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• Genomic analysis of Escherichia coli, Enterobacter hormaechei, and Cupriavidus gilardii isolated from Cacatua alba.
  The objective of this study was to perform genomic, phylogenomic, and phenotypic characterization of bacterial isolates from a captive Cacatua alba to investigate their antimicrobial resistance profiles, virulence-associated genes, and genomic relationships wi…
  pubmed de Andrade JP, da Silva Vieira H, Soares CF, Duarte MLO 等 2026 Aug 29 置信度 0.82
• Integrative transcriptomics identifies shared aging-associated inhibitory-neuron states and prioritizes RGL2 across postoperative delirium and Alzheimer's disease.
  Postoperative delirium (POD) and Alzheimer's disease (AD) are increasingly recognized as related neurocognitive conditions, but the aging-associated cell states that may connect them remain poorly defined. Here, we integrated two brain transcriptomic discovery…
  pubmed Fan W, Han S, Wang C, Gao J 2026 Aug 29 置信度 0.82
• Real-World-Feasible Immunohistochemistry of ATRX, DAXX, and Menin Identifies a Subgroup of Non-Functioning Pancreatic Neuroendocrine Tumors with low Recurrence Risk to Guide De-Escalating Surveillance.
  Non-functioning pancreatic neuroendocrine tumors (NF-pNETs) show a variable prognosis. Despite 40-60% of patients remaining recurrence-free after surgery, guidelines recommend ≥ 10 years of follow-up. Recent studies identify prognostic sub…
  pubmed Verschuur AVD, Hackeng WM, Jairam J, Eldem B 等 2026 Aug 29 置信度 0.82
• The identification of a PRKACA duplication at 19p13.12 in a female with PPNAD and thyroid carcinoma after a 20-year diagnostic journey.
  Rare pathogenic variants affecting components of the evolutionary conserved cAMP/protein kinase A (PKA) signalling pathway are implicated in a spectrum of adrenocortical disorders. Germline inactivating PRKAR1A variants leading to constitutive PKA activation, …
  pubmed Broekema MF, Violon F, Vaduva P, Vogel M 等 2026 Aug 29 置信度 0.82
• Identification of ZmGLN5, a candidate gene for resistance to Gibberella ear rot in maize.
  Gibberella ear rot (GER), caused by the fungal pathogen Fusarium graminearum (F. graminearum), severely affects maize yield and grain quality worldwide. Although numerous genetic loci associated with maize resistance to GER have been identified, the functional…
  pubmed Ma L, Ma L, Zhang S, Zhang H 等 2026 Aug 29 置信度 0.82
• A banana susceptibility gene underlying fusarium wilt: validation as a target for disease resistance.
  Fusarium wilt, caused by the soil-borne fungus Fusarium oxysporum f. sp. cubense, remains the principal constraint on banana production, particularly for the widely cultivated cultivar 'Prata-Ana' (AAB) in Brazil. Given the limited efficacy of conventional con…
  pubmed da Silveira Fonseca ML, de Souza Júnior LC, Dos SantosNascimento F, de Souza Ramos AP 等 2026 Aug 29 置信度 0.82
• Identification and characterization of novel alternatively spliced isoforms of the human RAB8B gene.
  Alternative splicing is a key mechanism that expands transcriptomic and proteomic diversity; however, its contribution to the functional complexity of many genes remains poorly understood. RAB8B, a member of the Rab family of small GTPases, plays an important …
  pubmed Sultan I, Rathi A, Rehman SU 2026 Aug 29 置信度 0.82
• The evolution of hereditary cancer genetic counselling: mainstreaming, service redesign and patient experience in Lynch syndrome.
  Genetic counselling for hereditary cancer predisposition has evolved substantially over more than three decades, driven by advances in genomic technologies and the growing use of tumour and germline testing. These developments have expanded access to hereditar…
  pubmed Kohut K, Cable S, Ashokan A, Vicari S 等 2026 Aug 29 置信度 0.82
• High levels of cell-free hemoglobin and iron in cerebral thrombi of pre-Omicron COVID-19 stroke patients: novel drivers of SARS-CoV-2-induced prothrombotic state.
  The pathophysiological mechanisms underlying the hypercoagulable state and thrombotic events associated with COVID-19 remain incompletely understood. To investigate prothrombotic alterations during SARS-CoV-2 infection, we performed an exploratory and integrat…
  pubmed Payá M, Alcahut-Rodríguez C, Barbella-Aponte RA, Hernández-Fernández F 等 2026 Aug 29 置信度 0.82
• Association between antidepressant use and the risk of type 2 diabetes: a multi-stage Mendelian randomization study.
  Depression is a highly prevalent condition, and antidepressants are widely used to manage its symptoms. However, concerns have emerged regarding a potential causal relationship between antidepressant use and the development of type 2 diabetes (T2D). Understand…
  pubmed Liu D, Baranova A, Xu C, Sun W 等 2026 Aug 29 置信度 0.82
• Adaptive Laboratory Evolution of the Hydrocarbonoclastic Marine Strain Rhodococcus ruber MSA14 to High Pyrene Concentrations.
  Rhodococcus ruber MSA14, isolated from oil-polluted coastal sediments in Baja California, Mexico, has previously been shown to degrade pyrene, highlighting its potential for polycyclic aromatic hydrocarbons (PAH) bioremediation. In the present study, MSA14 was…
  pubmed Calcáneo-Hernández G, Embarcadero-Jiménez S, Silva-Jiménez H, Georgellis D 2026 Aug 29 置信度 0.82
• Isolation and Characterization of Sphingopyxis sp. Q841: A New Zearalenone- Degrading Strain.
  Zearalenone (ZEN) is a mycotoxin exhibiting estrogenic activity that poses a considerable risk to human health. In this study, a ZEN-degrading bacterium isolated from soil was identified as Sphingopyxis sp. and designated strain Q841. Q841 completely degraded …
  pubmed Chen Q, Hu J, Wang G, Wu Y 等 2026 Aug 29 置信度 0.82
• Using human proteomic and lipidomic to exploration drug target of bladder cancer.
  The goal of this study is to explore the genetic predictive associations between plasma proteomics and bladder cancer using the Mendelian randomization (MR) method, and to investigate whether plasma lipidomics characteristics mediate these associations.
  pubmed Cao Q, Liu H, Xu Y, Wang Y 等 2026 Aug 29 置信度 0.82
• MAD2B guides chromosome stability in mitosis via the MAD2B-CIP2A signaling axis.
  Error-free mitosis depends on accurate chromosome attachment to spindle microtubules, monitored by the spindle assembly checkpoint machinery, which prevents precocious chromosome segregation and reduces the risk of aneuploidy. MAD2B, a homologue of MAD2, is cr…
  pubmed Ejaz U, Xiong F, Shao H, Ullah T 等 2026 Aug 29 置信度 0.82
• Risk of Myocarditis and Pericarditis With Bivalent RSV Prefusion F Protein-Based Vaccine: A Safety Analysis of the Extended DAN-RSV Trial.
  pubmed Yafasov M, Lassen MCH, Pareek M, Christensen SH 等 2026 Aug 29 置信度 0.82
• Adjuvant CDK4/6 inhibitors in early-stage breast cancer: Clinical evidence and considerations for risk stratification and treatment selection.
  Hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer is the most common biologic subtype and carries a persistent risk of recurrence, particularly in patients with high-risk, early-stage disease. Cyclin-dependent kinase 4 …
  pubmed Williams AD, Weiss A 2026 Sep 1 置信度 0.82
• Development and external validation of the SCORE2 models in Latin America and the Caribbean (SCORE2-LAC) to estimate 10-year cardiovascular disease risk.
  Despite the high burden of cardiovascular disease (CVD) in Latin America and the Caribbean (LAC), risk prediction models adapted for use in LAC populations remain limited. The aim of this study was to recalibrate the Systematic COronary Risk Evaluation 2 (SCOR…
  pubmed Bijkerk S, Ponte-Negretti CI, Maung KK, Friedrichs LG 等 2026 Aug 29 置信度 0.82
• Contactless Co-Culture Assays for Morphometric Studies During Inter-Species Interactions in Fungi.
  Cellular behaviour and morphology are usually influenced by various intra- and extracellular factors in a microbial community. Different approaches available to study microbial communication could be tedious and/or require specialised facilities and expertise.…
  pubmed Parnandi VA, Swamy KBS, Patkar RN 2026 Aug 28 置信度 0.82
• Epigenomic Landscape of Oak (Quercus robur) across Season and Generation.
  Seasonal fluctuations strongly shape the physiology of long-lived trees by coordinating growth, dormancy, and stress responses. Increasing evidence points to epigenetic mechanisms, particularly DNA methylation, as regulators of these processes, yet their role …
  pubmed Sanchez-Lucas R, He J, Chirico M, Bosanquet JL 等 2026 Aug 29 置信度 0.82
• SHMT2: a Metabolic and Immune Biomarker of Aggressive Lung Adenocarcinoma.
  Serine/glycine-one-carbon (SGOC) metabolism is frequently altered in lung adenocarcinoma (LUAD), but its relationship to tumor behavior and predicted immunotherapy responsiveness remains incompletely defined. Metabolomic profiling of 23 paired LUAD and adjacen…
  pubmed Zhang Y, Nuo Y, Zhang D, Wang S 等 2026 Aug 28 置信度 0.82
• Expanding the diagnostic lens: Whole exome sequencing in a neonate with arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome.
  We report a term neonate who presented with early-onset conjugated hyperbilirubinemia, acholic stools, and imaging findings concerning for biliary atresia, including a contracted gallbladder and triangular cord sign on abdominal ultrasound. However, intraopera…
  pubmed Sreenivasan G, Hedrick J, Ware A, Leong M 2026 Aug 29 置信度 0.82
• Explainable Plasma Proteomics-Based Machine Learning for Osteoporosis Diagnosis, Prognosis, and Protein Biomarker Discovery in the UK Biobank.
  Osteoporosis (OP) is often underdiagnosed, highlighting the need for tools that can both detect existing disease and predict future risk; large-scale plasma proteomics combined with explainable machine learning enables integrated diagnostic and prognostic mode…
  pubmed Zhang W, Zhang W, Cheng H, Gong W 等 2026 Sep 15 置信度 0.82
• Between myopathy and mortality: Challenges in the diagnosis of PLOD1-related kyphoscoliotic Ehlers-Danlos syndrome.
  ObjectivePLOD1-related kyphoscoliotic Ehlers-Danlos syndrome (kEDS) is a rare autosomal recessive connective tissue disorder characterized by generalized joint laxity, severe congenital hypotonia, progressive kyphoscoliosis, hyperextensible and easily bruised …
  pubmed Vill K, Brunet T, Brugger M, Wagner M 等 2026 Aug 29 置信度 0.82
• Explainable Deep Learning of Transcriptomes Prioritizes Candidate Biomarkers With Preferential Performance in Gastric Cardia Cancer Cohorts.
  Gastric cardia adenocarcinoma is biologically distinct from distal disease, but deployable molecular markers remain scarce. We investigated whether explainable deep learning applied to public transcriptomes could nominate diagnostic and survival-associated can…
  pubmed Xu J, Li C 2026 Sep 15 置信度 0.82
• An Integrated Proteomics and Genomics Approach to Identify Essential Protein Kinases During Human Trophoblast Development.
  In the developing human placenta, three subtypes of trophoblast cells, cytotrophoblasts (CTBs), extravillous trophoblasts (EVTs), and syncytiotrophoblasts (STBs), mediate critical functions essential for a successful pregnancy. CTBs constitute the stem/progeni…
  pubmed Kumar R, Dasgupta P, Ray S, Paul S 2026 Sep 15 置信度 0.82
• Haplotype-phased assemblies of the two poplar rust fungi species: Melampsora larici-populina and Melampsora allii-populina.
  Dikaryotic rust fungi maintain two distinct haploid nuclei for most of their life cycle, making their large, repeat-rich genomes difficult to assemble and phase. Here we present haplotype-phased, near chromosome-scale genome assemblies for the poplar rust path…
  pubmed Corre E, Morin E, Sperschneider J, Abdalrahem A 等 2026 Aug 29 置信度 0.82
• Genetic determinants that permit growth without the core septin Cdc12 in Cryptococcus neoformans.
  Septins are conserved cytoskeletal GTPases that regulate morphogenesis, cytokinesis, and cell-surface organization in fungi. In most model and pathogenic yeasts, including Saccharomyces cerevisiae and Candida albicans, core septin subunits such as Cdc3 and Cdc…
  pubmed Stempinski PR, Akahoho HS, Noorai RE, Shankar V 等 2026 Aug 29 置信度 0.82
• Pharmacological readthrough and base editing for ANK1 nonsense mutations in an erythroid model of hereditary spherocytosis.
  Hereditary spherocytosis (HS) is the most common inherited chronic hemolytic anemia and results from defects in proteins of the erythrocyte membrane skeleton. Nonsense mutations in ANK1 are a common cause of HS, yet current treatments remain largely supportive…
  pubmed Li S, Li J, Shi W, Nie Z 等 2026 Sep 8 置信度 0.82
• Long-read target enrichment sequencing for rAAV integration site analysis in engineered clones with targeted viral insertion.
  Integration site analysis (ISA) plays a critical role in the genotoxicity assessment of recombinant adeno-associated viruses (rAAVs); however, ISA is challenged by the low integration rate, frequent vector genome rearrangements and the absence of well-characte…
  pubmed Coratella E, Lemmens M, Oertli M, Gilbart Y 等 2026 Sep 8 置信度 0.82
• Re-emergence of Conventional Drug Susceptibility Amid Persistent Fluoroquinolone Resistance in Enteric Fever.
  Background Fluoroquinolone resistance among Salmonella isolates causing enteric fever has emerged as a major therapeutic challenge in India. The present study evaluated the clinical profile, antimicrobial susceptibility patterns and genomic mechanisms of …
  pubmed Sengupta M, R S S, Parvin S, Chatterjee SS 等 2026 Jul 置信度 0.82
• The Effect of MEG3 Promoter Methylation on MEG3 Expression in Acute Myeloid Leukemia: Assessment by High-Resolution Melting (HRM) Analysis.
  Epigenetic mechanisms play a crucial role in regulating genome expression and are subject to dysregulation in leukemia, hence exerting a significant impact on the pathogenesis of this malignancy. Maternally expressed gene 3 (MEG3), a long non-coding RNA, has b…
  pubmed Asgharzadeh A, Moradabadi A, Noroozi-Aghideh A 2026 置信度 0.82
• A near telomere-to-telomere genome assembly of Isatis indigotica L. facilitates phylogenomic studies in tribe Brassiceae.
  pubmed Zhang X, Wang Y, Yu P, Yang T 等 2026 Sep 置信度 0.82
• Designing a multi-epitope vaccine against dengue virus-2 using in silico tools for expression in plant systems.
  Dengue virus (DENV), transmitted by Aedes mosquitoes, remains a serious global health threat with an increasing incidence, largely due to its complex epidemiology and the impact of climate change. DENV belongs to the Flaviviridae family, comprising four seroty…
  pubmed Shokoohi M, Manteghi Tafreshi A, Mokarami M, Akhavan S 等 2026 置信度 0.82
• Genetic dissection of the eggplant rhizosphere microbiome enables microbiome-assisted breeding.
  Rhizosphere microbiome critically influences plant growth and health, yet the genetic mechanisms underlying host regulation of microbiome composition remain unclear. Here, we analyzed whole-genome genotype and 16S rhizosphere microbiome data from 432 globally …
  pubmed Li Y, Li W, Gan G, Wang X 等 2026 Sep 置信度 0.82
• Characterization and Therapeutic Potential of a Novel Bacteriophage Targeting Methicillin-Resistant Staphylococcus aureus Biofilms on Medical Devices.
  Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of multidrug-resistant and biofilm-associated infections, particularly on indwelling medical devices, where conventional antibiotics often exhibit limited efficacy. In this study, we isolated …
  pubmed Niloy RK, Mondal SI, Jewel NA, Zaeem I 等 2026 置信度 0.82
• Two Cases of Multiple Sclerosis in a Family With X-Linked Charcot-Marie-Tooth Disease.
  The aim of this study was to present a case report of the first familial case of multiple sclerosis (MS) in an X-linked Charcot-Marie-Tooth family with a novel variant in GJB1 .
  pubmed Menih M, Hojs Fabjan T, Maver A, Peterlin B 2026 Oct 置信度 0.82
• Severe Transfusion-Dependent Infantile Hemolytic Anemia Associated With a Novel Homozygous PKLR Variant of Uncertain Significance (c.1376C>G, p.Ala459Gly) and Coexisting G6PD Deficiency: A Case Report.
  Pyruvate kinase deficiency (PKD) results from pathogenic variants in the PKLR gene and demonstrates marked clinical heterogeneity ranging from compensated hemolysis to severe transfusion-dependent anemia; however, novel variants continue to expand the gen…
  pubmed Hassanien SS, Alasmari BG, Hanafy E, Mansour M 等 2026 Jul 置信度 0.82
• Genome-wide identification of GhAOX gene family and its expression and regulation in cotton CMS line Jin A.
  Alternative oxidase (AOX) is a core functional protein that mitigates excessive mitochondrial reactive oxygen species (ROS) accumulation and modulates plant stress adaptation, and its biological activity is tightly controlled by sophisticated regulatory networ…
  pubmed Zhang J, Zhang L, Su Y, Shi J 等 2026 置信度 0.82
• Chloroplast genome sequence and phylogenetic analysis of the hemiparasitic plant: Taxillus sutchuenensis var. duclouxii (Loranthaceae).
  Taxillus sutchuenensis var. duclouxii , a shrub-like hemiparasitic plant with medicinal value. This study sequenced, assembled, and annotated the chloroplast genome of T. sutchuenensis var. duclouxii using Illumina high-throughput sequencing. The genome exhibi…
  pubmed Zhao J, Liang W, Huang R, Wu H 等 2026 置信度 0.82
• Exploratory proteomic biomarker combinations associated with post-concussion symptoms following a concussion in adolescents.
  This study examined the ability of established brain biomarkers, glial fibrillary acid protein (GFAP), neuro-filament light chain (NFL), ubiquitin carboxy hydrolase-L1(UCH-L1), tau, and phosphorylated tau (p-tau), and novel biomarkers from blood collected sub-…
  pubmed Gill J, Lim A, Dennis E, Bickart K 等 2026 置信度 0.82
• A PepFect14 analog improves non-viral CRISPR delivery in primary human cells to facilitate genome editing and repair.
  CRISPR-based designer nucleases can facilitate genome engineering targeting almost any genomic locus. However, safe and efficient methods for delivering gene editors into primary human cells and tissues remain a central challenge. In this study, we employed a …
  pubmed du Rand A, Masterson C, Verdon D, Siow A 等 2026 置信度 0.82
• Tumor-specific KCNJ5 mutation in an aldosterone-producing adenoma not detected in adrenal venous plasma cell-free DNA.
  Circulating tumor DNA (ctDNA) can be detected in adrenocortical carcinoma; however, its detectability in benign adrenal tumors, such as aldosterone-producing adenoma (APA), remains unclear. We investigated whether tumor-specific mutations could be detected in …
  pubmed Aono D, Kato T, Kometani M, Yoneda T 等 2026 Sep 置信度 0.82
• Squash enables Spindle-E-dependent heterotypic piRNA amplification in the Drosophila ovary.
  The PIWI-interacting RNA (piRNA) pathway represses mobile transposable elements (TEs) to protect genome integrity in animal gonads. In Drosophila ovaries, piRNAs are generated in the nuage, a membrane-less organelle enriched with piRNA factors. Squash (Squ) is…
  pubmed Xu X, Iki T, Kawaguchi S, Kai T 2026 Aug 21 置信度 0.82
• Hepatitis C virus-associated B-cell non-Hodgkin lymphomas: immune evasion, multistep lymphomagenesis, and candidate biomarkers for risk stratification and disease monitoring.
  Hepatitis C virus (HCV)-associated B-cell non-Hodgkin lymphomas represent a compelling model of virus-driven oncogenesis in which immune evasion and viral persistence sustain chronic antigenic stimulation, B-cell clonal expansion and progressive multistep lymp…
  pubmed Carloni G, Ponzetto A, Rinaldi M 2026 置信度 0.82
• Molecular insights and integrated management of Glomerella leaf spot in apple.
  Apple ( Malus × domestica ) is one of the world's premier fruit crops. Apple Glomerella leaf spot (GLS) is caused by Colletotrichum spp., jeopardizing global apple supply and incurring millions of dollars in annual losses. The development of…
  pubmed Rahman MU, Bai S, Khamdullaev SA, Aytenov ISU 等 2026 Sep 置信度 0.82
• The HD-ZIP I transcription factor BcLMI1 regulates bolting time in Brassica campestris by repressing BcTCP4.
  During the domestication of Brassica campestris (syn. Brassica rapa ), significant variations in bolting time have emerged, critically impacting crop yield and quality. To elucidate the genetic basis of bolting time regulation in B. campestris , we integrated …
  pubmed Chen J, Wu Y, Li A, Tian Y 等 2026 Sep 置信度 0.82
• Evaluation of the effect of hydroquinidine on ST segment in Brugada syndrome using 12-lead Holter monitoring.
  pubmed Chiswell K, Isbister JC, Kirby A, Cham J 等 2026 Aug 置信度 0.82
• Chromosome movements in meiotic prophase: regulatory mechanisms and biological roles.
  Meiotic prophase is characterized by dynamic chromosome movements that are essential for accurate genome transmission and the generation of genetic diversity. During this stage, chromosome ends, typically telomeres or other specialized chromosomal domains, att…
  pubmed Zhao L, Gao J 2026 置信度 0.82
• Bounding the Average Move Structure Query for Faster and Smaller RLBWT Permutations.
  The move structure represents permutations with long contiguously permuted intervals in compressed space with optimal query time. They have become an important feature of compressed text indexes using space proportional to the number of Burrows-Wheeler Transfo…
  pubmed Brown NK, Langmead B 2026 置信度 0.82
• Causal effect of gastroesophageal reflux disease on cataracts: A mendelian randomization study.
  Cataracts, the leading cause of blindness globally, have been linked to genetic variants in regions also implicated in gastroesophageal reflux disease (GERD), suggesting potential pleiotropic effects. While observational studies have hinted at a possible assoc…
  pubmed Chen Y, Wu X, Ou J, Zhuang W 等 2026 Aug-Sep 置信度 0.82
• Mitochondrial genomic variation, evolutionary dynamics, and phylogeny of forest-associated Phytophthora species in the Qinling Mountains of China.
  The genus Phytophthora (Oomycota) comprises highly destructive and widely distributed plant pathogens that threaten global agriculture and forest ecosystems; however, the evolutionary significance of intraspecific and interspecific mitogenomic variation within…
  pubmed Sun Y, Chen X, Wang W, Li Y 等 2026 置信度 0.82
• Investigating Genetic Spillage in a Mimulus cardinalis (Syn. Erythranthe cardinalis) Common Garden Experiment.
  Common gardens are critical to studying the trait variations in plant species and how environmental or genetic factors influence them. In common gardens, non-native species and non-local populations must be monitored closely to reduce their chances of escaping…
  pubmed Duran L, Ramadoss N, Sheth SN, Flores-Rentería L 2026 Sep 置信度 0.82
• Molecular evolution and functional divergence of CsAlaDC from CsSDC reveal key determinants for theanine biosynthesis in tea plants.
  Theanine, a non-protein amino acid predominantly found in tea ( Camellia sinensis ), is a primary contributor to the characteristic umami and sweet taste of tea infusion and is associated with numerous health benefits. The biosynthesis of its direct precursor,…
  pubmed Zhou H, Bai P, Wang Y, Wang Y 等 2026 Sep 置信度 0.82
• Bioinformatics-based identification of potential genes in the thalamus associated with chronic orofacial and somatic inflammatory pain.
  The thalamus is one of the structures that receives projections from multiple ascending pain pathways. Although the transmission of orofacial and somatic pain involves different nuclear clusters and nerve pathways, the thalamic neuroimmune alterations across t…
  pubmed Cheng Y, Yuan JJ, Liu J, Guo XY 等 2026 置信度 0.82
• Evaluating high-fidelity CRISPR-Cas nucleases in nucleosomal contexts using a quantitative framework.
  Chromatin presents a significant obstacle to CRISPR-Cas gene editing, as chromatin restricts nuclease access to DNA. Recent advances have produced a wide range of high-fidelity Cas9 and Cas12a variants with enhanced properties. However, their precision in targ…
  pubmed Handelmann CR, Skeens E, Lisi GP, Buck MJ 2026 置信度 0.82
• Haplotype-resolved regulation of secondary metabolism in cannabis.
  Cannabis sativa produces a rich array of specialized metabolites, including cannabinoids, terpenoids, and flavonoids, which are of immense therapeutic interest. However, the genetic and regulatory complexity arising from its highly heterozygous genome has obsc…
  pubmed Cai S, Zhang Z, Li X, Zhao Y 等 2026 Sep 置信度 0.82
• Genome-wide characterization of the wheat cryptochrome/photolyase family identifies TaCRY1b as a lamina-joint-associated protein interacting with TaLG2 and TaLG2L.
  Cryptochromes (CRYs) are blue light and ultraviolet A (UV-A) photoreceptors that play pivotal roles in regulating plant development and stress responses through mediating light signaling pathways. However, the evolutionary and functional characteristics of the…
  pubmed Gu B, Wang Y, Liu C, Niu Z 等 2026 置信度 0.82
• The syntrophic network of pyrene degradation by the synthetic halophilic consortium PES.
  Owing to the high osmotic pressure, the degradation of high-molecular-weight polycyclic aromatic hydrocarbons (HMW-PAHs) in saline environments is quite difficult, leading to a scarcity of research on halophilic PAH-degrading bacteria. In this study, a halophi…
  pubmed Wen Y, Lu H, Wang L, Zhao H 等 2026 置信度 0.82
• The dynamics of ciliogenesis in prepubertal mouse meiosis reveals new clues about testis maturation.
  Primary cilia have recently been identified in mammalian spermatocytes, but their developmental regulation during testicular maturation remains poorly understood. Here, we investigate the dynamics of ciliogenesis during mouse puberty and show that primary cili…
  pubmed Pérez-Moreno I, López-Jiménez P, Zapata-Polo H, Pérez-Martín S 等 2026 置信度 0.82
• Global Hypomethylation in Cell-Free DNA Enables Noninvasive Colorectal Cancer Screening: Results from a Retrospective Validation Study.
  Global DNA hypomethylation is a defining hallmark of colorectal cancer (CRC) but is poorly captured by existing cell-free DNA (cfDNA) technologies, which typically interrogate only a fraction of CpG sites and are biased toward CpG islands. Asima Rev is a rapid…
  pubmed Kaur S, Lathwal S, Agrawal S, Mahmoudi T 等 2026 置信度 0.82
• Editorial: What's on the Horizon for asthma treatment?
  pubmed Novelli L, Maniscalco M, Bouloukaki I 2026 置信度 0.82
• Discovery of a defence-response gene for Eldana saccharina resistance in sugarcane.
  Eldana saccharina is a major stalk boring pest of sugarcane in South Africa, causing substantial yield and revenue losses. Developing sugarcane cultivars with durable resistance to E. saccharina is therefore a priority for breeding programmes. In this study, w…
  pubmed Jacob RM, Ghai M, Joshi SV 2026 置信度 0.82
• Investigation of complex miRNA-mRNA interaction networks during JAK inhibitor therapy in rheumatoid arthritis.
  MicroRNAs (miRNAs) are small molecules that contribute to the regulation of gene expression by binding to messenger RNAs (mRNAs), controlling the amount of proteins being produced. In the past few decades, biologic and targeted synthetic therapies (e.g., Janus…
  pubmed Rózsa J, Csige D, Bodoki M, Hagymási-Szabó Z 等 2026 置信度 0.82
• Harnessing epistatic architecture to improve genomic selection accuracy for soybean pod number.
  Soybean ( Glycine max [L.] Merr.) is a globally critical oilseed and protein crop, and pod number per plant (PN) is a core determinant of soybean grain yield. Conventional genomic selection (GS) for PN almost exclusively focuses on additive genetic effects, le…
  pubmed Dong L, Zhang R, Jiang H, Zhu X 等 2026 Sep 置信度 0.82
• Exercise alone or combined with functional foods in aging and age-related diseases: targeting DNA damage, repair pathways, and genome integrity.
  Aging is fundamentally associated with the gradual accumulation of DNA damage, which is instrumental in the initiation and advancement of age-associated pathologies, including neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease. Re…
  pubmed Ma Y, Li X, Chen H, Fan R 2026 置信度 0.82
• From capability uplift to capability governance: an AI-biosecurity stack.
  Artificial intelligence is becoming a general-purpose enabling technology for the life sciences. AI-enabled tools can strengthen biosecurity and biodefense by improving early warning, accelerating vaccine and therapeutic discovery, supporting laboratory safety…
  pubmed Luhachack L, Connell N, Berger K 2026 置信度 0.82
• Therapy-related acute myeloid leukemia with 24-month latency after CD19 CAR-T cell therapy in relapsed/refractory diffuse large B-cell lymphoma: a case report.
  Therapy-related myeloid neoplasms (t-MNs) have emerged as a serious late complication of CD19-directed chimeric antigen receptor (CAR) T-cell therapy. While large-scale studies have characterized the epidemiology of t-MNs, the mechanisms underlying their devel…
  pubmed Su M, Huang C, Zhang Z, Wang X 等 2026 置信度 0.82
• Type 17 T-cell subset divergence in hidradenitis suppurativa versus psoriasis: a comparative single-cell transcriptomic analysis.
  IL-17-producing Type 17 T (T17) cells are central drivers of inflammation in both psoriasis and hidradenitis suppurativa (HS), as evidenced by the clinical efficacy of IL-17-targeting therapies. However, therapeutic responses differ substantially between disea…
  pubmed Park N, Lee J, Kim D, Rambhia D 等 2026 置信度 0.82
• Commentary: Re-calibration of flow cytometry standards for plant genome size estimation.
  pubmed Martin SL, James T, Sears E, Bainard JD 等 2026 置信度 0.82
• Traits analysis of an aphid-killing Pantoea agglomerans strain for use in biological control.
  In crop pest control, microbial bioinsecticides are considered promising for overcoming the critical limitations of traditional chemical pesticides regarding environmental and health impact. In this study, we report a strain of Pantoea agglomerans (ELIV) letha…
  pubmed Hamidović A, Ghisdal N, Dhondt L, Pons I 等 2026 置信度 0.82
• Editorial: Microbial solutions for soil health and remediation: from natural diversity to engineered communities.
  pubmed Zhuo R, Zhang X 2026 置信度 0.82
• Inhibition of ATM, ATR and DNA-PK radiosensitises 3D uveal melanoma models to X-rays and proton beam therapy.
  Proton beam therapy (PBT) is a well-established treatment modality for uveal melanoma (UM), where it exerts its therapeutic effect primarily through the induction of significant DNA damage, particularly DNA double strand breaks (DSBs) that are the most challen…
  pubmed Hawkins L, Morris R, Kalirai H, Aughton K 等 2026 置信度 0.82
• Plasma proteomics reveals the molecular features in rapidly progressive pneumoconiosis.
  Rapidly progressive pneumoconiosis (RPP) is an aggressive subtype of pneumoconiosis characterized by persistent pulmonary inflammation, rapidly progressive fibrosis, and early-onset progressive massive fibrosis. However, the systemic molecular alterations of R…
  pubmed Tang M, Luo Y, Li Y, Tang W 等 2026 置信度 0.82
• Beyond genes: CRISPR/Cas9 for chromosomal engineering in polyploids.
  pubmed Jamil M, Mqabool R, Khan SH, Huang WQ 等 2026 置信度 0.82
• A novel LepR knockout hamster model for type 2 diabetes and its complications: a complementary platform to conventional rodent models.
  Type 2 diabetes (T2D) is a progressive metabolic disorder characterized by systemic metabolic dysfunction and multi-organ complications that considerably increase morbidity and mortality. Leptin signaling via leptin receptor (LepR) is vital for maintaining ene…
  pubmed Tang X, Lu J, Long L, Huang M 等 2026 置信度 0.82
• Complex landscape of somatic copy number alterations in head and neck paragangliomas.
  Copy number alterations (CNAs) drive cancer by amplifying oncogenes and deleting tumor suppressor genes. Although CNA patterns are well-studied in common cancers, they remain poorly characterized in rare tumors.
  pubmed Pavlov VS, Fedorova MS, Elnukaev TSM, Kalinin DV 等 2026 置信度 0.82
• Stroke in non-bacterial thrombotic endocarditis: a patient-level systematic review of clinical characteristics, management, and outcomes.
  Stroke is a frequent manifestation of non-bacterial thrombotic endocarditis (NBTE), yet current knowledge largely stems from case reports and small case series. This systematic review summarizes stroke presentation, imaging features, management, and outcomes i…
  pubmed Aljabali A, Alhayali D, Taylor-Wedge H, Laffaye TA 等 2026 置信度 0.82
• Cancer Genomics
  crossref Marcelo A. Marti 2026-08-21T14:23:02Z 置信度 0.70
• Mitochondrial Genomics
  crossref 2026-08-21T10:03:00Z 置信度 0.70
• Introduction to Clinical Genomics
  crossref Marcelo A. Marti 2026-08-21T14:28:25Z 置信度 0.70
• 2026 Bundibugyo virus outbreak: the role of genomics in Orthoebolavirus outbreaks
  Central Africa is currently experiencing its third recorded outbreak of Bundibugyo virus, one of three orthoebolaviruses capable of causing lethal haemorrhagic fevers in humans with person-to-person transmission. The first genomes from this outbreak have been …
  crossref Charlotte J. Houldcroft 2026-06-05T15:16:32Z 置信度 0.70
• Population Genomics and Genetic Diversity
  crossref Marcelo A. Marti 2026-08-21T14:28:27Z 置信度 0.70
• Meet the author: Jiarui Ding
  crossref Jiarui Ding 2026-06-10T15:07:22Z 置信度 0.70
• Meet the author: Junyue Cao
  crossref Junyue Cao 2026-03-11T15:09:41Z 置信度 0.70
• Copyright
  crossref 2026-08-21T10:09:42Z 置信度 0.70
• Editorial Board
  crossref 2026-05-07T15:06:07Z 置信度 0.70
• Editorial Board
  crossref 2026-03-19T16:09:52Z 置信度 0.70
• Editorial Board
  crossref 2026-05-20T18:13:52Z 置信度 0.70
• Editorial Board
  crossref 2026-04-01T14:42:37Z 置信度 0.70
• Corrigendum
  crossref 2026-01-02T08:40:21Z 置信度 0.70
• Editorial Board
  crossref 2026-06-22T17:34:08Z 置信度 0.70
• Editorial Board
  crossref 2026-02-18T15:41:33Z 置信度 0.70
• Editorial Board
  crossref 2026-08-26T14:32:23Z 置信度 0.70
• Editorial Board
  crossref 2026-07-28T18:10:27Z 置信度 0.70
• Index
  crossref 2026-08-21T10:09:42Z 置信度 0.70
• Contents
  crossref 2026-08-21T10:09:42Z 置信度 0.70
• Meet the author: Nathan D. Olson
  crossref Nathan D. Olson 2026-04-08T16:26:17Z 置信度 0.70
• Title page
  crossref 2026-08-21T10:09:42Z 置信度 0.70
• Applications and Challenges of Epigenetic Signature Detection in the Diagnostic Genomics Laboratory–Current and Future Directions
  Background Epigenetic signature detection (ESD) identifies disease‐associated DNA methylation patterns and offers valuable insights beyond traditional genomic testing. Episignatures are increasingly recognised for their diagnostic potential, particularly in ra…
  crossref Amy Harte 2026-03-21T05:01:32Z 置信度 0.70
• Duplicate, diversify, repeat: The evolution of NOTCH2NL
  crossref Nachshon Egyes, David Gokhman 2026-06-10T15:07:22Z 置信度 0.70