-
europepmc
2026
置信度 0.80
-
ESKAPE pathogens are major causes of hospital-acquired infections and are characterized by extensive antimicrobial resistance (AMR) and diverse virulence mechanisms. Although species-specific pan-genome studies have revealed substantial genomic diversity, the …
pubmed
Singh S, Kumar P
2026
置信度 0.82
-
europepmc
2026
置信度 0.80
-
Hormone-producing cells in the pancreas and intestine regulate whole-body metabolism and are dysregulated in obesity and diabetes. A deeper understanding of endocrine lineage formation (endocrinogenesis) in these organs is essential to elucidate the healthy st…
pubmed
Jing C, Sterr M, Caliskan ÖS, Saber L 等
2026 Aug 30
置信度 0.82
-
Understanding the cortical architecture underlying individual differences in general cognitive ability (GCA) remains a central question in cognitive neuroscience. Prior work has established associations between global brain size and GCA, yet the regional effec…
pubmed
Chou CJ, Fiecas M, Del Re EC, Vuoksimaa E 等
2026 Sep
置信度 0.82
-
Polycaprolactone (PCL) is a biodegradable polyester widely used in industry, but it degrades slowly in the environment. Enzymatic hydrolysis catalyzed by cutinases represents a promising approach for PCL waste utilization. Through screening, we selected the Au…
pubmed
Ermilov FK, Eneiskaya EV, Panasenko SA, Zhurishkina EV 等
2026 Aug
置信度 0.82
-
The transcription factor c-Myc is frequently upregulated in human cancers through multiple mechanisms, including chromosomal translocation and gene amplification. Since the human TRIB1 gene is located on chromosome 8q24 in close proximity to the MYC oncogene, …
pubmed
Suzuki Y, Nagasaka M, Miyajima C, Tsuzuki K 等
2026
置信度 0.82
-
Cancer immunotherapy using patient-derived T cells genetically modified in vitro has been demonstrated to be effective. However, issues such as cost, time, and unstable quality must be resolved. To overcome these barriers, we developed the TCR-PS cell method, …
pubmed
Kawamoto H, Kawase T, Nagano S
2026
置信度 0.82
-
Fertilization depends on the proper formation and function of the acrosome, a specialized organelle essential for sperm-oocyte interaction. Defects in acrosome biogenesis impair fertilization and cause severe male infertility, including globozoospermia. Howeve…
pubmed
Shimada K, Qiu Y, Kaneda Y, Pham AH 等
2026 Aug 28
置信度 0.82
-
Aspergillus fumigatus strains cause severe mycosis in humans. Strains belonging to the cryptic species of A. fumigatus, such as Aspergillus lentulus, are also pathogenic and tend to exhibit resistance to azole drugs. Although the contribution of cytochrome P45…
pubmed
Yoshioka I, Cao W, Yaguchi T
2026
置信度 0.82
-
We recently identified a domestic cat hepatitis B virus (DCHBV) outbreak at a cat shelter in Okinawa, Japan. Viral genome sequencing showed that this particular strain was highly conserved and distinct from previously reported Japanese strains, suggesting that…
pubmed
Houri YY, Kato NX, Adachi Y, Kawano MX 等
2026 Aug 28
置信度 0.82
-
G-quadruplexes (G4s) have emerged as one of the most exciting nucleic acid secondary structures. G-quadruplexes are non-canonical, four-stranded nucleic acid structures formed in sequences with consecutive runs of guanine bases. Unlike duplex DNA, G-quadruplex…
pubmed
Dickerhoff J, Yang D
2026 Aug-Oct
置信度 0.82
-
Cervical cancer (CC) remains a public health challenge in developing countries. Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase highly expressed in CC. Studies showed that PGE2 may transactivate EGFR in some models. However, understanding…
pubmed
de Azevedo VR, Guimarães IDS, Farrapo MJ, Martins-Cardoso K 等
2026 Aug 30
置信度 0.82
-
Transposable elements (TEs) (mobile genetic elements comprising ~45% of the human genome) have recently emerged as potential contributors to Parkinson's disease (PD); however their role and sex-specific impact remain poorly understood. Here, we present the fir…
pubmed
Gordillo-González F, Galiana-Roselló C, Grillo-Risco R, Soler-Saéz I 等
2026 Aug 30
置信度 0.82
-
Host structural variations (SVs) are critical in cancer development but their landscape and interaction with HPV integration in cervical carcinogenesis remain unclear. In this study, we performed Nanopore long-read sequencing on five HPV-positive cervical canc…
pubmed
Hao S, Yang S, Zhao Q, Jiang L 等
2026 Aug 30
置信度 0.82
-
Among the several Asian Aedes species that have established in Europe over recent decades, Aedes koreicus has received comparatively little research attention since its first detection in Belgium in 2008, despite its remarkable ability to colonise montane and …
pubmed
Marini G, Mancini MV, Damiani C, Kurucz K 等
2026 Aug 30
置信度 0.82
-
Soil salinity is a major threat to crop productivity, sustainable agriculture, and global food security, with more than 833 million hectares of land affected worldwide. Salt stress restricts plant growth through osmotic stress, ion toxicity, oxidative damage, …
pubmed
Usman M, Wang L, Xiaojuan A, Sun Z 等
2026 Aug 30
置信度 0.82
-
Ribosomal ITS2 is widely used in phylogenetic studies, yet its multigene organization and potential paralogy can obscure true species relationships. This proof-of-concept study investigates whether ITS2 sequences derived from long-read genomic data in multiple…
pubmed
Du K, Schartl M, Preising GA, Lu Y 等
2026 Aug 30
置信度 0.82
-
Pregnancy provides a unique physiological stress test for the cardiovascular system, during which, adverse pregnancy outcomes (APOs) can unmask latent susceptibility to future disease. Common complications, including hypertensive disorders of pregnancy (HDP), …
pubmed
Pabón MA, Smith G, Sharma G, Catov J 等
2026 Aug 30
置信度 0.82
-
The current study focuses on the synthesis and evaluation of novel Hydroxybenzothiazole-Linked Benzothiazole/Benzoxazole Conjugates to target Diabetes Mellitus (DM) by inhibiting α-amylase and α-glucosidase. Spectroscopic methods, including 1 H and…
pubmed
Hussain R, Sarfraz H, Khurshid U, Alqurashi N 等
2026 Aug 26
置信度 0.82
-
Lesion-symptom mapping is widely used to identify causal relationships between brain structures and behaviour, and has played a central role in neuropsychologically informed network models of cognition. However, even recent approaches remain constrained by a o…
pubmed
Nave R, Ng S, Moritz-Gasser S, Berger L 等
2026 Aug 26
置信度 0.82
-
Previous genome-wide association studies have identified more than 400 prostate cancer (PCa) susceptibility loci. However, the tissue and spatial epithelial contexts through which inherited PCa risk may operate in the normal prostate remain incompletely unders…
pubmed
Liu S, Chan OTM, Zhong H, Shahabi A 等
2026 Aug 30
置信度 0.82
-
Microbial carbon use efficiency (CUE) governs soil carbon persistence under warming, with its magnitude highly dependent on how microbial metabolism adapts to varying substrates. How agricultural management mediates this response in agroecosystems remains poor…
pubmed
Ling J, Wanek W, Mason-Jones K, Dungait JAJ 等
2026 Aug 30
置信度 0.82
-
Risperidone-clozapine response varies substantially in schizophrenia. HTR2A polymorphisms may influence antipsychotic response, but rs6311-rs6313 haplotypes remain unexplored in the Indonesian Batak population. This study evaluated associations of HTR2A rs6311…
pubmed
Hidayah N, Ikawati M, Amin MM, Ikawati Z
2026 Aug 20
置信度 0.82
-
Pre-emptive genotyping and genotype-guided dose adjustments are generally recommended for seven hypofunctional polymorphisms in the DPYD gene that are associated with fluoropyrimidine toxicity. However, targeted genotyping may miss uncommon and population-spec…
pubmed
Carp MJ, Ring G, Waldhorn I, Shempliner A 等
2026 Aug 4
置信度 0.82
-
Dapsone is a drug used to treat leprosy. Dapsone causes a highly morbid and potentially fatal severe drug hypersensitivity reaction (DHS) in 1-3% of leprosy cases. The allele HLA-B*13:01 is a known genetic risk factor for DHS. However, resource-intensive genot…
pubmed
Rana DR, Koju K, Shakya J, Manandhar S 等
2026 Aug 30
置信度 0.82
-
Vutrisiran, an RNA interference therapeutic that suppresses hepatic transthyretin production, improved survival and cardiovascular outcomes in transthyretin amyloidosis with cardiomyopathy (ATTR-CM) in HELIOS-B (A Study to Evaluate Vutrisiran in Patients With …
pubmed
Hamatani Y, Claggett BL, Cuddy SAM, Sarswat N 等
2026 Aug 30
置信度 0.82
-
Vutrisiran, an RNA interference therapeutic, reduced all-cause mortality and recurrent cardiovascular events in patients with transthyretin amyloid cardiomyopathy (ATTR-CM) in the HELIOS-B trial. Whether concomitant disease-modifying or heart failure therapy m…
pubmed
Abovich A, Fontana M, Claggett B, Gillmore JD 等
2026 Aug 5
置信度 0.82
-
SIRT1, a sirtuin family member, has been extensively documented to be closely linked to aging and aging-related disease. Cellular senescence is a state of irreversible cell cycle arrest that functions as a key driver of aging. During cellular senescence, LINE-…
pubmed
Wang X, Li T, Tang H, Liu MX 等
2026 Sep
置信度 0.82
-
Very rare and ultra-rare primary inherited arrhythmia syndromes (IAS) represent a heterogeneous group of disorders associated with a significant risk of sudden cardiac death, often manifesting from foetal life to early adulthood. Current guidelines primarily a…
pubmed
Sarquella-Brugada G, Mazzanti A, Baban A, Campuzano O 等
2026 Aug 4
置信度 0.82
-
The reduced diversity of the lung microbiome in respiratory conditions, including bronchiectasis, promotes bacterial infection and inflammation, contributing to worsening clinical outcomes. Traditional treatments often fail to address both infection and inflam…
pubmed
Glieca S, Tambassi M, Schianchi C, Quarta E 等
2026 Aug 30
置信度 0.82
-
Tofacitinib is an oral Janus kinase inhibitor used for the treatment of ulcerative colitis. This study evaluated efficacy/safety of dose reduction to tofacitinib 5 mg twice daily (BID) versus remaining on 10 mg BID in patients in stable remission on 10 mg BID.
pubmed
Rubin DT, Panés J, Torres J, Kobayashi T 等
2026 Jul
置信度 0.82
-
Background Recruiting families for neonatal clinical trials is challenging due to narrow enrollment windows, high clinical acuity, and parental stress, which contributes to concerns regarding representativeness in neonatology research. The Better Research Inte…
pubmed
Bartlett MJ, Kraft SA, Gray MM, Duenas D 等
2026 Jul
置信度 0.82
-
The infraorder Tabanomorpha represents a key lineage within the lower Brachycera; however, the phylogenetic placement of several families, including Pelecorhynchidae, remains incompletely resolved owing to the lack of mitogenomic data. In this study, we sequen…
pubmed
González CR, Saldarriaga-Córdoba M
2026
置信度 0.82
-
Facial aging reflects genetic, metabolic, and environmental influences. Although obesity has been associated with older perceived facial age, the shared genetic basis and direction of the BMI-facial aging relationship remain uncertain.
pubmed
Hu Y, Li KH, He MJ, Yu CS 等
2026
置信度 0.82
-
A significant proportion of type 2 diabetes cases remain undiagnosed despite screening advances, carrying substantial cardiometabolic risk. Artificial intelligence-enhanced electrocardiography (AI-ECG) detects subtle ECG changes in subclinical disease, potenti…
pubmed
Pastika L, Patlatzoglou K, Sieliwonczyk E, Barker J 等
2026 Aug
置信度 0.82
-
Peritoneal metastasis from lung adenocarcinoma is rare and generally associated with poor prognosis. Here, we report two cases of advanced NSCLC with multiple metastases in which the patients developed rare peritoneal metastases during disease progression. Nex…
pubmed
Zhang H, Han J, Rong F
2026
置信度 0.82
-
Urbanisation reshapes habitat structure, resource availability, and movement pathways for many wildlife species, often creating novel selective pressures and management challenges. The Australian white ibis ( Threskiornis molucca ) has rapidly expanded from it…
pubmed
Potvin DA, Webb AG, Fonseca TW, Gorring J 等
2026 Sep
置信度 0.82
-
Type 1 diabetes mellitus (T1DM) is a chronic disease that significantly impacts patients' quality of life. Its prevalence is rising globally each year. This study aims to identify potential biomarkers associated with T1DM through comprehensive bioinformatics a…
pubmed
Li J, Zhang S, Wang X, Yan D 等
2026
置信度 0.82
-
Chikungunya virus (CHIKV) is an emerging mosquito-borne alphavirus that has become a significant global public health concern due to its rapid spread and the debilitating acute and chronic joint pain (arthralgia) it causes. Understanding the molecular events t…
pubmed
Patil RR, Pawar S, Patil S, Hinge DD
2026 Jul
置信度 0.82
-
Multidrug-resistant (MDR) Gram-negative infections represent a growing global health threat with increasingly limited therapeutic options. We report a case of complicated urinary tract infection in a 70-year-old woman with underlying renal cysts complicated by…
pubmed
Boehm C, Dingle TC, Croxen MA, Lynch T 等
2026
置信度 0.82
-
Distinct ecological pressures shape accumulation of antimicrobial resistance genes (ARGs) and virulence genes in the gut microbiome. In this study, we used proximity ligation shotgun metagenomics to characterize bacterial host-mobilome relationships associated…
pubmed
Sommer AJ, Auch B, Khoruts A, Bajaj JS
2026 Sep 18
置信度 0.82
-
Diatoms are vital primary producers in marine ecosystems and play a key role in blue carbon sequestration. Although their circadian rhythms have been studied in isolation, how these rhythms are modulated by co-occurring bacteria remains unknown. Using a define…
pubmed
Chen J, Diao H, Su Y, Yuan Y 等
2026 Sep 18
置信度 0.82
-
The Notch signalling pathway regulates cell fate, proliferation, and differentiation and consists of receptors (Notch1-4), ligands (JAG1-2, DLL1, DLL3-4), and downstream targets. Altered expression of Notch pathway-linked genes has been reported in multiple ca…
pubmed
O'Hea H, Bourbonne V, Marignol L
2026 Nov
置信度 0.82
-
Circular RNAs (circRNAs) are covalently closed non-coding RNAs characterized by high stability, tissue-specific expression, and important regulatory roles in gene expression and cellular pathways across cancer, neurodegenerative, cardiovascular, autoimmune, an…
pubmed
Glovi A, Kalligosfyri PM, Miglione A, Iula G 等
2026 Sep 18
置信度 0.82
-
Animals frequently display aggressive behavior, for example, when competing for food. Aggression is influenced by various extrinsic and intrinsic factors such as the microbiome and genetics. However, we currently lack understanding what factors cause animals t…
pubmed
Krapf P, Cicconardi F, Schilling M, Aigner GP 等
2026 Sep 18
置信度 0.82
-
The actin cytoskeleton is a fundamental and highly conserved structure that functions in diverse cellular processes, yet its direct contribution to organismal aging remains unclear. Here, we systematically interrogated how genetic and pharmacologic perturbatio…
pubmed
Averbukh M, Nelson HT, Wang T, Lange CM 等
2026 Sep 18
置信度 0.82
-
Ischemic stroke induces rapid changes in transcriptional regulatory mechanisms across diverse genomic regions of the brain. These alterations fine-tune gene expression patterns to orchestrate post-stroke pathological responses. Precise control of these process…
pubmed
Arruri V, Mehta SL, Vemuganti R
2026 Sep 8
置信度 0.82
-
Patients receiving hemodialysis (HD) are at increased risk of severe coronavirus disease 2019 (COVID-19) and were prioritized for vaccination, yet vaccine hesitancy remains common. We assessed COVID-19 vaccine knowledge, acceptance, and attitudes among patient…
pubmed
Elsayed E, Kotb KM, Heiba A, Elhussini MS 等
2026 Sep
置信度 0.82
-
An integrated prognostic risk-score (RS) based on prognostic clinical factors and plasma copy number alterations (CNAs) across independent metastatic castration-resistant prostate cancer (mCRPC) cohorts was applied as a classifier to guide development of bioma…
pubmed
Kohli M, Wang L, Tan AC, Fadlullah MZ 等
2026 Sep
置信度 0.82
-
Over centuries, dogs have accompanied human populations during seasonal livestock movements associated with transhumance, contributing to the development of specialized pastoral dog populations. This study focuses on a population of heeling dogs distributed ac…
pubmed
Persichilli C, Ciampolini R, Riggio S, Di Civita M 等
2026 Sep
置信度 0.82
-
Methane emissions from beef cattle make a considerable contribution to global greenhouse gas (GHG) emissions, leading to environmental, economic, and production challenges. This review presents the current understanding on enteric methane emissions in cattle, …
pubmed
Taiwo E, Silva GM, Manafiazar G, Fitzsimmons C 等
2026 Sep
置信度 0.82
-
The cardiovascular-kidney-metabolic (CKM) syndrome framework integrates the shared pathophysiology of cardiovascular disease, excess adiposity, diabetes, and chronic kidney disease into a unified staging framework. Clonal haematopoiesis of indeterminate potent…
pubmed
Chang A, Li L, Ezzat D, Flynn S 等
2026 Aug 30
置信度 0.82
-
Hereditary ATTR amyloidosis with polyneuropathy (ATTRv-PN) frequently presents with gastrointestinal autonomic dysfunction, but its underlying pathology remains unclear.
pubmed
Hsueh HW, Yang PH, Tseng PH, Yeh TY 等
2026 Aug 29
置信度 0.82
-
pubmed
Shosha EAE, Eldaghayes I, Zanaty AM, Gamaleldin MA 等
2026 Aug 29
置信度 0.82
-
During host colonization, fungal plant pathogens secrete effector-like proteins that alter host cell physiology and target plant-associated microbes. However, rapid evolution and low sequence conservation hinder the study and characterization of these proteins…
pubmed
Dal'Sasso TCS, Stukenbrock EH
2026 Aug 29
置信度 0.82
-
GTSF1 is an essential activating cofactor for PIWI proteins in many metazoans. In the nematode Caenorhabditis elegans, however, GTSF-1 does not bind PIWI, but is associated with the RNA-dependent RNA polymerase RRF-3, supporting endo-siRNA (26G-RNA) biogenesis…
pubmed
Govind S, Ruppert S, Kirangwa J, Busetto V 等
2026 Aug 29
置信度 0.82
-
SlASIL2 can regulate tomato heat tolerance by suppressing the expression of SlHSP20/SlHSP90 and forming protein complexes with SlDREBA4. Tomato (Solanum lycopersicum) is an important vegetable crop with substantial economic value. High-temperature stress sever…
pubmed
Li X, Zhang H, Mo Y, Liu Y 等
2026 Aug 29
置信度 0.82
-
Genome sequencing enables accurate detection of genetic variants and is transforming rare disease diagnostics. While data generation is scalable, prioritization and clinical interpretation remain challenging, often requiring expert manual classification. AI-dr…
pubmed
Boceck D, Laugwitz L, Sturm M, Bezdan D 等
2026 Aug 29
置信度 0.82
-
The majority of breast cancer patients have tumors expressing estrogen receptor α (ER) and receive endocrine therapy. However, around one-third relapse in their disease, predominantly with retained ER expression. Molecular alterations are proposed to be …
pubmed
Schagerholm Stanev C, Robertson S, Toosi H, Sifakis EG 等
2026 Aug 30
置信度 0.82
-
Adeno-associated virus (AAV) mediated gene therapies has emerged as a potentially transformative treatment approaches for neuromuscular disorders, with two FDA-approved products now in widespread clinical use: onasemnogene abeparvovec (Zolgensma) for spinal mu…
pubmed
Orbach R, Gil Garzon MR, Büning H, Bönnemann C 等
2026 Jul 28
置信度 0.82
-
The dissemination of multidrug-resistant (MDR) Salmonella from agricultural environments into food systems constitutes a major safety hazard. This study combined genomic epidemiology and quantitative microbial risk assessment (QMRA) to investigate Salmonella t…
pubmed
Liao N, Huang P, Deng G, Liu D 等
2027 Jan
置信度 0.82
-
Fusarium graminearum causes cereal spoilage and mycotoxin production. Currently, biocontrol microorganisms have emerged as a safe and promising strategy to manage the contamination of toxin-producing fungi in cereal grains. The primary objective was to elucida…
pubmed
Zhang Y, Li J, Qiu Y, Zhao Y 等
2027 Jan
置信度 0.82
-
Koumiss exhibits various functional properties, including antioxidant, hypoglycemic, and antihypertensive effects; however, natural fermentation is characterized by an uncontrollable microbial community structure, significant fluctuations in product quality, a…
pubmed
Huang X, Luo R, Wang Y, Zheng W 等
2027 Jan
置信度 0.82
-
Since 2020, South Korea has seen a rapid surge in multidrug-resistant (MDR) Salmonella Infantis ST32 harboring pESI-like megaplasmids. We investigated the driving forces behind this emergence through a nationwide, four-year surveillance of major broiler slaugh…
pubmed
Kang HS, Ali MS, Moon BY, Kim MY 等
2027 Jan
置信度 0.82
-
Agmatine, the product of the decarboxylation of arginine, catalysed by arginine decarboxylase (ADC), is a bioactive compound that functions as a neuromodulator and co-transmitter and has gained increasing attention in recent years due to its therapeutic potent…
pubmed
Casado A, Wellner SM, Quirós A, Herrero-Fresno A 等
2027 Jan
置信度 0.82
-
Pseudomonas species are major psychrotrophic spoilage agents of dairy products, yet the molecular basis of spoilage variability among closely related strains remains poorly understood. This study integrates whole-genome sequencing, phenomics, and computational…
pubmed
Liang L, Wang P, Zhao X, Wang Z 等
2027 Jan
置信度 0.82
-
The spoilage bacterium Aeromonas veronii poses increasing risks to the safety of edible bivalves, yet the regulatory mechanisms of its key spoilage factors remain largely unknown. In this study, a foodborne pathogen A. veronii GL2 was isolated from edible Hyri…
pubmed
Tang X, He G, Wang D, Yu X 等
2027 Jan
置信度 0.82
-
Salmonella is widespread in foods, which could survive in sublethally injured state during processing and preservation with various techniques. To further elucidate the membrane damage effect and mechanism of sublethally injured cells, the sublethal injury eff…
pubmed
Man Y, Yang R, Liu Y, Xu W 等
2027 Jan
置信度 0.82
-
Salmonella is a major foodborne pathogen, with retail pork serving as a primary reservoir. This study investigated how fresh and chilled retail supply modes influence the genomic, antimicrobial resistance, and virulence profiles of Salmonella contaminating ret…
pubmed
Zheng J, Sun J, Shi B, Shi X 等
2027 Jan
置信度 0.82
-
Nontyphoidal Salmonella (NTS) is a leading zoonotic bacterial pathogen and a major cause of foodborne illness worldwide. Salmonella enterica subsp. enterica serovar Corvallis (S. Corvallis) has recently emerged in China as a serotype of concern, showing an ele…
pubmed
Yan S, Wu K, Zhang M, Tan D 等
2027 Jan
置信度 0.82
-
The Cryphonectriaceae (Diaporthales, Ascomycota) accommodates numerous important fungal pathogens that cause branch and stem canker diseases on woody plants worldwide. These include, for example, Cryphonectria (Cry.) parasitica, the causal agent of chestnut bl…
pubmed
Pham NQ, Wingfield BD, Marincowitz S, Marpaung YMAN 等
2026 Oct
置信度 0.82
-
Hypsizygus marmoreus (bunashimeji in Japanese) is a major cultivated edible mushroom in Japan. Characterizing its mating incompatibility factors in natural populations is essential for improving breeding efficiency. In this study, 71 wild isolates of H. marmor…
pubmed
Nakagoshi-Koike A, Nakano S, Kobayashi H, Ouchi K
2026 Oct
置信度 0.82
-
Aflatoxin contamination caused by Aspergillus flavus represents a serious food safety threat in tropical agroecosystems. This study examined the genetic diversity, population structure and geographical distribution of the mycotoxin biosynthetic gene clu…
pubmed
Sultana S, Rezve M, Bushra F, Yeasmin F 等
2026 Oct
置信度 0.82
-
Fungi differ from other eukaryotes in being hermaphroditic, lacking sexual dimorphism and relying on mating-type (MAT) loci for sexual compatibility. Previous studies indicate that mating types of Morchella sextelata exhibit sex-like characteristics, with MAT1…
pubmed
Ling J, Chen MQ, Ryberg M, Yang ZL 等
2026 Oct
置信度 0.82
-
Whole genome scans have identified numerous adaptive alleles in many species; however, linking these alleles to specific phenotypes remains a major challenge. A promising alternative to direct genotype-phenotype mapping, particularly given the complexities int…
pubmed
Kwakye A, Dzikowski N, Wund MA, Veeramah KR
2026 Aug 30
置信度 0.82
-
HBsAg is currently used as the key serum biomarker to define functional cure of chronic hepatitis B (CHB). Declining HBsAg is often interpreted as evidence of cccDNA elimination or durable transcriptional silencing. However, HBsAg can also be produced from tra…
pubmed
Suslov A, Matter MS, Calabrese D, El Taher A 等
2026 Aug 29
置信度 0.82
-
This study aims to elucidate the dynamic impact of different storage conditions (temperature and time) on the function of natural killer (NK) cells derived from umbilical cord blood (UCB) at the transcriptome level, providing a theoretical basis for optimizing…
pubmed
Xu J, Wang Y, Yang D, Zhang Z 等
2026 Aug 29
置信度 0.82
-
Metabolic dysfunction-associated steatohepatitis (MASH), a chronic liver disease, is characterized by persistent low-grade inflammation, partially driven by gut-derived lipopolysaccharide (LPS). Although repeated LPS exposure can induce endotoxin tolerance in …
pubmed
Lee H, Sim SJ, Han DM, Kim SY 等
2026 Aug 29
置信度 0.82
-
Research on virus nucleic acid-protein interactions is important to understand infection and guide antiviral drug design. In previous studies we showed that the human rhinovirus (RV) genomic RNA is organized as a dodecahedral cage formed by 30 RNA duplex eleme…
pubmed
Riomoros-Barahona V, Martínez-Romero JM, Valiente L, McGrail JP 等
2026 Aug 29
置信度 0.82
-
Methylotrophic yeasts are outstanding platforms for the production of recombinant proteins through precision fermentation. Growing demand for protein-based food ingredients requires economically viable secretion efficiency and space-time yields, as well as cor…
pubmed
Peng B, Tominaga M, Ishii J, Marcellin E 等
2026 Aug 29
置信度 0.82
-
pubmed
Helseth R, Badrouchi S, Cruz-Solbes AS, Marti-Castellote P 等
2026 Aug 29
置信度 0.82
-
The incubation period (I) for bird eggs varies among species and is used in establishing allometric relationships. Research on variations in I shed light on the evolutionary mechanisms that gave rise to the differentiation of embryonic development in distinct …
pubmed
Narushin VG, Romanov MN, Avni-Magen N, Griffin DK
2026 Aug 29
置信度 0.82
-
Although immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape of solid tumors, response rates in patients with small cell lung cancer (SCLC) remain limited, and acquired resistance is highly prevalent. The underlying mechanisms of th…
pubmed
Hou J, Zhu X, Guo J, Lu M 等
2026 Aug 29
置信度 0.82
-
Genetic testing for Lynch and BRCA1/2-associated hereditary cancer syndromes is recommended in colon or pancreatic cancer patients, but their association with hepatocellular carcinoma (HCC) risk is unknown. We evaluated associations between rare germline varia…
pubmed
Garofalo AM, Chotiprasidhi P, Johnson JP, Sato-Espinoza K 等
2026 Aug 29
置信度 0.82
-
Activated hepatic stellate cells (HSCs) play a central role in liver fibrosis by promoting extracellular matrix deposition, oxidative stress, and pro-fibrotic signaling. Here, we engineered a membrane-fused hybrid nanoparticle by combining grape-derived exosom…
pubmed
Han X, Lu R, Zhang Y, Bushra A 等
2026 Aug 29
置信度 0.82
-
Species largely evolve in isolation, with little exchange of genetic material between them. Occasionally, however, mechanism like horizontal transfer disrupt this isolation and transfers genetic information between species. Transposable elements (TEs), short D…
pubmed
Kofler R, Saadain S, Pinhasi R
2026 Aug 29
置信度 0.82
-
Desertification in the Brazilian semiarid has compromised ecosystem functionality, impacting soil microbial biodiversity. Thus, restoration strategies have been implemented, aiming to mitigate the negative impacts. However, little is known about their effects …
pubmed
Barbosa LMP, Silva DEO, Ventura SH, Costa MKL 等
2026 Aug 29
置信度 0.82
-
Listeria monocytogenes is a major foodborne pathogen; its ruminant isolates display zoonotic characteristics, causing similar clinical signs in humans, including abortion and encephalitis. However, data on whole genome sequencing and pathogenicity of ruminant …
pubmed
Kim J, Kim HY, Kim EM, Roh SG 等
2026 Aug 25
置信度 0.82
-
N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6PPDQ), an emerging tire-wear-derived environmental pollutant, has been associated with cardiac senescence, though its pathogenic mechanism remains unclear. Using in vitro (differentiated H9c2 cardiom…
pubmed
Fu B, Li J, Zhang M, Shang C 等
2026 Aug 26
置信度 0.82
-
Decreased removal and increased production of apolipoprotein B (apoB) containing lipoproteins cause hypercholesterolemia, a major causal risk factor of atherosclerotic cardiovascular disease. By a genome-wide siRNA screen, we previously identified subunits of …
pubmed
Panteloglou G, Robert J, Smit M, Huijkman N 等
2026 Aug 25
置信度 0.82
-
Broad molecular profiling via next-generation sequencing (NGS) is essential for guiding targeted therapy in advanced non-squamous non-small cell lung cancer (nsNSCLC). However, real-world implementation in low- and middle-income countries remains limited by op…
pubmed
Araújo BJ, Paes RD, Rodrigues AM, Kuhner PH 等
2026 Aug 29
置信度 0.82
-
High somatic cell count (SCC) is a critical indicator of udder health and milk quality in buffalo milk production. However, in many low-income regions, SCC monitoring is often underemphasized, allowing a proportion of high-SCC buffalo milk to enter the food ch…
pubmed
Wei Z, Xiang Y, Mo X, Li W 等
2026 Aug 26
置信度 0.82
-
Tuberculosis (TB) remains one of the leading causes of death from a single infectious agent worldwide, with timely diagnosis continuing to be a major challenge, particularly in resource-limited settings. Conventional TB diagnostic methods are limited by low se…
pubmed
Januarie KC, Uhuo OV, Sanga NA, Oranzie M 等
2026 Aug 28
置信度 0.82
-
Despite advances in percutaneous coronary intervention, ischemia-reperfusion (IR) injury remains a major cause of morbidity and mortality. Adiponectin confers broad cardioprotective effects, motivating the development of adiponectin receptor agonists. Here, we…
pubmed
Sung HK, Tang J, Lei Y, Nguyen K 等
2026 Sep
置信度 0.82
-
Long-read sequencing technologies have revolutionized human genome exploration at an unparalleled resolution, particularly facilitating the analysis of structural variation (SV) at haplotype resolution. Here, we present a protocol for using cuteHap, a robust f…
pubmed
Cao S, Wu C, He Y, Jiang T
2026 Aug 28
置信度 0.82
-
Biallelic variants in FSIP2 have been associated with multiple morphological abnormalities of the sperm flagella (MMAF) and acrosomal defects. This study aimed to characterize the genetic, sperm phenotypic, and reproductive features of infertile men carrying h…
pubmed
Chen J, Sun Y, Zhou T, Zhou J 等
2026 Aug 29
置信度 0.82
-
RNA N 6 -methyladenosine (m 6 A), as the most prevalent and abundant RNA modification on mRNAs, plays indispensable roles in biological processes and development by modulating the fate of target RNAs. However, whether other METTL proteins, besides dominant MET…
pubmed
Yang WL, Liu MX, Han Y, Li XX 等
2026 Aug 26
置信度 0.82
-
CRISPR technology is emerging as a promising therapeutic approach for eliminating chronic viral infections, such as herpesviruses and HIV. Here, for the first time, we demonstrate in vitro that CRISPR can be used to excise the HTLV-1 genome and reduce pro…
pubmed
Brancazio S, Khalili K, Jacobson S, Kaminski R
2026
置信度 0.82
-
Viral diseases are among the most serious threats to shrimp aquaculture, causing large-scale mortality and production losses. This review summarizes current knowledge on the major viral diseases affecting cultured penaeid shrimp and freshwater prawns, with par…
pubmed
Le LTT, Lao TD, Le PU, Tran HA 等
2026 Aug 29
置信度 0.82