基因技术工具 · 全部实体（第 20 / 100 页）

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• CRISPR vs cholesterol: can gene editing prevent heart disease?
  crossref Heidi Ledford 2025-11-13T16:56:51Z 置信度 0.70
• ENCSR112YSN
  crossref B Graveley 2023-03-28T23:24:23Z 置信度 0.70
• ENCSR049HPU
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR283HNL
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR644JZK
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR037EPO
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR098LIW
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR249YGF
  crossref B Graveley 2023-03-28T23:24:23Z 置信度 0.70
• ENCSR037JLU
  crossref B Graveley 2023-03-28T23:24:23Z 置信度 0.70
• ENCSR952JNE
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR057UBZ
  crossref B Graveley 2023-03-28T23:24:23Z 置信度 0.70
• ENCSR542UKE
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR405TAI
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR933UFA
  crossref B Graveley 2023-03-28T23:24:23Z 置信度 0.70
• ENCSR027HBT
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR718VYC
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR561KET
  crossref B Graveley 2023-03-28T23:24:23Z 置信度 0.70
• CRISPR–Cas9 Gene Editing in T Cells Induces Site-Specific Chromosome Loss
  Abstract CRISPR–Cas9 gene editing in T cells can lead to partial or complete loss of the targeted chromosome.
  crossref 2023-10-13T12:53:43Z 置信度 0.70
• ENCSR420GEF
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR823WFJ
  crossref B Graveley 2023-03-28T23:24:23Z 置信度 0.70
• ENCSR242BBP
  crossref B Graveley 2023-03-28T23:24:23Z 置信度 0.70
• The CRISPR Era, the National Academies Report, and the Median Trait Barrier
  Abstract This chapter begins with the discovery of human gene editing, and how the immediate ethical response used the existing weakened barriers. The chapter then turns to a detailed analysis of how an influential report by the National Academies of Science, …
  crossref John H. Evans 2021-01-21T05:23:17Z 置信度 0.70
• ENCSR787FAG
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR713HFD
  crossref B Graveley 2023-03-28T23:24:23Z 置信度 0.70
• ENCSR957HNQ
  crossref B Graveley 2023-03-28T23:24:23Z 置信度 0.70
• ENCSR780BLP
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• EMERGING BIOTECHNOLOGICAL APPROACHES IN DIABETES MELLITUS: FROM RECOMBINANT INSULIN TO GENE AND STEM CELL THERAPIES
  Biotechnology is revolutionizing the treatment of diabetes by shifting from glucose-lowering medications to therapeutic strategies. The most recent in vivo treatments and devices for diabetes are reviewed in this review. These include gene therapy (viral or no…
  datacite Aditya Gupta, Suraj Yadav, Shreyansh Gupta, Ajeet Singh*, Dr. Manju Pandey, Dr. Neeraj Kumar Verma 2026 置信度 0.66
• Directed Evolution and Protein Engineering for the DNA Recognition of Miniature RNA-Guided DNA Nucleases
  The interplay between DNA and proteins extends beyond the transcription of protein coding genes. Proteins can return to bind DNA sequences, often with high specificity and precision. One example of DNA-binding proteins are RNA-guided DNA nucleases of clustered…
  datacite Wang, Jing Rui 2026 置信度 0.66 610 Medicine & health570 Life sciences; biology
• EpiLog: A Curated Genomic Safe Harbor Catalog and Post-Edit Silencing Registry
  EpiLog is a literature-derived catalog of genomic safe harbor loci and their post-editing expression/silencing outcomes, with per-record confidence tiers, stability/duration summaries, tissue context, and genome-build annotations, spanning human, mouse, dog, p…
  datacite de Paiva Menezes de Sequeira, Manuel Afonso 2026 置信度 0.66 genomic safe harborAAVS1ROSA26CRISPRtransgene silencing
• EpiLog: A Curated Genomic Safe Harbor Catalog and Post-Edit Silencing Registry
  EpiLog is a literature-derived catalog of genomic safe harbor loci and their post-editing expression/silencing outcomes, with per-record confidence tiers, stability/duration summaries, tissue context, and genome-build annotations, spanning human, mouse, dog, p…
  datacite de Paiva Menezes de Sequeira, Manuel Afonso 2026 置信度 0.66 genomic safe harborAAVS1ROSA26CRISPRtransgene silencing
• Application Of Crispr-Cas 9 In Treating Breast Cancer
  Cas9 in breast cancer research and therapeutic development, focusing on the targeted modification of oncogenes, tumor-suppressor genes, drug-resistance-associated genes, and molecular signaling pathways involved in tumor growth and metastasis. CRISPR-based scr…
  datacite Vasudevan Ranganathan*, Agarwal Roshini, Sahiya Lateef, Nande Deepika 2026 置信度 0.66 CRISPR-Cas9; Breast cancer; Genome editing; Precision medicine; Gene therapy; Triple-negative breast cancer (TNBC).
• Application Of Crispr-Cas 9 In Treating Breast Cancer
  Cas9 in breast cancer research and therapeutic development, focusing on the targeted modification of oncogenes, tumor-suppressor genes, drug-resistance-associated genes, and molecular signaling pathways involved in tumor growth and metastasis. CRISPR-based scr…
  datacite Vasudevan Ranganathan*, Agarwal Roshini, Sahiya Lateef, Nande Deepika 2026 置信度 0.66 CRISPR-Cas9; Breast cancer; Genome editing; Precision medicine; Gene therapy; Triple-negative breast cancer (TNBC).
• DEEP LEARNING-ENHANCED CRISPR/CAS9 GENE EDITING FOR CHRONIC MYELOGENOUS LEUKEMIA: TARGETED THERAPEUTICS AND OFF-TARGET PREDICTION
  datacite Zafar Iqbal Roy, Muhammad Usama Masood, Tahreem Saeed, Aleema Imran, Syed Zohaib Hassan, Muhammad Usman Javeed 2026 置信度 0.66
• DEEP LEARNING-ENHANCED CRISPR/CAS9 GENE EDITING FOR CHRONIC MYELOGENOUS LEUKEMIA: TARGETED THERAPEUTICS AND OFF-TARGET PREDICTION
  datacite Zafar Iqbal Roy, Muhammad Usama Masood, Tahreem Saeed, Aleema Imran, Syed Zohaib Hassan, Muhammad Usman Javeed 2026 置信度 0.66
• Insights into the Interaction of Heart Failure with Preserved Ejection Fraction and Sleep-Disordered Breathing
  Heart failure with preserved ejection fraction (HFpEF) is emerging as a widespread disease with global socioeconomic impact. Patients with HFpEF show a dramatically increased morbidity and mortality, and, unfortunately, specific treatment options are limited. …
  datacite Wester, Michael, Arzt, Michael, Sinha, Frederick, Maier, Lars S. 等 2023 置信度 0.66 PROTEIN-KINASE-II; POSITIVE AIRWAY PRESSURE; INTERMITTENT HYPOXIA; CARDIAC-HYPERTROPHY; INSULIN-RESISTANCE; APNEA; DYSFUNCTION; INFLAMMATION; PREVALENCE; ACTIVATION; heart failure; HFpEF; obstructive sleep apnea; central sleep apnea; pathomechanisms610 Medizin
• The dataset of article“<b>Preclinical </b><b>development of ZVS203e, a CRISPR/Cas9-based allele-specific gene editing therapy for </b><b><i>RHO-R135W</i></b><b> </b><b>mutation</b><b>–</b><b>induced</b><b> RHO-adRP</b>”
  We developed an adeno-associated virus-based CRISPR/Cas9 gene editing therapy, ZVS203e and evaluated its efficacy and mechanism of action in 293A cells, human-derived induced pluripotent stem cells, and humanized retinitis pigmentosa model mice (Rhowt/R135W). …
  datacite Jing Qiao 2026 置信度 0.66 Genetics not elsewhere classified
• The dataset of article“<b>Preclinical </b><b>development of ZVS203e, a CRISPR/Cas9-based allele-specific gene editing therapy for </b><b><i>RHO-R135W</i></b><b> </b><b>mutation</b><b>–</b><b>induced</b><b> RHO-adRP</b>”
  We developed an adeno-associated virus-based CRISPR/Cas9 gene editing therapy, ZVS203e and evaluated its efficacy and mechanism of action in 293A cells, human-derived induced pluripotent stem cells, and humanized retinitis pigmentosa model mice (Rhowt/R135W). …
  datacite Jing Qiao 2026 置信度 0.66 Genetics not elsewhere classified
• The dataset of article“<b>Preclinical </b><b>development of ZVS203e, a CRISPR/Cas9-based allele-specific gene editing therapy for </b><b><i>RHO-R135W</i></b><b> </b><b>mutation</b><b>–</b><b>induced</b><b> RHO-adRP</b>”
  We developed an adeno-associated virus-based CRISPR/Cas9 gene editing therapy, ZVS203e and evaluated its efficacy and mechanism of action in 293A cells, human-derived induced pluripotent stem cells, and humanized retinitis pigmentosa model mice (Rhowt/R135W). …
  datacite Jing Qiao 2026 置信度 0.66 Genetics not elsewhere classified
• Genetic Determinants of the Development and Evolution of Drosophila Pigmentation
  Understanding the relationships between DNA sequence and organismal phenotypes has been a central goal across a wide variety of biological subdisciplines throughout the history of genetics research. Studies of the developmental genetic mechanisms underlying ph…
  datacite Lamb, Abigail 2021 置信度 0.66 EvolutionmicroRNADevelopmentEvo-DevoGene expression
• The roadmap for the development of the Human Variome - Development of functional multi-omics analyses for the understanding of human biology
  The human variome encompasses the full spectrum of genetic variation underlying human biology, health, and disease. Recent advances in next-generation sequencing and multi-omics, including genomics, epigenomics, transcriptomics, proteomics, and metabolomics, h…
  datacite Tumiene, Birute, Adams, David R., Allaway, Robert, Barrero, Maria J. 等 2026 置信度 0.66 Human GenomeVariomeFunctional analysisVariant of uncertain significanceGenetic diagnosis
• The roadmap for the development of the Human Variome - Development of functional multi-omics analyses for the understanding of human biology
  The human variome encompasses the full spectrum of genetic variation underlying human biology, health, and disease. Recent advances in next-generation sequencing and multi-omics, including genomics, epigenomics, transcriptomics, proteomics, and metabolomics, h…
  datacite Tumiene, Birute, Adams, David R., Allaway, Robert, Barrero, Maria J. 等 2026 置信度 0.66 Human GenomeVariomeFunctional analysisVariant of uncertain significanceGenetic diagnosis
• EpiLog: A Curated Genomic Safe Harbor Catalog and Post-Edit Silencing Registry
  EpiLog is a literature-derived catalog of genomic safe harbor loci and their post-editing expression/silencing outcomes, with per-record confidence tiers, stability/duration summaries, tissue context, and genome-build annotations, spanning human, mouse, dog, p…
  datacite de Paiva Menezes de Sequeira, Manuel Afonso 2026 置信度 0.66 genomic safe harborAAVS1ROSA26CRISPRtransgene silencing
• CRISPR-Cas Technology in Plant Breeding: Innovations, Applications and Future Perspectives
  There is a growing need for efficient plant-breeding approaches due to the ongoing need for higher productivity, nutritional quality, and resistance to pests and diseases, along with climate resilience. While conventional breeding has had significant contribut…
  datacite Vishal Pareek1, Santhosh B. L.2*, Dr. Biju Sidharthan3 and Shivendra Singh4 2026 置信度 0.66
• CRISPR-Cas Technology in Plant Breeding: Innovations, Applications and Future Perspectives
  There is a growing need for efficient plant-breeding approaches due to the ongoing need for higher productivity, nutritional quality, and resistance to pests and diseases, along with climate resilience. While conventional breeding has had significant contribut…
  datacite Vishal Pareek1, Santhosh B. L.2*, Dr. Biju Sidharthan3 and Shivendra Singh4 2026 置信度 0.66
• Supplementary materials for chapter 2: PMR4 is a susceptibility gene for soft rot disease in potato
  This dataset contains the supplementary materials associated with Chapter 2 of Pichaya T. Cheewapoonphon's PhD thesis, including the data and results from RNA-sequencing analysis (RNA quantity, Differential Gene Expression (DEGs), Gene Ontology (GO) and Kyoto …
  datacite Cheewapoonphon, Pichaya, Zhe Yan, Yue Wang, Icía Cambeiro Tajes 等 2026 置信度 0.66 Plant BiologyGeneticsAgricultural BiotechnologyTechnologyBiological Sciences
• Supplementary materials for chapter 2: PMR4 is a susceptibility gene for soft rot disease in potato
  This dataset contains the supplementary materials associated with Chapter 2 of Pichaya T. Cheewapoonphon's PhD thesis, including the data and results from RNA-sequencing analysis (RNA quantity, Differential Gene Expression (DEGs), Gene Ontology (GO) and Kyoto …
  datacite Cheewapoonphon, Pichaya, Zhe Yan, Yue Wang, Icía Cambeiro Tajes 等 2026 置信度 0.66 Plant BiologyGeneticsAgricultural BiotechnologyTechnologyBiological Sciences
• Advances in Plant Sciences: Molecular Biology, Tissue Culture, Genomics and CRISPR Technologies
  New developments in plant sciences have transformed biotechnology, sustainable crop production, and modern agriculture. The fields of molecular biology, tissue culture, genomics, proteomics, and CRISPR-based gene editing have emerged as potent instruments for …
  datacite Harshika Kamlesh Pardeshi 2026 置信度 0.66 Molecular Biology, Plant Tissue Culture, Genomics, Proteomics, CRISPR, Gene Editing.
• ENCSR798UAK
  crossref B Graveley 2023-03-28T23:24:23Z 置信度 0.70
• ENCSR418VOT
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR636LSV
  crossref B Graveley 2023-03-28T23:24:23Z 置信度 0.70
• ENCSR620VTT
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR407XDO
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR919NYR
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR793HOO
  crossref B Graveley 2023-03-28T23:24:23Z 置信度 0.70
• ENCSR648SPD
  crossref B Graveley 2023-03-28T23:24:23Z 置信度 0.70
• ENCSR005MID
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR816GWS
  crossref B Graveley 2023-03-28T23:24:23Z 置信度 0.70
• ENCSR424ALD
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR134POC
  crossref B Graveley 2023-03-28T23:24:23Z 置信度 0.70
• ENCSR590UTB
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR586DOD
  crossref B Graveley 2023-03-28T23:24:23Z 置信度 0.70
• Gene editing in hemophilia: a “CRISPR” choice?
  crossref Steven W. Pipe, Sundar R. Selvaraj 2019-06-27T17:29:12Z 置信度 0.70
• ENCSR439DQM
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR019QSE
  crossref B Graveley 2023-03-28T23:24:23Z 置信度 0.70
• ENCSR361EKV
  crossref B Graveley 2023-03-28T23:24:23Z 置信度 0.70
• ENCSR073ZUO
  crossref B Graveley 2023-03-28T23:24:23Z 置信度 0.70
• ENCSR004UEZ
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR890SYA
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR930RXK
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• CRISPR, a New Technique for Gene Editing***
  crossref Steve Caplan 2021-10-10T22:43:55Z 置信度 0.70
• ENCSR576LAK
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR298YMO
  crossref B Graveley 2023-03-28T23:24:23Z 置信度 0.70
• ENCSR480STK
  crossref B Graveley 2023-03-28T23:24:23Z 置信度 0.70
• ENCSR768GEJ
  crossref B Graveley 2023-03-28T23:24:23Z 置信度 0.70
• Application and Prospect of CRISPR-Cas9 Gene Editing Technology in Agricultural Breeding
  Since its inception in 2012, the gene editing technology CRISPR-Cas9 has rapidly become a revolutionary tool in the field of gene editing due to its high efficiency, specificity, and ease of operation. In the field of agricultural breeding, the application of …
  crossref Huadong Yang 2025-03-24T15:17:11Z 置信度 0.70
• ENCSR441GUL
  crossref B Graveley 2023-03-28T23:24:23Z 置信度 0.70
• ENCSR098JWL
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR706XVM
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR463EFP
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR693JZN
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR747UUF
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR835EFB
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR610FMR
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR370LQM
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR666QHG
  crossref B Graveley 2023-03-28T23:24:23Z 置信度 0.70
• ENCSR156XPB
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR955LXJ
  crossref B Graveley 2023-03-28T23:24:23Z 置信度 0.70
• ENCSR361QAM
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR737UDV
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR513MXV
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR053TLP
  crossref B Graveley 2023-03-28T23:24:23Z 置信度 0.70
• ENCSR115EVX
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR486LUC
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR613AQN
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR230NEZ
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR548YWH
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR281QCJ
  crossref B Graveley 2023-03-28T23:24:23Z 置信度 0.70
• ENCSR545ARH
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR327GCA
  crossref B Graveley 2022-03-25T18:27:41Z 置信度 0.70
• ENCSR148CJC
  crossref B Graveley 2023-03-28T23:24:23Z 置信度 0.70