-
crossref
2025-11-21T19:32:09Z
置信度 0.70
-
crossref
2022-04-07T17:01:23Z
置信度 0.70
-
crossref
2023-10-12T18:23:38Z
置信度 0.70
-
crossref
Jay Kulsh
2023-11-15T03:54:50Z
置信度 0.70
-
crossref
2024-03-22T17:18:30Z
置信度 0.70
-
crossref
2024-03-22T17:18:30Z
置信度 0.70
-
crossref
Jean Clairambault
2024-01-14T16:34:50Z
置信度 0.70
-
crossref
2024-07-16T07:31:05Z
置信度 0.70
-
crossref
2026-05-06T21:02:19Z
置信度 0.70
-
crossref
Konieczny Leszek
2023-11-30T05:22:28Z
置信度 0.70
-
crossref
2024-07-16T07:31:05Z
置信度 0.70
-
crossref
Ajit Singh
2021-02-25T13:10:13Z
置信度 0.70
-
crossref
Salah Aljanabi
2004-05-19T00:22:14Z
置信度 0.70
-
crossref
2024-01-29T09:53:30Z
置信度 0.70
-
crossref
2017-05-03T17:25:15Z
置信度 0.70
-
crossref
Thomas Seyfried
2023-12-01T08:28:36Z
置信度 0.70
-
crossref
2024-03-22T17:18:30Z
置信度 0.70
-
New developments in plant sciences have transformed biotechnology, sustainable crop production, and modern agriculture. The fields of molecular biology, tissue culture, genomics, proteomics, and CRISPR-based gene editing have emerged as potent instruments for …
datacite
Harshika Kamlesh Pardeshi
2026
置信度 0.66
Molecular Biology, Plant Tissue Culture, Genomics, Proteomics, CRISPR, Gene Editing.
-
Public attention to new technologies typically arrives years after their first public emergence — yet this lag has rarely been measured systematically. This work introduces the Zorthex Public Attention Diffusion Lag (L), an empirical indicator defined as the n…
datacite
Santi, Renato
2026
置信度 0.66
Technology/trendstechnology diffusiongoogle trendsmRNA VaccinesCRISPR-Cas Systems
-
Public attention to new technologies typically arrives years after their first public emergence — yet this lag has rarely been measured systematically. This work introduces the Zorthex Public Attention Diffusion Lag (L), an empirical indicator defined as the n…
datacite
Santi, Renato
2026
置信度 0.66
Technology/trendstechnology diffusiongoogle trendsmRNA VaccinesCRISPR-Cas Systems
-
Viral vectors have become the backbone of delivery strategies in modern gene therapy, offering biologically robust means of transporting therapeutic transgenes and genome-editing machinery, most notably CRISPR-Cas nuclease systems, into target cells. Moving th…
datacite
Yusra A. Radeef, Zahraa Ali Abdullah, Eman Fadhel Abbas Awadh
2026
置信度 0.66
Viral vectors, gene editing, CRISPR-Cas9, analytical testing, biosafety profiling, quality control, off-target cleavage, vector titration.
-
Viral vectors have become the backbone of delivery strategies in modern gene therapy, offering biologically robust means of transporting therapeutic transgenes and genome-editing machinery, most notably CRISPR-Cas nuclease systems, into target cells. Moving th…
datacite
Yusra A. Radeef, Zahraa Ali Abdullah, Eman Fadhel Abbas Awadh
2026
置信度 0.66
Viral vectors, gene editing, CRISPR-Cas9, analytical testing, biosafety profiling, quality control, off-target cleavage, vector titration.
-
Antimicrobial resistance (AMR) has emerged as one of the gravest threats to global public health in the twenty-first century, challenging the fundamental foundations of modern clinical medicine. The progressive erosion of antibiotic efficacy across diverse pat…
datacite
Ranajeet Patil*1, Shivprasad Dhage2
2026
置信度 0.66
Antimicrobial resistance; β-lactamase; biofilm; efflux pumps; horizontal gene transfer; CRISPR-Cas; phage therapy; stewardship; multidrug resistance; carbapenemase; mobile genetic elements; One Health
-
Antimicrobial resistance (AMR) has emerged as one of the gravest threats to global public health in the twenty-first century, challenging the fundamental foundations of modern clinical medicine. The progressive erosion of antibiotic efficacy across diverse pat…
datacite
Ranajeet Patil*1, Shivprasad Dhage2
2026
置信度 0.66
Antimicrobial resistance; β-lactamase; biofilm; efflux pumps; horizontal gene transfer; CRISPR-Cas; phage therapy; stewardship; multidrug resistance; carbapenemase; mobile genetic elements; One Health
-
Interactive Data Viewer: Read, View, and Print from Day 1 Use our fully interactive viewer to view, read, and print this research data right from Day 1: https://pathmap.org/viewer.php?id=31 Artificial General Intelligence LLC Claim Evaluated: Why are frontotem…
datacite
Dungan, Joshua
2026
置信度 0.66
C9orf72 expansion_gates_from_c9orf72_expansionGene Expression Regulation_gates_to_gene_expression_regulation_gates_from_gene_expression_regulation
-
Interactive Data Viewer: Read, View, and Print from Day 1 Use our fully interactive viewer to view, read, and print this research data right from Day 1: https://pathmap.org/viewer.php?id=31 Artificial General Intelligence LLC Claim Evaluated: Why are frontotem…
datacite
Dungan, Joshua
2026
置信度 0.66
C9orf72 expansion_gates_from_c9orf72_expansionGene Expression Regulation_gates_to_gene_expression_regulation_gates_from_gene_expression_regulation
-
This article presents a detailed examination of human induced pluripotent stem cell (hiPSC) technology as a transformative platform for patient-specific disease modeling, drug discovery, and regenerative medicine. It begins by tracing the history of cellular r…
datacite
regenerative medicine science
2026
置信度 0.66
human induced pluripotent stem cellshiPSCdisease modelingsomatic cell reprogrammingYamanaka factors
-
This article presents a detailed examination of human induced pluripotent stem cell (hiPSC) technology as a transformative platform for patient-specific disease modeling, drug discovery, and regenerative medicine. It begins by tracing the history of cellular r…
datacite
regenerative medicine science
2026
置信度 0.66
human induced pluripotent stem cellshiPSCdisease modelingsomatic cell reprogrammingYamanaka factors
-
Macrophages are highly plastic innate immune cells capable of adopting distinct functional phenotypes in response to microenvironmental cues, a process known as polarization. This comprehensive review explores the foundational M1 and M2 paradigm, where M1 macr…
datacite
inflammation study
2026
置信度 0.66
Macrophage polarizationChronic inflammationM1/M2 paradigmSignaling pathwaysMetabolic reprogramming
-
Macrophages are highly plastic innate immune cells capable of adopting distinct functional phenotypes in response to microenvironmental cues, a process known as polarization. This comprehensive review explores the foundational M1 and M2 paradigm, where M1 macr…
datacite
inflammation study
2026
置信度 0.66
Macrophage polarizationChronic inflammationM1/M2 paradigmSignaling pathwaysMetabolic reprogramming
-
This SOP describes a clinical research workflow for the "Althea" (Precision Oncology Framework) CRISPR TTP architecture, integrating: CRISPR/Cas9 editing of dendritic cells. GMP-grade dendritic cell production. Theranostic nanoparticle (TTP) formulation and de…
datacite
Alexey Mikhailovich Burlai
2025
置信度 0.66
CRISPR TTP architectureDendritic cell vaccinationFocused Ultrasound activationEwing SarcomaAI-driven immunotherapy
-
This SOP describes a clinical research workflow for the "Althea" (Precision Oncology Framework) CRISPR TTP architecture, integrating: CRISPR/Cas9 editing of dendritic cells. GMP-grade dendritic cell production. Theranostic nanoparticle (TTP) formulation and de…
datacite
Alexey Mikhailovich Burlai
2025
置信度 0.66
CRISPR TTP architectureDendritic cell vaccinationFocused Ultrasound activationEwing SarcomaAI-driven immunotherapy
-
The period from 2024 to early 2026 represents a critical inflection point in biomedical research and precision medicine, driven by the deep integration of large-scale biological data with advanced artificial intelligence (AI) architectures. This era marks a tr…
datacite
Fahim Halim Khan
2026
置信度 0.66
-
The period from 2024 to early 2026 represents a critical inflection point in biomedical research and precision medicine, driven by the deep integration of large-scale biological data with advanced artificial intelligence (AI) architectures. This era marks a tr…
datacite
Fahim Halim Khan
2026
置信度 0.66
-
This paper analyses the challenges Artificial Intelligence (AI) is helping solve in the field of xenotransplantation. Xenotransplantation is the field of transplanting animal organs into humans. Due to the global shortage of transplantable human organs, xenotr…
datacite
Bhagat H.M.
2026
置信度 0.66
-
This paper analyses the challenges Artificial Intelligence (AI) is helping solve in the field of xenotransplantation. Xenotransplantation is the field of transplanting animal organs into humans. Due to the global shortage of transplantable human organs, xenotr…
datacite
Bhagat H.M.
2026
置信度 0.66
-
The emergence of CRISPR-Cas9 gene-editing technology has revolutionised the field of biotechnology, offering unprecedented possibilities for curing genetic diseases, enhancing agricultural productivity, and potentially altering human evolution. However, these …
datacite
Dr Joydeb Patra, Dr Itishree Panda, Dr Itishree Panda
2026
置信度 0.66
-
The emergence of CRISPR-Cas9 gene-editing technology has revolutionised the field of biotechnology, offering unprecedented possibilities for curing genetic diseases, enhancing agricultural productivity, and potentially altering human evolution. However, these …
datacite
Dr Joydeb Patra, Dr Itishree Panda, Dr Itishree Panda
2026
置信度 0.66
-
Condensins are protein complexes imperative for the individualisation and rigidity of mitotic chromatids. The functions of these highly conserved proteins are essential for the successful inheritance of genetic material during cell division. Mutations in conde…
datacite
Brisbane, Jennifer M.
2023
置信度 0.66
condensin II subunitNCAPH2mitotic chromatidsabnormal ploidyploidy
-
SORCS2 and SORLA are members of the Vps10p-domain receptor family, which comprises five multifunctional neuronal receptors. All family members are involved in intracellular sorting and trafficking of various neurotrophic factors and their precursor forms, as w…
datacite
Gospodinova, Katerina Ognyanova
2020
置信度 0.66
sortilinsSORLASORCS2Vps10p-domain receptorsDSB formation
-
Crop improvement programmes are under unprecedented pressure due to the ever-growing demand for food, climate change, new pests and diseases, and decreasing natural resource. While conventional breeding is essential, it can take long time to combine desirable …
datacite
Dr. Neha Belsariya1, Dr. Mariyappan S B2*, Dr. Biju Sidharthan3 and Rughwinder Kaur4
2026
置信度 0.66
-
Crop improvement programmes are under unprecedented pressure due to the ever-growing demand for food, climate change, new pests and diseases, and decreasing natural resource. While conventional breeding is essential, it can take long time to combine desirable …
datacite
Dr. Neha Belsariya1, Dr. Mariyappan S B2*, Dr. Biju Sidharthan3 and Rughwinder Kaur4
2026
置信度 0.66
-
CRISPR/Cas9-mediated homology-directed repair (HDR) allows precise gene editing, but its efficiency remains low for certain cell types, such as human induced pluripotent stem cells (hiPSCs). In this study, we aimed to introduce the CTNNA1: c.2023C>T (p.Q675*) …
datacite
Oliveira, Carla
2026
置信度 0.66
CRISPR/Cas9HDRhiPSCsprecise genetic editingkaryotyping
-
CRISPR/Cas9-mediated homology-directed repair (HDR) allows precise gene editing, but its efficiency remains low for certain cell types, such as human induced pluripotent stem cells (hiPSCs). In this study, we aimed to introduce the CTNNA1: c.2023C>T (p.Q675*) …
datacite
Oliveira, Carla
2026
置信度 0.66
CRISPR/Cas9HDRhiPSCsprecise genetic editingkaryotyping
-
Parkinson’s disease (PD) is a neurodegenerative disorder caused by complex genetic and environmental factors. Genome-edited human pluripotent stem cells (hPSCs) offer the uniique potential to advance our understanding of PD etiology by providing disease-releva…
datacite
Busquets Figueras, Oriol, Li, Hanqin, Syed, Khaja Mohieddin, Alvarez Jerez, Pilar 等
2026
置信度 0.66
-
Parkinson’s disease (PD) is a neurodegenerative disorder caused by complex genetic and environmental factors. Genome-edited human pluripotent stem cells (hPSCs) offer the uniique potential to advance our understanding of PD etiology by providing disease-releva…
datacite
Busquets Figueras, Oriol, Li, Hanqin, Syed, Khaja Mohieddin, Alvarez Jerez, Pilar 等
2026
置信度 0.66
-
Background- Candida auris is an emerging multidrug-resistant (MDR) fungal pathogen that poses a significant global health threat, particularly in healthcare settings. Its ability to cause invasive infections, coupled with its resistance to multiple antifungal …
datacite
Dr. Anjali Maria, Dr. Mercy john idikula, Dr. Teena Jacob
2026
置信度 0.66
Candida auris; CRISPR diagnostics; SHERLOCK; DETECTR; Cas12; Cas13; molecular diagnostics; antifungal resistance; outbreak surveillance; point-of-care testing; nanotechnology; fungal infection control.
-
Background- Candida auris is an emerging multidrug-resistant (MDR) fungal pathogen that poses a significant global health threat, particularly in healthcare settings. Its ability to cause invasive infections, coupled with its resistance to multiple antifungal …
datacite
Dr. Anjali Maria, Dr. Mercy john idikula, Dr. Teena Jacob
2026
置信度 0.66
Candida auris; CRISPR diagnostics; SHERLOCK; DETECTR; Cas12; Cas13; molecular diagnostics; antifungal resistance; outbreak surveillance; point-of-care testing; nanotechnology; fungal infection control.
-
EVOLUTION OF MICRO-ORGANISM AND MACRO-ORGANISM: AI MODEL.
datacite
Venkatesan
2026
置信度 0.66
Biological EvolutionArtificial intelligence
-
EVOLUTION OF MICRO-ORGANISM AND MACRO-ORGANISM: AI MODEL.
datacite
Venkatesan
2026
置信度 0.66
Biological EvolutionArtificial intelligence
-
Pythia is a tool for designing CRISPR-Cas9 knock-in strategies for endogenous C-terminal protein tagging, which ranks candidate sgRNA/repair-template combinations based on predicted editing outcomes. This dataset contains precomputed Pythia predictions across …
datacite
Yamamoto, Taiyo, Röck, Ruth, Vromant, Koen, Lienkamp, Soeren 等
2026
置信度 0.66
-
Pythia is a tool for designing CRISPR-Cas9 knock-in strategies for endogenous C-terminal protein tagging, which ranks candidate sgRNA/repair-template combinations based on predicted editing outcomes. This dataset contains precomputed Pythia predictions across …
datacite
Yamamoto, Taiyo, Röck, Ruth, Vromant, Koen, Lienkamp, Soeren 等
2026
置信度 0.66
-
CRISPR-Cas9 gene editing efficiency varies over 100-fold depending on the 20-nucleotide guide RNA (gRNA) sequence,yet the molecular determinants of on-target activity remain incompletely understood, making computational guide designessential for experimental s…
datacite
Erik Hansen
2024
置信度 0.66
-
CRISPR-Cas9 gene editing efficiency varies over 100-fold depending on the 20-nucleotide guide RNA (gRNA) sequence,yet the molecular determinants of on-target activity remain incompletely understood, making computational guide designessential for experimental s…
datacite
Erik Hansen
2024
置信度 0.66
-
Gene editing represents one of the most transformative biotechnologies of the 21st century, offering unprecedented precision in modifying DNA to treat genetic diseases, enhance agricultural productivity, and potentially alter the trajectory of human evolution.…
datacite
Dr Saloni Jain, Jawed Akhtar, Ramdev Siyag, Mohd Danis 等
2026
置信度 0.66
CRISPR-Cas9, Gene Editing, Casgevy, Sickle Cell Disease, Base Editing, Personalized Medicine, Bioethics, FDA Approval, Genetic Therapy, Off-Target Effects, Germline Editing, Therapeutic Genome Editing
-
Gene editing represents one of the most transformative biotechnologies of the 21st century, offering unprecedented precision in modifying DNA to treat genetic diseases, enhance agricultural productivity, and potentially alter the trajectory of human evolution.…
datacite
Dr Saloni Jain, Jawed Akhtar, Ramdev Siyag, Mohd Danis 等
2026
置信度 0.66
CRISPR-Cas9, Gene Editing, Casgevy, Sickle Cell Disease, Base Editing, Personalized Medicine, Bioethics, FDA Approval, Genetic Therapy, Off-Target Effects, Germline Editing, Therapeutic Genome Editing
-
Data files for the above publication. ABSTRACT Natural environments harbor a vast and largely unexplored microbial biodiversity. Among these, the Mar Menor, Europe's largest hypersaline coastal lagoon located in southeastern Spain, represents a unique ecosyste…
datacite
Toro Pineda, Ivan, Domínguez Huerta, Guillermo, Cabello Pérez, Ana María, Coutinho, Felipe 等
2026
置信度 0.66
-
Data files for the above publication. ABSTRACT Natural environments harbor a vast and largely unexplored microbial biodiversity. Among these, the Mar Menor, Europe's largest hypersaline coastal lagoon located in southeastern Spain, represents a unique ecosyste…
datacite
Toro Pineda, Ivan, Domínguez Huerta, Guillermo, Cabello Pérez, Ana María, Coutinho, Felipe 等
2026
置信度 0.66
-
Data files for the above publication. ABSTRACT Natural environments harbor a vast and largely unexplored microbial biodiversity. Among these, the Mar Menor, Europe's largest hypersaline coastal lagoon located in southeastern Spain, represents a unique ecosyste…
datacite
Toro Pineda, Ivan, Domínguez Huerta, Guillermo, Cabello Pérez, Ana María, Coutinho, Felipe 等
2026
置信度 0.66
-
CRISPR started as a gene editing tool and has quietly become something much broader: a programmable moleculardetection platform that can be wired into electronic devices. The trick is that certain Cas enzymes -- Cas12 and Cas13 inparticular -- do not just cut …
datacite
Eva Kovacs, Matteo Schmidt, Pierre Horvath
2024
置信度 0.66
CRISPR; Cas12; Cas13; SHERLOCK; DETECTR; biosensor; diagnostics; electrochemical; microfluidic; point-of-care; CDIQI; lateral flow; Sweden; Germany; France
-
CRISPR started as a gene editing tool and has quietly become something much broader: a programmable moleculardetection platform that can be wired into electronic devices. The trick is that certain Cas enzymes -- Cas12 and Cas13 inparticular -- do not just cut …
datacite
Eva Kovacs, Matteo Schmidt, Pierre Horvath
2024
置信度 0.66
CRISPR; Cas12; Cas13; SHERLOCK; DETECTR; biosensor; diagnostics; electrochemical; microfluidic; point-of-care; CDIQI; lateral flow; Sweden; Germany; France
-
Abstract Precise genome editing methods are essential in achieving progress in sustainable food production methods. Through targeted genetic enhancements, CRISPR-Cas platforms make transformations possible without introducing foreign DNA, so they hold great po…
datacite
SHARIAR, MD FAHIM, Md Asadur, Rahaman
2025
置信度 0.66
CRISPR-Cas SystemsGene EditingSustainable agricultureSustainable fisheries
-
Abstract Precise genome editing methods are essential in achieving progress in sustainable food production methods. Through targeted genetic enhancements, CRISPR-Cas platforms make transformations possible without introducing foreign DNA, so they hold great po…
datacite
SHARIAR, MD FAHIM, Md Asadur, Rahaman
2025
置信度 0.66
CRISPR-Cas SystemsGene EditingSustainable agricultureSustainable fisheries
-
A study published in Nucleic Acids Research applies quantum chemical descriptors—for the first time—to an artificial intelligence (AI) model that predicts the cleavage efficiency of CRISPR-Cas9 gene scissors. By analyzing large-scale E. coli and H. sapiens CRI…
datacite
inquantio
2026
置信度 0.66
quantum biology
-
A study published in Nucleic Acids Research applies quantum chemical descriptors—for the first time—to an artificial intelligence (AI) model that predicts the cleavage efficiency of CRISPR-Cas9 gene scissors. By analyzing large-scale E. coli and H. sapiens CRI…
datacite
inquantio
2026
置信度 0.66
quantum biology
-
Regenerative medicine aims to restore damaged tissues and organs through cell-based therapies, biomaterial scaffolds,and growth factor delivery. CRISPR-Cas gene editing has emerged as a transformative tool for enhancing regenerativeoutcomes by reprogramming ce…
datacite
Daniel Ivanov, Andreas Lindberg, Hugo Garcia
2023
置信度 0.66
CRISPR-Cas9; regenerative medicine; gene editing; mesenchymal stem cells; tissue engineering; cartilage repair; cardiac regeneration; epigenetic reprogramming
-
Regenerative medicine aims to restore damaged tissues and organs through cell-based therapies, biomaterial scaffolds,and growth factor delivery. CRISPR-Cas gene editing has emerged as a transformative tool for enhancing regenerativeoutcomes by reprogramming ce…
datacite
Daniel Ivanov, Andreas Lindberg, Hugo Garcia
2023
置信度 0.66
CRISPR-Cas9; regenerative medicine; gene editing; mesenchymal stem cells; tissue engineering; cartilage repair; cardiac regeneration; epigenetic reprogramming
-
CRISPR-Cas genome editing has opened unprecedented possibilities for tissue engineering by enabling precise geneticprogramming of stem cells to enhance differentiation, survival, and functional integration within engineered constructs.This study applied three …
datacite
Elena Garcia, Pierre Jensen, Marco Popescu
2022
置信度 0.66
CRISPR-Cas9; Tissue engineering; CRISPRa; Base editing; iPSC-MSC; Osteogenesis; Chondrogenesis; Vascularisation
-
CRISPR-Cas genome editing has opened unprecedented possibilities for tissue engineering by enabling precise geneticprogramming of stem cells to enhance differentiation, survival, and functional integration within engineered constructs.This study applied three …
datacite
Elena Garcia, Pierre Jensen, Marco Popescu
2022
置信度 0.66
CRISPR-Cas9; Tissue engineering; CRISPRa; Base editing; iPSC-MSC; Osteogenesis; Chondrogenesis; Vascularisation
-
Gene editing technologies, particularly CRISPR-Cas9 and its variants, offer transformative therapeutic potential for neurological disorders including Alzheimer's, Parkinson's, Huntington's, ALS, and epileptic syndromes. This paper synthesizes current preclinic…
datacite
Gaeta, Dominic
2026
置信度 0.66
Gene Editingneurological disordersneuroethicsCRISPR-Cas Systems/geneticsneuroscience
-
Gene editing technologies, particularly CRISPR-Cas9 and its variants, offer transformative therapeutic potential for neurological disorders including Alzheimer's, Parkinson's, Huntington's, ALS, and epileptic syndromes. This paper synthesizes current preclinic…
datacite
Gaeta, Dominic
2026
置信度 0.66
Gene Editingneurological disordersneuroethicsCRISPR-Cas Systems/geneticsneuroscience
-
The rapidly developing field of biotechnology and genetic engineering uses living things, cells and biological systems to create products and technologies that enhance both human life and the environment. A crucial branch of biotechnology, genetic engineering …
datacite
K. Nalini, R. Yogakani, S. Muniasamy, T. Sivakumar
2026
置信度 0.66
Genetic engineering agriculture, food biotechnology, human development
-
The rapidly developing field of biotechnology and genetic engineering uses living things, cells and biological systems to create products and technologies that enhance both human life and the environment. A crucial branch of biotechnology, genetic engineering …
datacite
K. Nalini, R. Yogakani, S. Muniasamy, T. Sivakumar
2026
置信度 0.66
Genetic engineering agriculture, food biotechnology, human development
-
This technical article presents a comprehensive analysis of the current landscape in drug development, synthesizing insights across synthetic pathways, analytical characterization, and regulatory compliance. It begins by exploring sophisticated biological ther…
datacite
forensic chemistry
2026
置信度 0.66
Drug DevelopmentSynthetic PathwaysAnalytical CharacterizationArtificial IntelligenceRetrosynthesis
-
This technical article presents a comprehensive analysis of the current landscape in drug development, synthesizing insights across synthetic pathways, analytical characterization, and regulatory compliance. It begins by exploring sophisticated biological ther…
datacite
forensic chemistry
2026
置信度 0.66
Drug DevelopmentSynthetic PathwaysAnalytical CharacterizationArtificial IntelligenceRetrosynthesis
-
In order to recognize and eliminate the many different pathogens that the immune system can encounter, it generates an enormous repertoire of different unique T-cell receptors and B-cell immunoglobulins. The main contributor to this diversity is the process of…
datacite
Lisa Ott de Bruin
2018
置信度 0.66
RAG1 deficiencyCRISPR/Cas9autoimmunitymouse modelsimmunodeficiency
-
In order to recognize and eliminate the many different pathogens that the immune system can encounter, it generates an enormous repertoire of different unique T-cell receptors and B-cell immunoglobulins. The main contributor to this diversity is the process of…
datacite
Lisa Ott de Bruin
2018
置信度 0.66
RAG1 deficiencyCRISPR/Cas9autoimmunitymouse modelsimmunodeficiency
-
CRISPR-Cas9 gene editing has transitioned from a laboratory tool to a clinical therapeutic modality with remarkablespeed: the first CRISPR therapies for sickle cell disease and beta-thalassaemia (Casgevy; Vertex/CRISPR Therapeutics)received FDA and EMA approva…
datacite
Hugo Dubois, Sofia Hansen
2024
置信度 0.66
CRISPR-Cas9; oncology; CAR-T; gene editing; tumour suppressor; COQI; off-target editing; LNP delivery; checkpoint knockout; epigenome editing; KRAS; TP53; Switzerland; Esto
-
CRISPR-Cas9 gene editing has transitioned from a laboratory tool to a clinical therapeutic modality with remarkablespeed: the first CRISPR therapies for sickle cell disease and beta-thalassaemia (Casgevy; Vertex/CRISPR Therapeutics)received FDA and EMA approva…
datacite
Hugo Dubois, Sofia Hansen
2024
置信度 0.66
CRISPR-Cas9; oncology; CAR-T; gene editing; tumour suppressor; COQI; off-target editing; LNP delivery; checkpoint knockout; epigenome editing; KRAS; TP53; Switzerland; Esto
-
04 Genome Editing for Crop Improvement: Precision Targeting of Agronomic Traits and Disease Susceptibility Genes Jhilick Banerjee1*, Stuti Sharma2, Yogendra Singh3 1,2,3Department of Genetics and Plant Breeding, JNKVV, Jabalpur *Corresponding Author Email- jba…
datacite
Banerjee, Jhilick, Sharma, Stuti, Singh, Yogendra
2026
置信度 0.66
-
04 Genome Editing for Crop Improvement: Precision Targeting of Agronomic Traits and Disease Susceptibility Genes Jhilick Banerjee1*, Stuti Sharma2, Yogendra Singh3 1,2,3Department of Genetics and Plant Breeding, JNKVV, Jabalpur *Corresponding Author Email- jba…
datacite
Banerjee, Jhilick, Sharma, Stuti, Singh, Yogendra
2026
置信度 0.66
-
Cancer development is driven by diverse genetic aberrations, underscoring the importance of innovative approaches like gene therapy for effective treatment. The CRISPR/Cas9 gene-editing system has all the makings of a game-changing technique for future disease…
datacite
Deshmukh, Kalim
2026
置信度 0.66
CRISPR/Cas9biomarkerdrug delivery systemtheranosticscancer
-
Cancer development is driven by diverse genetic aberrations, underscoring the importance of innovative approaches like gene therapy for effective treatment. The CRISPR/Cas9 gene-editing system has all the makings of a game-changing technique for future disease…
datacite
Deshmukh, Kalim
2026
置信度 0.66
CRISPR/Cas9biomarkerdrug delivery systemtheranosticscancer
-
ABSTRACT Life sciences have undergone rapid transformation through molecular biology, genomics, biotechnology, and computational innovations. Current advances such as CRISPR gene editing, stem cell research, synthetic biology, and personalized medicine are res…
datacite
Kalyani, Mathangi
2026
置信度 0.66
-
ABSTRACT Life sciences have undergone rapid transformation through molecular biology, genomics, biotechnology, and computational innovations. Current advances such as CRISPR gene editing, stem cell research, synthetic biology, and personalized medicine are res…
datacite
Kalyani, Mathangi
2026
置信度 0.66
-
Gene editing by CRISPR/Cas9 offers great therapeutic opportunities but requires delivering large plasmid DNA (pDNA) into cells, a task for which transfection reagents are better suited than viral vectors. Here we performed a structure-activity relationship stu…
datacite
Zamolo, Susanna, Zakharova, Elena, Boursinhac, Lise, Hollfelder, Florian 等
2024
置信度 0.66
-
T helper (Th) cell lineages are linked to metabolism, but precise mechanisms in human Th1 cells remain unclear. We addressed this question by in vitro stimulation and CRISPR/Cas9-mediated gene editing. Metabolic profiling revealed enhanced glycolytic activity …
datacite
Abir, Ariful, Benz, Julia, Frey, Benjamin, Bruns, Heiko 等
2026
置信度 0.66
-
Cancer remains a leading cause of mortality worldwide, with drug resistance representing the primary barrier to sustained therapeutic success. Drug resistance may be classified as intrinsic (pre-existing) or acquired (developing under therapeutic pressure .and…
datacite
Manish Chaudhari*, Sujta Wagh, Mayuri Sonawane, Jayaprada Ghate
2026
置信度 0.66
Drug Resistance, Cancer Therapy, Intrinsic Resistance, Acquired Resistance, ABC Transporters, Tumor Microenvironment, Cancer Stem Cells, Cisplatin, PI3K/Akt, NF-κB, CRISPR, Immunotherapy, Precision Oncology, Artificial Intelligence
-
Cancer remains a leading cause of mortality worldwide, with drug resistance representing the primary barrier to sustained therapeutic success. Drug resistance may be classified as intrinsic (pre-existing) or acquired (developing under therapeutic pressure .and…
datacite
Manish Chaudhari*, Sujta Wagh, Mayuri Sonawane, Jayaprada Ghate
2026
置信度 0.66
Drug Resistance, Cancer Therapy, Intrinsic Resistance, Acquired Resistance, ABC Transporters, Tumor Microenvironment, Cancer Stem Cells, Cisplatin, PI3K/Akt, NF-κB, CRISPR, Immunotherapy, Precision Oncology, Artificial Intelligence
-
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder worldwide and is characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra, resulting in both motor and non-motor impairments. Although convent…
datacite
Anchal*, Rajesh Kumar, Ajeet Pal Singh, Amar Pal Singh, Gaurav Hastir
2026
置信度 0.66
Parkinson's disease; Single-cell RNA sequencing; Single-nucleus RNA sequencing; Multi-omics; Human substantia nigra; Dopaminergic neurons; Cell-type-specific mechanisms; Spatial transcriptomics; Biomarkers; Precision medicine; Artificial intelligence; Neurodegeneration
-
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder worldwide and is characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra, resulting in both motor and non-motor impairments. Although convent…
datacite
Anchal*, Rajesh Kumar, Ajeet Pal Singh, Amar Pal Singh, Gaurav Hastir
2026
置信度 0.66
Parkinson's disease; Single-cell RNA sequencing; Single-nucleus RNA sequencing; Multi-omics; Human substantia nigra; Dopaminergic neurons; Cell-type-specific mechanisms; Spatial transcriptomics; Biomarkers; Precision medicine; Artificial intelligence; Neurodegeneration
-
Precisely positioned nucleosomes and heterochromatin have been shown to impede CRISPR/Cas9 editing efficiency. Conversely, Cas9 can open previously inaccessible regions of DNA, and transcriptionally silent targets can usually be edited without difficulty. In o…
datacite
Kallimasioti Pazi, Eirini Margarita
2020
置信度 0.66
genome editingCRISPR/Cas9allele-specific chromatinheterochromatinNHEJ
-
Background: The advent of the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 technology marked the beginning of a new era in the field of molecular biology, allowing the efficient and precise creation of targeted mutations in the genom…
datacite
Zoppo, Marina, Okoniewski, Nicole, Pantelyushin, Stanislav, vom Berg, Johannes 等
2021
置信度 0.66
General BiochemistryGenetics and Molecular Biology570 Life sciences; biology590 Animals (Zoology)610 Medicine & health
-
این «ابر-لاگرانژیِ ۱۱۵۵-بعدی» (The 1155-D Super Lagrangian of HIP)، ساختارِ مادر برایِ تمامیِ فرآیندهایِ بیوشیمیایی است. در این ساحت، هیچ واکنشی «تصادفی» یا «آنتروپیک» نیست؛ بلکه هر واکنش، یک جابجاییِ تانسوری در منیفولدِ ۱۱۵۵ است. این لاگرانژی، تمامِ زیرشاخهه…
datacite
HAMZAH, SEYED RASOUL
2026
置信度 0.66
-
این «ابر-لاگرانژیِ ۱۱۵۵-بعدی» (The 1155-D Super Lagrangian of HIP)، ساختارِ مادر برایِ تمامیِ فرآیندهایِ بیوشیمیایی است. در این ساحت، هیچ واکنشی «تصادفی» یا «آنتروپیک» نیست؛ بلکه هر واکنش، یک جابجاییِ تانسوری در منیفولدِ ۱۱۵۵ است. این لاگرانژی، تمامِ زیرشاخهه…
datacite
HAMZAH, SEYED RASOUL
2026
置信度 0.66
-
The breast cancer risk conferred by germline protein truncating variants (PTVs) in known and putative breast cancer genes has been extensively investigated. However, the effect of FANCM PTVs on breast cancer risk remains unclear. Our previous clinical, genetic…
datacite
Billaud, Amandine, Figlioli, Gisella, Mooser, Clémence, Casamassima, Irene 等
2026
置信度 0.66
FANCMBreast Cancer RiskGenetic PredispositionMeta-analysisGene Editing
-
crossref
Wenfei Zhang
2024-11-29T05:12:20Z
置信度 0.70
-
crossref
B Graveley
2022-03-25T18:27:41Z
置信度 0.70
-
crossref
B Graveley
2023-03-28T23:24:23Z
置信度 0.70
-
crossref
B Graveley
2023-03-28T23:24:23Z
置信度 0.70