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• Issue 43 | Faculty of Regenerative Genomic Medicine - Genes, Epigenetics, Regulation, and Repair
  Archival deposit of the International Virtual University of Regenerative Health (IVURH) Newsletter, Foundational Series, Issue 43, originally issued on 8 February 2012. This issue introduces the proposed Faculty of Regenerative Genomic Medicine within IVURH an…
  datacite Yusuf, MD, M A 2012 置信度 0.66 MedicineRegenerative MedicineGenomic MedicineGenomic Medicine/ethicsGenomic Medicine/instrumentation
• CRISPR Cas9 Gene Editing in Monogenic Rare Diseases
  datacite Amer, Mustafa 2026 置信度 0.66
• CRISPR Cas9 Gene Editing in Monogenic Rare Diseases
  datacite Amer, Mustafa 2026 置信度 0.66
• Decoding the Unknown: A Research-Focused Guide to Interpreting Genetic Variants of Uncertain Significance
  This comprehensive article addresses the critical challenge of Variants of Uncertain Significance (VUS) in clinical genomics and precision medicine. A VUS is a genetic alteration lacking sufficient evidence to be classified as definitively pathogenic or benign…
  datacite genetics science 2026 置信度 0.66 Variants of Uncertain SignificanceVUSclinical genomicsACMG-AMP frameworkMultiplexed Assays of Variant Effect
• Decoding the Unknown: A Research-Focused Guide to Interpreting Genetic Variants of Uncertain Significance
  This comprehensive article addresses the critical challenge of Variants of Uncertain Significance (VUS) in clinical genomics and precision medicine. A VUS is a genetic alteration lacking sufficient evidence to be classified as definitively pathogenic or benign…
  datacite genetics science 2026 置信度 0.66 Variants of Uncertain SignificanceVUSclinical genomicsACMG-AMP frameworkMultiplexed Assays of Variant Effect
• Mechanisms of Action and Overcoming Obstacles in Solid Tumours with Chimeric Antigen Receptor (CAR) T-Cell Therapy
  A revolutionary method in oncological immunotherapy is chimeric antigen receptor T-cell (CAR-T) therapy, which involves isolating a patient's own T cells, genetically reprogramming them ex vivo to express synthetic antigen-binding receptors, and then reinfusin…
  datacite Ankita Raman Mhaske, Gayatri Suryabhan Thete, Aman Upaganlawar, Chandrashekhar Upasani 2026 置信度 0.66
• Mechanisms of Action and Overcoming Obstacles in Solid Tumours with Chimeric Antigen Receptor (CAR) T-Cell Therapy
  A revolutionary method in oncological immunotherapy is chimeric antigen receptor T-cell (CAR-T) therapy, which involves isolating a patient's own T cells, genetically reprogramming them ex vivo to express synthetic antigen-binding receptors, and then reinfusin…
  datacite Ankita Raman Mhaske, Gayatri Suryabhan Thete, Aman Upaganlawar, Chandrashekhar Upasani 2026 置信度 0.66
• Mechanisms of Action and Overcoming Obstacles in Solid Tumours with Chimeric Antigen Receptor (CAR) T-Cell Therapy
  A revolutionary method in oncological immunotherapy is chimeric antigen receptor T-cell (CAR-T) therapy, which involves isolating a patient's own T cells, genetically reprogramming them ex vivo to express synthetic antigen-binding receptors, and then reinfusin…
  datacite Ankita Raman Mhaske, Gayatri Suryabhan Thete, Aman Upaganlawar, Chandrashekhar Upasani 2026 置信度 0.66
• Whose Evolution Is Faster? 5 Powerful Technologies Racing Ahead of Their Human Builders
  This article examines whether human-built technologies are evolving faster than human beings themselves, comparing the timescale of human biological evolution (approximately 2 million years per major genetic adaptation) against the documented growth rates of f…
  datacite Rout, Narayan 2026 置信度 0.66 whose evolution is faster technology humantechnology evolving faster than humansAI compute growth rate 2025CRISPR gene editing timeline 2012 2025Google Willow quantum chip 2025
• Whose Evolution Is Faster? 5 Powerful Technologies Racing Ahead of Their Human Builders
  This article examines whether human-built technologies are evolving faster than human beings themselves, comparing the timescale of human biological evolution (approximately 2 million years per major genetic adaptation) against the documented growth rates of f…
  datacite Rout, Narayan 2026 置信度 0.66 whose evolution is faster technology humantechnology evolving faster than humansAI compute growth rate 2025CRISPR gene editing timeline 2012 2025Google Willow quantum chip 2025
• DIABETOLOGY IN MODERN PHARMACY: AN UPDATED AND CONCISE REVIEW
  Diabetes Mellitus (DM) has proliferated into one of the most formidable global public health crises of the 21st century, currently afflicting over 537 million adults worldwide with projections indicating a continuous surge. This comprehensive review article sy…
  datacite 1*Sikander Ali Sheikh, 2Kashi Ram, 3Himanshu Soni, 4Lakhsya Panchariya 2026 置信度 0.66
• DIABETOLOGY IN MODERN PHARMACY: AN UPDATED AND CONCISE REVIEW
  Diabetes Mellitus (DM) has proliferated into one of the most formidable global public health crises of the 21st century, currently afflicting over 537 million adults worldwide with projections indicating a continuous surge. This comprehensive review article sy…
  datacite 1*Sikander Ali Sheikh, 2Kashi Ram, 3Himanshu Soni, 4Lakhsya Panchariya 2026 置信度 0.66
• RCE-PAT-001 — Irreversibility and Recoverability Analysis in Patent Systems — Evidentiary Record and Admissibility Assessment
  This publication constitutes a formal evidentiary record analysing irreversibility and admissibility conditions in patent systems under the Recoverability-Constrained Systems framework. The record evaluates real-world patents across biotechnology, artificial i…
  datacite Sanchez, Noelia 2026 置信度 0.66 recoverability irreversibility patent systems admissibility biotechnology CRISPR gene drive artificial intelligence autonomous systems risk analysis system safety regulatory gaps innovation governance technology ethics
• RCE-PAT-001 — Irreversibility and Recoverability Analysis in Patent Systems — Evidentiary Record and Admissibility Assessment
  This publication constitutes a formal evidentiary record analysing irreversibility and admissibility conditions in patent systems under the Recoverability-Constrained Systems framework. The record evaluates real-world patents across biotechnology, artificial i…
  datacite Sanchez, Noelia 2026 置信度 0.66 recoverability irreversibility patent systems admissibility biotechnology CRISPR gene drive artificial intelligence autonomous systems risk analysis system safety regulatory gaps innovation governance technology ethics
• Engineered Exosomes for Neurological Disorders: From Biomarkers to Brain-Targeted Drug Delivery and Clinical Translation
  Neurological disorders, including Alzheimer’s disease, Parkinson’s disease, glioblastoma, ischemic stroke, multiple sclerosis, amyotrophic lateral sclerosis, Huntington’s disease, traumatic brain injury, and spinal cord injury, remain major causes of mortality…
  datacite Yash Kothikar*, Tanveer Patel 2026 置信度 0.66 Engineered exosomes; Neurological disorders; Blood–brain barrier; Brain-targeted drug delivery; Extracellular vesicles; Nanomedicine
• Engineered Exosomes for Neurological Disorders: From Biomarkers to Brain-Targeted Drug Delivery and Clinical Translation
  Neurological disorders, including Alzheimer’s disease, Parkinson’s disease, glioblastoma, ischemic stroke, multiple sclerosis, amyotrophic lateral sclerosis, Huntington’s disease, traumatic brain injury, and spinal cord injury, remain major causes of mortality…
  datacite Yash Kothikar*, Tanveer Patel 2026 置信度 0.66 Engineered exosomes; Neurological disorders; Blood–brain barrier; Brain-targeted drug delivery; Extracellular vesicles; Nanomedicine
• Advanced Metabolic Engineering Strategies for Developing Microbial Cell Factories
  This extensive technical review provides a detailed roadmap for the development and optimization of microbial cell factories through advanced systems metabolic engineering. Microbial cell factories are engineered microorganisms designed to sustainably convert …
  datacite metabolic engineering 2026 置信度 0.66 Microbial Cell FactoriesMetabolic EngineeringSynthetic BiologyCRISPR-Cas9Genome-Scale Metabolic Models
• Advanced Metabolic Engineering Strategies for Developing Microbial Cell Factories
  This extensive technical review provides a detailed roadmap for the development and optimization of microbial cell factories through advanced systems metabolic engineering. Microbial cell factories are engineered microorganisms designed to sustainably convert …
  datacite metabolic engineering 2026 置信度 0.66 Microbial Cell FactoriesMetabolic EngineeringSynthetic BiologyCRISPR-Cas9Genome-Scale Metabolic Models
• Seven Diseases That Could Be Treated by CRISPR-Cas9: A Revolutionary Gene-Editing Technology
  A concise review of CRISPR-Cas9 gene-editing technology, highlighting its principles, clinical applications, therapeutic potential, and emerging role in precision genomic medicine. Author website: https://drhakimemedivault.com Google Scholar Profile: https://s…
  datacite Saboowala, Hakim. 2026 置信度 0.66 CRISPR-Cas9; Gene Editing; Genome Editing; Precision Medicine; Genetic Diseases; Gene Therapy; Genomic Medicine; Biotechnology
• Seven Diseases That Could Be Treated by CRISPR-Cas9: A Revolutionary Gene-Editing Technology
  A concise review of CRISPR-Cas9 gene-editing technology, highlighting its principles, clinical applications, therapeutic potential, and emerging role in precision genomic medicine. Author website: https://drhakimemedivault.com Google Scholar Profile: https://s…
  datacite Saboowala, Hakim. 2026 置信度 0.66 CRISPR-Cas9; Gene Editing; Genome Editing; Precision Medicine; Genetic Diseases; Gene Therapy; Genomic Medicine; Biotechnology
• CRISPR/CAS Technology: A Promising Tool For The Treatment Of Central Nervous System Disorders
  The increasing number of people suffering from neurological disorders is concerning and hence, there is an immediate need to build an effective therapy to lessen this burden. For the past decade, Clustered Regularly Interspaced Short Palindromic Repeats (CRISP…
  datacite Madhurima Tiwari1, Shifa Ahmad2, Poonam Tripathi3, Deepika Delsa Dean* 2026 置信度 0.66 CRISPR/Cas; Neurological disorders; Gene therapy; Central nervous system; Delivery methods of CRISPR
• CRISPR/CAS Technology: A Promising Tool For The Treatment Of Central Nervous System Disorders
  The increasing number of people suffering from neurological disorders is concerning and hence, there is an immediate need to build an effective therapy to lessen this burden. For the past decade, Clustered Regularly Interspaced Short Palindromic Repeats (CRISP…
  datacite Madhurima Tiwari1, Shifa Ahmad2, Poonam Tripathi3, Deepika Delsa Dean* 2026 置信度 0.66 CRISPR/Cas; Neurological disorders; Gene therapy; Central nervous system; Delivery methods of CRISPR
• Map the direct mechanical and axonal transport pathways connecting intranasal administration or trigeminal nerve delivery to the clearance of TDP-43 aggregates in sporadic ALS, and the delivery of CRISPR-Cas/ASO gene therapies targeting C9orf72 hexanucleotide repeat expansions in the cerebellum and brainstem. - PathMap Experiment #000038
  Interactive Data Viewer: Read, View, and Print from Day 1 Use our fully interactive viewer to view, read, and print this research data right from Day 1: https://pathmap.org/viewer.php?id=38 Artificial General Intelligence LLC Claim Evaluated: Map the direct me…
  datacite Dungan, Joshua 2026 置信度 0.66 Intranasal Route_gates_from_intranasal_routeBlood-Brain Barrier_gates_to_blood-brain_barrierC9orf72 Protein
• Map the direct mechanical and axonal transport pathways connecting intranasal administration or trigeminal nerve delivery to the clearance of TDP-43 aggregates in sporadic ALS, and the delivery of CRISPR-Cas/ASO gene therapies targeting C9orf72 hexanucleotide repeat expansions in the cerebellum and brainstem. - PathMap Experiment #000038
  Interactive Data Viewer: Read, View, and Print from Day 1 Use our fully interactive viewer to view, read, and print this research data right from Day 1: https://pathmap.org/viewer.php?id=38 Artificial General Intelligence LLC Claim Evaluated: Map the direct me…
  datacite Dungan, Joshua 2026 置信度 0.66 Intranasal Route_gates_from_intranasal_routeBlood-Brain Barrier_gates_to_blood-brain_barrierC9orf72 Protein
• Advances in the Syntheses of Fusarium-Derived Natural Products: Progress Toward Immunomodulide and the Total Synthesis of Fusahexin
  Fungal natural products represent a chemically diverse and pharmacologically rich source of bioactive scaffolds, yet the majority remain incompletely characterized at the level of structure, biosynthesis, and biological function. Across the 12-membered cyclic …
  datacite Natola, Claudia 2026 置信度 0.66 Total synthesisFusahexinImmunomodulideTridepsipeptidesMacrolactamization
• Microbiome Modifications for Climate Resilience
  Climate change (CC) is basically destabilizing global agriculture system driving unprecedented drought, heat stress, salinity intrusion, and erratic precipitation patterns that threaten food security for the world population. deliberate manipulation of plant-a…
  datacite Rishitha, Shaik, Sairam, Masina, Ray, Sumit, Sagar, Lalichetti 等 2026 置信度 0.66
• Microbiome Modifications for Climate Resilience
  Climate change (CC) is basically destabilizing global agriculture system driving unprecedented drought, heat stress, salinity intrusion, and erratic precipitation patterns that threaten food security for the world population. deliberate manipulation of plant-a…
  datacite Rishitha, Shaik, Sairam, Masina, Ray, Sumit, Sagar, Lalichetti 等 2026 置信度 0.66
• Mol.Col: A browser-based offline lipid nanoparticle formulation calculator
  Mol.Col is a browser-based offline calculator for lipid nanoparticle (LNP) formulation, developed as part of a PhD thesis at the Faculty of Biology, Albert-Ludwigs-Universität Freiburg, conducted at the Institute for Transfusion Medicine and Gene Therapy, Cent…
  datacite maryam, Taghdiri 2026 置信度 0.66 lipid nanoparticleLNP formulationmRNA deliverygene editingCRISPR
• Evaluating resistance to Tilapia Lake Virus in tilapia using CRISPR/Cas editing
  Tilapia lake virus (TiLV) is a recently discovered RNA virus that causes severe disease in tilapia, a major aquaculture species worldwide. TiLV outbreaks have been reported across Asia, Africa, and Latin America, often resulting in high mortality rates and eco…
  datacite Wang, Jiaqi 2026 置信度 0.66 tilapiaTilapia Lake VirusTiLVCRISPR/Cas9Mozambique tilapia brain cell line
• Neural development in Fragile X Syndrome using human iPSC models
  Fragile X Syndrome (FXS) is a neurodevelopmental disorder characterized by a variety of symptoms from intellectual disability to anxiety, sensory hypersensitivity, epilepsy, and autistic behavior. It is caused by a loss of expression of the FMRP protein, resul…
  datacite Ritakari, Tuula Elina 2022 置信度 0.66 Fragile X SyndromeFXSneural stem cells
• Hybrid Biological Technology for Cardiac Hypertrophy Reversal and Essential Hypertension Elimination: A Multidisciplinary Conceptual–Normative Framework with Multiscale Mathematical Modelling, Bayesian Inference, and Reproducible Computational Validation
  Background. Cardiac hypertrophy and essential hypertension are convergent pathophysiological endpoints of sustained haemodynamic overload, mechanotransduction dysregulation, and neurohormonal activation. Despite pharmacological advances—including cardiac myosi…
  datacite Shibah, Sami Rashid Mohammed 2026 置信度 0.66
• Hybrid Biological Technology for Cardiac Hypertrophy Reversal and Essential Hypertension Elimination: A Multidisciplinary Conceptual–Normative Framework with Multiscale Mathematical Modelling, Bayesian Inference, and Reproducible Computational Validation
  Background. Cardiac hypertrophy and essential hypertension are convergent pathophysiological endpoints of sustained haemodynamic overload, mechanotransduction dysregulation, and neurohormonal activation. Despite pharmacological advances—including cardiac myosi…
  datacite Shibah, Sami Rashid Mohammed 2026 置信度 0.66
• Genetically Modified Foods: Legal and Scientific Overview of Manipulation Techniques Application and Public Policy Challenges
  Genetically Modified foods are a unique point of convergence between biotechnology, law, and policy, providing answers to food security issues globally with the challenges of climate change. The article is a scientific summary of the manipulation practices, bo…
  datacite Nikitha Kotteswaran 2025 置信度 0.66
• Genetically Modified Foods: Legal and Scientific Overview of Manipulation Techniques Application and Public Policy Challenges
  Genetically Modified foods are a unique point of convergence between biotechnology, law, and policy, providing answers to food security issues globally with the challenges of climate change. The article is a scientific summary of the manipulation practices, bo…
  datacite Nikitha Kotteswaran 2025 置信度 0.66
• Curing Type 1 Diabetes Without Lifelong Immunosuppression
  Think of blood sugar as the water level in a tank, kept steady by an automatic valve. Intype 1 diabetes the body’s own immune system destroys the valve, so the level swingsdangerously and the person must dose insulin by hand for life. The real fix is to instal…
  datacite Ramirez, Marc Anthony 2026 置信度 0.66 Type 1 diabetesislet cell transplantationstem cell–derived isletshypoimmune gene editingimmunosuppression-free cell therapy
• Curing Type 1 Diabetes Without Lifelong Immunosuppression
  Think of blood sugar as the water level in a tank, kept steady by an automatic valve. Intype 1 diabetes the body’s own immune system destroys the valve, so the level swingsdangerously and the person must dose insulin by hand for life. The real fix is to instal…
  datacite Ramirez, Marc Anthony 2026 置信度 0.66 Type 1 diabetesislet cell transplantationstem cell–derived isletshypoimmune gene editingimmunosuppression-free cell therapy
• NANOPARTICULATE DRUG DELIVERY SYSTEMS IN CYSTIC FIBROSIS THERAPY: A COMPREHENSIVE REVIEW OF FORMULATION STRATEGIES, MUCUS PENETRATION MECHANISMS, TARGETED PULMONARY DELIVERY, AND TRANSLATIONAL CHALLENGES
  Nanoparticulate drug delivery systems have emerged as a transformative approach in the management of Cystic Fibrosis, a complex genetic disorder characterized by impaired mucociliary clearance, thickened airway mucus, and chronic pulmonary infections. Conventi…
  datacite Pooja Pandurang Durke*, Prof. Dr. R. S. Wanare 2026 置信度 0.66
• NANOPARTICULATE DRUG DELIVERY SYSTEMS IN CYSTIC FIBROSIS THERAPY: A COMPREHENSIVE REVIEW OF FORMULATION STRATEGIES, MUCUS PENETRATION MECHANISMS, TARGETED PULMONARY DELIVERY, AND TRANSLATIONAL CHALLENGES
  Nanoparticulate drug delivery systems have emerged as a transformative approach in the management of Cystic Fibrosis, a complex genetic disorder characterized by impaired mucociliary clearance, thickened airway mucus, and chronic pulmonary infections. Conventi…
  datacite Pooja Pandurang Durke*, Prof. Dr. R. S. Wanare 2026 置信度 0.66
• Research data supporting: "Plasticity-first evolution via CYP405 loss shaped chemical defences in butterflies"
  The dataset contains raw chemical data of Heliconius erato demophoon larvae from an CRISPR experiment (gene-editing). H. erato larvae derived from eggs injected with either just Cas9 (control) or Cas9 + single guides RNA targeting the gene CYP405A involved in …
  datacite Pinheiro De Castro, Erika, Cicconardi, Francesco, Warren, Ian, Rueda-M, Nicol 等 2026 置信度 0.66 ButterfliesChemical defenseHeliconiusPlasticity
• Inactivation of Cerebral Cavernous Malformation Genes Results in Accumulation of von Willebrand Factor and Redistribution of Weibel-Palade Bodies in Endothelial Cells
  Cerebral cavernous malformations are slow-flow thrombi-containing vessels induced by two-step inactivation of the CCM1, CCM2 or CCM3 gene within endothelial cells. They predispose to intracerebral bleedings and focal neurological deficits. Our understanding of…
  datacite Much, Christiane D., Sendtner, Barbara S., Schwefel, Konrad, Freund, Eric 等 2021 置信度 0.66 570cerebral cavernous malformationCCM1blood outgrowth endothelial cellsCRISPR/Cas9
• Endothelial Differentiation of CCM1 Knockout iPSCs Triggers the Establishment of a Specific Gene Expression Signature
  Cerebral cavernous malformation (CCM) is a neurovascular disease that can lead to seizures and stroke-like symptoms. The familial form is caused by a heterozygous germline mutation in either the CCM1, CCM2, or CCM3 gene. While the importance of a second-hit me…
  datacite Pilz, Robin A., Skowronek, Dariush, Mellinger, Lara, Bekeschus, Sander 等 2023 置信度 0.66 570540CCM1/KRIT1cerebral cavernous malformationCRISPR/Cas9 genome editing
• CRISPR-Based Gene Editing in Rare Genetic Disorders
  CRISPR-Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats associated protein 9) gene editing -- theprogrammable RNA-guided endonuclease system that generates sequence-specific DNA double-strand breaks followedby cellular repair through homology-di…
  datacite Marco Klein 2022 置信度 0.66 CRISPR-Cas9; gene editing; sickle cell disease; beta-thalassaemia; base editing; prime editing; off-target; rare genetic disorders
• CRISPR-Based Gene Editing in Rare Genetic Disorders
  CRISPR-Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats associated protein 9) gene editing -- theprogrammable RNA-guided endonuclease system that generates sequence-specific DNA double-strand breaks followedby cellular repair through homology-di…
  datacite Marco Klein 2022 置信度 0.66 CRISPR-Cas9; gene editing; sickle cell disease; beta-thalassaemia; base editing; prime editing; off-target; rare genetic disorders
• EMERGING BIOTECHNOLOGICAL APPROACHES IN DIABETES MELLITUS: FROM RECOMBINANT INSULIN TO GENE AND STEM CELL THERAPIES
  Biotechnology is revolutionizing the treatment of diabetes by shifting from glucose-lowering medications to therapeutic strategies. The most recent in vivo treatments and devices for diabetes are reviewed in this review. These include gene therapy (viral or no…
  datacite Aditya Gupta, Suraj Yadav, Shreyansh Gupta, Ajeet Singh*, Dr. Manju Pandey, Dr. Neeraj Kumar Verma 2026 置信度 0.66
• Conditional Gene Knockout in Human Cells with Inducible CRISPR/Cas9
  crossref Kirsten E. Snijders, James D. Cooper, Ludovic Vallier, Alessandro Bertero 2019-03-25T09:03:05Z 置信度 0.70
• From CRISPR to DNA writing: expanding the gene editing toolbox
  “It is amazing to witness the speed by which discovery can now be translated into practice.”Abi Pinchbeck (Editor, BioInsights) speaks to Laura Sepp-Lorenzino (Scientific Advisor and former CSO, Intellia Therapeutics) about the evolution and future of gene edi…
  crossref Laura Sepp-Lorenzino 2025-12-11T16:51:16Z 置信度 0.70
• Extraterritorial Patent Infringement: Gene Editing with CRISPR-Cas Perspective
  The advent of CRISPR, with all its extraordinary potential, has exposed some seams and uncertainties in how U.S. patent law operates extraterritorially. The CRISPR-Cas system can be used to edit the human genome to correct diseases by way of a gRNA that guides…
  crossref Laura Kohli 2024-10-30T23:03:41Z 置信度 0.70
• Decision letter for "CRISPR/Cas9 editing in conditionally immortalized HoxB8 cells for studying gene regulation in mouse dendritic cells"
  crossref 2021-11-29T09:18:56Z 置信度 0.70
• The Ethical Implications of CRISPR/Cas9 Gene Editing
  crossref Rebecca Shapiro, Rebecca Stevens-Green 2020-01-16T15:36:42Z 置信度 0.70
• Decision letter for "CRISPR/Cas9 editing in conditionally immortalized HoxB8 cells for studying gene regulation in mouse dendritic cells"
  crossref 2021-11-29T09:18:56Z 置信度 0.70
• CRISPR–Cas Gene Editing for Neurological Disease
  crossref Bryan P. Simpson, Beverly L. Davidson 2019-06-28T13:20:11Z 置信度 0.70
• CRISPR-Based Gene Editing Techniques in Pediatric Neurologic Disorders
  crossref Stephen M. Chrzanowski, Ranjan Batra 2022-09-24T09:17:17Z 置信度 0.70
• Gene Editing Improves the Agronomic Important Traits of Wheat – CRISPR-Cas9 and Cas12/Cpf1
  A hexaploid Wheat (Triticum aestivum L.) is the 3rd most important staple food crop with 15% caloric intake next to maize and rice in the world. The global attention for wheat improvement are still encouraging. However, the population growth and demand for foo…
  crossref Habtamu Kefale, Sewnet Getahun 2022-04-14T08:42:06Z 置信度 0.70
• Ethical Deliberations on the Gene-Editing CRISPR-Cas9 Designer Babies: Islamic Perspective
  The discovery of the genetic editing tool, CRISPR-Cas9, has enabled us to edit the human genome by removing or adding sections of the DNA. Scientists hope to eradicate some fatal diseases by using this technology. In short, CRISPR allows us to rewrite the code…
  crossref Alya Al Shakaki 2022-09-01T05:31:04Z 置信度 0.70
• CRISPR/Cas Technology: A Climate Saviour or a Genetic Pandora’s Box?
  crossref Aditi Agarwal, Sonika Saxena, Sudipti Arora 2024-03-18T08:02:35Z 置信度 0.70
• Gene Editing in Primary Cells of Cattle and Pig
  crossref Petra Vochozkova, Kilian Simmet, Eva-Maria Jemiller, Annegret Wünsch 等 2019-03-25T09:03:05Z 置信度 0.70
• Increasing Gene Editing Efficiency for CRISPR-Cas9 by Small RNAs in Pluripotent Stem Cells
  Gene manipulations of human induced pluripotent stem cells (iPSCs) by CRISPR-Cas9 genome engineering are widely used for disease modeling and regenerative medicine applications. There are two competing pathways, non-homologous end joining (NHEJ) and homology d…
  crossref Alireza Shahryari, Noel Moya, Johanna Siehler, Xianming Wang 等 2021-08-18T10:00:55Z 置信度 0.70
• Transgenerational CRISPR-Cas9 Activity Facilitates Multiplex Gene Editing in Allopolyploid Wheat
  crossref Wei Wang, Qianli Pan, Fei He, Alina Akhunova 等 2018-02-15T08:44:19Z 置信度 0.70
• Crispr Chronicles: Pioneering Gene Editing in Cardiovascular Therapy
  CRISPR-Cas systems have revolutionized gene editing, offering precise and efficient genome modifications with vast applications in biomedical research and therapeutic interventions. This technology has surpassed traditional methods such as zinc-finger nuclease…
  crossref Yasmeen Yasmeen, Thota Vaishnavi 2025-04-15T05:33:16Z 置信度 0.70
• Will CRISPR gene-editing technology lead to designer babies?
  crossref 2015-12-17T06:45:24Z 置信度 0.70
• Advances and Applications of CRISPR Gene Editing in Tumor Therapy
  crossref Chak Shun Chen 2025-12-24T04:14:02Z 置信度 0.70
• Unexpected gene activation following CRISPR-Cas9-mediated genome editing
  Abstract The discovery of the Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR) and its development as a genome editing tool has revolutionized the field of molecular biology. In the DNA damage field, CRISPR has brought an alternative to induc…
  crossref Anna G Manjón, Hans Teunissen, Elzo de Wit, René H Medema 2021-06-14T16:30:18Z 置信度 0.70
• ISID0901 - Non-viral gene editing therapy for recessive dystrophic epidermolysis bullosa: CRISPR/Cas9 mediated COL7A1 exon 80 deletion strategy
  crossref Xianqing Wang 2023-05-04T12:15:18Z 置信度 0.70
• Beginner’s guide to CRISPR-Cas9-based gene editing
  In the last 20 years since its discovery, clustered regularly interspaced short palindromic repeats (CRISPR) has evolved from a mere bacterial immune system to a tool that can be programmed to achieve directed, efficient and sequence-specific modifications to …
  crossref Shravanti Suresh 2021-06-15T09:57:01Z 置信度 0.70
• Crispr-Based Multiplex Genome Editing in Crop Plants to end Hunger from Planet Earth
  crossref Mubeen Fatima, Sidqua Zafar, Kabeer Haneef, Muhammad Ashar Ayub 等 2025-04-01T15:32:44Z 置信度 0.70
• HBV enfeksiyonunun tedavisinde CRISPR / Cas9 gen düzenleme sisteminin kullanımı
  crossref Medine Karadağ-Alpaslan- 2020-02-21T11:24:01Z 置信度 0.70
• CRISPR-Based Genetic Control Strategies for Insect Pests to Mitigate Classical Insecticidal Approaches
  crossref Falguni Mathur, Asha Arora 2024-03-18T04:02:35Z 置信度 0.70
• Characterization of CsLIEXP1 as a new susceptibility gene to "Xanthomonas citri" subsp. citri and gene editing by CRISPR/Cas9 for citrus canker tolerance
  crossref Reinaldo Rodrigues de Souza Neto 2024-06-05T14:28:51Z 置信度 0.70
• Role of CRISPR-Cas and Its Application in Mitigating Plant Stress
  crossref Sharmistha Ganguly, Akshata G. Athreya, Dhavalkumar Patel 2024-03-18T08:02:35Z 置信度 0.70
• Bacterial Retrons Enable Precise Gene Editing in Human Cells
  Retrons are bacterial genetic elements involved in anti-phage defense. They have the unique ability to reverse transcribe RNA into multicopy single-stranded DNA (msDNA) that remains covalently linked to their template RNA. Retrons coupled with CRISPR-Cas9 in y…
  crossref Bin Zhao, Shi-An A. Chen, Jiwoo Lee, Hunter B. Fraser 2022-01-25T08:52:16Z 置信度 0.70
• H3 Symposium: Gene Editing and Gene Regulation with CRISPR
  crossref Nisha De Souza 2019-12-17T13:52:47Z 置信度 0.70
• Inducible high-efficiency CRISPR-Cas9-targeted gene editing and precision base editing in African trypanosomes
  Abstract The Cas9 endonuclease can be programmed by guide RNA to introduce sequence-specific breaks in genomic DNA. Thus, Cas9-based approaches present a range of novel options for genome manipulation and precision editing. African trypanosomes are parasites t…
  crossref Eva Rico, Laura Jeacock, Julie Kovářová, David Horn 2018-05-15T11:51:11Z 置信度 0.70
• CRISPR gene editing: Can we make cancer cells easier to kill?
  crossref Eric B Kmiec 2024-02-05T18:52:11Z 置信度 0.70
• ADVANCING VEGETABLE CROP IMPROVEMENT: STRATEGIES AND PROSPECTS OF CRISPR-CAS9 GENE EDITING
  crossref 2025-09-24T07:31:07Z 置信度 0.70
• Innovation, Governance, and Crop Genome Editing
  crossref Krishna Ravi Srinivas 2025-05-22T07:43:58Z 置信度 0.70
• Spatial and Temporal Control of CRISPR-Cas9-Mediated Gene Editing Delivered via a Light-Triggered Liposome System
  crossref 2020-11-11T08:25:11Z 置信度 0.70
• Role of Crispr-Cas System in the Development of Climate Smart Crops
  crossref Zulqurnain Khan, Zulfiqar Ali, Asif Ali Khan 2025-04-01T15:32:44Z 置信度 0.70
• License CRISPR patents for free to share gene editing globally
  crossref 2021-09-07T14:03:42Z 置信度 0.70
• New gene editing technique CRISPR-Cas9 raises important ethical questions, says advisory body
  crossref Nigel Hawkes 2016-09-30T10:08:19Z 置信度 0.70
• Spatial and Temporal Control of CRISPR-Cas9-Mediated Gene Editing Delivered via a Light-Triggered Liposome System
  crossref 2020-11-11T08:25:11Z 置信度 0.70
• Beyond CRISPR: TALEN, smart cells, and the regulatory edge in gene editing
  “Success in gene editing is not only about having strong backbones or optimizing specificity, it is also about delivering these tools in a way that ensures performance and precision.”In this discussion, Abi Pinchbeck, Editor, Cell & Gene Therapy Insights, …
  crossref David Sourdive 2025-12-11T16:49:41Z 置信度 0.70
• CRISPR-Cas9 Gene Editing: A Promising Frontier in Revolutionizing Alzheimer’s Disease Management
  Alzheimer’s disease (AD) is a globally devastating neurodegenerative disorder with a significant burden on public health. Currently, the pathophysiology of AD remains uncertain. Meanwhile, conventional pharmacological treatments for AD accomplished with limite…
  crossref Yuxin Jin 2024-06-06T15:52:35Z 置信度 0.70
• CRISPR-Cas9 RNP and rAAV-Mediated Gene Editing in Human Pluripotent Stem Cells v1
  This protocol describes a highly efficient strategy for CRISPR-Cas9–mediated gene editing in human induced pluripotent stem cells (hiPSCs) using Cas9 ribonucleoprotein (RNP) complexes combined with recombinant adeno-associated virus (rAAV)-mediated donor deliv…
  crossref Erdene Baljinnyam, Laura Grisanti, Shalini Tattari, Samuele Marro 2026-06-01T07:11:55Z 置信度 0.70
• Current widely-used web-based tools for CRISPR nucleases, base editors, and prime editors
  crossref Gue-Ho Hwang, Beomjong Song, Sangsu Bae 2021-05-19T01:21:17Z 置信度 0.70
• Current Application of CRISPR/Cas9 Gene-Editing Technique to Eradication of HIV/AIDS
  crossref Prachi Pandey, Jayvadan Patel, Samarth Kumar 2022-05-02T12:47:10Z 置信度 0.70
• Plant Recombinant Gene Technology for Pest Control in the Twenty-First Century: From Simple Transgenesis to CRISPR/Cas
  crossref Ivan Mikhailovich Dubovskiy, Ekaterina Valerievna Grizanova, Sophia Viktorovna Gerasimova 2024-03-18T08:02:35Z 置信度 0.70
• CRISPR Gene Therapy: A Promising One-Time Therapeutic Approach for Transfusion-Dependent β-Thalassemia—CRISPR-Cas9 Gene Editing for β-Thalassemia
  β-Thalassemia is an inherited hematological disorder that results from genetic changes in the β-globin gene, leading to the reduced or absent synthesis of β-globin. For several decades, the only curative treatment option for β-thalassemia has been allogeneic h…
  crossref Udani Gamage, Kesari Warnakulasuriya, Sonali Hansika, Gayathri N. Silva 2023-02-06T05:29:05Z 置信度 0.70
• The Importance of a Novel Product Risk-Based Trigger for Gene-Editing Regulation in Food Animal Species
  crossref Alison L. Van Eenennaam 2018-04-09T10:46:19Z 置信度 0.70
• Lipid Nanoparticles for In Vivo Lung Delivery of CRISPR-Cas9 Ribonucleoproteins Allow Gene Editing of Clinical Targets
  crossref 2025-04-04T08:16:36Z 置信度 0.70
• ‘ChatGPT for CRISPR’ creates new gene-editing tools
  crossref Ewen Callaway 2024-04-29T19:02:13Z 置信度 0.70
• Viral Delivery of Compact CRISPR-Cas12f for Gene Editing Applications
  Treating human genetic conditions in vivo requires efficient delivery of the CRISPR gene editing machinery to the affected cells and organs. The gene editing field has seen clinical advances with ex vivo therapies and with in vivo delivery to the liver using l…
  crossref Allison Sharrar, Zuriah Meacham, Johanna Staples-Ager, Luisa Arake de Tacca 等 2024-05-02T04:45:48Z 置信度 0.70
• Crispr/Cas9 System - A Revolution in Gene Editing
  crossref Teodora Daneva 2019-02-09T06:20:27Z 置信度 0.70
• Gene Editing for Tuberculosis using CRISPR-Cas Technology
  Advances in genome editing technologies are simplifying the tedious, laborious work in research. Recent advancements have introduced innovative genome editing techniques, such as the Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) and CRISPR-…
  crossref Arti Ramdev Sharma, Karuna Gokarn 2026-07-17T05:37:52Z 置信度 0.70
• Gene Editing in Duchene Muscular Dystrophy: From Exon Skipping to CRISPR-based Therapeutic Strategies - A Meta-Narrative Review
  crossref 2026-05-05T16:56:26Z 置信度 0.70
• Gene Editing: Bayer and Crispr Therapeutics form CRISPR/Cas9 technology pact
  crossref 2017-01-10T13:06:17Z 置信度 0.70
• Beyond CRISPR: exploring the next frontier in gene editing technologies
  Abi Pinchbeck, Editor, Cell & Gene Therapy Insights, speaks to Devyn Smith, CEO at Arbor Biotechnologies, about the company’s innovative work in gene editing technologies developed to surpass the limitations of traditional CRISPR/Cas9 methods in addition t…
  crossref Devyn Smith, Abi Pinchbeck 2025-12-16T12:20:26Z 置信度 0.70
• Block Polymer Micelles Enable CRISPR/Cas9 Ribonucleoprotein Delivery: Physicochemical Properties Affect Packaging Mechanisms and Gene Editing Efficiency
  crossref 2020-04-07T19:52:14Z 置信度 0.70
• CRISPR-Cas9 Gene Editing Permanently Eliminates Hiv-1 DNA
  crossref Alexandre Goncalves 2018-03-16T08:51:03Z 置信度 0.70
• Isosteric 3D Bicyclo[1.1.1]Pentane (BCP) Core-Based Lipids for mRNA Delivery and CRISPR/Cas Gene Editing
  crossref 2024-12-10T06:46:23Z 置信度 0.70
• CRISPR for gene editing in neuroscience and neurological disease
  crossref Janine Ostick 2024-03-08T10:54:02Z 置信度 0.70