (LNENs), including pulmonary carcinoids and large-cell neuroendocrine carcinomas (LCNEC), are heterogeneous tumors. Current World Health Organization (WHO) classification primarily relies on morphological features, leading to…
  pubmed Leunissen D, Moonen L, van Weert T, Heijboer F 等 2026 置信度 0.82
• Impact of the 21-Gene Oncotype DX Recurrence Score on Adjuvant Chemotherapy Decision-Making in Invasive Ductal Carcinoma: A Real-World Analysis From a Single Japanese Institution.
  Background The 21-gene Oncotype DX Recurrence Score (RS) assay (Exact Sciences Corporation, Madison, WI) is a genomic test used to inform adjuvant chemotherapy decisions in hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negativ…
  pubmed Terakawa H, Kurokawa Y, Mohri R, Hirata M 等 2026 Jul 置信度 0.82
• Artificial intelligence applications in oxaliplatin-based chemotherapy for colon cancer: advancing prognosis, toxicity prediction, and dose personalization.
  Colorectal cancer (CRC) remains a significant cause of cancer deaths worldwide. Oxaliplatin-based regimens, such as FOLFOX, which form the cornerstone of therapy, are associated with variability in patient responses and toxicities, most notably peripheral neur…
  pubmed Jammoul D, Ajibuwa F, Jammoul M, Schlosser-Hupf S 等 2026 置信度 0.82
• Genome-Wide Prenatal cfDNA Screening and the Obstetric Incidentalome: Maternal Cancer, Placental Mosaicism, and Pregnancy Risk.
  Prenatal cell-free DNA (cfDNA) screening was introduced as a highly accurate test for common fetal aneuploidies, but genome-wide implementation has exposed a broader and more complex clinical landscape. Maternal plasma cfDNA is a composite biological signal ra…
  pubmed Xu M, Liu Y, Gao M, Zhu Y 2026 置信度 0.82
• An evolutionary analysis of lysophospholipid acyltransferases generating membrane phospholipid diversity.
  All living organisms are enclosed by biological membranes composed primarily of phospholipids. The diversification of membrane lipids has shaped key membrane functions, including signaling, membrane protein regulation, and immune responses, and may also have d…
  pubmed Shindou H, Kawai Y 2026 置信度 0.82
• Nitrogen use efficiency in crops under salt stress: from molecular networks to intelligent breeding.
  Soil salinization threatens global arable land and agricultural sustainability, severely reducing crop nitrogen use efficiency (NUE) by disrupting root ammonium and nitrate fluxes, impairing nitrogen-assimilation enzymes, and disrupting carbon-nitrogen (C-N) b…
  pubmed Liu R, Wang L, Wang S, Wang Y 等 2026 置信度 0.82
• Strain-resolved biology of Lactobacillus johnsonii across host systems.
  Lactobacillus johnsonii is widely described as a probiotic species, but current evidence supports a strain-resolved view. Its biological effects depend on strain background, host niche, diet, challenge context and delivery format, including live cells, cell-de…
  pubmed Li M, He J, Chai J, Deng F 等 2026 置信度 0.82
• Self-identified African ancestry and pathomics-derived tumor-infiltrating lymphocyte scores in colon and rectal adenocarcinoma whole-slide images: an exploratory multicohort whole-slide image study.
  AI assisted computed higher tumor infiltrating lymphocyte% (TIL%) scores from hematoxylin and eosin (H&E) stained whole slide images (WSI) may serve as a useful biomarker for stratifying patients for treatment with immune checkpoint inhibitors.
  pubmed Zhang Y, Cheng X, Liao Y, Adams S 等 2026 置信度 0.82
• Editorial: AI-assisted bioinformatics and functional genomics technologies in medicinal plants.
  pubmed Song C, Cao Y, Sabir IA, Zhao W 2026 置信度 0.82
• Pathophysiological frameworks and emerging preventative strategies in SUDEP.
  Sudden Unexpected Death in Epilepsy (SUDEP) represents a leading cause of epilepsy-related mortality, reflecting a severe disruption of systemic physiology that remains challenging to address using standard clinical protocols. Although generalized tonic-clonic…
  pubmed Xu C, Wang Y, Nie S, Gao J 等 2026 置信度 0.82
• Advanced diagnostic methods for nontuberculous mycobacterial infections.
  Nontuberculous mycobacteria (NTM) represent an increasingly significant cause of pulmonary and extrapulmonary infections, but are sometimes misinterpreted as tuberculosis (TB) owing to overlapping clinical and microbiological characteristics. Conventional diag…
  pubmed Singh S, Singh AK, Kumar S, Singh N 等 2026 置信度 0.82
• AI-powered medicinal chemistry and translational drug development.
  Medicinal chemistry sits at the center of modern drug discovery, yet translating molecular designs into approved medicines remains slow, expensive, and prone to high attrition across the pipeline from target identification to clinical validation. Artificial in…
  pubmed U K, Zhang SM, Yu Z, Zhang Z 等 2026 Aug 25 置信度 0.82
• Saliva Liquid Biopsy for Detection of Oral and Systemic Diseases.
  Saliva has emerged as a compelling liquid biopsy for the non-invasive diagnosis and monitoring of both oral and systemic diseases. Secreted by major and minor salivary glands and enriched by gingival crevicular fluid, epithelial turnover, immune mediators, mic…
  pubmed Choi I, Zander A, Chan B, Syedmoradi L 等 2026 Aug 25 置信度 0.82
• Multimodal spatial profiling reveals distinct myeloid-defined ENKTL subgroups and tumor-myeloid cooperativity within prognostic inflammatory niche.
  Extranodal NK/T-cell lymphoma (ENKTL) is an aggressive Epstein-Barr virus (EBV)-associated malignancy with a heterogeneous tumor microenvironment, yet macrophage heterogeneity and tumor-macrophage crosstalk remain poorly defined. Here, we integrate spatial tra…
  pubmed Deng L, Liu M, Linton REA, Hu K 等 2026 Aug 24 置信度 0.82
• Arrestins as programmable integrators of GPCR signaling: structural microstates, spatiotemporal logic, and therapeutic control.
  Arrestins were originally defined as terminators of G protein-coupled receptor (GPCR) signaling, yet structural and mechanistic advances now reveal them as programmable, spatiotemporal integrators of cellular signaling. Recent cryo-electron microscopy studies …
  pubmed He Q, Zhao LH, Xu HE 2026 Aug 25 置信度 0.82
• Maternal small RNAs as gatekeepers of hybrid compatibility in plants and animals.
  Hybridization between species can enable introgression of advantageous traits, yet hybrid offspring often show reduced fitness, sterility, or developmental arrest due to postzygotic hybrid incompatibility. Understanding the molecular bases of these barriers co…
  pubmed Dziasek K, Köhler C 2026 Aug 26 置信度 0.82
• Insights into the analysis of microbial communities in fermented foods from the perspective of DNA-based techniques.
  The quality, flavor, and stability of fermented foods depend on the microbial community. However, microbial dynamics are difficult to observe directly, leading to limited control over fermentation. High-throughput sequencing is a revolutionary tool for microbi…
  pubmed Zhou H, Yan L, Zhang L, Wang R 等 2026 Oct 31 置信度 0.82
• Off-flavor formation in legume protein ingredients: Linking molecular origins, processing-induced transformations, and mitigation strategies.
  The growing demand for sustainable protein sources has accelerated the integration of legume proteins into plant-based foods; however, their widespread acceptance remains limited by undesirable off-flavors, which are characteristically described as beany, gras…
  pubmed Opazo-Navarrete M, Bravo-Reyes C, Chacón-Fuentes M, Burgos-Díaz C 等 2026 Oct 31 置信度 0.82
• A review: Three-gate framework for strain-level safety assessment of Bacillus cereus in food systems.
  Bacillus cereus occupies an unusual position in food systems because individual strains may cause emetic intoxication, diarrhoeal toxicoinfection and spoilage, whereas selected strains have been investigated for agricultural, feed and food-biotechnology functi…
  pubmed Lei Y, Tang Y, Wei E, Liao Y 等 2026 Oct 31 置信度 0.82
• Tumour-infiltrating lymphocytes and breast radiotherapy: perspectives from the International Immuno-Oncology Biomarker Working Group.
  Tumour-infiltrating lymphocytes (TILs) are prognostic and predictive biomarkers in breast cancer. High pre-treatment TILs are associated with a favourable prognosis and improved response to systemic therapies. However, the role of TILs in mediating response to…
  pubmed Gunster JLB, Tramm T, Machiels M, Demaria S 等 2026 Sep 置信度 0.82
• Sitosterolemia: evolving strategies for earlier diagnosis.
  Sitosterolemia is a rare autosomal recessive lipid disorder caused by biallelic pathogenic variants in ABCG5 or ABCG8, resulting in excessive intestinal absorption and impaired biliary excretion of plant sterols. Although historically considered exceptionally …
  pubmed Genoux A, Jamme T, Martinez LO 2026 Aug 19 置信度 0.82
• Comparative efficacy and safety of rosuvastatin versus atorvastatin after acute ischemic stroke or transient ischemic attack: A systematic review and exploratory meta-analysis.
  Acute ischemic stroke (AIS) and transient ischemic attack (TIA) are leading causes of mortality and disability. High-intensity statins are central to secondary prevention, with guidelines recommending atorvastatin or rosuvastatin; however, comparative evidence…
  pubmed Cueva-Cañola LE, Beltran-De la Fuente AC, Ramírez Navarro DI, Carrión-Cuéllar AG 等 2026 Aug 24 置信度 0.82
• Defining the potential role of the mineralocorticoid receptor in musculoskeletal health and bone crosstalk with other tissues.
  Excessive mineralocorticoid receptor (MR) activation in the heart and vasculature leads to pathological effects such as extracellular matrix accumulation, oxidative stress, and sustained inflammation. While MR's role in cardiovascular and renal systems is well…
  pubmed Bensreti H, Shaver JC, Yearwood CL, Alhamad DW 等 2026 Aug 24 置信度 0.82
• Exploring genetic diversity in genome-wide association studies and polygenic risk scores in the admixed Brazilian population.
  The Brazilian population has a complex genetic background resulting from admixture of Native American, African, and European ancestries. This review examines how such diversity influences the findings of genome-wide association studies and the performance of p…
  pubmed Molck MC, Santos LHBD, Oliveira TC, Lopes-Cendes I 2026 置信度 0.82
• Systematic analysis of global O-serotype prevalence of neonatal extraintestinal pathogenic Escherichia coli: A protocol integrating previous research and bioinformatics databases.
  Neonatal extraintestinal pathogenic Escherichia coli (ExPEC) severe threat to newborn health. O antigen is a highly variable component of lipopolysaccharide, serves as the main phenotypic marker for serotyping, and represents a promising target for vaccination…
  pubmed Zhang D, Zou P, Xiao R, Li J 等 2026 置信度 0.82
• Current perspectives on demyelination and associated uveitis: From pathogenesis to biological therapies.
  Uveitis associated with demyelinating diseases, particularly multiple sclerosis (MS), has gained increasing attention in recent years. Advances in diagnostic modalities, such as the widespread use of brain magnetic resonance imaging, have facilitated deeper in…
  pubmed Agarwal A, Mubashir A, Mittal SO 2026 Aug 24 置信度 0.82
• cGAS-STING signaling in aging and age-related diseases: therapeutic promise and precaution.
  Endogenous cytoplasmic DNA (cytoDNA) is increasingly recognized as a mediator of tissue dysfunction and disease progression during aging. As a major cytosolic DNA-sensing pathway, the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway …
  pubmed Xu Y, Wu W, Guo Y, Wang W 等 2026 Aug 24 置信度 0.82
• Comprehensive Genomic Analysis in Hereditary Adrenal and Extra-Adrenal Paragangliomas.
  Adrenal and extra-adrenal paragangliomas (PPGLs) are highly heritable non-epithelial neuroendocrine neoplasms. Through a retrospective chart review of 110 individuals diagnosed with PPGLs at the University Health Network in Toronto, Canada (2011-2023), we char…
  pubmed Purnaghshband H, Tuzlali E, Deka KB, Bruce JP 等 2026 Aug 24 置信度 0.82
• Evolutionary co-option of endogenous retroviruses: syncytins as regulators of placental development and disease.
  Syncytins are envelope proteins of retroviral origin that have been evolutionarily co-opted to play essential roles in placental biology. Primarily recognized for mediating the fusion of cytotrophoblasts into the syncytiotrophoblast, a multinucleated epitheliu…
  pubmed Gul A, Sahoo OS, Kashyap N, Singh S 等 2026 Aug 24 置信度 0.82
• Multimodal artificial intelligence in prostate cancer: integrating multiparametric MRI with clinicopathological, molecular, and functional imaging data.
  Multimodal artificial intelligence (AI) is reshaping prostate cancer imaging by moving beyond MRI-only algorithms toward models that integrate multiparametric MRI (mpMRI) with clinical variables, pathology, genomics, ultrasound, and prostate-specific membrane …
  pubmed Fujiwara M, Yoshida S, Banerjee I, Arita Y 等 2026 Aug 24 置信度 0.82
• Role of liquid biopsy in the multimodal assessment and treatment of esophageal cancer: a surgical perspective.
  Esophageal cancer (EC) remains a highly lethal malignancy, characterized by late diagnosis, early systemic dissemination, and high recurrence rates. Conventional diagnostic and surveillance strategies have limited sensitivity for early disease detection and mi…
  pubmed Aiolfi A, Bona D, Rausa E, Tichà V 等 2026 Aug 24 置信度 0.82
• Dissecting the dsDNA viral packaging machinery: structural evolution and potential for therapeutics.
  Some double-stranded DNA viruses, such as herpesviruses and bacteriophages, utilize a powerful molecular motor to package DNA into their capsids to liquid-crystalline density. The motor is composed of large and small terminase subunits that bind to a portal co…
  pubmed Leroux MN, Teschke CM 2026 Aug 24 置信度 0.82
• Fatty acid composition and genetic associations in breast muscle of Kaijiang Sheldrake ducks.
  1. Fatty acid (FA) composition determines the nutritional value of duck meat. Systematic characterisation of FA profiles in indigenous breeds, such as the certified Kaijiang Sheldrake, is essential for genetic improvement of meat quality.2. This study used gas…
  pubmed Yang Z, Ren J, Wang L, Li L 等 2026 Aug 24 置信度 0.82
• Recent Advances (2020-2025) in Estrogen and ER-Positive Breast Cancer: Receptor Signaling, Tumor Microenvironment, Endocrine Therapy Resistance and Innovative Treatment Strategies-A Comprehensive Review.
  Estrogen receptor-positive (ER+) breast cancer accounts for 70-80% of all invasive breast malignancies worldwide and remains the dominant subtype driving rising global breast cancer incidence, representing a major clinical burden in China with a 2.84% annual a…
  pubmed Zhao J, Li D, Yang S, Ma X 2026 置信度 0.82
• Precision Diagnostics in Age-Related Hearing Loss: Emerging Molecular Biomarkers for Early Detection and Targeted Prevention.
  Age-related hearing loss (ARHL) is a prevalent neurosensory impairment. Traditional audiometry is post-symptomatic, fundamentally failing to capture the molecular deterioration that precedes clinical hearing decline by years. To address this gap, the clinical …
  pubmed Xia Z, Lin C, Wu Y, Liu H 等 2026 置信度 0.82
• The Impact of Microbial Toxins on NRF2 Signaling, Focusing on Stem Cells: Mechanisms and Therapeutic Potential.
  NF-E2-related factor 2 (NRF2) is a key transcription factor that regulates antioxidant response element (ARE)-driven genes, protecting cells from oxidative damage. Microbial toxins, through mechanisms, such as oxidative stress induction, can activate or inhibi…
  pubmed Darvishi M, Halabian R, Kachuei R 2026 Aug 4 置信度 0.82
• Advances in the Development of Antigens for the Most Prevalent Hepatitis for Biotechnological Applications.
  Despite numerous advances in prevention and diagnosis, viral hepatitis remains a serious global public health problem, exacerbated by underreporting of cases and limited access of vulnerable populations to accurate diagnostic methods. These infections, often a…
  pubmed Barcelos ICDS, Xavier SR, Cassiano CSS, Gandra IB 等 2026 Aug 4 置信度 0.82
• CRISPR-CAS9-Mediated Genetic Enhancement and Metabolic Engineering of Medicinal Crops: An Integrative Review.
  This descriptive review comprehensively examines recent advances in the genetic improvement of medicinal plants through the application of CRISPR-Cas9 genome-editing technology, highlighting its transformative potential in biotechnology and pharmacognosy. The …
  pubmed Soni L, Singhai H, Rathee S, Soni S 等 2026 Aug 3 置信度 0.82
• Innovative Insights into Osteosarcoma: Unraveling the Role of LncRNAs, miRNAs, and CircRNAs in Tumorigenesis and Therapeutic Resistance.
  Osteosarcoma (OS) is the most common form of primary bone malignancy, characterized by the production of osteoid tissue and contributing significantly to cancer-related mortality in both pediatric and adult populations. The etiology of OS remains multifactoria…
  pubmed Yeganeh A, Ghorbanlo M, Kazemi S, Emami Meybodi T 等 2026 Aug 3 置信度 0.82
• Epidemiological and Operational Constraints on the Feasibility of Peste des Petits Ruminants Eradication Target by 2030: Necessity for a New Pragmatic Road Map.
  Peste des petits ruminants (PPR) remains a major constraint to small ruminant production and food security, and a global eradication target for 2030 have been set by FAO/WOAH. This review analyses recent evidence on the feasibility of that target by integratin…
  pubmed Yeşilbağ K, Yaşar M 2026 置信度 0.82
• Chemical and Structural Engineering of Guide RNAs for Precision Genome Editing: From Design Principles to Clinical Applications.
  CRISPR-Cas9 has revolutionised genome editing by enabling efficient and programmable modification of defined DNA sequences, with guide RNAs (gRNAs) serving as indispensable elements that direct Cas9 to specific genomic loci. Initially regarded as auxiliary com…
  pubmed Kawamata M, Niwa S, Suzuki A 2026 Aug 置信度 0.82
• Heterocyclic Scaffolds in PARP-1 Inhibition: An Emerging Strategy for Targeted Anticancer Therapy.
  Poly (ADP-ribose) polymerase-1 (PARP-1) is a key regulator of DNA repair, genomic stability, and programmed cell death. PARP-1 inhibition induces synthetic lethality in homologous recombination-deficient tumors, particularly those with BRCA mutations. Firstgen…
  pubmed Balachandran H, Byran G, Karri VVSR, Murugesan SK 等 2026 Aug 6 置信度 0.82
• Plant-Microbiome Interactions for Rhizosphere Health: A Three-Step Framework for Crop Resilience.
  The rhizosphere is a key ecological niche where plants interact with microorganisms, and its health directly affects plant growth, development, and disease resistance. Existing theories have laid an important foundation for understanding plant-microbe interact…
  pubmed Qiu W, Tang X, Shen Q, Yuan J 2026 Aug 23 置信度 0.82
• Responders Vs. Non-Responders or How to Predict the Response to GLP-1 or GLP-1/GIP Receptor Agonist Therapy.
  Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and dual GLP-1/GIP receptor agonists have transformed the pharmacological management of type 2 diabetes (T2D) and obesity, yet substantial interindividual variability in treatment response remains a defining…
  pubmed Kuryłowicz A, Czupryniak L 2026 Aug 23 置信度 0.82
• Genome-wide association study of image-based emphysema scoring in the Swedish CArdioPulmonary bioImage Study (SCAPIS) suggests two new risk loci in smokers.
  Despite the high prevalence and clinical significance of emphysema, few genetic risk loci have been consistently replicated. We conducted a genome-wide association study (GWAS) of CT-based emphysema, with a particular focus on non-smoking-related genetic deter…
  pubmed Nyberg F, Lundmark P, Blomberg A, Dekkers K 等 2026 Aug 8 置信度 0.82
• Glycosylase Base Editors: New Tools for Genome Editing.
  Genome editing using the CRISPR/Cas9 system has become a staple of modern genome manipulation. In its original form, editing involved introducing double-strand breaks into DNA, which can cause genomic instability. The appearance of the first bas…
  pubmed Kulishova LM, Zharkov DO 2026 Jul 置信度 0.82
• Extrachromosomal DNA in Oncology: History of Discovery, Research Methods, and Current Perspectives.
  Extrachromosomal DNA (ecDNA) refers to circular DNA molecules without centromeres that are often found in the nuclei of cancer cells. The presence of ecDNA is associated with the development of drug resistance and poor disease prognosis. Although ecDNA was dis…
  pubmed Mukhina VS, Favorov AV 2026 Jul 置信度 0.82
• Exploring the dissociation-binge eating relationship in eating disorders: a scoping review.
  Binge eating (BE) is a core symptom across multiple eating disorders (ED), yet differences in dissociative experiences between ED subtypes-and the psychological processes linking them-remain insufficiently understood. This scoping review synthesized evidence o…
  pubmed Baudin G, Bagdasarian A, Ribadier A, El Hage W 等 2026 Aug 23 置信度 0.82
• The Genetic Architecture of Chronic Cough: From Sensory Hypersensitivity to Treatable Trait.
  Chronic cough is a prevalent global clinical disorder with substantial quality-of-life impairment, and refractory cases remain a major unmet medical need. Cough hypersensitivity syndrome is the core pathological mechanism of chronic cough, and growing genetic …
  pubmed Dong R, Zhang M, Morice AH 2026 Aug 23 置信度 0.82
• Novel cell markers with altered expression in brain aging and Alzheimer's disease: A review.
  Aging and Alzheimer's disease are complex processes marked by continuous neuronal loss, disrupted neural networks, and cognitive decline. The past decade has seen advances in genomics, proteomics, and single-cell RNA sequencing, enabling the discovery of cellu…
  pubmed Alobu EJ, Uchewa OO, Ibegbu AO 2026 Dec 置信度 0.82
• Using (19)F NMR to quantify enthalpy-entropy compensation in protein-protein interactions.
  Protein structural, stability, and functional equilibria are sensitive to the solution environment and governed by enthalpic and entropic contributions. NMR spectroscopy of suitably labeled- or isotopically enriched-samples provides a powerful tool for quantif…
  pubmed Redvanly TW, Pielak GJ 2027 Feb 置信度 0.82
• Left Ventricular Thrombus Despite Prescribed Direct Oral Anticoagulant Therapy in Chronic Heart Failure With Reduced Ejection Fraction: A Case Report and Review of Risk Stratification.
  Left ventricular thrombus (LVT) remains a clinically important complication associated with increased risks of systemic thromboembolism, ischemic stroke, and adverse cardiovascular outcomes. The optimal duration of anticoagulation&#xa0…
  pubmed Ayana G, Garcia Reinoso L, Keraga B, Conde I 等 2026 Jul 置信度 0.82
• Genome-enabled breeding of taro and other edible aroids: an evidence-based review.
  Edible aroids are clonally propagated crops in which genomic resources have accumulated faster than breeder-ready tools, with evidence concentrated in taro ( Colocasia esculenta ). We used a structured critical-review design with reproducible searches of PubMe…
  pubmed Cai X, He F 2026 Sep 置信度 0.82
• Strategic roadmap for delivery of clinical trials in rare childhood central nervous system (CNS) tumours: a multi-stakeholder consensus.
  Rare paediatric central nervous system (CNS) tumours comprise a biologically-heterogeneous group of low-incidence diseases that present significant challenges to both therapeutic development and clinical research, limiting the availability of high-quality evid…
  pubmed Adamski J, Apps JR, Depani S, Hill RM 等 2026 Aug 22 置信度 0.82
• From water to land: evolution of tRNA gene repertoires in photosynthetic organisms.
  Photosynthetic eukaryotes have undergone evolutionary shifts from aquatic to terrestrial habitats, accompanied by changes in genome organization and gene regulation. Yet, the evolution of transfer RNA (tRNA) gene repertoires has received limited attention desp…
  pubmed Hummel G, Pflieger D, Berr A, Drouard L 2026 Aug 22 置信度 0.82
• Ergothioneine as an Emerging Food-Derived Bioactive Compound Protecting against Age-related Diseases: Issues Needing More Research.
  Ergothioneine (ET) is a chemically-stable, tasteless, odourless, highly water-soluble diet-derived compound that is avidly absorbed and retained by the human body using a selective transporter, organic cation transporter novel 1, OCTN1 (often called the ET tra…
  pubmed Halliwell B 2026 Aug 22 置信度 0.82
• Systematic review of the mutations in the active antigenic site Ø of the prefusion F protein of the Respiratory Syncytial Virus (RSV) following the implementation of monoclonal antibody prophylaxis.
  Monoclonal antibody (mAb) nirsevimab, which targets the antigenic site Ø of the prefusion F protein (pre-F) of RSV, was introduced for RSV prophylaxis in several countries.
  pubmed Berikopoulou MM, Tatsi EB, Siahanidou T, Michos A 2026 Aug 22 置信度 0.82
• From genotype to outcome in optic pathway gliomas: Biology, biomarkers, targeted therapy, and future directions.
  Optic pathway gliomas (OPG) are a heterogeneous group of low-grade tumors that primarily affect the pediatric population and are frequently associated with neurofibromatosis type 1. Although typically low-grade, OPG can exhibit highly variable clinical behavio…
  pubmed Angulo-De La Cruz EJ, Magaña-Curiel G, Aguirre-Guillén RL, Rodríguez-Machuca VU 2026 Aug 14 置信度 0.82
• Precision Pancreatic Cancer Care: From Early Detection to Adaptive Precision Oncology.
  Pancreatic ductal adenocarcinoma (PDAC) remains highly lethal, and genome-centric precision oncology shows limited impact due to low actionable alterations and high heterogeneity.
  pubmed Okabayashi T, Tabuchi M, Tokumaru T, Uemura S 等 2026 Aug 22 置信度 0.82
• Remodeling the Immune Landscape: How Obesity-Induced SASPs Create a Pro-Tumorigenic Niche.
  Obesity is a potent risk factor for cancer, primarily driven by a state of chronic inflammation. A key mechanism linking adipose tissue dysfunction to tumorigenesis is the induction of cellular senescence and the related Senescence-Associated Secretory Phenoty…
  pubmed Abd El-Fattah EE, Ngai G, Mooney R, Aboody KS 2026 Aug 22 置信度 0.82
• Melatonin in lung cancer: integrating molecular mechanisms, tumor microenvironment regulation, apoptotic signaling, and therapeutic opportunities.
  Lung cancer (LC) remains a major cause of cancer-related mortality, and current therapeutic strategies are frequently limited by treatment resistance, tumor heterogeneity, and adverse effects. Although apoptosis is a critical mechanism underlying the anticance…
  pubmed Wu J, Kang H, Huang Y, Ruan L 等 2026 Aug 22 置信度 0.82
• Plant–Microbe Interactions: Integrating Botanical and Chemical Perspectives in Rhizosphere Communication and Plant Health- A Review
  In this review paper, Plant–microbe interactions represent complex biological and chemical relationships that influence plant growth, nutrient acquisition, stress tolerance, and disease resistance. Plants interact with diverse microorganisms including bacteria…
  datacite Shashank Narayan , Ashutosh Kumar2, Dr. Neelam Kumar3 2026 置信度 0.66
• Plant–Microbe Interactions: Integrating Botanical and Chemical Perspectives in Rhizosphere Communication and Plant Health- A Review
  In this review paper, Plant–microbe interactions represent complex biological and chemical relationships that influence plant growth, nutrient acquisition, stress tolerance, and disease resistance. Plants interact with diverse microorganisms including bacteria…
  datacite Shashank Narayan , Ashutosh Kumar2, Dr. Neelam Kumar3 2026 置信度 0.66
• Hereditary Disorders in Moderate-Altitude Taif, Saudi Arabia: Molecular Genetic Evidence and a Community Genomics Research Agenda
  Abstract: - Taif is situated at approximately 1,800 m above sea level, below the conventional threshold for high altitude but sufficiently elevated to justify investigation of oxygen-sensitive phenotypes. Its community-genetics profile is also shaped by consan…
  datacite Yahya Hamed Alzahrani*, Faten A. S. Alsulaimany, Mohd Rehan, Maged Mostafa Mahmoud 等 2026 置信度 0.66 Taif; community genetics; consanguinity; hereditary disorders; genomic medicine; moderate altitude.
• Hereditary Disorders in Moderate-Altitude Taif, Saudi Arabia: Molecular Genetic Evidence and a Community Genomics Research Agenda
  Abstract: - Taif is situated at approximately 1,800 m above sea level, below the conventional threshold for high altitude but sufficiently elevated to justify investigation of oxygen-sensitive phenotypes. Its community-genetics profile is also shaped by consan…
  datacite Yahya Hamed Alzahrani*, Faten A. S. Alsulaimany, Mohd Rehan, Maged Mostafa Mahmoud 等 2026 置信度 0.66 Taif; community genetics; consanguinity; hereditary disorders; genomic medicine; moderate altitude.
• A framework to integrate innovations in invasion science for proactive management
  Invasive alien species (IAS) are a rising threat to biodiversity, national security, and regional economies, with impacts in the hundreds of billions of U.S. dollars annually. Proactive or predictive approaches guided by scientific knowledge are essential to k…
  datacite Charles B. van Rees, BK Hand, SC Carter, C Bargeron 等 2025 置信度 0.66 Biological sciences
• A framework to integrate innovations in invasion science for proactive management
  Invasive alien species (IAS) are a rising threat to biodiversity, national security, and regional economies, with impacts in the hundreds of billions of U.S. dollars annually. Proactive or predictive approaches guided by scientific knowledge are essential to k…
  datacite van Rees, Charles B., Hand, BK, Carter, SC, Bargeron, C 等 2025 置信度 0.66 Biological sciencesFOS: Biological sciences
• Navigating Nature's Pharmacy: Charting the Natural Product Chemical Space for Modern Drug Discovery
  Natural products (NPs) are an indispensable source of therapeutic agents, occupying a privileged and structurally diverse region of the Biologically Relevant Chemical Space (BioReCS) that is underexplored by synthetic compound libraries. This comprehensive rev…
  datacite natural product chemistry 2026 置信度 0.66 natural productsdrug discoverychemical spaceBioReCShigh-throughput screening
• Navigating Nature's Pharmacy: Charting the Natural Product Chemical Space for Modern Drug Discovery
  Natural products (NPs) are an indispensable source of therapeutic agents, occupying a privileged and structurally diverse region of the Biologically Relevant Chemical Space (BioReCS) that is underexplored by synthetic compound libraries. This comprehensive rev…
  datacite natural product chemistry 2026 置信度 0.66 natural productsdrug discoverychemical spaceBioReCShigh-throughput screening
• Recent advances in Cannabis sativa genomics research
  Cannabis (Cannabis sativa L.) is one of the oldest cultivated plants purported to have unique medicinal properties. However, scientific research of cannabis has been restricted by the Single Convention on Narcotic Drugs of 1961, an international treaty that pr…
  datacite Bhavna Hurgobin, Muluneh Oli, Matthew Welling, Monika Doblin 等 2021 置信度 0.66 Biological sciencesPlant biologyEnvironmental sciencesClimate change impacts and adaptationEcological applications
• Recent advances in Cannabis sativa genomics research
  Cannabis (Cannabis sativa L.) is one of the oldest cultivated plants purported to have unique medicinal properties. However, scientific research of cannabis has been restricted by the Single Convention on Narcotic Drugs of 1961, an international treaty that pr…
  datacite Bhavna Hurgobin, Muluneh Oli, Matthew Welling, Monika Doblin 等 2021 置信度 0.66 Biological sciencesPlant biologyEnvironmental sciencesClimate change impacts and adaptationEcological applications
• From Bench to Breakthrough: The Evolution of Modern Experimental Biochemistry
  This article provides a comprehensive overview of the evolution of modern experimental biochemistry, tracing its journey from foundational principles to today's integrated, high-throughput science. It begins by exploring the historical schism and recent synthe…
  datacite biochemical science 2026 置信度 0.66 Experimental BiochemistryEvolutionary BiochemistryCRISPR-Cas9Multi-OmicsAlphaFold
• From Bench to Breakthrough: The Evolution of Modern Experimental Biochemistry
  This article provides a comprehensive overview of the evolution of modern experimental biochemistry, tracing its journey from foundational principles to today's integrated, high-throughput science. It begins by exploring the historical schism and recent synthe…
  datacite biochemical science 2026 置信度 0.66 Experimental BiochemistryEvolutionary BiochemistryCRISPR-Cas9Multi-OmicsAlphaFold
• Uterine Fibroids
  Uterine Fibroids Article by : Deepak Avtar Singh Dilip Vishnoi Under the guidance of : Aidarbek kyzy Aidanek Abstract Uterine fibroids (leiomyomas) are the most common benign neoplasms in women, representing a monumental clinical and public health challenge. A…
  datacite Deepak, Singh, Avtar, Vishnoi, Dilip, Aidarbek kyzy Aidanek 2026 置信度 0.66
• Uterine Fibroids
  Uterine Fibroids Article by : Deepak Avtar Singh Dilip Vishnoi Under the guidance of : Aidarbek kyzy Aidanek Abstract Uterine fibroids (leiomyomas) are the most common benign neoplasms in women, representing a monumental clinical and public health challenge. A…
  datacite Deepak, Singh, Avtar, Vishnoi, Dilip, Aidarbek kyzy Aidanek 2026 置信度 0.66
• Systems-Level Dissection of Post-Acute Sequelae of COVID-19: Integrative Multi-Omics, Mitochondrial Dysfunction, Persistent Viral Reservoirs, and Precision Pharmacotherapeutic Targeting
  Background: Post-Acute Sequelae of COVID-19 (PASC), commonly referred to as Long COVID, has emerged as a complex, multisystem condition following infection with SARS-CoV-2. Patients exhibit persistent and heterogeneous symptoms affecting neurological, cardiova…
  datacite Malarkodi Velraj1, Geeta Rawat2, Ritika Kalia3, Isha Kapila4, Somesh Thapliyal5, Alka Mishra6, Rajeev Kumar7, Yash Srivastav8, Pratyush Mishra9* 2026 置信度 0.66 COVID, PASC, SARS-CoV-2, multi-omics, precision medicine
• Systems-Level Dissection of Post-Acute Sequelae of COVID-19: Integrative Multi-Omics, Mitochondrial Dysfunction, Persistent Viral Reservoirs, and Precision Pharmacotherapeutic Targeting
  Background: Post-Acute Sequelae of COVID-19 (PASC), commonly referred to as Long COVID, has emerged as a complex, multisystem condition following infection with SARS-CoV-2. Patients exhibit persistent and heterogeneous symptoms affecting neurological, cardiova…
  datacite Malarkodi Velraj1, Geeta Rawat2, Ritika Kalia3, Isha Kapila4, Somesh Thapliyal5, Alka Mishra6, Rajeev Kumar7, Yash Srivastav8, Pratyush Mishra9* 2026 置信度 0.66 COVID, PASC, SARS-CoV-2, multi-omics, precision medicine
• HOST–PATHOGEN INTERACTIONS IN TUBERCULOSIS: A MULTI-OMICS AND ARTIFICIAL INTELLIGENCE PERSPECTIVE
  Published journal article: Host–Pathogen Interactions in Tuberculosis: A Multi-Omics and Artificial Intelligence Perspective. This review discusses recent advances in understanding host–pathogen interactions in tuberculosis through multi-omics approaches and a…
  datacite Rasool, Shafqat, Nayab, Pakeeza, Rafique, Hammad, Zahid, Hamda 等 2026 置信度 0.66 TuberculosisMycobacterium tuberculosisHost–pathogen interactionsMulti-omicsArtificial intelligence
• HOST–PATHOGEN INTERACTIONS IN TUBERCULOSIS: A MULTI-OMICS AND ARTIFICIAL INTELLIGENCE PERSPECTIVE
  Published journal article: Host–Pathogen Interactions in Tuberculosis: A Multi-Omics and Artificial Intelligence Perspective. This review discusses recent advances in understanding host–pathogen interactions in tuberculosis through multi-omics approaches and a…
  datacite Rasool, Shafqat, Nayab, Pakeeza, Rafique, Hammad, Zahid, Hamda 等 2026 置信度 0.66 TuberculosisMycobacterium tuberculosisHost–pathogen interactionsMulti-omicsArtificial intelligence
• NEED OF AYURGENOMICS IN AYURVEDA: BRIDGING CLASSICAL WISDOM WITH PRECISION MEDICINE – A COMPREHENSIVE REVIEW
  Ayurveda advocates individualized healthcare through the concept of Prakruti (biological constitution), which determines an individual's physiological characteristics, disease susceptibility, therapeutic response, and overall health. Although this personalized…
  datacite 1Dr. Pratiksha Umbardand, *2Dr. Vijaya Nyahalse (Nagarale), 3Dr. Sneha Shinde 2026 置信度 0.66
• NEED OF AYURGENOMICS IN AYURVEDA: BRIDGING CLASSICAL WISDOM WITH PRECISION MEDICINE – A COMPREHENSIVE REVIEW
  Ayurveda advocates individualized healthcare through the concept of Prakruti (biological constitution), which determines an individual's physiological characteristics, disease susceptibility, therapeutic response, and overall health. Although this personalized…
  datacite 1Dr. Pratiksha Umbardand, *2Dr. Vijaya Nyahalse (Nagarale), 3Dr. Sneha Shinde 2026 置信度 0.66
• A silver bullet in a golden age of functional genomics: the impact of Agrobacterium-mediated transformation of fungi
  © The Author(s). The implementation of Agrobacterium tumefaciens as a transformation tool revolutionized approaches to discover and understand gene functions in a large number of fungal species. A. tumefaciens mediated transformation (AtMT) is one of the most …
  datacite A Idnurm, AM Bailey, TC Cairns, Candace Elliott 等 2021 置信度 0.66
• A silver bullet in a golden age of functional genomics: the impact of Agrobacterium-mediated transformation of fungi
  © The Author(s). The implementation of Agrobacterium tumefaciens as a transformation tool revolutionized approaches to discover and understand gene functions in a large number of fungal species. A. tumefaciens mediated transformation (AtMT) is one of the most …
  datacite A Idnurm, AM Bailey, TC Cairns, Candace Elliott 等 2021 置信度 0.66
• vschan2/multivistechs-analysis: v0.1.0 - Initial Release
  What's Included Scripts: pairwise_analysis.py - main CLI tool (interactive mode + --utility {1,2,3} flags) for building the visualization-technique co-occurrence network and generating analysis outputs Utilities: Utility 1: Network statistics (density, degree …
  datacite vschan2 2026 置信度 0.66
• Decentralized Epistemic Rollback Fabric: Proof-Graded Causal Revocation, Clean Replay, and Recontamination Prevention for Cross-Domain Agent Networks
  Distributed agent and research systems embed revoked or unlawful data into papers, models, and clinical decision aids; ordinary software rollback does not remove epistemic descendants. Existing practice relies on slow, incomplete manual retraction notices. We …
  datacite Haxhijaha, Agim 2026 置信度 0.66 epistemic-rollbackcausal-revocationagent-memory-unlearningclean-replayrecontamination-prevention
• Decentralized Epistemic Rollback Fabric: Proof-Graded Causal Revocation, Clean Replay, and Recontamination Prevention for Cross-Domain Agent Networks
  Distributed agent and research systems embed revoked or unlawful data into papers, models, and clinical decision aids; ordinary software rollback does not remove epistemic descendants. Existing practice relies on slow, incomplete manual retraction notices. We …
  datacite Haxhijaha, Agim 2026 置信度 0.66 epistemic-rollbackcausal-revocationagent-memory-unlearningclean-replayrecontamination-prevention